CN103041011B - Oral drug for treating gosling candidiasis - Google Patents

Abstract

The invention provides an oral medicine for treating goose candidiasis and a preparation method thereof. Its weight components are: 15-25 parts of white fresh skin, 12-18 parts of Patrinia, 12-18 parts of Cortex Phellodendri, 12-18 parts of Sophora flavescens, 8-12 parts of Qingdai, 6-8 parts of nystatin, 2-4 parts of borneol, 50-70 parts of mature vinegar. The organic combination, dialectical compatibility and mutual assistance of the above-mentioned medicines enhance the efficacy of the prescription for clearing away heat and dampness, detoxifying and dispelling blood stasis, so as to achieve the purpose of curing oral lesions of goose candidiasis albicans. In particular, the medicine is directly injected into the oral lesions of the suffering goose, so as to directly exert the drug effect. The oral medicine for goose candidiasis prepared by the preparation method of the oral medicine for treating goose candidiasis has the advantages of low cost, easy preparation, no toxic and side effects, and remarkable curative effect. Clinical practice has proved that the drug has a cure rate of 96.68% and an effective rate of 100%.

Description

Oral medicine for treating goose candidiasis

technical field

The invention relates to an oral medicine for treating goose candidiasis and a preparation method thereof. the

Background technique

Gosling candidiasis albicans, also known as thrush, is a fungal infectious disease of the upper gastrointestinal tract of poultry caused by Candida albicans, characterized by the formation of milky white patches (pseudomembranes) on the upper gastrointestinal mucosa of the mouth, throat, etc. Causes inflammation of the mucous membranes, causing ulcers or scaly lesions. The bacterium widely exists in nature and in the digestive tract and respiratory tract of healthy poultry. When various reasons reduce the body's resistance, such as poor environmental conditions, vitamin deficiency and long-term use of antibiotics, the balance of the digestive tract flora is imbalanced and the disease is induced. Poultry are susceptible to this disease, and geese are highly susceptible to goslings within 6 weeks of age. The disease is mainly transmitted through the digestive tract, and contaminated feed, drinking water, bedding, etc. are all transmission media; it can also be transmitted through eggshells. The disease spreads rapidly, and the morbidity and mortality are high, which brings great economic losses to farmers. the

Clinical symptoms and pathological changes

It mostly occurs in goslings less than 6 weeks old. The affected geese are depressed, with loose feathers, slow growth, standing still, loss of appetite or loss of appetite, dilated, drooping, soft, and oppressive pain (screaming and struggling). When the sick goose is lifted upside down, a large amount of rancid smelling liquid often flows out of the mouth and nose. Milky white or yellow spots appear on the oral mucosa and tongue, and then merge into a white film. There are typical thrush like cheese, and the red bleeding ulcer surface can be seen after peeling off forcefully. The sick gosling finally becomes emaciated and dies. Pathological autopsy shows that, except for oral lesions, caseous necrotic pseudomembrane is more common in crops, and the mucosa thickens, forming white bean-sized nodules and ulcers, which are covered with a layer of white pseudomembrane. The above-mentioned lesions can also be seen in the esophagus and glandular stomach. Scraping the crop mucosal necrosis to make a smear, microscopic examination after staining, yeast-like fungi can be found.

Current prevention and control measures

 For the treatment of this disease, there is no good therapeutic drug clinically, and the curative effect of western medicine is poor, and it has strong dependence, large side effects, and easy recurrence. However, the commonly used local oral medicines, such as iodine glycerin, have no significant effect after application, and often the pain of suffering from goose aggravates and affects eating.

In order to overcome the above-mentioned shortcomings, the purpose of the present invention is to provide a kind of oral medicine for the treatment of gosling candidiasis and its preparation method. And without any side effects. the

Invention content :

The purpose of the present invention is to overcome the current shortcomings in the treatment of candidiasis in gooses, and provide a treatment for candida albicans in gooses that is easy to obtain, convenient to prepare, reduces drug residues and side effects, and is low in price and high in curative effect. Oral medicines for sickness.

An oral medicament for treating goose candidiasis, the components by weight are: 15-25 parts of white fresh skin, 12-18 parts of Patrinia, 12-18 parts of Cortex Phellodendri, 12-18 parts of Sophora flavescens, 8-12 parts of Qingdai, 6-8 parts of 1 million units/grammycin, 2-4 parts of borneol, 50-70 parts of mature vinegar. the

Preferred weight components are:

25 parts of white fresh skin, 12 parts of Patrinia, 18 parts of Cortex Phellodendri, 12 parts of Sophora flavescens, 12 parts of Qingdai, 6 parts of nystatin, 2 parts of borneol, 70 parts of mature vinegar.

or as:

15 parts of white fresh skin, 18 parts of Patrinia, 12 parts of Cortex Phellodendri, 18 parts of Sophora flavescens, 8 parts of Qingdai, 8 parts of nystatin, 4 parts of borneol, 50 parts of mature vinegar.

or as:

20 parts of white fresh skin, 15 parts of Patrinia, 15 parts of Cortex Phellodendri, 15 parts of Sophora flavescens, 10 parts of Qingdai, 7 parts of nystatin, 3 parts of borneol, 60 parts of mature vinegar.

Another object of the present invention is to provide a kind of oral medicine for the treatment of gosling candidiasis, which is prepared by the following method:

Weigh each component according to the raw material ratio of a oral medicine for the treatment of goose candidiasis albicans, crush the traditional Chinese medicine in it, pass through a 120-mesh sieve, grind nystatin tablets into powder and add physiological saline to prepare Make an aqueous suspension of 50,000 to 100,000 U/ml, mix it with other medicines, add mature vinegar, and stir continuously during the addition process to make the medicines mix evenly and fully dissolve into ointment, which can treat Candida albicans in goslings Sick oral cavity with traditional Chinese medicine composition ointment.

A kind of oral medicine for the treatment of gosling candidiasis albicans, in the prescription:

Radix Cortex: bitter; salty; cold. Return spleen, lung, small intestine, stomach, urinary bladder channel. Have heat-clearing and damp-drying; Expelling wind and relieving itching; The merit of detoxification. Indications: rubella caused by wind-heat-damp poisoning; eczema; scabies; jaundice; damp-heat arthralgia. In vitro tests have shown that it has different degrees of inhibitory effects on fungi, especially has a good therapeutic effect on candidiasis albicans, and has the effects of strengthening the heart and clearing away heat.

Patrinia: pungent, bitter, slightly cold. Return stomach, large intestine, Liver Channel. Have heat-clearing and toxic substances removing, eliminate carbuncle and expel pus, remove blood stasis and relieve pain. This product is pungent and bitter, expels cold and cool, can clear heat and detoxify, eliminate carbuncle and expel pus, and can activate blood and relieve pain, so it is the first choice drug for treating intestinal carbuncle and abdominal pain. It has inhibitory effect on a variety of pathogenic bacteria and viruses. It is commonly used in various acute infectious diseases. It can also be decocted and fumigated, or fresh products can be mashed and applied externally, especially for the treatment of thrush and other diseases to obtain satisfactory curative effect. It can also treat purulent skin diseases such as folliculitis and boils.

Cortex Phellodendri: bitter, cold. Return kidney, bladder, large intestine channel. It has the functions of clearing away heat and dampness, purging fire and detoxification, and reducing asthenic fever. In vitro tests have strong inhibitory effects on various pathogenic bacteria, especially strong antifungal effects, especially strong inhibitory effects on Candida albicans. It has a good therapeutic effect on treating sores and carbuncles, eczema, and eczema, especially for sores on the mouth and tongue; red eyes and swelling; carbuncles and sores, and other diseases. And there are anti-ulcer, diuretic, stomach invigorating, external use and other effects. Sophora flavescens: bitter, cold. Go into the heart, liver, stomach, large intestine, urinary bladder channel. It has the functions of clearing away heat and dampness, expelling wind, killing insects and diuresis. It has a good curative effect on jaundice and diarrhea caused by damp heat. etc. have a better therapeutic effect. Qingdai: salty, cold. Return liver channel. Have heat-clearing and toxic substances removing, the merit of cooling blood. It can be used for diseases such as febrile plaques, aphthous sores, mumps, etc. It has a good therapeutic effect on Candida goosebumps.

Borneol: pungent, bitter, slightly cold. Go into the heart, liver, spleen, lung meridian. It has the functions of clearing the orifices, dispersing stagnant fire, removing cloudiness and improving eyesight, reducing swelling and relieving pain, and is mainly used to treat febrile diseases, coma, sore throat, aphtha, carbuncle and other diseases. This product is bitter and cold, has the function of clearing away heat, relieving pain and reducing swelling.

Mature vinegar: sour, warm. Go into liver, stomach warp. It has the effects of dispelling blood stasis, hemostasis, detoxification, and killing insects. It has good antibacterial and bactericidal effects. It can effectively prevent some infectious diseases, soften blood vessels, and lower cholesterol. It also has a good protective effect on the skin when used externally. It is mostly used in some The treatment of carbuncle sores also has a good therapeutic effect on fungal infections.

Nystatin: Polyene antifungal drug with broad-spectrum antifungal effect and high antibacterial activity against Candida. This product can be combined with sterols on the fungal cell membrane, resulting in a change in the permeability of the cell membrane, resulting in the loss of important cell contents and exerting an antifungal effect.

The organic combination, dialectical compatibility and mutual assistance of the above-mentioned medicines enhance the efficacy of the prescription for clearing away heat and dampness, detoxifying and dispelling blood stasis, so as to achieve the purpose of curing oral lesions of goose candidiasis albicans. In particular, the medicine is directly injected into the oral lesions of the suffering goose, so as to directly exert the drug effect. The oral medicine for goose candidiasis prepared by the preparation method of the oral medicine for treating goose candidiasis has the advantages of low cost, easy preparation, no toxic and side effects, and remarkable curative effect. Clinical practice has proved that the drug has a cure rate of 96.68% and an effective rate of 100%. the

Detailed ways

Example 1

25 parts of white fresh skin, 12 parts of Patrinia, 18 parts of Cortex Phellodendri, 12 parts of Sophora flavescens, 12 parts of Qingdai, 6 parts of nystatin, 2 parts of borneol, 70 parts of mature vinegar.

or as:

Example 2

15 parts of white fresh skin, 18 parts of Patrinia, 12 parts of Cortex Phellodendri, 18 parts of Sophora flavescens, 8 parts of Qingdai, 8 parts of nystatin, 4 parts of borneol, 50 parts of mature vinegar.

Example 3

Components by weight: 20 parts of white fresh skin, 15 parts of Patrinia, 15 parts of Cortex Phellodendri, 15 parts of Sophora flavescens, 10 parts of Qingdai, 7 parts of nystatin, 3 parts of borneol, 60 parts of mature vinegar.

Example 4

Weigh according to the ratio of Example 1, 2 or 3, crush the Chinese medicine into fine powder, pass through a 120-mesh sieve for later use, grind nystatin tablets into powder and add physiological saline to prepare 50,000-100,000 U / ml of water suspension, mixed with crushed traditional Chinese medicine, and added mature vinegar, stirring continuously during the addition process, so that the medicine is mixed evenly, fully dissolved into ointment, and it can be used for oral treatment of goose candidiasis albicans Traditional Chinese medicine composition ointment.

Clinical Efficacy Trial

1. Method: Two farms where gosling albicans occurred were selected, and a total of 1287 goslings with oral lesions were selected, aged 3-4 weeks. The diseased goslings were divided into three groups, namely the present invention group, nystatin group and iodine glycerol group.

The group of the present invention is weighed according to the proportion of Example 3, after crushing the traditional Chinese medicine into fine powder, passing through a 120-mesh sieve for later use, grinding nystatin tablets into powder and adding physiological saline to prepare 50,000-100,000 U/s ml of water suspension, mixed with crushed traditional Chinese medicine, and added mature vinegar, stirring continuously during the addition process, so that the medicine is mixed evenly, fully dissolved into ointment, and the oral traditional Chinese medicine for the treatment of goose candidiasis albicans Composition ointment. Directly use a cotton ball dipped in the liquid to smear the surface of the affected goose with oral ulcers. the

In the nystatin group, nystatin tablets were ground into powder and added to normal saline to prepare an aqueous suspension of 50,000 to 100,000 U/ml, and the cotton ball was directly dipped in the liquid to smear the surface of the affected goose with oral ulcers. the

Iodine glycerin was purchased from Changchun Jilin Pharmacy and produced by Shanghai Yunjia Huangpu Pharmaceutical Co., Ltd. It contained 10 mg of iodine as the main component per milliliter, and was directly dipped in a cotton ball to take the liquid and smeared on the surface of the affected goose with oral ulcers. the

The treatment time is 5 days, and the medicine is applied once in the morning and afternoon every day. the

Table 1 Grouping of goslings and main treatment methods

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The cases in each group adopted the same overall treatment method while local oral medication was used. Nystatin was added to the feed. The drug was produced by Jinan Jiade New Veterinary Drug Raw Materials Co., Ltd. and mixed in at a dose of 1 million units per kilogram of feed. sky.

2. Judgment of curative effect:

Cure: gosling candidiasis albicans symptom and ulcer surface on oral mucosa and tongue surface disappear completely.

Improvement: The symptoms of candidiasis albicans and part of the oral mucosa and tongue ulcers disappeared. the

Ineffective: The symptoms of candidiasis albicans in goslings and ulcers on the oral mucosa and tongue remained unchanged. the

3. Results: 1287 goslings were treated with different dosing regimens. After three days of treatment, the treatment effects of each group are shown in Table 2. the

Table 2 The effect of various treatment schemes on goslings

It can be seen from Table 2 that the three drugs have different therapeutic effects on goose candidiasis, among which the group of the present invention has the best therapeutic effect, with a cure rate of 96.68% and a total effective rate of 100%, which is significantly higher than that of the other two groups ( P < 0. 01); followed by the nystatin group, followed by the iodine glycerin group, and the statistical results showed that there were significant differences among the groups ( P < 0. 05) .

For many years, adopt the proportioning of embodiment 1,2,3, the medicine prepared by the method of embodiment 4, treat the goslings of the breeding farm that takes place gosling candidiasis through many goslings, and cure rate is all about 96, and total The effective rates are all up to 100%. The medicine of the invention has the functions of removing putrefaction and promoting granulation, relieving pain, removing dampness, reducing inflammation and sterilizing, repairing ulcer surface, alleviating pain symptoms, promoting healing, and without any side effect. It has a good curative effect on the oral lesions of goose candidiasis albicans. A practical new drug is provided for the clinical treatment of the disease. the

Claims (4)

1. A medicine for oral cavity for the treatment of goose candidiasis, it is made of the medicine of following weight components: 15-25 parts of white fresh skin, 12-18 parts of Patrinia, 12-18 parts of Cortex Phellodendri, 12-18 parts of Sophora flavescens, 8-12 parts of Qingdai, 6-8 parts of nystatin, 2-4 parts of borneol, 50-70 parts of mature vinegar; After the traditional Chinese medicine is crushed and passed through a 120-mesh sieve, the nystatin tablets are ground into powder and added to normal saline to prepare an aqueous suspension of 50,000 to 100,000 U/ml and mixed with other medicines, and then add mature vinegar and stir Uniformly and fully dissolved into a paste. 2. A kind of oral medicine for the treatment of goose candidiasis according to claim 1, characterized in that, 25 parts of white fresh skin, 12 parts of Patrinia, 18 parts of Cortex Phellodendri, 12 parts of Sophora flavescens, 12 parts of Qingdai parts, 6 parts of nystatin, 2 parts of borneol, and 70 parts of mature vinegar. 3. A kind of oral medicine for the treatment of goose candidiasis according to claim 1, characterized in that 15 parts of white fresh skin, 18 parts of Patrinia, 12 parts of Cortex Phellodendri, 18 parts of Sophora flavescens, 8 parts of Qingdai 8 parts of nystatin, 4 parts of borneol, 50 parts of mature vinegar. 4. a kind of oral medicine for the treatment of goose candidiasis according to claim 1, is characterized in that, it is made of the medicine of following weight components: 20 parts of white fresh bark, 15 parts of Patrinia , 15 parts of Cortex Phellodendri, 15 parts of Sophora flavescens, 10 parts of Qingdai, 7 parts of nystatin, 3 parts of borneol, and 60 parts of mature vinegar.