CN102670718A - Chinese medicine composition for treating cardiovascular and cerebrovascular diseases and preparation method of same - Google Patents
Chinese medicine composition for treating cardiovascular and cerebrovascular diseases and preparation method of same Download PDFInfo
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Abstract
The invention provides a Chinese medicine composition for treating cardiovascular and cerebrovascular diseases and a preparation method of same. The Chinese medicine composition comprises the following Chinese medicine raw materials as per part by weight: 1 to 10 parts of musk, 1 to 10 parts of bezoar, 20 to 40 parts of zsocys dhumnades, 10 to 30 parts of herba hedyotis diffusae, 1 to 10 parts of leech, 1 to 8 parts of crude pangolins, 2 to 6 parts of centipedes, 10 to 40 parts of tung grass, 5 to 20 parts of eupolyphaga, 5 to 11 parts of red flower, 20 to 50 parts of caulis spatholobi, 8 to 20 parts of ligusticum wallichii, 8 to 20 parts of bombys batryticatus, 10 to 22 parts of buffalo horn, 1 to 5 parts of processed semen strychni and 15 to 45 parts of summer purslane. The Chinese medicine composition has scientific and reasonable formula, solves the problems in the prior art, and realizes the advantages of having small taking dosage and toxic and side effects, treating both principal and secondary aspect of disease, treating and supplying symmutaneously, and being low in possibility for disease to recur when being used for treating cardiovascular and cerebrovascular diseases.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, relate in particular to a kind of Chinese medicine composition and method for preparing of treating cardiovascular and cerebrovascular disease.
Background technology
Cardiovascular and cerebrovascular disease is meant cardiovascular and cerebrovascular vessel generation pathological changes and causes the disease of heart and brain tissues blood supply disorder, is the particularly healthy important diseases of middle-aged and elderly people of a kind of harm humans health.Wherein cardiovascular disease mainly contains coronary heart disease and angina pectoris, and cerebrovascular disease is mainly hemorrhagic apoplexy and ischemic cerebrovascular.Coronary heart disease, myocardial ischemia, myocardial infarction, heart dysfunction, cerebral thrombosis and cerebral infarction etc. all are the diseases of high incidence, high relapse rate, high disability rate, have all brought huge financial burden for society and family.
Western medicine to cardiovascular and cerebrovascular diseases is many, and the treatment phase is short, but side effect is big, state of an illness easy relapse after the drug withdrawal, inaccessible curative effect.In recent years,, also occur the Chinese medicine preparation of some treatment cardiovascular and cerebrovascular vessel on the market, cure the symptoms, not the disease or cost an arm and a leg, can't satisfy vast cardiovascular and cerebrovascular disease patient's demand but have the most existence of Chinese medicine now along with going deep into of clinical research.
Summary of the invention
The invention provides a kind of Chinese medicine composition of treating cardiovascular and cerebrovascular disease, in order to solve the problems of prior art, realized that taking dose is little, treating both the principal and secondary aspects of a disease, control mend synchronously, toxic and side effects is little and the advantage of difficult recurrence.
In order to achieve the above object, a kind of Chinese medicine composition of treating cardiovascular and cerebrovascular disease provided by the invention comprises each component that weight proportion is following:
The source of said component can be a Chinese crude drug, or is equivalent to the Chinese medicine extract of above-mentioned Chinese crude drug crude drug amount.In the compositions of the present invention, can select the whole starch of flavour of a drug, form that also can extract is used as medicine, and has mainly comprised said components, and said composition can reach the drug effect of treatment cardiovascular and cerebrovascular disease.
Further, preferably comprise each component that weight proportion is following:
Further, preferred each component that comprises that weight proportion is following:
Further, also comprise pharmacy acceptable excipient substance.As prepare tablet and capsule filler starch commonly used, dextrin, Icing Sugar, lactose, calcium carbonate etc.
Further, said a kind of Chinese medicine composition of treating cardiovascular and cerebrovascular disease can be any dosage form, comprising: honeyed pill, water-honeyed pill, the watered pill, granule, capsule, tablet, powder, oral liquid or syrup.Powder preferably.
Chinese medicine thinks that cardiovascular and cerebrovascular disease is that blockage of main and collateral channels causes owing to disharmony between QI and blood.The present invention is mainly according to the dialectical principle of controlling of executing of Chinese medicine, and the natural Chinese medicine that screening is suited the medicine to the illness is by the theory of Chinese medical science prescription.Zaocys and Agkistrodon have dispelling wind and removing obstruction in the collateral in the prescription of the present invention, the effect of the dissolving thromboembolism factor.Hirudo and Scolopendra can play blood circulation promoting and blood stasis dispelling, detoxicating and resolving stagnation of pathogens, collateral dredging, analgesic effect to the treatment cardiovascular and cerebrovascular disease.Eupolyphaga Seu Steleophaga, Bombyx Batryticatus and Cornu Bubali are capable of blocking and destroy the thromboembolism factor and form.Semen Strychni can quicken the thromboembolism factor and dissolve.Radix Salviae Miltiorrhizae and Radix Cyathulae have the effect that blood circulation promoting and blood stasis dispelling, relieving restlessness are calmed the nerves.Cortex Acanthopancis and Radix Dipsaci can be regulated neural.Flos Carthami, Caulis Spatholobi and Rhizoma Chuanxiong mainly have enrich blood invigorate blood circulation, the effect of relaxing muscles and tendons and activating QI and blood in the collateral.Herba portulacae, Medulla Tetrapanacis function dredging vascellum bring high blood pressure down.Each component that the present invention adopted all plays certain effect in proportioning treatment cardiovascular and cerebrovascular disease, they have blood circulation promoting and blood stasis dispelling at comprehensive function, and dredging the meridian is removed thrombosis, steady blood pressure, and blood fat reducing makes the position mediation of obstruction.Directly act on diseased region after the medication, improve blood circulation, increase old metabolism of next year, make the cardiac and cerebral blood-supply oxygen supply.
Another object of the present invention is the method for preparing that the Chinese medicine composition of above-mentioned treatment cardiovascular and cerebrovascular disease also is provided, and can obtain being used to treating evident in efficacy, the sophisticated technologies of cardiovascular and cerebrovascular disease, stay-in-grade pharmaceutical composition through this method.
The method for preparing of the Chinese medicine composition of said treatment cardiovascular and cerebrovascular disease comprises the steps:
(1), said components is carried out selection, weighs, cleaned according to weight proportion;
(2), with Zaocys with spend calmy in vain with 60-100 degree water logging bubble 2-4 week, taking-up is dried;
Hirudo and Scolopendra were soaked 1-5 hour with vinegar, with the little Huang of 200-300 degree slow fire parch;
To give birth to Squama Manis and soak 6-16 hour, fry to little Huang with 300-600 degree slow fire with vinegar;
Use concentration to be 200-500g/L saline soak 2-10h Eupolyphaga Seu Steleophaga, Bombyx Batryticatus and Cornu Bubali,, stir-fried 40-80 minute with copper pot slow fire 200-300 degree;
Radix Salviae Miltiorrhizae and Radix Cyathulae are soaked 1-5h with vinegar,, stir-fried 20-60 minute with copper pot slow fire 100-400 degree;
(3), each component in Moschus, Calculus Bovis, Radix Dipsaci, Medulla Tetrapanacis, Flos Carthami, Caulis Spatholobi, Rhizoma Chuanxiong, Herba portulacae and the step (2) is mixed and pulverizing mistake 100-200 mesh sieve, extracting screen underflow.
Further, preferably may further comprise the steps:
(1), earlier said components is carried out selection, weighs, cleaned according to weight proportion;
(2), with Zaocys and spend in vain calmy with 80 the degree water loggings steeped for 2 weeks, taking-up is dried;
Hirudo and Scolopendra were soaked 2 hours with vinegar, with the little Huang of 200 degree slow fire parches;
To give birth to Squama Manis and soak 8 hours, fry to little Huang with 400 degree slow fire with vinegar;
Use concentration to be 300g/L saline soak 5h Eupolyphaga Seu Steleophaga, Bombyx Batryticatus and Cornu Bubali,, stir-fried 60 minutes with copper pot slow fire 200 degree;
Radix Salviae Miltiorrhizae and Radix Cyathulae are soaked 2h with vinegar,, stir-fried 30 minutes with copper pot slow fire 300 degree;
(3), each component in Moschus, Calculus Bovis, Radix Dipsaci, Medulla Tetrapanacis, Flos Carthami, Caulis Spatholobi, Rhizoma Chuanxiong, Herba portulacae, Semen Strychni (processed) and the step (2) is mixed and pulverizing mistake 100-200 mesh sieve, extracting screen underflow.
Further, said Semen Strychni (processed) is that said Semen Strychni detoxicating method is following: Semen Strychni is soaked 50-90 minute in water after, under the 600-1200 degree, fry out white cigarette with Semen Strychni detoxification 4-8 time.
Further, said Semen Strychni (processed) is that said Semen Strychni detoxicating method is following with Semen Strychni detoxification 6 times: Semen Strychni is soaked 60 minutes in water after, under 800 degree, fry out white cigarette.
One, acute toxicity testing
Get 20 of healthy rats, every about 50-100 gram, random packet, 20 every group, 5 times and 10 times of administrations of pressing the human body formulation rate respectively.Long-term clinical experiment result shows that this Chinese medicine is to rats eating amount, hair growth through animal; Breath cycle, defecate etc. do not have obviously influence, each item physiochemical indice; Organ coefficient and biochemical measurement index are compared with matched group; No significant difference is not found toxicity target cell organ, explains that this medical instrument has higher safety.
Two, clinical trial:
Patient's 62 examples such as clinical treatment cerebral thrombosis of the present invention, coronary heart disease and hypertension, wherein, man's 30 examples, woman's 32 examples, age 40-80 year, 65 years old mean age.
Usage and dosage: first month, three times on the one, a 9g;
The second month and three month, every day twice, 9g;
Warm boiled water before morning and the lunch, evening is warm boiled water after meal,
Three months is a course of treatment, takes four courses of treatment altogether.
Efficacy assessment standard: the present invention mainly treats and is used to treat cardiovascular and cerebrovascular disease, so doing well,improving situation and each item detect index as curative effect judging standard, cure: symptom all disappears, and main physics and chemistry detects index and is normally.Significantly: symptomatology is eliminated or cardinal symptom is eliminated, and it is normal basically that physics and chemistry detects index, can not leave the bed or can not walking freely the walking that after treatment, affranchises, but shakiness not too on foot before treating like the hemiplegic patient.
Diagnosis basis: coherence checks such as the heart and brain coloured silk is ultra, electrocardiogram, CT sheet.
Clinical test results shows that the present invention has better therapeutic effect, cures 56 examples; Remarkable six examples, and can obviously improve the tcm clinical practice disease.Cure rate reaches 90%, and total effective rate reaches 100%, has popularizing application prospect preferably.
Beneficial effect of the present invention:
1, the present invention's Chinese medicine composition of treating thromboembolism can be used for treating cardiovascular and cerebrovascular disease.Be mainly used in treatment by the heart and brain venation stasis of blood stagnates, arteriosclerosis causes coronary heart disease, myocardial infarction, cerebral thrombosis, cerebral infarction, hemiplegia, aphasia meter apoplexy sequela, can also alleviate the untoward reaction of cerebral hemorrhage convalescent period appearance.
2, this medicine can improve the cardio-cerebrovascular function, and adjustment heart blood supply, oxygen supply balance to the control cardiovascular and cerebrovascular disease, like coronary heart disease, attack ischemia, and cardiovascular disease such as cerebral ischemia are significant.
3, the experimental result through the adjuvant teaching shows that this medicine can obviously suppress in the rat body, outer thrombosis, and anticoagulant reduces blood viscosity, and blood fat reducing improves anti-anoxia ability.
4, the clinical use of the present invention proves, instant effect reaches about 90% the cardiovascular and cerebrovascular disease cure rate, and total effective rate reaches 100%.
The specific embodiment
Embodiment one
The Chinese medicine composition of the disclosed treatment cardiovascular and cerebrovascular disease of present embodiment comprises each component that weight proportion is following:
Dosage form of the present invention is for being powder, and the Chinese medicine composition that is appreciated that the described treatment cardiovascular and cerebrovascular disease of present embodiment can also be other any dosage forms, like honeyed pill, water-honeyed pill, the watered pill, granule, capsule, tablet, oral liquid or syrup.
The method for preparing of the Chinese medicine composition of above-mentioned treatment cardiovascular and cerebrovascular disease comprises the steps:
(1), earlier said components is carried out selection, weighs, cleaned according to weight proportion;
(2), with Zaocys and spend in vain calmy with 80 the degree water loggings steeped for 2 weeks, taking-up is dried;
Hirudo and Scolopendra were soaked 2 hours with vinegar, with the little Huang of 200 degree slow fire parches;
To give birth to Squama Manis and soak 8 hours, fry to little Huang with 400 degree slow fire with vinegar;
Use concentration to be 300g/L saline soak 5h Eupolyphaga Seu Steleophaga, Bombyx Batryticatus and Cornu Bubali,, stir-fried 60 minutes with copper pot slow fire 200 degree;
Radix Salviae Miltiorrhizae and Radix Cyathulae are soaked 2h with vinegar,, stir-fried 30 minutes with copper pot slow fire 300 degree;
(3), each component in Moschus, Calculus Bovis, Radix Dipsaci, Medulla Tetrapanacis, Flos Carthami, Caulis Spatholobi, Rhizoma Chuanxiong, Herba portulacae, Semen Strychni (processed) and the step (2) is mixed and pulverizing mistake 100-200 mesh sieve, extracting screen underflow.
Semen Strychni (processed) is with Semen Strychni detoxification 6 times, the Semen Strychni detoxicating method: Semen Strychni is soaked 60 minutes in water after, under 800 degree, fry out white cigarette.
The said Chinese medicine of present embodiment is cured case for example:
Liao, man, 61 years old.Main suit: can't take care of oneself, hemiplegia.Examine symptom in fact: consciousness and visual disorder, hemiplegia, a side sensory disturbance, movement disorder is diagnosed as cerebral thrombosis.Take the Chinese medicine composition of the said treatment cardiovascular and cerebrovascular disease of present embodiment, take continuously four courses of treatment (individual altogether month an of course of treatment: first month, three times on the one, a 9g; Second month and March, twice, one time on the one 9g; Warm boiled water before morning and the lunch, evening is warm boiled water after meal.)。Above-mentioned symptom all disappears, recovery from illness.And in therapeutic process, there are not liver, kidney, stomach, the uncomfortable phenomenon of spleen.
Embodiment two
The Chinese medicine composition of the disclosed treatment cardiovascular and cerebrovascular disease of present embodiment comprises each component that weight proportion is following:
The Chinese medicine composition of present embodiment treatment cardiovascular and cerebrovascular disease is prepared into tablet, wherein is added with in filler starch, dextrin, Icing Sugar, lactose and the calcium carbonate one or more.
The method for preparing of the Chinese medicine composition of above-mentioned treatment cardiovascular and cerebrovascular disease comprises the steps:
(1), earlier said components is carried out selection, weighs, cleaned according to weight proportion;
(2), with Zaocys and spend in vain calmy with 60 the degree water loggings steeped for 4 weeks, taking-up is dried;
Hirudo and Scolopendra were soaked 1 hour with vinegar, with the little Huang of 300 degree slow fire parches;
To give birth to Squama Manis and soak 16 hours, fry to little Huang with 300 degree slow fire with vinegar;
Use concentration to be 200g/L saline soak 10h Eupolyphaga Seu Steleophaga, Bombyx Batryticatus and Cornu Bubali,, stir-fried 80 minutes with copper pot slow fire 300 degree;
Radix Salviae Miltiorrhizae and Radix Cyathulae are soaked 1-5h with vinegar,, stir-fried 60 minutes with copper pot slow fire 100 degree;
(3), each component in Moschus, Calculus Bovis, Radix Dipsaci, Medulla Tetrapanacis, Flos Carthami, Caulis Spatholobi, Rhizoma Chuanxiong, Herba portulacae, Semen Strychni (processed) and the step (2) is mixed and pulverizing mistake 100-200 mesh sieve, extracting screen underflow.
Semen Strychni (processed) is that the Semen Strychni detoxicating method is following with Semen Strychni detoxification 4 times: Semen Strychni is soaked 50 minutes in water after, under 1200 degree, fry out white cigarette.
The said Chinese medicine of present embodiment is cured case for example:
Feng, the woman 49 years old, suffered from hypertension 10 years, not conventional medication treatment.Main suit: cardiopalmus, chest pain occur and seek medical advice.Examine symptom in fact: pain uncomfortable in chest, cardiopalmus, perspiration, supernatural power, dizziness; Blood pressure 17090mmHg; The electrocardio diagram, inferior myocardial ischemia; Blood fat; Cholesterol 7.5ml/L is diagnosed as coronary heart disease, angina pectoris.Take the Chinese medicine composition of the said treatment cardiovascular and cerebrovascular disease of present embodiment, take continuously a course of treatment (three totally months: first month, three times on the one, a 9g; Second month and March, twice, one time on the one 9g; Warm boiled water before morning and the lunch, evening is warm boiled water after meal.)。Above-mentioned symptom all disappears, recovery from illness.Follow up a case by regular visits to not recurrence in 3 months.And in therapeutic process, there are not liver, kidney, stomach, the uncomfortable phenomenon of spleen.
Embodiment three
The Chinese medicine composition of the disclosed treatment cardiovascular and cerebrovascular disease of present embodiment comprises each component that weight proportion is following:
The Chinese medicine composition of present embodiment treatment cardiovascular and cerebrovascular disease is a capsule, wherein is added with filler starch, dextrin, Icing Sugar, lactose, calcium carbonate or other pharmacy acceptable excipient substances.
The method for preparing of the Chinese medicine composition of above-mentioned treatment cardiovascular and cerebrovascular disease comprises the steps:
(1), earlier said components is carried out selection, weighs, cleaned according to weight proportion;
(2), with Zaocys and spend in vain calmy with 100 the degree water loggings steeped for 2 weeks, taking-up is dried;
Hirudo and Scolopendra were soaked 3 hours with vinegar, with the little Huang of 250 degree slow fire parches;
To give birth to Squama Manis and soak 10 hours, fry to little Huang with 500 degree slow fire with vinegar;
Use concentration to be 400g/L saline soak 2h Eupolyphaga Seu Steleophaga, Bombyx Batryticatus and Cornu Bubali,, stir-fried 60 minutes with copper pot slow fire 250 degree;
Radix Salviae Miltiorrhizae and Radix Cyathulae are soaked 1-5h with vinegar,, stir-fried 40 minutes with copper pot slow fire 300 degree;
(3), each component in Moschus, Calculus Bovis, Radix Dipsaci, Medulla Tetrapanacis, Flos Carthami, Caulis Spatholobi, Rhizoma Chuanxiong, Herba portulacae, Semen Strychni (processed) and the step (2) is mixed and pulverizing mistake 100-200 mesh sieve, extracting screen underflow.
Semen Strychni (processed) is that the Semen Strychni detoxicating method is following: Semen Strychni is soaked 50-90 minute in water after, under the 600-1200 degree, fry out white cigarette with Semen Strychni detoxification 4-8 time.
The said Chinese medicine of present embodiment is cured case for example:
The Wang, woman, 55 years old.Main suit: aphasia, facial hemiparalysis, can not take care of oneself and seek medical advice.Be diagnosed as apoplectic hemiplegia.Take the Chinese medicine composition of the said treatment cardiovascular and cerebrovascular disease of present embodiment, take continuously three courses of treatment (three months course of treatment: first month, three times on the one, a 9g; Second month and March, twice, one time on the one 9g; Warm boiled water before morning and the lunch, evening is warm boiled water after meal.)。Above-mentioned symptom all disappears, and walking is normal, normal in a minute, can be from the general housework of practical work.Follow up a case by regular visits to not recurrence after half a year.
What should explain at last is: above each embodiment is only in order to explaining technical scheme of the present invention, but not to its restriction; Although the present invention has been carried out detailed explanation with reference to aforementioned each embodiment; Those of ordinary skill in the art is to be understood that: it still can be made amendment to the technical scheme that aforementioned each embodiment put down in writing, perhaps to wherein part or all technical characteristic are equal to replacement; And these are revised or replacement, do not make the scope of the essence disengaging various embodiments of the present invention technical scheme of relevant art scheme.
Claims (8)
1. a Chinese medicine composition of treating cardiovascular and cerebrovascular disease is characterized in that, comprises each component that weight proportion is following:
2. according to the Chinese medicine composition of the said treatment cardiovascular and cerebrovascular disease of claim 1, it is characterized in that, comprise each component that weight proportion is following:
3. according to the Chinese medicine composition of the said treatment cardiovascular and cerebrovascular disease of claim 2, it is characterized in that, comprise each component that weight proportion is following:
4. according to the Chinese medicine composition of the said treatment cardiovascular and cerebrovascular disease of claim 1, it is characterized in that, also comprise pharmacy acceptable excipient substance.
5. according to the Chinese medicine composition of the said treatment cardiovascular and cerebrovascular disease of claim 1, it is characterized in that its dosage form is: honeyed pill, water-honeyed pill, the watered pill, granule, capsule, tablet, powder, oral liquid or syrup.
6. the method for preparing of the Chinese medicine composition of any said treatment cardiovascular and cerebrovascular disease of claim 1-5 is characterized in that, comprises the steps:
(1), said component is carried out selection, weighs, cleaned according to weight proportion;
(2), with Zaocys with spend calmy in vain with 60-100 degree water logging bubble 2-4 week, taking-up is dried;
Hirudo and Scolopendra were soaked 1-5 hour with vinegar, with the little Huang of 200-300 degree slow fire parch;
To give birth to Squama Manis and soak 6-16 hour, fry to little Huang with 300-600 degree slow fire with vinegar;
Use concentration to be 200-500g/L saline soak 2-10h Eupolyphaga Seu Steleophaga, Bombyx Batryticatus and Cornu Bubali,, stir-fried 40-80 minute with copper pot slow fire 200-300 degree;
Radix Salviae Miltiorrhizae and Radix Cyathulae are soaked 1-5h with vinegar,, stir-fried 20-60 minute with copper pot slow fire 100-400 degree;
(3), each component in Moschus, Calculus Bovis, Radix Dipsaci, Medulla Tetrapanacis, Flos Carthami, Caulis Spatholobi, Rhizoma Chuanxiong, Herba portulacae, Semen Strychni (processed) and the step (2) is mixed and pulverizing mistake 100-200 mesh sieve, extracting screen underflow.
7. according to the said method for preparing of claim 6, it is characterized in that said Semen Strychni (processed) is that said Semen Strychni detoxicating method is following: Semen Strychni is soaked 50-90 minute in water after, under the 600-1200 degree, fry out white cigarette with Semen Strychni detoxification 4-8 time.
8. according to the said method for preparing of claim 7, it is characterized in that said Semen Strychni (processed) is that said Semen Strychni detoxicating method is following with Semen Strychni detoxification 6 times: Semen Strychni is soaked 60 minutes in water after, under 800 degree, fry out white cigarette.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103041061A (en) * | 2013-01-18 | 2013-04-17 | 崔苡菱 | Stasis-dissolving and pulse-invigorating powder |
| CN104288200A (en) * | 2014-10-09 | 2015-01-21 | 赵阳阳 | Medicine for treating cerebral thrombosis sequelae and preparation method thereof |
-
2012
- 2012-06-04 CN CN2012101796546A patent/CN102670718A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103041061A (en) * | 2013-01-18 | 2013-04-17 | 崔苡菱 | Stasis-dissolving and pulse-invigorating powder |
| CN103041061B (en) * | 2013-01-18 | 2015-01-07 | 崔苡菱 | Stasis-dissolving and pulse-invigorating powder |
| CN104288200A (en) * | 2014-10-09 | 2015-01-21 | 赵阳阳 | Medicine for treating cerebral thrombosis sequelae and preparation method thereof |
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Application publication date: 20120919 |