CN105687738A

CN105687738A - Traditional Chinese medicine granules for treating intractable coughs and preparation method

Info

Publication number: CN105687738A
Application number: CN201610131383.5A
Authority: CN
Inventors: 陈征远; 张雪娇
Original assignee: Individual
Current assignee: Individual
Priority date: 2016-03-09
Filing date: 2016-03-09
Publication date: 2016-06-22

Abstract

The invention discloses traditional Chinese medicine granules for treating intractable coughs and a preparation method and belongs to the field of traditional Chinese medicines. The traditional Chinese medicine granules are prepared from raw materials of effective ingredients of medicines as follows: sericea lespedeza, Dioscorea opposite, Chinese pholidota herbs, solomonseal rhizomes, perny false fairybells rhizomes, liquorice roots, paulownia flowers, Chinese dates, longspurred fairybells rhizomes, Pilose asiabell roots, malaytea scurfpea fruits, Chinese thorowax roots, Goodyera schlechtendaliana, orange fruits, walnut kernels, Veronica linariifolia, loquat seeds, nutgrass galingale rhizomes, perilla fruits, loofah sponges, pepperweed seeds, ephedra, pummelo peels and oroxylum seeds. Medicinal materials adopted by the granules conform to the monarch, minister, assistant and guide principle, and the granules suit the remedy to the case according to the pathogenesis, have effects of tonifying the kidney, absorbing qi, soothing the liver, regulating qi, strengthening the spleen, supplementing the lung, harmonizing construction and defense, nourishing yin, moistening the lung, freeing the lung, relieving asthma, reducing phlegm, relieving coughs, clearing the lung, relieving the sore throat, clearing heat and removing toxins, are good in absorbing effect, significant in curative effect and free of toxic and side effects and clinical adverse effects, and have the higher cure rate for the intractable coughs according to clinical verification.

Description

A kind of instant particles as Chinese medicine for treating intractable cough and preparation method

Art

The present invention relates to the field of Chinese medicines, particularly relate to a kind of instant particles as Chinese medicine for treating intractable cough and preparation method。

Background technology

Cough is one of modal symptom in respiratory system; it it is a kind of protective measure of human body; it is useful to body; when being subject to the stimulations such as foreign body, inflammation, secretions or anaphylaxis factor when respiratory mucosa; namely cause cough to reflexive, contribute to getting rid of from the extraneous foreign body invading respiratory tract or secretions, the elimination respiratory tract factor。But chronic cough is not healed, sleep and the quality of life of patient can be had a strong impact on, here it is medically described intractable cough。Intractable cough is clinical common disease, and patient's main clinical manifestation is itching throat, and dry cough battle array is made, and without expectorant or cough and very only have a small amount of viscous expectorant, accompanies out of breath, and prolonged difficulty is more when coughing very, recurrent exerbation, and time stops when sending out；Often make exacerbation of symptoms because of pollen, dust mite, chemical irritant, smog, activity, emotional distress, news and gas with foreign flavor, because work and the life of patient are caused very big puzzlement by it, so enjoying Pneumology Department doctor to pay attention to。

The current doctor trained in Western medicine of diagnosis of intractable cough there is no absolute standard, is often referred to without obvious physical signs of lung, the course of disease cough more than 3 weeks。Owing to this disease cause of disease is many, pathogenesis is very not clear and definite, therefore therapeutic effect is mostly unsatisfactory。Western medical treatment primary disease is generally suited the medicine to the illness and is given the Therapeutic Method such as infection eliminating phlegm and stopping cough, but curative effect is unsatisfactory。

The traditional Chinese medical science thinks intractable cough, and many because of affection of exogenous wind-cold untreated or malpractice, protracted inflammation, remaining heresy is unclear, delays tender dirty, and impairment of dispersing and descending function of the lung becomes stupid and coughs for a long time。Though it is considered herein that the sick position of intractable cough is at lung, but its pathogenesis can relate to the five internal organs, patient's chronic cough is not healed, and can cause that patient seeks and defend imbalance, disturbance of lung-QI；The spleen has the function to transport and transform nutrients, transporting mistake department, then inhibited pulmonary QI；And irritability stasis, dysfunction of SHAO YANG, superinverse is in lung, and the normal performance of function drops in a surname affecting lung, and cough frequency can be caused to make；Patient's prolonged illness cough with asthma, pneumonopathy and kidney, cause asthenia of renal qi, failure of the kidney in receiving QI, causes again water general for expectorant, and Jinsui River influences each other, then cough delay is with the passing of time。Therefore the present invention suits the remedy to the case according to the cause of disease, there is effect of improving inspiration by invigorating the kidney, depressed liver-energy dispersing and QI regulating, strengthening the spleen and tonifying the lung, harmonizing yingfen and weifen, nourishing YIN and moistening the lung, depressed lung-energy dispersing, preventing phlegm from forming and stopping coughing, removing heat from the lung and relieving sorethroat, heat-clearing and toxic substances removing, good absorbing effect, evident in efficacy, have no side effect and clinical adverse, according to clinical verification that intractable cough cure rate is higher。

Summary of the invention

The invention provides a kind of instant particles as Chinese medicine for treating intractable cough and preparation method, there is effect of improving inspiration by invigorating the kidney, depressed liver-energy dispersing and QI regulating, strengthening the spleen and tonifying the lung, harmonizing yingfen and weifen, nourishing YIN and moistening the lung, depressed lung-energy dispersing, preventing phlegm from forming and stopping coughing, removing heat from the lung and relieving sorethroat, heat-clearing and toxic substances removing, curing the disease and seek source treating both the principal and secondary aspects of a disease, the intractable cough that a variety of causes is caused is respectively provided with good curative effect。

For achieving the above object, technical scheme is implemented as follows:

A kind of instant particles as Chinese medicine for treating intractable cough, make described effective ingredient raw material composition and parts by weight be:

Herba Lespedezae Cuneatae 70～84 parts, Rhizomadioscoreae 66～81 parts, Pseudobulbus Pholidotae Chinensis 63～78 parts, Rhizoma Polygonati 60～75 parts,

Rhizoma disporopsis pernyi 56～72 parts, 53～68 parts of Radix Glycyrrhizae, Flos Paulowniae 50～64 parts, 47～60 parts of Fructus Jujubae,

Rhizoma Dispori Calcarati 44～56 parts, Radix Codonopsis 41～53 parts, Fructus Psoraleae 38～50 parts, Radix Bupleuri 35～47 parts,

Herba goodyearae repentis 32～44 parts, Fructus Aurantii 29～41 parts, semen juglandis 26～38 parts, HERBA VERONICAE DILATATAE 24～35 parts,

Radix Eriobotryae 21～32 parts, Rhizoma Cyperi 18～29 parts, Fructus Perillae 15～26 parts, Retinervus Luffae Fructus 12～22 parts,

Semen Lepidii (Semen Descurainiae) 9～18 parts, 7～15 parts of Herba Ephedrae, Exocarpium Citri Grandis 4～12 parts, Semen Oroxyli 2～9 parts。

Make described effective ingredient raw material composition and parts by weight be:

Herba Lespedezae Cuneatae 73～81 parts, Rhizomadioscoreae 69～78 parts, Pseudobulbus Pholidotae Chinensis 66～75 parts, Rhizoma Polygonati 63～72 parts,

Rhizoma disporopsis pernyi 59～69 parts, 56～65 parts of Radix Glycyrrhizae, Flos Paulowniae 53～60 parts, 50～57 parts of Fructus Jujubae,

Rhizoma Dispori Calcarati 47～53 parts, Radix Codonopsis 44～50 parts, Fructus Psoraleae 41～47 parts, Radix Bupleuri 38～44 parts,

Herba goodyearae repentis 35～41 parts, Fructus Aurantii 32～38 parts, semen juglandis 29～35 parts, HERBA VERONICAE DILATATAE 27～32 parts,

Radix Eriobotryae 24～29 parts, Rhizoma Cyperi 21～26 parts, Fructus Perillae 18～23 parts, Retinervus Luffae Fructus 15～20 parts,

Semen Lepidii (Semen Descurainiae) 12～16 parts, 9～13 parts of Herba Ephedrae, Exocarpium Citri Grandis 6～10 parts, Semen Oroxyli 3～7 parts。

Herba Lespedezae Cuneatae 77 parts, Rhizomadioscoreae 74 parts, Pseudobulbus Pholidotae Chinensis 71 parts, Rhizoma Polygonati 68 parts,

Rhizoma disporopsis pernyi 65 parts, 61 parts of Radix Glycyrrhizae, Flos Paulowniae 57 parts, 54 parts of Fructus Jujubae,

Rhizoma Dispori Calcarati 50 parts, Radix Codonopsis 47 parts, Fructus Psoraleae 44 parts, Radix Bupleuri 41 parts,

Herba goodyearae repentis 38 parts, Fructus Aurantii 35 parts, semen juglandis 32 parts, HERBA VERONICAE DILATATAE 29 parts,

Radix Eriobotryae 26 parts, Rhizoma Cyperi 23 parts, Fructus Perillae 20 parts, Retinervus Luffae Fructus 17 parts,

Semen Lepidii (Semen Descurainiae) 14 parts, 11 parts of Herba Ephedrae, Exocarpium Citri Grandis 8 parts, Semen Oroxyli 5 parts。

The preparation method of a kind of instant particles as Chinese medicine for treating intractable cough, comprises the following steps that:

(1) Herba Lespedezae Cuneatae, Rhizomadioscoreae, Pseudobulbus Pholidotae Chinensis, Rhizoma Polygonati, Flos Paulowniae, Fructus Jujubae, Rhizoma Dispori Calcarati, semen juglandis, HERBA VERONICAE DILATATAE, Radix Eriobotryae, Fructus Perillae, Exocarpium Citri Grandis, Semen Oroxyli are cleaned, dried rear mix homogeneously, put in container, add the water of 6～8 times amount in a reservoir, heated and boiled 2～3 hours, takes immersion after cooling；Remaining medicinal residues add the water of 4～6 times amount, heated and boiled 1～2 hour, after cooling, takes immersion；Merging twice gained immersion, heating, evaporation and concentration is the thick paste of relative density 1.15～1.25, standby；

(2) Rhizoma disporopsis pernyi, Herba goodyearae repentis are put in container, add the shao-hsing rice wine of 3～5 times amount, cool after boiling, continue immersion 3～5 hours, take immersion；Remaining medicinal residues add the shao-hsing rice wine of 2～4 times amount, puts after boiling and dry in the air, continue immersion 2～4 hours, take immersion；Merge twice gained immersion, add and steam the thick paste that evaporation and concentration is relative density 1.10～1.20, standby；

(3) first uniformly being dispensed in hot pot by wheat bran, cigarette of waiting rises, and adds Chinese yam slices and stirs to faint yellow as spending, and taking-up, sieve removes wheat bran, cools, dries, and pulverizing is ground into powder, crosses 100 order dusting covers, obtains fine powder, standby；

(4) take clean Radix Glycyrrhizae tabellae, add cooked Mel and a little boiled water, slightly vexed after mixing thoroughly, to put in parch container, slow fire is fried to buff, takes out, cool time tack-free, and pulverizing is ground into powder, crosses 100 order dusting covers, obtains fine powder, standby；

(5) being placed in the pot of heating by wheat bran, when playing cigarette to pot, add Radix Codonopsis sheet, stir to buff, take out sieve and remove wheat bran, cool, pulverizing is ground into powder, crosses 100 order dusting covers, obtains fine powder, standby；

(6) taking clean Fructus Psoraleae saline to mix thoroughly, micro-profit, put to fry with slow fire in pot and heave to micro-, take out, dry, pulverizing is ground into powder, crosses 100 order dusting covers, obtains fine powder, standby；

(7) taking radix bupleuri tablet, mix thoroughly with vinegar, put in pot and exhaust and micro-dry to vinegar with slow fire stir-fry, take out, dry, pulverizing is ground into powder, crosses 100 order dusting covers, obtains fine powder, standby；

(8) Fructus Aurantii is put in pot with saline moistening to water to the greatest extent after, slow fire fried dry, take out, dry, pulverizing is ground into powder, crosses 100 order dusting covers, obtains fine powder, standby；

(9) taking Rhizoma Cyperi and clean section, add quantitative rice vinegar and mix thoroughly, after moistening is sucked to vinegar, put in parch container, heat fried dry with slow fire, taking-up is dried in the air cool, and sieve removes chip, and pulverizing is ground into powder, crosses 100 order dusting covers, obtains fine powder, standby；

(10) taking the Retinervus Luffae Fructus being cut into segment, stir to yellow degree of being with wheat bran, take out, sieve removes wheat bran, cools, and pulverizing is ground into powder, crosses 100 order dusting covers, obtains fine powder, standby；

(11) taking clean Semen Lepidii (Semen Descurainiae) and put in pot, fry with slow fire and heave to micro-, and have fragrance degree of being, take out, cool, pulverizing is ground into powder, crosses 100 order dusting covers, obtains fine powder, standby；

(12) taking refined honey and add certain amount of boiling water dilution, drench in Herba Ephedrae section and mix moistening thoroughly, put in parch container, heat with slow fire, fry and dry in the air cool to taking-up time tack-free, pulverizing is ground into powder, crosses 100 order dusting covers, obtains fine powder, standby；

(13) by the thick paste of step (1), step (2) gained, mix with the fine powder of gained in step (3), step (4), step (5), step (6), step (7), step (8), step (9), step (10), step (11), step (12), add adjuvant sucrose and dextrin mix homogeneously makes granule, after dry, granulate, it is packaged into the instant particles as Chinese medicine of every bag of 10g。

The property of medicine of Chinese medicine used by the present invention is as follows:

Herba Lespedezae Cuneatae: bitter in the mouth, puckery, cool in nature。Return lung；Liver；Kidney channel。The kidney invigorating arresting seminal emission；Invigorating spleen to remove dampness；Preventing phlegm from forming and stopping coughing；Heat-clearing and toxic substances removing。Cure mainly and suffer from a deficiency of the kidney；Seminal emission；The enuresis；Frequent micturition；Nebulousurine；Leukorrhagia；Have loose bowels；Dysentery；Edema；Infantile malnutrition；Cough and asthma；Traumatic injury；Conjunctival congestion and swelling pain；Ulcerative carbuncle toxic swelling；Insect-bite。" Traditional Chinese Medicine in Sichuan will ": controlling the weak enuresis, man's nebulousurine, woman leucorrhea, deficiency of YIN gas is weak, promoting lactation, treats infantile malnutrition。Modern study proves: the effects such as Herba Lespedezae Cuneatae has cough-relieving, eliminates the phlegm, relievings asthma, antibacterial, to the selective excitation in uterus。

Rhizomadioscoreae: sweet in the mouth；Property is put down。Enter spleen；Lung；Kidney channel。Spleen reinforcing nourishing the stomach；Promote the production of body fluid lung benefiting；The kidney invigorating arresting seminal emission。Cure mainly insufficiency of the spleen lack of appetite；Incessant chronic diarrhea；The deficiency of the lung is breathed with cough；Emission due to deficiency of the kidney；Leukorrhagia；Frequent micturition；Deficiency-heat is quenched one's thirst。Compendium of Material Medica is carried: " strengthening the spleen and tonifying the lung, long will is calmed the nerves, and controls lassitude, inappetence, dry, the kidney qi loss of insufficiency of lung-QI etc.。" modern medicine study shows, Rhizomadioscoreae plants trace element and other mineral rich in 18 seed amino acids and more than 10, it is possible to prevent Human Lipid Metabolism exception and arteriosclerosis; to safeguarding that insulin normal function also has certain effect, can strengthen body immunity, benefit heart and tranquilizing mind; rather cough Dingchuan, slow down aging。

Pseudobulbus Pholidotae Chinensis: sweet in the mouth；Micro-hardship；Cool in nature。Return lung；Kidney channel。Nourishing YIN and moistening the lung；Heat-clearing and toxic substances removing；Dampness removing；Repercussive。Cure mainly cough due to lung-heat；Hemoptysis；Spit blood；Dizziness；Headache；Nocturnal emission；Laryngopharynx swelling and pain；Rheumatalgia；Damp and hot edema；Dysentery；Leucorrhea；Infantile malnutrition；Scrofula；Traumatic injury。" Guangdong Chinese medicine " II: lung heat clearing is hot and suffocating, supports lung yin, preventing phlegm from forming and stopping coughing。Controlling endogenous cough, children's's heat is amassed。

Rhizoma Polygonati: sweet in the mouth；Property is put down。Enter spleen；Lung；Kidney channel。Nourishing YIN and moistening the lung；Invigorating the spleen and replenishing QI；Zishen fill fine。Cure mainly deficiency of YIN chronic cough；Xeropulmonary cough；Insufficiency of the spleen weak；Lack of appetite xerostomia；Quench one's thirst；Deficiency of the kidney soreness of the waist and knees；Impotence and seminal emission；Tinnitus order is dark；Early whitening of beard and hair；Body weakness with emaciation is thin；Wind favus disease。" book on Chinese herbal medicine meets former " carries: " alleviating distention in middle-JIAO QI invigorating, makes five Tibetan be in harmonious proportion, and muscle sufficiency, bone marrow is hard by force, is all the merit of nourishing YIN。" modern medicine study confirmation; the blood glucose that epinephrine is caused by Rhizoma Polygonati raises significant inhibitory action; common causative fungus is had inhibitory action in various degree; raise Liver Superoxide Dismutase Activity activity; reduces myocardium lipofuscin content and reduces; strengthens the tolerance to anoxia, in addition with antiviral efficacy。

Rhizoma disporopsis pernyi: sweet in the mouth；Property is put down。Replenishing QI to invigorate the spleen；Nourishing YIN and moistening the lung；Relaxing muscles and tendons to promote blood circulation。Cure mainly puerperal asthenia；Infantile malnutrition；Cough due to yin deficiency；Hyperhidrosis；Xerostomia；Treating swelling and pain by traumatic injury；Rheumatalgia；Lumbago。" Guizhou medical herbs ": nourishing YIN and moistening the lung, promoting the production of body fluid to quench thirst。

Radix Glycyrrhizae: sweet in the mouth；Property is put down。GUIXIN；Lung；Spleen；Stomach warp。Invigorating the spleen and replenishing QI；Heat-clearing and toxic substances removing；Expelling phlegm for arresting cough；Relieving spasm to stop pain；Coordinating the actions of various ingredients in a prescription。Cure mainly weakness of the spleen and stomach；Fatigue and weakness；Shortness of breath and palpitation；Cough with copious phlegm；Gastral cavity abdomen four muscle spasm of the leg and foot pain；Carbuncle sore tumefacting virus；Cushion toxicity。Compendium of Material Medica is carried: " in all medicines, Radix Glycyrrhizae is monarch。Controlling 72 kinds of mammary calculus poison, draft is malicious by every means to solve 1,002, is in harmonious proportion and gains merit from medicine。" modern medicine study confirmation; Radix Glycyrrhizae has stronger Detoxication; also have antiulcer, anti-inflammatory, spasmolytic antitussive, blood pressure lowering, blood fat reducing, antitumaous effect; is widely used in the diseases such as treatment pharyngolaryngitis, laryngitis, tracheitis, bronchitis, asthma, cough, hemoptysis, additionally has anti-gastric-ulcer, gastritis effect。

Flos Paulowniae: bitter in the mouth；Cold in nature。Removing heat from the lung and relieving sorethroat；Removing toxic substances and promoting subsidence of swelling。Cure mainly cough due to lung-heat；Acute tonsillitis；Bacillary dysentery；Acute bowel fire；Acute conjunctiva fire；Parotid gland fire；Furuncle and phyma；Skin ulcer tinea。Modern medicine study proves: Flos Paulowniae has antibacterial, antiviral, antitussive, eliminates the phlegm, relievings asthma, stabilizes, lowers the temperature, blood pressure lowering, antiinflammatory and anticancer effect。

Fructus Jujubae: sweet in the mouth；Temperature。Return spleen；Stomach warp。Tonifying the spleen and stomach；Replenishing QI and blood；Tranquilizing mind；Battalion is adjusted to defend；And the property of medicine。Cure mainly weakness of the spleen and stomach；Insufficiency of vital energy and blood；Anorexia and loose stool；Fatigue and weakness；Palpitation and insomnia；Woman hysteria；Disharmony of nutrient QI with defensive QI。" herbal classic ": main trusted subordinate's pathogen, regulating the spleen and stomach supports spleen, helps 12 warps。Flat gastric qi, logical nine orifices, mend few gas, few body fluid, not enough in body, frightened, heaviness of limbs, and hundred medicines。

Rhizoma Dispori Calcarati: sweet in the mouth；Property is put down。Nourishing YIN and moistening the lung, promoting the production of body fluid and benefiting QI。Control cough due to lung-heat, steaming bone and consumptive fever, soreness of the waist and knees, night sweat, turbid damp leucorrhea。

Radix Codonopsis: sweet in the mouth；Property is put down。Return spleen；Lung meridian。Strengthening the spleen and tonifying the lung；Supplementing QI for promoting the production of body fluid。Cure mainly weakness of the spleen and stomach；Anorexia and loose stool；Limbs fatigue；The deficiency of the lung is breathed with cough；Breathe hard spontaneous perspiration；The all cards of deficiency of both QI and blood。" moral joins book on Chinese herbal medicine " carries: " lung heat clearing gold, invigorating primordial QI, open sound, help biceps。" modern medicine study confirms; Radix Codonopsis energy Gastrointestinal motility adjustment, antiulcer, enhancing immunologic function; on excited and suppress two kinds of nervous process to have impact, erythrocyte, hemoglobin, reticulocyte can be raised, also have the effect of slow down aging and antioxidation, radioprotective, blood pressure lowering。

Fructus Psoraleae: acrid in the mouth；Bitter；Warm in nature。Return kidney；Pericardium；Spleen；Stomach；Lung meridian。Reinforcing the kidney and supporting YANG；Helping inspiration to relieve asthma；Warming spleen and stopping diarrha。Cure mainly: insufficiency of kidney-YANG；Below element deficiency and cold；Chills and pain of the waist and kness；Sexual impotence essence；Frequent micturition；The enuresis；Failure of the kidney in receiving QI；Dyspnea due to deficiency is more than；Asthenia of both the spleen and kidney；Stool chronic diarrhea；Vitiligo；Alopecia areata；Psoriasis。" beautiful Chinese catalpa medicine solution ": warm water and soil, digests diet, rises and reaches taste, convergence lingering diarrhea, seminal emission, leukorrhagia, drown many, just slide all cards。" medical center bun want ": control deficiency and coldness and breathe heavily and cough。Modern medicine study proves: Fructus Psoraleae energy coronary artery dilator, excited heart, improves Heart Pumping Power；Uterus can be shunk and shorten the bleeding time, reducing amount of bleeding；There is estrogen-like effects, vagina keratinization can be strengthened, increase uterus weight；Cause photosensitization, take orally or be coated with outward skin, through daylight or ultraviolet radiation, localised skin pigmentation can be made；Immunity and endocrine function, nervous system regulation function can be strengthened, promote bone marrow hematogenesis；Can diastole bronchial smooth muscle；In addition still there are hemostasis, antitumor, slow down aging, antibacterial and insecticidal action。

Radix Bupleuri: bitter in the mouth；Pungent；Cold nature。Return liver；Gallbladder meridian。Induce sweat and bring down a fever；Dispersing the stagnated live-QI to relieve the stagnation of QI, rises and lifts yang-energy。Cure mainly: fever caused by exogenous pathogens；Alternate attack of chill and fever；Malaria；Hypochondriac pain due to stagnation of liverQI mammary swelling；Headache dizziness；Menoxenia；The proctoptosis of collapse of QI；Uterine prolapse；Gastroptosis。" detailed outline ": " controlling yang-energy to sink, suppressing the hyperactive liver, gallbladder, three burnt, envelope is mutually fiery, and headache, dizziness, and blurred vision, swelling pain are hidden from view, deaf ring, all malarias, and lump at the left hypochondrium cold and heat, married woman's invasion of the blood-chamber by heat, irregular menstruation, children's's varioliform exanthema waste heat, the thin heat of five kinds of child malnutrition。" modern medicine study confirms, Radix Bupleuri has antipyretic, calm, analgesia, antitussive, antiinflammatory action。Resist hepatic injury, function of gallbladder promoting, anti-fatty liver simultaneously, and promote that enterokinesia etc. has certain effect。

Herba goodyearae repentis: sweet in the mouth；Pungent；Property is put down。Nourishing the lung to arrest cough；Tonify Qi of the kidney；Promoting flow of QI and blood；Subduing swelling and detoxicating。Cure mainly pulmonary tuberculosis cough；Tracheitis；Dizzy weak；Neurasthenia；Sexual impotence；Traumatic injury；Arthralgia；Laryngopharynx swelling and pain；Acute mastitis；Furuncle；Scrofula；Venom。" Zhejiang conventional medical herbs among the people ": " heat-clearing and toxic substances removing, antiinflammatory detumescent。Controlling venom, carbuncle furuncle, pneumonopathy is coughed, tracheitis。"

Fructus Aurantii: bitter in the mouth；Acid；Cold nature。Enter lung；Spleen；Liver；Stomach；Large intestine channel。Regulate the flow of vital energy the chest stuffiness relieving；The stagnant removing food stagnancy of row。Cure mainly septum pectorale feeling of fullness；Distending pain over the hypochondrium；Accumulation of food in the stomach and intes tine due to indigestion；Distension and fullness in the abdomen；Weight after dysentery；Proctoptosis；Uterine prolapse。" detailed outline " carries: " controlling thoracic obstruction feeling of fullness, with Fructus Aurantii Immaturus for key medicine, all sides control the inferior internal hemorrhoid with bleeding dysentery, the secret plug of large intestine, tenesmus, and again with Fructus Aurantii for general, then Fructus Aurantii Immaturus is not only controled the inferior, and Fructus Aurantii not only controls height also。" clinic study shows, Fructus Aurantii has the effect of significant resisting pathogenic microbes, it is suppressed that allergy, in addition with the effect such as calmness, diuresis, excited uterus, heart tonifying, boosting, function of gallbladder promoting。

Semen juglandis: sweet in the mouth；Puckery；Warm in nature。Return kidney；Liver；Lung meridian。Tonifying the kidney to consolidate the essence；Warming the lung Dingchuan；Loosening bowel to relieve constipation。Cure mainly: lumbago flaccidity of the lower limbs；Frequent micturition；The enuresis；Sexual impotence；Seminal emission；Chronic cough dyspnea with rapid and short breath；Dryness of the intestine constipation；Stranguria caused by urinary stone and skin infection scrofula。" Records of Tradition Chinese and Western Medicine in Combination ": Semen Juglandis, for the key medicine of nourishing the liver and kidney, strong muscles and bones, therefore kind control pain in the lumbar region and has a pain in the leg, all bones and muscles pain。For its can the kidney invigorating, therefore can teeth consolidating tooth, crow beard and hair, control asthenia and breathe heavily and cough, gas does not return unit, part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels deficiency and coldness, frequent micturition, all cards of woman's metrorrhagia and leukorrhagia。Its property heavily fortified point that can disappear again opens the stasis of blood, controls trusted subordinate's pain, and sand Stranguria, stranguria caused by urinary stone are made to ache, and kidney loses water of can not filtering, dysuria。Modern medicine proves: the phospholipid in semen juglandis, and cranial nerve has fine health-care effect。Walnut oil contains unsaturated fatty acid, has the effect preventing and treating arteriosclerosis。Containing indispensable trace element of human body such as zinc, manganese, chromium in semen juglandis, human body zinc, Fe content in aging course day by day reduce, and chromium has promotion glucose utilization, cholesterol metabolism and the cardiovascular function of protection。The antitussive and antiasthmatic effect of semen juglandis is also fairly obvious, winter, to chronic tracheitis and asthmatics's excellent curative。

HERBA VERONICAE DILATATAE: bitter in the mouth；Cold in nature。Heat-clearing and toxic substances removing；Preventing phlegm from forming and stopping coughing。Cure mainly cough due to lung-heat；Lung abscess；Cough vomiting bloody pus；Furuncle toxic swelling；Skin eczema；Rubella pruritus。

Radix Eriobotryae: bitter in the mouth；Property is put down；Nontoxic。Return kidney channel。Preventing phlegm from forming and stopping coughing；Soothing the liver circulation of qi promoting；Inducing diuresis to remove edema。Cure mainly cough with copious phlegm；Hernia；Edema；Scrofula。" book on Chinese herbal medicine is new again ": control hernia, consumer edema, profit joint, control scrofula。

Rhizoma Cyperi: acrid in the mouth；It is slightly cold；Nontoxic。Return liver；Lung；Spleen；Stomach；Tri-jiao channel。Regulate the flow of vital energy resolving depression；Menstruction regulating and pain relieving；Antiabortive。Cure mainly distending pain over the hypochondrium；Mammary swelling is educated；Hernia pain；Menoxenia；Gastral cavity abdomen feeling of fullness pain；Belch acid regurgitation, vomiting and nausea；Abdominal pain during menstruation；Bleeding not during menses；Frequent fetal movement。" detailed outline " dissipates the cold epidemic disease of seasonal epidemic pathogens, and profit three is burnt, Xie Nvyu, and the diet that disappears gathers, phlegm retention feeling of fullness, edema of dorsum of the foot, abdominal distention, beriberi, only trusted subordinate, limbs, head, order, tooth, all pains of ear, and ulcer sores is spitted blood, hematochezia, hematuria, married woman's bleeding not during menses, menoxenia, all kinds of diseases and ailments in puerperal before tire。

Fructus Perillae: acrid in the mouth；Warm in nature。Return lung；Large intestine channel。Sending down the abnormal ascending QI；Expectorant；Relieving asthma；Intestine moistening。Cure mainly expectorant and stop up QI rising in reverse order；Cough and asthma；Dryness of the intestine constipation。" medicineization justice " load: " Fructus Perillae patent stagnated phlegm。Cough with dyspnea is gas lift then, and dyspnea with rapid respiration is pulmonary distension then, with this therapeutic method to keep the adverse QI flowing downwards Dingchuan。Heat insulation then expectorant is stopped up, and expectorant knot then vexed pain, with this eliminating phlegm eliminating stagnation。" modern medicine study confirms, Fructus Perillae has reduction blood fat, blood pressure, it is suppressed that platelet aggregation, antioxidation, anticancer, and significant bacteriostasis。

Retinervus Luffae Fructus: bitter in the mouth；Cool in nature。Return lung；Liver；Stomach warp。Dredge the meridian passage, heat-clearing and toxic substances removing, inducing diuresis to remove edema, hemostasis。Cure mainly distending pain in the chest and hypochondrium, rheumatic arthralgia, muscle arteries and veins contracture, woman's amenorrhea, galactostasis, phlegm-heat cough, pyretic toxicity carbuncle, anal fistula, edema, dysuria, have blood in stool, metrorrhagia。" book on Chinese herbal medicine is just read ": Retinervus Luffae Fructus, enters meridians, solves pathogenic heat。Evanescence of heat then wind goes, and in network, body fluid will not be tied combined into expectorant, becomes all diseases of toxic swelling, the ear therefore cloud detoxifies。Modern medicine study proves: hepar damnification is had therapeutical effect by Retinervus Luffae Fructus, and has heart tonifying diuresis and antineoplastic effect。

Semen Lepidii (Semen Descurainiae): acrid in the mouth；Bitter；Cold in nature。Enter lung；The heart；Liver；Stomach；Bladder warp。Eliminating the pathogens from the lung sending down the abnormal ascending QI；Eliminating phlegm and relieving asthma；Inducing diuresis to remove edema；Let out by heresy。Cure mainly sputum and stop up the dyspnea and cough with excessive sputum of lung；Lung abscess；Edema；Chest and abdomen hydrops；Dysuria；Chronic pulmonary heart disease；Breathing heavily of heart failure is swollen；Scrofula tuberculosis。" not Lu " load: " lower bladder water, volt stays steam, between skin evil waterborne go out, the edema of the face, the sudden and violent apoplexy miliaria alba of body is itched, profit lower abdomen。" modern medicine study confirmation, Semen Lepidii (Semen Descurainiae) has significant cardiotonic, adds heart tonifying and shrinks, decreased heart rate, retardance heart conduction, reduces venous pressure, in addition with diuresis。

Herba Ephedrae: acrid in the mouth；Micro-hardship；Warm in nature。Return lung；Bladder warp。Relieving the exterior syndrome by diaphoresis；Depressed lung-energy dispersing；Inducing diuresis to remove edema。Cure mainly chill exterior syndrome；Fever with aversion to cold；Lossless；Headache body pain；Heresy is stopped up in lung；Inhibited pulmonary QI；Cough and asthma；Edema caused by wind；Dysuria；Rheumatic arthralgia；Numbness of the skin and rubella pruritus；Carbuncle of yin nature sucutaneous nodule。" herbal classic " carries: " main apoplexy, cold headache, pyrexial malaria。Delivering perspiration, uncharm steam, only cough with dyspnea, and except cold and heat, broken heavily fortified point gathers。" modern medicine study shows; the ephedrine contained by Herba Ephedrae can play the adrenergic effect of class indirectly; strengthens myocardial contraction; coronary artery dilating, brain, muscle vascular; shrinks the internal organs such as kidney, spleen and skin, mucosa blood vessel; raising blood pressure, loose bronchus and gastrointestinal smooth muscle, increase trigone of bladder flesh and sphincteral tension force, the skeletal muscle tensity that can make fatigue significantly and enduringly raises, in addition with sweating and heat resolving, antibacterial, antiviral, antiallergic, immunity, antitussive, relieving asthma, eliminate the phlegm, diuresis。

Exocarpium Citri Grandis: bitter in the mouth；Pungent；Warm in nature。Enter spleen；Lung meridian。Drying dampness to eliminate phlegm；Regulate the flow of vital energy；Help digestion。Cure mainly cough due to wind and cold's abundant expectoration；Vomiting singultus；Accumulation of food in the stomach and intes tine due to indigestion；Abdominal distention。" Bencao Congxin " carries: " Huazhou Pericarpium Citri Reticulatae, expectorant ZHILING, so disappearing, it is too high to cut down, and should not gently use "。Classical ancient prescription has ERCHEN TANG, " drying dampness to eliminate phlegm, regulate the flow of vital energy and in, control cough due to damp-phlegm。", Daotan Tang, " removing dampness and eliminating phlegm, activating QI to alleviate the depression, cure mainly accumulation and obstruction of sputum, chest and diaphragm painful abdominal mass plug, or cough feel sick, diet is thought less, and liver-wind holds expectorant under the arm, vomiting and unable to take food, even syncope due to accumulation of phlegm person。" modern medicine study confirmation, Exocarpium Citri Grandis has significant antiinflammatory, reduces platelet aggregation, speeds the effects such as blood flow, is effectively improved the permeability of blood capillary。"

Semen Oroxyli: mildly bitter flavor；Sweet；Cold nature。Sore-throat relieving lung moistening；Dispersing the stagnated liver-QI for regulating the stomach；Expelling pus and promoting granulation。Cure mainly pharyngalgia sore throat；Hoarseness；Cough；Stomachache due to hyperactive liver-QI attacking the stomach；Skin infection is burst for a long time and is not held back；Acute eczema。" the southern regions of the Yunnan Province book on Chinese herbal medicine " load: " broken legendary venomous insect amasss, except the poison of tympanitis due to blood stasis, gas legendary venomous insect for Dingchuan, expectorant。Again can qi-restoratives, alleviating distention in middle-JIAO, feed。" modern medicine study proves, Semen Oroxyli seed, seed coat, containing baicaligenin, have antiinflammatory, antiallergic action, diuresis, function of gallbladder promoting, the effect of cholesterol reducing, and human body nasopharyngeal carcinoma cell is had cytotoxic activity by the chrysin contained in addition。

The present invention compared with prior art, has the advantages that

The present invention selects medical material monarch, minister, a left side, makes all reasons all standby, the property of medicine is suitable mutually auxiliary mutually, suit the remedy to the case for the cause of disease causing intractable cough, there is effect of improving inspiration by invigorating the kidney, depressed liver-energy dispersing and QI regulating, strengthening the spleen and tonifying the lung, harmonizing yingfen and weifen, nourishing YIN and moistening the lung, depressed lung-energy dispersing, preventing phlegm from forming and stopping coughing, removing heat from the lung and relieving sorethroat, heat-clearing and toxic substances removing, good absorbing effect, evident in efficacy, have no side effect and clinical adverse, according to clinical verification that intractable cough cure rate is higher。

Detailed description of the invention

Below in conjunction with specific embodiment, the present invention is further elaborated。

Embodiment 1

The raw material of effective ingredient of the present invention forms and weight is:

Herba Lespedezae Cuneatae 70～84g, Rhizomadioscoreae 66～81g, Pseudobulbus Pholidotae Chinensis 63～78g, Rhizoma Polygonati 60～75g,

Rhizoma disporopsis pernyi 56～72g, Radix Glycyrrhizae 53～68g, Flos Paulowniae 50～64g, Fructus Jujubae 47～60g,

Rhizoma Dispori Calcarati 44～56g, Radix Codonopsis 41～53g, Fructus Psoraleae 38～50g, Radix Bupleuri 35～47g,

Herba goodyearae repentis 32～44g, Fructus Aurantii 29～41g, semen juglandis 26～38g, HERBA VERONICAE DILATATAE 24～35g,

Radix Eriobotryae 21～32g, Rhizoma Cyperi 18～29g, Fructus Perillae 15～26g, Retinervus Luffae Fructus 12～22g,

Semen Lepidii (Semen Descurainiae) 9～18g, Herba Ephedrae 7～15g, Exocarpium Citri Grandis 4～12g, Semen Oroxyli 2～9g。

The processing step of process for preparing medicine of the present invention is:

Usage and dosage: oral, each 1 bag of every day 3 times, 1 hour ante cibum took after mixing it with water with boiled water, 7 days was 1 course for the treatment of, and Chinese medicine of the present invention is not taken by pregnant women。

Embodiment 2

Herba Lespedezae Cuneatae 73～81g, Rhizomadioscoreae 69～78g, Pseudobulbus Pholidotae Chinensis 66～75g, Rhizoma Polygonati 63～72g,

Rhizoma disporopsis pernyi 59～69g, Radix Glycyrrhizae 56～65g, Flos Paulowniae 53～60g, Fructus Jujubae 50～57g,

Rhizoma Dispori Calcarati 47～53g, Radix Codonopsis 44～50g, Fructus Psoraleae 41～47g, Radix Bupleuri 38～44g,

Herba goodyearae repentis 35～41g, Fructus Aurantii 32～38g, semen juglandis 29～35g, HERBA VERONICAE DILATATAE 27～32g,

Radix Eriobotryae 24～29g, Rhizoma Cyperi 21～26g, Fructus Perillae 18～23g, Retinervus Luffae Fructus 15～20g,

Semen Lepidii (Semen Descurainiae) 12～16g, Herba Ephedrae 9～13g, Exocarpium Citri Grandis 6～10g, Semen Oroxyli 3～7g。

The process for preparing medicine processing step of the present embodiment and usage and dosage and embodiment 1 are identical。

Embodiment 3

Herba Lespedezae Cuneatae 77g, Rhizomadioscoreae 74g, Pseudobulbus Pholidotae Chinensis 71g, Rhizoma Polygonati 68g,

Rhizoma disporopsis pernyi 65g, Radix Glycyrrhizae 61g, Flos Paulowniae 57g, Fructus Jujubae 54g,

Rhizoma Dispori Calcarati 50g, Radix Codonopsis 47g, Fructus Psoraleae 44g, Radix Bupleuri 41g,

Herba goodyearae repentis 38g, Fructus Aurantii 35g, semen juglandis 32g, HERBA VERONICAE DILATATAE 29g,

Radix Eriobotryae 26g, Rhizoma Cyperi 23g, Fructus Perillae 20g, Retinervus Luffae Fructus 17g,

Semen Lepidii (Semen Descurainiae) 14g, Herba Ephedrae 11g, Exocarpium Citri Grandis 8g, Semen Oroxyli 5g。

Clinical data:

1, case selection

Selecting the intractable cough patient 60 example clinical observation that my institute makes a definite diagnosis, patient is randomly divided into two groups。Treatment group 30 example, wherein male 17 example, women 13 example, 6～65 years old age, 44.6 years old mean age, the shortest person of the course of disease 1 month, most elder 4 months, average 1.4 months。Matched group 30 example, wherein male 16 example, women 14 example, 7～67 years old age, 45.3 years old mean age, the shortest person of the course of disease 1 month, most elder 4 months, average 1.3 months。Two groups of qualifications and record of service are basically identical, without significant difference, have comparability。

2, treatment group patient takes medicine of the present invention, and oral, each 1 bag of every day 3 times, 1 hour ante cibum took after mixing it with water with boiled water, within 7 days, was 1 course for the treatment of, took 1～3 course for the treatment of。The matched group symptom according to the intractable cough being diagnosed to be, gives antibiotic to the ill and relieving cough and reducing sputum medicine is treated。

3, efficacy determination:

(1) curing: cough transference cure, other symptoms all disappear, without recurrence after drug withdrawal 1 week。

(2) take a turn for the better: cough symptom substantially alleviates, and other symptoms take a turn for the better。

(3) invalid: symptom is with treating front no significant difference。

4, result

Treatment group cure rate 80%, total effective rate 96.7%, matched group cure rate 53.3%, total effective rate 83.3%, two groups of comparitive study, difference has a statistical significance (P < 0.05), therefore treatment group is substantially better than matched group for the curative effect of primary disease。

1 liang of table group patient clinical comparitive study

Model case is illustrated:

1, Zhao's ××, man, 46 years old。This patient occurs dry cough symptom often when replacing the autumn and winter, evening exacerbation of symptoms, daytime, cough alleviated, outbreak continues more than 1 month every time, take antiinflammatory and antitussive to no effect, institute's inquiring later, diagnosis is intractable cough on inspection, after taking 1 course for the treatment of of Chinese medicine of the present invention, readme cough symptom substantially alleviates, and follows the doctor's advice after continuing to take 1 course for the treatment of of Chinese medicine of the present invention, and cough symptom is wholly absent, without recurrence after drug withdrawal 1 week, fully recover。

2, grandson's ××, female, 28 years old。Patient winter postinfectious cough always bad, continue 1 wheat harvesting period, oneself take cough suppressing medicine effect bad, institute's inquiring later, diagnosis is for intractable cough on inspection, after taking 2 courses for the treatment of of Chinese medicine of the present invention, cough symptom is wholly absent, and without recurrence after drug withdrawal 1 week, fully recovers。

Intractable cough is one cough type relatively common clinically, patient have upper respiratory tract infection history more after through treating other transference cures and protracted course of disease of coughing, its pathogenesis doctor trained in Western medicine thinks that cough occurs in the allergic airway disease inflammation owing to stimulating air flue to cause after viral infection, and it is unsatisfactory that doctor trained in Western medicine focuses on use antibiotic therapy effect。Chinese medicine of the present invention is suited the remedy to the case according to the cause of disease, cures the disease and seeks source treating both the principal and secondary aspects of a disease, side in Radix Codonopsis, Rhizomadioscoreae can strengthening the spleen and tonifying the lung, supplementing QI for promoting the production of body fluid；Radix Bupleuri in side, Rhizoma Cyperi, Fructus Aurantii can depressed liver-energy dispersing and QI regulating, induce sweat and bring down a fever；Herba goodyearae repentis, Fructus Psoraleae in side, semen juglandis can improving inspiration by invigorating the kidney, warming the lung Dingchuan；In side, Fructus Jujubae can harmonizing yingfen and weifen；Rhizoma Polygonati, Rhizoma Dispori Calcarati, Pseudobulbus Pholidotae Chinensis in side, Rhizoma disporopsis pernyi can nourishing YIN and moistening the lung；Herba Lespedezae Cuneatae, Radix Eriobotryae, Retinervus Luffae Fructus, HERBA VERONICAE DILATATAE in side, Exocarpium Citri Grandis can heat-clearing and toxic substances removing, preventing phlegm from forming and stopping coughing；Flos Paulowniae in side, Semen Oroxyli can removing heat from the lung and relieving sorethroat；Side's epheday intermedia can depressed lung-energy dispersing；Semen Lepidii (Semen Descurainiae) in side, Fructus Perillae can eliminating the pathogens from the lung sending down the abnormal ascending QI, eliminating phlegm and relieving asthma；In side, Radix Glycyrrhizae can expelling phlegm for arresting cough, coordinating the actions of various ingredients in a prescription；In side, all medicines share, effect of improving inspiration by invigorating the kidney, depressed liver-energy dispersing and QI regulating, strengthening the spleen and tonifying the lung, harmonizing yingfen and weifen, nourishing YIN and moistening the lung, depressed lung-energy dispersing, preventing phlegm from forming and stopping coughing, removing heat from the lung and relieving sorethroat, heat-clearing and toxic substances removing can be played altogether, make lung recover Xuan Fasu to drop, and cough from only according to clinical verification that intractable cough cure rate is higher。

Claims

1. one kind for treating the instant particles as Chinese medicine of intractable cough, it is characterised in that: raw material composition and the parts by weight of making described effective ingredient are:

2. a kind of instant particles as Chinese medicine for treating intractable cough according to claim 1, it is characterised in that: make described effective ingredient raw material composition and parts by weight be:

3. a kind of instant particles as Chinese medicine for treating intractable cough according to claim 1, it is characterised in that: make described effective ingredient raw material composition and parts by weight be:

4. the preparation method of a kind of instant particles as Chinese medicine for treating intractable cough according to claims 1 to 3, it is characterised in that: comprise the following steps that: