CN100425238C - Medicine for treating burns - Google Patents
Medicine for treating burns Download PDFInfo
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- CN100425238C CN100425238C CNB2006100481609A CN200610048160A CN100425238C CN 100425238 C CN100425238 C CN 100425238C CN B2006100481609 A CNB2006100481609 A CN B2006100481609A CN 200610048160 A CN200610048160 A CN 200610048160A CN 100425238 C CN100425238 C CN 100425238C
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Abstract
A medicine for treating burn with high curative effect and low cost is proportionally prepared from sulfonamides, borneol and VC.
Description
Technical field
The present invention relates to pharmaceutical product, specifically a kind of medicine that is used for the treatment of burn.
Technical background
Burn (comprising scald) is a kind of common sudden trauma, is all multifactor a kind of extremely complicated traumatic diseases that body causes that acts on such as physics, chemistry, radiation, and its sickness rate is the trend that rises year by year.Burn according to its order of severity can be divided into slightly, moderate, severe; According to the different levels of its local damage degree, with its three district's bands that are divided into similar concentric garden shape, promptly the center is the coagulation necrosis band, is the blood capillary blood stasis and stagnant zone on every side, and the periphery is congested band.The coagulation necrosis band is recoverability not, also claims the necrotic area band; Blood stasis and stagnant zone is the portion of tissue damage, belongs to " parabiosis " state; Congested band is the recoverability tissue; Blood stasis and stagnant zone and congested band change in organization mainly are that capillary permeability increases and expansion, slow blood flow, thus cause the blood capillary thromboembolism, cause local tissue hypoxia and cause influence the whole body system.Doctor trained in Western medicine generally adopts the dryness therapy when the treatment burn at present, promptly carries out dry exposed therapy at traumatic infection, allows wound surface keep dry, and breeds in a large number to suppress antibacterial; Stop traumatic infection simultaneously and with various antibiotic, impel the dry incrustation of wound surface; To the patient with severe symptoms, also need surgical operation to cut crust, skin-grafting.The problem that this method exists is: in simple dry the exposure, can cause the necrosis of human tissue cell; And the traumatic infection in the therapeutic process also is the problem that always allows the medical worker feel a delicacy about.Use penicillin as routine, can not reduce the early stage G of burn patient
-The bacterium cellulitis; And use 5～7 days persons of penicillin, can inspire drug-fast G quickly
-Bacillus infection.The application of medicine for external use such as silver sulfadiazine, mafenide, though traumatic infection is had significant control effect, its pair cell activity also has certain detrimental effect, particularly uses the silver sulfadiazine paste or the suspensoid of high concentration, and the suspicion that adds severely injured surface damage is arranged.Also having a kind of Therapeutic Method at present clinically is to adopt the external application occlusive dressing, promptly in wound surface coating Chinese medicinal ointment (as JINGWANHONG), antimicrobial ointment is wrapped up and be aided with the intravenous drip antibiotic.The shortcoming that this method exists is that Chinese medicinal ointment control infection ability can increase the weight of traumatic infection sometimes even also; And directly smearing of antimicrobial ointment can cause the bad or microcirculation disturbance of wound surface microcirculation, therefore can cause the generation of wound surface ulcer.Also there is a common problem in above method, be exactly the course of treatment long, the medical expense costliness.
Summary of the invention
Purpose of the present invention just provides a kind of good effect, fast, the low burn medicine powder of treatment cost of wound healing.
The object of the present invention is achieved like this:
Medicine provided by the present invention is made up of the component of following weight part ratio:
5～8 parts in sulfanilamide medicated powder, 1～2 part of Borneolum Syntheticum, 1～2 part of vitamin c powder.
In the sulfa drugss such as the optional usefulness of sulfanilamide medicated powder bacteresulf, silver sulfadiazine, sulfadiazine, mafenide, sulfaguanidine any one is wherein with the silver sulfadiazine best results.
Also can be added with in the prescription of medicine of the present invention: vitamin B
21～2 part.Also can be added with vitamin B simultaneously
11～2 part.Can further improve the curative effect of wound healing like this.
Borneolum Syntheticum in the pharmaceutical formulation of the present invention has the effect of analgesia, removing the necrotic tissue and promoting granulation; Sulfa drugs is mainly used in the inhibition bacterial metabolism, so it has good control action to traumatic infection; Vitamin C is collagen and the necessary composition of intercellular substance, and it can promote wound healing.Borneolum Syntheticum, ascorbic adding have effectively overcome the infringement that sulfa drugs pair cell activity is caused.Three's 5 usefulness both can reduce oozing out of wound fluid, can quicken the healing of wound tissue again, also can avoid traumatic infection simultaneously; And wound surface has further been protected in the effect of the removing oxygen-derived free radicals that vitamin C had again.Therefore three medicines, 5 usefulness have good synergism, and its clinical manifestation is: patient's course of disease shortens greatly, and the healing wound surface does not have cicatrization.
Medicine of the present invention specifically has following characteristics:
(1) medicine traumatic infection control of the present invention is effective.All uses medicine person of the present invention does not all find secondary infection; The patient of existing traumatic infection before being admitted to hospital, the lighter's medication 2～3 days, original infection can be effectively controlled in heavy person's medication 7～8 days.
(2) medicine of the present invention can be combined into one rapidly with the exudate of wound surface, and retardance and improve blood stasis and stagnant zone and the pathophysiological change of congested band, impels the wound surface skin to be recovered as soon as possible and reaches physiological reparation state.So it is fast that it has wound healing, the effect that no spot tissue forms.After using medicine of the present invention,, save a large amount of medical expenses thereby can be the patient even III degree fire victim does not need to carry out dermatoplastic treatment more yet.
(3) medicine medicine-feeding no pain of the present invention is easy to use and cheap for manufacturing cost.
The beneficial effect of medicine of the present invention has obtained checking by following clinical trial.
Clinical data
497 examples 1.1 burn, male's 346 examples (accounting for 69.6%) wherein, women's 151 examples (accounting for 30.4%); The oldest 76 years old, minimum 9 months; The course of disease is the longest 1 month, the shortest 15 minutes.
1.2 the causative factors of injury boiled water is scalded 338 examples (accounting for 68%), oils 124 examples (accounting for 24.9%) of burning, and Colophonium is scalded 6 examples (accounting for 2%), other reason 29 examples (accounting for 5.8%) of burning.
1.3 burn surface area (calculating): 1%～8%318 example (accounting for 64%), 11%～56% 179 example (accounting for 36%) according to Chinese rule of Nine.
1.4 burn degree (with three degree quartering estimation depth of burns): I degree 119 examples (accounting for 24%), shallow II degree 124 examples (accounting for 25%), dark II 144 examples (accounting for 29%), III degree 110 examples (accounting for 22%).
Therapeutic Method:
At first clean wound surface, again medicated powder of the present invention is approached spreading on wound surface, adopt exposure method, every day 1-2 time with distilled water or normal saline.
As before using medicated powder of the present invention, when wound surface severe infections has taken place, need auxiliary intravenous drip antibiotic medicine 3～5 days.
Therapeutic outcome
Cure 472 examples, account for 95%, produce effects 23 examples account for 4.6%, and invalid 2 examples account for 0.4%, and shallow II degree was cured 242 examples in following 2～3 days, dark 4～6 days cure rate 140 examples of II degree, and the III degree was cured 99 examples in 9～20 days.
The fire victim uses ointments burn medicine behind burn, and uses medicine person of the present invention in 6 hours, is no cicatrix after healing and produces.None example of III degree fire victim adopts dermatoplastic treatment.
Preparation method of the present invention:
According to formula ratio, take by weighing sulfonamides medicated powder, vitamins medicated powder, add Borneolum Syntheticum, grind well and get final product.
Usage and dosage: behind distilled water or normal saline cleaning wound surface, sprinkle medicine of the present invention gently on wound surface, the medicated powder consumption is advisable with very thin flap coverage.Generally once a day.Too much as transudate, when causing the wound surface medicine to soak, can increase a drug.
The specific embodiment
The preparation embodiment of preparation of the present invention:
Embodiment 1:
Take by weighing silver sulfadiazine medicated powder 8kg, vitamin C medicated powder 1kg, vitamin B
1Medicated powder 1kg, vitamin B
2Medicated powder 1kg, mixing adds Borneolum Syntheticum 1kg again, grinds well, and is distributed into bag.
Following examples preparation method is identical with embodiment 1, and just drug component and consumption are different, but all have effect of the present invention.
Above embodiment all can realize effect of the present invention, and it is to further specify of the present invention, but can not constitute any qualification to the present invention.
Claims (2)
1, a kind of burn medicine powder is characterized in that it is made up of the component of following weight part ratio:
5～8 parts in sulfanilamide medicated powder, 1～2 part of Borneolum Syntheticum, 1～2 part of vitamin c powder.
2, burn medicine according to claim 1 is characterized in that said sulfanilamide medicated powder is any one in bacteresulf, silver sulfadiazine, sulfadiazine, mafenide, the sulfaguanidine.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2006100481609A CN100425238C (en) | 2006-08-18 | 2006-08-18 | Medicine for treating burns |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2006100481609A CN100425238C (en) | 2006-08-18 | 2006-08-18 | Medicine for treating burns |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1911231A CN1911231A (en) | 2007-02-14 |
| CN100425238C true CN100425238C (en) | 2008-10-15 |
Family
ID=37720395
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB2006100481609A Expired - Fee Related CN100425238C (en) | 2006-08-18 | 2006-08-18 | Medicine for treating burns |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN100425238C (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104324070A (en) * | 2014-11-03 | 2015-02-04 | 黄华良 | External and orally-taken drug for treating ulcer disease and preparation method of external and orally-taken drug |
| CN108042839A (en) * | 2017-12-19 | 2018-05-18 | 湖北工程学院 | A kind of chitosan complexes bandage and preparation method thereof |
| CN111920824A (en) * | 2020-09-11 | 2020-11-13 | 余朝权 | A Chinese medicinal composition for treating wound |
| CN114796288A (en) * | 2022-04-25 | 2022-07-29 | 吴彩芳 | External medicine for burns and scalds and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1181264A (en) * | 1997-11-07 | 1998-05-13 | 伍先令 | Zaohuang paste and treating burns and its prepn. |
| CN1270812A (en) * | 2000-03-30 | 2000-10-25 | 蔡胜利 | Burn and scald treating medicine and its preparation |
| CN1306833A (en) * | 2000-01-21 | 2001-08-08 | 卫和平 | External-use extract for treating burns and scalds fast and its preparation |
-
2006
- 2006-08-18 CN CNB2006100481609A patent/CN100425238C/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1181264A (en) * | 1997-11-07 | 1998-05-13 | 伍先令 | Zaohuang paste and treating burns and its prepn. |
| CN1306833A (en) * | 2000-01-21 | 2001-08-08 | 卫和平 | External-use extract for treating burns and scalds fast and its preparation |
| CN1270812A (en) * | 2000-03-30 | 2000-10-25 | 蔡胜利 | Burn and scald treating medicine and its preparation |
Non-Patent Citations (4)
| Title |
|---|
| 烧伤与维生素. 孙珍等.上海医药，第11期. 1994 |
| 烧伤与维生素. 孙珍等.上海医药，第11期. 1994 * |
| 烧伤创面修复后期皮肤过敏二例. 李辉等.中华烧伤杂志，第20卷第6期. 2004 |
| 烧伤创面修复后期皮肤过敏二例. 李辉等.中华烧伤杂志，第20卷第6期. 2004 * |
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| Publication number | Publication date |
|---|---|
| CN1911231A (en) | 2007-02-14 |
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| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C17 | Cessation of patent right | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20081015 Termination date: 20130818 |