CN1330365C - Compound preparation its preparing method and use - Google Patents
Compound preparation its preparing method and use Download PDFInfo
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- CN1330365C CN1330365C CNB2003101174360A CN200310117436A CN1330365C CN 1330365 C CN1330365 C CN 1330365C CN B2003101174360 A CNB2003101174360 A CN B2003101174360A CN 200310117436 A CN200310117436 A CN 200310117436A CN 1330365 C CN1330365 C CN 1330365C
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Abstract
The present invention discloses a compound preparation for curing wound infection, burn and scald. According to portions by weight, the compound preparation is composed of 15 to 22 portions of beauty berry herb, 17 to 25 portions of turmeric, 15 to 25 portions of rhubarb, 16 to 20 portions of bletilla tubers, 12 to 30 portions of phellodendron bark, 15 to 30 portions of ampelopsis and 2 to 12 portions of cutch. The preparation of the compound preparation comprises the following two step: 1. the phellodendron bark, the cutch, the rhubarb and the turmeric are weighed and decocted in water for 2 hours; decoction liquid is combined and concentrated to a proper quantity; alcohol is added until the alcohol content of the decoction liquid is 50%; mixture is laid aside for 48 hours and filtered for removing impurities; the alcohol is recycled; the rest clear liquid is taken for standby; 2. the beauty berry herb, the bletilla tubers and the ampelopsis are decocted in water for two times with 2 hours every time; decoction liquid is combined and concentrated to a proper quantity; liquid obtained in step (1) for standby is added, uniformly stirred, added with purification water to 1000 portions, uniformly mixed, filtered and filled to obtain the compound preparation.
Description
Technical field:
The present invention relates to a kind of compound preparation, specifically relate to a kind of compound preparation that is used for the treatment of infective wound surface, burn and scald.The invention still further relates to the preparation method of this compound preparation.
Background technology
The genesis mechanism of infective wound surface is after pathogenic bacterium are invaded body, and the part acute inflammations such as hyperemia, interstitial edema, cell are rotten, necrosis can occur and change then that ulceration forms ulcer.The treatment of infective wound surface is a great problem of surgery, and modern medicine is with soaks such as ethacridine, nitrofural, eusol, gentamycin treatment infective wound surface, and with control infection or impel wound surface convergence to take a turn for the better, curative effect is not good enough.Though some protective agents, antibiotic, vitamin, Rare Elements Preparations are extensively used, rest on substantially and wait for the wound normal healing stage, impel the wound healing effect very limited.
Burn and scald is owing to heating power (flame, pyritous gas, liquid or solid), electric energy, chemical substance, lonizing radiation etc. act on a kind of damage that human body causes, is wartime and commonly encountered diseases at ordinary times.Though traumatogenic reason is not quite similar, the pathological change and the Therapeutic Principle that cause are similar.Modern medicine is to the reason of burn, pathological change, and the Therapeutic Principle aspect such as lapses to after more and all develops, and the Chinese medicine and western medicine that is used to the wound surface of burning at present is not hundreds of down, does not also have a kind of medicine to reach ideal level.
Summary of the invention:
One object of the present invention is the shortcoming at the prior art existence, provides a kind of at the compound formulation that has good result aspect treatment infective wound surface, the burn and scald.
Another object of the present invention is to provide the preparation method of this compound preparation.
A further object of the invention is this compound preparation is used for the treatment of infective wound surface, burn and scald.
For achieving the above object, the present invention has taked following technical scheme:
A kind of compound preparation, in weight portion, make by the material medicine of following umber:
Folium Callicarpae Formosanae 15～22 Rhizoma Curcumae Longaes 17～25 Radix Et Rhizoma Rhei 15～25 Pseudobulbus Bletillae (Rhizoma Bletillae)s 16～20
Cortex Phellodendri 12～30 Radix Ampelopsis 15～30 Catechu 2～12.
As a kind of improvement of technique scheme, in weight portion, compound preparation is made by the material medicine of following umber:
Folium Callicarpae Formosanae 18～20 Rhizoma Curcumae Longaes 17～20 Radix Et Rhizoma Rhei 18～22 Pseudobulbus Bletillae (Rhizoma Bletillae)s 18～20
Cortex Phellodendri 12～20 lianas 15～25 Catechu 2～8.
Most preferably a kind of as technique scheme, in weight portion, compound preparation is made by the material medicine of following umber:
Folium Callicarpae Formosanae 20 Rhizoma Curcumae Longaes 18 Radix Et Rhizoma Rhei 20 Pseudobulbus Bletillae (Rhizoma Bletillae)s 18
Cortex Phellodendri 18 Radix Ampelopsis 18 Catechu 6.
Prepare the method for above-mentioned compound preparation, form by following steps successively:
(1) in weight portion, take by weighing Cortex Phellodendri, Catechu, Radix Et Rhizoma Rhei and the Rhizoma Curcumae Longae of above-mentioned formula ratio, decoct with water 2 hours, collecting decoction is concentrated into 200～400 parts of solution; And adding ethanol to decocting liquid, to contain the alcohol amount be 50%; Left standstill 48 hours, and removed by filter impurity, reclaim ethanol, it is standby to get the residue clear liquid;
(2) in weight portion, the Folium Callicarpae Formosanae, the Pseudobulbus Bletillae (Rhizoma Bletillae) and the Radix Ampelopsis that take by weighing above-mentioned formula ratio decoct with water 2 times, and each 2 hours, merge decoction liquor, be concentrated into 200～400 parts of solution; Add the reserve liquid that obtains in (1) step, stir evenly, add purified water to 1000 part, mixing filters, and packing promptly obtains compound preparation of the present invention.
Compound preparation of the present invention is a dark-brown solution, allows a spot of precipitation.
The compound preparation that is obtained by said method all can be used for treating infective wound surface, burn and scald, and has good effect.
Compared with the prior art, the present invention has following beneficial effect:
Complex treatment infective wound surface 2 all cure rates of the present invention are 80%, total effective rate is 98%, apparently higher than ethacridine (44.5,80%), the healing natural law of recovery from illness infective wound surface, complex of the present invention is 8.12 ± 2.56 days, obviously faster than ethacridine (11.06 ± 2.61), in complex treatment 2 weeks of infective wound surface of the present invention, wound surface antibacterial culturing negative conversion rate is 90%; Show that complex of the present invention has following characteristics: 1, cure rate height; 2, wound healing is fast; 3, bacteriostasis is obvious; 4, have no side effect.A large amount of clinical datas show that soak wound surface of the present invention does not have the medication reaction, and to hemogram, the no abnormal variation of hepatic and renal function, the animal toxicology experiment also shows external safety non-toxic of the present invention.
The used Chinese and Western external used medicine of burn only considers that from infecting, restrain the incrustation aspect ignored the effect of local microcirculation to wound healing, the present invention not only has infection at present, and the effect of convergence incrustation aspect has blood circulation promoting and blood stasis dispelling simultaneously, dredges microcirculatory effect.Thereby the present invention treats burn can obtain desirable curative effect.At present the used medicine sulfadiazine silver cream of burn is expensive, and the present invention be a Chinese medicine preparation, the prescription science, easy to make, with material cheaply, determined curative effect, treat that local burn has has a broad antifungal spectrum, anti-infectious function is good; Astriction is stronger, helps wound surface and preserves moisture; Accelerate effects such as wound healing.Therefore, the present invention is ideal burn wound surface application compress, reaches the top standard of present like product.
In addition, the present invention also has good antibacterial, blood stasis dispelling and putrefaction removing effect.Experimental result shows that the present invention all has the obvious suppression effect external to common pathogen bacterium and the conditioned pathogen that causes mucocutaneous infections, and mice body white candidiasis is also had the obvious suppression effect; Also has stronger antibacterial action after pointing out contained antibacterials to close to fry in shallow oil.External all has therapeutical effect preferably for experimental skin trauma ecchymosis and skin trauma ulcer; Pathologic finding also shows its edema wound that can obviously disappear, reduces the ecchymosis area; And can promote the healing of ulcer surface, and cicatrix is little, and the time is fast.Experimental result provides the pharmacology foundation for anti-inflammatory analgetic of the present invention, putrefaction removing and tissue regeneration promoting effect.
In addition, the present invention also has good better curative effect aspect the antiinflammatory antiallergic.Experimental result shows, the present invention can significantly suppress animal model inflammatory reaction due to the distinct methods, and can suppress histamine phosphate and cause the reaction of itching, and has comparatively significantly antiinflammatory, itching-relieving action, and is consistent with its clinical anti-inflammatory analgetic, effect such as antipruritic.
Compound preparation of the present invention also can be used for anti-inflammatory analgetic, removes the rotten and lets fresh grow, and promotes the growth of wound surface granulation and epithelial tissue.Be suitable for traumatic infection, open fracture infection, undisguised, granulation growth retardation, ulcer in body surface etc.
The specific embodiment:
Embodiment 1
The preparation of compound preparation
(1) amount of contained component and component is as follows:
Folium Callicarpae Formosanae 16g Rhizoma Curcumae Longae 24g Radix Et Rhizoma Rhei 15g Pseudobulbus Bletillae (Rhizoma Bletillae) 19g
Cortex Phellodendri 14g Radix Ampelopsis 26g Catechu 11g.
(2) preparation method of compound preparation
(1) take by weighing Cortex Phellodendri, Catechu, Radix Et Rhizoma Rhei and the Rhizoma Curcumae Longae of above-mentioned formula ratio, decoct with water 2 hours, collecting decoction is concentrated into 400ml; And adding ethanol to decocting liquid, to contain the alcohol amount be 50%; Left standstill 48 hours, and removed by filter impurity, reclaim ethanol, it is standby to get the residue clear liquid;
(2) Folium Callicarpae Formosanae, the Pseudobulbus Bletillae (Rhizoma Bletillae) and the Radix Ampelopsis that takes by weighing above-mentioned formula ratio decocts with water 2 times, and each 2 hours, merge decoction liquor, be concentrated into 400ml; Add the reserve liquid that obtains in (1) step, stir evenly, add purified water to 1000ml, mixing filters, and packing promptly obtains compound preparation of the present invention.
Embodiment 2
The preparation of compound preparation
(1) amount of contained component and component is as follows:
Folium Callicarpae Formosanae 21g Rhizoma Curcumae Longae 22g Radix Et Rhizoma Rhei 17g Pseudobulbus Bletillae (Rhizoma Bletillae) 18g
Cortex Phellodendri 22g Radix Ampelopsis 25g Catechu 7g.
(2) preparation method of compound preparation
(1) take by weighing Cortex Phellodendri, Catechu, Radix Et Rhizoma Rhei and the Rhizoma Curcumae Longae of above-mentioned formula ratio, decoct with water 2 hours, collecting decoction, and be concentrated into 300ml; And adding ethanol to decocting liquid, to contain the alcohol amount be 50%; Left standstill 48 hours, and removed by filter impurity, reclaim ethanol, it is standby to get the residue clear liquid;
(2) Folium Callicarpae Formosanae, the Pseudobulbus Bletillae (Rhizoma Bletillae) and the Radix Ampelopsis that takes by weighing above-mentioned formula ratio decocts with water 2 times, each 2 hours, merges decoction liquor, and is concentrated into 300ml; Add the reserve liquid that obtains in (1) step, stir evenly, add purified water to 1000ml, mixing filters, and packing promptly obtains compound preparation of the present invention.
Embodiment 3
The preparation of compound preparation
(1) amount of contained component and component is as follows:
Folium Callicarpae Formosanae 19g Rhizoma Curcumae Longae 17g Radix Et Rhizoma Rhei 20g Pseudobulbus Bletillae (Rhizoma Bletillae) 18g
Cortex Phellodendri 15g Radix Ampelopsis 20g Catechu 7g.
(2) preparation method of compound preparation
(1) take by weighing Cortex Phellodendri, Catechu, Radix Et Rhizoma Rhei and the Rhizoma Curcumae Longae of above-mentioned formula ratio, decoct with water 2 hours, collecting decoction is concentrated into 300ml; And adding ethanol to decocting liquid, to contain the alcohol amount be 50%; Left standstill 48 hours, and removed by filter impurity, reclaim ethanol, it is standby to get the residue clear liquid;
(2) Folium Callicarpae Formosanae, the Pseudobulbus Bletillae (Rhizoma Bletillae) and the Radix Ampelopsis that takes by weighing above-mentioned formula ratio decocts with water 2 times, and each 2 hours, merge decoction liquor, be concentrated into 200ml; Add the reserve liquid that obtains in (1) step, stir evenly, add purified water to 1000ml, mixing filters, and packing promptly obtains compound preparation of the present invention.
Embodiment 4
The preparation of compound preparation
(1) amount of contained component and component is as follows:
Folium Callicarpae Formosanae 20g Rhizoma Curcumae Longae 18g Radix Et Rhizoma Rhei 20g Pseudobulbus Bletillae (Rhizoma Bletillae) 18g
Cortex Phellodendri 18g Radix Ampelopsis 18g Catechu 6g.
(2) preparation method of compound preparation
(1) take by weighing Cortex Phellodendri, Catechu, Radix Et Rhizoma Rhei and the Rhizoma Curcumae Longae of above-mentioned formula ratio, decoct with water 2 hours, collecting decoction also is concentrated into 200ml; And adding ethanol to decocting liquid, to contain the alcohol amount be 50%; Left standstill 48 hours, and removed by filter impurity, reclaim ethanol, it is standby to get the supernatant;
(2) Folium Callicarpae Formosanae, the Pseudobulbus Bletillae (Rhizoma Bletillae) and the Radix Ampelopsis that takes by weighing above-mentioned formula ratio decocts with water 2 times, and each 2 hours, merge decoction liquor, be concentrated into 300ml; Add the reserve liquid that obtains in (1) step, stir evenly, add purified water to 1000ml, mixing filters, and packing promptly obtains compound preparation of the present invention.
Embodiment 5
Get embodiment 4 preparation-obtained compound preparations and carry out the effect experiment
(1) clinical research of the compound preparation of embodiment 4 treatment infective wound surface
1, research method
(1) case is selected: behind the acute suppurative infection ulceration of soft tissue, and the ulcer of formation, trauma infection contamination and operative incision infect formed ulcer.The diabetes blood glucose fails the effector; Suffer from limb with thromboangiitis obliterans, varicose veins of the lower extremity person; Method medication person in accordance with regulations not; Internal medicine serious disease (as liver cirrhosis, renal insufficiency, cardiac insufficiency etc.) is arranged; Age＜17 year old,＞75 years old and anemia of pregnant woman; Wound surface area＜1cm
2,＞15cm
2Wound surface is wide＞and 3cm all do not list study subject in.
(2), Therapeutic Method: the treatment group compound preparation of the embodiment 4 of the Drug Manufacturing Room of the court production, the ethacridine that matched group is produced with the Drug Manufacturing Room of the court.The method of changing dressings: wound surface carries out thorough debridement earlier, removes and infects the tissue that rots, and the reuse sterilized cotton ball is stained with medicine washing wound, wipes the pus on the wound surface away, is stained with medicine soak wound surface with the yarn piece of sterilizing then, and every day 2 times, 2 weeks were a course of treatment.Except that the medication difference, two groups of the operation sequences of changing dressings are in full accord.
(3) efficacy assessment standard: divide recovery from illness, produce effects, effective, invalid level Four.Recovery from illness is meant transference cure, wound healing; Produce effects is meant wound healing 2/3, transference cure, and antibacterial culturing is turned out cloudy; Effectively be meant wound healing more than 1/3, sx; The invalid wound healing less than 1/3 that is meant.Wherein wound healing is meant the wound surface scar healing.
2, therapeutic outcome
The compound preparation treatment infective wound surface curative effect of embodiment 4 relatively;
The compound preparation treatment infective wound surface curative effect of table 1 embodiment 4 relatively
| Group | The example number | Recovery from illness (%) | Produce effects (%) | Effectively (%) | Invalid (%) | Total effective rate (%) |
| Embodiment 4 | 50 | 40(80.0) | 6(12.0) | 3(6.0) | 1(2.0) | 49(98.0) |
| Ethacridine | 45 | 20(44.5) | 6(13.0) | 10(22.2) | 9(20.0) | 36(80.0) |
The result shows: the compound preparation group cure rate of embodiment 4 is 80%, and total effective rate is 98%; Ethacridine group cure rate 44.5%, total effective rate are 80%.Show that the present invention treats the infective wound surface curative effect and is better than ethacridine.
The compound preparation of table 2 embodiment 4 is to the influence of infective wound surface antibacterial culturing
| Embodiment 4 | The example number | Staphylococcus aureus | B-mode courageous and upright streptococcus | Escherichia coli | Bacillus pyocyaneus | Other or two kinds of antibacterials | |||||
| Before controlling | After controlling | Before controlling | After controlling | Before controlling | After controlling | Before controlling | After controlling | Before controlling | After controlling | ||
| 50 | 20 | 0 | 8 | 0 | 10 | 1 | 7 | 2 | 5 | 2 | |
The result shows: the compound preparation group infective wound surface of embodiment 4 wound surface antibacterial culturing negative conversion rate after the treatment of 2 weeks is 90.0%, and surperficial compound preparation of the present invention has tangible bacteriostasis.
(2) clinical research of the compound preparation of embodiment 4 treatment burn
1, physical data
(1) case is selected and the result: the wound surface situation is described and is required: by the Chinese rule of Nine and the three degree quartering standard diagnostics wound surface size and the degree of depth, and small area wound record measured value (A * Bcm
2).With 30 routine both sides limbs burn degree ∏ about equally
0The burn and scald patient goes side limbs to treat with the present invention, and all the other wound surface sulfadiazine external application for curing is done the consubstantiality contrast.Wherein male 19 examples, women 11 examples, 8 months to 48 years old age, 9 people below 10 years old, 21 people more than 10 years old, average 19.5 years old.Burn surface area 6～90%, average 37%, minor burn 3 people wherein, moderate burn 15 people, severe burn 4 people, extra heavy burn 8 people.Boiled water is scalded 14 people, and 16 people burn.With trunk top is main 16 people, is main 8 people with the lower torso, and trunk and extremity are injured 6 people simultaneously.Shallow ∏
0Burn and scald 3 people, all the other are mingled with patient for the depth.Injured back 24 hours to examining 25 people, in injured back 48 hours to examining 5 people.
(2) case exclusion standard: and diabetes, senile chronic disease and age are arranged greater than 60 years old.
(3) treatment and observational technique: with 30 routine both sides limbs burn degree ∏ about equally
0The burn and scald patient, wash wound surface successively with 0.1% benzalkonium bromide and normal saline after, get the compound preparation treatment of side limbs, all the other wound surface sulfadiazine silver cream external application for curing with embodiment 4.The treatment group: wound surface is early stage clean after, soak flap coverage after the stock solution of the present invention so that multilamellar (6 layers) yarn piece is full, the wrapping wound surface, directly causes wound healing at every day 1 time.Matched group: wound surface is early stage clean after, wrap up after being coated with wound surface with sulfadiazine silver cream, every day 1 time, directly cause wound healing.Also use antibiotic, symptomatic treatment in the therapeutic process.
(4) efficacy assessment standard; In order to evaluate two groups to ∏
0Burn and scald patient's local curative effect, we from traumatic infection situation, secretions extinction time, begin healing and fully four aspects of healing time carry out therapeutic evaluation.Traumatic infection situation: refer to whether wound surface has infection in the therapeutic process, is as the criterion with antibacterial culturing; Secretions extinction time: refer to that wound exudate disappears, dressing drying when changing dressings; Begin healing and complete healing time: begin healing and refer to that the desquamation healing appears in the wound surface periphery, fully healing refer to wound surface all the area of healing or center less than 2 * 2cm
2
(5) statistical procedures: the result represents that with ē ± s significance test is checked with the t value.
2, clinical treatment result
The compound preparation of embodiment 4 is at treatment ∏
0In burn and scald patient's the process of clinical application, there is routine patient's wound surface that fungal infection is arranged, can not " subcrustal healing " surpluss 3 * 5cm
2The wound surface healing of making skin graft at last.The patient of all healings, behind the burn wound healing, wound surface is smooth substantially, no keloid.The compound preparation of embodiment 4 and SD-Ag disappear at wound exudate, wound surface begins to heal, the clinical effectiveness aspect wound surface healing fully, traumatic infection and the skin-grafting healing sees Table 3:
The compound preparation of table 3 embodiment 4 and SD-Ag therapeutic outcome comparison sheet (ē ± sn=30)
| The wound exudate extinction time (my god) | Wound surface begin healing time (my god) | The complete healing time of wound surface (my god) | The traumatic infection number | Skin-grafting healing number | |
| Treatment group of the present invention | 3.48±2.24 | 4.45±1.51 | 10.96±3.21 | 1 example | 1 example |
| The SD-Ag matched group | 7.62±3.27 | 6.04±1.86 | 15.0±5.68 | 1 example | 1 example |
| The t value | t＝5.72 P＜0.01 | t＝4.55 P＜0.01 | t＝3.39 P＜0.01 |
The compound preparation of embodiment 4 obviously is being better than the SD-Ag matched group aspect the wound surface receipts liquid as seen from Table 2, begin all to be better than the SD-Ag matched group aspect healing time and the complete healing time at wound surface, two groups respectively have a routine traumatic infection and cause the wound surface deepening healing of need making skin graft.
In addition, the compound preparation of embodiment 4 also can be used for anti-inflammatory analgetic, removes the rotten and lets fresh grow, and promotes the growth of wound surface granulation and epithelial tissue.Be suitable for traumatic infection, open fracture infection, undisguised, granulation growth retardation, ulcer in body surface etc.
Claims (6)
1, a kind of compound preparation, in weight portion, make by the material medicine of following umber:
Folium Callicarpae Formosanae 15～22 Rhizoma Curcumae Longaes 17～25 Radix Et Rhizoma Rhei 15～25 Pseudobulbus Bletillae (Rhizoma Bletillae)s 16～20
Cortex Phellodendri 12～30 Radix Ampelopsis 15～30 Catechu 2～12.
2, a kind of compound preparation according to claim 1 is characterized in that in weight portion, is made by the material medicine of following umber:
Folium Callicarpae Formosanae 18～20 Rhizoma Curcumae Longaes 17～20 Radix Et Rhizoma Rhei 18～22 Pseudobulbus Bletillae (Rhizoma Bletillae)s 18～20
Cortex Phellodendri 12～20 Radix Ampelopsis 15～25 Catechu 2～8.
3, a kind of compound preparation according to claim 2 is characterized in that in weight portion, is made by the material medicine of following umber:
Folium Callicarpae Formosanae 20 Rhizoma Curcumae Longaes 18 Radix Et Rhizoma Rhei 20 Pseudobulbus Bletillae (Rhizoma Bletillae)s 18
Cortex Phellodendri 18 Radix Ampelopsis 18 Catechu 6.
4, the preparation method of any described compound preparation in the claim 1～3, form by following steps successively:
(1) in weight portion, take by weighing Cortex Phellodendri, Catechu, Radix Et Rhizoma Rhei and the Rhizoma Curcumae Longae of formula ratio, decoct with water 2 hours, collecting decoction is concentrated into 200～400 parts of solution; And adding ethanol to decocting liquid, to contain the alcohol amount be 50%; Left standstill 48 hours, and removed by filter impurity, reclaim ethanol, it is standby to get the residue clear liquid;
(2) in weight portion, the Folium Callicarpae Formosanae, the Pseudobulbus Bletillae (Rhizoma Bletillae) and the Radix Ampelopsis that take by weighing formula ratio decoct with water 2 times, and each 2 hours, merge decoction liquor, be concentrated into 200～400 parts of solution; Add the reserve liquid that obtains in (1) step, stir evenly, add purified water to 1000 part, mixing filters, and packing promptly obtains product.
5, any described compound preparation is used to prepare application on the medicine for the treatment of infective wound surface in the claim 1～3.
6, any described compound preparation is used to prepare application on the medicine for the treatment of burn in the claim 1～3.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102228623A (en) * | 2011-07-15 | 2011-11-02 | 彭卫新 | Medicinal composition for treating burn and scald and preparation method thereof |
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| CN104116854A (en) * | 2014-08-13 | 2014-10-29 | 付丽娜 | Anti-infectious callicarpa bodinieri injection and preparation method thereof |
| CN105726962A (en) * | 2016-02-29 | 2016-07-06 | 山东大学第二医院 | Traditional Chinese medicine composition for promoting wound healing and preparation method thereof |
| US20240123017A1 (en) * | 2022-10-12 | 2024-04-18 | Chang Gung University Of Science And Technology | Use of Bletilla formosana (Hayata) Schltr. Extract for The Manufacture of A Pharmaceutical Composition For Promoting Chronic Wound Healing |
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2003
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| 创面灵治疗II度烧伤30例临床观察 陈硕敏等，中国中医药科技，第10卷第5期 2003 * |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102228623A (en) * | 2011-07-15 | 2011-11-02 | 彭卫新 | Medicinal composition for treating burn and scald and preparation method thereof |
| CN102228623B (en) * | 2011-07-15 | 2013-04-10 | 彭卫新 | Medicinal composition for treating burn and scald and preparation method thereof |
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| CN1613489A (en) | 2005-05-11 |
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