CN102485247B - Traditional Chinese medicine composition used for treating gynecologic diseases, and preparation method thereof - Google Patents
Traditional Chinese medicine composition used for treating gynecologic diseases, and preparation method thereof Download PDFInfo
- Publication number
- CN102485247B CN102485247B CN201010580133.2A CN201010580133A CN102485247B CN 102485247 B CN102485247 B CN 102485247B CN 201010580133 A CN201010580133 A CN 201010580133A CN 102485247 B CN102485247 B CN 102485247B
- Authority
- CN
- China
- Prior art keywords
- radix sophorae
- sophorae flavescentis
- water
- weight
- filters
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention provides a traditional Chinese medicine composition used for treating gynecologic diseases such as cervicitis, and a preparation method thereof. The composition is prepared from tree-of-heaven ailanthus bark, lightyellow sophora root, frankincense, borneol, and tree peony root-bark. The cervicitis-treating traditional Chinese medicine composition provided by the invention provides functions of heat clearing, dampness removing, morbid leucorrhea stopping, itching relieving, necrotic tissue removing, granulation promoting, astringing, and bleeding stopping. The medicine composition can be widely applied for treating gynecologic diseases caused by pathogens such as bacteria, fungi, protozoan, chlamydia, mycoplasma, and the like. Also, the medicine has an effect as a pH buffering agent. Through the regulation upon the vagina pH, a vagina self-cleaning function can be recovered.
Description
Technical field
The present invention relates to field of medicaments, specifically, relate to a kind of Chinese medicine composition for the treatment of the gynaecopathias such as cervicitis and preparation method thereof.
Background technology
Cervicitis is clinical one group of common clinical disease.Cervical erosion is the main local patholoic change in chronic cervicitis, is commonly encountered diseases, the frequently-occurring disease of gynecological.Its sickness rate accounts for the more than 50% of gynaecopathia.Show after deliberation, cervical erosion and cervical cancer have an important relationship.The cervical cancer variability of patients of cervical ruin is 2.5%, and more non-patients of cervical ruin is high 6 times.
Doctor trained in Western medicine thinks, cervical erosion is the modal clinical manifestation of chronic cervicitis.Its cause of disease mostly is long-term chronic mechanical irritation and damage, if childbirth, miscarriage or surgical injury etc. are main root inducement, cause pathogen to be invaded and cause not active treatment of acute infection period, gradually form chronic cervicitis, make cervix uteri mainly produce rotten to the corn pathological change.On cervical erosion pathology, think it is mainly that the squamous epithelial cancer on cervix uteri surface comes off, by columnar epithelium is replaced, the result that upper veins beneath the skin appears.Research in recent years show again cervical erosion and whole body immunologic mechanism, have great relation.Result shows, being related closely of the infection of HPV 16 (HPV-16), human herpesvirus 2's type (HSV-2) cytomegalovirus (CMV) and chlamydia trachomatis (CT) and cervical erosion.When after viral infection body cell, can directly exert an influence to immunity of organism, this impact comprises two aspects: the one, immunosuppressant, the 2nd, immunological enhancement, and take immunosuppressant as main.
Western medical treatment cervical erosion, first-selected physiotherapy, is secondly external used medicine.Prolonged application physiotherapy can produce a lot of side effect, and easily recurrence after treating, and has again contraindication simultaneously; Western medicine medicine for external use mostly is corrosive medicine, and the focus shallow to comparison sheet, Area comparison is little has certain effect, but treatment is how not thorough, and long-term prescription and naturopathy can cause many side effect, and remove and stop rear easy recurrence.
Motherland's medical science thinks that it is in noxious dampness, to invade and the damp-heat gluing each other multiple abscess part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels that cervical erosion forms reason, causes conception vessel not solid, and dai channel is failed to keep an appointment, and vessels of the uterus is qi-blood disharmony, the local QI and blood retardance of cervix uteri, and the evil stasis of blood causes corruption.Show through modern Chinese medicine research, cervical erosion cause of disease complexity, but it be mainly damp is main, sick position is at uterus, dirty in close relations with spleen kidney two, and pathogenesis is mainly damp damage and appoints, is with two arteries and veins, vessels of the uterus is qi-blood disharmony, with the passing of time cervical orifice of uterus part long-pending, the pyretic toxicity of the damp and hot stasis of blood stop up stagnant, blood stasis and cause corruption.Simultaneously modern also have expert to think that cervical erosion and liver also have certain relation.Dampness-heat of the liver bet, can appoint band passages through which vital energy circulates by coup injury, and cause primary disease.As fully visible, damp has important effect in the pathogenic process of cervical erosion, so the treatment of cervical erosion is engaged in damp eliminating.In recent years, traditional Chinese medical science worker has carried out a large amount of observations to the effectiveness of Chinese medicine cervical erosion, result shows, Chinese medicine has good therapeutical effect for cervical erosion, and can reduce side effect and the recurrence rate of physiotherapy, Chinese traditional treatment cervical erosion becomes one of method generally adopting clinically thus.
Because its sick bit comparison is special, endo-medicine effect is slower, is not easy to through sick position, so the traditional Chinese medical science mostly in recent years is external treatment to the treatment of cervical erosion.Conclude bibliographical information in recent years, the Chinese medicine of conventional external treatment cervical erosion is roughly divided into following a few class: 1. removing dampness, detumescence, sore, putrefaction removing, granulation promoting medicine; 2. heat clearing away, removing toxic substances, dampness, blood-cooling drugs; 3. invigorate blood circulation, blood stasis dispelling, loose swollen medicine.Dosage form mostly is powder, suppository, pill, tablet, unguentum, paste etc.As can be seen here, treatment cervical erosion medication will be take dampness or damp eliminating medicine as main, and is aided with promoting blood circulation and cooling blood, and promoting tissue regeneration and ulcer healing medicine is main.
Summary of the invention
The object of this invention is to provide a kind of Chinese medicine composition for the treatment of the gynaecopathias such as vaginitis, cervicitis, cervical erosion and preparation method thereof.
In order to realize the object of the invention, a kind of Chinese medicine composition for the treatment of gynaecopathia of the present invention, comprises the crude drug of following weight proportioning: Cortex Ailanthi 35～45, Radix Sophorae Flavescentis 23～35, Olibanum 25～35, Borneolum Syntheticum 0.8～1.2, Cortex Moutan 25～35.
Preferably, a kind of Chinese medicine composition for the treatment of gynaecopathia of the present invention, comprises the crude drug of following weight proportioning: Cortex Ailanthi 40, Radix Sophorae Flavescentis 30, Olibanum 30, Borneolum Syntheticum 1, Cortex Moutan 30.
Aforesaid Chinese medicine composition, it is effervescent tablet, effervescent capsule, effervescent granule, washing liquid, suppository or gel.Wherein, in preparation, carrier used is conventional carrier, and conventional disintegrating agent is as sodium bicarbonate and citric acid, polyethylene glycol 6000 etc., and excipient is as dextrin, micropowder silica gel mixture, microcrystalline Cellulose, greasing base etc.
The method of preparing aforementioned Chinese medicine composition effervescent tablet, comprises the steps:
1) Cortex Ailanthi decocts with water 1-3 time, adds altogether the water of 2-9 times of Cortex Ailanthi weight, decocts 1-2.5 hour at every turn, and collecting decoction filters, and it is 1.05～1.10 Cortex Ailanthi clear paste that filtrate decompression is concentrated into relative density;
2) the Radix Sophorae Flavescentis 0.5-1.5 hour that is soaked in water, Radix Sophorae Flavescentis after soaking is decocted with water 1-3 time, add altogether the water of 6-12 times of Radix Sophorae Flavescentis weight, each 0.5-3 hour that decocts, collecting decoction, filters, and filtrate decompression is concentrated into the Radix Sophorae Flavescentis clear paste of relative density 1.10～1.15, let cool, add ethanol and make to reach 60-70wt% containing alcohol amount, leave standstill 8-24 hour, filter, filtrate recycling ethanol is extremely without alcohol taste, with step 1) in the Cortex Ailanthi clear paste that obtains merge, be concentrated into the clear paste of relative density 1.05～1.10, dry, be ground into fine powder, for subsequent use;
3) Olibanum adds the water of 6-10 times of weight, and distillation 5-9 hour, collects volatile oil;
4) Cortex Moutan distills with steam distillation, collects the distillate of 4-8 times of Cortex Moutan weight, places crystallize, filters, and the paeonol crystallization obtaining is separately put; Aqueous solution redistillation, collects the distillate of 2-4 times of Cortex Moutan weight, places crystallize, filters, and merges paeonol crystallization;
5) get Borneolum Syntheticum, step 4) in the paeonol crystallization that obtains with after a small amount of dissolve with ethanol, add step 3) in the volatile oil of the Olibanum that obtains, by Borneolum Syntheticum, paeonol crystallization and Olibanum volatile oil: beta-schardinger dextrin-: the weight ratio that water is 1: 8: 80, stir and within 1 hour, carry out inclusion at 60 ℃, cold preservation is spent the night, and filters, and inclusion complex is 40 ℃ of cold drying, be ground into fine powder, for subsequent use;
6) by step 2) in the Cortex Ailanthi, the Radix Sophorae Flavescentis fine powder that obtain, with step 5) the inclusion complex fine powder that makes mixes, and adds adipic acid and sodium bicarbonate and mannitol appropriate, mixes, and granulates, tabletting, to obtain final product.
The method of preparing aforementioned Chinese medicine composition effervescent capsule, comprises the steps:
1) Cortex Ailanthi decocts with water 1-3 time, adds altogether the water of 2-9 times of Cortex Ailanthi weight, decocts 1-2.5 hour at every turn, and collecting decoction filters, and it is 1.05～1.10 Cortex Ailanthi clear paste that filtrate decompression is concentrated into relative density;
2) the Radix Sophorae Flavescentis 0.5-1.5 hour that is soaked in water, Radix Sophorae Flavescentis after soaking is decocted with water 1-3 time, add altogether the water of 6-12 times of Radix Sophorae Flavescentis weight, each 0.5-3 hour that decocts, collecting decoction, filters, and filtrate decompression is concentrated into the Radix Sophorae Flavescentis clear paste of relative density 1.10～1.15, let cool, add ethanol and make to reach 60-70wt% containing alcohol amount, leave standstill 8-24 hour, filter, filtrate recycling ethanol is extremely without alcohol taste, with step 1) in the Cortex Ailanthi clear paste that obtains merge, be concentrated into the clear paste of relative density 1.05～1.10, dry, be ground into fine powder, for subsequent use;
3) Olibanum adds the water of 6-10 times of weight, and distillation 5-9 hour, collects volatile oil;
4) Cortex Moutan distills with steam distillation, collects the distillate of 4-8 times of Cortex Moutan weight, places crystallize, filters, and the paeonol crystallization obtaining is separately put; Aqueous solution redistillation, collects the distillate of 2-4 times of Cortex Moutan weight, places crystallize, filters, and merges paeonol crystallization;
5) get Borneolum Syntheticum, step 4) in the paeonol crystallization that obtains with after a small amount of dissolve with ethanol, add step 3) in the volatile oil of the Olibanum that obtains, by Borneolum Syntheticum, paeonol crystallization and Olibanum volatile oil: beta-schardinger dextrin-: the weight ratio that water is 1: 8: 80, stir and within 1 hour, carry out inclusion at 60 ℃, cold preservation is spent the night, and filters, and inclusion complex is 40 ℃ of cold drying, be ground into fine powder, for subsequent use;
6) by step 2) in the Cortex Ailanthi, the Radix Sophorae Flavescentis fine powder that obtain, with step 5) the inclusion complex fine powder that makes mixes, and adds adipic acid and sodium bicarbonate and mannitol appropriate, mixes, and granulates, encapsulated, to obtain final product.
The method of preparing aforementioned Chinese medicine composition effervescent granule, comprises the steps:
1) Cortex Ailanthi decocts with water 1-3 time, adds altogether the water of 2-9 times of Cortex Ailanthi weight, decocts 1-2.5 hour at every turn, and collecting decoction filters, and it is 1.05～1.10 Cortex Ailanthi clear paste that filtrate decompression is concentrated into relative density;
2) the Radix Sophorae Flavescentis 0.5-1.5 hour that is soaked in water, Radix Sophorae Flavescentis after soaking is decocted with water 1-3 time, add altogether the water of 6-12 times of Radix Sophorae Flavescentis weight, each 0.5-3 hour that decocts, collecting decoction, filters, and filtrate decompression is concentrated into the Radix Sophorae Flavescentis clear paste of relative density 1.10～1.15, let cool, add ethanol and make to reach 60-70wt% containing alcohol amount, leave standstill 8-24 hour, filter, filtrate recycling ethanol is extremely without alcohol taste, with step 1) in the Cortex Ailanthi clear paste that obtains merge, be concentrated into the clear paste of relative density 1.05～1.10, dry, be ground into fine powder, for subsequent use;
3) Olibanum adds the water of 6-10 times of weight, and distillation 5-9 hour, collects volatile oil;
4) Cortex Moutan distills with steam distillation, collects the distillate of 4-8 times of Cortex Moutan weight, places crystallize, filters, and the paeonol crystallization obtaining is separately put; Aqueous solution redistillation, collects the distillate of 2-4 times of Cortex Moutan weight, places crystallize, filters, and merges paeonol crystallization;
5) get Borneolum Syntheticum, step 4) in the paeonol crystallization that obtains with after a small amount of dissolve with ethanol, add step 3) in the volatile oil of the Olibanum that obtains, by Borneolum Syntheticum, paeonol crystallization and Olibanum volatile oil: beta-schardinger dextrin-: the weight ratio that water is 1: 8: 80, stir and within 1 hour, carry out inclusion at 60 ℃, cold preservation is spent the night, and filters, and inclusion complex is 40 ℃ of cold drying, be ground into fine powder, for subsequent use;
6) by step 2) in the Cortex Ailanthi, the Radix Sophorae Flavescentis fine powder that obtain, with step 5) the inclusion complex fine powder that makes mixes, and adds adipic acid and sodium bicarbonate and mannitol appropriate, mixes, and granulates, subpackage, to obtain final product.
The method of preparing aforementioned Chinese medicine composition washing liquid, is characterized in that, comprises the steps:
1) Cortex Ailanthi decocts with water 1-3 time, adds altogether the water of 2-9 times of Cortex Ailanthi weight, decocts 1-2.5 hour at every turn, and collecting decoction filters, and it is 1.05～1.10 Cortex Ailanthi clear paste that filtrate decompression is concentrated into relative density;
2) the Radix Sophorae Flavescentis 0.5-1.5 hour that is soaked in water, Radix Sophorae Flavescentis after soaking is decocted with water 1-3 time, add altogether the water of 6-12 times of Radix Sophorae Flavescentis weight, each 0.5-3 hour that decocts, collecting decoction, filters, and filtrate decompression is concentrated into the Radix Sophorae Flavescentis clear paste of relative density 1.10～1.15, let cool, add ethanol and make to reach 60-70wt% containing alcohol amount, leave standstill 8-24 hour, filter, filtrate recycling ethanol is extremely without alcohol taste, with step 1) in the Cortex Ailanthi clear paste that obtains merge, be concentrated into the clear paste of relative density 1.05～1.10, dry, be ground into fine powder, for subsequent use;
3) Olibanum adds the water of 6-10 times of weight, and distillation 5-9 hour, collects volatile oil;
4) Cortex Moutan distills with steam distillation, collects the distillate of 4-8 times of Cortex Moutan weight, places crystallize, filters, and the paeonol crystallization obtaining is separately put; Aqueous solution redistillation, collects the distillate of 2-4 times of Cortex Moutan weight, places crystallize, filters, and merges paeonol crystallization;
5) get Borneolum Syntheticum, step 4) in the paeonol crystallization that obtains with after a small amount of dissolve with ethanol, add step 3) in the volatile oil of the Olibanum that obtains, with step 2) Cortex Ailanthi, the Radix Sophorae Flavescentis clear paste that make mix homogeneously, add again polyoxyethylene sorbitan monoleate and sodium benzoate appropriate, add water and be settled to 1000ml, to obtain final product.
The method of preparing aforementioned Chinese medicine composition suppository, is characterized in that, comprises the steps:
1) Cortex Ailanthi decocts with water 1-3 time, adds altogether the water of 2-9 times of Cortex Ailanthi weight, decocts 1-2.5 hour at every turn, and collecting decoction filters, and it is 1.05～1.10 Cortex Ailanthi clear paste that filtrate decompression is concentrated into relative density;
2) the Radix Sophorae Flavescentis 0.5-1.5 hour that is soaked in water, Radix Sophorae Flavescentis after soaking is decocted with water 1-3 time, add altogether the water of 6-12 times of Radix Sophorae Flavescentis weight, each 0.5-3 hour that decocts, collecting decoction, filters, and filtrate decompression is concentrated into the Radix Sophorae Flavescentis clear paste of relative density 1.10～1.15, let cool, add ethanol and make to reach 60-70wt% containing alcohol amount, leave standstill 8-24 hour, filter, filtrate recycling ethanol is extremely without alcohol taste, with step 1) in the Cortex Ailanthi clear paste that obtains merge, be concentrated into the clear paste of relative density 1.05～1.10, dry, be ground into fine powder, for subsequent use;
3) Olibanum adds the water of 6-10 times of weight, and distillation 5-9 hour, collects volatile oil;
4) Cortex Moutan distills with steam distillation, collects the distillate of 4-8 times of Cortex Moutan weight, places crystallize, filters, and the paeonol crystallization obtaining is separately put; Aqueous solution redistillation, collects the distillate of 2-4 times of Cortex Moutan weight, places crystallize, filters, and merges paeonol crystallization;
5) get Borneolum Syntheticum, step 4) in the paeonol crystallization that obtains with after a small amount of dissolve with ethanol, add step 3) in the volatile oil of the Olibanum that obtains, by Borneolum Syntheticum, paeonol crystallization and Olibanum volatile oil: beta-schardinger dextrin-: the weight ratio that water is 1: 8: 80, stir and within 1 hour, carry out inclusion at 60 ℃, cold preservation is spent the night, and filters, and inclusion complex is 40 ℃ of cold drying, be ground into fine powder, for subsequent use;
6) by step 2) in the Cortex Ailanthi, the Radix Sophorae Flavescentis fine powder that obtain, with step 5) the inclusion complex fine powder that makes mixes, and adds gelatin: glycerol: the substrate that mannitol is mixed with by the weight ratio of 2: 5: 6, make suppository, to obtain final product.
Chinese medicine composition of the present invention is the compound Chinese medicinal preparation with theory of Chinese medical science prescription, both many deficiencies of chemical drugs can have been overcome, can bring into play again the incomparable many-sided therapeutical effect of chemical drugs (as removing damp-heat, leukorrhagia stopping is antipruritic, putrefaction-removing granulation-promoting, astringing to arrest bleeding etc.), can be widely used in antibacterial, fungus, protozoon, chlamydia, the former caused gynecological inflammation that causes a disease such as mycoplasma, simultaneously, this Chinese traditional compound medicine also has the effect of pH buffer agent, by regulating vagina pH, vagina self-cleaning function is recovered, suppress the growth and breeding of pathogenic microorganism or protozoon by self-cleaning system, in addition, Chinese medicine composition provided by the invention is better than Western medicine far away to the comprehensive inhibitory action of virus.Therefore, aspect treatment gynecological inflammation, exploitation determined curative effect, the pure Chinese medicinal preparation of dosage form novelty has wide market prospect.
The specific embodiment
Following examples are used for illustrating the present invention, but are not used for limiting the scope of the invention.
Embodiment 1 Chinese medicine composition effervescent tablet of the present invention
I preparation method
The following raw material medicaments of weighing: Cortex Ailanthi 1750g, Radix Sophorae Flavescentis 1750g, Olibanum 1250g, Borneolum Syntheticum 60g, Cortex Moutan 1250g.
Preparation process comprises:
1) Cortex Ailanthi decocts with water 3 times, adds altogether the water of 9 times of Cortex Ailanthi weight, decocts 2.5 hours at every turn, and collecting decoction, filters, and it is 1.05～1.10 Cortex Ailanthi clear paste that filtrate decompression is concentrated into relative density;
2) be soaked in water Radix Sophorae Flavescentis 1.5 hours, decocts with water the Radix Sophorae Flavescentis after soaking 3 times, adds altogether the water of 12 times of Radix Sophorae Flavescentis weight, each decoction 3 hours, collecting decoction, filters, filtrate decompression is concentrated into the Radix Sophorae Flavescentis clear paste of relative density 1.10～1.15, lets cool, and adds ethanol and makes to reach 70wt% containing alcohol amount, leave standstill 24 hours, filter, filtrate recycling ethanol is extremely without alcohol taste, with step 1) in the Cortex Ailanthi clear paste that obtains merge, be concentrated into the clear paste of relative density 1.05～1.10, dry, be ground into fine powder, for subsequent use;
3) Olibanum adds the water of 10 times of weight, distills 9 hours, collects volatile oil;
4) Cortex Moutan distills with steam distillation, collects the distillate of 8 times of Cortex Moutan weight, places crystallize, filters, and the paeonol crystallization obtaining is separately put; Aqueous solution redistillation, collects the distillate of 4 times of Cortex Moutan weight, places crystallize, filters, and merges paeonol crystallization;
5) get Borneolum Syntheticum, step 4) in the paeonol crystallization that obtains with after a small amount of dissolve with ethanol, add step 3) in the volatile oil of the Olibanum that obtains, by Borneolum Syntheticum, paeonol crystallization and Olibanum volatile oil: beta-schardinger dextrin-: the weight ratio that water is 1: 8: 80, stir and within 1 hour, carry out inclusion at 60 ℃, cold preservation is spent the night, and filters, and inclusion complex is 40 ℃ of cold drying, be ground into fine powder, for subsequent use;
6) by step 2) in the Cortex Ailanthi, the Radix Sophorae Flavescentis fine powder that obtain, with step 5) the inclusion complex fine powder that makes mixes, and adds adipic acid 260g and sodium bicarbonate 200g and mannitol 20g, mixes, and granulates, tabletting, to obtain final product.
Embodiment 2 Chinese medicine composition effervescent of the present invention capsule
I preparation method
The following raw material medicaments of weighing: Cortex Ailanthi 2250g, Radix Sophorae Flavescentis 1150g, Olibanum 1750g, Borneolum Syntheticum 40g, Cortex Moutan 1750g.
Preparation process comprises:
1) add the decocting of 2 times of Cortex Ailanthi weight to boil 1 hour, filter decocting liquid, it is 1.05～1.10 Cortex Ailanthi clear paste that filtrate decompression is concentrated into relative density;
2) be soaked in water Radix Sophorae Flavescentis 0.5 hour, adds the decocting of 6 times of Radix Sophorae Flavescentis weight to boil 0.5 hour the Radix Sophorae Flavescentis after soaking, and filters decocting liquid, filtrate decompression is concentrated into the Radix Sophorae Flavescentis clear paste of relative density 1.10～1.15, lets cool, and adds ethanol and makes to reach 60wt% containing alcohol amount, leave standstill 8 hours, filter, filtrate recycling ethanol is to without alcohol taste, with step 1) in the Cortex Ailanthi clear paste that obtains merge, be concentrated into the clear paste of relative density 1.05～1.10, dry, pulverize into fine powder, for subsequent use;
3) Olibanum adds the water of 6 times of weight, distills 5 hours, collects volatile oil;
4) Cortex Moutan distills with steam distillation, collects the distillate of 4 times of Cortex Moutan weight, places crystallize, filters, and the paeonol crystallization obtaining is separately put; Aqueous solution redistillation, collects the distillate of 2 times of Cortex Moutan weight, places crystallize, filters, and merges paeonol crystallization;
5) get Borneolum Syntheticum, step 4) in the paeonol crystallization that obtains with after a small amount of dissolve with ethanol, add step 3) in the volatile oil of the Olibanum that obtains, by Borneolum Syntheticum, paeonol crystallization and Olibanum volatile oil: beta-schardinger dextrin-: the weight ratio that water is 1: 8: 80, stir and within 1 hour, carry out inclusion at 60 ℃, cold preservation is spent the night, and filters, and inclusion complex is 40 ℃ of cold drying, be ground into fine powder, for subsequent use;
6) by step 2) in the Cortex Ailanthi, the Radix Sophorae Flavescentis fine powder that obtain, with step 5) the inclusion complex fine powder that makes mixes, and adds adipic acid 220g and sodium bicarbonate 180g and mannitol 20g, mixes, and granulates, encapsulated, to obtain final product.
Embodiment 3 Chinese medicine composition effervescent granule of the present invention
I preparation method
The following raw material medicaments of weighing: Cortex Ailanthi 2000g, Radix Sophorae Flavescentis 1500g, Olibanum 1500g, Borneolum Syntheticum 50g, Cortex Moutan 1500g.
Preparation process comprises:
1) Cortex Ailanthi decocts with water 2 times, adds altogether the water of 6 times of Cortex Ailanthi weight, decocts 1.5 hours at every turn, and collecting decoction, filters, and it is 1.05～1.10 Cortex Ailanthi clear paste that filtrate decompression is concentrated into relative density;
2) be soaked in water Radix Sophorae Flavescentis 1 hour, decocts with water the Radix Sophorae Flavescentis after soaking 2 times, adds altogether the water of 9 times of Radix Sophorae Flavescentis weight, each decoction 2 hours, collecting decoction, filters, filtrate decompression is concentrated into the Radix Sophorae Flavescentis clear paste of relative density 1.10～1.15, lets cool, and adds ethanol and makes to reach 65wt% containing alcohol amount, leave standstill 16 hours, filter, filtrate recycling ethanol is extremely without alcohol taste, with step 1) in the Cortex Ailanthi clear paste that obtains merge, be concentrated into the clear paste of relative density 1.05～1.10, dry, be ground into fine powder, for subsequent use;
3) Olibanum adds the water of 8 times of weight, distills 7 hours, collects volatile oil;
4) Cortex Moutan distills with steam distillation, collects the distillate of 6 times of Cortex Moutan weight, places crystallize, filters, and the paeonol crystallization obtaining is separately put; Aqueous solution redistillation, collects the distillate of 3 times of Cortex Moutan weight, places crystallize, filters, and merges paeonol crystallization;
5) get Borneolum Syntheticum, step 4) in the paeonol crystallization that obtains with after a small amount of dissolve with ethanol, add step 3) in the volatile oil of the Olibanum that obtains, by Borneolum Syntheticum, paeonol crystallization and Olibanum volatile oil: beta-schardinger dextrin-: the weight ratio that water is 1: 8: 80, stir and within 1 hour, carry out inclusion at 60 ℃, cold preservation is spent the night, and filters, and inclusion complex is 40 ℃ of cold drying, be ground into fine powder, for subsequent use;
6) by step 2) in the Cortex Ailanthi, the Radix Sophorae Flavescentis fine powder that obtain, with step 5) the inclusion complex fine powder that makes mixes, and adds adipic acid 240g and sodium bicarbonate 200g and mannitol 20g, mixes, and granulates, subpackage, to obtain final product.
Embodiment 4 Chinese medicine composition washing liquid of the present invention
I preparation method
The following raw material medicaments of weighing: Cortex Ailanthi 1750g, Radix Sophorae Flavescentis 1150g, Olibanum 1250g, Borneolum Syntheticum 40g, Cortex Moutan 1250g.
Preparation process comprises:
1) add the decocting of 2 times of Cortex Ailanthi weight to boil 1 hour, filter decocting liquid, it is 1.05～1.10 Cortex Ailanthi clear paste that filtrate decompression is concentrated into relative density;
2) be soaked in water Radix Sophorae Flavescentis 0.5 hour, adds the decocting of 6 times of Radix Sophorae Flavescentis weight to boil 0.5 hour the Radix Sophorae Flavescentis after soaking, and filters decocting liquid, filtrate decompression is concentrated into the Radix Sophorae Flavescentis clear paste of relative density 1.10～1.15, lets cool, and adds ethanol and makes to reach 60wt% containing alcohol amount, leave standstill 8 hours, filter, filtrate recycling ethanol is to without alcohol taste, with step 1) in the Cortex Ailanthi clear paste that obtains merge, be concentrated into the clear paste of relative density 1.05～1.10, dry, pulverize into fine powder, for subsequent use;
3) Olibanum adds the water of 6 times of weight, distills 5 hours, collects volatile oil;
4) Cortex Moutan distills with steam distillation, collects the distillate of 4 times of Cortex Moutan weight, places crystallize, filters, and the paeonol crystallization obtaining is separately put; Aqueous solution redistillation, collects the distillate of 2 times of Cortex Moutan weight, places crystallize, filters, and merges paeonol crystallization;
5) get Borneolum Syntheticum, step 4) in the paeonol crystallization that obtains with after a small amount of dissolve with ethanol, add step 3) in the volatile oil of the Olibanum that obtains, with step 2) Cortex Ailanthi, the Radix Sophorae Flavescentis clear paste that make mix homogeneously, add again polyoxyethylene sorbitan monoleate 120g and sodium benzoate 60g, add water and be settled to 1000ml, to obtain final product.
Embodiment 5 Chinese medicine composition suppository of the present invention
I preparation method
The following raw material medicaments of weighing: Cortex Ailanthi 2250g, Radix Sophorae Flavescentis 1750g, Olibanum 1750g, Borneolum Syntheticum 60g, Cortex Moutan 1750g.
Preparation process comprises:
1) Cortex Ailanthi decocts with water 3 times, adds altogether the water of 9 times of Cortex Ailanthi weight, decocts 2.5 hours at every turn, and collecting decoction, filters, and it is 1.05～1.10 Cortex Ailanthi clear paste that filtrate decompression is concentrated into relative density;
2) be soaked in water Radix Sophorae Flavescentis 1.5 hours, decocts with water the Radix Sophorae Flavescentis after soaking 3 times, adds altogether the water of 12 times of Radix Sophorae Flavescentis weight, each decoction 3 hours, collecting decoction, filters, filtrate decompression is concentrated into the Radix Sophorae Flavescentis clear paste of relative density 1.10～1.15, lets cool, and adds ethanol and makes to reach 70wt% containing alcohol amount, leave standstill 24 hours, filter, filtrate recycling ethanol is extremely without alcohol taste, with step 1) in the Cortex Ailanthi clear paste that obtains merge, be concentrated into the clear paste of relative density 1.05～1.10, dry, be ground into fine powder, for subsequent use;
3) Olibanum adds the water of 10 times of weight, distills 9 hours, collects volatile oil;
4) Cortex Moutan distills with steam distillation, collects the distillate of 8 times of Cortex Moutan weight, places crystallize, filters, and the paeonol crystallization obtaining is separately put; Aqueous solution redistillation, collects the distillate of 4 times of Cortex Moutan weight, places crystallize, filters, and merges paeonol crystallization;
5) get Borneolum Syntheticum, step 4) in the paeonol crystallization that obtains with after a small amount of dissolve with ethanol, add step 3) in the volatile oil of the Olibanum that obtains, by Borneolum Syntheticum, paeonol crystallization and Olibanum volatile oil: beta-schardinger dextrin-: the weight ratio that water is 1: 8: 80, stir and within 1 hour, carry out inclusion at 60 ℃, cold preservation is spent the night, and filters, and inclusion complex is 40 ℃ of cold drying, be ground into fine powder, for subsequent use;
6) by step 2) in the Cortex Ailanthi, the Radix Sophorae Flavescentis fine powder that obtain, with step 5) the inclusion complex fine powder that makes mixes, and adds the substrate being mixed with by 20g gelatin, 50g glycerol, 60g mannitol, makes suppository, to obtain final product.
II investigates the effect of Chinese medicine composition suppository in treatment gynaecopathia of the present invention.
1, case selection
Medical female gynecological disease patient 120 examples of 2008-2009 Nian Mou institute of traditional Chinese medicine, age 18-50 year.
2, group technology
The medical patient of 120 example is divided into 5 treatment groups and 1 matched group, every group of 20 examples at random.
3, Therapeutic Method
3.1 treatment group
According to the description of embodiment 1, make Chinese medicine composition effervescent tablet of the present invention, each 3,2 externals every day, were a course for the treatment of with 4 weeks continuously, observe the curative effect after 2 courses for the treatment of.
According to the description of embodiment 2, make Chinese medicine composition effervescent capsule of the present invention, each 3,2 externals every day, were a course for the treatment of with 4 weeks continuously, observe the curative effect after 2 courses for the treatment of.
According to the description of embodiment 3, make Chinese medicine composition effervescent granule of the present invention, each 15g, 2 externals every day, were a course for the treatment of with 4 weeks continuously, observe the curative effect after 2 courses for the treatment of.
According to the description of embodiment 4, make Chinese medicine composition washing liquid of the present invention, each 15ml, 2 externals every day, were a course for the treatment of with 4 weeks continuously, observe the curative effect after 2 courses for the treatment of.
According to the description of embodiment 5, make Chinese medicine composition suppository of the present invention, each 1 piece, 2 externals every day, were a course for the treatment of with 4 weeks continuously, observe the curative effect after 2 courses for the treatment of.
3.2 matched group
The Chinese medicine composition suppository of commercially available common treatment gynaecopathia.Each 1 piece, 2 externals every day, were a course for the treatment of with 4 weeks continuously, observe the curative effect after 2 courses for the treatment of.
4, experimental result
Clinical efficacy: the comparison of two groups of patient's curative effects, result is as shown in table 1.
Curative effect comparison before and after table 1 liang group patient treatment
*with relatively P < 0.01 of matched group, there is significant difference
Between group, comparative result shows, the improvement for the treatment of group gynaecopathia symptom is obviously better than matched group.
Although above the present invention is described in detail with a general description of the specific embodiments, on basis of the present invention, can make some modifications or improvements it, this will be apparent to those skilled in the art.Therefore, these modifications or improvements without departing from theon the basis of the spirit of the present invention, all belong to the scope of protection of present invention.
Claims (5)
1. the method for the Chinese medicine composition effervescent tablet of preparation treatment gynaecopathia, the crude drug of use is: Cortex Ailanthi 1750g, Radix Sophorae Flavescentis 1750g, Olibanum 1250g, Borneolum Syntheticum 60g, Cortex Moutan 1250g, it is characterized in that, comprise the steps:
1) Cortex Ailanthi decocts with water 3 times, adds altogether the water of 9 times of Cortex Ailanthi weight, decocts 2.5 hours at every turn, and collecting decoction, filters, and it is 1.05～1.10 Cortex Ailanthi clear paste that filtrate decompression is concentrated into relative density;
2) be soaked in water Radix Sophorae Flavescentis 1.5 hours, decocts with water the Radix Sophorae Flavescentis after soaking 3 times, adds altogether the water of 12 times of Radix Sophorae Flavescentis weight, each decoction 3 hours, collecting decoction, filters, filtrate decompression is concentrated into the Radix Sophorae Flavescentis clear paste of relative density 1.10～1.15, lets cool, and adds ethanol and makes to reach 70wt% containing alcohol amount, leave standstill 24 hours, filter, filtrate recycling ethanol is extremely without alcohol taste, merge with the Cortex Ailanthi clear paste obtaining in step 1), be concentrated into the clear paste of relative density 1.05～1.10, dry, be ground into fine powder, for subsequent use;
3) Olibanum adds the water of 10 times of weight, distills 9 hours, collects volatile oil;
4) Cortex Moutan distills with steam distillation, collects the distillate of 8 times of Cortex Moutan weight, places crystallize, filters, and the paeonol crystallization obtaining is separately put; Aqueous solution redistillation, collects the distillate of 4 times of Cortex Moutan weight, places crystallize, filters, and merges paeonol crystallization;
5) get the paeonol crystallization obtaining in Borneolum Syntheticum, step 4) with after a small amount of dissolve with ethanol, add the volatile oil of the Olibanum obtaining in step 3), by Borneolum Syntheticum, paeonol crystallization and Olibanum volatile oil: beta-schardinger dextrin-: the weight ratio that water is 1:8:80, stir and within 1 hour, carry out inclusion at 60 ℃, cold preservation is spent the night, and filters, and inclusion complex is 40 ℃ of cold drying, be ground into fine powder, for subsequent use;
6) by step 2) in the Cortex Ailanthi, the Radix Sophorae Flavescentis fine powder that obtain, the inclusion complex fine powder making with step 5) mixes, and adds adipic acid 260g and sodium bicarbonate 200g and mannitol 20g, mixes, and granulates, tabletting, to obtain final product.
2. the method for the Chinese medicine composition effervescent capsule of preparation treatment gynaecopathia, the crude drug of use is: Cortex Ailanthi 2250g, Radix Sophorae Flavescentis 1150g, Olibanum 1750g, Borneolum Syntheticum 40g, Cortex Moutan 1750g, it is characterized in that, comprise the steps:
1) add the decocting of 2 times of Cortex Ailanthi weight to boil 1 hour, filter decocting liquid, it is 1.05～1.10 Cortex Ailanthi clear paste that filtrate decompression is concentrated into relative density;
2) be soaked in water Radix Sophorae Flavescentis 0.5 hour, adds the decocting of 6 times of Radix Sophorae Flavescentis weight to boil 0.5 hour the Radix Sophorae Flavescentis after soaking, and filters decocting liquid, filtrate decompression is concentrated into the Radix Sophorae Flavescentis clear paste of relative density 1.10～1.15, lets cool, and adds ethanol and makes to reach 60wt% containing alcohol amount, leave standstill 8 hours, filter, filtrate recycling ethanol, to without alcohol taste, merges with the Cortex Ailanthi clear paste obtaining in step 1), be concentrated into the clear paste of relative density 1.05～1.10, dry, pulverize into fine powder, for subsequent use;
3) Olibanum adds the water of 6 times of weight, distills 5 hours, collects volatile oil;
4) Cortex Moutan distills with steam distillation, collects the distillate of 4 times of Cortex Moutan weight, places crystallize, filters, and the paeonol crystallization obtaining is separately put; Aqueous solution redistillation, collects the distillate of 2 times of Cortex Moutan weight, places crystallize, filters, and merges paeonol crystallization;
5) get the paeonol crystallization obtaining in Borneolum Syntheticum, step 4) with after a small amount of dissolve with ethanol, add the volatile oil of the Olibanum obtaining in step 3), by Borneolum Syntheticum, paeonol crystallization and Olibanum volatile oil: beta-schardinger dextrin-: the weight ratio that water is 1:8:80, stir and within 1 hour, carry out inclusion at 60 ℃, cold preservation is spent the night, and filters, and inclusion complex is 40 ℃ of cold drying, be ground into fine powder, for subsequent use;
6) by step 2) in the Cortex Ailanthi, the Radix Sophorae Flavescentis fine powder that obtain, the inclusion complex fine powder making with step 5) mixes, and adds adipic acid 220g and sodium bicarbonate 180g and mannitol 20g, mixes, and granulates, encapsulated, to obtain final product.
3. the method for the Chinese medicine composition effervescent granule of preparation treatment gynaecopathia, the crude drug of use is: Cortex Ailanthi 2000g, Radix Sophorae Flavescentis 1500g, Olibanum 1500g, Borneolum Syntheticum 50g, Cortex Moutan 1500g, it is characterized in that, comprise the steps:
1) Cortex Ailanthi decocts with water 2 times, adds altogether the water of 6 times of Cortex Ailanthi weight, decocts 1.5 hours at every turn, and collecting decoction, filters, and it is 1.05～1.10 Cortex Ailanthi clear paste that filtrate decompression is concentrated into relative density;
2) be soaked in water Radix Sophorae Flavescentis 1 hour, decocts with water the Radix Sophorae Flavescentis after soaking 2 times, adds altogether the water of 9 times of Radix Sophorae Flavescentis weight, each decoction 2 hours, collecting decoction, filters, filtrate decompression is concentrated into the Radix Sophorae Flavescentis clear paste of relative density 1.10～1.15, lets cool, and adds ethanol and makes to reach 65wt% containing alcohol amount, leave standstill 16 hours, filter, filtrate recycling ethanol is extremely without alcohol taste, merge with the Cortex Ailanthi clear paste obtaining in step 1), be concentrated into the clear paste of relative density 1.05～1.10, dry, be ground into fine powder, for subsequent use;
3) Olibanum adds the water of 8 times of weight, distills 7 hours, collects volatile oil;
4) Cortex Moutan distills with steam distillation, collects the distillate of 6 times of Cortex Moutan weight, places crystallize, filters, and the paeonol crystallization obtaining is separately put; Aqueous solution redistillation, collects the distillate of 3 times of Cortex Moutan weight, places crystallize, filters, and merges paeonol crystallization;
5) get the paeonol crystallization obtaining in Borneolum Syntheticum, step 4) with after a small amount of dissolve with ethanol, add the volatile oil of the Olibanum obtaining in step 3), by Borneolum Syntheticum, paeonol crystallization and Olibanum volatile oil: beta-schardinger dextrin-: the weight ratio that water is 1:8:80, stir and within 1 hour, carry out inclusion at 60 ℃, cold preservation is spent the night, and filters, and inclusion complex is 40 ℃ of cold drying, be ground into fine powder, for subsequent use;
6) by step 2) in the Cortex Ailanthi, the Radix Sophorae Flavescentis fine powder that obtain, the inclusion complex fine powder making with step 5) mixes, and adds adipic acid 240g and sodium bicarbonate 200g and mannitol 20g, mixes, and granulates, subpackage, to obtain final product.
4. the method for the Chinese medicine composition washing liquid of preparation treatment gynaecopathia, the crude drug of use is: Cortex Ailanthi 1750g, Radix Sophorae Flavescentis 1150g, Olibanum 1250g, Borneolum Syntheticum 40g, Cortex Moutan 1250g, it is characterized in that, comprise the steps:
1) add the decocting of 2 times of Cortex Ailanthi weight to boil 1 hour, filter decocting liquid, it is 1.05～1.10 Cortex Ailanthi clear paste that filtrate decompression is concentrated into relative density;
2) be soaked in water Radix Sophorae Flavescentis 0.5 hour, adds the decocting of 6 times of Radix Sophorae Flavescentis weight to boil 0.5 hour the Radix Sophorae Flavescentis after soaking, and filters decocting liquid, filtrate decompression is concentrated into the Radix Sophorae Flavescentis clear paste of relative density 1.10～1.15, lets cool, and adds ethanol and makes to reach 60wt% containing alcohol amount, leave standstill 8 hours, filter, filtrate recycling ethanol, to without alcohol taste, merges with the Cortex Ailanthi clear paste obtaining in step 1), be concentrated into the clear paste of relative density 1.05～1.10, dry, pulverize into fine powder, for subsequent use;
3) Olibanum adds the water of 6 times of weight, distills 5 hours, collects volatile oil;
4) Cortex Moutan distills with steam distillation, collects the distillate of 4 times of Cortex Moutan weight, places crystallize, filters, and the paeonol crystallization obtaining is separately put; Aqueous solution redistillation, collects the distillate of 2 times of Cortex Moutan weight, places crystallize, filters, and merges paeonol crystallization;
5) get the paeonol crystallization obtaining in Borneolum Syntheticum, step 4) with after a small amount of dissolve with ethanol, add the volatile oil of the Olibanum obtaining in step 3), with step 2) Cortex Ailanthi, the Radix Sophorae Flavescentis clear paste that make mix homogeneously, add again polyoxyethylene sorbitan monoleate 120g and sodium benzoate 60g, add water and be settled to 1000ml, to obtain final product.
5. the method for the Chinese medicine composition suppository of preparation treatment gynaecopathia, the crude drug of use is: Cortex Ailanthi 2250g, Radix Sophorae Flavescentis 1750g, Olibanum 1750g, Borneolum Syntheticum 60g, Cortex Moutan 1750g, it is characterized in that, comprise the steps:
1) Cortex Ailanthi decocts with water 3 times, adds altogether the water of 9 times of Cortex Ailanthi weight, decocts 2.5 hours at every turn, and collecting decoction, filters, and it is 1.05～1.10 Cortex Ailanthi clear paste that filtrate decompression is concentrated into relative density;
2) be soaked in water Radix Sophorae Flavescentis 1.5 hours, decocts with water the Radix Sophorae Flavescentis after soaking 3 times, adds altogether the water of 12 times of Radix Sophorae Flavescentis weight, each decoction 3 hours, collecting decoction, filters, filtrate decompression is concentrated into the Radix Sophorae Flavescentis clear paste of relative density 1.10～1.15, lets cool, and adds ethanol and makes to reach 70wt% containing alcohol amount, leave standstill 24 hours, filter, filtrate recycling ethanol is extremely without alcohol taste, merge with the Cortex Ailanthi clear paste obtaining in step 1), be concentrated into the clear paste of relative density 1.05～1.10, dry, be ground into fine powder, for subsequent use;
3) Olibanum adds the water of 10 times of weight, distills 9 hours, collects volatile oil;
4) Cortex Moutan distills with steam distillation, collects the distillate of 8 times of Cortex Moutan weight, places crystallize, filters, and the paeonol crystallization obtaining is separately put; Aqueous solution redistillation, collects the distillate of 4 times of Cortex Moutan weight, places crystallize, filters, and merges paeonol crystallization;
5) get the paeonol crystallization obtaining in Borneolum Syntheticum, step 4) with after a small amount of dissolve with ethanol, add the volatile oil of the Olibanum obtaining in step 3), by Borneolum Syntheticum, paeonol crystallization and Olibanum volatile oil: beta-schardinger dextrin-: the weight ratio that water is 1:8:80, stir and within 1 hour, carry out inclusion at 60 ℃, cold preservation is spent the night, and filters, and inclusion complex is 40 ℃ of cold drying, be ground into fine powder, for subsequent use;
6) by step 2) in the Cortex Ailanthi, the Radix Sophorae Flavescentis fine powder that obtain, the inclusion complex fine powder making with step 5) mixes, and adds the substrate being mixed with by 20g gelatin, 50g glycerol, 60g mannitol, makes suppository, to obtain final product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201010580133.2A CN102485247B (en) | 2010-12-06 | 2010-12-06 | Traditional Chinese medicine composition used for treating gynecologic diseases, and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201010580133.2A CN102485247B (en) | 2010-12-06 | 2010-12-06 | Traditional Chinese medicine composition used for treating gynecologic diseases, and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102485247A CN102485247A (en) | 2012-06-06 |
| CN102485247B true CN102485247B (en) | 2014-06-04 |
Family
ID=46150842
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201010580133.2A Active CN102485247B (en) | 2010-12-06 | 2010-12-06 | Traditional Chinese medicine composition used for treating gynecologic diseases, and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102485247B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103861120B (en) * | 2012-08-16 | 2015-12-09 | 湖北天圣康迪制药有限公司 | A kind of preparation method of enclose medicament |
| CN107267288A (en) * | 2017-06-17 | 2017-10-20 | 安徽仁之堂药业有限公司 | A kind of highly effective extraction method of Olibanum volatile oil |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1208074C (en) * | 2002-12-05 | 2005-06-29 | 株洲千金药业股份有限公司 | Chinese medicinal preparation for treating gynaecology disease of cervicitis |
| WO2009097512A1 (en) * | 2008-02-01 | 2009-08-06 | Innovative Drug Discovery Inc. | Herbal pharmaceutical compositions to treat inflammation and inflammation associated conditions and diseases |
| CN102085248B (en) * | 2009-12-07 | 2013-06-12 | 株洲千金药业股份有限公司 | Traditional Chinese medicinal composition for treating cervix diseases, method for preparing same and method for detecting same |
-
2010
- 2010-12-06 CN CN201010580133.2A patent/CN102485247B/en active Active
Non-Patent Citations (4)
| Title |
|---|
| 向大雄等.椿乳凝胶成型工艺研究.《中成药》.2006,第28卷(第8期),第1114-1116页，尤其是第1115页左栏第2-3段，右栏2.2.3处方及制备工艺. |
| 张杰等.椿乳凝胶中苦参、椿皮提取条件的研究.《中成药》.2006,第28卷(第6期),第893-895页，尤其是第894页右栏第2段. |
| 椿乳凝胶中苦参、椿皮提取条件的研究;张杰等;《中成药》;20060630;第28卷(第6期);第893-895页，尤其是第894页右栏第2段 * |
| 椿乳凝胶成型工艺研究;向大雄等;《中成药》;20060831;第28卷(第8期);第1114-1116页，尤其是第1115页左栏第2-3段，右栏2.2.3处方及制备工艺 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN102485247A (en) | 2012-06-06 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102091203B (en) | External traditional Chinese medicine preparation for treating chronic wounds and preparation method thereof | |
| CN104001034B (en) | A kind of Chinese herbal medicine unguentum treating empyrosis | |
| US10478463B2 (en) | External-use medicament for cleaning and care of the ovaries, vagina, and vulva | |
| CN106581439A (en) | Traditional Chinese medicine composition for treating wounds, diabetic feet and skin ulceration, and preparation method thereof | |
| CN101703651A (en) | Medicament for treating diabetic gangrene | |
| CN113616714A (en) | High-selenium anti-HPV (human papillomavirus) biological protein gel dressing and preparation method thereof | |
| CN102485247B (en) | Traditional Chinese medicine composition used for treating gynecologic diseases, and preparation method thereof | |
| CN103751532A (en) | Traditional Chinese medicine composition for treating gynecological inflammation and preparation method thereof | |
| CN100425238C (en) | Medicine for treating burns | |
| CN105560620A (en) | Trauma treatment traditional Chinese medicine preparation | |
| CN1857450A (en) | Chinese medicine prepn for treating dysmenorrhea | |
| CN1284593C (en) | Medicine for treating anaphylactoid purpura | |
| CN111991471A (en) | A topical Chinese medicinal preparation for treating knife wound, burn and scald, and its preparation method | |
| CN101904998A (en) | Special medicament for treating dermatophytosis and preparation method thereof | |
| CN111700989B (en) | Traditional Chinese medicine composition for dispelling wind, eliminating dampness and treating tinea pedis and preparation method thereof | |
| CN116832125B (en) | Traditional Chinese medicine composition, preparation method and application thereof | |
| CN1088811A (en) | Medicinal liquid for treating tinea | |
| CN110664934B (en) | Antibacterial and antipruritic traditional Chinese medicine composition and preparation method and application thereof | |
| CN102552362A (en) | Medicament for treating tinea | |
| CN105770204A (en) | Traditional Chinese medicine ointment for treating blister type dermatophytosis and preparing method thereof | |
| CN102125623A (en) | Chinese medicine composition for treating burns and scalds and application thereof | |
| CN103285177A (en) | Externally used paste for treating bedsore and furuncle | |
| CN108653396A (en) | The special irrigation of gynaecology containing fulvic acid | |
| CN117045717A (en) | External compound essential oil composition for treating eczema and preparation method thereof | |
| CN114129671A (en) | Externally applied traditional Chinese medicine for clearing toxin and relieving swelling of eyes and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant |