CN1259087C - Medicine for treating trauma and sores and its preparing process - Google Patents
Medicine for treating trauma and sores and its preparing process Download PDFInfo
- Publication number
- CN1259087C CN1259087C CN 200310105917 CN200310105917A CN1259087C CN 1259087 C CN1259087 C CN 1259087C CN 200310105917 CN200310105917 CN 200310105917 CN 200310105917 A CN200310105917 A CN 200310105917A CN 1259087 C CN1259087 C CN 1259087C
- Authority
- CN
- China
- Prior art keywords
- medicine
- parts
- wound
- present
- healing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000003814 drug Substances 0.000 title claims abstract description 89
- 229940079593 drug Drugs 0.000 title claims abstract description 17
- 238000000034 method Methods 0.000 title claims abstract description 10
- 208000014674 injury Diseases 0.000 title abstract description 15
- 230000008733 trauma Effects 0.000 title abstract description 9
- 230000008569 process Effects 0.000 title description 5
- 230000035876 healing Effects 0.000 claims abstract description 27
- 238000002360 preparation method Methods 0.000 claims abstract description 16
- 241000717739 Boswellia sacra Species 0.000 claims abstract description 11
- 239000004863 Frankincense Substances 0.000 claims abstract description 11
- 239000011787 zinc oxide Substances 0.000 claims abstract description 9
- 239000000843 powder Substances 0.000 claims description 22
- 244000153234 Hibiscus abelmoschus Species 0.000 claims description 17
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 claims description 16
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 claims description 14
- 239000000796 flavoring agent Substances 0.000 claims description 14
- 235000019634 flavors Nutrition 0.000 claims description 14
- PFTAWBLQPZVEMU-DZGCQCFKSA-N (+)-catechin Chemical compound C1([C@H]2OC3=CC(O)=CC(O)=C3C[C@@H]2O)=CC=C(O)C(O)=C1 PFTAWBLQPZVEMU-DZGCQCFKSA-N 0.000 claims description 11
- 235000006226 Areca catechu Nutrition 0.000 claims description 11
- 239000009286 sanguis draxonis Substances 0.000 claims description 11
- 229960003600 silver sulfadiazine Drugs 0.000 claims description 10
- 244000080767 Areca catechu Species 0.000 claims description 7
- 239000000463 material Substances 0.000 claims description 6
- 238000002156 mixing Methods 0.000 claims description 6
- 238000012545 processing Methods 0.000 claims description 6
- 244000235603 Acacia catechu Species 0.000 claims description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 5
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims description 4
- 239000011701 zinc Substances 0.000 claims description 4
- 229910052725 zinc Inorganic materials 0.000 claims description 4
- 238000004587 chromatography analysis Methods 0.000 claims description 3
- 239000002552 dosage form Substances 0.000 claims description 3
- 239000004570 mortar (masonry) Substances 0.000 claims description 3
- 238000005303 weighing Methods 0.000 claims description 3
- 238000012856 packing Methods 0.000 claims description 2
- UEJSSZHHYBHCEL-UHFFFAOYSA-N silver(1+) sulfadiazinate Chemical compound [Ag+].C1=CC(N)=CC=C1S(=O)(=O)[N-]C1=NC=CC=N1 UEJSSZHHYBHCEL-UHFFFAOYSA-N 0.000 claims 3
- 206010052428 Wound Diseases 0.000 abstract description 60
- 208000027418 Wounds and injury Diseases 0.000 abstract description 60
- 208000002193 Pain Diseases 0.000 abstract description 24
- 230000036407 pain Effects 0.000 abstract description 24
- 208000025865 Ulcer Diseases 0.000 abstract description 23
- 231100000397 ulcer Toxicity 0.000 abstract description 22
- 208000015181 infectious disease Diseases 0.000 abstract description 20
- 230000001684 chronic effect Effects 0.000 abstract description 15
- 230000023597 hemostasis Effects 0.000 abstract description 7
- 230000001338 necrotic effect Effects 0.000 abstract description 7
- 230000029663 wound healing Effects 0.000 abstract description 7
- 150000001875 compounds Chemical class 0.000 abstract description 6
- 206010061218 Inflammation Diseases 0.000 abstract description 4
- 230000006870 function Effects 0.000 abstract description 4
- 230000001225 therapeutic effect Effects 0.000 abstract description 4
- 230000004054 inflammatory process Effects 0.000 abstract description 3
- 239000009306 yunnan baiyao Substances 0.000 abstract description 3
- 241000894006 Bacteria Species 0.000 abstract description 2
- 208000003251 Pruritus Diseases 0.000 abstract description 2
- 206010072170 Skin wound Diseases 0.000 abstract description 2
- 239000002994 raw material Substances 0.000 abstract description 2
- 239000000126 substance Substances 0.000 abstract description 2
- 230000004083 survival effect Effects 0.000 abstract description 2
- 229940126673 western medicines Drugs 0.000 abstract description 2
- 229940105847 calamine Drugs 0.000 abstract 1
- 239000009136 dragon's blood Substances 0.000 abstract 1
- 210000001126 granulation tissue Anatomy 0.000 abstract 1
- 229910052864 hemimorphite Inorganic materials 0.000 abstract 1
- 230000007803 itching Effects 0.000 abstract 1
- 229940126680 traditional chinese medicines Drugs 0.000 abstract 1
- 235000014692 zinc oxide Nutrition 0.000 abstract 1
- CPYIZQLXMGRKSW-UHFFFAOYSA-N zinc;iron(3+);oxygen(2-) Chemical compound [O-2].[O-2].[O-2].[O-2].[Fe+3].[Fe+3].[Zn+2] CPYIZQLXMGRKSW-UHFFFAOYSA-N 0.000 abstract 1
- 230000000694 effects Effects 0.000 description 23
- 201000004624 Dermatitis Diseases 0.000 description 17
- 230000001737 promoting effect Effects 0.000 description 17
- 208000010668 atopic eczema Diseases 0.000 description 16
- 210000003141 lower extremity Anatomy 0.000 description 12
- 238000005469 granulation Methods 0.000 description 11
- 230000003179 granulation Effects 0.000 description 11
- 230000003110 anti-inflammatory effect Effects 0.000 description 10
- 210000001519 tissue Anatomy 0.000 description 9
- 239000010201 sheng-ji-san Substances 0.000 description 8
- 230000000844 anti-bacterial effect Effects 0.000 description 7
- CIKWKGFPFXJVGW-UHFFFAOYSA-N ethacridine Chemical compound C1=C(N)C=CC2=C(N)C3=CC(OCC)=CC=C3N=C21 CIKWKGFPFXJVGW-UHFFFAOYSA-N 0.000 description 7
- 229960001588 ethacridine Drugs 0.000 description 7
- 210000004185 liver Anatomy 0.000 description 7
- 238000011160 research Methods 0.000 description 7
- SEEPANYCNGTZFQ-UHFFFAOYSA-N sulfadiazine Chemical compound C1=CC(N)=CC=C1S(=O)(=O)NC1=NC=CC=N1 SEEPANYCNGTZFQ-UHFFFAOYSA-N 0.000 description 7
- 239000008280 blood Substances 0.000 description 6
- 210000004369 blood Anatomy 0.000 description 6
- 238000005516 engineering process Methods 0.000 description 6
- 230000008736 traumatic injury Effects 0.000 description 6
- 230000001139 anti-pruritic effect Effects 0.000 description 5
- 239000003908 antipruritic agent Substances 0.000 description 5
- 230000017531 blood circulation Effects 0.000 description 5
- 210000003491 skin Anatomy 0.000 description 5
- 230000008961 swelling Effects 0.000 description 5
- 238000012360 testing method Methods 0.000 description 5
- 208000032843 Hemorrhage Diseases 0.000 description 4
- 206010040943 Skin Ulcer Diseases 0.000 description 4
- 206010053615 Thermal burn Diseases 0.000 description 4
- 235000009508 confectionery Nutrition 0.000 description 4
- 238000011109 contamination Methods 0.000 description 4
- 238000002474 experimental method Methods 0.000 description 4
- 231100000614 poison Toxicity 0.000 description 4
- 230000008092 positive effect Effects 0.000 description 4
- 230000028327 secretion Effects 0.000 description 4
- 206010040872 skin infection Diseases 0.000 description 4
- 231100000019 skin ulcer Toxicity 0.000 description 4
- 230000000472 traumatic effect Effects 0.000 description 4
- 206010010904 Convulsion Diseases 0.000 description 3
- 208000033809 Suppuration Diseases 0.000 description 3
- 206010046996 Varicose vein Diseases 0.000 description 3
- 238000009825 accumulation Methods 0.000 description 3
- 208000002399 aphthous stomatitis Diseases 0.000 description 3
- 230000008859 change Effects 0.000 description 3
- 230000036461 convulsion Effects 0.000 description 3
- 238000009472 formulation Methods 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 210000000952 spleen Anatomy 0.000 description 3
- 229940124530 sulfonamide Drugs 0.000 description 3
- 230000002110 toxicologic effect Effects 0.000 description 3
- 231100000027 toxicology Toxicity 0.000 description 3
- 208000027185 varicose disease Diseases 0.000 description 3
- 241001419719 Anisodus carniolicoides Species 0.000 description 2
- 206010051548 Burn infection Diseases 0.000 description 2
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- 206010008190 Cerebrovascular accident Diseases 0.000 description 2
- 206010010071 Coma Diseases 0.000 description 2
- 206010051625 Conjunctival hyperaemia Diseases 0.000 description 2
- 241001165596 Hylotelephium erythrostictum Species 0.000 description 2
- 206010062717 Increased upper airway secretion Diseases 0.000 description 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- 206010068319 Oropharyngeal pain Diseases 0.000 description 2
- 201000007100 Pharyngitis Diseases 0.000 description 2
- 241000589517 Pseudomonas aeruginosa Species 0.000 description 2
- 206010040880 Skin irritation Diseases 0.000 description 2
- 208000006011 Stroke Diseases 0.000 description 2
- UCKMPCXJQFINFW-UHFFFAOYSA-N Sulphide Chemical compound [S-2] UCKMPCXJQFINFW-UHFFFAOYSA-N 0.000 description 2
- 206010048038 Wound infection Diseases 0.000 description 2
- 230000000202 analgesic effect Effects 0.000 description 2
- 230000000740 bleeding effect Effects 0.000 description 2
- 208000010217 blepharitis Diseases 0.000 description 2
- 229910052956 cinnabar Inorganic materials 0.000 description 2
- 239000006071 cream Substances 0.000 description 2
- 239000013078 crystal Substances 0.000 description 2
- 238000002425 crystallisation Methods 0.000 description 2
- 230000008025 crystallization Effects 0.000 description 2
- 238000007598 dipping method Methods 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 230000003628 erosive effect Effects 0.000 description 2
- 229910052500 inorganic mineral Inorganic materials 0.000 description 2
- 210000004072 lung Anatomy 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000011707 mineral Substances 0.000 description 2
- 235000010755 mineral Nutrition 0.000 description 2
- 210000003205 muscle Anatomy 0.000 description 2
- 230000037257 muscle growth Effects 0.000 description 2
- 231100000252 nontoxic Toxicity 0.000 description 2
- 230000003000 nontoxic effect Effects 0.000 description 2
- 230000000144 pharmacologic effect Effects 0.000 description 2
- 208000026435 phlegm Diseases 0.000 description 2
- 238000000554 physical therapy Methods 0.000 description 2
- 239000002574 poison Substances 0.000 description 2
- 230000007096 poisonous effect Effects 0.000 description 2
- 230000002829 reductive effect Effects 0.000 description 2
- 239000011347 resin Substances 0.000 description 2
- 229920005989 resin Polymers 0.000 description 2
- 230000036556 skin irritation Effects 0.000 description 2
- 231100000475 skin irritation Toxicity 0.000 description 2
- FDDDEECHVMSUSB-UHFFFAOYSA-N sulfanilamide Chemical compound NC1=CC=C(S(N)(=O)=O)C=C1 FDDDEECHVMSUSB-UHFFFAOYSA-N 0.000 description 2
- 206010042772 syncope Diseases 0.000 description 2
- 229910000010 zinc carbonate Inorganic materials 0.000 description 2
- 201000000736 Amenorrhea Diseases 0.000 description 1
- 206010001928 Amenorrhoea Diseases 0.000 description 1
- 206010002198 Anaphylactic reaction Diseases 0.000 description 1
- 241001050829 Arnebia guttata Species 0.000 description 1
- 241000193830 Bacillus <bacterium> Species 0.000 description 1
- 208000035143 Bacterial infection Diseases 0.000 description 1
- 241001608538 Boswellia Species 0.000 description 1
- 229910021532 Calcite Inorganic materials 0.000 description 1
- 244000001582 Canarium odontophyllum Species 0.000 description 1
- 235000016299 Canarium odontophyllum Nutrition 0.000 description 1
- 241000700199 Cavia porcellus Species 0.000 description 1
- 206010007882 Cellulitis Diseases 0.000 description 1
- 241000282994 Cervidae Species 0.000 description 1
- 206010010726 Conjunctival oedema Diseases 0.000 description 1
- 206010012435 Dermatitis and eczema Diseases 0.000 description 1
- 206010013654 Drug abuse Diseases 0.000 description 1
- 208000000059 Dyspnea Diseases 0.000 description 1
- 206010013975 Dyspnoeas Diseases 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- 208000010201 Exanthema Diseases 0.000 description 1
- 208000015220 Febrile disease Diseases 0.000 description 1
- 206010020649 Hyperkeratosis Diseases 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 206010061245 Internal injury Diseases 0.000 description 1
- 208000001126 Keratosis Diseases 0.000 description 1
- 241001071917 Lithospermum Species 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 241000475481 Nebula Species 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- 240000007817 Olea europaea Species 0.000 description 1
- 244000021150 Orbignya martiana Species 0.000 description 1
- 235000014643 Orbignya martiana Nutrition 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- 206010033557 Palpitations Diseases 0.000 description 1
- 240000005373 Panax quinquefolius Species 0.000 description 1
- 235000003140 Panax quinquefolius Nutrition 0.000 description 1
- 208000008469 Peptic Ulcer Diseases 0.000 description 1
- 241000588769 Proteus <enterobacteria> Species 0.000 description 1
- 206010037660 Pyrexia Diseases 0.000 description 1
- 206010039509 Scab Diseases 0.000 description 1
- 206010040840 Skin erosion Diseases 0.000 description 1
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 description 1
- 241000191967 Staphylococcus aureus Species 0.000 description 1
- 241000193990 Streptococcus sp. 'group B' Species 0.000 description 1
- 208000002847 Surgical Wound Diseases 0.000 description 1
- 240000002299 Symphytum officinale Species 0.000 description 1
- 235000005865 Symphytum officinale Nutrition 0.000 description 1
- 206010053476 Traumatic haemorrhage Diseases 0.000 description 1
- 240000008042 Zea mays Species 0.000 description 1
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 1
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 1
- FMRLDPWIRHBCCC-UHFFFAOYSA-L Zinc carbonate Chemical compound [Zn+2].[O-]C([O-])=O FMRLDPWIRHBCCC-UHFFFAOYSA-L 0.000 description 1
- 210000001015 abdomen Anatomy 0.000 description 1
- 238000003677 abuse test Methods 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 231100000215 acute (single dose) toxicity testing Toxicity 0.000 description 1
- 238000011047 acute toxicity test Methods 0.000 description 1
- 231100000540 amenorrhea Toxicity 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- 230000036783 anaphylactic response Effects 0.000 description 1
- 208000003455 anaphylaxis Diseases 0.000 description 1
- 210000003423 ankle Anatomy 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 230000002421 anti-septic effect Effects 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 235000019606 astringent taste Nutrition 0.000 description 1
- 208000022362 bacterial infectious disease Diseases 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- OSGAYBCDTDRGGQ-UHFFFAOYSA-L calcium sulfate Chemical compound [Ca+2].[O-]S([O-])(=O)=O OSGAYBCDTDRGGQ-UHFFFAOYSA-L 0.000 description 1
- 230000001914 calming effect Effects 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 229910002092 carbon dioxide Inorganic materials 0.000 description 1
- 239000001569 carbon dioxide Substances 0.000 description 1
- 229910001748 carbonate mineral Inorganic materials 0.000 description 1
- 229940116318 copper carbonate Drugs 0.000 description 1
- GEZOTWYUIKXWOA-UHFFFAOYSA-L copper;carbonate Chemical compound [Cu+2].[O-]C([O-])=O GEZOTWYUIKXWOA-UHFFFAOYSA-L 0.000 description 1
- 235000005822 corn Nutrition 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 230000003467 diminishing effect Effects 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 210000002615 epidermis Anatomy 0.000 description 1
- 201000005884 exanthem Diseases 0.000 description 1
- 230000005284 excitation Effects 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 210000003414 extremity Anatomy 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 210000000232 gallbladder Anatomy 0.000 description 1
- 208000014617 hemorrhoid Diseases 0.000 description 1
- 239000004021 humic acid Substances 0.000 description 1
- 210000003026 hypopharynx Anatomy 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 206010022437 insomnia Diseases 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 230000010354 integration Effects 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 239000009416 jing wan hong Substances 0.000 description 1
- 230000003780 keratinization Effects 0.000 description 1
- 230000003907 kidney function Effects 0.000 description 1
- 230000002147 killing effect Effects 0.000 description 1
- 210000000088 lip Anatomy 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 230000003211 malignant effect Effects 0.000 description 1
- 230000013011 mating Effects 0.000 description 1
- 229930014626 natural product Natural products 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- 230000009965 odorless effect Effects 0.000 description 1
- 244000045947 parasite Species 0.000 description 1
- 230000032696 parturition Effects 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 210000003516 pericardium Anatomy 0.000 description 1
- 210000005059 placental tissue Anatomy 0.000 description 1
- 231100000572 poisoning Toxicity 0.000 description 1
- 230000000607 poisoning effect Effects 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000005180 public health Effects 0.000 description 1
- NIFIFKQPDTWWGU-UHFFFAOYSA-N pyrite Chemical compound [Fe+2].[S-][S-] NIFIFKQPDTWWGU-UHFFFAOYSA-N 0.000 description 1
- 229910052683 pyrite Inorganic materials 0.000 description 1
- 239000011028 pyrite Substances 0.000 description 1
- 206010037844 rash Diseases 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 208000009146 rhinoscleroma Diseases 0.000 description 1
- 210000003752 saphenous vein Anatomy 0.000 description 1
- 238000006748 scratching Methods 0.000 description 1
- 230000002393 scratching effect Effects 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 230000035939 shock Effects 0.000 description 1
- 239000002002 slurry Substances 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 208000011117 substance-related disease Diseases 0.000 description 1
- QXKXDIKCIPXUPL-UHFFFAOYSA-N sulfanylidenemercury Chemical compound [Hg]=S QXKXDIKCIPXUPL-UHFFFAOYSA-N 0.000 description 1
- 150000003456 sulfonamides Chemical class 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 230000017423 tissue regeneration Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 239000011573 trace mineral Substances 0.000 description 1
- 235000013619 trace mineral Nutrition 0.000 description 1
- 230000036269 ulceration Effects 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- 239000011667 zinc carbonate Substances 0.000 description 1
- 235000004416 zinc carbonate Nutrition 0.000 description 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
The present invention relates to a medicament for treating trauma and sores and a preparing method thereof. At present, medicaments commonly used in clinic, such as Huotang paste, Huatuo paste, jingwanghong paste, Yunnan baiyao and the like has certain therapeutic functions for reducing pain of wounded people, accelerating trauma healing and improving the survival rate of skin grafting. But, the medicaments have poor healing therapeutic effects on deep skin wounds, wound suppurative infection, chronic intractable ulcers of body skin and other wounds. In the present invention, a multifunctional compound preparation of traditional Chinese and western medicines is prepared by combining the natural medicines of traditional Chinese medicine with chemical medicines. The preparation adopts calamine, dragon blood, olibanum and the like as raw materials, having the functions of hemostasis, bacterium resistance, inflammation relief, removal of necrotic tissue, granulation promotion, convergence, itching relief, pain alleviation, wound healing promotion, etc.
Description
One, technical field:
The present invention relates to a kind of medicine for the treatment of the wound sore healing and preparation method thereof; Specifically synthesize raw material with natural drug Chinese medicine and chemicals, a kind of skin and the wound infection of being used for that forms through existing technology method Processing of Preparation is in the diseases such as exudative eczema, body surface chronic and refractory ulcer and burn, scald, compound Western medicine preparation and preparation method thereof.
Two, technical background:
At present, the medicine of market treatment wound, burn, scald is a lot, but curative effect is different, clinical common burning hot cream, HUATUO GAO, medicines such as JINGWANHONG cream, YUNNAN BAIYAO quicken the wound healing to a certain extent to alleviating the wounded's slight illness, promote the epidermis skin graft survival rate that certain therapeutical effect is arranged.But the dense sexuality of wound, woundization for deep skin is dyed, and therapeutic wound healing effects such as body surface chronic and refractory ulcer are not good enough.Therefore, sought the more profound clinical theoretical research wound of efficacious prescriptions medicine, the dense sexuality of deep layer woundization is dyed, and body surface chronic and refractory Peptic Ulcers has the science clinical meaning of reality.
Three, summary of the invention:
The object of the present invention is to provide a kind of existing hemostasis, again stronger anti-inflammation arranged, also have the medicine and preparation method thereof that removing the necrotic tissue and promoting granulation, antipruritic, the pain relieving of convergence promote the treatment wound sore healing of multifunctional usage such as wound healing.
In order to achieve the above object, its technical scheme that adopts is as follows:
A kind of medicine for the treatment of the wound sore healing, its special character is: described Chinese medicine is made by following materials of weight proportions:
Calamina 560-600 part Sanguis Draxonis 18-24 part
System Aerugo 8-14 part Olibanum (processed) 10-30 part
Pyritum (calcined) 10-30 part Radix Arnebiae (Radix Lithospermi) 20-40 part
Cinnabaris 15-35 part silver sulfadiazine 30-50 part
Borneolum Syntheticum 20-40 part zinc oxide 150-250 part
Catechu 10-30 part Moschus 0.5-3 part
Above-mentioned Chinese medicine is made by following materials of weight proportions:
22 parts of 580 parts of Sanguis Draxonis of Calamina
20 parts of 12 parts of Olibanum (processed)s of system Aerugo
30 parts of 20 portions of Radix Arnebiae (Radix Lithospermi)s of Pyritum (calcined)
40 parts of 25 parts of silver sulfadiazine of Cinnabaris
200 parts of 30 parts of zinc oxide of Borneolum Syntheticum
1 part in 20 parts of Moschus of catechu
Above-mentioned dosage form is that the processing step of preparation method of external pulvis is as follows:
(1), Moschus, Borneolum Syntheticum put be ground into fine powder in the mortar, by No. six sieves, Cinnabaris water flies porphyrize or is ground into superfine powder, and is standby;
(2), with Calamina, Pyritum, system Aerugo, oxide powder and zinc be broken into impalpable powder, by No. eight the sieve, standby;
(3), catechu, Sanguis Draxonis, Olibanum (processed), Radix Arnebiae (Radix Lithospermi), silver sulfadiazine five kinds of Chinese medicine are ground into fine powder, by No. five sieves, step (1), (2) bottoming chromatography are being added Cinnabaris, behind the mixing, by the equivalent incremental method Moschus, Borneolum Syntheticum two flavor medicines are being mixed with above-mentioned thin medicated powder again, cross 100 mesh sieves, in the mixing apparatus container, stirred 40 minutes, full and uniform after, take out, weighing, by the description packing promptly
The present invention is with respect to prior art, and its advantage is as follows:
This invention is a utilization current clinical medicine knowledge, excavates motherland's medical heritage and the Chinese medicine and western medicine compound formulation based on Chinese medicine developed.It has antiinflammatory, pain relieving, stop blooding, invigorate blood circulation, removing the necrotic tissue and promoting granulation, to hold back skin ulcer antipruritic, promote all kinds of wound healing effects, be mainly used in: 1, the various fresh and firearm wounds that infect in the war, 2, the wound of the fresh and infection of various general traumatic injury, 3, the body surface chronic and refractory ulcer due to varicose veins of the lower extremity and other reason, 4, the burn of various fresh infection, scald wound, 5, the eczema wound of concurrent infection.
Its characteristics are: 1, applied range surpasses in domestic and international any external at present on indication, western drug.It not only has the good curing effect to various outer wound fresh and that infect, and to burn, eczema infects and lower limb chronic and refractory ulcer has clinical effectiveness simultaneously.
2, drug quality is stable, and is evident in efficacy, in the present external, Western medicine can not compare.
3, have broad-spectrum antibacterial action, short treating period, instant effect, side effect is little, and the keeping that is easy to carry is easy to use.
The present invention adopts existing common process technology usually, and the process route hierarchy of operation is clear, selection is genuine, concocted specification, and production technology is feasible, drug quality guarantees, and is easy to use, is subjected to patient's welcome deeply.
Four, specific embodiment:
The present invention is based on modern clinical experience,, the 12 flavor property of medicine in the prescription carried out as detailed below in conjunction with clinical practice and case with reference to modern medical theory research:
(1), Calamina: for the smithsonite master of carbonate mineral calcite family contains zinc carbonate (ZnCO
3)
Nature and flavor: sweet, flat, return the stomach warp;
Performance characteristics: the detoxifcation improving acuity of vision and removing nebula, restrain the antipruritic skin ulcer of holding back.Be used for conjunctival congestion and swelling pain, marginal blepharitis, ulcer being unable to heal, dripping, the eczema of pus, skin pruritus.
2, Sanguis Draxonis: the resin that oozes out for babassu Sanguis Draxonis fruit is through being processed into.
Nature and flavor: sweet, one-tenth is flat.GUIXIN, Liver Channel;
Performance characteristics: removing blood stasis and relieving pain, hemostasia and promoting granulation; Be used for traumatic injury and lose, ecchymoma due to internal injury, continuous bleeding due to traumatic injury.
3, Olibanum: be the gum resin of olive subject plant Boswellia carterii Birdw.Nature and flavor are arduous, temperature, return through: go into the heart, liver spleen channel.
Performance characteristics: promoting blood circulation and stopping pain, detumescence and promoting granulation.Be used for traumatic pain, ulcer sore pain, the skin infection diabrosis is not closed up for a long time.
4, system Aerugo: be to add water with Aerugo powder or Malachitum (being the basic copper carbonate of natural product) and Gypsum Fibrosum preparata to mix and stir and be cut into bulk, spray forms surface generation green with jowar wine.
Nature and flavor: sour and astringent, flat, poisonous.Return liver, gallbladder meridian.
Performance characteristics: removing the necrotic tissue, hold back skin ulcer, parasite killing.Be used for the marginal blepharitis eye, cellulitis, hemorrhoid malignant boil, sore throat, stubborn dermatitis etc.;
5, Pyritum: be sulfide-based mineral yellow iron mine family pyrite.
Nature and flavor: hot, flat.Return Liver Channel.
Performance characteristics: dissipating blood stasis, synthetism, pain relieving.Be used for treating swelling and pain by traumatic injury, the muscles and bones folding is hindered.
6, Radix Arnebiae (Radix Lithospermi): be the dry root of comfrey lithospermum euchromum Royle, Radix Arnebiae (Radix Lithospermi) or arnebia guttata Bunge.
Nature and flavor: sweet, one-tenth, cold.GUIXIN, Liver Channel.
Performance characteristics: removing heat from blood, invigorate blood circulation the detoxifcation rash.Be used for heat in blood poison Sheng, skin infection, eczema, burn due to hot liquid or fire.
7, Cinnabaris: be sulfide-based mineral cinnabar family cinnabar, main Containing Sulfur hydrargyrum.
Nature and flavor: sweet, be slightly cold, poisonous.The GUIXIN warp.
Performance characteristics: it is relieving convulsion to clear away heart-fire, the detoxifcation of calming the nerves.Be used for palpitation and being susceptible to fright, insomnia and dreamful sleep, aphtha, sore throat, skin infection swells and ache.
8, Borneolum Syntheticum: this product is water white transparency or the crisp crystallization of white translucent lamellar; Gas delicate fragrance, acrid in the mouth, cold: tool volatility.
Nature and flavor: hot, bitter, be slightly cold.GUIXIN, spleen, lung meridian.
Performance characteristics: it is eye-catching to have one's ideas straightened out, clearing away heat to alleviate pain.Be used for the calentura coma, convulsion is fainted, the apoplexy syncope due to accumulation of phlegm, external energy reducing swelling and alleviating pain, and erosion prevention and muscle growing swells and ache conjunctival congestion, aphtha, laryngopharynx swelling and pain to control skin infection.
9, catechu: be the peeling branch of leguminous plant catechu, dried dry soft extracts.
Nature and flavor: bitter, puckery, be slightly cold.Return lung meridian.
Performance characteristics: removing dampness promoting tissue regeneration and ulcer healing.Be used for ulcer being unable to heal, eczema, aphtha, traumatic pain, traumatic hemorrhage.
10, Moschus: be the dry secretions in animal in deer family woods Moschus moschiferous, horse Moschus moschiferous, the ripe male body note capsule of former Moschus moschiferous.
Nature and flavor: hot, warm.GUIXIN, spleen channel.
Performance characteristics: the refreshment of having one's ideas straightened out, blood circulation promoting and dispersing pathogen accumulation, pain relieving is hastened parturition.Be used for that epidemic febrile disease heat attacking the pericardium coma convulsion is fainted, apoplexy syncope due to accumulation of phlegm, sore swollen toxin, mass in the abdomen, amenorrhea, trusted subordinate's sudden pain, all pains of traumatic injury and arthromyodynia.
11, silver sulfadiazine: this product is the crystalline powder of white or off-white color; Meeting light meets hot perishable.
Performance characteristics: sulfonamides.Have inhibiting bacteria and diminishing inflammation and convergence, analgesic effect.The burn wound that is used for bacillus pyocyaneus or other bacterial infections.
12, zinc oxide: this product is a fine-powder for the no grittiness of white or atomic yellow-white; Odorless; Absorbing carbon dioxide slowly in air.
Performance characteristics: astringency.Have the convergence wound, protect mucocutaneous, as to promote wound healing effect.Be used for dermatitis and eczema.
This invention is a utilization current clinical medicine knowledge, excavates motherland's medical heritage and the Chinese medicine and western medicine compound formulation based on Chinese medicine developed.It has antiinflammatory, pain relieving, stop blooding, invigorate blood circulation, removing the necrotic tissue and promoting granulation, to hold back skin ulcer antipruritic, promotes all kinds of wound healing effects, is mainly used in: 1, the various fresh and firearm wounds that infect in the war; 2, the wound of the fresh and infection of various general traumatic injury; 3, the body surface chronic and refractory ulcer due to varicose veins of the lower extremity and other reason; 4, the various fresh and burns that infect, scald wound; 5, the eczema wound of concurrent infection.
Its characteristics are: 1, applied range, on indication, surpass in domestic and international any external at present, western drug, it not only has the good curing effect to various trauma wounds fresh and that infect, and burn, eczema infection and lower limb chronic and refractory ulcer are equally also had clinical specially good effect.
2, drug quality is stable, and is evident in efficacy, in the present external, Western medicine can not compare.3, have broad-spectrum antibacterial action, short treating period, instant effect, side effect is little, has carried keeping, and is easy to use.
The present invention usually adopts existing common process technology, and the process route hierarchy of operation is clear, the selection tunnel, and concocted specification, production technology is feasible, and drug quality guarantees, and is easy to use, welcome by sufferer deeply.
The present invention is through Shaanxi Province medicine inspecting institute pharmacological research and done pharmacology, toxicological test:
Pharmacological action:
One, antibacterial action: experiment showed, that external of the present invention has broad-spectrum antibacterial action, its 50% concentration all has more than the moderate responsive to Bacillus proteus, bacillus pyocyaneus, staphylococcus aureus, escherichia coli, group B streptococcus, broad-spectrum antibacterial action is arranged.
Two, hemostasis, antiinflammatory, promoting muscle growth functions:
Experiment showed, that the present invention obviously is better than sulfanilamide crystal to local hemostasis, antiinflammatory, convergence, granulation promoting, the promotion healing effect of skin wounds and liver wound.
Toxicological experiment:
1, local toxicological experiment:
The present invention is atomic through the skin absorbtivity, and the possibility of no accumulate poisoning is No Poison.
2, skin irritation test:
Smear observation through DABAI ear rabbit, surface does not all have redness, skin irritation symptom.
3, hypersensitive test:
Through experimental observation, nose does not all appear scratching in Cavia porcellus, sneeze, perpendicular hair, tic, dyspnea, gatism, anaphylaxiss such as shock death.
4, acute toxicity test L
D50Be 16.41/kg, be nontoxic level medicine;
Prove by above pharmacology, toxicity research, this invention to various traumatic wounds infect, the eczema wound of body surface chronic and refractory ulcer, concurrent infection has broad-spectrum antiseptic, antiinflammatory, pain relieving, hemostasis, removing the necrotic tissue and promoting granulation, the effect of convergence wound, clinical effectiveness is remarkable.
In sum, prescription of the present invention meets the modern medicine clinical research, identify through authoritative department, its prescription be feasible, that this invention research reaches domestic similar drug research clinical effectiveness is leading, filled up the technology application that compound Chinese medicinal preparation is learned at surgical wound, its clinical practice should be widelyd popularize.
For further showing the clinical practice of the present invention, enumerate some clinical observation data and cases below to all kinds of traumatic infections:
The present invention is since 1976 begin development, last 10 years, by formally carrying out clinical trial year May in April, 85 to 86, specify the attached Second Academy of Xian Medical Univ to test 106 examples by Shaanxi Province Department of Public Health one year over, 100 examples are tested by The People's Hospital, Shaanxi Province Affiliated Hospital of the academy of traditional Chinese medicine 56 examples, second the People's Hospital, Xi'an, 79 examples, Xi'an four-player people hospital 59 examples, Shaanxi Province hospital of geology bureau 60 examples.And test group cures lower limb chronic and refractory ulcer 53 examples in Xi-an City Central Hospital, and accumulative total is treated 513 examples, and all wounds have all obtained healing.Wherein: 1, lower limb chronic and refractory ulcer 148 examples, invalid through traditional Chinese and western medicine mean treatment 408 days, through mean treatment of the present invention in the time of 50 days cure rate reach 94%, surplus 9 philtrums, 2 people cured in 52 days, cured in 3 people 70-75 days, and the 4 routine courses of disease surpassed 9 years patient's healing times above 100 days.2, nonspecific infection wound 241 examples, when the present invention treated 10 days, cure rate reached 92%.The 19 people's healing times of surplusing surpass 10 days, reach 28 days most.Fresh nothing infects wound 124 examples, and the silly healing person of knot reaches 69% through changing dressings once promptly.
One, infect the class wound:
389 routine infected wounds comprise lower limb intractable ulcer 148 examples, general trauma infection contamination wound 178 examples, and II ° of burn infection 5 examples, eczema infects 9 examples.The wound that whole infected wounds promptly infect through above-mentioned hospital regular treatment after injured immediately is not (when infecting after injured, in grind institute and begin Jindao San, infect the back SHENGJISAN, matter acid is planted with corruption earlier by Xian Medical Univ, infect the back ethacridine, other hospitals use sulfanilamide crystal earlier, use ethacridine after the infection instead).Do not use the present invention's treatment instead when having positive effect through the said medicine regular treatment long period again behind such wound infection, the result is as follows:
1, lower limb chronic and refractory ulcer 148 examples, average area 12.5cm
2All use SHENGJISAN respectively through each institute, ethacridine, humic acids and infrared ray, laser physical therapy, average 408 days of clothes western medicines in treatment, and there is not positive effect, after using the present invention's treatment instead, cured in average 21.2 days, learn by statistics and handle, curative effect of the present invention has been compared highly significant with other drug, P＜0.0005.(this group patient has 90%, simultaneously with varicose veins of the lower extremity in various degree).See Table 1
2, general trauma infection contamination 241 examples comprise general trauma infection contamination 178 examples, II ° of burn infection 54 example and eczema concurrent infection 9 examples, and average area is 11.9cm
2, on average still do not have and be clearly better through ethacridine, SHENGJISAN treatment in 16.7 days purulent secretion and wound, use the present invention instead after, on average cured through 5.6 days.See Table 1
389 routine infected wound different pharmaceutical efficacy result tables
| Wound type | The example number | Average area cm 2 | Use SHENGJISAN, ethacridine treatment time (my god) | Effect | Use instead healing time of the present invention (my god) |
| General trauma infection contamination | 241 | ?11.9 | ?16.7 | No positive effect | 5.6 |
| The obstinate ulcer of lower limb | 148 | ?12.5 | ?408 | No positive effect | 21.2 |
Two, fresh wound:
Totally 124 examples, wherein general wound 104 examples, average area 3.9cm
2,, cured in average 3.6 days with the present invention's treatment.II ° of burn 19 examples, average area 7.8cm
2, with the present invention's treatment, healing in average 3.8 days.Eczema 1 example, area 4cm
2, cured in 12 days.None routine suppurative infection among the 124 routine patients has 69% patient through the wound of once the changing dressings healing of promptly forming a scab.After using the present invention, wound oozes out blood stops pain relief.Treatment time of the present invention is compared with previously stipulating healing time (1-2), learn by statistics and handle P＜0.0005.See Table 2 (the statistics subordinate list slightly)
The fresh trauma wounds curative effect table of the present invention's 124 examples
| Wound type | The example number | Average area cm 2 | Healing time (my god) | The past healing time (my god) |
| General wound | 104 | ?3.9 | ?3.6 | ?7-14 |
| II ° of burn | 19 | ?7.8 | ?3.8 | ?14 |
| Eczema | 1 | ?4 | ?12 | ?14 |
The result sums up:
1, indication scope of the present invention is wide, this be present clinical external used medicine can't be obtained.Chinese medicine preparation Jindao San, Anisodus carniolicoides C.Y.Wu et C.Chen etc. are mainly controlled fresh wound at present.SHENGJISAN, Hylotelephium erythrostictum (Miq.) H.Ohba SHENGJISAN etc. is mainly controlled the suppurative infection wound, to fresh wound forbidding.And main treatment burn such as burn powder though stronger antiinflammatory convergence promoting muscle growth functions is arranged, does not have hemostasia effect, can not be used for fresh bleeding wounds, though the Calamina preparation is effective to eczema, to fresh hemorrhage, wounds such as burn can not be used, a present invention then medicine uses more, both can treat fresh wound, hemostasis, antiinflammatory, pain relieving, promoting healing effect were arranged, can be used for various suppurative infection wounds again, comprise chronic intractable low limbs ulcer, also can treat burn and add eczema.And curative effect is higher than present Chinese and Western medicine for external use.
2, this medicine is treated fresh wound 124 examples, and none infection is used for various suppurative wounds, and secretions is reduced rapidly, and healing is rapidly and to the significant curative effect of eczema, burn, confirms that further this medicine has anti-inflammatory analgetic, removing the necrotic tissue and promoting granulation, convergence antipruritic, the promoting healing effect.
3, this medicine is treated among the 513 routine patients altogether, and all none example of patient is irritated, uses the no local excitation pain in back and other pair effect.
4, check from clinical blood, trace element zinc is not only not high instead a little less than normal value or be normal value on the low side in the serum, illustrates that this medicine for external use absorbtivity is atomic, from all examined the patient liver, renal function is normal, and drug abuse test confirms that this medicine is nontoxic.
5, this medicine confirms through medicine inspection: broad-spectrum antibacterial action is arranged, and antibacterial effect is higher than Anisodus carniolicoides C.Y.Wu et C.Chen, YUNNAN BAIYAO, and yellow amine crystallization, approaching with SHENGJISAN, and obvious hemostasis, antiinflammatory are arranged. the effect of convergence granulation promoting promoting healing.
6, the keeping of this medicine is easy to use, has 30 routine chronic ulcer patients oneself to be with medicine to go home oneself to spread deposited approximately, and curative effect is also as in the hospitalize result.
7, this medicine has obvious economic results in society, and single is example to cure lower limb chronic and refractory ulcer 148 examples, this 148 routine mean treatment 408 days, and surpass 1 year the course of treatment, so do not see yet to be clearly better, and uses this medicine instead and promptly cured in 21.2 days.Shorten nearly 20 times the course of treatment.It has not only reduced misery, for national individual has saved spending, also for going the patient of varicose great saphenous vein excision, provides the chance of surgical radical treatment.
8, this medicine is to use present-day medical knowledge, in conjunction with the Chinese medicine theory, and the compound formulation of mating part Western medicine, from whole results, meet original design requirement, obvious use value is arranged, and can in all kinds of hospitals or by the patient, directly use, special application approval is identified, and clinical practice.
Case one:
So-and-so, the woman, 68 years old, the retired cadre lived king of medicine hole, Xi'an;
Left lower extremity varicosis merges ulcer 15 years, once in various big hospital injection of antibiotics such as Affiliated Hospital of Xian Medical Univ, Affiliated Hospital of The Fourth Military Medical University, Xi'an second hospital, No. 4 Hospital of Xi-an City, Xi-an City Central Hospital, Red Cross Hospitals, Chinese medicine and western medicine for oral administration and the external application of placenta tissue slurry Chinese medicine and western medicine, multiple treatment such as physical therapy, laser, and in Shenyang district hospital of army, the Xi'an Second Academy, Xian Medical Univ and worker's hospital are in hospital four times, do not heal over 15 years always.When accepting the treatment of this medicine, hinder face central part granulation and be and homogenize, fibrous tissue shape milky is hardened, and presss from both sides, touches no hemorrhage, and secretions is yellow pus, hinders face area 8 * 7cm
2, the wound circumference tissue is the dipping shape, the point-like erosion, and the wound circumference Keratoderma, gloss is purple darkly, the about 20 * 14cm of area
2, treat healing in four months through the present invention.
Case two:
Patient Liao, man, 19 years old, Yuncheng, Shanxi people, peasant;
After half a year, the cause fever was taken sulfa drugs, the outside is risen and is dispersed in scleroma in the both legs, continuous left leg inboard, the inboard ulceration of right leg, treat repeatedly in the local hospital of Yuncheng, Shanxi and not heal, come the 5th the People's Hospital, Xi'an, city center hospital, change dressings with mycillin anti-inflammatory treatment and Chinese medicine Hylotelephium erythrostictum (Miq.) H.Ohba SHENGJISAN, Fu Suer, ethacridine etc. invalid.
Have a medical check-up when accepting this medicine treatment, the varicose of both legs vein moderate, wound circumference is the reddish violet inflammatory reaction, and dipping property skin erosion is arranged, wound left side 6 * 9cm
2, right 5 * 5cm
2, the obvious swelling in two ankles and instep uses this medicine treatment to cure in 41 days through simple.
Case three:
Censure certain, the man, 27 years old, Gaoling County, Shaanxi Province elm Chu Xiang pacified people from village;
Year surplus the trouble left leg varicosis ten, can not cure over 5 years always, when accepting this medicine treatment, the other 5 * 1cm of ulcer surface integration
2, 4 * 2cm
2, hinder dark about 1 centimetre of face, granulation is the edema shape, and surrounding tissue is a bit rotten to the corn, all purple, keratinization, gloss darkly of skin around the wound.Carry medicine by the patient and go home to change dressings, cured in 50 days.
Case four:
Patient Huang, the man, 33 years old, the workman was because of burn causes the left hand third finger and middle finger has 5 * 3cm
2, wound surface, (II ° of burn) are behind twice this medicine of usefulness, and patient's feels pain disappears, wound surface incrustation healing.
Case five:
Relative, man, 59 years old, the workman was because of burning to right lower extremity shank suppuration diabrosis, wound surface 4 * 2.6cm
2, once to change dressings half a year with ethacridine, unsatisfactory curative effect after the treatment of this medicine, is changed dressings four times, (next day once), recovery from illness.
Embodiment one:
Chinese medicine of the present invention is made by following materials of weight proportions:
Calamina 580g Sanguis Draxonis 22g
System Aerugo 12g Olibanum (processed) 20g
Pyritum (calcined) 20g Radix Arnebiae (Radix Lithospermi) 30g
Cinnabaris 25g silver sulfadiazine 40g
Borneolum Syntheticum 30g zinc oxide 200g
Catechu 20g Moschus 1g
Above-mentioned dosage form is that the processing step of preparation method of external pulvis is as follows:
(1), Moschus, Borneolum Syntheticum put be ground into fine powder in the mortar, by No. six sieves, Cinnabaris water flies porphyrize or is ground into superfine powder, and is standby;
(2), with Calamina, Pyritum, system Aerugo, oxide powder and zinc be broken into impalpable powder, by No. eight the sieve, standby;
(3), all the other five kinds of Chinese medicine such as catechu are ground into fine powder, by No. five sieves, step (1), (2) bottoming chromatography are being added Cinnabaris, behind the mixing, by the equivalent incremental method Moschus, Borneolum Syntheticum two flavor medicines are being mixed with above-mentioned thin medicated powder again, cross 100 mesh sieves, in the mixing apparatus container, stirred 40 minutes, full and uniform after, take out, weighing is packed promptly by description 1g, 3g, 5g, 100g.
Embodiment two:
Chinese medicine of the present invention is made by following materials of weight proportions:
Calamina 560g Sanguis Draxonis 18g
System Aerugo 8g Olibanum (processed) 10g
Pyritum (calcined) 10g Radix Arnebiae (Radix Lithospermi) 20g
Cinnabaris 15g silver sulfadiazine 30g
Borneolum Syntheticum 20g zinc oxide 150g
Catechu 10g Moschus 0.5g
The processing step of its preparation method is identical with embodiment one.
Embodiment three:
Calamina 600g Sanguis Draxonis 24g
System Aerugo 14g Olibanum (processed) 30g
Pyritum (calcined) 30g Radix Arnebiae (Radix Lithospermi) 40g
Cinnabaris 35g silver sulfadiazine 50g
Borneolum Syntheticum 40g zinc oxide 250g
Catechu 30g Moschus 3g
The processing step of its preparation method is identical with embodiment one.
Claims (3)
1, a kind of medicine for the treatment of the wound sore healing, it is characterized in that: described Chinese medicine is made by following materials of weight proportions:
Calamina 560-600 part Sanguis Draxonis 18-24 part
System Aerugo 8-14 part Olibanum (processed) 10-30 part
Pyritum (calcined) 10-30 part Radix Arnebiae (Radix Lithospermi) 20-40 part
Cinnabaris 15-35 part silver sulfadiazine 30-50 part
Borneolum Syntheticum 20-40 part zinc oxide 150-250 part
Catechu 10-30 part Moschus 0.5-3 part.
2, a kind of medicine for the treatment of the wound sore healing according to claim 1, it is characterized in that: described Chinese medicine is made by following materials of weight proportions:
22 parts of 580 parts of Sanguis Draxonis of Calamina
20 parts of 12 parts of Olibanum (processed)s of system Aerugo
30 parts of 20 portions of Radix Arnebiae (Radix Lithospermi)s of Pyritum (calcined)
40 parts of 25 parts of silver sulfadiazine of Cinnabaris
200 parts of 30 parts of zinc oxide of Borneolum Syntheticum
1 part in 20 parts of Moschus of catechu.
3, a kind of medicine for the treatment of the wound sore healing according to claim 1 and 2 is characterized in that: described dosage form is that the processing step of preparation method of external pulvis is as follows:
(1), Moschus, Borneolum Syntheticum put be ground into fine powder in the mortar, by No. six sieves, Cinnabaris water flies porphyrize or is ground into superfine powder, and is standby;
(2), with Calamina, Pyritum, system Aerugo, oxide powder and zinc be broken into impalpable powder, by No. eight the sieve, standby;
(3), catechu, Sanguis Draxonis, Olibanum (processed), Radix Arnebiae (Radix Lithospermi), silver sulfadiazine five kinds of Chinese medicine are ground into fine powder, by No. five sieves, step (1), (2) bottoming chromatography are being added Cinnabaris, behind the mixing, by the equivalent incremental method Moschus, Borneolum Syntheticum two flavor medicines are being mixed with above-mentioned thin medicated powder again, cross 100 mesh sieves, in the mixing apparatus container, stirred 40 minutes, full and uniform after, take out, weighing, by the description packing promptly.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200310105917 CN1259087C (en) | 2003-11-13 | 2003-11-13 | Medicine for treating trauma and sores and its preparing process |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200310105917 CN1259087C (en) | 2003-11-13 | 2003-11-13 | Medicine for treating trauma and sores and its preparing process |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1544003A CN1544003A (en) | 2004-11-10 |
| CN1259087C true CN1259087C (en) | 2006-06-14 |
Family
ID=34333926
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200310105917 Expired - Lifetime CN1259087C (en) | 2003-11-13 | 2003-11-13 | Medicine for treating trauma and sores and its preparing process |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1259087C (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102178810B (en) * | 2011-04-28 | 2012-11-21 | 上海市中医医院 | Chinese medicinal paste film for treating skin ulcer and preparation method thereof |
| CN103202981B (en) * | 2013-05-08 | 2015-07-01 | 山东新希望六和集团有限公司 | Medicine for treating trauma infectious diseases of animals |
| CN105168936A (en) * | 2015-10-13 | 2015-12-23 | 鞠进英 | Nanometer wound-healing nursing gel and preparation method thereof |
| CN105616715A (en) * | 2016-01-20 | 2016-06-01 | 信阳农林学院 | Medicine for treating animal trauma and preparation method thereof |
| CN110384717A (en) * | 2019-08-09 | 2019-10-29 | 盖素军 | It is a kind of to treat dermopathic externally applied Chinese medicine and preparation method thereof |
| CN114404532A (en) * | 2022-03-22 | 2022-04-29 | 刘任兴 | Traditional Chinese medicine preparation for treating skin trauma and preparation method thereof |
-
2003
- 2003-11-13 CN CN 200310105917 patent/CN1259087C/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| CN1544003A (en) | 2004-11-10 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN100350951C (en) | External-applied medicine for treating burn, valnus and local tumor inflammation | |
| CN101703651B (en) | Medicament for treating diabetic gangrene | |
| CN1259087C (en) | Medicine for treating trauma and sores and its preparing process | |
| WO2012100754A1 (en) | Chinese medicine composition for treating stab wounds, burns, and various traumas | |
| CN102579709B (en) | Scar preventing and removing burn oil and preparation method thereof | |
| CN104887958B (en) | Treat Chinese medicine preparation of Shelled Turtle Trionyx Sinensis enteritis and preparation method thereof | |
| CN1286489C (en) | Scarless burn and scald treatment liquid and its preparation method | |
| CN1279952C (en) | Medicine for treating burn and scald | |
| CN104306889B (en) | A kind of Chinese medicine powder for the treatment of radiation dermatitis and preparation method thereof | |
| CN102670863B (en) | Compound propolis composition for treating acariasis of domestic animal and preparation method thereof | |
| CN104435566A (en) | External medicine for treating animal wound and preparation method of external medicine | |
| CN1094765C (en) | External-use burn ointment | |
| CN104606340A (en) | Purely natural traditional Chinese medicine repair skin and tissue cream | |
| CN103041011B (en) | Oral drug for treating gosling candidiasis | |
| CN103585374B (en) | A kind of ointment treating tinea unguium | |
| CN102552362A (en) | Medicament for treating tinea | |
| CN101810703A (en) | Chinese medicament for treating burns and scalds | |
| CN101716191A (en) | Externally applied traditional Chinese medicine composition for treating bedsores | |
| CN101513458B (en) | Traditional Chinese medicine composition for treating scalds and preparation method thereof | |
| CN107019788A (en) | It is a kind of to treat Chinese medicine composition of tinea pedis and preparation method thereof | |
| CN106420815A (en) | Pharmaceutical composition and preparation method and application thereof | |
| CN1850224A (en) | Medicine for treating scald and burn and preparing method | |
| CN104523910A (en) | Traditional Chinese medicine oral liquid for treating epifolliculitis | |
| CN101822699B (en) | Traditional Chinese medicine for treating psoriasis and preparation method thereof | |
| CN103211956B (en) | External poultice for treating burn |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CX01 | Expiry of patent term |
Granted publication date: 20060614 |
|
| CX01 | Expiry of patent term |