CN1186068C - Externally applied Chinese medicine with functions of diminishing inflammation, promoting granulation, stopping itch and stopping pain and its prepn process - Google Patents
Externally applied Chinese medicine with functions of diminishing inflammation, promoting granulation, stopping itch and stopping pain and its prepn process Download PDFInfo
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- CN1186068C CN1186068C CNB021446970A CN02144697A CN1186068C CN 1186068 C CN1186068 C CN 1186068C CN B021446970 A CNB021446970 A CN B021446970A CN 02144697 A CN02144697 A CN 02144697A CN 1186068 C CN1186068 C CN 1186068C
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Abstract
The present invention relates to an externally applied Chinese medicine with the functions for diminishing inflammation, promoting skin regeneration, stopping itching and stopping pain, and a preparation method thereof. The medicine is prepared from five Chinese herbal medicines comprising alkanna tinctoria, clam shell, acacia catechu, gypsum, borneo camphor, etc., and can be widely applied to gynecology, surgery, dermatology, etc. for treating bacterial inflammation: skin inflammation and ulcerous diseases, such as various kinds of burn and scald, contused and rubbing wounds, bedsore, pruritus vulvae, ulcers, hemorrhoids, anal fissures, anal fistula, etc., and nonbacterial inflammation: skin diseases, such as dermatitis, tinea, pruritus, acne, a bottle nose, herpes zoster, etc. The present invention has the advantages of convenient use, loose requirements for disinfecting and cleaning wounds of medicine applied regions, medicine change without removing scab, pain relief for patients, obvious therapeutic effect and short course of treatment. Simultaneously, the present invention has the effects for relieving inflammation, regenerating skin and stopping itching and pain, and the effect for stopping itching and pain is obvious. The present invention has the characteristics of reduction of patients' reinfection and recurrence of wounds, no toxic or side effect, no medicinal resistance, unique formula, wide ranges and easy obtaining of medicinal resources, simple preparation technique, low cost, etc. The total effective rate is 98%. After the externally applied Chinese medicine is implemented or generalized, great economical and social benefits can be generated to benefit mankind.
Description
Technical field
The present invention relates to the Chinese herbal medicine be raw material have external Chinese patent medicine of the antipruritic analgesic effect of dephlogistication and promoting nuscle growth and preparation method thereof.
Background technology
Bacillary, non-bacteria inflammation due to a variety of causes, ulcer skin diseases such as (frustrating contusion, decubital ulcer, dermatitis) as various burn and scald, skin, sickness rate is higher, it is one of commonly encountered diseases frequently-occurring disease of surgery, department of dermatologry, gynecological, treat complication such as untimely frequent secondary systemic infection, shock, septicemia, even cause death.The specific medicament for the treatment of these diseases seldom, Western medicine is used hormone, anti-microbial type medicine more, curative effect is very dissatisfied, only can antibiotic, infection, no granulation promoting itching-relieving action, and prolonged application easily develops immunity to drugs and untoward reaction such as allergy.Some are also arranged is the medicine for external use of raw material with the Chinese herbal medicine, exist in various degree many with the flavour of a drug number, effect is single, curative effect is not high, the course of treatment length, complicated process of preparation, the high deficiency of cost.
Summary of the invention
The purpose of this invention is to provide and a kind ofly fill a prescription simple uniquely, evident in efficacy, applied range, have the external Chinese patent medicine of antiinflammatory, granulation promoting, antipruritic, analgesic effect simultaneously.
Chinese patent medicine of the present invention is made up of five tastes Chinese herbal medicine such as Radix Arnebiae (Radix Lithospermi), Concha Meretricis Seu Cyclinae, catechu, Gypsum Fibrosum, Borneolum Syntheticums.
Radix Arnebiae (Radix Lithospermi) is the root of Boraginaceae herbaceos perennial Radix Arnebiae (Radix Lithospermi) Lithospermum erythrorhizon Sieb.etZucc. and lithospermum euchromum Royle Arnebia euchroma (Royle) Johnst. or arnebia guttata Bunge Arnebia guttataBunge..Abnormal smells from the patient bitter cold, color purple are gone into blood, so the heat of cleaning blood system, ancients control the accumulation of heat of internal organs, and the then special treatment of smallpox infections of descendant is treated macule, all positive purport of heat clearing and blood cooling and hold concurrently.All outer infections blood system excess-heat persons of man, all available it.And the excess-fire disease of all bleeding due to blood-heaies, and the strong domination of pathogen person of gas of dysentery, internal hemorrhoid with bleeding, hematuria, pouring blood are all in the example of application.Modern pharmacological research shows that this medical instrument has resisting pathogenic microbes, antiinflammatory action, has obvious inhibitory action to exudative inflammation.
Concha Meretricis Seu Cyclinae is the shell of Veneridae animal Conch Meretricis seu Cyclinae Meretrix meretrix Linnaeus or Concha Meretricis Seu Cyclinae Cyclina sinensisGmelin.By the Concha Meretricis Seu Cyclinae powder that calcined CONCHA MERETRICIS SEU CYCLINAE is made, be applied to the part and can control acne rosacea, external has the merit of the convergence open sore part.Be used for diseases such as burn and scald, eczema.
Catechu is the peeling branch of pulse family deciduous tree plant catechu Acacia catechu (L.) Willd., dried soft extracts.Bitter, adstringency is cool, and good removing dampness, promoting tissue regeneration and ulcer healing effect are arranged, and festers so control all skin ulcers, flowing water is not held back.Property is puckery, and the merit of astringing to arrest bleeding is arranged.Inside and outside hemorrhage disease is planted by available Zhiduo County.
Gypsum Fibrosum is a kind of Ore, promptly contains water of crystallization calcium sulfate (CaSO
42H
2O).Gypsum Fibrosum Preparatum has the removing dampness granulation promoting, holds back skin ulcer hemostatic effect.Diseases such as treatment of ulcer is not held back, traumatic hemorrhage.Spreading can reduce secretions and ooze out on wound surface equably, promotes incrustation, protects from infection, and quickens wound healing.
Borneolum Syntheticum is the processed goods that the Dipterocarpaceae aiphyllium is worth thing Borneolum Syntheticum Drgobalanops aromatica Gaertn.f. resin, or the trunk of Borneolum Syntheticum is through distilling the crystallization of cooling off and getting, title " borneol ", also title " borneol ".Split to cut through processing by the sublimate of Compositae herbaceos perennial Herba Blumeae Balsamiferae (Da Ai) Blumea balsamifera DC. leaf and form, claim " Blumeae preparatum Tabellae ".Now many with Oleum Terebinthinae, Camphora etc., synthetic through chemical method, claim " BORNEOLUM SYNTHETICUM ".Cool in nature, have heat-clearing and toxic substances removing, promoting tissue regeneration and ulcer healing effect.We treat inside and outside hemorrhoid with its heat clearing away (detoxifcation) detumescence, promoting tissue regeneration and ulcer healing, antalgesic-antipruritic.Borneolum Syntheticum gas perfume (or spice) does not have toward not reaching, and can draw interior-heat and sore is gone out.
All medicines share, and tie in, and can reach clearing away heat-damp and promoting diuresis, promoting tissue regeneration and ulcer healing, pain relieving, antipruritic effect.
Wherein the shared parts by weight of each component are as follows:
Radix Arnebiae (Radix Lithospermi) 5-15 Concha Meretricis Seu Cyclinae 35-110 catechu 20-50
Gypsum Fibrosum 15-45 Borneolum Syntheticum 15-45
According to adding substrate or the difference of adjuvant etc., adopt the common process of Chinese medicine preparation, Chinese patent medicine of the present invention can be made into different dosage forms such as powder, unguentum, suppository, aerosol, membrane, cream, ear drop, nasal drop.
Another object of the present invention provides a kind of preparation method with external Chinese patent medicine of the antipruritic analgesic effect of dephlogistication and promoting nuscle growth.
The preparation method of the Chinese herbal medicine of above-mentioned each component being made Chinese patent medicine of the present invention is:
1, get clean Concha Meretricis Seu Cyclinae, Gypsum Fibrosum respectively after the calcine cooling, processing powder is broken into 120 order fine powders;
2, get clean catechu, Radix Arnebiae (Radix Lithospermi), Borneolum Syntheticum respectively after the drying, processing powder is broken into 120 order fine powders;
3, above-mentioned whole powder components are mixed in proportion, after the ripening sterilization treatment, get the powder medicine of Chinese patent medicine of the present invention.
Get substrate commonly used, propellant or adjuvant in 3 gained protogenic medicinal powder and the Chinese medicine preparation, adopt the common process and the preparation method of Chinese medicine preparation, Chinese patent medicine of the present invention also can be made different dosage forms such as unguentum, suppository, aerosol, membrane, cream, ear drop, nasal drop easily.
Therapeutic effect for the medical ointment that improves Chinese patent medicine of the present invention, can earlier Radix Arnebiae (Radix Lithospermi) be put into vegetable oil soaks, leaching fluid gets Oleum Radix Arnebiae (Oleum Radix Lithospermi), add Concha Meretricis Seu Cyclinae, Gypsum Fibrosum, catechu, Borneolum Syntheticum medicated powder and substrate (as vaseline, plant wet goods) then, grinding is mixed, and gets the medical ointment of Chinese patent medicine of the present invention.According to the difference of substrate, technology is determined drug treating and is added method in the substrate and the method for making of unguentum routinely.
Chinese patent medicine of the present invention has following characteristics:
1, has wide range of applications.Chinese patent medicine of the present invention can be used for treating bacterial inflammation: various skin burns, frustrate scytitis, ulcer diseases such as contusion, decubital ulcer, pruritus vulvae, ulcer, hemorrhoid, anal fissure, anal fistula; Non-bacteria inflammation: dermatosiss such as erythra, dermatitis, tinea, pruritus, acne, acne rosacea, herpes zoster.Can be widely used in the treatment of diseases such as gynecological, surgery, department of dermatologry.
2, treatment is easy to use.Only need get final product in affected part surface medication, especially not strict to agents area sterilization debridement requirement, needn't go crust when changing dressings, thereby alleviate the short formation that reaches new wound surface of pain greatly because of going crust to bring to the patient.
3, evident in efficacy, short treating period.Chinese patent medicine of the present invention is except that having significant antiinflammatory action, also have very significantly granulation promoting, antipruritic, analgesic effect, the union of wounded skin time is shifted to an earlier date greatly, and reduce patient and scratch the infection and the chance of wound more again that is brought in the wound surface granulation tissue generation phase because of itching.
4, stable curative effect has no side effect.Pure Chinese medicine is made, and stable performance has no side effect, and is difficult for developing immunity to drugs and untoward reaction such as allergy.
5, prescription is unique, and the medicine source is extensive, is easy to get, and preparation technology is simple, and cost is low, and the patient is acceptant, will produce than great society benefit and economic benefit after implementing to promote, and promotes the well-being of mankind.
The specific embodiment
Below in conjunction with embodiment the present invention is further described.
Embodiment 1-3 is the powder " five tastes antiinflammatory granulation promoting is itched and loose bitterly " of Chinese patent medicine of the present invention; Embodiment 4-8 is the unguentum " five tastes antiinflammatory granulation promoting itch pain cream " of Chinese patent medicine of the present invention.
The proportioning of each component is as shown in table 1 among each embodiment.(table 1 is attached)
The preparation method of embodiment 1-3 is as follows:
After calcine cooled off respectively with Concha Meretricis Seu Cyclinae, Gypsum Fibrosum, processing powder was broken into 120 order fine powders; The dry respectively post-treatment of catechu, Radix Arnebiae (Radix Lithospermi), Borneolum Syntheticum is ground into 120 order fine powders; Above-mentioned medicated powder is mixed in proportion, after the ripening sterilization treatment, get " five tastes antiinflammatory granulation promoting is itched and loose bitterly ".
The preparation method of embodiment 4-8 is as follows:
Earlier Radix Arnebiae (Radix Lithospermi) is put into vegetable oil and soak, it is standby that leaching fluid gets Oleum Radix Arnebiae (Oleum Radix Lithospermi); With calcined CONCHA MERETRICIS SEU CYCLINAE, Gypsum Fibrosum Preparatum, catechu respectively processing powder be broken into 120 order fine powders; In proportion Oleum Radix Arnebiae (Oleum Radix Lithospermi) and calcined CONCHA MERETRICIS SEU CYCLINAE, Gypsum Fibrosum Preparatum, catechu medicated powder are ground be mixed after, add vaseline that water-bath dissolves and grind and be mixed, be cooled to and add Borneolum Syntheticum medicated powder about 30 ℃ again and continue to grind and be mixed, " five tastes antiinflammatory granulation promoting itch pain cream ".
For verifying the therapeutic effect of Chinese patent medicine of the present invention, choose " five tastes dephlogistication and promoting nuscle growth itch pain cream " of content of dispersion 12.5%, 6.25%, carry out the long-term toxicity of animal, acute toxicology, pharmacodynamics and clinical efficacy test through Jilin Beihua University medical college.Long-term toxicological test shows, all no abnormal change such as medication rats eating amount, body weight, outward appearance sign and behavioral activity, feces etc. is compared there was no significant difference, the no phenomena of mortality with matched group.A no abnormal change of index such as routine blood test, liver, renal function, histopathologic examination proves that Chinese patent medicine of the present invention does not have the skin absorbs toxic action.Acute toxinology experiment, mixed liquor with " five tastes dephlogistication and promoting nuscle growth is itched and loose bitterly " is given mice lavage, maximal dose 0.4ml/20g, oral twice of every day (being 10g/kg/ day), observe after 24,48,72 hours and 7,30 days continuously, there is no dead mouse and other uncomfortable performance is arranged, its median lethal dose(LD 50) is greater than 10g/kg (P＜0.01).Show Chinese patent medicine of the present invention oral be safe, external preparation for skin is safer.Pharmacodynamics test divides two groups rat skin is scalded the effect of face promoting healing to observe with " five tastes dephlogistication and promoting nuscle growth itch pain cream " of content of dispersion 12.5%, 6.25%, and compares group with vaseline, silver sulfadiazine.Rat skin is scalded to heal after 15 days and be the results are shown in Table 2.(table 2 is attached) pathological examination sees that vaseline group rat skin scald wound has infection, surface that pus is arranged, and shows that vaseline does not have the short regeneration of infection.Other three groups of rat skin wound surface do not have infection and extract, make epithelium regeneration, but silver sulfadiazine group epithelium regeneration are limited.Two groups of epithelium regenerations with Chinese patent medicine administration of the present invention are complete, have remarkable infection and short wound healing regeneration, and scar tissue generates and reduces, and proves that Chinese patent medicine antiinflammatory of the present invention, promoting muscle growth functions obviously are better than matched group.
With " five tastes dephlogistication and promoting nuscle growth itch pain cream " of content of dispersion 6.25%, 2%, through the clinical observation of 188 routine systems, the his-and-hers watches skin lesion is hindered the patient, and one day wound surface of coating can be fully recovered; Two degree also can be fully recovered in skin injury coating 1-2 week; To antiinflammatory, promoting healing effects such as large tracts of land burn and scald, decubital ulcers, curative effect all is better than with chloromycetin, MEIBAO Scald Ointment matched groups such as (productions of Shantou Special Economic Zone, Guangdong Province MEIBAO pharmaceutical factory); In addition to diabetes, tumor patient with significant curative effect is also arranged because of skin infection of weak difficult healing etc.By statistics, that obtains significant curative effect accounts for 52%, substantially effectively accounts for 46%, and invalid accounts for 2%, and total effective rate reaches 98%.
Table 1
| Embodiment number | Nomenclature of drug | Radix Arnebiae (Radix Lithospermi) (kg) | Concha Meretricis Seu Cyclinae (kg) | Catechu (kg) | Gypsum Fibrosum (kg) | Borneolum Syntheticum (kg) | Vaseline (kg) | |
| 1 | Five tastes dephlogistication and promoting nuscle growth is itched and is loose bitterly | 50 | 350 | 200 | 150 | 150 | ||
| 2 | 90 | 800 | 400 | 250 | 300 | |||
| 3 | 150 | 1100 | 500 | 450 | 450 | |||
| 4 | Five tastes dephlogistication and promoting nuscle growth itch the pain cream | Content of dispersion (down together) 25% | 5 | 35 | 20 | 15 | 15 | 270 |
| 5 | 12.5％ | 9 | 80 | 40 | 25 | 30 | 1288 | |
| 6 | 6.25％ | 15 | 110 | 50 | 45 | 45 | 3975 | |
| 7 | 3.125％ | 8 | 100 | 30 | 40 | 20 | 6138 | |
| 8 | 2％ | 10 | 60 | 45 | 20 | 40 | 8400 | |
Table 2
| Group | Medicine | n | Scalding area (cm 2) | P | Healing (%) | |
| X ± SD before the medication | X ± SD after the medication | |||||
| 1 | Vaseline | 10 | 7.15±1.6 | 7.9±0.8 | 10.5 | |
| 2 | Silver sulfadiazine | 10 | 6.7±1.4 | 1.3±1.1 | ＜0.01 | 80.1 |
| 3 | 12.5% ointment of the present invention | 10 | 6.9±1.1 | 1.1±1.2 | ＜0.01 | 84.1 |
| 4 | 6.25% ointment of the present invention | 10 | 7.0±1.3 | 1.1±1.1 | ＜0.01 | 85.0 |
Claims (5)
1, a kind of external Chinese patent medicine with the antipruritic analgesic effect of dephlogistication and promoting nuscle growth is characterized in that being made by following raw medicaments in portion by weight:
Radix Arnebiae (Radix Lithospermi) 5-15 Concha Meretricis Seu Cyclinae 35-110 catechu 20-50
Gypsum Fibrosum 15-45 Borneolum Syntheticum 15-45.
2, according to the external Chinese patent medicine with the antipruritic analgesic effect of dephlogistication and promoting nuscle growth of claim 1, the dosage form that it is characterized in that said Chinese patent medicine is powder, unguentum, suppository, aerosol, membrane, cream, ear drop, nasal drop.
3, as the preparation method of the external Chinese patent medicine with the antipruritic analgesic effect of dephlogistication and promoting nuscle growth of claim 1 or 2, it is characterized in that preparation method is:
(1) get clean Concha Meretricis Seu Cyclinae, Gypsum Fibrosum respectively after the calcine cooling, processing powder is broken into 120 order fine powders;
(2) get clean catechu, Radix Arnebiae (Radix Lithospermi), Borneolum Syntheticum respectively after the drying, processing powder is broken into 120 order fine powders;
(3) above-mentioned whole powder components are mixed in proportion, after the ripening sterilization treatment, get powder.
4, as the preparation method of the external Chinese patent medicine with the antipruritic analgesic effect of dephlogistication and promoting nuscle growth of claim 1 or 2, it is characterized in that earlier Radix Arnebiae (Radix Lithospermi) being put into vegetable oil soaks, leaching fluid gets Oleum Radix Arnebiae (Oleum Radix Lithospermi), adds Concha Meretricis Seu Cyclinae, Gypsum Fibrosum, catechu, Borneolum Syntheticum medicated powder and substrate then, grinding is mixed, and gets unguentum.
5, according to the preparation method of the external Chinese patent medicine with the antipruritic analgesic effect of dephlogistication and promoting nuscle growth of claim 4, it is characterized in that said substrate is vaseline, vegetable oil.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB021446970A CN1186068C (en) | 2002-12-03 | 2002-12-03 | Externally applied Chinese medicine with functions of diminishing inflammation, promoting granulation, stopping itch and stopping pain and its prepn process |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB021446970A CN1186068C (en) | 2002-12-03 | 2002-12-03 | Externally applied Chinese medicine with functions of diminishing inflammation, promoting granulation, stopping itch and stopping pain and its prepn process |
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| Publication Number | Publication Date |
|---|---|
| CN1416859A CN1416859A (en) | 2003-05-14 |
| CN1186068C true CN1186068C (en) | 2005-01-26 |
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| CNB021446970A Expired - Fee Related CN1186068C (en) | 2002-12-03 | 2002-12-03 | Externally applied Chinese medicine with functions of diminishing inflammation, promoting granulation, stopping itch and stopping pain and its prepn process |
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Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102188472B (en) * | 2011-05-12 | 2012-11-14 | 江苏华生安颐生物科技有限公司 | Traditional Chinese medicine application for diminishing inflammation and promoting granules and preparation method thereof |
| CN103479788B (en) * | 2013-09-25 | 2015-01-14 | 刘沛源 | Traditional Chinese medicine composition for treating macula and preparation method thereof |
| CN106474172A (en) * | 2016-11-29 | 2017-03-08 | 佛山健翔医院有限公司 | A kind of reducing swelling and alleviating pain ointment and preparation method thereof |
| CN109512907A (en) * | 2018-12-18 | 2019-03-26 | 唐吉悦 | A kind of external drug for treating burn |
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