CN101337006B - Compound liniment for treating acne - Google Patents
Compound liniment for treating acne Download PDFInfo
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- CN101337006B CN101337006B CN2008101401028A CN200810140102A CN101337006B CN 101337006 B CN101337006 B CN 101337006B CN 2008101401028 A CN2008101401028 A CN 2008101401028A CN 200810140102 A CN200810140102 A CN 200810140102A CN 101337006 B CN101337006 B CN 101337006B
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Abstract
The invention provides a composite liniment for curing acne and comedo, which comprises the following raw materials by weight ratio: 0.5 to 2.0 parts of tetracycline, 0.3 to 2.0 parts of erythrocin, 0.4 to 2.0 parts of cyproheptadine, 0.3 to 1.0 part of pennyroyal, 0.1 to 1 part of borneol, 1.0 to 2.5 parts of vitamin B6, 3 to 10 parts of radix notoginseng and 100 parts of plant extractive. The preparation method of the liniment comprises the following steps: weighing tetracycline, erythrocin, cyproheptadine, vitamin B6 and borneol; adding the plant extractive; stirring uniformly; adding pennyroyal; stirring uniformly; homogenizing for 10 to 30 minutes by the ultrasonic wave at the temperature of 0 DEG C to 10 DEG C; and split-charging to obtain the finished product. The liniment conformsto the chemical property of the skin, facilitates the performance of the physiological function of the skin, plays a role in not only curing but also protecting the skin, has multiple curative effects compared with the simple application of tetracycline and erythrocin, and reduces the dry and tension senses of the skin when in administration, furthermore, the liniment has low irritation and is easily accepted by the patients, thereby the application prospect is wide.
Description
Technical field
The present invention relates to a kind of medicine for the treatment of acne, a kind of specifically compound liniment for the treatment of acne.
Background technology
Acne is the common a kind of hair follicle of adolescence, sebaceous gland chronic inflammatory disease dermatoses.The traditional Chinese medical science is called " rosacea caused by lung-wind " or " acne vulgaris ", is commonly called as " strong pimple ".That its pathogeny be it is generally acknowledged is hyperfunction with sebum secretion, in the sebaceous gland conduit keratinization, conduit bacterial proliferation and abnormal inflammatory reaction relevant.Up to 95%, its skin lesion mainly betides face, chest, back portion and shoulder to acne at the adolescence sickness rate.Based on blackhead, pimple, abscess, also the skin lesion of different shapes such as nodosity, cyst, cicatrix occurs.Treatment does not still have specific medicament clinically at present.Mostly the clinical treatment method that is used for acne is to adopt skin surface to smear antiinflammatory, sterilization, antipruritic ointment, and its therapeutic effect is all not really desirable, is still the unsolved difficult problem of medical circle at present.
Summary of the invention
The purpose of this invention is to provide a kind of therapeutic effect good, be free from side effects, from toxin expelling, anti-inflammation and sterilization, reparation, reactivate Skin Cell, promote the epidermis microcirculation to make the skin exquisiteness, reach the compound liniment of the treatment acne for the treatment of both the principal and secondary aspects of a disease effect.
The compound liniment of treatment acne of the present invention is made up of following materials of weight proportions:
Tetracycline 0.5-2.0 part, erythromycin 0.3-2.0 part, Cyproheptadine 0.4-2.0,0.3-1.0 parts of Oleum menthae, 0.1-1 part of Borneolum Syntheticum, vitamin B
61.0-2.5 part, 3-10 parts in Radix Notoginseng, 100 parts of plant extraction liquids;
The preparation method of plant extraction liquid: get 20-40 parts of green tea, 10-25 parts of Semen Ginkgoes, 10-25 parts of Folium Ginkgos, adding distil water soaked 2 hours for 100-200 parts, wear into pasty state with fiberizer, be heated to and boil 10-20 minutes, filter and to be cooled to room temperature to make plant extraction liquid standby;
The preparation process of acne liniment is as follows: take by weighing tetracycline, erythromycin, Cyproheptadine, vitamin B by formula proportion
6, Borneolum Syntheticum adds in the plant extraction liquid and stirs, add Oleum menthae at last and stir, then under 0-10 ℃ of temperature with ultrasound wave homogenize 10-30 minutes, packing is finished product.
The invention has the beneficial effects as follows: help the performance of the physiological function of skin; Existing therapeutical effect has the effect of protection skin again, has multiple therapeutic effect than simple application tetracycline and erythromycin, reduced the drying of skin, nervous sense in the use, and zest is little, and the patient is easy to accept, and has a extensive future.Use tetracycline can suppress the fat melting antibacterial in the prescription, and may participate in the metabolism of sebaceous gland directly, reduce the free fatty composition of skin surface, erythromycin has the collaborative effect that suppresses the propionibacterium acnes growth, thereby the source of disease bacterium of having removed inflammation, and erythromycin can promote leukocytic apoptosis simultaneously, influence its chemotaxis, influence the statement of some cytokine, the generating process of inflammation-inhibiting has dual antiinflammatory action.To the allergic phenomena of the skin soft tissue that causes because of acne, Cyproheptadine has cholinolytic and antihistamine effect.Vitamin B6 is soluble in water, can increase Mucocutaneous metabolism and suppress anaphylaxis, promotes the growth of cell.Green tea in the solvent has antiinflammation, the juice that extracts bright Semen Ginkgo and Semen Ginkgo has the toxin expelling of special effect, the double effects of evacuation of pus, sebum in can the dissolved dilution follicular orifice, be beneficial to the discharge of exfoliative cyte, reduce the chance of secondary infection, simultaneously skin is had the effect of preserving moisture, moistening and prolonging local drug effect.Borneolum Syntheticum and Oleum menthae have the effect of refreshing and detoxicating, skin protection, finally reduce the formation of acne and struvite pimple, pustule.
The specific embodiment
Embodiment 1
Prescription: 0.5 part of tetracycline, 0.3 part in erythromycin, 0.4 part of Cyproheptadine, 0.3 part of Oleum menthae, 0.1 part of Borneolum Syntheticum, vitamin B
61.0 part, 3 parts in Radix Notoginseng, 100 parts of plant extraction liquids;
The preparation method of plant extraction liquid: get 20 parts of green tea, 10 parts of Semen Ginkgoes, 10 parts of Folium Ginkgos, 100 parts of adding distil waters soaked 2 hours, wore into pasty state with fiberizer, were heated to and boiled 10 minutes, filtered to be cooled to room temperature to make plant extraction liquid standby;
The preparation process of acne liniment is as follows: take by weighing tetracycline, erythromycin, Cyproheptadine, vitamin B in proportion
6, Borneolum Syntheticum adds in the plant extraction liquid and stirs, add Oleum menthae at last and stir, then under 0-10 ℃ of temperature with ultrasound wave homogenize 10-30 minutes, packing is finished product.
Embodiment 2
Prescription: 2.0 parts of tetracyclines, 2.0 parts in erythromycin, Cyproheptadine 2.0,1.0 parts of Oleum menthae, 1 part of Borneolum Syntheticum, vitamin B
62.5 part, 10 parts in Radix Notoginseng, 100 parts of plant extraction liquids;
The preparation method of plant extraction liquid: get 40 parts of green tea, 25 parts of Semen Ginkgoes, 25 parts of Folium Ginkgos, 200 parts of adding distil waters soaked 2 hours, wore into pasty state with fiberizer, were heated to and boiled 20 minutes, filtered to be cooled to room temperature to make plant extraction liquid standby;
Embodiment 3
Prescription: 0.5 part of tetracycline, 1.8 parts in erythromycin, Cyproheptadine 1.6,0.8 part of Oleum menthae, 0.8 part of Borneolum Syntheticum, vitamin B
62.2 part, 7 parts in Radix Notoginseng, 100 parts of plant extraction liquids.
The preparation method of plant extraction liquid is identical with embodiment 1-2 with the preparation method of acne liniment.
Embodiment 4
Prescription: 1.5 parts of tetracyclines, 1.8 parts in erythromycin, Cyproheptadine 1.6,0.8 part of Oleum menthae, 0.8 part of Borneolum Syntheticum, vitamin B
62.2 part, 7 parts in Radix Notoginseng, 100 parts of plant extraction liquids.
The preparation method of plant extraction liquid is identical with embodiment 1-2 with the preparation method of acne liniment.
Embodiment 5
1.2 parts of tetracyclines, 1.5 parts in erythromycin, 1.2 parts of Cyproheptadines, 0.7 part of Oleum menthae, 0.5 part of Borneolum Syntheticum, vitamin B
61.8 100 parts of part, plant extraction liquids.
The preparation method of plant extraction liquid is identical with embodiment 1-2 with the preparation method of acne liniment.
Treatment acne observation of curative effect
Acne is the commonly encountered diseases of department of dermatologry, is more common in hebetic men and women, and good sending out in face influences attractive in appearance.We adopted self-control acne preparation for treating II level acne vulgaris 60 examples in 2004-20008, obtain good result, now were summarized as follows.
Typical clinical case inclusion criteria:
Inclusion criteria: have typical clinical manifestation, meet the diagnostic criteria of II level acne vulgaris
1, do not do any Drug therapy in January, there is not the other diseases of merging.
Rejecting standard: to this product allergy sufferers; Prolonged application corticosteroid hormone person; Symptomatic acne; Therapy discontinued and can not further consultation person.
MethodsThe cases enrolled 60 examples, MethodsThe cases enrolled are my outpatient of section.Wherein male 32 examples, women 28 examples, man: woman=1.14; The oldest 25 years old, minimum 12 years old, average 18.6 years old; The shortest 2 weeks of the course of disease, the longest 3 years.
Model case
Case 1: gold is worn, woman, 16 years old, Sishui County Miao Guan town Huang Jia people from village.Facial red pimple, pus kitchen are gone to a doctor February, a plurality of pimples of meeting portion of having a medical check-up, pus kitchen, Semen phaseoli radiati grain size, a little acne.Diagnosis acne vulgaris (II level) adopts acne liniment of the present invention external, every day 3 times.Erythra obviously reduces after 1 week, the most of disappearance of 2 weeks, and 3 weeks fully recovered.
Case 2: Ma Yong, man, 19 years old, yellow people from city in holy water valley, Sishui County township.Facial red pimple, pus kitchen are gone to a doctor January, a plurality of pimples of meeting portion of having a medical check-up, pus kitchen, Semen phaseoli radiati grain size, a little acne.Diagnosis acne vulgaris (II level) adopts acne liniment of the present invention external, every day 3 times.1 week back erythra reduces, and 2 weeks continued to reduce, 3 weeks most of the disappearance, 4 weeks only residual 2 acne.
Case 3: Feng Guanghong, man, 16 years old, area just outside a city gate, Sishui County town Bao Cunren.Facial red pimple, pus kitchen are gone to a doctor October, have a medical check-up meeting portion more than 40 Semen phaseoli radiati grain size pimple, pus kitchen, a little acne, foxtail millet grain size.
Diagnosis acne vulgaris (II level) adopts acne liniment of the present invention external, every day 3 times.Erythra obviously reduces after 1 week, 2 all most of disappearances, 3 all pimples, the whole disappearances of pus kitchen, residual grain of rice size acne.
Case 4 Lee like the people, woman 16 years old, Sishui County Miao Guan town Huang Jia people from village.Facial red pimple, pus kitchen are gone to a doctor February, a plurality of pimples of meeting portion of having a medical check-up, pus kitchen, Semen phaseoli radiati grain size, a little acne.Diagnosis acne vulgaris (II level) adopts acne liniment of the present invention external, every day 3 times.Erythra obviously reduces after 1 week, the most of disappearance of 2 weeks, and 3 weeks fully recovered.
Case 5, Cui Minhai, the woman, 17 years old, family's hall was congratulated in the star villages and small towns.Facial played acne, red pimple, pustule 6 months, intensive grain of rice size acne of the meeting portion that haves a medical check-up and foxtail millet grain large red pimple, pustule, forehead, cheeks are work.Diagnosis acne vulgaris (II level).Adopt acne liniment of the present invention external, every day 3 times, the back pustule disappearance of 1 week, pimple reduces; 3 all pimples all disappear, and are dispersed in a little acne.
Case 6: Zhang Yuejin, man, 16 years old, Huang Gou township Xing family room.Facial played acne, red pimple, pustule 12 months, the treatment of once repeatedly going to a doctor, poor effect.Have a medical check-up meeting portion intensive grain of rice size blackhead and foxtail millet grain large red pimple, pustule, forehead, cheeks are work.Diagnosis acne vulgaris (II level).Adopt acne liniment of the present invention external, every day 3 times, pustule obviously reduces after 1 week, and pimples reduce obviously after 2 weeks, and 3 all pustule pimples all disappear, and are dispersed in a little acne; 4 all erythra all disappear.
Case 7: Lee's wind, woman, 24 years old, area just outside a city gate fountain.A facial acne, red pimple 6 months, intensive grain of rice size acne of the meeting portion that haves a medical check-up and foxtail millet grain large red pimple, forehead, cheeks are work.Diagnosis acne vulgaris (II level).Adopt acne liniment of the present invention external, every day 3 times, the back pimple minimizing of 1 week; 3 all pimples all disappear, and acne subtract obviously few; 4 all acne all disappear.
Case 8: Zhang Lin, woman, golden Zhuan Geshan.A facial red pimple, pustule 6 months, have a medical check-up meeting portion intensive foxtail millet grain large red pimple, pustule are distributed symmetrically, and forehead, cheeks are work.Diagnosis acne vulgaris (II level).Adopt acne liniment of the present invention external, every day 3 times, the back pustule disappearance of 1 week, pimple reduces; 3 all pimples all disappear.
Case 9: Jiang Shanshan, woman, 15 years old, willow river bend garden.Facial played acne, red pimple, pustule 8 months, more grain of rice size acne of the meeting portion that haves a medical check-up and foxtail millet grain large red pimple, pustule, forehead, cheeks are work.Diagnosis acne vulgaris (II level).Adopt acne liniment of the present invention external, every day 3 times, the back pustule disappearance of 2 weeks, pimple reduces; 3 all pimples all disappear, and are dispersed in a little acne.
Case 10: Zhang Ping, woman, 14, nasal mucus Zhang Xiaoshan.A facial acne, red pimple 3 months, intensive grain of rice size acne of the meeting portion that haves a medical check-up and foxtail millet grain large red pimple, forehead, cheeks are work.Diagnosis acne vulgaris (II level).Adopt acne liniment of the present invention external, every day 3 times, the back pimple minimizing of 1 week; 3 all pimples all disappear, and are dispersed in a little acne.
Case 11: Chen Zhongyu, man, 15 years old, holy water valley river.Facial played acne, red pimple, pustule 5 months, intensive grain of rice size acne of the meeting portion that haves a medical check-up and foxtail millet grain large red pimple, pustule, forehead, two
Cheek is work.Diagnosis acne vulgaris (II level).Adopt acne liniment of the present invention external, every day 3 times.The back pustule disappearance of 1 week, pimple reduces; 2 all pimples all disappear, and are dispersed in a little acne.
Case 12: Li Na, man, 14 years old, middle volume Xiao Li.The facial acne, red pimple 1 year of rising are surplus, intensive grain of rice size acne of the meeting portion that haves a medical check-up and foxtail millet grain large red pimple, and forehead, cheeks are work.Diagnosis acne vulgaris (II level).Adopt acne liniment of the present invention external, every day 3 times, the back pimple minimizing of 1 week; 3 all pimples all disappear, 4 all residual a little acne.
Case 13: Wang Hongwei, man, 20 years old, spring woods Liuhe.Facial played acne, red pimple, pustule 4 months, intensive grain of rice size acne of the meeting portion that haves a medical check-up and foxtail millet grain large red pimple, pustule, forehead, cheeks are work.Diagnosis acne vulgaris (II level).Adopt acne liniment of the present invention external, every day 3 times, the back pustule disappearance of 1 week, pimple reduces by 2 all pimples and all disappears, and is dispersed in a little acne.
Case 14 Qiao Zhi send out, man, 16 years old, the Zhe Gouwei village.Facial played acne, red pimple, pustule 3 months, intensive grain of rice size acne of the meeting portion that haves a medical check-up and foxtail millet grain large red pimple, pustule, forehead, cheeks are work.Diagnosis acne vulgaris (II level).Adopt acne liniment of the present invention external, every day 3 times, the back pustule disappearance of 1 week, pimple reduces; 3 all pimples all disappear, 4 all residual a little acne.
Case 15: congratulate, the man, 17 years old, family's hall was congratulated in the star villages and small towns.Facial played acne, red pimple, pustule 6 months, intensive grain of rice size acne of the meeting portion that haves a medical check-up and foxtail millet grain large red pimple, pustule, forehead, cheeks are work.Diagnosis acne vulgaris (II level).Adopt acne liniment of the present invention external, every day 3 times, the back pustule disappearance of 1 week, pimple reduces; 3 all pimples all disappear, and are dispersed in a little acne.
Medication and observational technique: dip in cotton swab and to get the acne preparation for preparing, evenly be applied to the affected part, area is slightly larger than skin lesion, early, middle and late each once, one month course of treatment.Before treatment, 1 week of treatment back, 2 weeks, 3 all and 4 weeks carried out clinical score.The method of scoring be with clinical manifestation inflammation pimple, pus kitchen by not having-0, light by-1, in-2, weigh-3, adding up after the scoring both is clinical score; Score * 100% before treatment back clinical improvements rate=(score before the treatment-treatment back score)/treatment.
Efficacy determination: adopt 4 grade standards
Recovery from illness clinical improvements rate 〉=95%; Produce effects clinical improvements rate＜95%, 〉=60%;
Effective clinical improvements rate＜60%, 〉=20%; Invalid clinical improvements rate＜20%;
Recovery from illness adds produce effects and adds up to effective percentage.
Therapeutic outcome sees Table
Side effect is observed
This group skin erythema occurs after 5 examples (8.3%) patient medication is arranged, excitement, but unprocessed spontaneous remission, and all therapy discontinued not finished until the course of treatment.
Claims (3)
1. compound liniment for the treatment of acne is characterized in that this liniment is made up of following materials of weight proportions medicine:
Tetracycline 0.5-2.0 part, erythromycin 0.3-2.0 part, Cyproheptadine 0.4-2.0, Oleum menthae 0.3-1.0 part, Borneolum Syntheticum 0.1-1 part, vitamin B
61.0-2.5 100 parts of parts, Radix Notoginseng 3-10 part, plant extraction liquid;
The preparation method of plant extraction liquid: get green tea 20-40 part, Semen Ginkgo 10-25 part, Folium Ginkgo 10-25 part, adding distil water 100-200 part was soaked 2 hours, wear into pasty state with fiberizer, be heated to and boil 10-20 minute, filter and to be cooled to room temperature to make plant extraction liquid standby;
The preparation process of acne liniment is as follows: take by weighing tetracycline, erythromycin, Cyproheptadine, vitamin B in proportion
6, Borneolum Syntheticum adds in the plant extraction liquid and stirs, add Oleum menthae at last and stir, then under 0-10 ℃ of temperature with ultrasound wave homogenize 10-30 minute, packing is finished product.
2. compound liniment according to claim 1 is characterized in that being made up of following materials of weight proportions medicine: 100 parts of tetracycline 0.5-1.5 parts, erythromycin 0.8-1.8 part, Cyproheptadine 0.7-1.6, Oleum menthae 0.5-0.8 part, Borneolum Syntheticum 0.2-0.8 part, vitamin B6 1.5-2.2 part, Radix Notoginseng 5-7 part, plant extraction liquid.
3. compound liniment according to claim 1 is characterized in that being made up of following materials of weight proportions medicine: 1.2 parts of tetracyclines, 1.5 parts in erythromycin, 1.2 parts of Cyproheptadines, 0.7 part of Oleum menthae, 0.5 part of Borneolum Syntheticum, vitamin B
61.8 100 parts of part, plant extraction liquids.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2008101401028A CN101337006B (en) | 2008-08-11 | 2008-08-11 | Compound liniment for treating acne |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2008101401028A CN101337006B (en) | 2008-08-11 | 2008-08-11 | Compound liniment for treating acne |
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| Publication Number | Publication Date |
|---|---|
| CN101337006A CN101337006A (en) | 2009-01-07 |
| CN101337006B true CN101337006B (en) | 2011-09-07 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2008101401028A Expired - Fee Related CN101337006B (en) | 2008-08-11 | 2008-08-11 | Compound liniment for treating acne |
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Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111529617A (en) * | 2020-05-12 | 2020-08-14 | 张冬芬 | Traditional Chinese medicine formula for acne removing oil and preparation method thereof |
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2008
- 2008-08-11 CN CN2008101401028A patent/CN101337006B/en not_active Expired - Fee Related
Non-Patent Citations (2)
| Title |
|---|
| 李卫红.三七制剂导入治疗聚合性痤疮的临床研究.《中国美容医学》.2000,334-336. * |
| 胡献国.粉刺中医疗法.《上海中医药报》.2003,中医大观第008 版. * |
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