CN105535508A - Radix astragali and sanguis draxonis bedsore healing unguent and preparation method - Google Patents
Radix astragali and sanguis draxonis bedsore healing unguent and preparation method Download PDFInfo
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/35—Extraction with lipophilic solvents, e.g. Hexane or petrol ether
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Abstract
The invention discloses radix astragali and sanguis draxonis bedsore healing unguent. The unguent is characterized by being prepared from, by weight, 56-66 parts of raw radix astragali, 56-66 parts of radix angelicae sinensis, 18-22 parts of radix arnebiae, 9-11 parts of rhizoma bletillae, 10.8-13.2 parts of sanguis draxonis, 13.5-16.5 parts of radix angelicae dahurica, 56-66 parts of white wax and 450-550 parts of sesame oil. The unguent is externally applied for treating bedsore, the cure rate can be raised, and furthermore, the disease course can be shortened.
Description
Technical field
The invention belongs to technical field of Chinese medicines, be specifically related to a kind of stilbene and exhaust more wound cream and preparation method.
Background technology
Along with modern society people dietary structure and living-pattern preservation, the diseases such as cardiovascular and cerebrovascular disease, diabetes, senile dementia increase year by year.These diseases develop into the later stage, and patient Duo Yin inconvenient activity stands the misery of long-term bed, and the nursing of family members is improper is easy to the formation causing decubital ulcer, and more, very painful, severe patient even can cause infection threat to life to touching difficulty.Account for 4.3% of inpatient at the sickness rate of U.S.'s decubital ulcer, its annual medical expense is up to 1,000,000,000 dollars, and Britain spends 200,000,000 pounds to be used for the treatment of patients with bedsore every year, China there is no statistics in this respect at present, but because of populous, bed patient is numerous, decubital ulcer sickness rate is also very high.For the treatment of decubital ulcer, doctor trained in Western medicine many employings debridement, external growth factor for treating, expensive.On the other hand, current clinical conventional Chinese patent medicine, as band bed sore ointment etc., clinical efficacy also has much room for improvement.
Summary of the invention
The object of the invention is to overcome above-mentioned technical problem and a kind of good effect be provided, have no side effect, shorten healing time, economic cheap stilbene exhausts and more creates cream.
Another object of the present invention is to provide above-mentioned stilbene to exhaust the preparation method of more wound cream.
A kind of stilbene exhausts more creates cream, comprises following component by weight: Radix Astragali 56-66 weight portion, Radix Angelicae Sinensis 56-66 weight portion, Radix Arnebiae (Radix Lithospermi) 18-22 weight portion, Pseudobulbus Bletillae (Rhizoma Bletillae) 9-11 weight portion, Sanguis Draxonis 10.8-13.2 weight portion, Radix Angelicae Dahuricae 13.5-16.5 weight portion, white beeswax 56-66 weight portion, Oleum Sesami 450-550 weight portion.
Above-mentioned stilbene exhausts the preparation method of more wound cream, comprises the following steps:
(1) get Radix Astragali, Radix Angelicae Sinensis, Radix Arnebiae (Radix Lithospermi), Radix Angelicae Dahuricae four Chinese medicine to enter in Oleum Sesami leaching 72 hours, then slow fire is tortured to micro-withered yellow, and silk filtering, removes slag, and after filter, Oleum Sesami is for subsequent use.
(2) step 1 is filtered rear Oleum Sesami to enter in pot to decoct and roll, lower Sanguis Draxonis, the Pseudobulbus Bletillaeization play white beeswax to the greatest extent afterwards, treat that white beeswax dissolves again, and stir the light cream being chilled to certain toughness and lubrication sense, quantitative separating, to obtain final product.
For achieving the above object, the present invention adopts following technical scheme:
Beneficial effect: this prescription external application for curing decubital ulcer, can not only improve cure rate, can also shorten the course of disease.
Function cures mainly: benefiting vital QI and blood, blood circulation promoting and blood stasis dispelling, reducing swelling and alleviating pain, expelling pus and promoting granulation, for the treatment of various decubital ulcer.
Fang Xie:
The traditional Chinese medical science thinks that decubital ulcer is exactly usually occur in deficiency of qi and blood, or the patient of the large wound of QI and blood.We know excessive rest on bed impairing QI, the deficiency of vital energy is then difficult hemopoietic, with the passing of time then QI and blood deficiency, muscles without support, easily send out decubital ulcer.Formed for decubital ulcer equally, and the unable eliminating the toxic material out by tonification of body, interior heresy must not be dispelled, then occur not high not red flat collapse unrestrained person this for vigour empty.
Analysis on TCM prescriptions: the Radix Astragali is sweet, tepor.Return spleen, lung meridian.Effect tonifying Qi and lifting yang, benefit defends consolidating superficial resistance, inducing diuresis to remove edema, holder skin ulcer granulation promoting." herbal classic ": " main carbuncle loses skin ulcer for a long time, evacuation of pus pain relieving ", " pearl sac ": " the sweet Wen Chunyang of the Radix Astragali, it is with having five: ... evacuation of pus pain relieving, hemopoietic of invigorating blood circulation, expelling the toxic substance from the body with tonic carbuncle of yin nature, be persons particularly liable to develop skin infection's panacea, five also ".Radix Angelicae Sinensis is sweet, pungent, warm.Return liver, the heart, spleen channel.Effect, for enriching blood, is invigorated blood circulation, regulating menstruation, pain relieving, intestine moistening.Radix Angelicae Sinensis can promoting blood circulation and detumescence pain relieving, again can tonic blood and growing muscle, " medicine class on the analogy of natural things ": " can and blood enrich blood ... primary symptom addiction, broken stagnant blood, removes all skin infection, treatment incised wound stagnant blood, and warming middle-JIAO moisturizes pain relieving "." book on Chinese herbal medicine is taken advantage of refined " is said: " skin infection, namely gas is not returned and taken the photograph, and Radix Angelicae Sinensis helps the use of gas, the body of beneficial blood, and QI and blood pathogen can be made respectively to be attributed to the ground of institute's Radix Angelicae Sinensis." Radix Arnebiae (Radix Lithospermi) is sweet, cold, GUIXIN, Liver Channel.Removing heat from blood and promoting blood circulation, the poison separating heat in blood is contained.For ulcer sores, burn due to hot liquid or fire etc." not Lu ": " waterway treats swelling completely pain.To close cream, treat children's's skin ulcer and face Zha ".Pseudobulbus Bletillae (Rhizoma Bletillae) is bitter, sweet, puckery, cold, returns lung, stomach, Liver Channel.Effect astringing to arrest bleeding, detumescence and promoting granulation." herbal classic ": " main carbuncle, malignant boil, lose cellulitis, the dead flesh of impairment of YIN, pathogen in stomach ", " book on Chinese herbal medicine converge speech ": " Pseudobulbus Bletillae (Rhizoma Bletillae), astringing QI, ooze expectorant, hemostasis, eliminating carbuncle medicine also ".Sanguis Draxonis sweet in the mouth, salty, property is put down, GUIXIN, Liver Channel.Change addiction pain relieving, hemostasis, promoting tissue regeneration and ulcer healing.Essentials of Matea Medica: " red complexion enters blood system, reinforcing the heart bag deficiency of liver-blood, special dehematize carbuncle, loose addiction tissue regeneration promoting, for blood panacea.Control interior blood trouble to gather, incised wound folding falls, ulcerous nonunion, pain relieving granulation promoting.Impatient, can not make to draw pus more." Radix Angelicae Dahuricae is pungent, warm, attach to the lung and stomach meridians.Effect is induced sweat loose wind, sensible, pain relieving, dampness leukorrhagia stopping, detumescence and apocenosis.Can be used for sore swollen toxin.White beeswax granulation promoting, hemostasis, analgesic therapy double as excipient.Oleum Sesami is refrigerant, removing toxic substances, skin moistening, also make excipient.
Detailed description of the invention
Below, in conjunction with example, substantive distinguishing features of the present invention and advantage are further described, but the present invention is not limited to listed embodiment.
Embodiment
A kind of stilbene exhausts more creates cream, comprises following component by weight: Radix Astragali 56 weight portion, Radix Angelicae Sinensis 56 weight portion, Radix Arnebiae (Radix Lithospermi) 18 weight portion, the Pseudobulbus Bletillae (Rhizoma Bletillae) 9 weight portion, Sanguis Draxonis 10.8 weight portion, the Radix Angelicae Dahuricae 13.5 weight portion, white beeswax 56 weight portion, Oleum Sesami 450 weight portion.
Above-mentioned stilbene exhausts the preparation method of more wound cream, comprises the following steps:
(1) get Radix Astragali, Radix Angelicae Sinensis, Radix Arnebiae (Radix Lithospermi), Radix Angelicae Dahuricae four Chinese medicine to enter in Oleum Sesami leaching 72 hours, then slow fire is tortured to micro-withered yellow, and silk filtering, removes slag, and after filter, Oleum Sesami is for subsequent use.
(2) step 1 is filtered rear Oleum Sesami to enter in pot to decoct and roll, lower Sanguis Draxonis, the Pseudobulbus Bletillaeization play white beeswax to the greatest extent afterwards, treat that white beeswax dissolves again, and stir the light cream being chilled to certain toughness and lubrication sense, quantitative separating, to obtain final product.
Usage and dosage: external, gets and spreads out in right amount on sterile gauze, and thickness is even, is greater than wound surface 1cm, spreads on affected part.Once a day.
Points for attention: person is forbidden following situations: 1. to certain the component allergy sufferers in this product or this product; 2. deep infection person is merged; 3. the angiopathy persons such as arterial occlusion are had.
Embodiment 2
A kind of stilbene exhausts more creates cream, comprises following component by weight: Radix Astragali 66 weight portion, Radix Angelicae Sinensis 66 weight portion, Radix Arnebiae (Radix Lithospermi) 22 weight portion, the Pseudobulbus Bletillae (Rhizoma Bletillae) 11 weight portion, Sanguis Draxonis 13.2 weight portion, the Radix Angelicae Dahuricae 16.5 weight portion, white beeswax 66 weight portion, Oleum Sesami 550 weight portion.
Above-mentioned stilbene exhausts the preparation method of more wound cream, comprises the following steps:
(1) get Radix Astragali, Radix Angelicae Sinensis, Radix Arnebiae (Radix Lithospermi), Radix Angelicae Dahuricae four Chinese medicine to enter in Oleum Sesami leaching 72 hours, then slow fire is tortured to micro-withered yellow, and silk filtering, removes slag, and after filter, Oleum Sesami is for subsequent use.
(2) step 1 is filtered rear Oleum Sesami to enter in pot to decoct and roll, lower Sanguis Draxonis, the Pseudobulbus Bletillaeization play white beeswax to the greatest extent afterwards, treat that white beeswax dissolves again, and stir the light cream being chilled to certain toughness and lubrication sense, quantitative separating, to obtain final product.
Usage and dosage: external, gets and spreads out in right amount on sterile gauze, and thickness is even, is greater than wound surface 1cm, spreads on affected part.Once a day.
Points for attention: person is forbidden following situations: 1. to certain the component allergy sufferers in this product or this product; 2. deep infection person is merged; 3. the angiopathy persons such as arterial occlusion are had.
Clinical data:
Patients with bedsore totally 50 examples that case selected by this problem is my institute's department of Chinese medicine outpatient service in year February in October, 2008 to 2010 and is in hospital, decubital ulcer 76 place; Man 24 example, female 26 example; 60 ± 2.1 years old mean age; Wherein I type decubital ulcer 28 place, comprises sacrococcygeal region 13 place, heel portion 9 place, patella ulnaris joint portion 6 place; II type decubital ulcer 36 place, comprises sacrococcygeal region 16 place, heel portion 12 place, patella ulnaris joint 8 place; III type decubital ulcer 12 place, comprises sacrococcygeal region 6 place, heel portion 3 place, patella ulnaris joint 3 place.
The 76 decubital ulcer affected parts, place that will observe are divided into treatment group and matched group two groups at random, and concrete grouping situation is as follows:
| Group | Number of cases | I type decubital ulcer | II type decubital ulcer | III type decubital ulcer |
| Treatment group | 38 | 12 | 20 | 8 |
| Matched group | 38 | 16 | 16 | 4 |
Treatment group: adopt routine disinfection decubital ulcer surrounding skin to I type patients with bedsore, after wound surface is clean with normal saline flushing, stilbene is exhausted Yuchuang oinment for treating sore and evenly spread on wound surface, thickness is about about 0.2cm, covers outward, change dressings every day 1 time with aseptic oil gauze and aseptic Dry Dressing.
To II, III type patients with bedsore, then slough is wiped out in first thoroughly debridement, gradation, after clean with 3% hydrogen peroxide and normal saline flushing, treat that wound surface dries up, cream of getting it filled evenly spreads on wound surface, its thickness is about about 0.5cm (ointment is too thin, and moisture easily runs off and affects the lasting of drug effect), cover with aseptic oil gauze and aseptic Dry Dressing, fix, how many every days changes dressings 1 ~ 2 time depending on wound secretion; To cavernous wound, after clean with 3% hydrogen peroxide and normal saline flushing, aseptic ointment ribbon gauze applied ointment, clogs in wound, make wound surface contact ointment completely as far as possible, cover with aseptic dressing, fixing, l ~ 2 time of changing dressings every day.
Matched group: adopt routine disinfection decubital ulcer surrounding skin to I type patients with bedsore, after wound surface is clean with normal saline flushing, gives cover with the kpetrolatum gauze of skin ulcer face homalographic and cover with aseptic Dry Dressing, changes dressings every day 1 time.
To II, III type patients with bedsore, then slough is wiped out in first thoroughly debridement, gradation, after clean with 3% hydrogen peroxide and normal saline flushing, give to cover with the kpetrolatum gauze of skin ulcer face homalographic and cover with aseptic Dry Dressing, fixing, how many every days changes dressings 1 ~ 2 time depending on wound secretion.
Two groups of cases are all strictly nursed by nursing care of decubitus ulcer routine, and duty is stood up, and within every 2 hours when the state of an illness is permitted, stand up 1 time.
2.2 curative effect determinate standard
Cure: wound surface heals completely, the red and swollen congestion of I type decubital ulcer disappears completely.Effective: wound surface or red and swollen congestion reduce more than 80%, without exudate than before treatment.Effective: wound surface or red and swollen congestion reduce more than 30%, and exudate is a little.Invalid: area reduce be less than 30% or wound surface color and luster gloomy, around grow without granulation tissue, or red and swollen congestion does not disappear.
2.3 results of statistical analysis (adopting software SPSS to data analysis)
| Group | Number of cases | Cure | Effective | Effectively | Invalid | Effective percentage |
| Medication group | 38 | 18 | 9 | 11 | 3 | 92.11% |
| Matched group | 38 | 14 | 7 | 9 | 8 | 78.95% |
Note: medication group is compared with matched group and draws P < 0.05.
Treatment time contrast table (
± s)
| Group | I type decubital ulcer administration time (d) | II, III type decubital ulcer administration time (d) |
| Medication group | =7±3.58 | =14±5.11 |
| Matched group | =7±4.25 | =17±5.83 |
I type decubital ulcer medication group and matched group P > 0.05 on administration time; II, III type decubital ulcer medication group and matched group P < 0.05 on administration time.
2.4 clinical observation result analyses
In this experiment, the total effective rate of medication group and matched group is respectively 92.11% and 78.95%, and respectively statistical analysis is carried out to the effective and invalid number of cases of two groups, draw P < 0.05, there is statistical significance, illustrate that stilbene exhausts Yuchuang oinment for treating sore external application for curing decubital ulcer effect and is better than applying merely routine of western medicine external application for curing.And respectively statistical analysis is carried out to I type and II, III type decubital ulcer healing time, draw P<0.05, illustrate two groups of medicinal applications in different times decubital ulcer healing drug effect be differentiated.And the average healing of medication group is smaller than matched group, absolutely proves that stilbene exhausts Yuchuang oinment for treating sore and treating the evident in efficacy of ulceration-type decubital ulcer, simple western medicine external application is better than to the successful of wound surface convergence healing.
The above is only the preferred embodiment of the present invention; it should be pointed out that for those skilled in the art, under the premise without departing from the principles of the invention; can also make some improvements and modifications, these improvements and modifications also should be considered as protection scope of the present invention.
Claims (2)
1. a stilbene exhausts and more creates cream, it is characterized in that, comprise following component by weight: Radix Astragali 56-66 weight portion, Radix Angelicae Sinensis 56-66 weight portion, Radix Arnebiae (Radix Lithospermi) 18-22 weight portion, Pseudobulbus Bletillae (Rhizoma Bletillae) 9-11 weight portion, Sanguis Draxonis 10.8-13.2 weight portion, Radix Angelicae Dahuricae 13.5-16.5 weight portion, white beeswax 56-66 weight portion, Oleum Sesami 450-550 weight portion.
2. stilbene described in claim 1 exhausts a preparation method for more wound cream, it is characterized in that, comprises the following steps:
(1) get Radix Astragali, Radix Angelicae Sinensis, Radix Arnebiae (Radix Lithospermi), Radix Angelicae Dahuricae four Chinese medicine to enter in Oleum Sesami leaching 72 hours, then slow fire is tortured to micro-withered yellow, and silk filtering, removes slag, and after filter, Oleum Sesami is for subsequent use;
(2) step 1 is filtered rear Oleum Sesami to enter in pot to decoct and roll, lower Sanguis Draxonis, the Pseudobulbus Bletillaeization play white beeswax to the greatest extent afterwards, treat that white beeswax dissolves again, and stir the light cream being chilled to certain toughness and lubrication sense, quantitative separating, to obtain final product.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109674945A (en) * | 2019-03-05 | 2019-04-26 | 南充市中医医院 | The Chinese medicine composition and preparation method thereof of ulcer is cured in a kind of myogenic hemostasia and detumescence analgesic |
| CN113230332A (en) * | 2021-05-29 | 2021-08-10 | 黄淑珂 | Medicine for treating wound ulceration of diabetic patient and non-healing wound, preparation and preparation method thereof |
| CN113425797A (en) * | 2021-07-02 | 2021-09-24 | 昆明市第二人民医院 | Medicine and dressing for healing skin wound and preparation method thereof |
-
2016
- 2016-01-28 CN CN201610056096.2A patent/CN105535508A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109674945A (en) * | 2019-03-05 | 2019-04-26 | 南充市中医医院 | The Chinese medicine composition and preparation method thereof of ulcer is cured in a kind of myogenic hemostasia and detumescence analgesic |
| CN113230332A (en) * | 2021-05-29 | 2021-08-10 | 黄淑珂 | Medicine for treating wound ulceration of diabetic patient and non-healing wound, preparation and preparation method thereof |
| CN113230332B (en) * | 2021-05-29 | 2022-05-13 | 黄淑珂 | Medicine for treating wound ulceration of diabetic patient and non-healing wound, preparation and preparation method thereof |
| CN113425797A (en) * | 2021-07-02 | 2021-09-24 | 昆明市第二人民医院 | Medicine and dressing for healing skin wound and preparation method thereof |
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Application publication date: 20160504 |