CN114404532A - Traditional Chinese medicine preparation for treating skin trauma and preparation method thereof - Google Patents

Traditional Chinese medicine preparation for treating skin trauma and preparation method thereof Download PDF

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CN114404532A
CN114404532A CN202210283817.9A CN202210283817A CN114404532A CN 114404532 A CN114404532 A CN 114404532A CN 202210283817 A CN202210283817 A CN 202210283817A CN 114404532 A CN114404532 A CN 114404532A
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parts
powder
blood
calamine
dragon
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刘任兴
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Abstract

The application provides a traditional Chinese medicine preparation for treating skin trauma and a preparation method thereof, and relates to the technical field of traditional Chinese medicines. A traditional Chinese medicine preparation for treating skin trauma comprises, by weight, 150 parts of gypsum, 25-75 parts of pearl, 25-75 parts of calamine, 5-15 parts of keel, 5-15 parts of cinnabar, 5-15 parts of borneol, 5-15 parts of dragon's blood, 5-15 parts of calomel, 900 parts of vaseline, 1100 parts of corn oil and 350 parts of sand. The borneol is used for clearing liver heat (blood stasis and heat transformation cause liver depression), the dragon's bone is used for entering liver meridian, calming liver and suppressing yang, the dragon's blood and the dragon's bone are used for promoting blood circulation and nourishing tendons and vessels, the dragon's blood, the cinnabar and the gypsum are used for stopping bleeding and removing blood stasis, the calamine, the calomel, the dragon's blood and the gypsum are used for promoting granulation and healing sore, and the vaseline and the corn oil can keep an affected part moist and a relatively closed environment, so that recovery of the affected part can be facilitated.

Description

Traditional Chinese medicine preparation for treating skin trauma and preparation method thereof
Technical Field
The application relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine preparation for treating skin trauma and a preparation method thereof.
Background
The trauma is of various types, and generally comprises incised wound, scald, abrasion, burn and the like, which can seriously affect the life, work and study of patients, cause local skin and muscle red swelling, pain, blisters and necrosis, and seriously cause systemic changes such as combined infection, shock and the like. The mild patient affects the normal work and life, and the severe patient suffers from the disease after the disease is left, which causes great pain to the patient. According to the existing traditional medicine and method for wound treatment and recovery, the problems of slow wound recovery, intolerable long-term pain, easy infection and the like of patients generally exist.
The operation wound, trauma and burn act on the human body as a physical injury factor, the organism can generate a series of pathological changes which are mainly manifested as blood stasis blockage, the mechanism is that external force acts on the organism, blood vessels are damaged, blood flows out of the blood vessels, and is stopped in the gaps of viscera, muscles and skin to become blood stasis away from the channels; blood stasis caused after injury can lead to vascularization, increase peripheral resistance, increase of various components in blood such as lipid, fibrinogen and the like, increase of blood viscosity, reduction of cell surface charge, reduction of deformability and the like, decrease of arterial oxygen output, finally cause arteriolar spasm and insufficient local tissue blood flow. Because of slow blood flow, the erythrocyte aggregation is increased, the deformability is reduced, and the erythrocyte can not enter the capillary, so that the microcirculation is dysfunctional and the local oxygen supply is insufficient. The formation of blood stasis can affect the normal healing of the wound.
Modern pharmacology and clinical research show that the blood circulation promoting and blood stasis removing medicine can improve microcirculation, relax blood vessels, increase the perfusion amount of blood flow of tissues and organs and reduce vascular resistance; improving blood rheological property, inhibiting platelet aggregation; increase the permeability of capillary vessels, improve the function of a reticuloendothelial system and promote the healing of wounds. However, a preparation with good curative effect and short treatment course for treating skin trauma is still lacked in the market at present.
Content of application
The application aims to provide the traditional Chinese medicine preparation for treating the skin trauma, and the traditional Chinese medicine preparation for treating the skin trauma has the advantages of good curative effect and short treatment course.
Another objective of the present application is to provide a method for preparing a Chinese medicinal preparation for treating skin trauma, so as to obtain the Chinese medicinal preparation.
The technical problem to be solved by the application is solved by adopting the following technical scheme.
On one hand, the embodiment of the application provides a traditional Chinese medicine preparation for treating skin trauma, which comprises, by weight, 150-250 parts of gypsum, 25-75 parts of pearl, 25-75 parts of calamine, 5-15 parts of keel, 5-15 parts of cinnabar, 5-15 parts of borneol, 5-15 parts of dragon's blood, 5-15 parts of calomel, 900-1100 parts of vaseline and 350 parts of corn oil.
On the other hand, the embodiment of the application provides a preparation method of a traditional Chinese medicine preparation for treating skin trauma, which comprises the following steps:
crushing gypsum, heating in a smokeless furnace, and calcining to be loose to obtain calcined gypsum;
heating Margarita until detonation stops, taking out, cooling, grinding into powder, adding water, grinding, adding water, stirring, decanting the suspension, standing, collecting precipitate, and drying to obtain Margarita powder;
heating calamine to be red, taking out and soaking in water, stirring, taking an upper layer suspension, and drying to obtain calamine powder;
crushing Os Draconis, heating to red, taking out, cooling, and crushing into powder to obtain Os Draconis powder;
crushing cinnabar into powder, pouring the powder into water, stirring, taking the upper suspension, and drying to obtain cinnabar powder;
respectively crushing the other raw materials except the vaseline and the corn oil into powder;
mixing vaseline and corn oil, heating to boil, adding calcined gypsum, pearl powder, calamine powder, Os Draconis powder and cinnabar powder, stirring, slowly cooling, adding the rest raw materials, and stirring to obtain the final product.
Compared with the prior art, the embodiment of the application has at least the following advantages or beneficial effects:
the inventor of the present application believes that trauma is closely related to qi, blood, lung and viscera, and specifically, the "main body essentials" means that when the limbs are damaged, qi and blood are damaged inside, ying and wei are not consistent, and zang-fu organs are not harmonious, so that the inventor can use any manipulation to treat deficiency and excess to perform supplementary and purgative surgery. The Chinese patent medicine is recorded, but the body surface trauma inevitably destroys blood, the liver stores blood, and the insufficiency of the liver blood also affects the human body to loose and dredge, so that the muscles and the channels are not maintained, and the affected part inevitably forms blood stasis to cause pain at the affected part.
Based on the above, the inventor uses borneol to clear liver heat (blood stasis and heat transformation cause liver depression), uses dragon's bone to enter liver meridian, calms liver and subdues yang, uses dragon's blood and dragon's bone to promote blood circulation, holds and nourishes tendons and vessels, uses dragon's blood, cinnabar and gypsum to stop bleeding and remove blood stasis, and uses calamine, calomel, dragon's blood and gypsum to promote tissue regeneration and heal wound. The vaseline and the corn oil can keep the affected part moist and a relatively closed environment, and can be beneficial to the recovery of the affected part. The medicines have the combined action to promote the recovery of skin trauma, especially have the prominent effect on old injuries, and also have obvious effects on eczema, fester, burn, diabetic foot and postoperative repair.
The inventor of the application can promote the drug effect after processing gypsum, pearl, calamine, keel and cinnabar, can ensure that the purity of the medicinal materials is enough, and then adds the medicinal materials into vaseline to promote the drug effect to be synergistic under the heating state, so that the ointment is good in effect.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present application clearer, the technical solutions of the embodiments of the present application will be clearly and completely described below. The examples, in which specific conditions are not specified, were conducted under conventional conditions or conditions recommended by the manufacturer. The reagents or instruments used are not indicated by the manufacturer, and are all conventional products available commercially.
It should be noted that the embodiments and features of the embodiments in the present application may be combined with each other without conflict. The present application will be described in detail below with reference to specific examples.
Gypsum: sweet, pungent, astringent and cold in nature; it enters lung and stomach meridians. Astringe dampness, promote tissue regeneration, heal wound and stop bleeding. It is used externally to treat ulcer, eczema, scald, traumatic hemorrhage, etc.
Pearl: sweet, salty and cold in nature; it enters heart and liver meridians. Tranquilization and arresting convulsion, improving eyesight and removing nebula, detoxicating and promoting granulation. Mainly used for treating uneasiness, palpitation, insomnia, dreaminess and amnesia; acute or chronic convulsions due to high fever, dysphoria, coma and convulsion, epilepsy and convulsion; blood-shot eyes, nebula and blurred vision; sores and abscess, chronic ulcer without healing; nocturnal emission, spermatorrhea, whitish and turbid urine; skin stains; traumatic injury, incised wound; deafness due to kidney deficiency, dysphoria with feverish sensation in the chest, palms and soles, night sweat; spleen deficiency with accumulated heat, abdominal fullness and distention, adverse flow of qi and vomiting.
Calamine: sweet in taste and neutral in nature; it enters liver, spleen and lung meridians. Improving vision, removing nebula, astringing dampness, relieving itching, healing sore and promoting granulation. The main functions are improving eyesight, removing nebula, astringing dampness, relieving itching, healing sore and promoting granulation.
Keel: sweet and astringent taste and mild nature; it enters heart, liver and kidney meridians. Induce sedation and tranquilization, pacify liver and subdue yang, astringe and induce astringency. It can be used for treating palpitation, insomnia, amnesia, epilepsy, mania, dizziness, blurred vision, spontaneous perspiration, night sweat, spermatorrhea, enuresis, metrorrhagia, leukorrhagia, chronic diarrhea, chronic dysentery, ulcer, and eczema.
Cinnabar: sweet in taste and slightly cold in nature; it enters heart meridian. Clear heart fire, relieve convulsion, induce tranquilization and remove toxicity. It can be used for treating palpitation, insomnia, convulsion, epilepsy, pyocutaneous disease, toxic swelling, sore throat, and aphtha of the mouth and tongue.
Borneol: pungent and bitter in flavor and slightly cold in nature; it enters heart and spleen meridians. Induce resuscitation and refresh mind, clear heat and alleviate pain. It can be used for treating block syndrome manifested by unconsciousness, conjunctival congestion, swelling and pain, sore throat, aphtha, sore and ulcer, unhealed sore and ulcer, and scald due to hot water and fire.
Dragon's blood: sweet, salty and neutral in nature; it enters liver meridian. Promoting blood circulation, relieving pain, removing blood stasis, stopping bleeding, healing sore, and promoting granulation. It can be used for treating traumatic injury, blood stasis, pain of heart and abdomen, traumatic hemorrhage, and unhealed skin and external diseases.
Calomel: pungent and cold; is toxic; it enters large intestine and small intestine meridians. Externally used for killing parasites, counteracting toxic pathogen and healing sore; it can dispel phlegm and remove food retention, dispel water and relieve constipation. The external treatment is used for scabies, stubborn tinea, ecthyma, syphilis, pyocutaneous disease and eczema; it is indicated for accumulation of phlegm and saliva, edema and distention, and constipation by oral administration.
Corn oil: lowering blood pressure and blood fat. It can be used for treating hypertension, hyperlipidemia, arteriosclerosis, and coronary heart disease.
Cattail pollen: sweet in taste and neutral in nature; it enters liver and pericardium meridians. Stop bleeding, resolve stasis, induce diuresis. It can be used for treating hematemesis, epistaxis, hemoptysis, metrorrhagia, traumatic hemorrhage, amenorrhea, dysmenorrhea, thoracic and abdominal pain, traumatic injury, swelling and pain, and stranguria with bloody urine.
Herba Siphonostegiae: bitter taste and cold nature; enter spleen meridian. Clear heat, cool blood and remove toxicity. It can be used for treating carbuncle, ulcer, toxic swelling, lymphoid tuberculosis, malignant sore, acute conjunctivitis, gonorrhea, and intestinal wind.
And (3) camellia: bitter and pungent taste and cool in nature; it enters liver, lung and large intestine meridians. Cool blood to stop bleeding, dissipate stasis to relieve swelling. Can be used for treating hematemesis, epistaxis, hemoptysis, hematochezia, hemorrhoid, dysentery with red and white discharge, bloody stranguria, metrorrhagia, leukorrhagia, scald, traumatic injury
Green tangerine peel: bitter and pungent taste, warm in nature; it enters liver, gallbladder and stomach meridians. To soothe the liver, break qi, resolve stagnation and resolve stagnation. It can be used for treating syndrome of liver qi stagnation, abdominal pain due to food stagnation, abdominal mass, and lump of chronic malaria.
Penglai Ge: bitter and pungent taste, warm in nature; it enters liver meridian. Dispel wind, dredge collaterals and stop bleeding. It can be used for treating rheumatalgia and traumatic hemorrhage.
Ramie root: sweet taste and cold nature; clear heat and induce diuresis, cool blood and prevent abortion. Can be used for treating common cold, fever, measles, high fever, urinary tract infection, nephritis, edema, pregnant woman abdominal pain, fetal irritability, and threatened abortion; it is used externally to treat traumatic injury, fracture, sore, ulcer and pyogenic infection.
Ru lan: bitter taste and cold nature; it enters heart, liver and large intestine meridians. Clear away heat and toxic material, dissipate blood stasis and relieve pain. Can be used for treating common cold, pharyngalgia, diarrhea, dysentery, swelling, stomach ache, headache, rheumatalgia, and traumatic injury.
Silybum marianum: bitter and cool; it enters liver and gallbladder meridians. Clear heat and remove toxicity, soothe liver and promote bile flow. It can be used for treating damp-heat in liver and gallbladder, hypochondriac pain, and jaundice.
B, yellow flower blood nourishing grass: bland in flavor and cool in nature. Relieving pain, diminishing inflammation, and tonifying blood. Mainly used for treating neuralgia, hypomenorrhea, tinnitus, insufficient breast milk and cold; it is externally used for toothache, sore, furuncle, carbuncle and swelling.
The application provides a traditional Chinese medicine preparation for treating skin trauma, which comprises, by weight, 150 parts of gypsum, 25-75 parts of pearl, 25-75 parts of calamine, 5-15 parts of keel, 5-15 parts of cinnabar, 5-15 parts of borneol, 5-15 parts of dragon's blood, 5-15 parts of calomel, 900 parts of vaseline, 1100 parts of sand-broken materials and 350 parts of corn oil.
The inventor of the present application believes that trauma is closely related to qi, blood, lung and viscera, and specifically, the "main body essentials" means that when the limbs are damaged, qi and blood are damaged inside, ying and wei are not consistent, and zang-fu organs are not harmonious, so that the inventor can use any manipulation to treat deficiency and excess to perform supplementary and purgative surgery. The Chinese patent medicine is recorded, but the body surface trauma inevitably destroys blood, the liver stores blood, and the insufficiency of the liver blood also affects the human body to loose and dredge, so that the muscles and the channels are not maintained, and the affected part inevitably forms blood stasis to cause pain at the affected part.
Based on the above, the inventor uses borneol to clear liver heat (blood stasis and heat transformation cause liver depression), uses dragon's bone to enter liver meridian, calms liver and subdues yang, uses dragon's blood and dragon's bone to promote blood circulation, holds and nourishes tendons and vessels, uses dragon's blood, cinnabar and gypsum to stop bleeding and remove blood stasis, and uses calamine, calomel, dragon's blood and gypsum to promote tissue regeneration and heal wound. The vaseline and the corn oil can keep the affected part moist and a relatively closed environment, and can be beneficial to the recovery of the affected part. The medicines have the combined action to promote the recovery of skin trauma, especially have the prominent effect on old wounds and wounds which can not be healed for a long time, and also have the obvious effect on eczema, fester, burn, diabetic foot and postoperative repair.
In some embodiments of the application, the traditional Chinese medicine preparation comprises, by weight, 230 parts of gypsum 180-.
In some embodiments of the present application, the above traditional Chinese medicine preparation further comprises, by weight, 5-15 parts of pollen typhae, 3-10 parts of herba pteridis multifidae, 3-10 parts of camellia, 2-8 parts of pericarpium citri reticulatae viride, 3-8 parts of pachyrhizua angulatus, 2-5 parts of ramie root, 1-5 parts of radix agaves rubra, 3-8 parts of silybum marianum, and 3-8 parts of limonium aureum.
The inventor considers that skin trauma can cause blood coagulation, air circulation is blood, blood flows through the whole body along with air, the blood coagulation can cause unsmooth air coagulation, the blood coagulation is blocked, blood stasis is aggravated, the affected part can be recovered slowly, and pain of the affected part can be caused.
On the basis, the inventor uses the pericarpium citri reticulatae viride to soothe the liver and break stagnant qi; green tangerine orange peel, camellia, herba physalis, ramie root, cymbidium, silybum marianum, dragon's blood and dragon's bone are used together to clear heat and soothe the liver, relieve liver depression, strengthen hematopoiesis, strengthen the effect of soothing the liver and avoid weakness caused by liver strain; the Ru lan and the camellia are used together with the dragon's blood, the cinnabar and the gypsum to strengthen the effect of removing blood stasis; and the daylily limonium for replenishing blood, the bulrush and the cattail pollen for stopping bleeding. Can be used together with other medicines for treating skin trauma and healing wound.
In some embodiments of the application, the traditional Chinese medicine preparation comprises, by weight, 230 parts of gypsum 180-containing materials, 40-60 parts of pearls, 40-60 parts of calamine, 8-13 parts of dragon bone, 8-13 parts of cinnabar, 8-13 parts of borneol, 8-13 parts of dragon blood, 8-13 parts of calomel, 950-1050 parts of vaseline, 330 parts of corn oil 280-containing materials, 8-12 parts of cattail pollen, 5-8 parts of starwort, 5-8 parts of camellia, 4-6 parts of green tangerine peel, 5-7 parts of cabernet buergerianum, 3-5 parts of ramie root, 2-4 parts of cymbidium, 4-6 parts of silybum marianum and 4-6 parts of limonium aureum.
The application also provides a preparation method of the traditional Chinese medicine preparation for treating skin trauma, which comprises the following steps:
crushing gypsum, heating in a smokeless furnace, and calcining to be loose to obtain calcined gypsum;
heating Margarita until detonation stops, taking out, cooling, grinding into powder, adding water, grinding, adding water, stirring, decanting the suspension, standing, collecting precipitate, and drying to obtain Margarita powder;
heating calamine to be red, taking out and soaking in water, stirring, taking an upper layer suspension, and drying to obtain calamine powder;
crushing Os Draconis, heating to red, taking out, cooling, and crushing into powder to obtain Os Draconis powder;
crushing cinnabar into powder, pouring the powder into water, stirring, taking the upper suspension, and drying to obtain cinnabar powder;
respectively crushing the other raw materials except the vaseline and the corn oil into powder;
mixing vaseline and corn oil, heating to boil, adding calcined gypsum, pearl powder, calamine powder, Os Draconis powder and cinnabar powder, stirring, slowly cooling, adding the rest raw materials, and stirring to obtain the final product.
The inventor of the application can promote the drug effect after processing gypsum, pearl, calamine, keel and cinnabar, can ensure that the purity of the medicinal materials is enough, and then adds the medicinal materials into vaseline to promote the drug effect to be synergistic under the heating state, so that the ointment is good in effect.
In some embodiments of the present application, the pearl is heated at a temperature of 70-90 deg.C.
In some embodiments of the present application, the above-described calamine heating temperature is 95-105 ℃.
In some embodiments of the present application, the keel heating temperature is 95-105 ℃.
In some embodiments of the present application, after the vaseline and corn oil are mixed and heated, the mixture is continuously heated for 3-5min, and then calcined gypsum, pearl powder, calamine powder, dragon bone powder and cinnabar powder are added.
In some embodiments of the present application, the reduced temperature is 35-45 ℃.
The features and properties of the present application are described in further detail below with reference to examples.
Example 1
A preparation method of a traditional Chinese medicine preparation for treating skin trauma comprises the following steps:
raw materials: 150g of gypsum, 25g of pearl, 25g of calamine, 5g of keel, 5g of cinnabar, 5-15g of borneol, 5g of dragon's blood, 5g of calomel, 900g of vaseline and 250g of corn oil.
Crushing gypsum, heating in a smokeless furnace, and calcining to be loose to obtain calcined gypsum;
heating Margarita at 70 deg.C until detonation stops, taking out, cooling, grinding into powder, adding water, grinding, adding water, stirring, decanting the suspension, standing, collecting precipitate, and drying to obtain Margarita powder;
heating calamine to be red at 95 ℃, taking out and soaking in water, stirring, taking out upper layer suspension, and drying to obtain calamine powder;
crushing Os Draconis, heating at 95 deg.C to red, taking out, cooling, and crushing into powder to obtain Os Draconis powder;
crushing cinnabar into powder, pouring the powder into water, stirring, taking the upper suspension, and drying to obtain cinnabar powder;
respectively crushing the other raw materials except the vaseline and the corn oil into powder;
mixing vaseline and corn oil, heating to boil, heating for 3min, adding calcined Gypsum Fibrosum, Margarita powder, Calamina powder, Os Draconis powder and Cinnabaris powder, stirring, slowly cooling to 35 deg.C, adding the rest raw materials, and stirring to obtain the final product.
Example 2
A preparation method of a traditional Chinese medicine preparation for treating skin trauma comprises the following steps:
raw materials: 180g of gypsum, 40g of pearl, 40g of calamine, 8g of keel, 8g of cinnabar, 8g of borneol, 8g of dragon's blood, 8g of calomel, 950g of vaseline and 280g of corn oil.
Crushing gypsum, heating in a smokeless furnace, and calcining to be loose to obtain calcined gypsum;
heating Margarita at 75 deg.C until detonation stops, taking out, cooling, grinding into powder, adding water, grinding, adding water, stirring, decanting the suspension, standing, collecting precipitate, and drying to obtain Margarita powder;
heating calamine to be red thoroughly at 100 ℃, taking out and soaking in water, stirring, taking out upper layer suspension, and drying to obtain calamine powder;
crushing Os Draconis, heating at 100 deg.C to red, taking out, cooling, and crushing into powder to obtain Os Draconis powder;
crushing cinnabar into powder, pouring the powder into water, stirring, taking the upper suspension, and drying to obtain cinnabar powder;
respectively crushing the other raw materials except the vaseline and the corn oil into powder;
mixing vaseline and corn oil, heating to boil, heating for 4min, adding calcined Gypsum Fibrosum, Margarita powder, Calamina powder, Os Draconis powder and Cinnabaris powder, stirring, slowly cooling to 38 deg.C, adding the rest raw materials, and stirring to obtain the final product.
Example 3
A preparation method of a traditional Chinese medicine preparation for treating skin trauma comprises the following steps:
raw materials: 200g of gypsum, 50g of pearl, 50g of calamine, 10g of keel, 10g of cinnabar, 10g of borneol, 10g of dragon's blood, 10g of calomel, 1000g of vaseline and 300g of corn oil.
Crushing gypsum, heating in a smokeless furnace, and calcining to be loose to obtain calcined gypsum;
heating Margarita at 80 deg.C until detonation stops, taking out, cooling, grinding into powder, adding water, grinding, adding water, stirring, decanting the suspension, standing, collecting precipitate, and drying to obtain Margarita powder;
heating calamine to be red thoroughly at 100 ℃, taking out and soaking in water, stirring, taking out upper layer suspension, and drying to obtain calamine powder;
crushing Os Draconis, heating at 100 deg.C to red, taking out, cooling, and crushing into powder to obtain Os Draconis powder;
crushing cinnabar into powder, pouring the powder into water, stirring, taking the upper suspension, and drying to obtain cinnabar powder;
respectively crushing the other raw materials except the vaseline and the corn oil into powder;
mixing vaseline and corn oil, heating to boil, heating for 4min, adding calcined Gypsum Fibrosum, Margarita powder, Calamina powder, Os Draconis powder and Cinnabaris powder, stirring, slowly cooling to 40 deg.C, adding the rest raw materials, and stirring to obtain the final product.
Example 4
A preparation method of a traditional Chinese medicine preparation for treating skin trauma comprises the following steps:
raw materials: 230g of gypsum, 60g of pearl, 60g of calamine, 13g of keel, 13g of cinnabar, 13g of borneol, 13g of dragon's blood, 13g of calomel, 1050g of vaseline and 330g of corn oil.
Crushing gypsum, heating in a smokeless furnace, and calcining to be loose to obtain calcined gypsum;
heating Margarita at 85 deg.C until detonation stops, taking out, cooling, grinding into powder, adding water, grinding, adding water, stirring, decanting the suspension, standing, collecting precipitate, and drying to obtain Margarita powder;
heating calamine to be red thoroughly at 100 ℃, taking out and soaking in water, stirring, taking out upper layer suspension, and drying to obtain calamine powder;
crushing Os Draconis, heating at 100 deg.C to red, taking out, cooling, and crushing into powder to obtain Os Draconis powder;
crushing cinnabar into powder, pouring the powder into water, stirring, taking the upper suspension, and drying to obtain cinnabar powder;
respectively crushing the other raw materials except the vaseline and the corn oil into powder;
mixing vaseline and corn oil, heating to boil, heating for 5min, adding calcined Gypsum Fibrosum, Margarita powder, Calamina powder, Os Draconis powder and Cinnabaris powder, stirring, slowly cooling to 45 deg.C, adding the rest raw materials, and stirring to obtain the final product.
Example 5
A preparation method of a traditional Chinese medicine preparation for treating skin trauma comprises the following steps:
raw materials: 250g of gypsum, 75g of pearl, 75g of calamine, 15g of keel, 15g of cinnabar, 15g of borneol, 15g of dragon's blood, 15g of calomel, 1100g of vaseline and 350g of corn oil.
Crushing gypsum, heating in a smokeless furnace, and calcining to be loose to obtain calcined gypsum;
heating Margarita at 90 deg.C until detonation stops, taking out, cooling, grinding into powder, adding water, grinding, adding water, stirring, decanting the suspension, standing, collecting precipitate, and drying to obtain Margarita powder;
heating calamine to red thoroughly at 105 ℃, taking out and soaking in water, stirring, taking out upper layer suspension, and drying to obtain calamine powder;
crushing Os Draconis, heating at 105 deg.C to red, taking out, cooling, and crushing into powder to obtain Os Draconis powder;
crushing cinnabar into powder, pouring the powder into water, stirring, taking the upper suspension, and drying to obtain cinnabar powder;
respectively crushing the other raw materials except the vaseline and the corn oil into powder;
mixing vaseline and corn oil, heating to boil, heating for 5min, adding calcined Gypsum Fibrosum, Margarita powder, Calamina powder, Os Draconis powder and Cinnabaris powder, stirring, slowly cooling to 45 deg.C, adding the rest raw materials, and stirring to obtain the final product.
Example 6
This example is substantially the same as example 1, except that: also comprises 5g of cattail pollen, 3g of Siberian loosestrife herb, 3g of camellia flower, 2g of green tangerine peel, 3g of Galium verum, 2g of ramie root, 1g of cymbidium, 3g of silybum marianum and 3g of limonium aureum.
Example 7
This example is substantially the same as example 2, except that: also comprises 8g of cattail pollen, 5g of Siberian loosestrife herb, 5g of camellia, 4g of green tangerine peel, 5-g of Galium verum, 3g of ramie root, 2g of Ru lan, 4g of silybum marianum and 4g of limonium aureum.
Example 8
This example is substantially the same as example 3, except that: also comprises 10g of cattail pollen, 7g of Siberian loosestrife herb, 7g of camellia, 5g of green tangerine peel, 6g of Galium verum, 4g of ramie root, 3g of Ru lan, 5g of silybum marianum and 5g of limonium aureum.
Example 9
This example is substantially the same as example 4, except that: also comprises pollen Typhae 12g, herba Sidae Rhombifoliae 8g, flos Camelliae Japonicae 8g, pericarpium Citri Reticulatae viride 6g, herba Pachyrhizi Erosi 7g, radix Boehmeriae 5g, radix Stephaniae Henryi 4g, herba Silybi Mariani 6g and herba Lissatiae 6 g.
Example 10
This example is substantially the same as example 5, except that: also comprises 15g of cattail pollen, 10g of Siberian loosestrife herb, 10g of camellia, 8g of green tangerine peel, 8g of Galium verum, 5g of ramie root, 5g of cymbidium, 8g of silybum marianum and 8g of limonium aureum.
Comparative example
This comparative example is essentially the same as example 3, except that: no keel was added.
Examples of the experiments
(I) skin irritation test
150 rats weighing 250-300g are taken and fed adaptively for 3d, the abdominal parts of the rats are cut off with 3 multiplied by 3cm hairs 24h in advance to ensure that the skin of a hair-removed area is intact, the rats are equally divided into 3 groups, 1 group is ground by abrasive paper to remove the hair-removed part, the blood seepage of the hair-removed part is caused, 2 groups are kept intact, and 3 groups are used as blank controls. The mice were divided into 5 groups for each of the intact skin group and the damaged group, and the experiment was performed by coating the mice with the herbal preparations of example 1, example 3, example 5, example 8 and example 10, respectively. The skin condition was observed before, after 1h, after 1d, after 3d and 7d, respectively. The results are shown in Table 1.
TABLE 1
Figure BDA0003559252750000161
By observing the table 1, the traditional Chinese medicine preparation prepared by the application is safe and mild and has no irritation to skin.
(II) test of drug efficacy
The traditional Chinese medicine preparations prepared in the embodiment 1, the embodiment 3, the embodiment 5, the embodiment 8 and the comparative example of the application are used for treating 100 patients with the second-degree scalds, the patients with the scalds are divided into 5 groups, and the treatment is respectively carried out by using each traditional Chinese medicine preparation.
The treatment method comprises the following steps: the Chinese medicinal preparation is coated on the wound in the morning and evening every day, and the wound healing condition is checked, and the result is shown in table 2.
TABLE 2
Test specimen Time to complete healing of wound surface Total significant efficiency/%)
Example 1 14±2.0 80
Example 3 10±2.2 90
Example 5 11±1.5 85
Example 8 8±2.0 100
Comparative example 18±2.5 60
In combination with table 2, it can be seen that the Chinese medicinal preparation prepared by the present application has outstanding therapeutic effect on skin trauma and short treatment period, and the comparison shows that the therapeutic effect of example 3 and example 8 is the best. As can be seen from the comparison of example 3 and the comparative example, the lack of keel results in a great decrease in the efficacy of the whole drug, since the Chinese medicinal preparation is a result of the synergistic effect of a plurality of drugs.
In conclusion, the inventor uses borneol to clear liver heat (blood stasis and heat transformation cause liver depression), uses dragon's bone to enter liver meridian to calm liver and suppress yang, uses dragon's blood and dragon's bone to promote blood circulation and nourish tendons and vessels, uses dragon's blood, cinnabar and gypsum to stop bleeding and remove blood stasis, and uses calamine, calomel, dragon's blood and gypsum to promote tissue regeneration and heal wound. The vaseline and the corn oil can keep the affected part moist and a relatively closed environment, and can be beneficial to the recovery of the affected part. The medicines have the combined action to promote the recovery of skin trauma, especially have the prominent effect on old injuries, and also have obvious effects on eczema, fester, burn, diabetic foot and postoperative repair.
The embodiments described above are some, but not all embodiments of the present application. The detailed description of the embodiments of the present application is not intended to limit the scope of the claimed application, but is merely representative of selected embodiments of the application. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present application.

Claims (10)

1. A traditional Chinese medicine preparation for treating skin trauma is characterized by comprising, by weight, 150-250 parts of gypsum, 25-75 parts of pearl, 25-75 parts of calamine, 5-15 parts of keel, 5-15 parts of cinnabar, 5-15 parts of borneol, 5-15 parts of dragon's blood, 5-15 parts of calomel, 900-1100 parts of vaseline and 350 parts of corn oil.
2. The traditional Chinese medicine preparation for treating skin trauma as claimed in claim 1, wherein the traditional Chinese medicine preparation comprises, by weight, 180-230 parts of gypsum, 40-60 parts of pearl, 40-60 parts of calamine, 8-13 parts of keel, 8-13 parts of cinnabar, 8-13 parts of borneol, 8-13 parts of dragon's blood, 8-13 parts of calomel, 950-1050 parts of vaseline and 330 parts of corn oil 280-cake.
3. The traditional Chinese medicine preparation for treating skin trauma according to claim 1, characterized by further comprising 5-15 parts by weight of cattail pollen, 3-10 parts by weight of chloranthus japonicus, 3-10 parts by weight of camellia japonica, 2-8 parts by weight of green tangerine peel, 3-8 parts by weight of pachyrhizua angulatus, 2-5 parts by weight of ramie root, 1-5 parts by weight of cymbidium ruthenicum, 3-8 parts by weight of silybum marianum and 3-8 parts by weight of limonium aureum.
4. The traditional Chinese medicine preparation for treating skin trauma as claimed in claim 3, wherein the traditional Chinese medicine preparation comprises, by weight, 180-230 parts of gypsum, 40-60 parts of pearl, 40-60 parts of calamine, 8-13 parts of keel, 8-13 parts of cinnabar, 8-13 parts of borneol, 8-13 parts of dragon's blood, 8-13 parts of calomel, 950-1050 parts of vaseline, 330 parts of corn oil 280-containing material, 8-12 parts of cattail pollen, 5-8 parts of starwort, 5-8 parts of camellia, 4-6 parts of green tangerine orange peel, 5-7 parts of dulcamara, 3-5 parts of ramie root, 2-4 parts of cymbidium, 4-6 parts of silybum marianum and 4-6 parts of limonium aureum.
5. The method for preparing a Chinese medicinal preparation for treating skin trauma as claimed in any one of claims 1 to 4, comprising the steps of:
crushing gypsum, heating in a smokeless furnace, and calcining to be loose to obtain calcined gypsum;
heating Margarita until detonation stops, taking out, cooling, grinding into powder, adding water, grinding, adding water, stirring, decanting the suspension, standing, collecting precipitate, and drying to obtain Margarita powder;
heating calamine to be red, taking out and soaking in water, stirring, taking an upper layer suspension, and drying to obtain calamine powder;
crushing Os Draconis, heating to red, taking out, cooling, and crushing into powder to obtain Os Draconis powder;
crushing cinnabar into powder, pouring the powder into water, stirring, taking the upper suspension, and drying to obtain cinnabar powder;
respectively crushing the other raw materials except the vaseline and the corn oil into powder;
mixing vaseline and corn oil, heating to boil, adding calcined gypsum, pearl powder, calamine powder, Os Draconis powder and cinnabar powder, stirring, slowly cooling, adding the rest raw materials, and stirring to obtain the final product.
6. The Chinese medicinal preparation for treating skin trauma according to claim 5, wherein the heating temperature of the pearls is 70-90 ℃.
7. The Chinese medicinal preparation for treating skin trauma according to claim 5, wherein the heating temperature of the calamine is 95-105 ℃.
8. The Chinese medicinal preparation for treating skin trauma as claimed in claim 5, wherein the heating temperature of the keel is 95-105 ℃.
9. The Chinese medicinal preparation for treating skin trauma according to claim 5, wherein the vaseline and the corn oil are mixed and heated to a temperature, and then continuously heated for 3-5min, and then calcined gypsum, pearl powder, calamine powder, dragon bone powder and cinnabar powder are added.
10. The Chinese medicinal preparation for treating skin trauma according to claim 5, wherein the cooling temperature is 35-45 ℃.
CN202210283817.9A 2022-03-22 2022-03-22 Traditional Chinese medicine preparation for treating skin trauma and preparation method thereof Pending CN114404532A (en)

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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1544003A (en) * 2003-11-13 2004-11-10 西安碑林药业股份有限公司 Medicine for treating trauma and sores and its preparing process
CN103830478A (en) * 2014-02-13 2014-06-04 马翠霞 Medicine for treatment of skin ulcer
CN107375708A (en) * 2017-08-04 2017-11-24 顾倪瑄 A kind of wound Chinese medicine

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1544003A (en) * 2003-11-13 2004-11-10 西安碑林药业股份有限公司 Medicine for treating trauma and sores and its preparing process
CN103830478A (en) * 2014-02-13 2014-06-04 马翠霞 Medicine for treatment of skin ulcer
CN107375708A (en) * 2017-08-04 2017-11-24 顾倪瑄 A kind of wound Chinese medicine

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