CN207125908U - For coronary disease and angina pectoris paster - Google Patents

Abstract

The utility model discloses the technical field for for coronary disease and angina pectoris paster, belonging to external application coronary disease and angina pectoris Chinese medicine.The utility model will solve existing angina pectoris emplastrum and the technical problem for sticking that acupuncture point is more, the docile time is short, patient receives difficulty, and treatment total effective rate has much room for improvement be present.The utility model, which is used for coronary disease and angina pectoris paster, includes nonwoven layer and the medicine layer being arranged in nonwoven layer, and described medicine layer is made of compound danshen dripping pills.The application method of paster described in the utility model is sticked on SHENQUE acupoint.The utility model paster pastes that acupuncture point is few, application time is long, is not required to frequently change, easy to patients, and treatment total effective rate is up to 96.66%.

Description

For coronary disease and angina pectoris paster

Technical field

The utility model belongs to the technical field of external application coronary disease and angina pectoris Chinese medicine；It is particularly used for coronary disease and angina pectoris Paster.

Background technology

" Chinese cardiovascular disease report in 2015 " issue, cardiovascular disease occupy more than the 40% of people's disease death composition, agriculture Village is 44.6%, city be 42.51% be China resident the first cause of the death.Cardiovascular disease burden increasingly aggravates, it has also become great Public health problem.Coronary atherosclerotic heart disease (coronary heart disease) is most common angiocardiopathy.In recent years, with Living-pattern preservation, the incidence of disease of coronary heart disease is in the trend risen year by year, China's new premature coronary heart disease event (including urgency every year Property myocardial infarction, sudden death of coronary heart disease and chronic coronary are dead) about 1,300,000 times.The treatment of coronary heart disease has oral medication to come of age Pulsation frame two ways.Coronary artery bracket is costly, and long-term effect is unknown.Oral medication is still the first choice for treating coronary heart disease at this stage Method.Angina pectoris is the most important clinical symptoms of coronary heart disease, and reduces patients ' life quality, the main original for promoting it to see a doctor Cause.To allevating angina pectoris, clinically main drug application, other relevant external application methods are reported less.

Liaoning University of TCM Chen Wei reports in 2010, coronary heart disease stable angina pectoris is treated using angina pectoris emplastrum.Control Treatment group control group includes 80 patients for meeting diagnosis altogether.Angina pectoris emplastrum is by a few herbs or alcoholization and water boiling concentration medicine Some drugs powder is added, and base fat bleeding agent makes cream, uses interior pass, Xinshu, Danzhong, Zusanli, rich and prosperous totally 5 caves outside On position；The prescription sticks that acupuncture point is more, and application time is short, and patient receives difficult；To pectoralgia alleviate total effective rate be only 89.47%, it need to be improved.

Utility model content

The utility model is based on the external application method for clinically lacking treatment coronary disease and angina pectoris at this stage, and this practicality is new in addition Type will solve existing angina pectoris emplastrum, and in the presence of sticking, acupuncture point is more, application time is short, patient receives difficult, treatment total effective rate The technical problem having much room for improvement；And provide for coronary disease and angina pectoris paster.

It is used for coronary disease and angina pectoris paster in order to solve the above technical problems, of the present utility model, including nonwoven layer 1 and sets Put the medicine layer 6 in nonwoven layer 1, it is characterised in that described medicine layer 6 is made of compound danshen dripping pills.

The paster also includes adhesive layer 2, and adhesive layer 2 is arranged between nonwoven layer 1 and medicine layer 6.

The paster also includes impervious barrier 3 and annular groove 5, and impervious barrier 3 is set on adhesive layer 2, annular is set on impervious barrier 3 Groove 5, annular groove 5 is interior to set medicine layer 6.

One edge of the adhesive layer 2 sets adhering-resistant paper slip 4.

The top of the paster sets separation layer 7 made of paper.

Preparation method for coronary disease and angina pectoris paster is heated after compound danshen dripping pills is ground into 70 mesh fine powders Limber up, then be bonded in annular groove 5.

Contain compound danshen dripping pills 5~10 per note.

The above-mentioned application method for coronary disease and angina pectoris paster is to be sticked on SHENQUE acupoint, once a day, is held It is continuous to stick.Two weeks is a course for the treatment of.

The utility model is compound danshen dripping pills to be ground into fine powder cave note is made again, is applied on patient's SHENQUE acupoint, Effectively alleviate coronary disease and angina pectoris.

Compound danshen dripping pills put goods on the market in 1996, was turning into the routine of clinical treatment coronary disease and angina pectoris Medication.To the end of the year in 2016, day scholar's power compound danshen dripping pills will will also turn into the comprehensively by the clinic certification of three phase of U.S. FDA One Chinese medicine gone abroad.For the angle of the traditional Chinese medical science, the prescription compatibility of compound danshen dripping pills plays the role of to bring out the best in each other.Monarch The medicine red sage root is promoting blood circulation and removing blood stasis, blood-nourishing calming heart, and wide chest analgesic, ministerial drug pseudo-ginseng has dual regulation to blood coagulation system, and the stasis of blood is not stayed in hemostasis, Promoting blood circulation not bleeding, removing blood stasis and hemostasis, analgesic therapy of invigorating blood circulation, borneol have fragrance to walk to alter as adjuvant, chest qi, without the past work not reached With.The medical substance of compound danshen dripping pills is by made from lower column processing：Learn from else's experience the red sage root, the pseudo-ginseng of crushing, add water extraction Take 3 times, by filtering, filtrate decompression is concentrated, ethanol is added into concentrate, form precipitation；It will concentrate, be made thick on ethanol Cream, as medical substance；Borneol in prescription is pure compound, as long as crushing.Three kinds of components matchings have 1+1 together +1>3 effect, that is, take compound danshen dripping pills than and meanwhile take the red sage root and add pseudo-ginseng effect on the rocks good.Danshensu is from the red sage root In water soluble ingredient extract, there is protection cardiac muscle, antithrombus formation, protection nerve cell etc. to act on.Extract in pseudo-ginseng Active ingredient arasaponin, bioavilability are high.Borneol is natural borneol, and content is low, small to stomach stimulation, and then gesture of walking alone is weak, Assistant makes then active.

Paster medicine layer of the present utility model is in solid-state molecular dispersion, and the molecular state of effective ingredient is directly divided Dissipate in matrix, under body temperature effect, medicine layer melting, for decoction into transparence, the active ingredient molecule in medicine layer passes through god Fault cave is infiltrated through in human body, is quickly absorbed by the body, and into can discharge rapidly in vivo, active ingredient is through umbilical region Sweat glands channel, angle Matter layer and epidermis are transported into cytoplasm, and quick disperse enters capillary, successively through venae parumbilicales, portal vein, liver, Inferior caval vein reaches heart, is advantageous to fully absorb and plays curative effect.The utility model overcomes conventional solid Chinese medicine preparation and risen The deficiency that effect is slow, drug effect is low, there is the characteristics of quick-acting.

This therapeutic modality of the utility model point-application has effectively evaded the first pass effect of liver, and without suffering from Person takes medicine repeatedly, and the compliance of patient is high.

Paster of the present utility model can substantially mitigate the degree of pectoralgia after sticking, reduce the number of breaking-out.

The utility model has filled up the blank of coronary disease and angina pectoris Topical therapy.Fully apply present coronary heart disease treatment field In compound danshen dripping pills curative for effect, effective innovation has been carried out to its usage.Oral administered compound Danshen Root dropping ball treats coronary heart disease Anginal total effective rate can also reach more than 90%, and the compliance that crucial patient takes oral medicine and needs it higher just can guarantee that Curative effect.Ensure the effective blood drug concentration of oral drugs, there is high requirement to the compliance of patient medication, and the trouble of coronary heart disease Person group is often older, is a problem to patient on time by the guarantee medication paused, the utility model can effectively be evaded orally The disadvantages mentioned above of compound danshen dripping pills, paster of the present utility model stick once a day, and whole day is effective, easy to use, and its The advantage of dripping pill can also be brought into play, the effect of making full use of Fang Dan Shen Di Wan on coronary heart disease definite, be had higher Clinical efficacy, the shortcomings that effectively having evaded its frequent drug administration.

Paster of the present utility model meets the needs of vast patients with coronary heart disease, improves its quality of life, delays the hair of disease Exhibition, and control the generation of cardiovascular event；Good economic benefit and social benefit will be created.

It is i.e. effective within paster use one day after of the present utility model, it is adapted to prolonged application, has no side effect.This practicality is new Type will solve the problems, such as that existing angina pectoris emplastrum is present, and paste that acupuncture point is few, application time is long, is not required to frequently change, and be easy to patient Receive, treatment total effective rate is up to 96.66%.

Brief description of the drawings

Fig. 1 is the structural representation of paster described in the utility model, 1 in Fig. 1 --- nonwoven layer, 2 --- and adhesive layer, 3 --- impervious barrier, 4 --- adhering-resistant paper slip, 5 --- annular groove, 6 --- medicine layer, 7 --- separation layer made of paper；Fig. 2 is to suffer from Electrocardiogram before Liu's person treatment；Fig. 3 is electrocardiogram after patient Liu's treatment.

Embodiment

Embodiment one：Illustrated with reference to Fig. 1, the coronary disease and angina pectoris paster that is used for of present embodiment includes nothing Spin layer of cloth 1, medicine layer 6, adhesive layer 2, impervious barrier 3, adhering-resistant paper slip 4, annular groove 5 and separation layer made of paper 7, nonwoven layer 1 Upper setting adhesive layer 2, an edge of adhesive layer 2 set adhering-resistant paper slip 4, on adhesive layer 2 among impervious barrier 3 is set, prevent Annular groove 5 is set on infiltration layer 3, the outward flange of impervious barrier 3 is concordant with the outward flange of annular groove 5, and medicine layer 6 is set in annular groove 5, The top sets separation layer 7 made of paper；The compound danshen dripping pills that described medicine layer 6 is produced by Tianjin Tian Shili groups is made 's.

Preparation method for coronary disease and angina pectoris paster is will to be heated after 8 mesh of compound danshen dripping pills grind into powder 70 Limber up, then be bonded in annular groove 5.

Using following verification experimental verification utility model effects：

Select Treating Stable Angina Pectoris of Coronary Artery Disease type of obstruction of heart-blood patient 60.Western medicine diagnostic criteria reference《The instability mode heart Angina diagnoses and treatment recommendations》(angiocardiology branch of Chinese Medical Association version in 2000), tcm diagnosis standard was with reference to 2002 Promulgate《New Chinese medicine treats the obstruction of qi in the chest (coronary disease and angina pectoris) guideline of clinical investigations》.Inclusive criteria：1. the age 50~ Inpatient between 70 years old.2. Western medicine diagnostic criteria meets the patient of unstable angina pectoris of coronary heart disease.4. voluntarily and signature is known Feelings letter of consent.Exclusion standard (meets following any one person)：1. making a definite diagnosis on inspection with coronary heart disease acute myocardial infarction, or have Degree, severe angina pectoris and serious cardiac disorder, severe neurological functional disease, hyperthyroidism, cervical spondylopathy, Climacteric and stomach food Pipe backflows caused chest pain patients.2. merge severe arrhythmia cordis (atrial fibrillation, room are flutterred, paroxysmal room speed etc.), severe cardio-pulmonary function not Entirely, severe hypertension (III level) patient.3. having participated in other clinical experimental studies in three months, this result of study may be influenceed Patient.60 patients are randomly divided into seminar and control group, seminar 30, male 15, women according to hospital order 15, max age 70 years old is minimum 50 years old, average age 60.87 ± 6.37 years old.Control group 30, male 19, women 11 Example, max age 70 years old is minimum 50 years old, and average age is 61.63 ± 5.87 years old.Through statistical analysis, the year of two groups of patients No significant difference in terms of age, sex, the course of disease, the layering of risk factor degree, has comparativity.

Method

1. treatment method

Seminar：Patch on the basis of the stable angina cordis doctor trained in Western medicine Primary Care described in use in conjunction embodiment one Piece；Contain compound danshen dripping pills 8 per note, a little honey is added after crushing, sky is adhered to and sticks.The easypro Shenque note of the heart sticks on Shenque On cave, once a day, persistently stick.Two weeks is a course for the treatment of.

Control group：Doctor trained in Western medicine Primary Care is awarded, SHENQUE acupoint docile starch adds cave note made of honey.Once a day, continue Stick.Two weeks is a course for the treatment of.

2. evaluation index

Pass through before intervening and after intervening 2 weeks on the basis of safety indexes (blood, routine urinalysis, liver function, renal function) Analysis health giving quality index are tested and assessed to two groups of patients.Wherein, health giving quality index include as follows：

2.1 Chinese medicine syndrome integral:Reference《New Chinese medicine guideline of clinical investigations》In the standard formulation of (version in 2002) Cure therapeutic effect of syndrome criterion.

2.2 coronary disease and angina pectoris are scored：Reference《New Chinese medicine treats the guideline of clinical investigations of coronary disease and angina pectoris》 (Ministry of Health of the People's Republic of China issues for 2002).

2.3 ECG curative effects are evaluated：Reference《Coronary disease and angina pectoris and ECG curative effect criterion》(in September, 1979, on Sea).

2.4 nitroglycerins stop lapse rate criterion:Stop lapse rate：(treatment before with after tablet number-treatment with tablet number)/treatment Preceding tablet number × 100%.

3 statistical methods

The data that this experiment obtains is established into database, data analysis and processing are carried out using SPSS19.0 softwares.It is quantitative Data with Represent；Fixed number data with frequency ratio, formed table and represented.For meeting normal distribution person, with pretherapy and post-treatment in group Compare paired t-test method of taking, compare between group and take independent samples t test method.For not meeting normal distribution person, take Non-parametric test method, ranked data use χ²Examine.The difference of each group index in the case of two kinds of analysis treatment group and control group Property, P>0.05 is not statistically significant, P<0.05 has notable difference, P<0.01 has significant difference.

As a result

1. the comparison of two groups of patient's ordinary circumstances before intervening

There was no significant difference in terms of the ordinary circumstance of two groups of patients, the course of disease, risk factor layering, has comparativity (P> 0.05).It is shown in Table 1.

1 two groups of patient's ordinary circumstances of table compare

¹⁾For χ²Value,²⁾For t values

2. two groups of patient's disease integrations of patients before and after intervention compare

There was no significant difference for two groups of tcm clinical practice syndrome integrals before treatment, P=0.755>0.05 has comparativity, before treatment Two groups more have significant difference P=0.00 afterwards<0.01；Compare P=0.036 between two groups after treatment<0.05, there is statistics Meaning, illustrate on tcm clinical practice therapeutic effect of syndrome, seminar is substantially better than control group.It is shown in Table 2.

2 two groups of patient's patients before and after intervention symptom integrals of table compare

3. the pretherapy and post-treatment angina pectoris symptom curative effect of two groups of patients compares

Statistical result showed, angina pectoris attacks number, the duration, pain degree is scored through non-parametric test, before treatment P>0.05, no significant difference, there is comparativity；Compare after treatment between group, P<0.05, there is notable difference, illustrate Treatment group is substantially better than control group in terms of improving angina pectoris symptom；Relatively P in group before and after treatment<0.01, there is significant difference, Angina pectoris symptom can be obviously improved by illustrating two groups.It is shown in Table 3.

The pretherapy and post-treatment angina pectoris symptom integral contrast of 3 two groups of patients of table

4. two groups of ECG curative effects compare after intervening

By the treatment of two weeks, with the total effective number of cases of two groups of Chi-square Test, as a result show P=0.937, there was no significant difference (P ＞ 0.05), without statistical significance.Illustrate two groups on ECG curative effect, no significant difference.It is shown in Table 4.

Two groups of patient ECG's curative effects compare after table 4 is intervened 2 weeks

5. two groups of nitroglycerins subtract the rate of stopping and compared after intervening

By the treatment of two weeks, 30 patients of seminar before the treatment by taking nitroglycerin allevating angina pectoris, After treatment, it is 9 that nitroglycerin, which is discontinued, subtracts medicine as 18；It is sweet that 30 patients of control group also take nitric acid before the treatment Oily allevating angina pectoris, after treatment, 5 patients can be discontinued, and 14 can reduce nitroglycerin consumption.It is statistically analyzed, nitric acid is sweet The effect of You Ting lapse rate treatment groups, is substantially better than control group (P=0.045, P<0.05).It is shown in Table 5.

Two groups of patient's nitroglycerins subtract the rate of stopping and compared after table 5 is intervened 2 weeks

Present illness history：Patient is because weather reason occurred paroxysmal pain uncomfortable in chest before 20 days, with dizziness and nausea, exacerbation in nearly one week.From Tell and " coronary disease and angina pectoris " " hypertension " was diagnosed as in 1987.The row coronary artery CT of row 320 in 2012, as a result show " in descending anterior branch- Severe stenosis, arteria coronaria dextra severe stenosis ", it is proposed that row percutaneous transluminal coronary stent implantation, because of lidocaine allergy, do not do intervention and control Treat.Long-term Oral visits aspirin, Valsartan, isosorbide dinitrate etc..There is pain uncomfortable in chest within nearly 20 days, be radiated to back and left shoulder, slightly labor Send out, every time lasting a few minutes.

Patient's general state：T:36.7C P:60 beats/min of R：20 beats/min of BP：160th, 90mmHG minds are clear, and breathing is anxious Promote, have rosy cheeks, expression pain, edgy, blurred vision.Two is just normal.Electrocardiogram is as shown in Figure 2.

Diagnosis：Coronary atherosclerotic heart disease unstable angina pectoris.

3 grades of primary hypertension.

Principle of reatment：Anti-freezing, coronary dilatation, decompression, analgesic.

Medication：Low molecular sodium heparin 5000u days are once subcutaneously injected；5% glucose 250ml different Shu Ji 20mg days are once quiet Arteries and veins is infused；Aspirin 100mg days are once oral；Comfortable Shenque pastes point-application of day.

Prognosis：It is in hospital 20 days altogether, patient symptom is clearly better, and electrocardiogram ischemia symptom is alleviated, referring to Fig. 3.

Claims (4)

1. be used for coronary disease and angina pectoris paster, including nonwoven layer (1) and the medicine layer (6) that is arranged in nonwoven layer (1) its It is characterised by that described medicine layer (6) is made of compound danshen dripping pills；The paster also includes adhesive layer (2), impervious barrier (3) it is arranged on annular groove (5), adhesive layer (2) between nonwoven layer (1) and medicine layer (6)；Adhesive layer sets antiseepage on (2) Layer (3), annular groove (5) is set on impervious barrier (3), medicine layer (6) is set in annular groove (5).

2. according to claim 1 be used for coronary disease and angina pectoris paster, it is characterised in that the outward flange of impervious barrier (3) and ring The outward flange of shape groove (5) is concordant.

3. according to claim 1 or 2 be used for coronary disease and angina pectoris paster, it is characterised in that a side of adhesive layer (2) Edge sets adhering-resistant paper slip (4).

4. according to claim 3 be used for coronary disease and angina pectoris paster, it is characterised in that the top of the paster is set Separation layer (7) made of paper.