CN108392515A - A kind of tinea of feet and hands treatment liquid - Google Patents
A kind of tinea of feet and hands treatment liquid Download PDFInfo
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- CN108392515A CN108392515A CN201810577602.1A CN201810577602A CN108392515A CN 108392515 A CN108392515 A CN 108392515A CN 201810577602 A CN201810577602 A CN 201810577602A CN 108392515 A CN108392515 A CN 108392515A
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- tinea
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- 239000007788 liquid Substances 0.000 title claims abstract description 58
- 208000002474 Tinea Diseases 0.000 title claims abstract description 30
- 241000130764 Tinea Species 0.000 title claims abstract description 28
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims abstract description 40
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 claims abstract description 27
- 235000016257 Mentha pulegium Nutrition 0.000 claims abstract description 23
- 235000004357 Mentha x piperita Nutrition 0.000 claims abstract description 23
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims abstract description 23
- 235000001050 hortel pimenta Nutrition 0.000 claims abstract description 23
- 244000246386 Mentha pulegium Species 0.000 claims abstract description 22
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical group [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims abstract description 22
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 claims abstract description 13
- 229960004889 salicylic acid Drugs 0.000 claims abstract description 13
- 239000005711 Benzoic acid Substances 0.000 claims abstract description 11
- 235000010233 benzoic acid Nutrition 0.000 claims abstract description 11
- 238000000605 extraction Methods 0.000 claims description 35
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 16
- 239000000284 extract Substances 0.000 claims description 10
- 239000011780 sodium chloride Substances 0.000 claims description 10
- 238000004519 manufacturing process Methods 0.000 claims description 9
- 239000002904 solvent Substances 0.000 claims description 9
- 235000019441 ethanol Nutrition 0.000 claims description 8
- 241000196324 Embryophyta Species 0.000 claims description 7
- 244000025254 Cannabis sativa Species 0.000 claims description 4
- 235000012054 meals Nutrition 0.000 claims description 4
- 238000012216 screening Methods 0.000 claims description 3
- 241001479543 Mentha x piperita Species 0.000 claims 1
- 150000003462 sulfoxides Chemical class 0.000 claims 1
- 230000001954 sterilising effect Effects 0.000 abstract description 16
- 238000004659 sterilization and disinfection Methods 0.000 abstract description 12
- 230000000694 effects Effects 0.000 abstract description 8
- 230000001139 anti-pruritic effect Effects 0.000 abstract description 5
- 239000003908 antipruritic agent Substances 0.000 abstract description 5
- 230000000306 recurrent effect Effects 0.000 abstract description 5
- 230000008439 repair process Effects 0.000 abstract description 4
- 238000000034 method Methods 0.000 abstract description 2
- 210000002683 foot Anatomy 0.000 description 20
- 239000000243 solution Substances 0.000 description 17
- 229940079593 drug Drugs 0.000 description 11
- 239000003814 drug Substances 0.000 description 11
- 210000003491 skin Anatomy 0.000 description 11
- 239000007921 spray Substances 0.000 description 11
- 201000004647 tinea pedis Diseases 0.000 description 11
- 241000894006 Bacteria Species 0.000 description 8
- 238000012360 testing method Methods 0.000 description 8
- 241000233866 Fungi Species 0.000 description 6
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- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 6
- 238000002474 experimental method Methods 0.000 description 5
- 241000222122 Candida albicans Species 0.000 description 4
- 230000003110 anti-inflammatory effect Effects 0.000 description 4
- 229940095731 candida albicans Drugs 0.000 description 4
- 239000003795 chemical substances by application Substances 0.000 description 4
- 201000010099 disease Diseases 0.000 description 4
- 230000012010 growth Effects 0.000 description 4
- 239000003960 organic solvent Substances 0.000 description 4
- 210000001519 tissue Anatomy 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- 241000893976 Nannizzia gypsea Species 0.000 description 3
- 241000223229 Trichophyton rubrum Species 0.000 description 3
- 230000000844 anti-bacterial effect Effects 0.000 description 3
- 230000003628 erosive effect Effects 0.000 description 3
- 230000006870 function Effects 0.000 description 3
- 239000001963 growth medium Substances 0.000 description 3
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- 238000002156 mixing Methods 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 208000024891 symptom Diseases 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- 208000003322 Coinfection Diseases 0.000 description 2
- 208000010195 Onychomycosis Diseases 0.000 description 2
- 208000003251 Pruritus Diseases 0.000 description 2
- 201000004681 Psoriasis Diseases 0.000 description 2
- 206010067197 Tinea manuum Diseases 0.000 description 2
- 241000893966 Trichophyton verrucosum Species 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 208000035475 disorder Diseases 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 229940105902 mint extract Drugs 0.000 description 2
- 239000002674 ointment Substances 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- 210000004243 sweat Anatomy 0.000 description 2
- 238000002560 therapeutic procedure Methods 0.000 description 2
- 201000005882 tinea unguium Diseases 0.000 description 2
- 230000017423 tissue regeneration Effects 0.000 description 2
- 208000002874 Acne Vulgaris Diseases 0.000 description 1
- 241001480043 Arthrodermataceae Species 0.000 description 1
- 206010007882 Cellulitis Diseases 0.000 description 1
- -1 Compound Dexamethasone Acetate Chemical class 0.000 description 1
- 229920000832 Cutin Polymers 0.000 description 1
- 206010048768 Dermatosis Diseases 0.000 description 1
- 206010016322 Feeling abnormal Diseases 0.000 description 1
- 206010020649 Hyperkeratosis Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 208000001126 Keratosis Diseases 0.000 description 1
- 244000245214 Mentha canadensis Species 0.000 description 1
- 235000001878 Mentha haplocalyx Nutrition 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 239000006159 Sabouraud's agar Substances 0.000 description 1
- 240000000203 Salix gracilistyla Species 0.000 description 1
- 241000219784 Sophora Species 0.000 description 1
- 241000246044 Sophora flavescens Species 0.000 description 1
- 206010043866 Tinea capitis Diseases 0.000 description 1
- 201000010618 Tinea cruris Diseases 0.000 description 1
- 208000025865 Ulcer Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 206010000496 acne Diseases 0.000 description 1
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- 230000001580 bacterial effect Effects 0.000 description 1
- 238000003287 bathing Methods 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 description 1
- 239000004327 boric acid Substances 0.000 description 1
- 229940126678 chinese medicines Drugs 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000037304 dermatophytes Effects 0.000 description 1
- 229960003657 dexamethasone acetate Drugs 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 239000003684 drug solvent Substances 0.000 description 1
- 210000002615 epidermis Anatomy 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 230000036074 healthy skin Effects 0.000 description 1
- 238000007654 immersion Methods 0.000 description 1
- 230000008595 infiltration Effects 0.000 description 1
- 238000001764 infiltration Methods 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 238000011081 inoculation Methods 0.000 description 1
- 230000003780 keratinization Effects 0.000 description 1
- 150000002576 ketones Chemical class 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 230000003908 liver function Effects 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
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- 230000000116 mitigating effect Effects 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- 229960000988 nystatin Drugs 0.000 description 1
- VQOXZBDYSJBXMA-NQTDYLQESA-N nystatin A1 Chemical compound O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1/C=C/C=C/C=C/C=C/CC/C=C/C=C/[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 VQOXZBDYSJBXMA-NQTDYLQESA-N 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 230000003204 osmotic effect Effects 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 239000008188 pellet Substances 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 239000000419 plant extract Substances 0.000 description 1
- 239000002574 poison Substances 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 239000013641 positive control Substances 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 210000004761 scalp Anatomy 0.000 description 1
- 208000017520 skin disease Diseases 0.000 description 1
- 230000009182 swimming Effects 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 208000009189 tinea favosa Diseases 0.000 description 1
- 230000000451 tissue damage Effects 0.000 description 1
- 231100000827 tissue damage Toxicity 0.000 description 1
- 231100000027 toxicology Toxicity 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
- 238000001291 vacuum drying Methods 0.000 description 1
- 230000002747 voluntary effect Effects 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
- A61K31/10—Sulfides; Sulfoxides; Sulfones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/60—Salicylic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/14—Alkali metal chlorides; Alkaline earth metal chlorides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/489—Sophora, e.g. necklacepod or mamani
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/534—Mentha (mint)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
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Abstract
Liquid is treated by a kind of tinea of feet and hands for the treatment of that dimethyl sulfoxide (DMSO), Radix Sophorae Flavescentis extractive liquid, peppermint extracting solution, salicylic acid, benzoic acid, sodium chloride form the present invention provides a kind of.It is poor the present invention overcomes only carrying out superficial sterilization in the prior art and being repaired using rear epidermal tissue, hidroschesis and it is antipruritic slowly, and the shortcomings that damage normal body tissue and recurrent exerbation, also application method is optimized.Tinea of feet and hands treatment liquid provided by the invention, which uses, to be had the effects that relieve pain rapidly, is antipruritic, deep layer sterilization, promotees skin repair, and is used simple, convenient, fast.
Description
Technical field
The present invention relates to a kind of product for treating psoriasis more particularly to a kind of products for treating tinea pedis.
Background technology
Psoriasis is divided into favus of the scalp, the tinea manuum, tinea pedis, jock itch, onychomycosis, ringworm of the body etc. according to disease sites difference.Mainly by public
Articles for use and personal unhygienic custom and mutual phase transmission have with the health of the public places such as hotel, bathing pool, swimming pool, haircut
Close relationship.Wherein, the pathogen of tinea pedis mainly has acrothesium floccosum, red hair in skin silk fungi (dermatophyte)
Tinea bacterium and trichophyton gypseum, Candida albicans can also cause.
Tinea pedis clinic is broadly divided into：Sweat sore type.Water sore is played in foot especially vola, or assembles in groups or be fused into mycotic ulcer caused by venereal disease, sore
Wall is not thicker fragile, and later water sore absorbs and dry furfur, feels scratchy distending pain.Interphalangeal erosion type.It is this type of most common, between toe because
Sweat impregnates and erosion is whitened, and often feels and itches and scratch, exposes ruddy face after broken, normal secondary infection and cause angioleucitis, pellet
Poison or cellulitis.Scales of skin that peel off keratinization type.There is the thicker scales of skin that peel off in vola, or even the keratoderma in whole volas thickens, and heel can
There is deep breach, causes pain, or even influence labour and walking along the street.
Tinea pedis erosion sepage or secondary infection person, medically leading method to be used now has：3% boric acid solution or
0.1% needs Buddhist slave that solution cleaning or soak；Or with immersions such as Compound Flavescent Sophora and Salicylic Acid Powder, JIAOXIAN YICIJINGs；Or acetic acid ointment, Da Ke
Rather, the ointment such as Compound Dexamethasone Acetate are smeared；If tinea pedis severe patient merges onychomycosis, also to take the circumstances into consideration to coordinate to take some nystatin etc orally
Drug, these drugs all have a certain impact to liver function.
Those described above treatment has certain effect, but has the deficiency of some, is all superficial sterilization and epidermis
The case where tissue repair, there are recurrent exerbations.So there is prodigious room for promotion in therapy and effect.
Invention content
The present invention be directed to only carry out superficial sterilization in the prior art and repair poor, hidroschesis and antipruritic using rear epidermal tissue
Slowly, and the shortcomings that normal body tissue damage and recurrent exerbation can be caused develop it is a can with deep layer sterilize, quickly repair
The new tinea of feet and hands of skin histology treats liquid.
The mechanism of this product invention is " Liquid Penetrant is theoretical "；It is a kind of mixed liquor of drug and organic solvent.By this product
It is sprayed on foot disorders position, foot disorders organization softening, lesion wound convergence can be killed tinea bacterium.Various drugs in mixed liquor
Anti-inflammatory, sterilization and tissue repair are played the role of in rapid collaboration.The organic solvent of this product has extraordinary infiltration function same
Shi Benshen has anti-inflammation and sterilization function again, can penetrate into the deep tissues of affected skin.In this way, organic solvent is as carrier, by anti-inflammatory,
The drug of sterilization penetrates into deep skin tissue, plays the effect of deep layer sterilization.To achieve the purpose that cure tinea pedis.Dimethyl
Sulfoxide is a kind of good organic solvent, itself has the function of anti-inflammatory, sterilization, and is a kind of extraordinary bleeding agent.Kuh-seng
With peppermint extracting solution, there is good mitigation to pruitus, meanwhile, there is the effect of convergence is sterilized.Salicylic acid is in dept. of dermatology
It is usually used in treating various chronic dermatosis such as acne (whelk), tinea etc.；Salicylic acid can dispel cutin, sterilization, anti-inflammatory, because rather than
Often it is suitble to the aging disease dirt of the sick foot position of removal.Benzoic acid is shared with salicylic acid in adult skin nosomycosis, mycotic infection of superficial part
Such as ringworm of the body, the tinea manuum and tinea pedis.The osmotic pressure that sodium chloride is used to adjust mixed liquor is consistent with capillary of skin.
Purpose of the present invention is to what is be achieved through the following technical solutions：
A kind of tinea of feet and hands treatment liquid, including following component：Dimethyl sulfoxide (DMSO), Radix Sophorae Flavescentis extractive liquid, peppermint extracting solution, bigcatkin willow
Acid, benzoic acid, sodium chloride.
Further, the tinea of feet and hands treatment liquid includes following component by weight：30-60 parts of dimethyl sulfoxide (DMSO) is planted
40 parts of object extracting solution, 2-10 parts of salicylic acid, 5-20 parts of benzoic acid, 0.5-2 parts of sodium chloride.
The preparation method that tinea of feet and hands treats liquid is as follows：
Dimethyl sulfoxide (DMSO), Radix Sophorae Flavescentis extractive liquid, peppermint extracting solution, salicylic acid, benzoic acid, sodium chloride are mixed by a certain percentage
It is molten.
Further, the plant extraction liquid is that the mixing of Radix Sophorae Flavescentis extractive liquid or peppermint extracting solution or both arbitrary proportion carries
Take liquid.
Preferably, the plant extraction liquid is Radix Sophorae Flavescentis extractive liquid：Peppermint extracting solution mass ratio is 1:1 mixing extraction
Liquid.
Wherein, the manufacture craft of the mint extract is 1) by broken 80 mesh screens of the peppermint grass meal after vacuum drying
Screening is placed in the extraction kettle of supercritical extract；2) supercritical CO is used2As solvent, the ethyl alcohol of a concentration of 60%-80%
Do entrainer；3) it adjusts extraction kettle to control extracting pressure in 5-15MPa, temperature control is at 30-50 DEG C, CO2Flow control exists
10-20L/h, extraction time are controlled in 1-2h, obtain brown mint extract.
Wherein, the manufacture craft of the Radix Sophorae Flavescentis extractive liquid is：1) dry kuh-seng is crushed after being screened with 80 mesh screens
It is placed in the extraction kettle of supercritical extract；2) supercritical CO is used2As solvent, the ethyl alcohol of a concentration of 60%-80% is carried secretly
Agent；3) it adjusts extraction kettle to control extracting pressure in 5-15MPa, temperature control is at 30-50 DEG C, CO2Flow control is in 10-20L/
H, extraction time are controlled in 1-2h, obtain Radix Sophorae Flavescentis extractive liquid.
Specifically, dimethyl sulfoxide (DMSO), CAS：67-68-5；
Salicylic acid, CAS：69-72-7；
Benzoic acid：CAS：65-85-0；
Sodium chloride：CAS：7647-14-5；
Kuh-seng (Sophora flavescens) is purchased from Bozhou City Xin Yuan Chinese medicines Science and Technology Ltd.；
Peppermint (Mentha haplocalyx Briq), Bozhou City Golconda Chinese medicine sell Co., Ltd.
A kind of tinea of feet and hands treatment liquid provided by the invention has the following advantages compared with prior art：This product is used for the first time
It can relieve pain rapidly, is antipruritic；The skin corium that this product can also penetrate into skin kills the tinea bacterium of deep layer, while softening epidermidosis dirt,
It all falls off after a week, exposes healthy skin；This product is using a kind of solvent that can be carried drug and penetrate into deep tissues, and energy is thorough
Kill the tinea bacterium for being present in skin histology nerve root in bottom.This product is packaged into spray, simple, convenient, fast.Infect less serious case
Two times a day, the same day takes effect.Severe one is infected, is cured in one week, short treating period does not bother.
Specific implementation mode
With reference to embodiment, the present invention is described in further detail, and following embodiment is merely illustrative this
Invention, is not intended to limit the present invention.
Embodiment 1
The present embodiment provides a kind of tinea of feet and hands to treat liquid, including following component：Dimethyl sulfoxide (DMSO) 45g, Radix Sophorae Flavescentis extractive liquid
20g, peppermint extracting solution 20g, salicylic acid 4.1g, benzoic acid 10g, sodium chloride 0.9g.
Wherein, the manufacture craft of the peppermint extracting solution is 1) that dry peppermint grass meal is broken, is screened with 80 mesh screens
It is placed in the extraction kettle of supercritical extract；2) supercritical CO is used2As solvent, a concentration of 75% ethyl alcohol does entrainer；
3) it adjusts extraction kettle to control extracting pressure in 9MPa, temperature control is at 40 DEG C, CO2Flow control is in 15L/h, extraction time control
System obtains peppermint extracting solution in 1h.
The manufacture craft of the Radix Sophorae Flavescentis extractive liquid is：1) dry kuh-seng crushing 80 mesh screens screening is placed on super
In the extraction kettle of critical extraction；2) supercritical CO is used2As solvent, the ethyl alcohol of a concentration of 60%-80% does entrainer；3) it adjusts
It saves extraction kettle to control extracting pressure in 5-15MPa, temperature control is at 30-50 DEG C, CO2Flow control is in 10-20L/h, extraction
Time control obtains Radix Sophorae Flavescentis extractive liquid in 1-2h.
Embodiment 2
The present embodiment provides a kind of tinea of feet and hands to treat liquid, including following component：Dimethyl sulfoxide (DMSO) 45g, peppermint extracting solution
40g, salicylic acid 4.1g, benzoic acid 10g, sodium chloride 0.9g.
Wherein, the manufacture craft of the peppermint extracting solution is 1) that dry peppermint grass meal is broken, is screened with 80 mesh screens
It is placed in the extraction kettle of supercritical extract；2) supercritical CO is used2As solvent, a concentration of 75% ethyl alcohol does entrainer；
3) it adjusts extraction kettle to control extracting pressure in 9MPa, temperature control is at 40 DEG C, CO2Flow control is in 15L/h, extraction time control
System obtains peppermint extracting solution in 1h.
Embodiment 3
The present embodiment provides a kind of tinea of feet and hands to treat liquid, including following component：Dimethyl sulfoxide (DMSO) 45g, Radix Sophorae Flavescentis extractive liquid
40g, salicylic acid 4.1g, benzoic acid 10g, sodium chloride 0.9g.
Wherein, the manufacture craft of the Radix Sophorae Flavescentis extractive liquid is：1) dry kuh-seng is crushed after being screened with 80 mesh screens
It is placed in the extraction kettle of supercritical extract；2) supercritical CO is used2As solvent, the ethyl alcohol of a concentration of 60%-80% is carried secretly
Agent；3) it adjusts extraction kettle to control extracting pressure in 5-15MPa, temperature control is at 30-50 DEG C, CO2Flow control is in 10-20L/
H, extraction time are controlled in 1-2h, obtain Radix Sophorae Flavescentis extractive liquid.
Test case 1
External antimycotic test：
Experimental method is as follows：
This experiment accepted standard bacterial strain be acrothesium floccosum, Trichophyton rubrum and trichophyton gypseum, Candida albicans,
Center is preserved quoted from dermatological studies institute of Chinese Academy of Medical Sciences fungi strain.
The measurement of minimal inhibitory concentration (MCI)：Sterilizing test tubes 33 are taken to manage, wherein 1mL culture mediums are added in the 1st pipe, as life
Long control tube, the 2nd pipe are added 1mL positive drug ketone health mile (250mg/L) and are used as positive control pipe, the 3rd pipe that 1mL distilled water is added
As blank control pipe, 1 tinea of feet and hands of the example treatment liquid that 4-13 pipes are added after 1mL dilutions controls liquid, and concentration dilution ratio is l：
2、1：4、l：8、1：16、1：32、1：64、1：128、1：256、1：512, it totally 10 manages.The reality after 1mL dilutions is added in 14-23 pipes
2 tinea of feet and hands of example treatment liquid controls liquid, and concentration dilution ratio is l：2、1：4、l：8、1：16、1：32、1：64、1：128、1：256、1：
512, it totally 10 manages.3 tinea of feet and hands of the example treatment liquid that 24-33 pipes are added after 1mL dilutions controls liquid, and concentration dilution ratio is l：2、1：
4、l：8、1：16、1：32、1：64、1：128、1：256、1：512, it totally 10 manages.
The preparation and inoculation of bacteria suspension:1 collarium of picking newly cultivates fungus colony (kind is in Sabouraud's agar culture medium) and is suspended
15min is vibrated in 2mL physiological saline, is allowed to mix well, its turbidity is adjusted to 105-106CFU/mL.Use micro sample adding appliance
Often pipe plus 50 μ L suspensions, the 3rd pipe are not added with, and mixing is put into 28 DEG C of incubator culture 7d, observes and records antibacterial result.Result judgement:
Complete non-growing previous pipe is determined as terminal by NCCLS scheme proposals.Growth control pipe only adds culture medium and bacterium solution, is not added with
Medicine, only when growth control pipe well-grown, other test tubes are increased with drug concentration gradient, then are just demonstrate,proved when bacterium growth gradient is suppressed
Bright success of the test.
It takes 0.05mL to be transferred to culture medium from the pipe for have bacteriostasis, is further cultured for 10d, observation sterilization result.With no bacterium colony
The minimum drug dose of growth is minimum bactericidal concentration (MBC).
The results are shown in table below：
According to upper table, tinea of feet and hands prepared by present invention treatment liquid for common tinea pedis fungi have it is stronger antibacterial and
Sterilizing ability, wherein the effect to Trichophyton rubrum is most strong, it is weaker to Candida albicans effect.Plant extract in embodiment 2
Liquid is for peppermint extracting solution compared to the Radix Sophorae Flavescentis extractive liquid in embodiment 3 for the sterilization energy of acrothesium floccosum and Trichophyton rubrum
Power is weaker, but then relatively strong for the sterilizing ability of trichophyton gypseum and Candida albicans.Peppermint extraction is taken in embodiment 1
Liquid and Radix Sophorae Flavescentis extractive liquid all have stronger sterilizing ability as plant extraction liquid to various fungies.
Test case 2
Clinical test：
On the basis of obtaining foundation by animal toxicology experiment and pharmacological effect experiment, under the premise of patient is voluntary,
It is 6 on probation, it is treated using we, 7 days as one therapeutic course.Diagnostic criteria and treatment standard reference《Clinical disease diagnosis is according to healing
Improvement standard》(Sun Chuanxing edits in the second edition, People's Medical Officer Press), in conjunction with the particularity of the present invention, it is clinical to formulate the present invention
Test of cure standard is cured:Symptom and sign completely disappear；Direct microscopy and culture fungi are daily each primary, cloudy twice in succession
Property.
It improves:Symptom and sign disappear substantially.In vain:Through two course for the treatment of symptoms and sign without any apparent change experimental method
As a result：
Female, 58 years old, retired employees were perplexed by tinea pedis for a long time, spray made of the product prepared using embodiment 3, and one
It sprays affected part twice, fully recovers within one week.
Female, 54 years old, grade teacher was previously used the drug of various treatment tinea pedis, recurrent exerbation, uses embodiment 3
Spray made of the product of preparation twice a day sprays affected part, two weeks, cures.
Female, 35 years old, secondary school teachers, spray made of the product prepared using embodiment 3 twice a day sprayed affected part,
It cures within 3 days.
Man, 53 years old, doctor used various therapies due to being foot ephidrosis in hospital, finally used embodiment
Spray made of 3 products prepared twice a day sprays affected part, detail improves.
Female, 55 years old, cleaner, it is often necessary to wear rubber overshoes, foot, which blisters and very itches, feels bad, the production prepared using embodiment 3
Spray made of product twice a day sprays affected part, cures within one month.
Man, 45 years old, worker, one to summer, slippers can only be worn for a long time, sprayed made of the product prepared using embodiment 3
Agent twice a day sprays affected part, cures within 3 weeks.
In conclusion the present invention provides a kind of tinea of feet and hands to treat liquid, can effectively be overcome with quickly alleviating pain, antipruritic
The case where recurrent exerbation, short treating period are quick.
The foregoing is only a preferred embodiment of the present invention, is not intended to restrict the invention, for the skill of this field
For art personnel, the invention may be variously modified and varied.All within the spirits and principles of the present invention, any made by repair
Change, equivalent replacement, improvement etc., should all be included in the protection scope of the present invention.
Claims (6)
1. a kind of tinea of feet and hands treats liquid, which is characterized in that including following component：Dimethyl sulfoxide (DMSO), plant extraction liquid, salicylic acid,
Benzoic acid, sodium chloride.
2. tinea of feet and hands according to claim 1 treats liquid, which is characterized in that include following component by weight:Diformazan
30-60 parts of base sulfoxide, 40 parts of plant extraction liquid, 2-10 parts of salicylic acid, 5-20 parts of benzoic acid, 0.5-2 parts of sodium chloride.
3. tinea of feet and hands according to claim 1-2 any one treats liquid, which is characterized in that the plant extraction liquid is
Radix Sophorae Flavescentis extractive liquid or peppermint extracting solution or both arbitrary proportion mixed extract.
4. tinea of feet and hands according to claim 3 treats liquid, which is characterized in that the plant extraction liquid extracts for kuh-seng
Liquid：Peppermint extracting solution mass ratio is 1:1 mixed extract.
5. tinea of feet and hands according to claim 3 treats liquid, which is characterized in that the manufacture craft of the peppermint extracting solution
For：1) broken screened with 80 mesh screens of dry peppermint grass meal is placed in the extraction kettle of supercritical extract；2) using overcritical
CO2As solvent, the ethyl alcohol of a concentration of 60%-80% does entrainer；3) extraction kettle is adjusted to control extracting pressure in 5-
15MPa, temperature control is at 30-50 DEG C, CO2Flow control obtains peppermint extraction in 10-20L/h, extraction time control in 1-2h
Liquid.
6. tinea of feet and hands according to claim 3 treats liquid, which is characterized in that the manufacture craft of the Radix Sophorae Flavescentis extractive liquid
For：1) dry kuh-seng is crushed and is placed in the extraction kettle of supercritical extract with the screening of 80 mesh screens；2) supercritical CO is used2
As solvent, the ethyl alcohol of a concentration of 60%-80% does entrainer；3) extraction kettle is adjusted to control extracting pressure in 5-15MPa, temperature
Degree control is at 30-50 DEG C, CO2Flow control is controlled in 10-20L/h, extraction time in 1-2h, obtains Radix Sophorae Flavescentis extractive liquid.
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| CN201810577602.1A CN108392515A (en) | 2018-06-07 | 2018-06-07 | A kind of tinea of feet and hands treatment liquid |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201810577602.1A CN108392515A (en) | 2018-06-07 | 2018-06-07 | A kind of tinea of feet and hands treatment liquid |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112494533A (en) * | 2020-12-11 | 2021-03-16 | 毛善芳 | Traditional Chinese medicine for treating hand and foot skin diseases and preparation method thereof |
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| CN101502580A (en) * | 2009-03-20 | 2009-08-12 | 汪世龙 | External-use medicament for treating tinea manus and pedis |
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