CN100562326C - A kind of Chinese medicine for outer use for the treatment of burn and preparation method thereof - Google Patents

Abstract

The present invention relates to the Chinese herbal and crude drugs preparations technical field, be specially a kind of Chinese medicine for outer use for the treatment of burn and preparation method thereof, solving existing external use burn treating medicine is difficult for being organized absorption and causes wound surface long by bacterial infection, healing time, the patient there are problems such as anaphylaxis and dosage be big, make by Radix Angelicae Sinensis, Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, Flos Carthami, Radix Arnebiae (Radix Lithospermi), edible vegetable oil, with the edible vegetable oil heated and boiled, add Radix Angelicae Sinensis, wait to explode to sallow duskiness and all pull out; Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae two flavor medicines are followed the prescribed rules respectively; Add Flos Carthami during 30-50 ℃ of fluid temperature decline to be obtained, friedly to little Huang, all pull out; Add Radix Arnebiae (Radix Lithospermi) at last, explode and all pull out to duskiness, the medicinal liquid that obtain this moment is bronzing liquid; Filter, centrifugal after, get supernatant and use.This medicine can be prevented and treated the wound surface bacterial infection, promotes tissue repair, and the short and preventing from scar of healing time has no side effect, and is easy to use, and overall medical expense is low.

Description

A kind of Chinese medicine for outer use for the treatment of burn and preparation method thereof

Technical field

The present invention relates to the Chinese herbal and crude drugs preparations technical field, be specially a kind of Chinese medicine for outer use for the treatment of burn and preparation method thereof.

Background technology

Burn is a kind of common wound, it is one of acute illness of harm humans health, it generally occurs in the skin surface and the deep tissues of human body, can be divided into I, II, III degree by burning the degree of depth, burn and scald causes very easily that skin surface bacterial infection, body fluid exosmose, skin deformation, leave over cicatrix, even cause hyperpyrexia, shock, threat to life, so how to make fire victim's fast speed, high-quality healing, be the target that those skilled in the art pursue always.At present, employed external use burn treating medicine mainly contains three classes, the one, Western medicine preparation on the market; The 2nd, Chinese medicine preparation; The 3rd, the Chinese medicine and western medicine compound formulation, have following defective in clinical the use: 1, great majority are ointment formulation, the drug matrices of this type of burn medicine is difficult for being organized absorption, wound surface will inevitably be the state of dissolving, cause bacterial infection on the one hand easily, the formation of last one deck crust when influencing tissue repair again on the other hand causes wound healing time to prolong; 2, the part external use burn treating medicine has anaphylaxis to the patient, causes obstinate, and the course of disease prolongs; When 3, using ointment formulation, need 1 millimeter approximately in the applied thickness of wound surface, dosage is bigger, and is very high especially for larger area burn treating cost.

Summary of the invention

The present invention is difficult for being organized absorption and causes wound surface long by bacterial infection, healing time in order to solve existing external use burn treating medicine, the patient there are problems such as anaphylaxis and dosage be big, a kind of Chinese medicine for outer use for the treatment of burn and preparation method thereof is provided, has no side effect, healing time is short, can promote tissue repair and prevent the wound surface bacterial infection.

The present invention adopts following technical scheme to realize: the Chinese medicine for outer use of treatment burn, raw material by following weight ratio is made: Radix Angelicae Sinensis 20-30 part, Rhizoma Chuanxiong 20-30 part, Radix Salviae Miltiorrhizae 20-30 part, Flos Carthami 5-15 part, Radix Arnebiae (Radix Lithospermi) 10-20 part, edible vegetable oil 750-1250 part, described edible vegetable oil is Oleum Brassicae campestris or Oleum Arachidis hypogaeae semen; Described Radix Arnebiae (Radix Lithospermi) removes soil and is ground into small pieces, otherwise can influence its drug effect.

Prepare the method for the Chinese medicine for outer use of described treatment burn, may further comprise the steps:

(1) with the edible vegetable oil heated and boiled, add Radix Angelicae Sinensis, wait to explode to sallow duskiness and all pull out;

(2) add Rhizoma Chuanxiong then, wait to explode to sallow duskiness and all pull out;

(3) add Radix Salviae Miltiorrhizae again, wait to explode to sallow duskiness and all pull out;

(4) add Flos Carthami during 30-50 ℃ of fluid temperature decline to be obtained, friedly to little Huang, all pull out;

(5) add Radix Arnebiae (Radix Lithospermi) at last, explode and all pull out to duskiness, the medicinal liquid that obtain this moment is bronzing liquid;

When (6) treating that then fluid temperature is reduced to 20-40 ℃, filter, and with the filtrate natural sedimentation that obtains or use centrifuge centrifugation, get supernatant and can use with the 180-230 mesh sieve.

In the Chinese medicine preparation of the present invention, Radix Angelicae Sinensis, Gan Xin, temperature, warming middle-JIAO to relieve pain, benefiting blood and regulating blood circulation; Rhizoma Chuanxiong, acrid in the mouth is little sweet, temperature, activating QI to alleviate the depression, dispeiling pathogenic wind and removing dampness, promoting blood circulation and stopping pain; Radix Salviae Miltiorrhizae, bitter in the mouth, tepor, blood circulation promoting and blood stasis dispelling, the evacuation of pus pain relieving, granulation promoting is put on flesh, and mends new hemopoietic; Flos Carthami, suffering, temperature, nontoxic, promoting blood circulation to restore menstrual flow, stasis-dispelling and pain-killing; Radix Arnebiae (Radix Lithospermi), hardship is trembled with fear, and removing heat from blood is invigorated blood circulation, heat-clearing and toxic substances removing, sterilization cures mainly burn, and foaming is rotted, and in a word, above-mentioned Chinese medicine of the five flavours is the energy blood circulation promoting and blood stasis dispelling all, improves local blood circulation, promotes histiocyte regeneration.And edible vegetable oil has two effects at this, the one, effective kill bacteria, because being extraneous water-soluble substances, the metabolic process of cell enters in the body by cell wall, and the garbage of self is discharged by cell wall, if cover one deck vegetable oil at the antibacterial outer surface, will have influence on the exchange of the inside and outside water-soluble substances of bacterial cell, cause bacterial metabolism to stop, thereby reach the purpose of kill bacteria; The 2nd, can extract above-mentioned five tastes the effective elements of the medicine by fried mode.

The using method of burn Chinese medicine for outer use of the present invention is as follows: free of contamination fresh wound surface is coating directly, need not to clean; There is the wound surface of pollution should clean wound surface earlier, and then coating, but need not handle wound surface with any disinfectant.

In order to show the therapeutic effect of medicine of the present invention to burn, carried out following clinical experiment, accept fire victim's 484 examples in 3 years altogether for medical treatment, wherein male's 447 examples, women's 37 examples, minimum 15 years old of age, maximum 45 years old, molten iron 454 examples of burning account for 93%, electric arc burn 8 examples, boiling water 17 examples of burning, scum 1 example of burning, flame burn 2 examples, heat is husky, and Colophonium burn is a case each, wherein superficial second degree burn 17 examples, deep second degree burn 151 examples, shallow third degree burn 313 examples, third degree burn 3 examples.Leave the cicatrix after 3 routine deep third degree burn injuries and 6 routine shallow third degree burn healings among these patients that accept for medical treatment, most of shallow third degree burn and deep second degree burn all do not have cicatrization.Shallow two degree of mean treatment natural law 10 days, dark two degree 22 days, shallow three degree 31 days.

Model case:

Case 1: Wu Hainian, the man, 38 years old, the ironworks workman contained in Jiaocheng County, Shanxi Province China, electric arc burn, deep second degree burn, burn surface area are 32%, 20 days treatment times, no cicatrix is left over.

Case 2: Li Hui, the woman, 5 years old, the Shanxi Province, fort radiator factory of Qingxu County Zhao family, boiled water is scalded, and dark two degree are scalded, and burn surface area is 56%, and 15 days treatment times, no cicatrix is left over.

Case 3: simple moral becomes, the man, and 18 years old, the workman of Qingxu County, Shanxi Province radiator factory, the grain slag water scald, deep second degree burn, by additive method treatment traumatic infection after 4 days, burn surface area is 15%, adopts Drug therapy of the present invention to fully recover after 20 days, no cicatrix is left over.

Case 4: Kang Yunfu, the man, 48 years old, the workman of Qingxu, Shanxi Province radiator factory, the grain slag water scald, deep second degree burn, burn surface area are 25%, treat recovery from illness in 14 days, no cicatrix.

Case 5: the youth chrysanthemum, the woman, 29 years old, the workman of Qingxu County, Shanxi Province radiator factory, molten iron burn, shallow third degree burn, burn surface area is 30%, being the some lamellar of loosing, the recovery from illness of 22 days treatment times, no cicatrix.

Case 6: Zhao Qinglun, the man, 27 years old, the workman of Qingxu County, Shanxi Province radiator factory, the molten iron burn, dark two degree, third degree burn, burn surface area is 5%, face, cervical region, chest, recovery from illness in 15 days, no cicatrix; Foot, the wrist portion third degree burn, little cicatrix is stayed in healing in 43 days.

Case 7: Pan Xiao Pan, the woman, 4 years old, boiled water was scalded, deep second degree burn, local woanded surface is three degree because of infecting intensification, burn surface area is 6%, by additive method treatment traumatic infection suppuration after 53 days, adopts Drug therapy of the present invention healing in 48 days, leaves less cicatrix.

In sum, the Chinese medicine for outer use of treatment burn of the present invention has following curative effect:

1, anti-, control the wound surface bacterial infection: because any microorganism all is not suitable for surviving, so to the suppuration of effectively protecting from infection of infective wound surface not on this medicine coating; To the wound surface control infection rapidly of suppurating.So this medicine all can effectively prevent bacterial infection or control the suppurative bacterium infection rapidly other skin injury except that burn or various skin infection;

2, promote the damaged tissue reparation: this medicine is applied directly to damaged tissue and absorbs, medicine improves local blood circulation by local action with the whole body regulating action after absorbing, and transfers whole body and partial reparative factor, promote histiocytic regeneration, quicken wound healing.In addition, this medicine has stronger liquefacttus effect to containing the more slough of collagen composition, and having avoided influences tissue repair because of eschar forms dry sclerosis, even deepens depth of burn, thereby is adapt circumstance of reparation creation of damaged tissue;

3, leaving no scar after healing: can keep the epithelial tissue of remaining work and the appendages of skin, skin progenitor cell to greatest extent, epithelial tissue is regenerated rapidly, covers wound repairing;

4, have no side effect, easy to use, overall medical expense is low: this medicine is that pure Chinese medicine purification processing is made, and is without any side effects, because this medicine is thinner, surface covered is relatively large, is 4-5 times of ointment; Generally without dressing; Healing rate is fast, the hospital stays is short, so overall medical expense is lower.

The specific embodiment

Embodiment 1: every part is 1 gram

The Chinese medicine for outer use of treatment burn, make by the raw material of following weight ratio: Radix Angelicae Sinensis 20 grams, Rhizoma Chuanxiong 20 grams, Radix Salviae Miltiorrhizae 20 grams, Flos Carthami 5 grams, Radix Arnebiae (Radix Lithospermi) 10 grams, edible vegetable oil 750 grams, described edible vegetable oil is Oleum Brassicae campestris.Preparation method may further comprise the steps: with the Oleum Brassicae campestris heated and boiled, add Radix Angelicae Sinensis, wait to explode to sallow duskiness and all pull out; Add Rhizoma Chuanxiong then, wait to explode to sallow duskiness and all pull out; Add Radix Salviae Miltiorrhizae again, wait to explode to sallow duskiness and all pull out; Fluid temperature to be obtained descends and adds Flos Carthami 30 ℃ the time, friedly all pulls out to little Huang; Add Radix Arnebiae (Radix Lithospermi) at last, explode and all pull out to duskiness, the medicinal liquid that obtain this moment is bronzing liquid; When treating that then fluid temperature is reduced to 20 ℃, filter with 180 mesh sieves, and, get supernatant and can use the filtrate natural sedimentation that obtains.

Embodiment 2: 1 kilogram every part

The Chinese medicine for outer use of treatment burn, make by the raw material of following weight ratio: 30 kilograms of Radix Angelicae Sinensis, 30 kilograms of Rhizoma Chuanxiongs, 30 kilograms of Radix Salviae Miltiorrhizaes, 15 kilograms on Flos Carthami, 20 kilograms of Radix Arnebiae (Radix Lithospermi)s, 1250 kilograms of edible vegetable oils, described edible vegetable oil are Oleum Arachidis hypogaeae semen.Preparation method may further comprise the steps: with the Oleum Arachidis hypogaeae semen heated and boiled, add Radix Angelicae Sinensis, wait to explode to sallow duskiness and all pull out; Add Rhizoma Chuanxiong then, wait to explode to sallow duskiness and all pull out; Add Radix Salviae Miltiorrhizae again, wait to explode to sallow duskiness and all pull out; Fluid temperature to be obtained descends and adds Flos Carthami 50 ℃ the time, friedly all pulls out to little Huang; Add Radix Arnebiae (Radix Lithospermi) at last, explode and all pull out to duskiness, the medicinal liquid that obtain this moment is bronzing liquid; When treating that then fluid temperature is reduced to 40 ℃, filter, and the filtrate that obtains is used centrifuge centrifugation, get supernatant and can use with 230 mesh sieves.

Embodiment 3: 1 liang every part

The Chinese medicine for outer use of treatment burn, make by the raw material of following weight ratio: 25 liang of Radix Angelicae Sinensis, 25 liang of Rhizoma Chuanxiongs, 25 liang of Radix Salviae Miltiorrhizaes, 10 liang on Flos Carthami, 15 liang of Radix Arnebiae (Radix Lithospermi)s, 1000 liang of edible vegetable oils, described edible vegetable oil are Oleum Brassicae campestris.Preparation method may further comprise the steps: with the Oleum Brassicae campestris heated and boiled, add Radix Angelicae Sinensis, wait to explode to sallow duskiness and all pull out; Add Rhizoma Chuanxiong then, wait to explode to sallow duskiness and all pull out; Add Radix Salviae Miltiorrhizae again, wait to explode to sallow duskiness and all pull out; Fluid temperature to be obtained descends and adds Flos Carthami 40 ℃ the time, friedly all pulls out to little Huang; Add Radix Arnebiae (Radix Lithospermi) at last, explode and all pull out to duskiness, the medicinal liquid that obtain this moment is bronzing liquid; When treating that then fluid temperature is reduced to 30 ℃, filter, and the filtrate that obtains is used centrifuge centrifugation, get supernatant and can use with 200 mesh sieves.

Embodiment 4: 1 jin every part

The Chinese medicine for outer use of treatment burn, make by the raw material of following weight ratio: 28 jin of Radix Angelicae Sinensis, 24 jin of Rhizoma Chuanxiongs, 20 jin of Radix Salviae Miltiorrhizaes, 10 jin on Flos Carthami, 16 jin of Radix Arnebiae (Radix Lithospermi)s, 980 jin of edible vegetable oils, described edible vegetable oil are Oleum Arachidis hypogaeae semen.Preparation method may further comprise the steps: with the Oleum Arachidis hypogaeae semen heated and boiled, add Radix Angelicae Sinensis, wait to explode to sallow duskiness and all pull out; Add Rhizoma Chuanxiong then, wait to explode to sallow duskiness and all pull out; Add Radix Salviae Miltiorrhizae again, wait to explode to sallow duskiness and all pull out; Fluid temperature to be obtained descends and adds Flos Carthami 45 ℃ the time, friedly all pulls out to little Huang; Add Radix Arnebiae (Radix Lithospermi) at last, explode and all pull out to duskiness, the medicinal liquid that obtain this moment is bronzing liquid; When treating that then fluid temperature is reduced to 35 ℃, filter with 215 mesh sieves, and, get supernatant and can use the filtrate natural sedimentation that obtains.

Claims (2)

1, a kind of Chinese medicine for outer use for the treatment of burn is characterized in that being made by the raw material of following weight ratio:

Radix Angelicae Sinensis 20-30 part Rhizoma Chuanxiong 20-30 part Radix Salviae Miltiorrhizae 20-30 part Flos Carthami 5-15 part Radix Arnebiae (Radix Lithospermi) 10-20 part edible vegetable oil 750-1250 part;

Its preparation method may further comprise the steps:

(1) with the edible vegetable oil heated and boiled, add Radix Angelicae Sinensis, wait to explode to sallow duskiness and all pull out;

(2) add Rhizoma Chuanxiong then, wait to explode to sallow duskiness and all pull out;

(3) add Radix Salviae Miltiorrhizae again, wait to explode to sallow duskiness and all pull out;

(4) add Flos Carthami during 30-50 ℃ of fluid temperature decline to be obtained, friedly to little Huang, all pull out;

(5) at last Radix Arnebiae (Radix Lithospermi) is gone soil and be ground into small pieces after add, fried to duskiness, all pull out, the medicinal liquid that obtain this moment is bronzing liquid;

When (6) treating that then fluid temperature is reduced to 20-40 ℃, filter, and with the filtrate natural sedimentation that obtains or use centrifuge centrifugation, get supernatant and can use with the 180-230 mesh sieve.

2, a kind of Chinese medicine for outer use for the treatment of burn according to claim 1 is characterized in that described edible vegetable oil is Oleum Brassicae campestris or Oleum Arachidis hypogaeae semen.