CN109288969A - A kind of Chinese medicine composition and its preparation for treating artery sclerosis - Google Patents
A kind of Chinese medicine composition and its preparation for treating artery sclerosis Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/898—Orchidaceae (Orchid family)
- A61K36/8984—Dendrobium
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/254—Acanthopanax or Eleutherococcus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/488—Pueraria (kudzu)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/537—Salvia (sage)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/704—Polygonum, e.g. knotweed
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
Abstract
The present invention discloses a kind of Chinese medicine composition for treating artery sclerosis, is prepared by dendrobium candidum, Cortex Acanthopanacis Radicis, pueraria lobata, Radix Salviae Miltiorrhizae, Radix Glycyrrhizae, corn stigma, tuber fleeceflower stem；Chinese medicine composition of the invention is prepared by several kinds of Chinese medicinal materials, safety is mild, it is minimum to human body side effect, have the effects that moistening lung kidney-nourishing, Shengyang Zhixie, promoting blood circulation, invigorating qi for strengthening superficies, dissipating stasis and stanching bleeding, calming the liver and benefiting the lungs, tranquilizing the mind dredging collateral, effectively treats all types of artery sclerosis；Chinese medicine composition of the invention may also be fabricated which the several formulations such as capsule, granule, oral solution, takes, is easy to carry, and the sufferer for meeting the different patient's condition is taken and carried, wide application of the crowd；In addition, Traditional Chinese medicine composition formula of the invention is scientific and reasonable, Small side effects, preparation method is simple, and preparation cost is low, can mitigate body and the financial burden of patient significantly, has very big promotional value.
Description
Technical field
The present invention relates to field of medicaments, and in particular to a kind of Chinese medicine composition and its preparation for treating artery sclerosis.
Background technique
Artery sclerosis is a kind of non-inflammation lesion of artery, is that ductus arteriosus wall thickens, is hardened, follows the string narrow with lumen
The general name of small degeneration and proliferative lesion common are atherosclerosis, medial arteriosclerosis, tiny artery sclerosis.
Atherosclerosis is type common in artery sclerosis, is the Etiological of myocardial infarction and cerebral infarction.
Artery sclerosis is with age and the vascular diseases of appearance, rule are usually to occur in adolescence,
It aggravates to person in middle and old age's period, fall ill.It is directed to the treatment of artery sclerosis at present based on drug therapy, followed by operative treatment.Medicine
Mainly based on reducing cholesterolemia, reduce blood triglyceride, often having drug is Simvastatin 10-40mg, daily 1-2 for object treatment
It is secondary.Or fibrate ciprofibrate, one time a day, each 50-100mg reduces tissue cholesterol deposition, it is viscous to reduce blood platelet
Attached property increases fibrinolytic activity and lowers fibrinogen concentration, to play the role of inhibiting blood clotting.But adjust blood lipid
Drug needs to take for a long time more.Operative treatment is mainly to narrow or occluded blood vessel, especially coronary artery, aorta, the arteria renalis and
Artery of extremity execution is led to again, reconstruction or bypass graft, or through interventional therapies such as the postoperative placement brackets of chamber blood vessel reshaping.This disease mesh
Preceding modern medicine there is no miracle cure.This disease has the characteristics that big to human health damage, disease incidence is high, the course of disease is long, gives
Patient brings great pain, and existing drug can only mitigate the clinical manifestation of the pain removal patient of patient and cannot eradicate
This disease achievees the purpose that healing.
Be accordingly used in treatment artery sclerosis drug must safely, effectively, have no toxic side effect, and Chinese pharmacology is as China
Traditional medicine has many advantages, such as that effect is strong, quick, lasting medicine, and do not have dependence, drug resistance and toxic side effect, because
This selects a kind of Chinese materia medica preparation to be used to treat artery sclerosis, has highly important clinical meaning for treatment artery sclerosis.
Summary of the invention
It is an object of the invention to overcome defect of the existing technology, a kind of Chinese traditional medicine composition for treating artery sclerosis is provided
Object and its preparation.
To achieve the goals above, The technical solution adopted by the invention is as follows:
The Chinese medicine composition for the treatment of artery sclerosis of the invention, is prepared: dendrobium candidum by the raw material of following parts by weight
45-100 parts, 120-200 parts of Cortex Acanthopanacis Radicis, 100-250 parts of pueraria lobata, 50-150 parts of Radix Salviae Miltiorrhizae.
Preferably, the Chinese medicine composition for the treatment of artery sclerosis of the invention further includes the raw material of following parts by weight: Radix Glycyrrhizae 40-
70 parts, 38-75 parts of corn stigma, 25-45 parts of tuber fleeceflower stem.
Preferably, the Chinese medicine composition for the treatment of artery sclerosis of the invention further includes the raw material of following parts by weight: Radix Glycyrrhizae 50-
60 parts, 45-60 parts of corn stigma, 35-40 parts of tuber fleeceflower stem.
It is the crude drug source of the traditional chinese medicine composition of the invention below:
Dendrobium candidum is the stem of orchid dendrobium candidum DendrobiumofficinaleKimuraetMigo.It is sweet in flavor,
Cold nature.With promoting fluid production and nourishing stomach, the effect of nourishing Yin and clearing heat, moistening lung kidney-nourishing, improving eyesight strong waist, consumption of body fluid caused by febrile disease is controlled, dry polydipsia, after being ill
Abnormal heat, impairment of yin mesh are dark.
Cortex Acanthopanacis Radicis is the drying of Araliaceae acanthopanax gracilistylus AcanthopanaxgracilistylusW.W.Smith
Root skin.It is pungent, bitter, temperature.Wind-damp dispelling, nourishing liver and kidney, strengthening the bones and muscles.For rheumatic arthralgia, muscles and bones impotence, children's retardation of walking, asthenia, water
It is swollen, tinea pedis.
Pueraria lobata is legume pueraria lobata Puerarialobata (Willd.) Ohwi or sweet kudzu
PuerariathomsoniiBenth. dry root.It is sweet, pungent, it is cool.Expelling pathogenic factors from muscles and skin is brought down a fever, and is promoted the production of body fluid, promoting eruption, Shengyang Zhixie.For exogenous disease
Fever and headache, stiff nape and back, it is thirsty, it quenches one's thirst, measles without adequate eruption, hot dysentery, diarrhea；Hypertension neck pain.
Radix Salviae Miltiorrhizae is the dry root and rhizome of Lamiaceae plant Radix Salviae Miltiorrhizae SalviamiltiorrhizaBge..Hardship, it is slightly cold.Return
The heart, Liver Channel.It is inducing meastruation to relieve menalgia with promoting blood circulation, relieving restlessness and restlessness, the effect of cool blood to disappear carbuncle.For chest impediment and cardialgia, stomach duct and abdomen hypochondriac pain,
The accumulation of lump in the abdomen lump in the abdomen, hot numbness pain, dysphoria and insomnia, irregular menstruation, dysmenorrhea menostasis, sore swell and ache curative.
Radix Glycyrrhizae is glycyrrhizic legume GlycyrrhizauralensisFisch., swollen fruit Radix
Or the dry root of glycyrrhiza glabra GlycyrrhizaglabraL. GlycyrrhizainflataBat..Sweet and neutral.It invigorates the spleen and benefits qi, clearly
Thermal detoxification, expelling phlegm and arresting coughing, relieving spasm to stop pain, coordinating the drug actions of a prescription.For weakness of the spleen and the stomach, fatigue and weakness, shortness of breath and palpitation, coughing with a lot of sputum, gastral cavity
Abdomen, four limbs contraction, carbuncle sore tumefacting virus alleviate drug toxicity, strong.
Corn stigma is the style and fresh idea of grass family Zea plant Zea mays ZeamaysL..It is adopted when autumn harvesting corn
It receives, dries or dry.It is sweet, light, it puts down.Inducing diuresis to remove edema, calming the liver and benefiting the lungs.For acute and chronic ephritis, oedema, acute hepatitis, chronic hepatitis is high
Blood pressure, diabetes, chronic nasosinusitis, lithangiuria, Biliary Calculi, the diseases such as difficult urination, neonatal jaundice caused by dampness-heat.And habituation can be prevented
Miscarriage.
Tuber fleeceflower stem is the rattan or leaf bine stem of polygonum multiflorum thunb.Sweet slight bitter is put down.Can nourishing heart, calm the nerves, dredging collateral dispels
Wind.Control insomnia, internal lesion caused by overexertion, hidrosis, deficiency of blood bodily pain, ulcer, scrofula, wind sore scabies tinea.
It is a further object of the present invention to provide the preparation method of the active constituent of the traditional chinese medicine composition of the invention, this method is to adopt
It is mentioned with water or the extraction of the ethyl alcohol of 40-70% concentration expressed in percentage by volume is prepared.It is specific the preparation method is as follows:
Scheme one: taking whole medicinal materials, and extracting in water 2-3 times after mixing, each amount of water is equivalent to the 6- of medicinal material total weight
12 times, each extraction time is 1-3 hours, combined extract, filtering, and relative density is 1.10- when filtrate is concentrated 70-80 DEG C
1.20 clear cream is to get active constituent.
Scheme two: taking whole medicinal materials, is extracted 2-3 times after mixing with 40-70% alcohol reflux, and each ethanol consumption is medicinal material
4-10 times of total amount, extraction time are 1-4 hours, and combined extract, filtering, relative density is when filtrate is concentrated into 70-80 DEG C
1.05-1.20 clear cream to get active constituent.
Scheme three: taking whole medicinal materials, and extracting in water 2-3 times after mixing, each amount of water is equivalent to the 6- of medicinal material total weight
12 times, each extraction time is 1-3 hours, combined extract, filtering, and relative density is 1.10- when filtrate is concentrated into 70-80 DEG C
Ethyl alcohol is added in 1.20 clear cream, makes alcohol content 40-70%, stands 12-24 hours, filtering, when filtrate is concentrated into 70-80 DEG C
Relative density is the medicinal extract of 1.05-1.20 to get active constituent.
The Chinese medicine composition for the treatment of artery sclerosis of the present invention, can also match with pharmaceutically acceptable carrier
It closes, various preparations, such as tablet, capsule, oral solution, syrup, mixture, granule is made.
Pharmaceutically acceptable carrier of the invention includes but is not limited to following:
Diluent: starch, Icing Sugar, lactose, dextrin, microcrystalline cellulose, inorganic salts, glycitols etc..
Wetting agent and adhesive: purified water, ethyl alcohol, gelatin, polyethylene glycol, cellulose derivative etc..
Disintegrating agent: starch, sodium carboxymethyl starch, cellulose derivative, crospovidone etc..
Lubricant: magnesium stearate, superfine silica gel powder, talcum powder, polyethylene glycol etc..
Cosolvent: water, ethyl alcohol, glycerol, propylene glycol, liquid paraffin, vegetable oil etc..
Corrigent: sucrose, monosaccharide, aromatic etc..
Preservative: benzoic acid, sorbic acid, methyl esters, ethyl ester, propyl ester etc..
Method 1: tablet
It takes scheme one one of to three gained active constituent of scheme, tablet is added and often uses auxiliary material, routinely prepared by production method
Obtain Tablets.
Above-mentioned tablet often includes one of diluent, wetting agent, adhesive, disintegrating agent, lubricant or whole with auxiliary material.
Method 2: capsule
It takes scheme one one of to three gained active constituent of scheme, capsule is added and often uses auxiliary material, routinely producer legal system
It is standby to obtain capsule of the present invention.
Above-mentioned capsule often includes one of diluent, wetting agent, adhesive, disintegrating agent, lubricant or whole with auxiliary material.
Method 3: syrup
It takes scheme one one of to three gained active constituent of scheme, syrup is added and often uses auxiliary material, routinely producer legal system
It is standby to obtain syrup of the present invention.
Above-mentioned syrup often includes one of corrigent, preservative, cosolvent or whole with auxiliary material.
Method 4: mixture
It takes scheme one one of to three gained active constituent of scheme, mixture is added and often uses auxiliary material, routinely prepared by production method
Obtain mixture of the present invention.
Above-mentioned mixture often includes one of corrigent, preservative or whole with auxiliary material.
Method 5: oral solution
Take scheme one one of to three gained active constituent of scheme, dissolution after-purification, concentration are added oral solution and often use auxiliary material,
Routinely production method is prepared into oral solution of the present invention.
Above-mentioned oral solution often includes one of corrigent, preservative, cosolvent or whole with auxiliary material.
Method 6: granule
It takes scheme one one of to three gained active constituent of scheme, granule is added and often uses auxiliary material, routinely producer legal system
It is standby to obtain granule of the present invention.
Above-mentioned granule often includes one of diluent, wetting agent, adhesive, disintegrating agent, lubricant or whole with auxiliary material.
Pueraria lobata is sweet, pungent, cool, enters spleen, stomach meridian, brings down a fever with expelling pathogenic factors from muscles and skin, promoting eruption, promotes the production of body fluid to quench thirst, the function of Shengyang Zhixie.Radix Salviae Miltiorrhizae
Hardship, it is slightly cold, enter the heart, pericardium, Liver Channel, there is promoting blood circulation for regulating menstruation, stasis-dispelling and pain-killing, cool blood to disappear carbuncle, the function of relieving restlessness tranquilizing the mind.One side pueraria lobata
Acrid flavour, pungent, can dissipate can manage it, and have the function of diverging, the promoting flow of qi and blood circulation, can promote the operation of passages through which vital energy circulates.Another aspect pueraria lobata, which has, to be risen
The function that sun promotes the production of body fluid, rising Yang refer to liter gas for lifting the clear sun of taste, reinforce the ability of transporting and transforming function of the spleen and stomach trough, in favor of the life of qi-blood-body fluid
At with defeated cloth, nourish blood vessels, improve because of the not smooth state of blood caused by insufficiency of vital energy and blood.Though two medicines all can activating microcirculation and removing stasis medicinal, be directed to
Object different from, Radix Salviae Miltiorrhizae is primarily directed to the tangible hemostasis in vascular, and pueraria lobata is mainly reflected in dredging and trophema
Arteries and veins.Two medicines " mutually making " are to use, and pueraria lobata can help Radix Salviae Miltiorrhizae activating microcirculation and removing stasis medicinal, promote blood operation, guarantee that blood is unimpeded.Modern pharmacology credit
The ingredient of analysis discovery pueraria lobata has more than 20 kinds, and main pharmacodynamics ingredient is Pueraria Flavonid, Puerarin, daidzein etc..Pueraria lobata is always yellow
Ketone can relax vascular smooth muscle, inhibit the abnormality proliferation of diabetic vascular smooth muscle, cause huve cell proliferation to high sugar
Damage has protective effect, is clearly indicated with Pueraria Flavonid Pueraria lobota ketone capsule for freeing collateral vessels as main component and is made with activating microcirculation and removing stasis medicinal
With for treating ishemic stroke apoplex involving the channels and collaterals convalescence hemostasis numbness resistance train of thought card.Puerarin has expansion blood vessel, improves micro- follow
Ring, the pharmacological action for increasing blood flow and anticoagulation, thrombus dissolving.There is decompression with yufeng ningxin tablets, yufeng ningxin pian made of kudzu root extract, increase
Add brain and coronary blood flow, improve myocardial metabolism, resist myocardial ischemia, improves a variety of effects such as Peripheral Microcirculation, spasmolysis.Radix Salviae Miltiorrhizae
Main chemical compositions are that fat-soluble diterpene quinone and water-soluble phenolic acid compound, Radix Salviae Miltiorrhizae are mainly used in painstaking effort
Guard system has protection cardiac muscle, expansion blood vessel, antiatherosclerosis, antithrombotic, improves microcirculation, promote angiogenesis, is anti-
Tumour, anti-hepatic fibrosis adjust the effects of immune, antibacterial anti-inflammatory.Pueraria lobata and Radix Salviae Miltiorrhizae or its component compatibility can play significantly
It expands blood vessel, improve the effects of circulation.The result of study of one treatment acute cerebral infarction shows Puerarin and Radix Salviae Miltiorrhizae Combined Ration list
It is solely more significant using Radix Salviae Miltiorrhizae person plasma tissue type activator of plasminogen (t-PA), the horizontal rising of nitric oxide (NO), and group
Knit type Fibrinolytic activity (PAI), Endothelin (ET) level is remarkably decreased, prompt Puerarin can cooperate with Treated with Radix Salviae Miltiorrhizae and improve
The function of vascular endothelium of Patients with Cerebral Infarction, it is small that mechanism of action may expand cardiovascular and cerebrovascular, vasodilator smooth muscle, anti-blood with it
Plate aggtegation is related.Puerarin and danshen injections are for treating Patients with Cerebral Infarction neurological dysfunction, and as a result the two is combined
Medication can more individually advantageously promote the neurological functional recovery of Patients with Cerebral Infarction with any one drug.Dashing forward deaf morbidity may be with
Inner ear microcirculation obstacle causes inner ear hair cells functional lesion related, studies have shown that Puerarin and Radix Salviae Miltiorrhizae combination therapy dash forward it is deaf
Curative effect, which is substantially better than, individually uses Treated with Radix Salviae Miltiorrhizae.Pueraria lobata and Radix Salviae Miltiorrhizae combination can improve diabetic eye diseases rat model retina cell and wither
Contracting, the pathological changes such as blood vessel hyperplasia, expansion, hyperemia, better than pueraria lobata is used alone.It can be seen that pueraria lobata, Radix Salviae Miltiorrhizae and its group distribution
5 can produce synergistic effect in terms of improving, and confirm that pueraria lobata, Radix Salviae Miltiorrhizae " mutually make " the feasible of compatibility from modern medicine angle
Property.
The applicant combines Traditional Chinese Medicine Coryza Treated by Syndrome Differentiation and modern pharmacological research achievement to compare by many years development test
Multiple formulations obtain with moistening lung kidney-nourishing, Shengyang Zhixie, promoting blood circulation, invigorating qi for strengthening superficies, dissipating stasis and stanching bleeding, calming the liver and benefiting the lungs, calm the nerves and lead to
The Chinese medicine composition of the effects of network.Chinese medicine composition of the invention can dissipate blood and dissolving stasis, promoting blood circulation and stopping pain using Radix Salviae Miltiorrhizae as monarch drug in a prescription；Pueraria lobata
For ministerial drug, pueraria lobata rising Yang is promoted the production of body fluid, can principal drug assistance activating microcirculation and removing stasis medicinal；It, can bowl spares using dendrobium candidum, Cortex Acanthopanacis Radicis, tuber fleeceflower stem as adjutant
QI invigorating, strengthening spleen and tonifying lung, nourishing Yin and promoting production of body fluid, kidney calming, warming meridian, helps yang transforming qi, it is strong that adjutant carries out qi and blood, can help and help
Monarch drug in a prescription and ministerial drug promoting blood circulation to remove blood stasis promoting the circulation of qi, and can help and make its blood-activating and qi-promoting too qi and blood is lost；Radix Glycyrrhizae, corn stigma are to make medicine, are put down
Liver cholagogue, coordinating the drug actions of a prescription, full side play altogether promoting blood circulation to remove blood stasis, invigorating qi for strengthening superficies, eliminating blood stasis and smoothing collaterals, promoting qi circulation and relieving pain function, effective treatment artery
Hardening.
The present invention is by adopting the above-described technical solution, have the advantages that
(1) Chinese medicine composition of the invention and its preparation are prepared by several kinds of Chinese medicinal materials, and safety is mild, are made to human body pair
With minimum, there is moistening lung kidney-nourishing, Shengyang Zhixie, promoting blood circulation, invigorating qi for strengthening superficies, dissipating stasis and stanching bleeding, calming the liver and benefiting the lungs, tranquilizing the mind dredging collateral etc. to make
With Radix Salviae Miltiorrhizae energy activating microcirculation and removing stasis medicinal is removed obstruction in channels to relieve pain, blood-nourishing calming heart；Tuber fleeceflower stem mental-tranquilization, clearing and activating the channels and collaterals had not only been invigorated blood circulation but also blood-nourishing, dissolving stasis
Without hurting just；Dendrobine in dendrobium candidum can dendrobine have and increase blood glucose, reduce blood pressure, weaken cardiac contractile force, wilsonii
Pi Ze has antihypertensive effect, and energy expansion of cerebral vascular improves the amount of blood supply of brain；Pueraria lobata and Radix Salviae Miltiorrhizae compatibility can play apparent expansion blood
Pipe, the effect for improving circulation；Full side play altogether blood circulation promoting nourishes blood, eliminating blood stasis and smoothing collaterals, promoting qi circulation and relieving pain function, it is athero- can effectively to treat artery
A plurality of types of artery sclerosis illnesss such as hardening, medial arteriosclerosis and tiny artery sclerosis.
(2) Chinese medicine composition of the invention and its preparation clinical tests prove that, atherosclerotic is controlled
More rate is 20.24%, total effective rate 91.67%；Cure rate to medial arteriosclerosis patient is 15.58%, total effective rate
It is 90.91%；Cure rate to tiny arteriosclerotic is 18.88%, total effective rate 90.57%, it is seen that in the present invention
Drug composition and its preparation can effectively treat the multiple types such as atherosclerosis, medial arteriosclerosis and tiny artery sclerosis
The artery sclerosis illness of type.Show that the traditional chinese medicine composition of the invention and its preparation have significant curative effect to artery sclerosis by clinical observation,
And curative effect is rapid, generally can feel substantially reduced after a week after taking to dizzy, headache, arrhythmia cordis etc. symptom, patient
Or disappear, the Liver and kidney function and hemopoietic system of patient are had no abnormal changes and adverse reaction, the state of an illness does not occur after drug withdrawal
" rebound ", clinic are taken securely and reliably.
(3) several formulations are made in Chinese medicine composition of the invention, take, is easy to carry, meet the sufferer clothes of the different patient's condition
With and carry, wide application of the crowd.
(4) Chinese medicine composition of the invention and its pharmaceutical formulation are scientific and reasonable, and Small side effects, preparation method is simple, preparation
It is at low cost, body and the financial burden of patient can be mitigated significantly, there is very big promotional value.
Specific embodiment
To make the objectives, technical solutions, and advantages of the present invention more comprehensible, preferred embodiment is enumerated below, to this hair
Bright further description.However, it is necessary to illustrate, many details listed in specification are used for the purpose of making reader to this
The one or more aspects of invention have a thorough explanation, also may be implemented even without these specific details of the invention
These aspects.Unless otherwise indicated, the percentage of the amount of alcohol in the present invention is percentage by volume, and v/v indicates the volume of solution
Than.
1 tablet of embodiment
Weigh dendrobium candidum 45kg, Cortex Acanthopanacis Radicis 120kg, pueraria lobata 100kg, Radix Salviae Miltiorrhizae 50kg, Radix Glycyrrhizae 40kg, corn stigma
38kg, tuber fleeceflower stem 25kg；Whole medicinal materials are taken, extracting in water 2 times after mixing, each amount of water is equivalent to the 12 of medicinal material total weight
Again, 10 times, extraction time is respectively 3 hours, 2 hours, combined extract, filtering, relative density when filtrate is concentrated 70 DEG C twice
For 1.10 clear cream, additive of tablet dextrin, talcum powder, sodium carboxymethyl starch, cellulose derivative is added, routinely scheme is made
Tablet.
2 tablet of embodiment
Weigh dendrobium candidum 50kg, Cortex Acanthopanacis Radicis 128kg, pueraria lobata 115kg, Radix Salviae Miltiorrhizae 64kg, Radix Glycyrrhizae 43kg, corn stigma
40kg, tuber fleeceflower stem 27kg；Whole medicinal materials are taken, are extracted 3 times after mixing with 40% alcohol reflux, each ethanol consumption is medicinal material total amount
10 times, 8 times, 6 times, extraction time is respectively 4 hours, 2 hours, 1 hour three times, combined extract, and filtering, filtrate is concentrated into
It is derivative that additive of tablet Icing Sugar, starch, polyethylene glycol, talcum powder, cellulose is added in the clear cream that relative density is 1.05 at 70 DEG C
Object, routinely tablet is made in scheme.
3 capsule of embodiment
Weigh dendrobium candidum 55kg, Cortex Acanthopanacis Radicis 136kg, pueraria lobata 135kg, Radix Salviae Miltiorrhizae 72kg, Radix Glycyrrhizae 46kg, corn stigma
42kg, tuber fleeceflower stem 30kg；Whole medicinal materials are taken, extracting in water 2 times after mixing, each amount of water is equivalent to the 12 of medicinal material total weight
Again, 8 times, each extraction time is respectively 3 hours, 2 hours, combined extract, filtering, relative density when filtrate is concentrated into 70 DEG C
For 1.10 clear cream, ethyl alcohol is added, makes alcohol content 40%, stands 12 hours, filtering, relative density when filtrate is concentrated into 70 DEG C
For 1.05 medicinal extract, capsule supplementary product starch, ethyl alcohol, magnesium stearate is added, routinely capsule is made in scheme.
4 capsule of embodiment
Weigh dendrobium candidum 60kg, Cortex Acanthopanacis Radicis 150kg, pueraria lobata 150kg, Radix Salviae Miltiorrhizae 80kg, Radix Glycyrrhizae 50kg, corn stigma
45kg, tuber fleeceflower stem 35kg；Whole medicinal materials are taken, extracting in water 3 times after mixing, each amount of water is equivalent to the 10 of medicinal material total weight
Again, 8 times, 6 times, each extraction time are respectively 3 hours, 2 hours, 1 hour, combined extract, filtering, when filtrate is concentrated 74 DEG C
Relative density be 1.15 clear cream, in clear cream be added capsule auxiliary material sodium carboxymethyl starch, microcrystalline cellulose, superfine silica gel powder,
Polyethylene glycol, routinely capsule is made in scheme.
5 syrup of embodiment
Weigh dendrobium candidum 67kg, Cortex Acanthopanacis Radicis 167kg, pueraria lobata 167kg, Radix Salviae Miltiorrhizae 100kg, Radix Glycyrrhizae 56kg, corn stigma
52kg, tuber fleeceflower stem 37kg；Whole medicinal materials are taken, are extracted 3 times after mixing with 50% alcohol reflux, each ethanol consumption is medicinal material total amount
8 times, 6 times, 4 times, each extraction time is respectively 3 hours, 2 hours, 1 hour, combined extract, and filtering, filtrate is concentrated into
The clear cream that relative density is 1.10 at 77 DEG C is added syrup auxiliary material monosaccharide, sorbic acid and water in clear cream and stirs evenly, is made
Syrup.
6 syrup of embodiment
Dendrobium candidum 45kg, Cortex Acanthopanacis Radicis 120kg, pueraria lobata 100kg, Radix Salviae Miltiorrhizae 50kg are weighed, whole medicinal materials is taken, is used after mixing
48% alcohol reflux extracts 3 times, and each ethanol consumption is 9 times, 6 times, 5 times of medicinal material total amount, and each extraction time is respectively 3 small
When, 2 hours, 1 hour, combined extract, filtering, when filtrate is concentrated into 75 DEG C relative density be 1.12 clear cream, in clear cream
Syrup auxiliary material aromatic, benzoic acid and water is added to stir evenly, syrup is made.
7 mixture of embodiment
Weigh dendrobium candidum 80kg, Cortex Acanthopanacis Radicis 180kg, pueraria lobata 200kg, Radix Salviae Miltiorrhizae 95kg, Radix Glycyrrhizae 60kg, corn stigma
60kg, tuber fleeceflower stem 40kg；Whole medicinal materials are taken, extracting in water 3 times after mixing, each amount of water is equivalent to the 10 of medicinal material total weight
Again, 8 times, 6 times, each extraction time are respectively 3 hours, 2 hours, 1 hour, and combined extract filters, and filtrate is concentrated into 75 DEG C
When relative density be 1.15 clear cream, ethyl alcohol is added, makes alcohol content 55%, stands 18 hours, filters, filtrate is concentrated into 74 DEG C
When relative density be 1.10 medicinal extract, in medicinal extract be added mixture auxiliary material sucrose, benzoic acid, stir evenly, be made mixture.
8 mixture of embodiment
Dendrobium candidum 67kg, Cortex Acanthopanacis Radicis 167kg, pueraria lobata 167kg, Radix Salviae Miltiorrhizae 100kg are weighed, whole medicinal materials are taken, after mixing
Extracting in water 3 times, each amount of water is equivalent to 9 times of medicinal material total weight, 7 times, 6 times, and each extraction time is respectively 3 hours, 2
Hour, 1 hour, combined extract, filtering, the clear cream that relative density is 1.18 when filtrate is concentrated into 77 DEG C are added ethyl alcohol, make to contain
Alcohol amount is 60%, stands 20 hours, filtering, and the medicinal extract that relative density is 1.08 when filtrate is concentrated into 72 DEG C is added in medicinal extract
Mixture auxiliary material monosaccharide, methyl esters, stir evenly, and mixture is made.
9 oral solution of embodiment
Weigh dendrobium candidum 88kg, Cortex Acanthopanacis Radicis 186kg, pueraria lobata 214kg, Radix Salviae Miltiorrhizae 122kg, Radix Glycyrrhizae 63kg, corn stigma
65kg, tuber fleeceflower stem 42kg；Whole medicinal materials are taken, extracting in water 3 times after mixing, each amount of water is equivalent to the 10 of medicinal material total weight
Again, 7 times, 6 times, each extraction time are respectively 3 hours, 1 hour, 1 hour, combined extract, filtering, when filtrate is concentrated 80 DEG C
The clear cream that relative density is 1.20 is added oral solution auxiliary material sorbic acid, methyl esters and water in clear cream and stirs evenly, dispense, is made
Oral solution.
10 oral solution of embodiment
Dendrobium candidum 100kg, Cortex Acanthopanacis Radicis 200kg, pueraria lobata 250kg, Radix Salviae Miltiorrhizae 150kg are weighed, whole medicinal materials are taken, after mixing
Extracting in water 3 times, each amount of water is equivalent to 8 times of medicinal material total weight, 6 times, 6 times, and each extraction time is respectively 2 hours, 1
Mouth is added in hour, 1 hour, combined extract, filtering, the clear cream that relative density is 1.14 when filtrate is concentrated 78 DEG C in clear cream
It takes liquid auxiliary material ethyl ester, sucrose and water to stir evenly, dispense, oral solution is made.
11 granule of embodiment
Weigh dendrobium candidum 95kg, Cortex Acanthopanacis Radicis 192kg, pueraria lobata 236kg, Radix Salviae Miltiorrhizae 140kg, Radix Glycyrrhizae 66kg, corn stigma
70kg, tuber fleeceflower stem 43kg；Whole medicinal materials are taken, are extracted 2 times after mixing with 70% alcohol reflux, each ethanol consumption is medicinal material total amount
6 times, 4 times, extraction time is respectively 2 hours, 1 hour, combined extract, filtering, relative density when filtrate is concentrated into 80 DEG C
For 1.20 clear cream, auxiliary material lactose, gelatin, starch, microcrystalline cellulose are added in clear cream, pelletizes, dry, whole grain, obtained
Granula.
12 granule of embodiment
Weigh dendrobium candidum 100kg, Cortex Acanthopanacis Radicis 200kg, pueraria lobata 250kg, Radix Salviae Miltiorrhizae 150kg, Radix Glycyrrhizae 70kg, corn stigma
75kg, tuber fleeceflower stem 45kg；Whole medicinal materials are taken, extracting in water 2 times after mixing, each amount of water is equivalent to the 12 of medicinal material total weight
Again, 6 times, each extraction time is 3 hours, 2 hours, and combined extract, filtering, relative density is when filtrate is concentrated into 80 DEG C
Ethyl alcohol is added in 1.20 clear cream, makes alcohol content 70%, stands 24 hours, and filtering, relative density is when filtrate is concentrated into 80 DEG C
Auxiliary material dextrin, water, polyethylene glycol, crospovidone is added in 1.20 medicinal extract in medicinal extract, pelletizes, dry, whole grain, and obtained
Granula.
Clinical test is summarized
1 basic document
1.1 selections are diagnosed as patient 298 of artery sclerosis.Wherein the oldest person 72 years old, reckling 37 years old, average year
Age 52.3 years old；Course of disease 1-15；Atherosclerosis person 168, medial arteriosclerosis person 77, tiny arteriosclerosis 53
Example.Exclude gestation and breast feeding women, those who are allergic to this drug, severe cardiac pulmonary dysfunction, non-coronary disease characteristic of disease heart disease, kidney disease
Disease, hypertension, stomach patient.
2 diagnostic criteria
Referring to Chinese integrated Chinese and Western medicine peripheral angiopathy Professional Committee of committee publication " 2016 artery sclerosis are closed
Fill in disease diagnosis and criterion of therapeutical effect " (revised draft in 2016) diagnostic criteria.
3 treatment methods
It is given and is treated using the capsule of the embodiment of the present invention 4,3 times a day, each 5g, 30 days as one therapeutic course.
4 curative effect judging standards
Cure: symptom disappears, and checks after half a year of being discontinued without recurrence.
Effective: symptom disappears substantially.
Effective: symptom part is alleviated, and attack times, degree and duration has substantially reduced.
Invalid: symptom is without any improvement, and substantially with identical or attack times before treatment, degree and duration is
It aggravates.
5 results
By the treatment of three courses for the treatment of, clinical efficacy is shown in Table 1.
1 therapeutic effect of table
| Illness | Healing/example | Significantly/example | Effectively/example | In vain/example | Cure rate/% | Total effective rate/% |
| Atherosclerosis | 34 | 69 | 51 | 14 | 20.24 | 91.67 |
| Medial arteriosclerosis | 12 | 33 | 25 | 7 | 15.58 | 90.91 |
| Tiny artery sclerosis | 10 | 21 | 17 | 5 | 18.88 | 90.57 |
As it can be seen from table 1 the treatment by three courses for the treatment of, the cure rate to atherosclerotic are
20.24%, total effective rate 91.67%；Cure rate to medial arteriosclerosis patient is 15.58%, and total effective rate is
90.91%；Cure rate to tiny arteriosclerotic is 18.88%, total effective rate 90.57%, it is seen that Chinese medicine of the present invention
Composition and its preparation can effectively treat the multiple types such as atherosclerosis, medial arteriosclerosis and tiny artery sclerosis
Artery sclerosis illness.Show that the traditional chinese medicine composition of the invention and its preparation have significant curative effect to artery sclerosis by clinical observation, and
Curative effect is rapid, to dizzy, headache, arrhythmia cordis etc. symptom, patient can generally feel after a week after taking it is substantially reduced or
It disappears, the Liver and kidney function and hemopoietic system of patient is had no abnormal changes and adverse reaction, the state of an illness does not occur " anti-after drug withdrawal
Bullet ", clinic are taken securely and reliably.
Typical case
Case 1: XX, female, 47 years old.
Main suit: often feeling dizzy, failure of memory over nearly 5 years, successively occur twice over the past half year it is clouded in mind suddenly, two
Eye turns over, tic of limbs bites with tongue, and break out 3-5min or so every time, feels to have aches in the limbs after breaking-out, tired, appetite stimulator.
Previously without similar breaking-out.It checks: blood pressure 145-95mmHg.Eyeground understands depending on nipple boundary, arteria retina is thin, light reflection increases
By force, arteriovenous slightly intersects impression.Nervous system is without other positive signs.Head X-ray anterioposterior and lateral film is normal.Cholesterolemia
6.63mmol/L, triglycerides 2.88mmol/L, head ultrasonography middle line wave have no that displacement, brain CT examination be normal, electroencephalogram
Check that normal, rheoencephalogram inspection prompt blood vessel elasticity degree lowers, through being diagnosed as cerebral arteriovenous malformation.Take the embodiment of the present invention 1
Tablet more than 2 months, illness mitigates, and continues to take and consolidates within 2 months curative effect, does not recur after being discontinued 1 year.
Case 2: what X, male, 50 years old.
Main suit: breaking out property dizziness is more than 3 years, and when breaking-out feels to turn dark before one's eyes suddenly, itself feels to float and incline to fall sense,
Several seconds time can restore normal to several minutes, after prostrate.The breaking-out breaking-out when seat stands or sleeps long afterwards and gets up every time, hair
As when have nausea, no vomiting.Previously there is low blood pressure medical history.It is checked after being admitted to hospital: blood pressure 90/60mmHg.Nystagmus feminine gender, eyeground
Understand depending on nipple boundary.Arteria retina is thin, reflected light enhances, arteriovenous intersects slight impression.Other nothings of neurological examination
Positive sign.C spine ap & lat piece shows slight retrogression, and cholesterolemia 7.20mmol/L, brain CT examination is normal, electrocardiogram is examined
It looks into normal.Through being diagnosed as cerebral arteriovenous malformation.Take 5 syrup drug of the embodiment of the present invention 3 months, all diseases mitigate；It even served 2 again
The moon consolidates curative effect, restores normal, does not recur after half a year of being discontinued.
Case 3: old XX, male, 65 years old.
Main suit: having a surplus for headache and dizziness 7 years, with neck pain, tinnitus dim eyesight, dry be not intended to drink, small dreaminess of sleeping, pain in waist and lower extremities,
Upper and lower acroanesthesia, body sleepiness power, deep thready pulse, pink tongue tongue fur are few, blood pressure 180/110mmng, lipid examination: cholesterol
6.32mmol/L, triglycerides 2.15mmol/L, B lipoprotein 11.33g/L, doctor trained in Western medicine are diagnosed as hyperlipidemia, artery sclerosis, high blood
Pressure.It is bad to take troxerutin and other effects, turns to ask Chinese traditional treatment, it is dialectical are as follows: the deficiency of liver-yin and kidney-yin.Take the mouth of the embodiment of the present invention 9
Take liquid 2 months, all diseases mitigate；Continue symptom after taking 2 months to disappear substantially, veins string is slow, tongue fur is red, and blood lipid, blood pressure check equal
It is down to normally, follow-up is not recurred for many years.
Claims (8)
1. a kind of Chinese medicine composition for treating artery sclerosis, which is characterized in that be prepared by the raw material of following parts by weight: iron sheet
45-100 parts of dendrobium nobile, 120-200 parts of Cortex Acanthopanacis Radicis, 100-250 parts of pueraria lobata, 50-150 parts of Radix Salviae Miltiorrhizae.
2. the Chinese medicine composition for the treatment of artery sclerosis according to claim 1, which is characterized in that the Chinese medicine composition
It further include the raw material of following parts by weight: 40-70 parts of Radix Glycyrrhizae, 38-75 parts of corn stigma, 25-45 parts, 25-45 parts of tuber fleeceflower stem.
3. the Chinese medicine composition for the treatment of artery sclerosis according to claim 1, which is characterized in that the Chinese medicine composition
It further include the raw material of following parts by weight: 50-60 parts of Radix Glycyrrhizae, 45-60 parts of corn stigma, 35-40 parts of tuber fleeceflower stem.
4. the Chinese medicine composition for the treatment of artery sclerosis according to claim 1-3, it is characterised in that: its activity
Ingredient be using water mention or the ethyl alcohol of 40-70% concentration expressed in percentage by volume extraction be prepared.
5. the Chinese medicine composition for the treatment of artery sclerosis according to claim 4, which is characterized in that its active constituent is logical
It crosses what following methods were prepared: taking whole medicinal materials, extracting in water 2-3 times after mixing, each amount of water is equivalent to medicinal material gross weight
6-12 times of amount, each extraction time are 1-3 hours, combined extract, filtering, relative density when filtrate is concentrated into 70-80 DEG C
For 1.10-1.20 clear cream to get active constituent.
6. the Chinese medicine composition for the treatment of artery sclerosis according to claim 4, which is characterized in that its active constituent is logical
It crosses what following methods were prepared: taking whole medicinal materials, extracted 2-3 times after mixing with 40-70% alcohol reflux, each ethanol consumption
It is 4-10 times of medicinal material total amount, extraction time is 1-4 hours, and combined extract, filtering, filtrate is concentrated into opposite at 70-80 DEG C
Density is the clear cream of 1.05-1.20 to get active constituent.
7. the Chinese medicine composition for the treatment of artery sclerosis according to claim 4, which is characterized in that its active constituent is logical
It crosses what following methods were prepared: taking whole medicinal materials, extracting in water 2-3 times after mixing, each amount of water is equivalent to medicinal material gross weight
6-12 times of amount, each extraction time are 1-3 hours, combined extract, filtering, relative density when filtrate is concentrated into 70-80 DEG C
For the clear cream of 1.10-1.20, ethyl alcohol is added, makes alcohol content 40-70%, stands 12-24 hours, filtering, filtrate is concentrated into 70-
Relative density is the medicinal extract of 1.05-1.20 to get active constituent at 80 DEG C.
8. a kind of Chinese materia medica preparation for treating artery sclerosis, by the described in any item treatment arteries of any one of claim 1-3 or 5-7
The Chinese medicine composition of hardening is prepared with pharmaceutically acceptable carrier combination.
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|---|---|---|---|---|
| CN101085027A (en) * | 2006-06-08 | 2007-12-12 | 天津天士力制药股份有限公司 | Traditional Chinese medicinal composition containing red sage root and kudzuvine root and its preparation |
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2018
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101085027A (en) * | 2006-06-08 | 2007-12-12 | 天津天士力制药股份有限公司 | Traditional Chinese medicinal composition containing red sage root and kudzuvine root and its preparation |
Non-Patent Citations (1)
| Title |
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| 黄海英等: "丹葛滴丸成型的工艺研究", 《中医学报》 * |
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