CN100998660B - Traditional Chinese medicine plaster for treating vertebral artery type cervical spondylosis and its preparing method - Google Patents
Traditional Chinese medicine plaster for treating vertebral artery type cervical spondylosis and its preparing method Download PDFInfo
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Abstract
A Chinese medicine in the form of paster for treating the arteria vertebralis type cervical spondylopathyl is prepared from 12 Chinese-medicinal materials including Chuan-xiong rhizome, notoginseng, cloves, red peony root, etc. Its preparing process is also disclosed.
Description
Technical field
The present invention relates to a kind of medicament for the treatment of cervical spondylosis, relate in particular to a kind of treatment vertebral artery type of cervical spondylosis Chinese medicine patch and preparation method thereof.
Background technology
Cervical spondylosis is a series of syndromes that cause muscle, ligament, nerve, spinal cord, vascular lesion to produce because of cervical region intervertebral disc, bone, joint and ligament degenerative change, it is the aseptic inflammation of musculi colli ligament and intervertebral disc, can stimulate the sympathetic nerve or the compressing vertebral artery of cervical region to cause the vertebral artery spasm, the vertebral artery blood flow is descended, vertebral artery type of cervical spondylosis promptly occurs.Vertebral artery type of cervical spondylosis is common, frequently-occurring disease, and the sickness rate of vertebral artery type is only second to spondylotic radiculopathy, and its seriousness is only second to myeloid form.Obvious ascendant trend is arranged in recent years, and the lighter influences quality of life and work efficiency, weight person's threat to life, be mainly in after the middle age, influence to mentality is more serious, but because the research of large sample report is rare, therefore domestic unified understanding and treatment as hypertension therapeutic instructed less.
The conventional measure of treatment vertebral artery type of cervical spondylosis have use that blood vessel dilating, arteriosclerosis, physical therapy, neck circumference are fixed, Hyperbaric oxygen chamber, traction, acupuncture, massage and operation etc., but its effect is all not good enough.Though have the Chinese medicine of various treatment cervical spondylosiss to occur simultaneously, its curative effect to vertebral artery type of cervical spondylosis is also not obvious.
Summary of the invention
Purpose of the present invention is exactly in order to solve the problem of present shortage treatment vertebral artery type of cervical spondylosis effective agent, and a kind of treatment vertebral artery type of cervical spondylosis Chinese medicine patch of advantages such as to have a prescription easy, and cost is lower, is easy to absorb, and curative effect is better is provided.
Advantages such as another object of the present invention is exactly for a kind of preparation method for the treatment of the vertebral artery type of cervical spondylosis Chinese medicine patch is provided, and it is easy that it has preparation, easy to use.
For achieving the above object, the present invention has adopted following technical scheme:
A kind of treatment vertebral artery type of cervical spondylosis Chinese medicine patch, it is grouped into by following one-tenth by weight,
Rhizoma Chuanxiong 8-10 part Radix Notoginseng 2-4 part Flos Caryophylli 2-4 part Radix Paeoniae Rubra 13-17 part Olibanum (processed) 8-10 part
Myrrha (processed) 8-10 part Radix Puerariae 18-21 part Ramulus Mori 11-13 part Fructus Liquidambaris 11-13 part nature ketone 5-7 part
The sub-2-4 part of Semen Momordicae Caulis Polygoni Multiflori 14-16 part.
Described each composition and weight portion proportioning thereof also can be as follows,
8 parts of 13 parts of Olibanum (processed)s of 2 parts of Radix Paeoniae Rubras of 2 portions of Flos Caryophyllis of 8 portions of Radix Notoginseng of Rhizoma Chuanxiong
5 parts of 11 parts of natural ketone of 11 parts of Fructus Liquidambaris of 18 parts of Ramulus Moris of 8 parts of Radix Puerariaes of Myrrha (processed)
14 parts of 2 parts of Caulis Polygoni Multiflori of Semen Momordicae.
Described each composition and weight portion proportioning thereof also can be as follows,
10 parts of 17 parts of Olibanum (processed)s of 4 parts of Radix Paeoniae Rubras of 4 portions of Flos Caryophyllis of 10 portions of Radix Notoginseng of Rhizoma Chuanxiong
7 parts of 13 parts of natural ketone of 13 parts of Fructus Liquidambaris of 21 parts of Ramulus Moris of 10 parts of Radix Puerariaes of Myrrha (processed)
16 parts of 4 parts of Caulis Polygoni Multiflori of Semen Momordicae.
Described each composition and weight portion proportioning thereof also can be as follows,
9 parts of 15 parts of Olibanum (processed)s of 3 parts of Radix Paeoniae Rubras of 3 portions of Flos Caryophyllis of 9 portions of Radix Notoginseng of Rhizoma Chuanxiong
6 parts of 12 parts of natural ketone of 12 parts of Fructus Liquidambaris of 20 parts of Ramulus Moris of 9 parts of Radix Puerariaes of Myrrha (processed)
15 parts of 3 parts of Caulis Polygoni Multiflori of Semen Momordicae.
A kind of preparation method for the treatment of the vertebral artery type of cervical spondylosis Chinese medicine patch the steps include:
(1) the general's sub-2-4 part of Rhizoma Chuanxiong 8-10 part Radix Notoginseng 2-4 part Flos Caryophylli 2-4 part Radix Paeoniae Rubra 13-17 part Olibanum (processed) 8-10 part Myrrha (processed) 8-10 part Radix Puerariae 18-21 part Ramulus Mori 11-13 part Fructus Liquidambaris 11-13 part nature ketone 5-7 part Semen Momordicae Caulis Polygoni Multiflori 14-16 part by weight grinds to form powder and crosses 200 mesh sieves;
(2) it is an amount of to get white vinegar;
(3) above-mentioned two kinds of materials are modulated into pasty state or pie gets final product.
The traditional Chinese medical science belongs to vertebral artery type of cervical spondylosis the category of " dizzy ", " arthromyodynia ".Pathogenic process often arthromyodynia formerly, with the passing of time the patient bends over the desk or excessively reaches medicated pillow discomfort etc. with the power of neck shoulder can make it to increase the weight of.And the cervical region damp that is affected by the cold makes local stagnation of QI-blood, head and neck pains and produce arthromyodynia, and long-term qi depression to blood stasis, clear YANG failing to ascend, wet impaction expectorant, multiple because of deficiency of both the liver and kidney, excessive rising of liver-YANG is disturbed on the priming wind-phlegm, so see dizzy, headache etc.
Etiology and pathogenesis at primary disease is that arthromyodynia formerly is the root of disease, so control with activating blood circulation to dissipate blood stasis, dredge the meridian passage is main.Rhizoma Chuanxiong in the prescription, Radix Notoginseng, Radix Paeoniae Rubra, Olibanum (processed) and Myrrha (processed) have the effect of promoting blood circulation to remove obstruction in the collateral, improve partial blood circulation, increase the vertebral artery blood flow.Modern medicine study thinks and Radix Puerariae, Fructus Chaenomelis, Caulis Polygoni Multiflori contains flavone, vitamin C respectively, and lecithin has antihistaminic, and the effect of cerebral blood flow increasing amount can obviously reduce capillary permeability, increases the drag of blood capillary.Therefore for the blood supply insufficiency of vertebral artery type of cervical spondylosis, significant improvement effect is arranged.
Chinese medicine external curing disease, it is the unique Therapeutic Method of a cover that tcm clinical practice treatment disease sums up for thousands of years, it is collection medicine, acupoint stimulation, meridians sensing, and the holographic biological theoretical effect for one that absorbs in conjunction with modern percutaneous is rapid, easy, inexpensive, safety, toxic and side effects is little and the efficient ways that can continue.The water content of keratodermatitis is the function of envionmental humidity, the Chinese medicine external application, a kind of sweat of " gas-tight storing and not eliminating " local formation is difficult to evaporate the air-tight state of diffusion, make the horny layer water content increase to 50% by 5%-15%, horny layer is through hydration, be expandable into porous state, be easy to medicine and penetrate.And there is test to show that fragrant medicine makes sebum film can improve 8%-10% to the transmitance of medicine.For further improving penetrating of medicine, make it to tell on, when using this Chinese medicine patch, also can on skin, smear certain dermal osmosis accelerator, as azone.Azone is 1-positive dodecyl aza cyclohepta alkane-2 ketone, is a kind of novel, highly effective skin penetration enhancer of safety non-toxic, is widely used in the pharmacy industry as medicines dressing.For strengthening the absorption of our effective ingredient, local skin coating azone can promote water solublity and fat-soluble medicine composition to arrive focus by skin.Because its Transdermal absorption effect has hysteresis, so should before medication it be applied to the position of preparing the drug of topical application, drug absorption can increase drug effect fully, cooperates oral flunarizine expansion of cerebral vascular simultaneously, improves brain blood circulation.Azone adds the external application of Chinese medicine and cooperates flunarizine oral medication vertebral artery type of cervical spondylosis effect obviously to be better than the oral person of simple flunarizine, and curative effect is reliable, and medication is convenient, few side effects is suitable at clinical application, not only can treat cervical spondylosis, also can treat cerebral infarction, senile dementia etc.
Clinical data shows: in 204 routine SPONDYLOPATHY OF VERTEBRAL ARTERY TYPE, and wherein male 106 examples, women 98 examples, age 26-78 year, average out to 47.3 years old.Inclusion criteria: the dizzy symptoms such as dizziness and tinnitus, dim eyesight of prolonged and repeated outbreak are arranged, companion or do not accompany the history of dampinging off, the incidence activity rotates to be main inducing.The film making of X line shows cervical vertebra uncovertebral joint hyperosteogeny, or stenosis of disc space, and the physiology curvature changes, the transcranial doppler prompting, and vertebra basilar artery average peak flow velocity, relaxing period later and decadent stage of a school of thought speed speed.Get rid of patients such as ear source property and eye vertigo, neurosis, drug intoxication and cerebrovascular accident, fracture of cervical vertebra, dislocation of cervical vertebra, tuberculosis of spine.204 examples are divided into treatment at random and organize 103 examples, with matched group 101 examples.
Therapeutic Method: treatment group, 3% azone is dissolved in 95% ethanol, get about 1ml, white vinegar is an amount of, with vinegar with Chinese herbal medicine powder (Rhizoma Chuanxiong, Radix Notoginseng, Flos Caryophylli, Radix Paeoniae Rubra, Olibanum (processed), Myrrha (processed), Radix Puerariae, Ramulus Mori, Fructus Liquidambaris, natural ketone, Semen Momordicae, Caulis Polygoni Multiflori) furnishing pasty state.Be applied on DAZHUI acupoint, the bilateral Jianjing point skin, blended rubber cloth covers fixing, and the drug of topical application was changed Chinese medicine after 24 hours, the next day once, logotype 25 days, oral flunarizine 5mg/ days simultaneously.Matched group: only oral flunarizine 5mg/ days, the preceding clothes of sleeping every night serve on 25 days.Observe treatment front and back symptom, the vertebral artery blood circumstance changes.
Used statistical method: measurement data meets normal distribution, represents with r ± s; Relatively use between group and design the t check in groups; Relatively use paired t-test before and after the treatment; Clinical efficacy is analyzed with Radit.
Symptom score and criterion of therapeutical effect: the weight according to cardinal symptom (headache, dizzy, nauseating, cervical pain) degree is divided into severe, moderate, slight, nothing.Corresponding score value was respectively 6,4,2,0 fens.Criterion of therapeutical effect: cure: transference cure, limb functional recover is normal, can normally work and work; Produce effects: transference cure, the more preceding improvement of TCD result, daily routines do not have obvious obstacle; Take a turn for the better: sx, limb function improves: invalid: symptom, limb function do not have obvious improvement.
Therapeutic outcome: treatment two groups of patient's symptom score in back and left and right vertebral artery (LVA, RVA) see table 1 for details with basilar artery (BA) TCD testing result.103 examples are organized in treatment, cure 63 examples, 61.2%; Produce effects 36 examples, 34.9%; 3 examples that take a turn for the better, 2.9%; Invalid 1 example, 1%; Total effective rate 96.1%.Matched group is 101 examples, cures 41 examples respectively, 40.6%; Produce effects 31 examples, 30.7%; 21 examples that take a turn for the better, 20.8%; Invalid 8 examples, 7.9%; Total effective rate 71.3%.Two groups are compared P＜0.05.
Symptom score and TCD testing result are relatively before and after the table 1 liang group patient treatment
Annotate: compare * p＜0.05 in organizing with before the treatment; #p＜0.05 is compared with matched group in the treatment back.
The treatment group is not all found other side effect for two groups except that because of the slight chafe of Chinese medicine.
The invention has the beneficial effects as follows: therapeutic effect, it is easy, easy to use to fill a prescription.
The specific embodiment
The invention will be further described below in conjunction with embodiment.
Embodiment 1:
By weight, each composition is:
8 parts of 8 parts of Myrrha (processed)s of 13 parts of Olibanum (processed)s of 2 parts of Radix Paeoniae Rubras of 2 portions of Flos Caryophyllis of 8 portions of Radix Notoginseng of Rhizoma Chuanxiong
14 parts of 2 parts of Caulis Polygoni Multiflori of 5 parts of Semen Momordicae of 11 parts of natural ketone of 11 parts of Fructus Liquidambaris of 18 parts of Ramulus Moris of Radix Puerariae.
Be ground into powder and cross 200 mesh sieves, be mixed into pasty state with an amount of white vinegar then and get final product.
Be dissolved in 95% ethanol with 3% azone earlier in use, get about 1ml, be coated with on trowel DAZHUI acupoint, the bilateral Jianjing point skin, blended rubber cloth covers to be fixed, and the drug of topical application was changed Chinese medicine after 24 hours, the next day once, logotype 25 days, oral flunarizine 5mg/ days while.
Embodiment 2:
By weight, each composition is:
10 parts of 10 parts of Myrrha (processed)s of 17 parts of Olibanum (processed)s of 4 parts of Radix Paeoniae Rubras of 4 portions of Flos Caryophyllis of 10 portions of Radix Notoginseng of Rhizoma Chuanxiong
16 parts of 4 parts of Caulis Polygoni Multiflori of 7 parts of Semen Momordicae of 13 parts of natural ketone of 13 parts of Fructus Liquidambaris of 21 parts of Ramulus Moris of Radix Puerariae.
Be ground into powder and cross 200 mesh sieves, be mixed into pie with an amount of white vinegar then and get final product.
All the other are identical with embodiment 1, repeat no more.
Embodiment 3:
By weight, each composition is:
9 parts of 9 parts of Myrrha (processed)s of 15 parts of Olibanum (processed)s of 3 parts of Radix Paeoniae Rubras of 3 portions of Flos Caryophyllis of 9 portions of Radix Notoginseng of Rhizoma Chuanxiong
15 parts of 3 parts of Caulis Polygoni Multiflori of 6 parts of Semen Momordicae of 12 parts of natural ketone of 12 parts of Fructus Liquidambaris of 20 parts of Ramulus Moris of Radix Puerariae.
All the other are identical with embodiment 1, repeat no more.
Claims (5)
1. treat the vertebral artery type of cervical spondylosis Chinese medicine patch for one kind, it is characterized in that: it is grouped into by the following one-tenth of weight portion meter,
Rhizoma Chuanxiong 8-10 part Radix Notoginseng 2-4 part Flos Caryophylli 2-4 part Radix Paeoniae Rubra 13-17 part Olibanum (processed) 8-10 part
Myrrha (processed) 8-10 part Radix Puerariae 18-21 part Ramulus Mori 11-13 part Fructus Liquidambaris 11-13 part nature ketone 5-7 part
The sub-2-4 part of Semen Momordicae Caulis Polygoni Multiflori 14-16 part.
2. treatment vertebral artery type of cervical spondylosis Chinese medicine patch according to claim 1 is characterized in that: described each composition and weight portion proportioning thereof are as follows,
8 parts of 13 parts of Olibanum (processed)s of 2 parts of Radix Paeoniae Rubras of 2 portions of Flos Caryophyllis of 8 portions of Radix Notoginseng of Rhizoma Chuanxiong
5 parts of 11 parts of natural ketone of 11 parts of Fructus Liquidambaris of 18 parts of Ramulus Moris of 8 parts of Radix Puerariaes of Myrrha (processed)
14 parts of 2 parts of Caulis Polygoni Multiflori of Semen Momordicae.
3. treatment vertebral artery type of cervical spondylosis Chinese medicine patch according to claim 1 is characterized in that: described each composition and weight portion proportioning thereof are as follows,
10 parts of 17 parts of Olibanum (processed)s of 4 parts of Radix Paeoniae Rubras of 4 portions of Flos Caryophyllis of 10 portions of Radix Notoginseng of Rhizoma Chuanxiong
7 parts of 13 parts of natural ketone of 13 parts of Fructus Liquidambaris of 21 parts of Ramulus Moris of 10 parts of Radix Puerariaes of Myrrha (processed)
16 parts of 4 parts of Caulis Polygoni Multiflori of Semen Momordicae.
4. treatment vertebral artery type of cervical spondylosis Chinese medicine patch according to claim 1 is characterized in that: described each composition and weight portion proportioning thereof are as follows,
9 parts of 15 parts of Olibanum (processed)s of 3 parts of Radix Paeoniae Rubras of 3 portions of Flos Caryophyllis of 9 portions of Radix Notoginseng of Rhizoma Chuanxiong
6 parts of 12 parts of natural ketone of 12 parts of Fructus Liquidambaris of 20 parts of Ramulus Moris of 9 parts of Radix Puerariaes of Myrrha (processed)
15 parts of 3 parts of Caulis Polygoni Multiflori of Semen Momordicae.
5. preparation method for the treatment of the vertebral artery type of cervical spondylosis Chinese medicine patch is characterized in that: its step is,
(1) general's Rhizoma Chuanxiong 8-10 part Radix Notoginseng 2-4 part Flos Caryophylli 2-4 part Radix Paeoniae Rubra 13-17 part Olibanum (processed) by weight
8-10 part Myrrha (processed) 8-10 part Radix Puerariae 18-21 part Ramulus Mori 11-13 part Fructus Liquidambaris 11-13 part nature ketone 5-7 part wood
Small pin for the case 2-4 part Caulis Polygoni Multiflori 14-16 part grinds to form powder and crosses 200 mesh sieves;
(2) it is an amount of to get white vinegar;
(3) above-mentioned two kinds of materials are modulated into pasty state or pie gets final product.
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| CN101862431B (en) * | 2009-04-20 | 2011-11-23 | 赵宗仙 | Chinese medicinal composition for treating vertebral arterial type of cervicalspondylosis by Chinese medicament fumigation |
| CN104306592A (en) * | 2014-09-28 | 2015-01-28 | 苏州市天灵中药饮片有限公司 | Plaster for treating cervical spondylosis and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1451421A (en) * | 2002-04-12 | 2003-10-29 | 解其珍 | Chinese medicine plaster for treating ostealgia |
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| CN1451421A (en) * | 2002-04-12 | 2003-10-29 | 解其珍 | Chinese medicine plaster for treating ostealgia |
Non-Patent Citations (2)
| Title |
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| 徐方菊.中药外敷治疗颈椎病98例.中国民间疗法 12 2.2004,12(2),23. * |
| 徐方菊.中药外敷治疗颈椎病98例.中国民间疗法12 2.2004,12(2),23. |
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