CN109646512A - A kind of external medicine composition for promoting chronic wound to heal - Google Patents
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- A61K36/185—Magnoliopsida (dicotyledons)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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Abstract
The present invention provides a kind of Chinese medicine compositions for promoting chronic wound to heal, it is prepared by the bulk pharmaceutical chemicals of following weight proportion: 40~60 parts of Cortex Phellodendri, 40~60 parts of caulis lonicerae, 24~36 parts of Radix Astragali, 16~24 parts of Rhizoma Atractylodis Macrocephalae, 8~12 parts of Radix Angelicae Sinensis.The traditional chinese medicine composition of the invention is clearing heat and detoxicating, nourishing qi and blood, restrains myogenic；Cure mainly the long disunion of the surface of a wound caused by deficient vital QI leading to lingering of pathogen；There is remarkable result for treatment chronic wound.
Description
Technical field
The present invention relates to the field of Chinese medicines, and in particular to a kind of external application Chinese medicine group for promoting chronic wound to heal
Close object.
Background technique
Chronic wound is commonly called as ulcer, also referred to as chronic wounds or chronic wound.Currently, international wound healing association
Definition and description for chronic wound, which there is no, uniformly to be defined, and is generally understood are as follows: under the action of various internal and external factors, Wu Fatong
Cross it is normal orderly and repair process reaches dissection and functionally good working condition in time, and then enter a kind of pathological inflammatory and react
The surface of a wound of state.For macroscopic view, the formation of chronic wound mainly due to angiogenesis is insufficient, innervation it is impaired with
And cell migration obstacle etc. causes, including venous ulcer, ischemic ulcer, pressure ulcer, metabolic ulcer and infectivity
Ulcer etc.；On microcosmic, the reparation of chronic wound is inflammatory cell, repair cell, extracellular matrix and cell factor etc.
Multifactor common participation and hight coordinate, the complex process mutually regulated and controled: after one side immunocyte abnormal activation, a large amount of inflammatories
The release such as the factor, proteolytic enzyme and reactive oxygen species, excessive inflammatory response form epidermis and granulation can not, on the other hand, wound
Because hypoxic-ischemic, collagen synthesis are reduced, the proliferation of fibroblast, epidermal cell etc. and migration are limited in face, lead to the surface of a wound
Circuitous prolong is not cured.
Although chronic wound will not life-threatening immediately, up to the several months even the several years, ten several years it is prolonged
It is not cured, seriously affects the rehabilitation of patient's protopathy and quality of life, heavy nursing and financial burden are also brought to family.Long-term wound
Face disunion easily causes the destruction of sclerotin, and a small number of surface of a wound more not may even happen that canceration；Meanwhile if infection diffusion occurs,
It can lead to the complication such as pyemia, not only aggravate protopathy, and patient vitals will be jeopardized.Route dressing change technology is often for slow
Property refractory wounds curative effect is not good enough, although wet union technology improves the healing rate of the surface of a wound to a certain extent, price
Expensive modern dressing brings heavier financial burden to family and society, and the microcirculation because surface of a wound part can not be changed,
Micro-ecological environment and may cause treatment failure.Therefore, a kind of chronic refractory for the treatment of promotion safely, effectively, inexpensive is needed
The drug of wound healing.
Summary of the invention
The purpose of the present invention is to provide a kind of external medicine compositions for promoting chronic wound to heal.
The present invention provides a kind of Chinese medicine compositions for promoting chronic wound to heal, it is by following weight
The bulk pharmaceutical chemicals of proportion are prepared: 40~60 parts of Cortex Phellodendri, 40~60 parts of caulis lonicerae, and 24~36 parts of Radix Astragali, 16~24 parts of Rhizoma Atractylodis Macrocephalae, when
Return 8~12 parts.
Further, aforementioned Chinese medicine composition is prepared by the bulk pharmaceutical chemicals of following weight proportion: 50 parts of Cortex Phellodendri, honeysuckle
50 parts of rattan, 30 parts of Radix Astragali, 20 parts of Rhizoma Atractylodis Macrocephalae, 10 parts of Radix Angelicae Sinensis.
Further, aforementioned Chinese medicine composition is that by the medicinal powder of bulk pharmaceutical chemicals of the weight proportion, the water of bulk pharmaceutical chemicals or have
Solvent extract is active constituent, in addition the preparation that pharmaceutically acceptable auxiliary material is prepared.
Further, the preparation is external preparation.
Further, the external preparation is spray, lotion, Wet-dressing agent.
The present invention also provides a kind of methods for preparing aforementioned Chinese medicine composition, it includes the following steps:
A, the raw material of each weight proportion is weighed；
B, raw material directly beaten to powder, or after adding water or organic solvent to extract, pharmaceutically acceptable auxiliary material or auxiliary is added
Property ingredient is prepared.
Further, in the step b, be extracted as adding water to cook raw material 3 times, merging filtrate to get.
Further, described to add water to cook raw material 3 times are as follows: the water of the 1st addition raw material 4~5 times (v/w), immersion 20~
After 40min, 20~40min, filtering are decocted；The water of 2nd addition raw material 3~4 times (v/w) decocts 10~30min, filtering；The
The water of 3 additions raw material 2~3 times (v/w) decocts 5~20min, filtering.
The present invention also provides purposes of the aforementioned Chinese medicine composition in the drug for preparing wound healing.
Further, the surface of a wound is chronic wound.
" v/w " refers to mL/g in the present invention.
Chinese medicine composition of the invention is made of Cortex Phellodendri, caulis lonicerae, Radix Astragali, Rhizoma Atractylodis Macrocephalae and Radix Angelicae Sinensis traditional Chinese medicine of the five flavours.
Cortex Phellodendri heat-clearing and damp-drying drug, purging intense heat, except steaming, detoxification sore treatment in side, caulis lonicerae is clearing heat and detoxicating, dispelling wind dredging collateral, and the two reuse is
Monarch drug in a prescription, the benefits of playing eliminating dampness heat-clearing, apocenosis removing toxic substances of analgesia altogether, is with remaining heresy of dispelling, Radix Astragali invigorating qi for strengthening superficies, pus draining and toxin expelling, myogenic, Rhizoma Atractylodis Macrocephalae invigorating the spleen benefit
Gas, eliminating dampness are altogether ministerial drug, share with Cortex Phellodendri, caulis lonicerae and developed simultaneously with strengthening vital QI to eliminate pathogenic factors with Radix Astragali phase 5, and can mitigate Cortex Phellodendri, honeysuckle
The cold disadvantage to prevent wound just of rattan.The surface of a wound with the passing of time must gas consumption blood trouble, therefore with Chinese Angelica blood replonishing promoting blood circulation be adjutant with unimpeded blood vessels.It takes a broad view of
Quan Fang, heat-clearing and damp-drying drug, QI invigorating removing toxic substances, blood circulation promoting and enriching, perverse trend must drive, just be so incensed that help, qi and blood circulation, then the surface of a wound with the passing of time not more obtains
With healing.
The traditional chinese medicine composition of the invention is clearing heat and detoxicating, nourishing qi and blood, restrains myogenic；The surface of a wound caused by deficient vital QI leading to lingering of pathogen is cured mainly not to be cured long
It closes；There is remarkable result for treatment chronic wound.
Obviously, above content according to the present invention, according to the ordinary technical knowledge and customary means of relevant art,
Under the premise of not departing from above-mentioned basic fundamental thought of the invention, the modification, replacement or change of other diversified forms can also be made.
The specific embodiment of form by the following examples remakes further specifically above content of the invention
It is bright.But the range that this should not be interpreted as to the above-mentioned theme of the present invention is only limitted to example below.It is all to be based on above content of the present invention
The technology realized all belongs to the scope of the present invention.
Detailed description of the invention
Fig. 1 is that calcaneal osteomyelitis companion chronic ulcer patient uses wound healing process after the traditional chinese medicine composition of the invention.
Fig. 2 is that tophus companion infective wound surface patient uses wound healing process after the traditional chinese medicine composition of the invention.
Fig. 3 is that the postoperative chronic infective surface of a wound patient of chronic osteomyelitis uses wound healing after the traditional chinese medicine composition of the invention
Journey.
Specific embodiment
The preparation of 1 the traditional chinese medicine composition of the invention of embodiment
1, bulk pharmaceutical chemicals: Cortex Phellodendri 50g, caulis lonicerae 50g, Radix Astragali 30g, Rhizoma Atractylodis Macrocephalae 20g, Radix Angelicae Sinensis 10g.
2, each bulk pharmaceutical chemicals preparation method: are weighed by above-mentioned weight proportion；3 doses of bulk pharmaceutical chemicals are taken to be packed into disposable non-woven gauze,
Medicinal material is sufficiently impregnated 30 minutes using the drinking water 700mL for meeting state health standards；Using boiling machine (the former doctor of Beijing east China
Treat the production of equipment Co., Ltd, model: YJD13-GL) it is cooked by slow fire after intense fire is boiled, it is decocted altogether under normal pressure 30 minutes,
Filtrate is left and taken after double filtration and sterilizing；Drinking water 600mL is added again, secondary decoction takes filtrate after twenty minutes；Third time adds
Enter 400mL drinking water, decocts 15 minutes, merge all filtrates, there are filtrate 900mL, using traditional Chinese herbal decoction packing machine (Bei Jingdong
Hua Yuan Medical Equipment Co., Ltd. produces, model: YB50-250) filtrate is packed into 100mL vacuum packaging bag.
The preparation of 2 the traditional chinese medicine composition of the invention of embodiment
1, bulk pharmaceutical chemicals: Cortex Phellodendri 40g, caulis lonicerae 60g, Radix Astragali 24g, Rhizoma Atractylodis Macrocephalae 16g, Radix Angelicae Sinensis 12g.
2, each bulk pharmaceutical chemicals preparation method: are weighed by above-mentioned weight proportion；3 doses of bulk pharmaceutical chemicals are taken to be packed into disposable non-woven gauze,
Medicinal material is sufficiently impregnated 20 minutes using the drinking water 700mL for meeting state health standards；Using boiling machine (the former doctor of Beijing east China
Treat the production of equipment Co., Ltd, model: YJD13-GL) it is cooked by slow fire after intense fire is boiled, it is decocted altogether under normal pressure 40 minutes,
Filtrate is left and taken after double filtration and sterilizing；Drinking water 600mL is added again, secondary decoction took filtrate after 30 minutes；Third time adds
Enter 400mL drinking water, decocts 20 minutes, merge all filtrates, there are filtrate 900mL, using traditional Chinese herbal decoction packing machine (Bei Jingdong
Hua Yuan Medical Equipment Co., Ltd. produces, model: YB50-250) filtrate is packed into 100mL vacuum packaging bag.
The preparation of 3 the traditional chinese medicine composition of the invention of embodiment
1, bulk pharmaceutical chemicals: Cortex Phellodendri 60g, caulis lonicerae 40g, Radix Astragali 36g, Rhizoma Atractylodis Macrocephalae 24g, Radix Angelicae Sinensis 8g.
2, each bulk pharmaceutical chemicals preparation method: are weighed by above-mentioned weight proportion；3 doses of bulk pharmaceutical chemicals are taken to be packed into disposable non-woven gauze,
Medicinal material is sufficiently impregnated 40 minutes using the drinking water 700mL for meeting state health standards；Using boiling machine (the former doctor of Beijing east China
Treat the production of equipment Co., Ltd, model: YJD13-GL) it is cooked by slow fire after intense fire is boiled, it is decocted altogether under normal pressure 30 minutes,
Filtrate is left and taken after double filtration and sterilizing；Drinking water 600mL is added again, secondary decoction took filtrate after 15 minutes；Third time adds
Enter 400mL drinking water, decocts 15 minutes, merge all filtrates, there are filtrate 900mL, using traditional Chinese herbal decoction packing machine (Bei Jingdong
Hua Yuan Medical Equipment Co., Ltd. produces, model: YB50-250) filtrate is packed into 100mL vacuum packaging bag.
Beneficial effects of the present invention are proved below by way of specific clinical test.
The clinical efficacy of 1 the traditional chinese medicine composition of the invention of test example
1, clinical case
Observation case totally 55, age are 46.74 ± 15.31 years old average.
1.1 are included in standard
With chronic osteomyelitis, infective wound surface, diabetes with infection, tophus with infection, rheumatism immune system disease
Disease merges chronic wound caused by surface of a wound etc., and surface of a wound area >=1cm2< 50cm simultaneously2Person.
1.2 exclusion criteria
Standard person is included in 1. not meeting；
2. the surface of a wound not more is with skin canceration for a long time, or merges serious general infection, tumour, tuberculosis and serious primary
Property disease, psychosis person；
3. having severely subnormal reactor to drug used in scheme and participating in other researchers；
4. meet the standard of being included in, but to the compliance of doctor's advice difference or cannot follow-up person on schedule so that can not judge curative effect
Or data does not carry out therapeutic evaluation person completely without method.
2, treatment method
Using iodophor disinfection surface of a wound surrounding skin, the surface of a wound with dressing tweezers gently wipes the surface of a wound after wiping using physiological saline
The necrotic tissue on surface, the Chinese medicine composition prepared after washing away necrotic tissue with physiological saline using the embodiment of the present invention 1 are slow
After rinsing the surface of a wound (making medical fluid in superficial residence a little time as far as possible), covered with sterile gauze；It is daily to rinse 1 time, each dosage
Depending on surface of a wound size, washing lotion is made to rinse the entire surface of a wound, it is 10mL~20mL that general diameter, which is less than 5cm surface of a wound dosage, is greater than 5cm
Surface of a wound dosage is 20mL~100mL, and the surface of a wound dosage more than secretion can take the circumstances into consideration to increase, and it is poor to create all skin conditions, as ischemic necrosis,
Pi Yuan is pale, eczema, pigmentation etc., and Chinese medicine composition prepared by the present invention can be used and be soaked in soak on sterile gauze.
3, curative effect judging standard
The criterion of therapeutical effect in " tcm clinical practice Illnesses Diagnoses criterion of therapeutical effect " promulgated referring to State Administration of Traditional Chinese Medicine, and tie
Clinic is closed to be evaluated:
Recovery from illness: surface of a wound epithelium is completely covered, and scar is solid, without the false healing phenomenon such as subcutaneous empyema；
Effective: surface of a wound area reduces the scope > 75%, and granulation tissue is fresh and alive, no purulent secretion；
Improve: surface of a wound area reduces the scope >=25%, and nothing or a small amount of purulent secretion have red granulation tissue；
Invalid: surface of a wound area reduces the scope < 25%, still there is purulent secretion, with dark-coloured granulation tissue.
4, treatment results
(1) surface of a wound Bacteria Culture negative conversion rate
1 wound secretion Bacteria Culture is carried out to wounds respectively before test and after treatment 7d, 10d, 14d, 21d,
Bacteria Culture negative conversion rate is calculated, formula is bacterium negative conversion rate=(bacterium before number of cases/medication that surface of a wound Bacteria Culture is turned out cloudy after medication
Culture is positive number of cases) × 100%.Share before 47 Wound treatings that there are bacterium infections, after treatment 7 days, 26 bacteriums turn
Yin, negative conversion rate 55.32%, after treatment 10 days, total 38 bacteriums are turned out cloudy, negative conversion rate 80.85%, after treatment 14 days, altogether
It counts 41 bacteriums to turn out cloudy, negative conversion rate 87.23%, after treatment 21 days, total 43 bacteriums are turned out cloudy, negative conversion rate 91.49%.
Test result explanation, the traditional chinese medicine composition of the invention have good inhibiting effect for surface of a wound bacterium.
(2) curative effect
After having carried out dressing in 21 days by a definite date to 55 chronic wounds using the traditional chinese medicine composition of the invention, curative effect
As shown in table 1.Effective percentage is the sum of cure rate, obvious effective rate and improvement rate.
Efficacy result [n (%)] after the treatment of 1 the traditional chinese medicine composition of the invention of table
| Total case | Recovery from illness | It is effective | It improves | In vain |
| 55 | 9 (16.37%) | 45 (81.81%) | 1 (1.81%) | 0 (0%) |
As seen from the experiment: the effective percentage of the traditional chinese medicine composition of the invention is up to 100%.
(3) wound healing time
After 21 days, continue to have carried out dressing to 46 surface of a wound not healed, until wound healing, finally, all surface of a wound
Healed, the average healing (29.98 ± 8.07) day.
Test result explanation, the traditional chinese medicine composition of the invention have remarkable result for treatment chronic wound.
5, typical case
1 calcaneal osteomyelitis of typical case is with chronic ulcer
Gender: female；Age: 79 years old；Underlying diseases: 3 grades of high blood pressure, high danger, Hypoproteinemia；Main suit: it takes
In out after fixed debridement, through modern dressing dressing less effective；Prove that there is pseudomonas aeruginosa in wound after Bacteria Culture.
Treatment is rinsed using Chinese medicine composition prepared by embodiment 1 to patient, daily to rinse simultaneously soak 1 time, each dosage
For 20mL.Patient was rinsed since on October 12nd, 2018 to November 27, as shown in Figure 1, it can be seen that wounds epithelium
It is completely covered, scar is solid, without the false healing phenomenon such as subcutaneous empyema.
2 tophus of typical case is with infective wound surface
Gender: male；Age 75 years old；Underlying diseases: 3 grades of high blood pressure, high danger, gout, kidney function is abnormal, oldness
Pulmonary tuberculosis；Main suit: discovery gout 20+, the right foot Metatarsophalangeal joint tophus ulceration 1+ month；Wound is proved after Bacteria Culture
There is staphylococcus aureus.
The Chinese medicine composition prepared to patient using embodiment 1 rinses treatment, daily to rinse 1 time, and each dosage is 20~
40mL.Patient was rinsed since on November 7th, 2018 to December 18, as shown in Figure 2, it can be seen that wounds epithelium is complete
Covering, scar is solid, without the false healing phenomenon such as subcutaneous empyema.
The postoperative chronic infective surface of a wound of 3 chronic osteomyelitis of typical case
Gender: male；Age: 49 years old；Underlying diseases: left tibia chronic osteomyelitis；Main suit: left leg infection focus is slow
Property ulcer remove postoperative 1 year, with the sepage 1+ month；Prove that there is Pseudomonas aeruginosa in wound after Bacteria Culture.
Treatment is rinsed using Chinese medicine composition prepared by embodiment 1 to patient, daily to rinse 1 time, each dosage is 20mL.
Patient was rinsed since on September 27th, 2018 to October 30, as shown in Figure 3, it can be seen that and wounds epithelium is completely covered,
Scar is solid, without the false healing phenomenon such as subcutaneous empyema.
To sum up, the traditional chinese medicine composition of the invention is clearing heat and detoxicating, nourishing qi and blood, restrains myogenic；Cure mainly the surface of a wound caused by deficient vital QI leading to lingering of pathogen
Long disunion；There is remarkable result for treatment chronic wound.
Claims (10)
1. a kind of Chinese medicine composition for promoting chronic wound to heal, it is characterised in that: it is matched by following weight
The bulk pharmaceutical chemicals of ratio are prepared: 40~60 parts of Cortex Phellodendri, 40~60 parts of caulis lonicerae, and 24~36 parts of Radix Astragali, 16~24 parts of Rhizoma Atractylodis Macrocephalae, Radix Angelicae Sinensis
8~12 parts.
2. Chinese medicine composition according to claim 1, it is characterised in that: it is prepared by the bulk pharmaceutical chemicals of following weight proportion
It forms: 50 parts of Cortex Phellodendri, 50 parts of caulis lonicerae, 30 parts of Radix Astragali, 20 parts of Rhizoma Atractylodis Macrocephalae, 10 parts of Radix Angelicae Sinensis.
3. Chinese medicine composition according to claim 1 or 2, it is characterised in that: it is by the bulk pharmaceutical chemicals of the weight proportion
Medicinal powder, bulk pharmaceutical chemicals water or extractive with organic solvent be active constituent, in addition what pharmaceutically acceptable auxiliary material was prepared
Preparation.
4. Chinese medicine composition according to claim 3, it is characterised in that: the preparation is external preparation.
5. Chinese medicine composition according to claim 4, it is characterised in that: the external preparation is spray, lotion, soak
Agent.
6. a kind of method for preparing Chinese medicine composition described in Claims 1 to 5 any one, it is characterised in that: it includes as follows
Step:
A, the raw material of each weight proportion is weighed；
B, raw material directly beaten to powder, or after adding water or organic solvent to extract, be added pharmaceutically acceptable auxiliary material or it is complementary at
Divide and is prepared.
7. according to the method described in claim 6, it is characterized by: being extracted as adding water to cook raw material 3 times in the step b, conjunction
And filtrate to get.
8. according to the method described in claim 7, it is characterized by: described add water to cook raw material 3 times are as follows: the 1st addition raw material 4
The water of~5 times (v/w) after impregnating 20~40min, decocts 20~40min, filtering；3~4 times of raw material (v/w) is added 2nd time
Water decocts 10~30min, filtering；The water of 3rd addition raw material 2~3 times (v/w) decocts 5~20min, filtering.
9. purposes of the Chinese medicine composition described in Claims 1 to 5 any one in the drug for preparing wound healing.
10. purposes according to claim 9, it is characterised in that: the surface of a wound is chronic wound.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114886967A (en) * | 2022-06-06 | 2022-08-12 | 潘星宇 | External traditional Chinese medicine composition for promoting tissue regeneration and preparation method thereof |
-
2019
- 2019-01-21 CN CN201910054700.1A patent/CN109646512B/en active Active
Non-Patent Citations (3)
| Title |
|---|
| 梅喜庆等: "双黄液辅助治疗促进糖尿病足溃疡愈合的临床疗效观察", 《中华中医药杂志》 * |
| 赵进喜等: "《糖尿病临床药对新用》", 31 December 2006, 中国医药科技出版社 * |
| 郭国华: "《临床中药辞典》", 30 April 2007, 湖南科学技术出版社 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114886967A (en) * | 2022-06-06 | 2022-08-12 | 潘星宇 | External traditional Chinese medicine composition for promoting tissue regeneration and preparation method thereof |
| CN114886967B (en) * | 2022-06-06 | 2024-02-06 | 潘星宇 | Externally-applied traditional Chinese medicine composition for promoting tissue regeneration and preparation method thereof |
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| CN109646512B (en) | 2021-07-30 |
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