CN109646512B - A topical Chinese medicinal composition for promoting healing of chronic intractable wound - Google Patents
A topical Chinese medicinal composition for promoting healing of chronic intractable wound Download PDFInfo
- Publication number
- CN109646512B CN109646512B CN201910054700.1A CN201910054700A CN109646512B CN 109646512 B CN109646512 B CN 109646512B CN 201910054700 A CN201910054700 A CN 201910054700A CN 109646512 B CN109646512 B CN 109646512B
- Authority
- CN
- China
- Prior art keywords
- parts
- raw materials
- wound
- chronic
- traditional chinese
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 37
- 230000001684 chronic effect Effects 0.000 title claims abstract description 33
- 230000035876 healing Effects 0.000 title claims abstract description 19
- 230000001737 promoting effect Effects 0.000 title claims abstract description 14
- 230000000699 topical effect Effects 0.000 title description 2
- 239000003814 drug Substances 0.000 claims abstract description 47
- 239000002994 raw material Substances 0.000 claims abstract description 34
- 241000205585 Aquilegia canadensis Species 0.000 claims abstract description 11
- 229940079593 drug Drugs 0.000 claims abstract description 11
- 241000132012 Atractylodes Species 0.000 claims abstract description 9
- 235000001287 Guettarda speciosa Nutrition 0.000 claims abstract description 9
- 239000008280 blood Substances 0.000 claims abstract description 9
- 210000004369 blood Anatomy 0.000 claims abstract description 9
- 241000972672 Phellodendron Species 0.000 claims abstract description 8
- 235000006533 astragalus Nutrition 0.000 claims abstract description 7
- 239000000463 material Substances 0.000 claims abstract description 5
- 244000061520 Angelica archangelica Species 0.000 claims abstract 2
- 206010052428 Wound Diseases 0.000 claims description 78
- 208000027418 Wounds and injury Diseases 0.000 claims description 78
- 239000000706 filtrate Substances 0.000 claims description 17
- 238000002360 preparation method Methods 0.000 claims description 14
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 14
- 238000001914 filtration Methods 0.000 claims description 9
- 238000000034 method Methods 0.000 claims description 7
- 241001061264 Astragalus Species 0.000 claims description 5
- 210000004233 talus Anatomy 0.000 claims description 5
- 238000005303 weighing Methods 0.000 claims description 5
- 238000001035 drying Methods 0.000 claims description 4
- 239000003960 organic solvent Substances 0.000 claims description 4
- 230000029663 wound healing Effects 0.000 claims description 4
- 239000002671 adjuvant Substances 0.000 claims description 3
- 230000003213 activating effect Effects 0.000 claims description 2
- 239000004480 active ingredient Substances 0.000 claims description 2
- 239000003795 chemical substances by application Substances 0.000 claims description 2
- 238000000605 extraction Methods 0.000 claims description 2
- 239000006210 lotion Substances 0.000 claims description 2
- 239000000843 powder Substances 0.000 claims description 2
- 238000010298 pulverizing process Methods 0.000 claims description 2
- 238000002791 soaking Methods 0.000 claims description 2
- 239000007921 spray Substances 0.000 claims description 2
- 230000001988 toxicity Effects 0.000 claims 1
- 231100000419 toxicity Toxicity 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 18
- 230000001717 pathogenic effect Effects 0.000 abstract description 6
- 238000005469 granulation Methods 0.000 abstract description 5
- 230000003179 granulation Effects 0.000 abstract description 5
- 244000052769 pathogen Species 0.000 abstract description 4
- 230000007812 deficiency Effects 0.000 abstract description 3
- 231100000331 toxic Toxicity 0.000 abstract description 3
- 230000002588 toxic effect Effects 0.000 abstract description 3
- 241000045403 Astragalus propinquus Species 0.000 abstract description 2
- 239000003651 drinking water Substances 0.000 description 9
- 235000020188 drinking water Nutrition 0.000 description 9
- 208000015181 infectious disease Diseases 0.000 description 9
- 241000125175 Angelica Species 0.000 description 7
- 241000894006 Bacteria Species 0.000 description 7
- 230000001580 bacterial effect Effects 0.000 description 7
- 208000025865 Ulcer Diseases 0.000 description 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 6
- 238000004806 packaging method and process Methods 0.000 description 6
- 231100000397 ulcer Toxicity 0.000 description 6
- 238000005406 washing Methods 0.000 description 6
- 201000010099 disease Diseases 0.000 description 5
- 230000028327 secretion Effects 0.000 description 5
- 238000012360 testing method Methods 0.000 description 5
- 206010031256 Osteomyelitis chronic Diseases 0.000 description 4
- 238000006243 chemical reaction Methods 0.000 description 4
- 210000000981 epithelium Anatomy 0.000 description 4
- 230000002458 infectious effect Effects 0.000 description 4
- 230000002829 reductive effect Effects 0.000 description 4
- 231100000241 scar Toxicity 0.000 description 4
- 210000003491 skin Anatomy 0.000 description 4
- 238000007920 subcutaneous administration Methods 0.000 description 4
- 230000001225 therapeutic effect Effects 0.000 description 4
- 208000032544 Cicatrix Diseases 0.000 description 3
- 206010063560 Excessive granulation tissue Diseases 0.000 description 3
- 241000972673 Phellodendron amurense Species 0.000 description 3
- 206010061926 Purulence Diseases 0.000 description 3
- 229940107666 astragalus root Drugs 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 210000001126 granulation tissue Anatomy 0.000 description 3
- 230000006872 improvement Effects 0.000 description 3
- 238000002156 mixing Methods 0.000 description 3
- 230000008439 repair process Effects 0.000 description 3
- 230000037387 scars Effects 0.000 description 3
- 230000001954 sterilising effect Effects 0.000 description 3
- 239000003053 toxin Substances 0.000 description 3
- 231100000765 toxin Toxicity 0.000 description 3
- 238000009461 vacuum packaging Methods 0.000 description 3
- 201000005569 Gout Diseases 0.000 description 2
- 206010020772 Hypertension Diseases 0.000 description 2
- 206010061218 Inflammation Diseases 0.000 description 2
- 206010031252 Osteomyelitis Diseases 0.000 description 2
- 241000589517 Pseudomonas aeruginosa Species 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 238000001647 drug administration Methods 0.000 description 2
- 230000003203 everyday effect Effects 0.000 description 2
- 230000004054 inflammatory process Effects 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 230000007774 longterm Effects 0.000 description 2
- 230000001338 necrotic effect Effects 0.000 description 2
- 239000002504 physiological saline solution Substances 0.000 description 2
- 208000037920 primary disease Diseases 0.000 description 2
- 238000011084 recovery Methods 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- 229940126680 traditional chinese medicines Drugs 0.000 description 2
- 201000008827 tuberculosis Diseases 0.000 description 2
- 208000035143 Bacterial infection Diseases 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- 102000004127 Cytokines Human genes 0.000 description 1
- 108090000695 Cytokines Proteins 0.000 description 1
- 241000721047 Danaus plexippus Species 0.000 description 1
- 206010011985 Decubitus ulcer Diseases 0.000 description 1
- 201000004624 Dermatitis Diseases 0.000 description 1
- 206010060803 Diabetic foot infection Diseases 0.000 description 1
- 102000010834 Extracellular Matrix Proteins Human genes 0.000 description 1
- 108010037362 Extracellular Matrix Proteins Proteins 0.000 description 1
- 208000034767 Hypoproteinaemia Diseases 0.000 description 1
- 206010021143 Hypoxia Diseases 0.000 description 1
- 208000035901 Ischaemic ulcer Diseases 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 102000035195 Peptidases Human genes 0.000 description 1
- 108091005804 Peptidases Proteins 0.000 description 1
- 208000004210 Pressure Ulcer Diseases 0.000 description 1
- 206010040047 Sepsis Diseases 0.000 description 1
- 241000191967 Staphylococcus aureus Species 0.000 description 1
- 206010066901 Treatment failure Diseases 0.000 description 1
- 208000000558 Varicose Ulcer Diseases 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 230000007495 abnormal renal function Effects 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000033115 angiogenesis Effects 0.000 description 1
- 208000010668 atopic eczema Diseases 0.000 description 1
- 208000022362 bacterial infectious disease Diseases 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 230000012292 cell migration Effects 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 238000001804 debridement Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 210000001339 epidermal cell Anatomy 0.000 description 1
- 210000002615 epidermis Anatomy 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 230000007717 exclusion Effects 0.000 description 1
- 210000002744 extracellular matrix Anatomy 0.000 description 1
- 210000002950 fibroblast Anatomy 0.000 description 1
- 238000011010 flushing procedure Methods 0.000 description 1
- 210000002683 foot Anatomy 0.000 description 1
- 230000007954 hypoxia Effects 0.000 description 1
- 210000002865 immune cell Anatomy 0.000 description 1
- 208000026278 immune system disease Diseases 0.000 description 1
- 210000004969 inflammatory cell Anatomy 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 230000030214 innervation Effects 0.000 description 1
- 208000028867 ischemia Diseases 0.000 description 1
- 230000000302 ischemic effect Effects 0.000 description 1
- 210000001699 lower leg Anatomy 0.000 description 1
- 230000003340 mental effect Effects 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 210000000878 metatarsophalangeal joint Anatomy 0.000 description 1
- 230000004089 microcirculation Effects 0.000 description 1
- 230000005012 migration Effects 0.000 description 1
- 238000013508 migration Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000017074 necrotic cell death Effects 0.000 description 1
- 230000000474 nursing effect Effects 0.000 description 1
- 150000002926 oxygen Chemical class 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 230000019612 pigmentation Effects 0.000 description 1
- 230000002980 postoperative effect Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 229940024999 proteolytic enzymes for treatment of wounds and ulcers Drugs 0.000 description 1
- 238000010926 purge Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 210000002303 tibia Anatomy 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/756—Phellodendron, e.g. corktree
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/284—Atractylodes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Dermatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention provides a traditional Chinese medicine composition for promoting healing of chronic refractory wound surfaces, which is prepared from the following raw material medicines in parts by weight: 40-60 parts of phellodendron, 40-60 parts of honeysuckle stem, 24-36 parts of astragalus membranaceus, 16-24 parts of bighead atractylodes rhizome and 8-12 parts of angelica. The Chinese medicinal composition has the effects of clearing away heat and toxic materials, tonifying qi and nourishing blood, and astringing and promoting granulation; mainly treats the chronic nonunion of the wound surface caused by lingering pathogen due to deficiency of vital qi; has obvious effect on treating chronic intractable wound.
Description
Technical Field
The invention relates to the field of traditional Chinese medicines, and in particular relates to an external traditional Chinese medicine composition for promoting healing of chronic intractable wounds.
Background
Chronic intractable wound surface is commonly called ulcer, also called chronic wound or chronic wound surface. Currently, the international wound healing society has no uniform definition for the definition and description of chronic wounds, and generally understands that: under the action of various internal and external factors, the wound surface in a pathological inflammatory reaction state can not be reached in an anatomical and functional complete state through a normal and orderly timely repair process. Macroscopically, the formation of chronic refractory wounds is mainly caused by insufficient angiogenesis, damaged innervation, cell migration disorder and the like, and comprises venous ulcer, ischemic ulcer, pressure ulcer, metabolic ulcer, infectious ulcer and the like; microscopically, the repair of chronic intractable wound surfaces is a complex process in which multiple factors such as inflammatory cells, repair cells, extracellular matrix and cytokines participate together, and are highly coordinated and mutually regulated: on one hand, after immune cells are abnormally activated, a large number of inflammatory factors, proteolytic enzymes, active oxygen clusters and the like are released, excessive inflammatory reaction causes the formation of epidermis and granulation to be impossible, and on the other hand, wound surfaces are subjected to ischemia and hypoxia, collagen synthesis is reduced, proliferation and migration of fibroblasts, epidermal cells and the like are limited, and wound surfaces are not healed.
Although the chronic refractory wound surface does not immediately threaten life, the chronic refractory wound surface can not be healed for a long time of months, even years or decades, thus seriously affecting the original disease recovery and life quality of patients and also bringing heavy nursing and economic burden to families. The bone is easy to damage due to long-term wound nonunion, and few wounds are not more and even possibly cancerate; meanwhile, if infection spreads, complications such as sepsis and the like can be caused, so that not only can the primary disease be aggravated, but also the life of a patient can be endangered. The conventional dressing change technology is not good enough in curative effect on chronic difficult-to-heal wound surfaces, and the wet healing technology improves the healing rate of the wound surfaces to a certain extent, but the modern dressing with high price brings heavy economic burden to families and society, and treatment failure can be caused due to the fact that the microcirculation and the micro-ecological environment of the local wound surfaces cannot be changed. Therefore, a safe, effective and cheap medicament for promoting the healing of chronic refractory wounds is needed.
Disclosure of Invention
The invention aims to provide an external traditional Chinese medicine composition for promoting healing of chronic refractory wound surfaces.
The invention provides a traditional Chinese medicine composition for promoting healing of chronic refractory wound surfaces, which is prepared from the following raw material medicines in parts by weight: 40-60 parts of phellodendron, 40-60 parts of honeysuckle stem, 24-36 parts of astragalus membranaceus, 16-24 parts of bighead atractylodes rhizome and 8-12 parts of angelica.
Further, the traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 50 parts of phellodendron, 50 parts of honeysuckle stem, 30 parts of astragalus, 20 parts of bighead atractylodes rhizome and 10 parts of angelica.
Furthermore, the traditional Chinese medicine composition is a preparation prepared by taking the medicinal powder of the raw material medicines, the water or organic solvent extract of the raw material medicines as active ingredients and adding pharmaceutically acceptable auxiliary materials according to the weight ratio.
Further, the preparation is an external preparation.
Further, the external preparation is a spray, a lotion and a wet dressing agent.
The invention also provides a method for preparing the traditional Chinese medicine composition, which comprises the following steps:
a. weighing raw materials in each weight ratio;
b. pulverizing the raw materials directly, or extracting with water or organic solvent, and adding pharmaceutically acceptable adjuvants or auxiliary components.
Further, in the step b, the extraction is to decoct the raw materials with water for 3 times and to combine the filtrates, thus obtaining the traditional Chinese medicine.
Further, the decocting of the raw materials in water for 3 times is as follows: adding water 4-5 times (v/w) of the raw materials for the first time, soaking for 20-40 min, decocting for 20-40 min, and filtering; adding 3-4 times (v/w) of water into the raw materials for the 2 nd time, decocting for 10-30 min, and filtering; adding water 2-3 times (v/w) of the raw materials for the 3 rd time, decocting for 5-20 min, and filtering.
The invention also provides application of the traditional Chinese medicine composition in preparing a medicine for promoting wound healing.
Further, the wound is a chronic refractory wound.
In the present invention, "v/w" means mL/g.
The traditional Chinese medicine composition is prepared from five traditional Chinese medicines of phellodendron, honeysuckle stem, astragalus, bighead atractylodes rhizome and angelica.
In the formula, the phellodendron bark is used for clearing heat and drying dampness, purging fire and removing steam, detoxifying and treating sore, the honeysuckle stem is used for clearing heat and removing toxin, and is used as monarch drug for playing the effects of removing dampness and clearing heat, and expelling pus and removing toxin to eliminate residual pathogen, the astragalus root is used for tonifying qi and strengthening superficies, expelling toxin and expelling pus, and promoting granulation, the bighead atractylodes rhizome is used for tonifying spleen and replenishing qi and drying dampness, and is used as ministerial drug by being matched with the astragalus root and used together with the phellodendron bark and the honeysuckle stem to strengthen body resistance and eliminate pathogenic factors, and the cold property of the phellodendron bark and the honeysuckle stem can be alleviated to prevent the defect of damaging body resistance. The wound surface consumes qi and blood for a long time, so the blood-nourishing and blood-activating angelica is used as an adjuvant drug to smooth the blood vessels. By taking the whole formula into account, the wound surface which is not healed for a long time can be healed by clearing heat and drying dampness, tonifying qi and detoxifying, activating blood and replenishing blood, dispelling pathogenic qi, assisting vital qi and circulating qi and blood.
The Chinese medicinal composition has the effects of clearing away heat and toxic materials, tonifying qi and nourishing blood, and astringing and promoting granulation; mainly treats the chronic nonunion of the wound surface caused by lingering pathogen due to deficiency of vital qi; has obvious effect on treating chronic intractable wound.
Obviously, many modifications, substitutions, and variations are possible in light of the above teachings, without departing from the basic technical spirit of the present invention, as defined by the following claims.
The present invention will be described in further detail with reference to the following examples. This should not be understood as limiting the scope of the above-described subject matter of the present invention to the following examples. All the technologies realized based on the above contents of the present invention belong to the scope of the present invention.
Drawings
FIG. 1 shows the healing process of the wound of a patient with calcaneal osteomyelitis and chronic ulcer wound after the traditional Chinese medicine composition is used.
Fig. 2 shows the healing process of the wound of a patient with the tophus and infected wound surface after the traditional Chinese medicine composition is used.
FIG. 3 shows the healing process of chronic infectious wound after chronic osteomyelitis operation.
Detailed Description
EXAMPLE 1 preparation of the Chinese medicinal composition of the present invention
1. The raw material medicaments: 50g of phellodendron, 50g of honeysuckle stem, 30g of astragalus, 20g of bighead atractylodes rhizome and 10g of angelica.
2. The preparation method comprises the following steps: weighing the raw materials according to the weight ratio; 3 doses of the raw materials are taken and put into a disposable non-woven gauze, and the raw materials are fully soaked for 30 minutes by using 700mL of drinking water meeting the national sanitary standard; decocting with strong fire for 30min at normal pressure, and filtering and sterilizing to obtain filtrate; adding 600mL of drinking water again, decocting for 20 minutes twice, and taking the filtrate; adding 400mL of drinking water for the third time, decocting for 15 minutes, mixing all filtrates to obtain 900mL of filtrate, and packaging the filtrate into 100mL of vacuum packaging bag by using Chinese medicinal decoction packaging machine (type: YB50-250, manufactured by Beijing Tohua original medical equipment, Ltd.).
EXAMPLE 2 preparation of the Chinese medicinal composition of the present invention
1. The raw material medicaments: 40g of phellodendron, 60g of honeysuckle stem, 24g of astragalus, 16g of bighead atractylodes rhizome and 12g of angelica.
2. The preparation method comprises the following steps: weighing the raw materials according to the weight ratio; 3 doses of the raw materials are put into a disposable non-woven gauze, and the raw materials are fully soaked for 20 minutes by using 700mL of drinking water meeting the national sanitary standard; decocting with strong fire for 40min at normal pressure, and filtering and sterilizing to obtain filtrate; adding 600mL of drinking water again, decocting for 30 minutes twice, and taking the filtrate; adding 400mL of drinking water for the third time, decocting for 20 minutes, mixing all filtrates to obtain 900mL of filtrate, and packaging the filtrate into 100mL of vacuum packaging bag by using Chinese medicinal decoction packaging machine (type: YB50-250, manufactured by Beijing Tohua original medical equipment, Ltd.).
EXAMPLE 3 preparation of the Chinese medicinal composition of the present invention
1. The raw material medicaments: 60g of phellodendron, 40g of honeysuckle stem, 36g of astragalus root, 24g of bighead atractylodes rhizome and 8g of angelica.
2. The preparation method comprises the following steps: weighing the raw materials according to the weight ratio; 3 doses of the raw materials are put into a disposable non-woven gauze, and the raw materials are fully soaked for 40 minutes by using 700mL of drinking water meeting the national sanitary standard; decocting with strong fire for 30min at normal pressure, and filtering and sterilizing to obtain filtrate; adding 600mL of drinking water again, decocting for 15 minutes twice, and taking the filtrate; adding 400mL of drinking water for the third time, decocting for 15 minutes, mixing all filtrates to obtain 900mL of filtrate, and packaging the filtrate into 100mL of vacuum packaging bag by using Chinese medicinal decoction packaging machine (type: YB50-250, manufactured by Beijing Tohua original medical equipment, Ltd.).
The beneficial effects of the present invention are demonstrated by specific clinical trials below.
Test example 1 clinical efficacy of the Chinese medicinal composition of the present invention
1. Clinical cases
The observed cases were 55 cases in total, with an average age of 46.74 ± 15.31 years.
1.1 inclusion criteria
Chronic refractory wound surface caused by chronic osteomyelitis, infectious wound surface, diabetic foot infection, tophus infection, rheumatism immune system disease complicated wound surface, and wound surface area of not less than 1cm2At the same time less than 50cm2Thereby, the number of the parts can be reduced.
1.2 exclusion criteria
Those not meeting the inclusion standard;
② the long-term unhealed wound surface is accompanied with skin canceration, or serious general infection, tumor, tuberculosis, serious primary disease and mental system disease are combined;
third, the patients who have serious abnormal reaction to the medicine used in the scheme and are participating in other researchers;
those who meet the inclusion standard but have poor compliance with medical advice or cannot follow the diagnosis according to time, so that the patients cannot judge the curative effect or have incomplete data and cannot evaluate the curative effect.
2. Method of treatment
Using iodophor to disinfect skin around a wound surface, wiping the wound surface with physiological saline, then using forceps for changing the drug to gently scrape necrotic tissues on the surface of the wound surface, flushing the necrotic tissues with the physiological saline, then using the traditional Chinese medicine composition prepared in the embodiment 1 of the invention to slowly flush the wound surface (making the liquid medicine stay on the surface for a little time as much as possible), and then covering with sterile gauze; the traditional Chinese medicine composition is washed for 1 time every day, the dosage of each time depends on the size of the wound surface, the washing liquid is used for washing the whole wound surface, the diameter of the wound surface is usually less than 5cm, the dosage of the wound surface is 10-20 mL, the dosage of the wound surface is more than 5cm, the dosage of the wound surface is 20-100 mL, the dosage of the wound surface with more secretion can be increased appropriately, the skin condition around the wound is poor, such as ischemic necrosis, skin paleness, eczema, pigmentation and the like, and the traditional Chinese medicine composition prepared by the invention can be soaked on sterile gauze for wet dressing.
3. Criteria for judging therapeutic effects
According to the curative effect standard in the 'standard for diagnosing the curative effect of the clinical symptoms of the traditional Chinese medicine' issued by the State administration of traditional Chinese medicine, the evaluation is carried out by combining the clinic:
and (3) healing: the epithelium of the wound surface is completely covered, the scar is solid, and the false healing phenomena such as subcutaneous pus accumulation and the like do not exist;
the effect is shown: the wound surface area is reduced by more than 75 percent, the granulation tissue is fresh and alive, and purulent secretion does not exist;
improvement: the wound surface area reduction range is more than or equal to 25 percent, no or a small amount of purulent secretion exists, and red granulation tissues exist;
and (4) invalidation: the wound area is reduced by less than 25%, and purulent secretion is still present, accompanied by dark granulation tissue.
4. Therapeutic results
(1) Negative conversion rate of wound surface bacteria culture
The wound surface of the patient was subjected to bacterial culture of wound surface secretion 1 time before the test and after the treatment of 7d, 10d, 14d and 21d, respectively, and the bacterial culture to negative conversion rate was calculated as the bacterial negative conversion rate (number of cases of wound surface bacterial culture to negative after the drug administration/number of cases of bacterial culture to positive before the drug administration) × 100%. The bacterial infection exists in 47 cases of wounds before treatment, after 7 days of treatment, 26 cases of bacteria turn negative, the negative turning rate is 55.32%, after 10 days of treatment, 38 cases of bacteria turn negative, the negative turning rate is 80.85%, after 14 days of treatment, 41 cases of bacteria turn negative, the negative turning rate is 87.23%, and after 21 days of treatment, 43 cases of bacteria turn negative, and the negative turning rate is 91.49%.
The test result shows that the traditional Chinese medicine composition has good inhibition effect on wound bacteria.
(2) Therapeutic effect
The curative effect of the traditional Chinese medicine composition is shown in table 1 after the traditional Chinese medicine composition is used for changing 55 chronic intractable wound surfaces for 21 days. The effective rate is the sum of cure rate, significant efficiency and improvement rate.
TABLE 1 therapeutic results of the Chinese medicinal composition of the present invention after treatment [ n (%) ]
| General case | Recovery method | Show effect | Improvement of life | Invalidation |
| 55 | 9(16.37％) | 45(81.81％) | 1(1.81％) | 0(0％) |
From the test results, it can be seen that: the effective rate of the traditional Chinese medicine composition can reach 100%.
(3) Time of wound healing
After 21 days, dressing changes were continued on 46 unhealed wounds until the wounds healed, and finally, all wounds healed, with the average healing time (29.98 ± 8.07) days.
The test result shows that the traditional Chinese medicine composition has a remarkable effect on treating chronic refractory wound surfaces.
5. Typical cases
Typical case 1 calcaneal osteomyelitis with chronic ulcer wound surface
Sex of the patients: a woman; age: age 79; basic diseases: hypertension of grade 3, extremely high risk, hypoproteinemia; the main complaints are: after the internal fixation debridement is taken out, the dressing change effect is poor through modern dressing; after the bacterial culture, the wound is proved to have pseudomonas aeruginosa.
The patient is treated by rinsing with the traditional Chinese medicine composition prepared in example 1, and is rinsed and wet-compressed 1 time per day, and the dosage is 20 mL. The patients begin to wash from 10 and 12 days in 2018 to 11 and 27 days in 2018, as shown in fig. 1, the wound surface epithelium of the patients can be seen to be completely covered, the scars are firm, and the false healing phenomena such as subcutaneous purulence and the like do not exist.
Typical case 2 tophus accompanied with infection wound
Sex of the patients: male; age 75 years; basic diseases: hypertension of grade 3, extremely high risk, gout, abnormal renal function, old tuberculosis; the main complaints are: gout is found for 20+ years, and tophus of the first metatarsophalangeal joint of the right foot is broken for 1+ month; after the bacteria culture, the staphylococcus aureus is proved to be present at the wound.
The traditional Chinese medicine composition prepared in the embodiment 1 is used for washing treatment for a patient, and the washing is performed for 1 time every day, wherein the dosage is 20-40 mL each time. The patients begin to wash from 11 and 7 days in 2018 to 12 and 18 days in 18 months, as shown in fig. 2, the wound surface epithelium of the patients can be seen to be completely covered, the scars are firm, and the false healing phenomena such as subcutaneous purulence and the like do not exist.
Typical case 3 chronic osteomyelitis postoperative chronic infectious wound surface
Sex of the patients: male; age: age 49 years old; basic diseases: chronic osteomyelitis of the left tibia; the main complaints are: after one year of left shank infection focus chronic ulcer removal operation, the exudation is carried out for 1+ month; after the bacterial culture, the presence of pseudomonas aeruginosa at the wound is proved.
The traditional Chinese medicine composition prepared in example 1 is used for washing treatment for a patient, and washing is carried out 1 time per day, and the dosage is 20 mL. The patients begin to wash from 27 th 9 th 2018 to 30 th 10 th, as shown in fig. 3, the wound surface epithelium of the patients can be completely covered, the scars are firm, and the false healing phenomena such as subcutaneous purulence and the like do not exist.
In conclusion, the Chinese medicinal composition has the effects of clearing away heat and toxic materials, tonifying qi and nourishing blood, and astringing and promoting granulation; mainly treats the chronic nonunion of the wound surface caused by lingering pathogen due to deficiency of vital qi; has obvious effect on treating chronic intractable wound.
Claims (8)
1. A Chinese medicinal composition for promoting the healing of chronic intractable wounds by clearing heat and drying dampness, tonifying qi and removing toxicity, and activating blood and enriching blood is characterized in that: the external preparation is prepared from the following raw material medicines in parts by weight:
50 parts of phellodendron, 50 parts of honeysuckle stem, 30 parts of astragalus, 20 parts of bighead atractylodes rhizome and 10 parts of angelica.
2. The traditional Chinese medicine composition according to claim 1, characterized in that: the external preparation is prepared by taking the medicinal powder of the raw material medicines, the water or organic solvent extract of the raw material medicines as active ingredients and adding pharmaceutically acceptable auxiliary materials according to the weight ratio.
3. The traditional Chinese medicine composition according to claim 2, characterized in that: the external preparation is spray, lotion and wet dressing agent.
4. A method of preparing the Chinese medicinal composition of any one of claims 1 to 3, which comprises: it comprises the following steps:
a. weighing raw materials in each weight ratio;
b. pulverizing the raw materials directly, or extracting with water or organic solvent, and adding pharmaceutically acceptable adjuvants or auxiliary components.
5. The method of claim 4, wherein: in the step b, the extraction is to decoct the raw materials with water for 3 times and combine the filtrates to obtain the traditional Chinese medicine.
6. The method of claim 5, wherein: the raw materials decocted by adding water for 3 times are: adding water 4-5 times v/w of the raw materials for the first time, soaking for 20-40 min, decocting for 20-40 min, and filtering; adding 3-4 times v/w of water into the raw materials at the 2 nd time, decocting for 10-30 min, and filtering; and adding water 2-3 times v/w of the raw materials for 3 times, decocting for 5-20 min, and filtering.
7. Use of the Chinese medicinal composition of any one of claims 1 to 3 in the preparation of a medicament for promoting wound healing.
8. Use according to claim 7, characterized in that: the wound surface is chronic refractory wound surface.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2018116308129 | 2018-12-29 | ||
| CN201811630812 | 2018-12-29 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN109646512A CN109646512A (en) | 2019-04-19 |
| CN109646512B true CN109646512B (en) | 2021-07-30 |
Family
ID=66120655
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910054700.1A Active CN109646512B (en) | 2018-12-29 | 2019-01-21 | A topical Chinese medicinal composition for promoting healing of chronic intractable wound |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN109646512B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114886967B (en) * | 2022-06-06 | 2024-02-06 | 潘星宇 | Externally-applied traditional Chinese medicine composition for promoting tissue regeneration and preparation method thereof |
-
2019
- 2019-01-21 CN CN201910054700.1A patent/CN109646512B/en active Active
Non-Patent Citations (1)
| Title |
|---|
| 双黄液辅助治疗促进糖尿病足溃疡愈合的临床疗效观察;梅喜庆等;《中华中医药杂志》;20140930;第29卷(第9期);第3028-3030页，尤其是第3028页正文第1段，第3029页"2.药物配制"、"讨论" * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN109646512A (en) | 2019-04-19 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US11571452B2 (en) | Method of treating a skin wound with a liquid-state topical pharmaceutical composition | |
| CN102631423B (en) | Care solution for wound cleaning | |
| CN109646512B (en) | A topical Chinese medicinal composition for promoting healing of chronic intractable wound | |
| CN101693063A (en) | Chinese medicine preparation for treating burns and scalds and various refractory wounds | |
| CN112618646A (en) | Traditional Chinese medicine composition and traditional Chinese medicine oil for treating burns and preparation method thereof | |
| CN109602854B (en) | Ointment for treating burns and scalds and preparation method thereof | |
| CN106138569A (en) | A kind of Chinese medicine composition treating chronic wound and application thereof | |
| CN110624035A (en) | Ziqi tissue regeneration promoting paste | |
| CN114470056B (en) | A Chinese medicinal preparation for treating lower limb venous ulcer, and its preparation method and application method | |
| CN114886967A (en) | External traditional Chinese medicine composition for promoting tissue regeneration and preparation method thereof | |
| CN102698086B (en) | Chinese medicinal emulsion for treating bedsore accumulated toxin decay | |
| CN109674945A (en) | The Chinese medicine composition and preparation method thereof of ulcer is cured in a kind of myogenic hemostasia and detumescence analgesic | |
| CN102727698A (en) | Wound surface nursing powder for treating bedsore | |
| CN111544514A (en) | A Chinese medicinal ointment for treating burn and scald, and its preparation method | |
| CN101371880B (en) | Chinese medicinal composition for treating empyrosis wound surface | |
| CN1330365C (en) | Compound preparation its preparing method and use | |
| CN104784482A (en) | Traditional Chinese medicine for treating chronic pyogenic osteomyelitis | |
| CN104306734B (en) | Treat diabetic gangrene externally applied ointment preparation and preparation method thereof | |
| CN105832909A (en) | Traditional Chinese medicine preparation for treating necrotic ulcer of skin | |
| CN103127274A (en) | All-season burn and scald medicine for seasons | |
| CN108992581A (en) | A kind of traditional Chinese medicinal ointment and preparation method thereof for treating skin lesion | |
| CN1236798C (en) | External medicine for treating bone tuberculosis | |
| CN105056037A (en) | Medicine for treating cellulitis | |
| CN105168510A (en) | Traditional Chinese medicinal preparation for treating trauma | |
| CN105106768A (en) | Traditional Chinese medicine for treating bedsore |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |