CN107823592A - A kind of external application anti-tumor Chinese medicine cream - Google Patents
A kind of external application anti-tumor Chinese medicine cream Download PDFInfo
- Publication number
- CN107823592A CN107823592A CN201711147501.2A CN201711147501A CN107823592A CN 107823592 A CN107823592 A CN 107823592A CN 201711147501 A CN201711147501 A CN 201711147501A CN 107823592 A CN107823592 A CN 107823592A
- Authority
- CN
- China
- Prior art keywords
- parts
- root
- chinese
- external application
- bark
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000003814 drug Substances 0.000 title claims abstract description 69
- 230000000259 anti-tumor effect Effects 0.000 title claims abstract description 53
- 239000006071 cream Substances 0.000 title claims abstract description 38
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 claims abstract description 33
- REPVLJRCJUVQFA-UHFFFAOYSA-N (-)-isopinocampheol Natural products C1C(O)C(C)C2C(C)(C)C1C2 REPVLJRCJUVQFA-UHFFFAOYSA-N 0.000 claims abstract description 33
- 235000006040 Prunus persica var persica Nutrition 0.000 claims abstract description 33
- 229940116229 borneol Drugs 0.000 claims abstract description 33
- CKDOCTFBFTVPSN-UHFFFAOYSA-N borneol Natural products C1CC2(C)C(C)CC1C2(C)C CKDOCTFBFTVPSN-UHFFFAOYSA-N 0.000 claims abstract description 33
- DTGKSKDOIYIVQL-UHFFFAOYSA-N dl-isoborneol Natural products C1CC2(C)C(O)CC1C2(C)C DTGKSKDOIYIVQL-UHFFFAOYSA-N 0.000 claims abstract description 33
- 244000046146 Pueraria lobata Species 0.000 claims abstract description 29
- 235000010575 Pueraria lobata Nutrition 0.000 claims abstract description 29
- 235000014066 European mistletoe Nutrition 0.000 claims abstract description 28
- 239000009636 Huang Qi Substances 0.000 claims abstract description 28
- 244000234609 Portulaca oleracea Species 0.000 claims abstract description 28
- 235000001855 Portulaca oleracea Nutrition 0.000 claims abstract description 28
- 241001504477 Pycnonotidae Species 0.000 claims abstract description 28
- 235000012300 Rhipsalis cassutha Nutrition 0.000 claims abstract description 28
- 235000006886 Zingiber officinale Nutrition 0.000 claims abstract description 28
- 235000008397 ginger Nutrition 0.000 claims abstract description 28
- 240000008027 Akebia quinata Species 0.000 claims abstract description 27
- 235000007756 Akebia quinata Nutrition 0.000 claims abstract description 27
- 241000675108 Citrus tangerina Species 0.000 claims abstract description 27
- 235000014075 Juglans mandschurica Nutrition 0.000 claims abstract description 27
- 244000264601 Juglans mandschurica Species 0.000 claims abstract description 27
- 241000112528 Ligusticum striatum Species 0.000 claims abstract description 27
- 240000005001 Paeonia suffruticosa Species 0.000 claims abstract description 27
- 235000003889 Paeonia suffruticosa Nutrition 0.000 claims abstract description 27
- 241001522129 Pinellia Species 0.000 claims abstract description 27
- 241000522620 Scorpio Species 0.000 claims abstract description 27
- 235000008326 Trichosanthes anguina Nutrition 0.000 claims abstract description 27
- 244000078912 Trichosanthes cucumerina Species 0.000 claims abstract description 27
- 235000013399 edible fruits Nutrition 0.000 claims abstract description 27
- 239000009490 scorpio Substances 0.000 claims abstract description 27
- 241000219068 Actinidia Species 0.000 claims abstract description 26
- 244000144730 Amygdalus persica Species 0.000 claims abstract description 26
- 241000521581 Millettia Species 0.000 claims abstract description 26
- 240000000260 Typha latifolia Species 0.000 claims abstract description 26
- 244000178320 Vaccaria pyramidata Species 0.000 claims abstract description 26
- 235000010587 Vaccaria pyramidata Nutrition 0.000 claims abstract description 26
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 claims abstract description 25
- 235000017443 Hedysarum boreale Nutrition 0.000 claims abstract description 25
- 235000007858 Hedysarum occidentale Nutrition 0.000 claims abstract description 25
- 240000008488 Thlaspi arvense Species 0.000 claims abstract description 25
- 235000008214 Thlaspi arvense Nutrition 0.000 claims abstract description 25
- 239000001947 glycyrrhiza glabra rhizome/root Substances 0.000 claims abstract description 25
- 241000132171 Phryma leptostachya Species 0.000 claims abstract description 22
- 241000237502 Ostreidae Species 0.000 claims abstract description 21
- 235000020636 oyster Nutrition 0.000 claims abstract description 21
- 239000002994 raw material Substances 0.000 claims abstract description 14
- 244000273928 Zingiber officinale Species 0.000 claims abstract description 9
- 244000303040 Glycyrrhiza glabra Species 0.000 claims abstract 6
- 244000152640 Rhipsalis cassutha Species 0.000 claims abstract 6
- 239000008280 blood Substances 0.000 claims description 33
- 210000004369 blood Anatomy 0.000 claims description 33
- 239000000843 powder Substances 0.000 claims description 24
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 13
- 239000000706 filtrate Substances 0.000 claims description 12
- 238000002360 preparation method Methods 0.000 claims description 12
- 240000005809 Prunus persica Species 0.000 claims description 7
- 238000010791 quenching Methods 0.000 claims description 7
- 235000013339 cereals Nutrition 0.000 claims description 6
- 238000000227 grinding Methods 0.000 claims description 6
- 235000021419 vinegar Nutrition 0.000 claims description 6
- 239000000052 vinegar Substances 0.000 claims description 6
- 238000005303 weighing Methods 0.000 claims description 6
- 240000001592 Amaranthus caudatus Species 0.000 claims 1
- 235000009328 Amaranthus caudatus Nutrition 0.000 claims 1
- 241000345998 Calamus manan Species 0.000 claims 1
- 240000004528 Catalpa ovata Species 0.000 claims 1
- 235000010005 Catalpa ovata Nutrition 0.000 claims 1
- 241000287828 Gallus gallus Species 0.000 claims 1
- 240000007049 Juglans regia Species 0.000 claims 1
- 235000009496 Juglans regia Nutrition 0.000 claims 1
- 244000228367 Lewisia rediviva Species 0.000 claims 1
- 235000007279 Lewisia rediviva Nutrition 0.000 claims 1
- 235000012735 amaranth Nutrition 0.000 claims 1
- 239000004178 amaranth Substances 0.000 claims 1
- 239000008188 pellet Substances 0.000 claims 1
- 235000012950 rattan cane Nutrition 0.000 claims 1
- 235000020234 walnut Nutrition 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 abstract description 41
- 208000002193 Pain Diseases 0.000 abstract description 31
- 230000036407 pain Effects 0.000 abstract description 30
- 201000011510 cancer Diseases 0.000 abstract description 25
- 210000004881 tumor cell Anatomy 0.000 abstract description 6
- 230000001976 improved effect Effects 0.000 abstract description 5
- 230000006907 apoptotic process Effects 0.000 abstract description 4
- 206010003445 Ascites Diseases 0.000 abstract description 3
- 206010048612 Hydrothorax Diseases 0.000 abstract description 3
- 230000004663 cell proliferation Effects 0.000 abstract description 3
- 230000017074 necrotic cell death Effects 0.000 abstract description 3
- 238000006243 chemical reaction Methods 0.000 abstract description 2
- 230000002496 gastric effect Effects 0.000 abstract description 2
- 238000005469 granulation Methods 0.000 abstract description 2
- 230000003179 granulation Effects 0.000 abstract description 2
- 229940126701 oral medication Drugs 0.000 abstract description 2
- 230000017423 tissue regeneration Effects 0.000 abstract description 2
- 230000001737 promoting effect Effects 0.000 description 29
- 210000004185 liver Anatomy 0.000 description 24
- 241000221012 Viscum Species 0.000 description 22
- 230000017531 blood circulation Effects 0.000 description 22
- 241000244355 Ligusticum Species 0.000 description 19
- 241000234314 Zingiber Species 0.000 description 19
- 230000000694 effects Effects 0.000 description 19
- 210000003734 kidney Anatomy 0.000 description 17
- 210000000952 spleen Anatomy 0.000 description 15
- 210000002784 stomach Anatomy 0.000 description 14
- 229940079593 drug Drugs 0.000 description 13
- 210000004072 lung Anatomy 0.000 description 11
- 231100000614 poison Toxicity 0.000 description 11
- 210000000038 chest Anatomy 0.000 description 10
- 238000012360 testing method Methods 0.000 description 10
- 206010007247 Carbuncle Diseases 0.000 description 9
- 208000004880 Polyuria Diseases 0.000 description 9
- 210000004027 cell Anatomy 0.000 description 9
- 235000009508 confectionery Nutrition 0.000 description 9
- 230000035619 diuresis Effects 0.000 description 9
- 208000024891 symptom Diseases 0.000 description 9
- 244000025254 Cannabis sativa Species 0.000 description 8
- 206010062717 Increased upper airway secretion Diseases 0.000 description 8
- 210000000988 bone and bone Anatomy 0.000 description 8
- 201000010099 disease Diseases 0.000 description 8
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 8
- 201000001441 melanoma Diseases 0.000 description 8
- 208000026435 phlegm Diseases 0.000 description 8
- 206010011224 Cough Diseases 0.000 description 7
- 239000000796 flavoring agent Substances 0.000 description 7
- 235000019634 flavors Nutrition 0.000 description 7
- 239000003440 toxic substance Substances 0.000 description 7
- 206010067484 Adverse reaction Diseases 0.000 description 6
- 206010047700 Vomiting Diseases 0.000 description 6
- 210000001015 abdomen Anatomy 0.000 description 6
- 230000006838 adverse reaction Effects 0.000 description 6
- 230000007812 deficiency Effects 0.000 description 6
- 230000002708 enhancing effect Effects 0.000 description 6
- 150000004676 glycans Chemical class 0.000 description 6
- 244000052769 pathogen Species 0.000 description 6
- 229920001282 polysaccharide Polymers 0.000 description 6
- 239000005017 polysaccharide Substances 0.000 description 6
- 210000004872 soft tissue Anatomy 0.000 description 6
- 238000005728 strengthening Methods 0.000 description 6
- 230000008961 swelling Effects 0.000 description 6
- 206010012735 Diarrhoea Diseases 0.000 description 5
- 206010037660 Pyrexia Diseases 0.000 description 5
- 208000027418 Wounds and injury Diseases 0.000 description 5
- 230000006378 damage Effects 0.000 description 5
- 238000000338 in vitro Methods 0.000 description 5
- 238000000034 method Methods 0.000 description 5
- 239000002574 poison Substances 0.000 description 5
- 201000000736 Amenorrhea Diseases 0.000 description 4
- 206010001928 Amenorrhoea Diseases 0.000 description 4
- 206010004146 Basal cell carcinoma Diseases 0.000 description 4
- 206010013935 Dysmenorrhoea Diseases 0.000 description 4
- 206010019233 Headaches Diseases 0.000 description 4
- 208000032843 Hemorrhage Diseases 0.000 description 4
- 206010036790 Productive cough Diseases 0.000 description 4
- 206010039491 Sarcoma Diseases 0.000 description 4
- 208000025865 Ulcer Diseases 0.000 description 4
- 230000035508 accumulation Effects 0.000 description 4
- 238000009825 accumulation Methods 0.000 description 4
- 231100000540 amenorrhea Toxicity 0.000 description 4
- 210000004204 blood vessel Anatomy 0.000 description 4
- 210000000481 breast Anatomy 0.000 description 4
- 230000004087 circulation Effects 0.000 description 4
- 231100000869 headache Toxicity 0.000 description 4
- 210000003127 knee Anatomy 0.000 description 4
- 210000002429 large intestine Anatomy 0.000 description 4
- 208000004396 mastitis Diseases 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- 230000007246 mechanism Effects 0.000 description 4
- 210000003205 muscle Anatomy 0.000 description 4
- 230000001717 pathogenic effect Effects 0.000 description 4
- 230000001105 regulatory effect Effects 0.000 description 4
- 231100000331 toxic Toxicity 0.000 description 4
- 231100000167 toxic agent Toxicity 0.000 description 4
- 230000002588 toxic effect Effects 0.000 description 4
- 239000003053 toxin Substances 0.000 description 4
- 231100000765 toxin Toxicity 0.000 description 4
- 210000001835 viscera Anatomy 0.000 description 4
- 208000006820 Arthralgia Diseases 0.000 description 3
- 208000037093 Menstruation Disturbances Diseases 0.000 description 3
- 206010027339 Menstruation irregular Diseases 0.000 description 3
- 208000012287 Prolapse Diseases 0.000 description 3
- 208000009205 Tinnitus Diseases 0.000 description 3
- 206010046788 Uterine haemorrhage Diseases 0.000 description 3
- 230000009471 action Effects 0.000 description 3
- 230000000202 analgesic effect Effects 0.000 description 3
- 230000008901 benefit Effects 0.000 description 3
- 230000000740 bleeding effect Effects 0.000 description 3
- 208000002173 dizziness Diseases 0.000 description 3
- 208000001848 dysentery Diseases 0.000 description 3
- 230000014509 gene expression Effects 0.000 description 3
- 230000036039 immunity Effects 0.000 description 3
- 230000001939 inductive effect Effects 0.000 description 3
- 230000002401 inhibitory effect Effects 0.000 description 3
- 208000014674 injury Diseases 0.000 description 3
- 239000002674 ointment Substances 0.000 description 3
- 210000000056 organ Anatomy 0.000 description 3
- 230000000144 pharmacologic effect Effects 0.000 description 3
- 230000007096 poisonous effect Effects 0.000 description 3
- 230000003014 reinforcing effect Effects 0.000 description 3
- 230000002269 spontaneous effect Effects 0.000 description 3
- 238000001356 surgical procedure Methods 0.000 description 3
- 230000035900 sweating Effects 0.000 description 3
- 231100000886 tinnitus Toxicity 0.000 description 3
- 231100000397 ulcer Toxicity 0.000 description 3
- 230000008673 vomiting Effects 0.000 description 3
- 238000010792 warming Methods 0.000 description 3
- 206010000077 Abdominal mass Diseases 0.000 description 2
- 206010000087 Abdominal pain upper Diseases 0.000 description 2
- 206010006187 Breast cancer Diseases 0.000 description 2
- 208000026310 Breast neoplasm Diseases 0.000 description 2
- 206010010774 Constipation Diseases 0.000 description 2
- 241000721047 Danaus plexippus Species 0.000 description 2
- 208000005171 Dysmenorrhea Diseases 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 2
- 108090000790 Enzymes Proteins 0.000 description 2
- 208000015817 Infant Nutrition disease Diseases 0.000 description 2
- 206010030113 Oedema Diseases 0.000 description 2
- 206010033557 Palpitations Diseases 0.000 description 2
- 244000148137 Patrinia villosa Species 0.000 description 2
- 235000019109 Patrinia villosa Nutrition 0.000 description 2
- 208000001431 Psychomotor Agitation Diseases 0.000 description 2
- 206010038743 Restlessness Diseases 0.000 description 2
- 206010067868 Skin mass Diseases 0.000 description 2
- 208000021712 Soft tissue sarcoma Diseases 0.000 description 2
- 206010042674 Swelling Diseases 0.000 description 2
- 206010044684 Trismus Diseases 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 2
- 230000002411 adverse Effects 0.000 description 2
- 230000002776 aggregation Effects 0.000 description 2
- 238000004220 aggregation Methods 0.000 description 2
- 208000002399 aphthous stomatitis Diseases 0.000 description 2
- 230000001174 ascending effect Effects 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 238000002512 chemotherapy Methods 0.000 description 2
- 230000001276 controlling effect Effects 0.000 description 2
- 230000036461 convulsion Effects 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- 208000035250 cutaneous malignant susceptibility to 1 melanoma Diseases 0.000 description 2
- 230000034994 death Effects 0.000 description 2
- 206010012601 diabetes mellitus Diseases 0.000 description 2
- 230000001079 digestive effect Effects 0.000 description 2
- 230000008030 elimination Effects 0.000 description 2
- 238000003379 elimination reaction Methods 0.000 description 2
- 238000011049 filling Methods 0.000 description 2
- 239000001963 growth medium Substances 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 208000014617 hemorrhoid Diseases 0.000 description 2
- 230000023597 hemostasis Effects 0.000 description 2
- 208000006278 hypochromic anemia Diseases 0.000 description 2
- 244000000053 intestinal parasite Species 0.000 description 2
- 210000000936 intestine Anatomy 0.000 description 2
- 201000005630 leukorrhea Diseases 0.000 description 2
- 230000007774 longterm Effects 0.000 description 2
- 201000007227 lymph node tuberculosis Diseases 0.000 description 2
- 230000003211 malignant effect Effects 0.000 description 2
- 230000004089 microcirculation Effects 0.000 description 2
- 230000001114 myogenic effect Effects 0.000 description 2
- 231100000862 numbness Toxicity 0.000 description 2
- 206010033675 panniculitis Diseases 0.000 description 2
- 210000003516 pericardium Anatomy 0.000 description 2
- 230000000505 pernicious effect Effects 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 239000001397 quillaja saponaria molina bark Substances 0.000 description 2
- 238000001959 radiotherapy Methods 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 229930182490 saponin Natural products 0.000 description 2
- 150000007949 saponins Chemical class 0.000 description 2
- 210000000697 sensory organ Anatomy 0.000 description 2
- 208000024794 sputum Diseases 0.000 description 2
- 210000003802 sputum Anatomy 0.000 description 2
- 206010041823 squamous cell carcinoma Diseases 0.000 description 2
- 210000004304 subcutaneous tissue Anatomy 0.000 description 2
- 230000003319 supportive effect Effects 0.000 description 2
- 208000011580 syndromic disease Diseases 0.000 description 2
- 238000002560 therapeutic procedure Methods 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- 206010046901 vaginal discharge Diseases 0.000 description 2
- 239000001100 (2S)-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one Substances 0.000 description 1
- HJTAZXHBEBIQQX-UHFFFAOYSA-N 1,5-bis(chloromethyl)naphthalene Chemical compound C1=CC=C2C(CCl)=CC=CC2=C1CCl HJTAZXHBEBIQQX-UHFFFAOYSA-N 0.000 description 1
- 102000010400 1-phosphatidylinositol-3-kinase activity proteins Human genes 0.000 description 1
- QGZCUOLOTMJILH-UHFFFAOYSA-N 2h-tetrazol-2-ium;bromide Chemical compound [Br-].C1=N[NH+]=NN1 QGZCUOLOTMJILH-UHFFFAOYSA-N 0.000 description 1
- 208000004998 Abdominal Pain Diseases 0.000 description 1
- 206010000060 Abdominal distension Diseases 0.000 description 1
- 208000002874 Acne Vulgaris Diseases 0.000 description 1
- 235000009436 Actinidia deliciosa Nutrition 0.000 description 1
- 208000008710 Amebic Dysentery Diseases 0.000 description 1
- 206010001986 Amoebic dysentery Diseases 0.000 description 1
- 206010002383 Angina Pectoris Diseases 0.000 description 1
- 206010003011 Appendicitis Diseases 0.000 description 1
- 235000017060 Arachis glabrata Nutrition 0.000 description 1
- 244000105624 Arachis hypogaea Species 0.000 description 1
- 235000010777 Arachis hypogaea Nutrition 0.000 description 1
- 235000018262 Arachis monticola Nutrition 0.000 description 1
- 240000006063 Averrhoa carambola Species 0.000 description 1
- 208000004429 Bacillary Dysentery Diseases 0.000 description 1
- 206010005003 Bladder cancer Diseases 0.000 description 1
- 208000019838 Blood disease Diseases 0.000 description 1
- 206010006002 Bone pain Diseases 0.000 description 1
- 206010006272 Breast mass Diseases 0.000 description 1
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 1
- 206010007027 Calculus urinary Diseases 0.000 description 1
- 206010008190 Cerebrovascular accident Diseases 0.000 description 1
- 206010010071 Coma Diseases 0.000 description 1
- 206010010741 Conjunctivitis Diseases 0.000 description 1
- 206010010904 Convulsion Diseases 0.000 description 1
- 206010011878 Deafness Diseases 0.000 description 1
- 201000004624 Dermatitis Diseases 0.000 description 1
- 206010014080 Ecchymosis Diseases 0.000 description 1
- 244000148064 Enicostema verticillatum Species 0.000 description 1
- 208000008967 Enuresis Diseases 0.000 description 1
- 201000008808 Fibrosarcoma Diseases 0.000 description 1
- 206010017553 Furuncle Diseases 0.000 description 1
- 208000012895 Gastric disease Diseases 0.000 description 1
- 208000005577 Gastroenteritis Diseases 0.000 description 1
- 206010017915 Gastroenteritis shigella Diseases 0.000 description 1
- 206010018612 Gonorrhoea Diseases 0.000 description 1
- 206010019468 Hemiplegia Diseases 0.000 description 1
- 206010019909 Hernia Diseases 0.000 description 1
- 208000007514 Herpes zoster Diseases 0.000 description 1
- 206010020772 Hypertension Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 206010022998 Irritability Diseases 0.000 description 1
- 206010023126 Jaundice Diseases 0.000 description 1
- 206010024612 Lipoma Diseases 0.000 description 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 description 1
- 206010025323 Lymphomas Diseases 0.000 description 1
- 102000043136 MAP kinase family Human genes 0.000 description 1
- 108091054455 MAP kinase family Proteins 0.000 description 1
- 201000005505 Measles Diseases 0.000 description 1
- 208000019695 Migraine disease Diseases 0.000 description 1
- IKMDFBPHZNJCSN-UHFFFAOYSA-N Myricetin Chemical compound C=1C(O)=CC(O)=C(C(C=2O)=O)C=1OC=2C1=CC(O)=C(O)C(O)=C1 IKMDFBPHZNJCSN-UHFFFAOYSA-N 0.000 description 1
- 206010028813 Nausea Diseases 0.000 description 1
- 206010028836 Neck pain Diseases 0.000 description 1
- 108700020796 Oncogene Proteins 0.000 description 1
- 108091007960 PI3Ks Proteins 0.000 description 1
- 206010033799 Paralysis Diseases 0.000 description 1
- 208000008350 Pruritus Vulvae Diseases 0.000 description 1
- 206010067171 Regurgitation Diseases 0.000 description 1
- 208000001647 Renal Insufficiency Diseases 0.000 description 1
- 208000025747 Rheumatic disease Diseases 0.000 description 1
- 206010039509 Scab Diseases 0.000 description 1
- 208000005392 Spasm Diseases 0.000 description 1
- 206010042170 Strangury Diseases 0.000 description 1
- 208000006011 Stroke Diseases 0.000 description 1
- 206010044565 Tremor Diseases 0.000 description 1
- 244000134857 Typha capensis Species 0.000 description 1
- 208000012886 Vertigo Diseases 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 206010056530 Vulvovaginal pruritus Diseases 0.000 description 1
- 206010000269 abscess Diseases 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 206010000496 acne Diseases 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 208000012873 acute gastroenteritis Diseases 0.000 description 1
- 230000037006 agalactosis Effects 0.000 description 1
- 230000036592 analgesia Effects 0.000 description 1
- 230000000118 anti-neoplastic effect Effects 0.000 description 1
- 230000001663 anti-spastic effect Effects 0.000 description 1
- 210000000436 anus Anatomy 0.000 description 1
- 229910052785 arsenic Inorganic materials 0.000 description 1
- RQNWIZPPADIBDY-UHFFFAOYSA-N arsenic atom Chemical compound [As] RQNWIZPPADIBDY-UHFFFAOYSA-N 0.000 description 1
- GOLCXWYRSKYTSP-UHFFFAOYSA-N arsenic trioxide Inorganic materials O1[As]2O[As]1O2 GOLCXWYRSKYTSP-UHFFFAOYSA-N 0.000 description 1
- 125000003118 aryl group Chemical group 0.000 description 1
- 208000006673 asthma Diseases 0.000 description 1
- 208000010668 atopic eczema Diseases 0.000 description 1
- 230000004900 autophagic degradation Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000008033 biological extinction Effects 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 201000001531 bladder carcinoma Diseases 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 210000001185 bone marrow Anatomy 0.000 description 1
- 239000006285 cell suspension Substances 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 208000019902 chronic diarrheal disease Diseases 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 231100000895 deafness Toxicity 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 230000008034 disappearance Effects 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 230000004064 dysfunction Effects 0.000 description 1
- 230000003028 elevating effect Effects 0.000 description 1
- 230000003073 embolic effect Effects 0.000 description 1
- 230000008451 emotion Effects 0.000 description 1
- 206010014881 enterobiasis Diseases 0.000 description 1
- 206010015037 epilepsy Diseases 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 210000001508 eye Anatomy 0.000 description 1
- 230000004438 eyesight Effects 0.000 description 1
- 210000000887 face Anatomy 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 230000001605 fetal effect Effects 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 210000004907 gland Anatomy 0.000 description 1
- 208000001786 gonorrhea Diseases 0.000 description 1
- 208000016354 hearing loss disease Diseases 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 208000014951 hematologic disease Diseases 0.000 description 1
- 208000018706 hematopoietic system disease Diseases 0.000 description 1
- AIONOLUJZLIMTK-AWEZNQCLSA-N hesperetin Chemical compound C1=C(O)C(OC)=CC=C1[C@H]1OC2=CC(O)=CC(O)=C2C(=O)C1 AIONOLUJZLIMTK-AWEZNQCLSA-N 0.000 description 1
- 229960001587 hesperetin Drugs 0.000 description 1
- AIONOLUJZLIMTK-UHFFFAOYSA-N hesperetin Natural products C1=C(O)C(OC)=CC=C1C1OC2=CC(O)=CC(O)=C2C(=O)C1 AIONOLUJZLIMTK-UHFFFAOYSA-N 0.000 description 1
- 235000010209 hesperetin Nutrition 0.000 description 1
- 210000001624 hip Anatomy 0.000 description 1
- FTODBIPDTXRIGS-UHFFFAOYSA-N homoeriodictyol Natural products C1=C(O)C(OC)=CC(C2OC3=CC(O)=CC(O)=C3C(=O)C2)=C1 FTODBIPDTXRIGS-UHFFFAOYSA-N 0.000 description 1
- 230000036737 immune function Effects 0.000 description 1
- 201000001881 impotence Diseases 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 230000006698 induction Effects 0.000 description 1
- 230000008595 infiltration Effects 0.000 description 1
- 238000001764 infiltration Methods 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 201000006370 kidney failure Diseases 0.000 description 1
- 210000000867 larynx Anatomy 0.000 description 1
- 238000002386 leaching Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 201000007270 liver cancer Diseases 0.000 description 1
- 208000014018 liver neoplasm Diseases 0.000 description 1
- 201000005202 lung cancer Diseases 0.000 description 1
- 208000020816 lung neoplasm Diseases 0.000 description 1
- 210000001165 lymph node Anatomy 0.000 description 1
- 210000001365 lymphatic vessel Anatomy 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 210000005075 mammary gland Anatomy 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000002175 menstrual effect Effects 0.000 description 1
- 208000004197 mesenchymoma Diseases 0.000 description 1
- 230000027939 micturition Effects 0.000 description 1
- 206010027599 migraine Diseases 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- 229940116852 myricetin Drugs 0.000 description 1
- PCOBUQBNVYZTBU-UHFFFAOYSA-N myricetin Natural products OC1=C(O)C(O)=CC(C=2OC3=CC(O)=C(O)C(O)=C3C(=O)C=2)=C1 PCOBUQBNVYZTBU-UHFFFAOYSA-N 0.000 description 1
- 235000007743 myricetin Nutrition 0.000 description 1
- 230000008693 nausea Effects 0.000 description 1
- 239000013642 negative control Substances 0.000 description 1
- 230000036565 night sweats Effects 0.000 description 1
- 206010029410 night sweats Diseases 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 201000008482 osteoarthritis Diseases 0.000 description 1
- 201000008968 osteosarcoma Diseases 0.000 description 1
- 230000036542 oxidative stress Effects 0.000 description 1
- 230000000242 pagocytic effect Effects 0.000 description 1
- 210000000496 pancreas Anatomy 0.000 description 1
- 235000010603 pastilles Nutrition 0.000 description 1
- 230000007170 pathology Effects 0.000 description 1
- 235000020232 peanut Nutrition 0.000 description 1
- 210000003024 peritoneal macrophage Anatomy 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 239000011505 plaster Substances 0.000 description 1
- 239000013641 positive control Substances 0.000 description 1
- 230000035935 pregnancy Effects 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
- 230000000552 rheumatic effect Effects 0.000 description 1
- 206010039073 rheumatoid arthritis Diseases 0.000 description 1
- 235000015067 sauces Nutrition 0.000 description 1
- 201000005113 shigellosis Diseases 0.000 description 1
- 210000000813 small intestine Anatomy 0.000 description 1
- 210000002460 smooth muscle Anatomy 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 210000003699 striated muscle Anatomy 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 230000001502 supplementing effect Effects 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 210000004243 sweat Anatomy 0.000 description 1
- 210000001258 synovial membrane Anatomy 0.000 description 1
- 238000002626 targeted therapy Methods 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 230000035922 thirst Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 230000036269 ulceration Effects 0.000 description 1
- 238000002604 ultrasonography Methods 0.000 description 1
- 208000010570 urinary bladder carcinoma Diseases 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 208000008281 urolithiasis Diseases 0.000 description 1
- 210000004291 uterus Anatomy 0.000 description 1
- 231100000889 vertigo Toxicity 0.000 description 1
- 230000009278 visceral effect Effects 0.000 description 1
- 239000011800 void material Substances 0.000 description 1
- 239000002023 wood Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9068—Zingiber, e.g. garden ginger
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/618—Molluscs, e.g. fresh-water molluscs, oysters, clams, squids, octopus, cuttlefish, snails or slugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
- A61K35/646—Arachnids, e.g. spiders, scorpions, ticks or mites
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/21—Amaranthaceae (Amaranth family), e.g. pigweed, rockwort or globe amaranth
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/236—Ligusticum (licorice-root)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/36—Caryophyllaceae (Pink family), e.g. babysbreath or soapwort
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/40—Cornaceae (Dogwood family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/42—Cucurbitaceae (Cucumber family)
- A61K36/428—Trichosanthes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/47—Euphorbiaceae (Spurge family), e.g. Ricinus (castorbean)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/486—Millettia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/488—Pueraria (kudzu)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/52—Juglandaceae (Walnut family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
- A61K36/804—Rehmannia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/84—Valerianaceae (Valerian family), e.g. valerian
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
- A61K36/8888—Pinellia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Biotechnology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Alternative & Traditional Medicine (AREA)
- Engineering & Computer Science (AREA)
- Insects & Arthropods (AREA)
- Tropical Medicine & Parasitology (AREA)
- Dermatology (AREA)
- Marine Sciences & Fisheries (AREA)
- Zoology (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a kind of external application anti-tumor Chinese medicine cream, contained component raw material is：Fructus Corni, cultivated land, the Radix Astragali, Ligusticum wallichii, the root of kudzu vine, mistletoe, ginger, the tuber of pinellia, the root bark of tree peony, lopseed, peach kernel, cattail pollen, the seed of cowherb, reticulate millettia, oyster, manchurian walnut bark, scorpio, radix cyathulae, Snakegourd Fruit, the Chinese bulbul, Chinese actinidia root, maggot, tangerine leaf, dried orange peel, purslane, field pennycress, akebi, borneol, honey-fried licorice root.External application anti-tumor Chinese medicine cream provided by the invention, which need to only be applied to affected part, can alleviate pain caused by cancer, mitigate the complication such as hydrothorax, ascites, suppress tumor cell proliferation, promote apoptosis of tumor cells, remove necrosis and promote granulation, damaged tissue repair is easy to use, gastrointestinal reaction caused by oral drugs is avoided, the treatment experience of patient can be significantly improved.
Description
Technical field
The present invention relates to a kind of Chinese medicine, and in particular to a kind of external application anti-tumor Chinese medicine cream.
Background technology
Malignant tumour has become one of underlying cause of death in global range.Counted according to the World Health Organization, 2008 because
The patient of tumor mortality is about 7,600,000 people, accounts for the 13% of general mortality rate, it is contemplated that will be up to 11,000,000 to the year two thousand thirty death toll
People.At present, treating the method for tumour mainly includes operation, chemotherapy, radiotherapy and Biological target therapy, and cure rate is few, also simultaneously
Produce great side effect.Some cancers can operative treatment, and can only use medicine for inoperable cancer patient
Thing is treated, to extend the life of patient.
The side effect of chemical synthetic drug is larger, and late result is bad, is not easy long-term use, to some stomach patient or liver
Renal insufficiency person requires to use with caution.Much results of study prove, some simples, the compound preparation of Chinese medicine, there is enhancing to be immunized,
Antitumor, anti-rotation shifting, anti-recurrence, analgesia, elimination malignant hydrothorax, elimination chemicotherapy and molecular targeted agents treatment toxicity,
Improve the effect of function.These discoveries have fully been applied in Chinese medicine cancer at present, and ensure treatment cancer
The effect of disease.Main component as contained by Chinese medicine arsenic is arsenic trioxide, confirms that treatment is white in laboratory and clinic
Blood disease is largely effective.Chinese medicine Liuwei Dihuang Wan is it is verified that be remarkably improved the immunologic function of tumor patient for another example, and
There is protective effect to Bone Marrow of Patients.
In recent years, traditional Chinese medicine antineoplaston turns into clinical research focus.Chinese traditional treatment cancer early in《Interior warp》In
Just on the books in doctor's document, the effect of Chinese medicine is to improve the immunity of cancer patient, so as to play suppression cancer cell multiplication and kill
The effect of dead cancer cell, the advantage such as have good effect, hypotoxicity, medicine source wide.Soft tissue malignant tumour refers to originate from mucous membrane, fine
Dimension, fat, smooth muscle, striated muscle, mesothelium, synovial membrane, blood vessel and are located at soft group of product position (internal organ at the mesenchymal tissue such as lymphatic vessel
Except organ) malignant tumour.Sarcoma can betide the soft tissue of whole body everywhere such as fibrosarcoma, lipoma, liomyoma, leaching
The ratio between the soft group of product malignant tumour such as hand shaft sarcoma and good dangerous tumour are about 5:1.The incidence of disease of Malignant soft tissue sarcoma is 0.7/10
Between ten thousand -1.85/10 ten thousand, the 0.73%-0.81% of whole tumours is accounted for.Soft tissue sarcoma is about twice of osteosarcoma, between good danger
The ratio about 100 of mesenchymal knurl and pernicious mesenchymoma:1.Therefore the target spot that can go directly is researched and developed, the external application for soft tissue malignant tumour resists
Tumour medicine is significant.
The content of the invention
In view of the deficiency of existing antineoplastic, the present invention provides small a kind of curative effect ideal, toxic side effect, short treating period, energy
The external application anti-tumor Chinese medicine cream of Quality of Life of Patients with Tumor is significantly improved, concrete technical scheme is as follows：
A kind of external application anti-tumor Chinese medicine cream, contained component raw material and its parts by weight are：Fructus Corni 10-15 parts, cultivated land 20-
30 parts, Radix Astragali 10-20 parts, Ligusticum wallichii 10-15 parts, root of kudzu vine 10-15 parts, mistletoe 4-8 parts, ginger 10-15 parts, tuber of pinellia 15-20 parts,
Root bark of tree peony 15-20 parts, lopseed 6-10 parts, peach kernel 10-15 parts, cattail pollen 6-10 parts, seed of cowherb 5-10 parts, reticulate millettia 6-10 parts,
Oyster 10-20 parts, manchurian walnut bark 3-9 parts, scorpio 3-5 parts, radix cyathulae 4-8 parts, Snakegourd Fruit 12-15 parts, Chinese bulbul 3-9 parts, Chinese gooseberry
Root 15-20 parts, maggot 6-15 parts, tangerine leaf 10-15 parts, dried orange peel 10-15 parts, purslane 2-6 parts, field pennycress 2-6 parts, akebi 3-
4 parts, borneol 10-15 parts, honey-fried licorice root 6-10 parts.
Preferably, a kind of external application anti-tumor Chinese medicine cream, contained component raw material and its parts by weight are：Fructus Corni 11-14 parts,
Cultivated land 24-26 parts, Radix Astragali 14-16 parts, Ligusticum wallichii 12-14 parts, root of kudzu vine 12-14 parts, mistletoe 5-7 parts, ginger 12-14 parts, the tuber of pinellia
16-18 parts, root bark of tree peony 16-18 parts, lopseed 7-9 parts, peach kernel 12-14 parts, cattail pollen 7-9 parts, seed of cowherb 6-9 parts, reticulate millettia 7-9
Part, oyster 14-16 parts, manchurian walnut bark 5-7 parts, scorpio 3.5-4.5 parts, radix cyathulae 5-7 parts, Snakegourd Fruit 13-15 parts, Chinese bulbul 5-8
Part, Chinese actinidia root 16-19 parts, maggot 8-13 parts, tangerine leaf 12-14 parts, dried orange peel 12-14 parts, purslane 3-5 parts, field pennycress 3-5
Part, akebi 3.2-3.8 parts, borneol 12-14 parts, honey-fried licorice root 7-9 parts.
Preferably, a kind of external application anti-tumor Chinese medicine cream, contained component raw material and its parts by weight are：It is 13 parts of Fructus Corni, ripe
25 parts of ground, 15 parts of the Radix Astragali, 13 parts of Ligusticum wallichii, 13 parts of the root of kudzu vine, 6 parts of mistletoe, 13 parts of ginger, 17 parts of the tuber of pinellia, 17 parts of the root bark of tree peony, lopseed
8 parts, 13 parts of peach kernel, 8 parts of cattail pollen, 7 parts of the seed of cowherb, 8 parts of reticulate millettia, 15 parts of oyster, 6 parts of manchurian walnut bark, 4 parts of scorpio, river ox
6 parts of knee, 14 parts of Snakegourd Fruit, 6 parts of the Chinese bulbul, 17 parts of Chinese actinidia root, 10 parts of maggot, 13 parts of tangerine leaf, 13 parts of dried orange peel, 4 parts of purslane, lose
4 parts of sauce grass, 3.6 parts of akebi, 13 parts of borneol, 8 parts of honey-fried licorice root.
A kind of preparation method of external application anti-tumor Chinese medicine cream, comprises the following steps：
Step 1: the Fructus Corni of parts by weight needed for weighing, cultivated land, the Radix Astragali, Ligusticum wallichii, the root of kudzu vine, mistletoe, ginger, the tuber of pinellia,
The root bark of tree peony, lopseed, cattail pollen, the seed of cowherb, reticulate millettia, manchurian walnut bark, scorpio, radix cyathulae, Snakegourd Fruit, the Chinese bulbul, Chinese actinidia root, five cereals
Worm, tangerine leaf, dried orange peel, purslane, field pennycress, akebi, borneol, honey-fried licorice root cross 150 mesh sieves after crushing, standby；
Step 2: oyster is forged into 2.5h in 550 DEG C in stove, forge rear vinegar and quench, fine grinding is standby into fine powder；Peach kernel is smashed to pieces, obtains peach
Benevolence is broken standby；
Step 3: by the Fructus Corni after crushing, cultivated land, the Radix Astragali, Ligusticum wallichii, the root of kudzu vine, mistletoe, ginger, the tuber of pinellia, the root bark of tree peony, thoroughly
It is bone grass, the seed of cowherb, reticulate millettia, manchurian walnut bark, scorpio, radix cyathulae, Snakegourd Fruit, the Chinese bulbul, Chinese actinidia root, maggot, tangerine leaf, old
Skin, purslane, field pennycress, akebi, borneol, honey-fried licorice root add water to cook 3 times, and the weight of added water is 2-4 times of medicinal powder weight, often
Secondary decoction 1-4h, merging filtrate, filter residue dry and crushed at random with super fine, cross 400 mesh sieves；
Step 4: gained filtrate is concentrated into relative density 1.2, add that ostreae testa pulverata, peach kernel be broken, cattail pollen powder, with filter residue powder,
The borneol of corresponding parts by weight is well mixed to be produced.
The traditional Chinese medical science thinks that malignant tumour is in machine by the internal and external factor long term such as the diseases caused by external factors six external factors which cause diseases, internal damage by the excessive seven emotions, improper diet and overtiredness
Body, makes visceral dysfunction, qi depression to blood stasis, raw in cancer poison, a kind of complex disease caused by healthy tendency damage.It is although each specific
The tumour of internal organs organ has the characteristics of respective, and symptom is different, but evil poison knot, and interweave comprehensive mistake, simulataneous insufficiency and excessive, a variety of pathology
It is its common feature that factor exists simultaneously.
It is considered herein that antitumor will should not be limited to cancerous tumors in itself from the overall condition of patient, propose
The rules for the treatment of of " strengthening vital QI to eliminate pathogenic factors, promoting blood circulation and removing blood stasis, promoting the circulation of qi dissipating bind, promoting diuresis to remove toxic substance ", by tonifying the liver and kidney with righting reinforcing, consolidate human body,
It is promoting blood circulation and removing blood stasis that with promoting blood circulation, clearing and activating the channels and collaterals, for promoting the circulation of qi dissipating bind with eliminating evil softening hard masses, promoting diuresis to remove toxic substance captures cancer poison with heat-clearing and damp-drying drug, from
And making function normal, equilibrium between yin and yang, healthy tendency is vigorous, and qi and blood is orderly and clearly, and exopathogen is difficult to invade, and interior heresy is difficult to produce, then tumour
It must disappear.
Fructus Corni, cultivated land tonify the liver and kidney in the prescription of the present invention, nourishing yin and nourishing blood, radix cyathulae promoting blood circulation, this three's righting
Eliminating evil is monarch drug in a prescription；
Mistletoe wind-damp dispelling, filling liver kidney, strengthening the bones and muscles, principal drug assistance tonifies the liver and kidney, righting reinforcing；The root bark of tree peony is promoting blood circulation and removing blood stasis, peach kernel
Promoting blood circulation, seed of cowherb invigorate blood circulation, mistletoe and reticulate millettia compatibility, raw muscle promoting blood circulation, this plays work(promoting blood circulation and removing blood stasis altogether；
Radix Astragali invigorating qi for strengthening superficies, Ligusticum wallichii blood-activating and qi-promoting, tonification and purgation in combination, abolishes qi depression to blood stasis；The root of kudzu vine plays the role of elevating the spleen-qi, dried orange peel qi-regulating
Invigorating the spleen, it can be replenished qi to invigorate the spleen with use both this；Oyster checking exuberance of yang tonifying yin, softening and resolving hard mass, scorpio dispersing pathogen accumulation, remove obstruction in channels to relieve pain；This 11
Kind of Chinese medicine tonifies the liver and kidney, on the basis of promoting blood circulation in auxiliary monarch drug in a prescription, play softening and resolving hard mass disappear knurl the effect of so that mechanism of qi is smooth
Reach, blood vessels tonneau, be ministerial drug；
Ginger relieving exterior syndrome and dispelling cold, tuber of pinellia dissolving lump and resolving mass, Snakegourd Fruit relieving stuffiness of the chest by dispersing aggregation of pathogens, tangerine leaf is soothing the liver, promoting the circulation of qi, detumescence poison, this is same
With, enhancing ministerial drug softening and resolving hard mass disappear knurl the effect of；Maggot heat-clearing disappears stagnant, and stomach disperse accumulations, and anti-eliminating evil wound is just；It is manchurian walnut bark, white
Head father-in-law, Chinese actinidia root are clearing heat and detoxicating, lopseed dispelling wind and eliminating dampness, removing toxic substances analgesic, promoting blood circulation and stopping pain, and this takes the work(of its sharp gas of invigorating blood circulation, vim and vigour
No pain by smooth breath；Purslane clearing heat and promoting diuresis, removing pattogenic heat from the blood and toxic material from the body, cattail pollen stagnation resolvation, treating stranguria, field pennycress is clearing heat and detoxicating, the carbuncle that disappears apocenosis, promoting blood circulation row
The stasis of blood, akebi inducing diuresis for treating strangurtia, relieving restlessness that clears away heart-fire, this ten threes cooling blood and relieving pain, promoting diuresis to remove toxic substance, the work(of detoxication and toxicant eliminating function is played altogether, is adjutant；
Borneol swelling and pain relieving, resuscitation with aromatics, promote the absorption of medicine, radix glycyrrhizae tonifying spleen and stomach, the root of kudzu vine, dried orange peel QI invigorating can be helped to be good for
Spleen bowl spares, again can coordinating the drug actions of a prescription, the two is makes medicine.
External application anti-tumor Chinese medicine cream provided by the invention is under guidance of traditional Chinese medicine theory, in combination with modern pharmacological research
The side's of sending medication, the scientific compatibility obtained on a large amount of practical basis, emphasis is integrally-regulated, by warming kidney and enhancing body, replenishes qi to invigorate the spleen and
Righting reinforcing, promoting blood circulation and removing blood stasis, by softening and resolving hard mass, clearing damp and promoting diuresis is clearing heat and detoxicating with eliminating evil toxin expelling, so that equilibrium between yin and yang, dirty
Internal organs lifting is orderly, and mechanism of qi is fluent, blood vessels tonneau, ascending the clear and descending the turbid, and damp evil must be removed, and ecchymosis obtains gram, and tumour must disappear.
It can pass through transfer containing abundant polysaccharide, these polysaccharide in the Radix Astragali, cultivated land, the root bark of tree peony, purslane used in the present invention
With enhancing body amynologic mechanism and reach suppress or kill tumour cell purpose.Dihuang polysaccharide is antitumor effective in vivo
The expression of the positive regulating gene-c-fos genes in Lewis lung cancer cells can be made substantially increase under dosage, negative regulator gene-
C-myc gene expressions significantly reduce, and show that Dihuang polysaccharide has a significant effect to oncogene expression.Polysaccharide from Portulaca oleracea can suppress
SMMC7721 liver cancer cells in-vitro multiplications, its cancer resistant effect are in into related to dosage；Polysaccharide from Portulaca oleracea is to mouse S180Solid tumor and
Ascites tumor is all inhibited, can partly prevent S180Cell enters division stage.
There is gentle induced tumors necrosin (TNF) to produce and make mouse peritoneal macrophage thin for the root of kudzu vine used in the present invention
The effect of the phagocytic function enhancing of born of the same parents.The Apoptosis path of myricetin prevention oxidative stress induction is contained by manchurian walnut bark used
PI3K/AKT and MAPK, hesperetin are then the promising antitumor natural aromatic enzyme agent of tool.The Chinese bulbul contained by the Chinese bulbul used
Saponin(e inside and outside is respectively provided with good antitumor activity, by regulating and controlling Akt albumen and its introductory path member, and then induced tumor
Apoptosis, autophagy, the energetic supersession of regulation tumour cell play antitumor action.Maggot institute used fatty acids have in vitro
There is good antitumor activity.Active ingredient saponin(e can significantly induce Hela and Mcf-7 cells to wither in field pennycress used
Die, there is obvious extracorporeal anti-tumor function.
The dosage and the course for the treatment of of external application anti-tumor Chinese medicine cream of the present invention can be made according to patient age, affected part area, light and heavy degree
Go out appropriate adjustment, it is daily 1-3 times, a thin layer is uniformly smeared in affected part, 1 month is a course for the treatment of, and multiple courses for the treatment of can be used continuously.
Each raw material pharmacology is as follows in Chinese medicine preparation of the present invention：
Fructus Corni：It is sour, puckery, slightly warm in nature；Return liver and kidney channel.Tonify the liver and kidney, puckery smart prevent prolapse.For dizziness and tinnitus, waist and knee acid
Bitterly, impotence and seminal emission, enuresis frequent micturition, under uterine bleeding band, profuse sweating collapse, Heat Diabetes.
Cultivated land：It is sweet, slightly warm in nature；Return liver and kidney channel；Nourishing yin and supplementing blood, beneficial to spirit and marrow.For the deficiency of liver-yin and kidney-yin, soreness and weakness of waist and knees, bone
Steam hectic fever, night sweat seminal emission, Heat Diabetes, blood deficiency chlorosis, palpitation and severe palpitation, irregular menstruation, metrostaxis, dizziness, tinnitus, beard and hair morning
In vain.
The Radix Astragali：It is sweet, slightly warm in nature；Invigorating qi for strengthening superficies, torr sore myogenic.Cure mainly physically weak spontaneous perspiration, chronic diarrhea, prolapse of the anus, the prolapse of uterus, slowly
Property ephritis, physically weak edema, chronic ulcer, the long disunion of the open sore part.
Ligusticum wallichii：Acrid flavour, it is warm-natured；Return liver, courage, pericardium channel.Blood-activating and qi-promoting, wind-expelling pain-stopping.For irregular menstruation, Amenorrhea pain
Through, abdominal mass stomachache, chest side of body shouting pain, tumbling and swelling, headache, arthralgia pain due to rheumatism.
The root of kudzu vine：It is sweet, pungent, it is cool in nature；Returns spleen, stomach.Expelling pathogenic factors from muscles and skin is brought down a fever, and is promoted the production of body fluid, promoting eruption, Shengyang Zhixie.For fever caused by exogenous pathogens
Headache, stiff nape and back, it is thirsty, quench one's thirst, measles without adequate eruption, hot dysentery, diarrhea, hypertension neck pain.
Mistletoe：Bitter, it is mild-natured；Return liver warp, kidney channel.Wind-damp dispelling, filling liver kidney, strengthening the bones and muscles are antiabortive.For arthralgia pain due to rheumatism,
Soreness and weakness of waist and knees, fetal irritability, uterine bleeding pass through more, blood leaking in gestation.
Ginger：Acrid flavour, slightly warm in nature；Return lung, spleen, stomach.Relieving exterior syndrome and dispelling cold, warming middle energizer to arrest vomiting, preventing phlegm from forming and stopping coughing.For chill sense
Emit, gastrofrigid vomiting, cold productive cough is coughed.
The tuber of pinellia：Acrid flavour, it is warm-natured, it is poisonous；Returns spleen, stomach, lung channel.It is eliminating dampness and eliminating phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, dissolving lump and resolving mass.For abundant expectoration
Cough and asthma, phlegm retention anti-dazzle nervous, anemophlegmatic vertigo, phlegm and headache, vomiting gastric disorder causing nausea, chest gastral cavity ruffian, globus hysteriocus；Controlling outward carbuncle swells subcutaneous nodule is used in life.Ginger
The tuber of pinellia is used for stopping nausea and vomiting by lowering the adverse flow of QI.
The root bark of tree peony：Bitter, pungent, cold nature；The thoughts of returning home, liver and kidney channel.Clearing heat and cooling blood, it is promoting blood circulation and removing blood stasis.For febrile virulent maculae, spit blood
Bleeding from five sense organs or subcutaneous tissue, night fever abating at dawn, lossless hectic fever due to yin, closed dysmenorrhea, carbuncle sore tumefacting virus, the pain of injury caused by falling and tumbling.
Lopseed：Acrid flavour, hardship, it is warm-natured；It is slightly poisonous.Return liver and kidney channel.Dispelling wind and eliminating dampness, removing toxic substances analgesic.For rheumatoid arthrosis
Bitterly；Sore swollen toxin is controlled in external application.
Peach kernel：It is bitter, sweet, it is mild-natured；The thoughts of returning home, liver, large intestine channel.Promoting blood circulation, relax bowel.For Amenorrhea, dysmenorrhoea , wei lumps in the abdomen
Lump in the abdomen, injury from falling down, dry constipation of intestines.
Cattail pollen：It is sweet, it is mild-natured；Return liver, pericardium channel.Hemostasis, stagnation resolvation is treating stranguria.For spitting blood, bleeding from five sense organs or subcutaneous tissue, spitting of blood, uterine bleeding, outside
Hinder bleeding, closed dysmenorrhea, gastral cavity abdomen shouting pain, tumbling and swelling, blood strangury and dry pain.
The seed of cowherb：Bitter, it is mild-natured；Return liver, stomach.Invigorate blood circulation, lower breast detumescence.For agalactia, Amenorrhea, pain
Through acute mastitis swelling and pain.
Reticulate millettia：It is bitter, sweet, it is warm-natured；Return liver and kidney channel.Enrich blood, invigorate blood circulation, dredging collateral.For irregular menstruation, blood deficiency chlorosis, fiber crops
Wood paralysis, arthralgia pain due to rheumatism.
Oyster：Taste is salty, cold nature；Return liver, courage, kidney channel.It is transquilization with heavy material, checking exuberance of yang tonifying yin, softening and resolving hard mass.Lost for palpitating with fear
Sleep, dizziness and tinnitus, scrofula subcutaneous nodule, abdominal mass lump in the abdomen.Calcined oyster shell convergence is astringent or styptic treatment for spontaneous sweating.For spontaneous sweating, band is collapsed in seminal emission, acid regurgitation of having a stomachache.
Manchurian walnut bark：It is bitter in taste, tremble with fear.Heat-clearing, removing toxic substances, stop dysentery, improving eyesight.For diarrhea, dysentery, leukorrhea, hot eyes.
Scorpio：Acrid flavour, it is mild-natured, it is poisonous；Return liver warp.Ceases wind antispastic, dispersing pathogen accumulation, removes obstruction in channels to relieve pain.For child convulsion, take out
Jerk spasm, middle air port is askew, hemiplegia, lockjaw, rheumatoid arthritis stubborn, migraine and general headache, sore, scrofula.
Radix cyathulae：Sweet, slight bitter, it is mild-natured；Return liver and kidney channel.Promoting blood circulation；Expelling wind and removing dampness.Main blood stasis；Difficult labour；Born of the same parents
Clothing not under；Postpartum blood stasis is suffered from abdominal pain；Heat gonorrhea；Urolithiasis；Dysmenorrhoea；Rheumatism lumbocrural pain.
Snakegourd Fruit：Sweet, slight bitter, it is cold in nature；Return lung, stomach, large intestine channel.Clearing away heat and eliminating phlegm, relieving stuffiness of the chest by dispersing aggregation of pathogens, moisturize laxation.For lung
Heat cough, the turbid Huang of phlegm is thick, chest impediment and cardialgia, accumulation of pathogens in chest feeling of fullness, acute mastitis, lung carbuncle, acute appendicitis swelling and pain, constipation.
The Chinese bulbul：Bitter, it is cold in nature；Return stomach, large intestine channel.It is clearing heat and detoxicating, remove heat from the blood and relieve diarrhea.For toxic-heat and blood stasis, under pruritus vulvae band,
Amebic dysentery.
Chinese actinidia root：It is sour, puckery, it is cool in nature；It is clearing heat and detoxicating, dispelling wind and eliminating dampness, diuresis hemostasis.For treating rheumatic ostealgia, and jaundice
Deng disease.
Maggot：Taste is salty, cold in nature；Enter spleen, stomach.Heat-clearing, disappear stagnant.Control infantile malnutrition due to digestive disturbances or intestinalparasites abdominal distension, infantile malnutrition due to digestive disturbances or intestinalparasites sore.
Tangerine leaf：It is bitterly, it is mild-natured；It is soothing the liver, promoting the circulation of qi, resolving sputum, detumescence poison.Control hypochondriac pain, acute mastitis, lung carbuncle, cough, chest diaphragm ruffian
It is full, hernia.
Dried orange peel：It is bitter, pungent, it is warm-natured；Return lung, the spleen channel.Regulating qi-flowing for strengthening spleen is eliminating dampness and eliminating phlegm.For chest gastral cavity turgor, deficiency of food is vomited and diarrhoea,
Coughing with a lot of sputum.
Purslane：It is sour, it is cold in nature；Clearing heat and promoting diuresis, removing pattogenic heat from the blood and toxic material from the body.For bacillary dysentery, acute gastroenteritis, acute appendix
Inflammation, mastitis, hemorrhoid hemorrhage, leukorrhea；Furuncle swelling toxin, eczema, herpes zoster are controlled in external application.
Field pennycress：Acrid flavour, hardship, it is cool in nature；Return stomach, large intestine, Liver Channel.It is clearing heat and detoxicating, the carbuncle that disappears apocenosis, blood circulation promoting competent silt.For intestines
Carbuncle, lung carbuncle and sore and toxic, the disease such as chest and abdomen pain, postpartum stasis of blood caused by the real heat stasis of blood is stagnant.
Akebi：Bitter, it is cold in nature.The thoughts of returning home, small intestine, bladder warp.Inducing diuresis for treating strangurtia, relieving restlessness that clears away heart-fire, stimulate the menstrual flow lower breast.For stranguria,
Oedema, red, the aphthae of vexed urine, Amenorrhea breast is few, damp and hot numbness pain.
Borneol：Acrid flavour, hardship, it is cool in nature.The thoughts of returning home, lung channel.Inducing resuscitation of having one's ideas straightened out, radiating analgesic, shade removing.Cure mainly apoplexy lockjaw；
Pyreticosis coma；Frightened epilepsy phlegm fan；Deafness with qi stagnation；Conjunctivitis；Larynx numbness；Aphtha；Carbuncle swells；Hemorrhoid；Enterobiasis.
Radix glycyrrhizae：It is sweet, it is mild-natured.The thoughts of returning home, lung, spleen, stomach.It is clearing heat and detoxicating, cough-relieving apophlegmatic, tonifying spleen and stomach, coordinating the drug actions of a prescription.With
Just let out in insufficiency of the spleen, stomach void is thirsty, cough due to deficiency of the lung, abscess of throat, palpitaition pectoralgia, ulcer sore pain, gastroenteritic ulcer etc..
External application anti-tumor Chinese medicine cream provided by the invention, has the advantages that compared with prior art：
1. the prescription in the present invention obtains on the basis of theory of traditional Chinese medical science with reference to a large amount of concrete practice science, safely may be used
Lean on, acted synergistically between each component, tonification and purgation in combination, by warming kidney and enhancing body, replenishes qi to invigorate the spleen, and promoting blood circulation and removing blood stasis, softening and resolving hard mass, Li Shui oozes
It is wet, it is clearing heat and detoxicating so that equilibrium between yin and yang, internal organs lifting is orderly, and mechanism of qi is fluent, blood vessels tonneau, ascending the clear and descending the turbid, and damp evil must be removed, the stasis of blood
Malicious gram, tumour must disappear, and can alleviate pain caused by cancer, improve patient's body's immunity, stable knurl body, improve symptom, make cancer patient
Significantly improve life quality, extend life cycle.
2. the preparation method of external application anti-tumor Chinese medicine cream provided by the invention, maximum according to the property of each medicine in prescription
Antitumor active ingredient in degree extraction medicine, while the pharmacological action of comedicine is more given full play to, during gained external application is antitumor
Ointment, which need to only be applied to affected part, can alleviate pain caused by cancer, mitigate the complication such as hydrothorax, ascites, suppress tumor cell proliferation, promote swollen
Apoptosis of tumor, remove necrosis and promote granulation, damaged tissue repair is easy to use, avoids gastrointestinal reaction caused by oral drugs, can be notable
Improve the treatment experience of patient.
3. external application anti-tumor Chinese medicine cream skin-permeable provided by the invention, go directly target spot, promotes microcirculation, passes through channels and collaterals
The vital organs of the human body of human body are acted, the local symptom of patient body-surface malignant tumour can not only be improved, but also can be right
Its whole body health situation is adjusted, and compensate for operation, radiotherapy and the defects of embolic chemotherapy, the labour of patient is influenceed compared with
It is small, can normal life and work, expense is low, and adverse reaction is small.
Embodiment
Further to illustrate the technological means and its effect of the invention taken, below in conjunction with being preferable to carry out for the present invention
Example is described in detail.
Embodiment 1
A kind of external application anti-tumor Chinese medicine cream, contained component raw material and its parts by weight are：10 parts of Fructus Corni, 20 parts of cultivated land,
10 parts of the Radix Astragali, 10 parts of Ligusticum wallichii, 10 parts of the root of kudzu vine, 4 parts of mistletoe, 10 parts of ginger, 15 parts of the tuber of pinellia, 15 parts of the root bark of tree peony, 6 parts of lopseed, peach
10 parts of benevolence, 6 parts of cattail pollen, 5 parts of the seed of cowherb, 6 parts of reticulate millettia, 10 parts of oyster, 3 parts of manchurian walnut bark, 3 parts of scorpio, 4 parts of radix cyathulae,
12 parts of Snakegourd Fruit, 3 parts of the Chinese bulbul, 15 parts of Chinese actinidia root, 6 parts of maggot, 10 parts of tangerine leaf, 10 parts of dried orange peel, 2 parts of purslane, field pennycress 2
Part, 3 parts of akebi, 10 parts of borneol, 6 parts of honey-fried licorice root.
A kind of preparation method of external application anti-tumor Chinese medicine cream, comprises the following steps：
Step 1: the Fructus Corni of parts by weight needed for weighing, cultivated land, the Radix Astragali, Ligusticum wallichii, the root of kudzu vine, mistletoe, ginger, the tuber of pinellia,
The root bark of tree peony, lopseed, cattail pollen, the seed of cowherb, reticulate millettia, manchurian walnut bark, scorpio, radix cyathulae, Snakegourd Fruit, the Chinese bulbul, Chinese actinidia root, five cereals
Worm, tangerine leaf, dried orange peel, purslane, field pennycress, akebi, borneol, honey-fried licorice root cross 150 mesh sieves after crushing, standby；
Step 2: oyster is forged into 2.5h in 550 DEG C in stove, forge rear vinegar and quench, fine grinding is standby into fine powder；Peach kernel is smashed to pieces, obtains peach
Benevolence is broken standby；
Step 3: by the Fructus Corni after crushing, cultivated land, the Radix Astragali, Ligusticum wallichii, the root of kudzu vine, mistletoe, ginger, the tuber of pinellia, the root bark of tree peony, thoroughly
It is bone grass, the seed of cowherb, reticulate millettia, manchurian walnut bark, scorpio, radix cyathulae, Snakegourd Fruit, the Chinese bulbul, Chinese actinidia root, maggot, tangerine leaf, old
Skin, purslane, field pennycress, akebi, borneol, honey-fried licorice root add water to cook 3 times, and the weight of added water is 2 times of medicinal powder weight, every time
1h, merging filtrate are decocted, filter residue dries and crushed at random with super fine, crosses 400 mesh sieves；
Step 4: gained filtrate is concentrated into relative density 1.2, add that ostreae testa pulverata, peach kernel be broken, cattail pollen powder, with filter residue powder,
The borneol of corresponding parts by weight is well mixed to be produced.
Embodiment 2
A kind of external application anti-tumor Chinese medicine cream, contained component raw material and its parts by weight are：11 parts of Fructus Corni, 21 parts of cultivated land,
11 parts of the Radix Astragali, 11 parts of Ligusticum wallichii, 11 parts of the root of kudzu vine, 5 parts of mistletoe, 11 parts of ginger, 16 parts of the tuber of pinellia, 16 parts of the root bark of tree peony, 7 parts of lopseed, peach
11 parts of benevolence, 7 parts of cattail pollen, 6 parts of the seed of cowherb, 7 parts of reticulate millettia, 11 parts of oyster, 4 parts of manchurian walnut bark, 3.2 parts of scorpio, radix cyathulae 5
Part, 13 parts of Snakegourd Fruit, 4 parts of the Chinese bulbul, 16 parts of Chinese actinidia root, 7 parts of maggot, 11 parts of tangerine leaf, 11 parts of dried orange peel, 3 parts of purslane, field pennycress
3 parts, 4 parts of akebi, 11 parts of borneol, 7 parts of honey-fried licorice root.
A kind of preparation method of external application anti-tumor Chinese medicine cream, comprises the following steps：
Step 1: the Fructus Corni of parts by weight needed for weighing, cultivated land, the Radix Astragali, Ligusticum wallichii, the root of kudzu vine, mistletoe, ginger, the tuber of pinellia,
The root bark of tree peony, lopseed, cattail pollen, the seed of cowherb, reticulate millettia, manchurian walnut bark, scorpio, radix cyathulae, Snakegourd Fruit, the Chinese bulbul, Chinese actinidia root, five cereals
Worm, tangerine leaf, dried orange peel, purslane, field pennycress, akebi, borneol, honey-fried licorice root cross 150 mesh sieves after crushing, standby；
Step 2: oyster is forged into 2.5h in 550 DEG C in stove, forge rear vinegar and quench, fine grinding is standby into fine powder；Peach kernel is smashed to pieces, obtains peach
Benevolence is broken standby；
Step 3: by the Fructus Corni after crushing, cultivated land, the Radix Astragali, Ligusticum wallichii, the root of kudzu vine, mistletoe, ginger, the tuber of pinellia, the root bark of tree peony, thoroughly
It is bone grass, the seed of cowherb, reticulate millettia, manchurian walnut bark, scorpio, radix cyathulae, Snakegourd Fruit, the Chinese bulbul, Chinese actinidia root, maggot, tangerine leaf, old
Skin, purslane, field pennycress, akebi, borneol, honey-fried licorice root add water to cook 3 times, and the weight of added water is 2.5 times of medicinal powder weight, often
Secondary decoction 2h, merging filtrate, filter residue dry and crushed at random with super fine, cross 400 mesh sieves；
Step 4: gained filtrate is concentrated into relative density 1.2, add that ostreae testa pulverata, peach kernel be broken, cattail pollen powder, with filter residue powder,
The borneol of corresponding parts by weight is well mixed to be produced.
Embodiment 3
A kind of external application anti-tumor Chinese medicine cream, contained component raw material and its parts by weight are：13 parts of Fructus Corni, 25 parts of cultivated land,
15 parts of the Radix Astragali, 13 parts of Ligusticum wallichii, 13 parts of the root of kudzu vine, 6 parts of mistletoe, 13 parts of ginger, 17 parts of the tuber of pinellia, 17 parts of the root bark of tree peony, 8 parts of lopseed, peach
13 parts of benevolence, 8 parts of cattail pollen, 7 parts of the seed of cowherb, 8 parts of reticulate millettia, 15 parts of oyster, 6 parts of manchurian walnut bark, 4 parts of scorpio, 6 parts of radix cyathulae,
14 parts of Snakegourd Fruit, 6 parts of the Chinese bulbul, 17 parts of Chinese actinidia root, 10 parts of maggot, 13 parts of tangerine leaf, 13 parts of dried orange peel, 4 parts of purslane, field pennycress 4
Part, 3.6 parts of akebi, 13 parts of borneol, 8 parts of honey-fried licorice root.
A kind of preparation method of external application anti-tumor Chinese medicine cream, comprises the following steps：
Step 1: the Fructus Corni of parts by weight needed for weighing, cultivated land, the Radix Astragali, Ligusticum wallichii, the root of kudzu vine, mistletoe, ginger, the tuber of pinellia,
The root bark of tree peony, lopseed, cattail pollen, the seed of cowherb, reticulate millettia, manchurian walnut bark, scorpio, radix cyathulae, Snakegourd Fruit, the Chinese bulbul, Chinese actinidia root, five cereals
Worm, tangerine leaf, dried orange peel, purslane, field pennycress, akebi, borneol, honey-fried licorice root cross 150 mesh sieves after crushing, standby；
Step 2: oyster is forged into 2.5h in 550 DEG C in stove, forge rear vinegar and quench, fine grinding is standby into fine powder；Peach kernel is smashed to pieces, obtains peach
Benevolence is broken standby；
Step 3: by the Fructus Corni after crushing, cultivated land, the Radix Astragali, Ligusticum wallichii, the root of kudzu vine, mistletoe, ginger, the tuber of pinellia, the root bark of tree peony, thoroughly
It is bone grass, the seed of cowherb, reticulate millettia, manchurian walnut bark, scorpio, radix cyathulae, Snakegourd Fruit, the Chinese bulbul, Chinese actinidia root, maggot, tangerine leaf, old
Skin, purslane, field pennycress, akebi, borneol, honey-fried licorice root add water to cook 3 times, and the weight of added water is 3 times of medicinal powder weight, every time
3h, merging filtrate are decocted, filter residue dries and crushed at random with super fine, crosses 400 mesh sieves；
Step 4: gained filtrate is concentrated into relative density 1.2, add that ostreae testa pulverata, peach kernel be broken, cattail pollen powder, with filter residue powder,
The borneol of corresponding parts by weight is well mixed to be produced.
Embodiment 4
A kind of external application anti-tumor Chinese medicine cream, contained component raw material and its parts by weight are：15 parts of Fructus Corni, 30 parts of cultivated land,
20 parts of the Radix Astragali, 15 parts of Ligusticum wallichii, 15 parts of the root of kudzu vine, 8 parts of mistletoe, 15 parts of ginger, 20 parts of the tuber of pinellia, 20 parts of the root bark of tree peony, 10 parts of lopseed, peach
15 parts of benevolence, 10 parts of cattail pollen, 10 parts of the seed of cowherb, 10 parts of reticulate millettia, 20 parts of oyster, 9 parts of manchurian walnut bark, 5 parts of scorpio, radix cyathulae 8
Part, 15 parts of Snakegourd Fruit, 9 parts of the Chinese bulbul, 20 parts of Chinese actinidia root, 15 parts of maggot, 15 parts of tangerine leaf, 15 parts of dried orange peel, 6 parts of purslane, Patrinia scaniosaefolia
6 parts of grass, 4 parts of akebi, 15 parts of borneol, 10 parts of honey-fried licorice root.
A kind of preparation method of external application anti-tumor Chinese medicine cream, comprises the following steps：
Step 1: the Fructus Corni of parts by weight needed for weighing, cultivated land, the Radix Astragali, Ligusticum wallichii, the root of kudzu vine, mistletoe, ginger, the tuber of pinellia,
The root bark of tree peony, lopseed, cattail pollen, the seed of cowherb, reticulate millettia, manchurian walnut bark, scorpio, radix cyathulae, Snakegourd Fruit, the Chinese bulbul, Chinese actinidia root, five cereals
Worm, tangerine leaf, dried orange peel, purslane, field pennycress, akebi, borneol, honey-fried licorice root cross 150 mesh sieves after crushing, standby；
Step 2: oyster is forged into 2.5h in 550 DEG C in stove, forge rear vinegar and quench, fine grinding is standby into fine powder；Peach kernel is smashed to pieces, obtains peach
Benevolence is broken standby；
Step 3: by the Fructus Corni after crushing, cultivated land, the Radix Astragali, Ligusticum wallichii, the root of kudzu vine, mistletoe, ginger, the tuber of pinellia, the root bark of tree peony, thoroughly
It is bone grass, the seed of cowherb, reticulate millettia, manchurian walnut bark, scorpio, radix cyathulae, Snakegourd Fruit, the Chinese bulbul, Chinese actinidia root, maggot, tangerine leaf, old
Skin, purslane, field pennycress, akebi, borneol, honey-fried licorice root add water to cook 3 times, and the weight of added water is 4 times of medicinal powder weight, every time
4h, merging filtrate are decocted, filter residue dries and crushed at random with super fine, crosses 400 mesh sieves；
Step 4: gained filtrate is concentrated into relative density 1.2, add that ostreae testa pulverata, peach kernel be broken, cattail pollen powder, with filter residue powder,
The borneol of corresponding parts by weight is well mixed to be produced.
Embodiment 5
A kind of external application anti-tumor Chinese medicine cream, contained component raw material and its parts by weight are：14 parts of Fructus Corni, 29 parts of cultivated land,
19 parts of the Radix Astragali, 14 parts of Ligusticum wallichii, 14 parts of the root of kudzu vine, 7 parts of mistletoe, 14 parts of ginger, 19 parts of the tuber of pinellia, 19 parts of the root bark of tree peony, 9 parts of lopseed, peach
14 parts of benevolence, 9 parts of cattail pollen, 9 parts of the seed of cowherb, 9 parts of reticulate millettia, 19 parts of oyster, 8 parts of manchurian walnut bark, 4.8 parts of scorpio, radix cyathulae 7
Part, 14 parts of Snakegourd Fruit, 8 parts of the Chinese bulbul, 19 parts of Chinese actinidia root, 14 parts of maggot, 14 parts of tangerine leaf, 14 parts of dried orange peel, 5 parts of purslane, Patrinia scaniosaefolia
5 parts of grass, 3.8 parts of akebi, 14 parts of borneol, 9 parts of honey-fried licorice root.
Its preparation method is same as Example 3.
Embodiment 6
A kind of external application anti-tumor Chinese medicine cream, contained component raw material and its parts by weight are：12 parts of Fructus Corni, 23 parts of cultivated land,
16 parts of the Radix Astragali, 10 parts of Ligusticum wallichii, 15 parts of the root of kudzu vine, 4 parts of mistletoe, 15 parts of ginger, 15 parts of the tuber of pinellia, 20 parts of the root bark of tree peony, 6 parts of lopseed, peach
15 parts of benevolence, 7 parts of cattail pollen, 5 parts of the seed of cowherb, 10 parts of reticulate millettia, 10 parts of oyster, 8 parts of manchurian walnut bark, 3 parts of scorpio, 8 parts of radix cyathulae,
10 parts of Snakegourd Fruit, 5 parts of the Chinese bulbul, 18 parts of Chinese actinidia root, 8 parts of maggot, 15 parts of tangerine leaf, 10 parts of dried orange peel, 6 parts of purslane, field pennycress 5
Part, 3 parts of akebi, 15 parts of borneol, 8 parts of honey-fried licorice root.
Its preparation method is same as Example 3.
Antitumor activity in vitro
Cell line：People's basal-cell carcinoma, squamous cell carcinoma, malignant mela noma, lymthoma, breast cancer, bladder carcinoma strain
There is provided by Henan university of TCM pharmacological evaluation room；
Test method：During 1-3 of the embodiment of the present invention is prepared using tetrazolium bromide reducing process (MTT) external application is antitumor
Ointment carries out antitumor activity in vitro, by people's basal-cell carcinoma, squamous cell carcinoma, malignant mela noma, lymthoma knurl strain pancreas
Enzyme is digested, counted, concentration is made as 5 × 104Individual/mL cell suspension.100 μ L cells will be added in 96 orifice plates per hole to hang
Liquid is (per hole 5 × 103Individual cell), it is subsequently placed in 37 DEG C, 5%CO2Cultivated 24 hours in incubator；Diluted with non-fully culture medium
Medicine adds the 100 corresponding pastille culture mediums of μ L per hole, while set up physiological saline to required same concentrations (10mg/mL)
Negative control group and awei huapi plaster, awei huapi gao positive controls, then 96 orifice plates are placed in 37 DEG C, 5%CO2Cultivated 72 hours in incubator,
Then 20 μ LMTT (5mg/mL) are added per hole, continue culture 4 hours, culture is terminated, discards culture medium, 150 μ are added per hole
LDMSO dissolves, and shaking table gently mixes for 10 minutes.Under λ=4570nm, the wavelength of 620nm two extinction per hole is detected with ELIASA
Degree is OD values, the OD values using the average value of each multiple holes as the cell.Specific test result is as shown in table 1：
Inhibitory action (IC of the external application anti-tumor Chinese medicine cream of table 1 to tumour cell50For half inhibiting rate)
It is thin to kinds of tumors from the antitumor activity in vitro result of table 1, external application anti-tumor Chinese medicine cream provided by the invention
Born of the same parents have stronger inhibitory action, can be used for the treatment of soft tissue malignant tumour's disease.
Clinical practice
Data and method choose the patients with basal cell carcinomas 49 that in December, 2014 in June, 2016, our hospital accepted for medical treatment, pernicious
Melanoma patients 62 and Lymphoma 53, totally 164 soft tissue malignant tumour patients, are divided into according to table of random numbers method
Three groups of operative treatment group and test group, operative treatment group 88, test group 76.The general money such as the sex of two groups of patients, age
Material compares, no significant difference (P ＞ 0.05).Informed consent form is signed with patient, and informs that patient avoids cooperateing with medication.
Operative treatment group is treated surgically plus supportive treatment method；The external application that test group receives the offer of the embodiment of the present invention 3 is antitumor
Traditional Chinese medicinal ointment smears treatment plus supportive treatment.Each group therapeutic process must not use other symptomatic drugs, and treatment time is 28 days.
Observation index observe two groups of patients treated effect, and before and after comparison therapy two groups of patients symptom situation of change
And a situation arises for adverse reaction.
Efficacy determination is 1. effective：Tumour knurl body reduces more than 10%, and cardinal symptom disappears；It is 2. effective：Tumour knurl body reduces 1
~10%, clinical symptoms are obviously improved；It is 3. invalid：Tumour knurl body continues to increase, and clinical symptoms are without improvement or aggravate.
Two groups of tumour knurl body situations and clinical symptoms compare after therapeutic effect treatment, test group compared with operative treatment group,
Total effective rate is higher than operative treatment group.It is shown in Table 2.
Curative effect compares after table 2 is treated
It is 35 that number of cases, which occurs, for the adverse reaction of adverse reaction rate operative treatment group, incidence 39.78%；Test group
Adverse reaction occur number of cases be 11, incidence 14.47%.The bad incidence of test group is less than operative treatment group, difference
Statistically significant (P ＜ 0.05).Operative treatment group patient will bear the painful and huge surgery cost of operation, operation meeting pair
The body and mind of patient is caused compared with major injury, and test group has good effect, expense is low, and adverse reaction is few, bright compared with operative treatment group
The aobvious advantage for improving life in patients.
Clinical test shows that the tumour knurl body of test group and clinical symptoms improve situation and are better than operative treatment group, it is known that implements
The external application anti-tumor Chinese medicine cream that example 4 provides has remarkable result in terms of a variety of soft tissue malignant tumours are treated.
Model case
1. Niu, man, life in 1963, Zhengzhou, henan people, patient has a dun lesser tubercle on the face, before half a year in
Centre starts ulceration, ties black gangrenosum acne scab, and examination in hospital is diagnosed as basal-cell carcinoma, gives external application in its embodiment of the present invention 3
Anti-tumor Chinese medicine cream is treated, and is smeared once daily, the continuous necrosis of skin that medication is festered after two weeks comes off, and faces after three months
Bed is cured, no recurrence.
2. Mr. Wang, female, life in 1974, Hebei people from Hengshui, breast lump, mammary gland pain, axillary gland enlargement, it is diagnosed as
Breast cancer, fear operative treatment, give external application anti-tumor Chinese medicine cream in its embodiment of the present invention 3 and treated, smear breast daily
Room corresponding site 2-3 times, after 3 days, pain relief is continuous to smear 45 days, B ultrasound check tumor disappearance.
3. Zhao so-and-so, man, life in 1980, Nanyang, henan people, the shelled peanut size melanoma of back one, there is infiltration trend,
Hospital is diagnosed as melanoma canceration, and surgery excision knurl body, sterilization is strict, and wound heals quickly, and side is grown again after three months
Two melanomas, patient refuse second operation, select the external application anti-tumor Chinese medicine cream in the embodiment of the present invention 3 to be treated,
Smear twice daily, melanoma reduces gradually after one month, and treat three months again after, melanoma all disappears.
4. Huang, man, life in 1972, Jincheng, Shanxi people, cervical lymph node enlargement, have swallowed pain, with heating, steal
Sweat, regional nodes's knurl is diagnosed as, it is powerless to undertake huge surgery cost because household economy is poverty-stricken, select the embodiment of the present invention 3 to carry
The external application anti-tumor Chinese medicine cream of confession carries out expectant treatment, smears twice, pain relief after one week, is used continuously three months daily,
Knurl body is reduced significantly.
Tested more than and clinical practice, external application anti-tumor Chinese medicine cream provided by the invention have promoting blood circulation, disappeared
The effect of swollen dissipating bind, sharp water toxin expelling, external application can rapid skin permeation, suppress tumor cell proliferation, promote local microcirculation, go corruption
Myogenic, damaged tissues are repaired, can also alleviate pain caused by cancer and chest and abdomen ponding, improve patient's immunity and the state of mind, cost is cheap, no
Good incidence is low, has good application prospect in terms of antineoplaston.
The foregoing is only a specific embodiment of the invention, but protection scope of the present invention is not limited thereto, ability
Other modifications or equivalent substitution that domain those of ordinary skill is made to technical scheme, without departing from skill of the present invention
The spirit and scope of art scheme, it all should cover among scope of the presently claimed invention.
Claims (5)
1. a kind of external application anti-tumor Chinese medicine cream, it is characterised in that contained component raw material and its parts by weight are：Fructus Corni 10-15
Part, cultivated land 20-30 parts, Radix Astragali 10-20 parts, Ligusticum wallichii 10-15 parts, root of kudzu vine 10-15 parts, mistletoe 4-8 parts, ginger 10-15 parts, half
Summer 15-20 part, root bark of tree peony 15-20 parts, lopseed 6-10 parts, peach kernel 10-15 parts, cattail pollen 6-10 parts, seed of cowherb 5-10 parts, chicken blood
Rattan 6-10 parts, oyster 10-20 parts, manchurian walnut bark 3-9 parts, scorpio 3-5 parts, radix cyathulae 4-8 parts, Snakegourd Fruit 12-15 parts, Chinese bulbul 3-
9 parts, Chinese actinidia root 15-20 parts, maggot 6-15 parts, tangerine leaf 10-15 parts, dried orange peel 10-15 parts, purslane 2-6 parts, field pennycress 2-6
Part, akebi 3-4 parts, borneol 10-15 parts, honey-fried licorice root 6-10 parts.
2. a kind of external application anti-tumor Chinese medicine cream according to claim 1, it is characterised in that contained component raw material and its weight
Number is：Fructus Corni 11-14 parts, cultivated land 24-26 parts, Radix Astragali 14-16 parts, Ligusticum wallichii 12-14 parts, root of kudzu vine 12-14 parts, mistletoe 5-
7 parts, ginger 12-14 parts, tuber of pinellia 16-18 parts, root bark of tree peony 16-18 parts, lopseed 7-9 parts, peach kernel 12-14 parts, cattail pollen 7-9 parts, king
Do not stay row 6-9 parts, reticulate millettia 7-9 parts, oyster 14-16 parts, manchurian walnut bark 5-7 parts, scorpio 3.5-4.5 parts, radix cyathulae 5-7 parts,
Snakegourd Fruit 13-15 parts, Chinese bulbul 5-8 parts, Chinese actinidia root 16-19 parts, maggot 8-13 parts, tangerine leaf 12-14 parts, dried orange peel 12-14 parts, horse
Bitterroot 3-5 parts, field pennycress 3-5 parts, akebi 3.2-3.8 parts, borneol 12-14 parts, honey-fried licorice root 7-9 parts.
3. a kind of external application anti-tumor Chinese medicine cream according to claim 1, it is characterised in that contained component raw material and its weight
Number is：13 parts of Fructus Corni, 25 parts of cultivated land, 15 parts of the Radix Astragali, 13 parts of Ligusticum wallichii, 13 parts of the root of kudzu vine, 6 parts of mistletoe, 13 parts of ginger, the tuber of pinellia
17 parts, 17 parts of the root bark of tree peony, 8 parts of lopseed, 13 parts of peach kernel, 8 parts of cattail pollen, 7 parts of the seed of cowherb, 8 parts of reticulate millettia, 15 parts of oyster, walnut
6 parts of Chinese catalpa skin, 4 parts of scorpio, 6 parts of radix cyathulae, 14 parts of Snakegourd Fruit, 6 parts of the Chinese bulbul, 17 parts of Chinese actinidia root, 10 parts of maggot, 13 parts of tangerine leaf,
13 parts of dried orange peel, 4 parts of purslane, 4 parts of field pennycress, 3.6 parts of akebi, 13 parts of borneol, 8 parts of honey-fried licorice root.
4. a kind of preparation method of external application anti-tumor Chinese medicine cream according to claim 1, it is characterised in that including following step
Suddenly：
Step 1: Fructus Corni, cultivated land, the Radix Astragali, Ligusticum wallichii, the root of kudzu vine, mistletoe, ginger, the tuber of pinellia, the pellet of parts by weight needed for weighing
Skin, lopseed, cattail pollen, the seed of cowherb, reticulate millettia, manchurian walnut bark, scorpio, radix cyathulae, Snakegourd Fruit, the Chinese bulbul, Chinese actinidia root, five cereals
Worm, tangerine leaf, dried orange peel, purslane, field pennycress, akebi, borneol, honey-fried licorice root cross 150 mesh sieves after crushing, standby；
Step 2: oyster is forged into 2.5 h in 550 DEG C in stove, forge rear vinegar and quench, fine grinding is standby into fine powder；Peach kernel is smashed to pieces, obtains peach kernel
It is broken standby；
Step 3: by the Fructus Corni after crushing, cultivated land, the Radix Astragali, Ligusticum wallichii, the root of kudzu vine, mistletoe, ginger, the tuber of pinellia, the root bark of tree peony, lopseed,
The seed of cowherb, reticulate millettia, manchurian walnut bark, scorpio, radix cyathulae, Snakegourd Fruit, the Chinese bulbul, Chinese actinidia root, maggot, tangerine leaf, dried orange peel, dent
Amaranth, field pennycress, akebi, borneol, honey-fried licorice root add water to cook 3 times, each 1-4 h, merging filtrate, and filter residue dries and uses super fine
It is random to crush, cross 400 mesh sieves；
Step 4: gained filtrate is concentrated into relative density 1.2, add that ostreae testa pulverata, peach kernel be broken, cattail pollen powder, to filter residue powder, corresponding
The borneol of parts by weight is well mixed to be produced.
A kind of 5. preparation method of external application anti-tumor Chinese medicine cream according to claim 4, it is characterised in that institute in step 3
The weight for adding water is 2-4 times of medicinal powder weight.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711147501.2A CN107823592A (en) | 2017-11-17 | 2017-11-17 | A kind of external application anti-tumor Chinese medicine cream |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711147501.2A CN107823592A (en) | 2017-11-17 | 2017-11-17 | A kind of external application anti-tumor Chinese medicine cream |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107823592A true CN107823592A (en) | 2018-03-23 |
Family
ID=61652944
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201711147501.2A Pending CN107823592A (en) | 2017-11-17 | 2017-11-17 | A kind of external application anti-tumor Chinese medicine cream |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN107823592A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116574144A (en) * | 2023-03-13 | 2023-08-11 | 河南中医药大学 | Method for preparing cornuside F from cornus officinalis leaves and application of cornuside F |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101698038A (en) * | 2009-10-23 | 2010-04-28 | 王令喜 | Paster for treating cancer pain and preparation method thereof |
| CN106177811A (en) * | 2016-08-31 | 2016-12-07 | 王清贤 | A kind of external application Chinese medicine treating pernicious ascites pleural fluid and usage thereof |
| CN106334140A (en) * | 2016-08-31 | 2017-01-18 | 赵国林 | Traditional Chinese medicine composition and preparation method thereof |
| CN106421074A (en) * | 2016-10-20 | 2017-02-22 | 心颐和国际中医药投资控股（北京）有限公司 | Traditional Chinese medicine composition with anti-cancer and anti-tumor functions and preparation method thereof |
-
2017
- 2017-11-17 CN CN201711147501.2A patent/CN107823592A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101698038A (en) * | 2009-10-23 | 2010-04-28 | 王令喜 | Paster for treating cancer pain and preparation method thereof |
| CN106177811A (en) * | 2016-08-31 | 2016-12-07 | 王清贤 | A kind of external application Chinese medicine treating pernicious ascites pleural fluid and usage thereof |
| CN106334140A (en) * | 2016-08-31 | 2017-01-18 | 赵国林 | Traditional Chinese medicine composition and preparation method thereof |
| CN106421074A (en) * | 2016-10-20 | 2017-02-22 | 心颐和国际中医药投资控股（北京）有限公司 | Traditional Chinese medicine composition with anti-cancer and anti-tumor functions and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 王兵 等: "肿瘤中医常用外治方法概述", 《中医药信息》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116574144A (en) * | 2023-03-13 | 2023-08-11 | 河南中医药大学 | Method for preparing cornuside F from cornus officinalis leaves and application of cornuside F |
| CN116574144B (en) * | 2023-03-13 | 2024-02-20 | 河南中医药大学 | Method for preparing cornuside F from cornus officinalis leaves and application of cornuside F |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN104069162A (en) | Traditional Chinese medicine for treating gouty arthritis and various bone and arthrosis pains | |
| CN104288598A (en) | Medicinal diet formula for nursing after radiotherapy and preparation method of medical diet formula | |
| CN105497784A (en) | Traditional Chinese medicine pill used for treating superficial thrombophlebitis and preparation method | |
| CN107823592A (en) | A kind of external application anti-tumor Chinese medicine cream | |
| CN105687738A (en) | Traditional Chinese medicine granules for treating intractable coughs and preparation method | |
| CN111407872A (en) | Traditional Chinese medicine composition for treating liver cancer, medicine for treating liver cancer and preparation method of medicine | |
| CN104840874A (en) | Traditional Chinese medicine pills used for aneurysm postoperative rehabilitation treatment and preparation method thereof | |
| CN104721335B (en) | A kind of Chinese medicine composition for treating follicular cyst | |
| CN103520644B (en) | Traditional Chinese medicine composition used for treating phlegm stagnation type hyperlipidaemia and preparation method of composition | |
| CN114533831B (en) | Traditional Chinese medicine composition with effects of warming middle-jiao, dispelling cold, eliminating dampness, promoting blood circulation, removing obstruction in channels and relieving pain and heat-covered bag thereof | |
| CN102335314B (en) | Chinese medicinal composition for treating stomach diseases | |
| CN102552619B (en) | Medicine for treating tumor and preparation method thereof | |
| CN107670012A (en) | A kind of internal medicine antitumor Chinese | |
| CN103908579A (en) | Spleen and stomach tonifying preparation for resisting side effects of chemotherapy and preparation method thereof | |
| CN105168907A (en) | Traditional Chinese medicine for treating hyperplasia of mammary glands | |
| CN105213885A (en) | A kind of pharmaceutical composition and application thereof for the treatment of acute pancreatitis | |
| CN104857415A (en) | Glutinous rice congee taken by patients with gastric carcinoma and producing method thereof | |
| CN103816468B (en) | A kind of capsule treating gastric cancer and preparation method thereof | |
| CN103919995A (en) | Medicine for resisting side effects of postoperative cancer patients and preparation method | |
| CN109045269A (en) | A kind of instant particles as Chinese medicine and preparation method thereof for treating postpartum anemic fainting | |
| CN104069260B (en) | Treat the drug use in osteopathy wine and preparation method of lumbar muscle strain | |
| CN109646569A (en) | A kind of Chinese medicine composition for treating diabetes (diabetes), Chinese medical extract and preparation method thereof and dosage form | |
| CN107137596A (en) | A kind of instant particles as Chinese medicine and preparation method for treating amenorrhoea headache | |
| CN107595971A (en) | A kind of capsule medicine and preparation method for treating heat gonorrhea syndrome of dampness-heat in lower jiao | |
| CN109771630A (en) | A kind of Chinese medicine composition and preparation method thereof for treating menalgia |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20180323 |
|
| RJ01 | Rejection of invention patent application after publication |