CN108452156A - A kind of oral solution for treating coronary heart disease - Google Patents
A kind of oral solution for treating coronary heart disease Download PDFInfo
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/31—Extraction of the material involving untreated material, e.g. fruit juice or sap obtained from fresh plants
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Abstract
The invention discloses a kind of oral solutions for treating coronary heart disease, consist of the following compositions:60 80g of peony seed oil, 10 20g of linseed oil, 5 15g of walnut oil, Longstamen Onion Bulb 2 10g of oil, appropriate xylitol.The present invention provides the therapies of the oral solution simultaneously.Raw material of the present invention is simple and easy to get, according to the pathogenic factor and Clinical symptoms of coronary heart disease, carried out under instruction of Chinese Medicine theory prescription be raw material it is active on the basis of be prepared, show through clinical efficacy, the drug has coronary heart disease definite curative effect, it is a kind of ideal treatment medication of patients with coronary heart disease, the pharmaceutical formulation is scientific and reasonable, has curative effect high, it is quick, it the recurrence after healing can be avoided, at low cost, safety feature without side-effects.
Description
Technical field
The invention belongs to the field of Chinese medicines, and in particular to a kind of oral solution for treating coronary heart disease.
Background technology
Coronary heart disease is the abbreviation of coronary atherosclerotic heart disease, refers to the blood vessel-hat for supplying cardiotrophin substance
Serious atherosis or spasm occur for shape artery, make obliteration caused by coronary artery stenosis or blocking and thrombosis,
Lead to a kind of heart disease of myocardial ischemia-anoxemia or infraction, also known as ischemic heart disease.Coronary heart disease, which is atherosclerosis, to be caused
The most common type of organ lesion is to endanger the common disease of middle-aged and the old's health, and rejuvenation tendency is presented.CHD
(coronaryheartdisease, CHD) is common disease, the frequently-occurring disease for seriously endangering human health, leads to human death
One of three big diseases.Coronary heart disease is divided into 5 major class by the World Health Organization:Silent ischemia(Latent coronary heart disease), the heart twist
Bitterly, myocardial infarction, ischemic heart failure(Ischemic heart disease)With 5 kinds of Clinical types of sudden death.Usually it is divided into stabilization in clinic
Property coronary heart disease and acute coronary syndrome.21,300,000 will be increased from 2010 to the year two thousand thirty China's cardiovascular patient, the heart
Angiosis death toll will increase by 7,700,000.
Modern medicine is broadly divided into two classes under the guidance of this theory, to cardiopathic treatment means:First, using medicine
Object includes expansion blood vessel class drug and the molten lipid drug of thrombolysis;Second is that holder, bypass surgery.In the treatment of coronary heart disease, intervention
Operation and bypass surgery belong to invasive treatment, while postoperative complication seriously affects the health of patient.These methods
It is especially effective it is significant to rescue the sexual stage in the treatment to cardiac.But it cannot be from source
The upper precipitation again for solving the rubbish such as vascular lipids forms new patch, causes blood vessel restenosis, blocks, myocardial blood supply is not
The problem of smooth old disease recurrence.
At present for two methods of the treatment of the treatment key agents of coronary heart disease and operative treatment, but Western medicine side effect in doctor trained in Western medicine
Greatly, and it is palliative;And operative treatment risk is big, costly, the pain that patient bears is big.Coronary heart disease is in Chinese medicine category " chest
Numbness ", " pained " scope, can not only improve the symptom of patient using Coronary Heart Diseases Treated with TCM and can largely improve
The pathology damage of patient shows its unique advantage in coronary heart disease treatment.There are miscellaneous treatments on market today
The Chinese medicine of coronary heart disease, but their therapeutic effect is not generally high, and the course for the treatment of is longer, the defects of being easy to recur after healing.
Invention content
For problems of the prior art, the present invention provides a kind of drugs for treating coronary heart disease.The pharmaceutical formulation
It is scientific and reasonable, there is curative effect height, it is quick, it the recurrence after healing can be avoided, at low cost, safety feature without side-effects.
The present invention uses following technical scheme:
A kind of oral solution for treating coronary heart disease, consists of the following compositions:Peony seed oil 60-80g, linseed oil 10-20g, walnut
Oily 5-15g, Longstamen Onion Bulb oil 2-10g, appropriate xylitol.
Preferably, a kind of oral solution for treating coronary heart disease, consists of the following compositions:Peony seed oil 70g, linseed oil 15g,
Walnut oil 10g, Longstamen Onion Bulb oil 5g, appropriate xylitol.
The preparation method of the oral solution for the treatment of coronary heart disease described above, includes the following steps:
(1)Peony seeds are taken, are crushed, broken peony seeds particle is put into frying pan, the 180-210 DEG C of stir-fry of control temperature by control temperature
System 20 minutes, when being cooled to 140-150 DEG C, frying 5 minutes when frying, is sprayed water into peony seeds several times, point more when frying
It is secondary to spray water into peony seeds, when water content is 10% in detection material, stops frying and water spray, be down to room temperature;By good male of frying
Red seed particle is put into squeezer and is squeezed, and specific squeezing process is:After pressure reaches 20 MPA, control rate of pressure rise is 0.2-
0.3MPA/min, boosts to 25-28 MPA, and after pressurize 5-6min, pressure is gradually reduced, and when pressure is down to 20MPA, then is controlled
Rate of pressure rise is 0.2-0.3MPA/min, boosts to 25-28 MPA, pressurize 5-6min, repeats above-mentioned batch press process 3-4 times
Afterwards, it obtains filter cake and peony seed oil is spare;
(2)Linseed is taken, is crushed, in 50-60 DEG C of frying 30-40min, is warming up to 60-70 DEG C, after frying 5-10min, is boosted to
30-35 MPA are suppressed 2 hours, are obtained filter cake and linseed oil is spare;
(3)Walnut is taken, is crushed, in 50-60 DEG C of frying 30-40min, is warming up to 60-70 DEG C, after frying 5-10min, is boosted to
30-35 MPA are suppressed 2 hours, are obtained filter cake and walnut oil is spare;
(4)Longstamen Onion Bulb is taken, after crushing, in 40-50 DEG C of frying 30-40min, 60-70 DEG C is warming up to, after frying 5-10min, boosts to
25-28 MPA are suppressed 2 hours, are obtained filter cake and Longstamen Onion Bulb oil is spare;
(5)By step(1)-(4)Peony seed oil, linseed oil, walnut oil, the Longstamen Onion Bulb oil of middle gained are put into container and are sufficiently stirred
Mixing, blender revolution are 400r/min, and xylitol is then added, obtains admixing medical solutions;PH value is adjusted with sodium hydroxide solution
Into 6.8, then embedding to soda-lime glass tubular oral liquid bottle, the filling lid that rolls is placed on 98 DEG C of conditions, and sterilize 15min, and storage is
Be finished product to get treatment coronary heart disease oral solution.Every 5 grams of oral solution.
Application method is:Adult is each primary daily morning and evening, one every time.
Advantageous effect
Raw material of the present invention is simple and easy to get, and according to the pathogenic factor and Clinical symptoms of coronary heart disease, group is carried out under instruction of Chinese Medicine theory
Side be not raw material it is active on the basis of be prepared, show that the drug has exact treatment to coronary heart disease through clinical efficacy
Effect, is a kind of ideal treatment medication of patients with coronary heart disease.
Specific implementation mode
It elaborates below to the embodiment of the present invention, the present embodiment is carried out lower based on the technical solution of the present invention
Implement, gives detailed embodiment and specific operating process, but protection scope of the present invention is not limited to following implementation
Example.
Embodiment 1
A kind of oral solution for treating coronary heart disease, consists of the following compositions:Peony seed oil 70g, linseed oil 15g, walnut oil 10g,
Longstamen Onion Bulb oil 5g, appropriate xylitol.
The preparation method of the oral solution for the treatment of coronary heart disease described above, includes the following steps:
(1)Peony seeds are taken, are crushed, broken peony seeds particle is put into frying pan by control temperature, controls 190 DEG C of fryings 20 of temperature
Minute, when being cooled to 150 DEG C, frying 5 minutes when frying, is sprayed water into peony seeds several times, when frying, several times to tree peony
It sprays water in seed, when water content is 10% in detection material, stops frying and water spray, be down to room temperature;By the good peony seeds particle of frying
It is put into squeezer to be squeezed, specific squeezing process is:After pressure reaches 20 MPA, control rate of pressure rise is 0.3MPA/min,
Boost to 26 MPA, after pressurize 5min, pressure is gradually reduced, and when pressure is down to 20MPA, then is controlled rate of pressure rise and is
0.3MPA/min, boosts to 26 MPA, pressurize 5min, after repeating above-mentioned batch press process 4 times, obtains filter cake and peony seed oil is standby
With;
(2)Linseed is taken, is crushed, in 60 DEG C of frying 40min, is warming up to 70 DEG C, after frying 10min, 35 MPA is boosted to, suppresses
It 2 hours, obtains filter cake and linseed oil is spare;
(3)Walnut is taken, is crushed, in 50 DEG C of frying 30min, is warming up to 60 DEG C, after frying 5min, boosts to 30MPA, compacting 2 is small
When, it obtains filter cake and walnut oil is spare;
(4)Longstamen Onion Bulb is taken, after crushing, in 45 DEG C of frying 35min, 65 DEG C is warming up to, after frying 8min, boosts to 26MPA, compacting 2
Hour, it obtains filter cake and Longstamen Onion Bulb oil is spare;
(5)By step(1)-(4)Peony seed oil, linseed oil, walnut oil, the Longstamen Onion Bulb oil of middle gained are put into container and are sufficiently stirred
Mixing, blender revolution are 400r/min, and xylitol is then added, obtains admixing medical solutions;PH value is adjusted with sodium hydroxide solution
Into 6.8, then embedding to soda-lime glass tubular oral liquid bottle, the filling lid that rolls is placed on 98 DEG C of conditions, and sterilize 15min, and storage is
Be finished product to get treatment coronary heart disease oral solution.Every 5 grams of oral solution.
Embodiment 2
A kind of oral solution for treating coronary heart disease, consists of the following compositions:Peony seed oil 60g, linseed oil 10g, walnut oil 5g, Chinese onion
White oil 2g, appropriate xylitol.
The preparation method is the same as that of Example 1.
Embodiment 3
A kind of oral solution for treating coronary heart disease, consists of the following compositions:Peony seed oil 70g, linseed oil 20g, walnut oil 15g,
Longstamen Onion Bulb oil 10g, appropriate xylitol.
The preparation method is the same as that of Example 1.
Clinical application example
1. clinical data:It randomly selects outpatient service and accepts patients with coronary heart disease 600 for medical treatment, be divided into Liang Zuji treatment groups and control group, two
There was no significant difference for clinical data between group, and two groups of ages, gender, the course of disease, complication etc. are statistically analyzed, and difference is without significantly
Property meaning(P>0.05), it is comparable.
2. diagnostic criteria:According to angina pectoris, the clinical medical history of myocardial infarction or electrocardiogram, open in-heart operation under pulsating, fortune
Dynamic load electrocardiogram, Nuclear Cardiac Imaging and coronarography can be made a definite diagnosis.
3. therapy:Treatment group is taken orally using drug made from the embodiment of the present invention 1, two times a day, 1 every time, meal
It takes within 1 hour afterwards, 10 days are 1 course for the treatment of, and general 1 course for the treatment of can take effect, and the 3-4 course for the treatment of can cure, and patient with severe symptoms needs 5-6 treatment
Journey.Control group is treated using conventional western medicine, such as Isosorbide Nitrate, beta-blocker, aspirin, Verapamil, pungent cuts down him
The drug therapies such as spit of fland, continuous treatment observe curative effect after 60 days.
4. curative effect determinate standard:
It cures:Normal ECG, clinical symptoms all disappear, and follow-up 1 year or more is without recurrence;
It improves:Electrocardiogram is clearly better, and clinical symptoms are substantially reduced or disappear more than half;
In vain:Electrocardiogram is without significant change, and clinical symptoms are without improvement.
5. treatment results:It is shown in Table 1.
1 clinical treatment outcome of table
Group case load | It cures | It improves | In vain | Total effective rate % | |
Treatment group | 300 | 246 | 48 | 6 | 98 |
Control group | 300 | 200 | 24 | 76 | 74.7 |
As can be seen from the above results, drug of the invention has the curative effect more preferable than general Western medicine to the treatment of coronary heart disease,
Treatment total effective rate be up to 98%, be it is a kind for the treatment of coronary heart disease good medicine, bring glad tidings to vast middle-old aged coronary heart disease patient.
Model case
Case 1:Lee, man, 60 years old, uncomfortable in chest, profuse sweating, Nausea and vomiting and when and with after breastbone squeezing property pain, angina pectoris,
It is diagnosed as coronary heart disease.Using the drug 2 years of the embodiment of the present invention 1, clinical symptoms all disappear, and follow-up is not recurred for 2 years.
Case 2:Mr. Wang, man, 84 years old, repeatedly pectoralgia have a surplus within 5 years, through using the drug 1 year of the embodiment of the present invention 1, suffer from
Person's clinical symptoms all disappear, and follow-up is not recurred for 2 years.
Case 3:Mr. Li, male, 74 years old, for paroxysmal pectoralgia more than 5 years, clinical diagnosis was coronary heart disease.Implemented using the present invention
After 2 years, clinical symptoms all disappear the drug of example 1, and follow-up is not recurred for 2 years.
Case 4:Mr. Wang, man, 64 years old, suffers from coronary heart disease and has a surplus for 5 years, frequent uncomfortable in chest, shortness of breath, dizzy, nausea and with when
And angina pectoris sense, carry out here treatment, using the drug 2 years of the embodiment of the present invention 1, clinical symptoms disappear more than half, continue to strengthen and control
Patient fully recovers after treating 2 courses for the treatment of, and follow-up is not recurred for 2 years.
Case 5:Guo so-and-so, man, 63 years old, suffer from coronary heart disease and have a surplus for 7 years, angina pectoris, come here treatment, use the present invention implement
The drug of example 13 years, clinical symptoms disappear, and patient fully recovers after continuing to strengthen 2 courses for the treatment of of treatment, and follow-up is not recurred for 2 years.
Case 6:Huang, man, 66 years old, suffers from coronary heart disease and has a surplus for 7 years, clinical using the drug 2 years of the embodiment of the present invention 1
Symptom disappears most, and patient fully recovers after continuing to strengthen 2 courses for the treatment of of treatment, and follow-up is not recurred for 2 years.
Case 7:Week so-and-so, female 74 years old, suffers from coronary heart disease and has a surplus for 7 years, uses patient after the drug 2 years of the embodiment of the present invention 1
Recovery from illness, follow-up are not recurred for 2 years.
Case 8:Suddenly so-and-so, man 55 years old, suffers from coronary heart disease and has a surplus for 3 years, using 5 courses for the treatment of of drug of the embodiment of the present invention 1,
Patient fully recovers afterwards, and follow-up is not recurred for 2 years.
Claims (3)
1. a kind of oral solution for treating coronary heart disease, which is characterized in that consist of the following compositions:Peony seed oil 60-80g, linseed
Oily 10-20g, walnut oil 5-15g, Longstamen Onion Bulb oil 2-10g, appropriate xylitol.
2. a kind of oral solution for treating coronary heart disease according to claim 1, which is characterized in that consist of the following compositions:It is male
Red seed oil 70g, linseed oil 15g, walnut oil 10g, Longstamen Onion Bulb oil 5g, appropriate xylitol.
3. a kind of preparation method of one of claim 1-2 oral solutions, which is characterized in that include the following steps:
(1)Peony seeds are taken, are crushed, broken peony seeds particle is put into frying pan, the 180-210 DEG C of stir-fry of control temperature by control temperature
System 20 minutes, when being cooled to 140-150 DEG C, frying 5 minutes when frying, is sprayed water into peony seeds several times, point more when frying
It is secondary to spray water into peony seeds, when water content is 10% in detection material, stops frying and water spray, be down to room temperature;By good male of frying
Red seed particle is put into squeezer and is squeezed, and specific squeezing process is:After pressure reaches 20 MPA, control rate of pressure rise is 0.2-
0.3MPA/min, boosts to 25-28 MPA, and after pressurize 5-6min, pressure is gradually reduced, and when pressure is down to 20MPA, then is controlled
Rate of pressure rise is 0.2-0.3MPA/min, boosts to 25-28 MPA, pressurize 5-6min, repeats above-mentioned batch press process 3-4 times
Afterwards, it obtains filter cake and peony seed oil is spare;
(2)Linseed is taken, is crushed, in 50-60 DEG C of frying 30-40min, is warming up to 60-70 DEG C, after frying 5-10min, is boosted to
30-35 MPA are suppressed 2 hours, are obtained filter cake and linseed oil is spare;
(3)Walnut is taken, is crushed, in 50-60 DEG C of frying 30-40min, is warming up to 60-70 DEG C, after frying 5-10min, is boosted to
30-35 MPA are suppressed 2 hours, are obtained filter cake and walnut oil is spare;
(4)Longstamen Onion Bulb is taken, after crushing, in 40-50 DEG C of frying 30-40min, 60-70 DEG C is warming up to, after frying 5-10min, boosts to
25-28 MPA are suppressed 2 hours, are obtained filter cake and Longstamen Onion Bulb oil is spare;
(5)By step(1)-(4)Peony seed oil, linseed oil, walnut oil, the Longstamen Onion Bulb oil of middle gained are put into container and are sufficiently stirred
Mixing, blender revolution are 400r/min, and xylitol is then added, obtains admixing medical solutions;PH value is adjusted with sodium hydroxide solution
Into 6.8, then embedding to soda-lime glass tubular oral liquid bottle, the filling lid that rolls is placed on 98 DEG C of conditions, and sterilize 15min, and storage is
Be finished product to get treatment coronary heart disease oral solution.
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WO2013185184A3 (en) * | 2012-06-15 | 2014-02-13 | Commonwealth Scientific And Industrial Research Organisation | Production of long chain polyunsaturated fatty acids in plant cells |
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CN104606456A (en) * | 2015-02-15 | 2015-05-13 | 郭书安 | Health medicine for treating hypertension and hyperlipidemia |
CN104667203A (en) * | 2015-03-30 | 2015-06-03 | 蒋金丽 | Medicine for treating coronary heart disease |
CN105670778A (en) * | 2016-02-18 | 2016-06-15 | 临沂真源观光农业科技有限公司 | Method for extracting peony seed oil from peony seeds |
CN105918505A (en) * | 2016-06-21 | 2016-09-07 | 厦门农特康生物科技有限公司 | Blend oil rich in alpha-linolenic acid and capable of protecting cardiovascular system |
CN106509160A (en) * | 2016-10-14 | 2017-03-22 | 广西放心源生物科技有限公司 | Edible blend oil |
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Title |
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胡晓军等: "亚麻籽油降血脂作用的研究 ", 《粮食加工》 * |
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