CN1072499C

CN1072499C - External-use medicine for curing various chronic ulcers

Info

Publication number: CN1072499C
Application number: CN98112800A
Authority: CN
Inventors: 毛和平
Original assignee: Individual
Current assignee: Individual
Priority date: 1998-12-28
Filing date: 1998-12-28
Publication date: 2001-10-10
Anticipated expiration: 2018-12-28
Also published as: CN1224617A

Abstract

The present invention relates to an external remedy for treating different chronic ulcer, which is prepared from 20 to 30% of ciprofloxacin hydrochloride, 10 to 20% of red phosphorus, 5 to 10% of notoginseng, 10 to 20% of camphol, 5 to 10% of Crinis Carbonisatus and 5 to 10% of pearl. The external remedy which can quickly heal cankered surfaces has favourable effects on arresting bleeding, alleviating pain, resisting bacteria and relieving inflammation, and also has strong capability of removing putrefaction and promoting tissue regeneration. Therefore, the external remedy is suitable for various wound surfaces of chronic ulcer and various open and fresh wound surfaces.

Description

A kind of medicine for external use for the treatment of the body surface chronic ulcer

The present invention relates to a kind of medicine for external use that the body surface chronic ulcer is played treatment healing effect.

Chronic surface ulcers is as a kind of commonly encountered diseases, the pale edema of its granulation tissue, substrate forms the feltwork plate, and is hard, lack flexibility, influence the blood supply of top layer granulation tissue, and the general drug resistance of wound surface antibacterial, wound surface ulceration repeatedly caused, prolonged changing dressings is difficult to healing, the course of disease is long, and patient is painful big, and it is thorny that the clinician quite feels.The external used medicine of the treatment ulcer that the development curative effect is outstanding is the problem that medical circle is paid attention to always.At present, the medicine for external use of employed clinically treatment ulcer in body surface, all not good enough as curative effects such as " moist expose burn ointment ", " eastern Bulbus Fritillariae Thunbergii multiple agent ", almost there is not effective medicine for external use of special-purpose treatment ulcer.

The object of the present invention is to provide a kind of pain relieving rapidly, anti-inflammation and putrefaction-removing granulation-promoting effect treat the bonded medicine for external use in Chinese and Western of body surface chronic ulcer significantly---hinder the spirit of bursting.Through how tame hospital clinical evidence, the present invention all obtains significant curative effect at aspects such as treatment chronic surface ulcers, burn scar ulcer, radiation ulcer, decubital ulcer, fistula holes.Adopt random packet, positive drug contrast scheme, " hindering the spirit of bursting " treatment chronic surface ulcers clinical efficacy and safety are carried out systematic observation.The contrast medicine is selected " moist expose burn ointment " and " Bfgf-ESSEX ".Observe 293 examples altogether, wherein 147 examples, one group of (moist expose burn ointment group) 88 example of contrast are organized in treatment, contrast two groups of (Bfgf-ESSEX group) 58 examples.The result shows that " hindering the spirit of bursting " treatment chronic surface ulcers obvious effective rate is 77.6%, and total effective rate is 98.6%, is better than " moist expose burn ointment " (P＜0.01) and " Bfgf-ESSEX ".Do not see obvious adverse reaction in the clinical observation, indexs such as blood, routine urinalysis and liver, renal function are also had no adverse effects.

The present invention by in multiple, the Western medicine material mixes and to develop, the dark gray powder shape, fragrant odour, nontoxic, have no side effect, do not have irritated reaction.

The object of the present invention is achieved like this.

Prescription is: (by weight)

Combine for 1 part by 0.5 part of ciprofloxacin, 1 part of Borneolum Syntheticum, 1 part in red phosphorus, 1 part of Crinis Carbonisatus, 1 part of Radix Notoginseng, Margarita.

The pharmacological property of each composition: ciprofloxacin: molecular formula: [G ₁₇H ₁₈FN ₃OHCLH ₂O=385.82]

Character: white or faint yellow, odorless, bitter in the mouth.

Pharmacological action: have broad-spectrum antibacterial action, escherichia coli, klebsiella and other enterobacteria kind negative bacillus had stronger antibacterial activity, antibacterial action to bacillus pyocyaneus, staphylococcus aureus and Diplococcus pneumoniae, first type Streptococcus hemolyticus, beta hemolysis streptococcus etc. is better than norfloxacin, pefloxacin mesilate, but this product is to the too late penicillins antibiotics of the antibacterial action of Streptococcus.This product antibacterial action mechanism is for suppressing the DNA of bacteria helicase, and antibacterial action is an antibacterial type.This product and other antibiotic do not have cross resistance, and be still responsive to this product to beta-lactam, fluorine-based glucoside, sulfonamides fastbacteria.Borneolum Syntheticum: the source: a kind of is that synthetic Borneolum Syntheticum Dryobdamops aromatica Gaerth.F. is a raw material with Oleum Terebinthinae, Herba Blumeae Balsamiferae oxalic acid, synthetic with boric anhydride catalysis; Another kind is that the blade that belongs to big maple Chinese mugwort with feverfew Blumeabalsamifera DC. is a raw material, extracts through distillation processing to form, and has another name called Blumeae preparatum Tabellae.

Main component: contain volatile oil, main constituent is left-handed Borneolum Syntheticum, contains a small amount of eucalyptole again, left-handed Camphora.

Pharmacological action: causing resuscitation with aromatic drugs, heat radiation pain relieving.Act as: I, stimulating central nervous system system.2, antibiotic.Its tincture of in vitro tests has bacteriostasis to staphylococcus aureus, escherichia coli, hog cholera bacterium, and its powder and blue or green agent have the full effect that presses down to Pilus Caprae seu Ovis sample sporidiole bacteria, trichophyton etc.

Nature and flavor: hot, bitter, be slightly cold.

Function: heat clearing away is sensible, reducing swelling and alleviating pain.Red phosphorus (P): the rufous powder, nontoxic, industrial as duration and degree of heating raw material and phosphorus compound, also use for organic synthesis.Property suffering, cold, puckery.Effect: astringing to arrest bleeding, anti-inflammatory analgesic, putrefaction-removing granulation-promoting.Crinis Carbonisatus: the i.e. charcoal that Crinis Carbonisatus processing calcination forms, property suffering, tepor.Effect: repercussive, hemostasis, analgesia mainly contain eukerating, moisture, ash, fat, ammonia, sulfur.Radix Notoginseng: source: be the dry root of Araliaceae herbaceos perennial Radix Notoginseng.

Main component: contain arasaponin first (C ₃₀H ₅₃O ₁₆), arasaponin second (C ₂₃H ₃₈O ₁₆) and flavonoid glycoside.

Pharmacological action: hemostasis, blood stasis dispelling, detumescence, pain relieving.Its pharmacology is: 1, hemostasis.Radix Notoginseng warm macerating liquid can shorten the rabbit clotting time, and the vasoconstrictive effect is arranged.2, antiinflammatory.The pseudo-ginseng water decocting liquid has obvious inhibitory action to rat experiment arthritis.3, increase coronary flow.The Radix Notoginseng flavonoid glycoside can obviously increase the heart coronary artery flow, and myocardial oxygen consumption reduces simultaneously.The Radix Notoginseng decocting seemingly has the effect of glucocorticoid sample again.

Nature and flavor: sweet, little hardship, temperature.

Function: hemostasia and dissipation blood stasis, detumescence hemostasis.Margarita: sweet, salty, cold.Go into the heart, Liver Channel, effect: conjunctival congestion and swelling pain, laryngopharynx swelling and pain, aphtha of the mouth and tongue, skin infection are burst for a long time and are not held back, detoxify, promoting tissue regeneration and ulcer healing.Compound method:

Ciprofloxacin is got powder, all the other five kinds of equal pulverizes of raw material are also crossed 120 mesh sieves, in proportion after the weighing, earlier that Crinis Carbonisatus, red phosphorus, Borneolum Syntheticum, four kinds of powder mixes of Margarita is even, sterilize through high-temperature sterilization, again with Radix Notoginseng through ozonization, it is even to add the ciprofloxacin powder mixes at last, gets final product packaging applications.

The present invention compares with the medicine for external use of the various ulcer of existing treatment, has following advantage:

One, good analgesic effect: the present invention has circulation of qi promoting, invigorates blood circulation, the function of heat clearing away repercussive, and the chronic ulcer patient of various pain after the debridement, only needs medicated powder is sprinkled into wound surface, and pain is controlled fully within three minutes.

Two, the anti-inflammation effect is remarkable, and the present invention has the high-efficiency broad spectrum antibacterial action, and small size ulcer infected patient does not need oral or the injection antibacterials, and list can be fully recovered with this product.

Three, the putrefaction-removing granulation-promoting ability is outstanding, shows the few wound surface of shallow secretions, can grow fresh granulation tissue in general medication 3-4 days,, purulence slough dark to wound surface can make slough liquefy naturally more at most, non-invasi is got rid of, and does not need to cut with the cutter pincers to cut patient's no pain.

Four, has the peripheral epithelial growth effect of tangible promotion.General ulcer surface obviously dwindled about 5 days.

Five, after patient's medication, local excitation is little, and toxic and side effects and anaphylaxis are seen in the end, and be easy to use, is local topical medicine safely and effectively.

Embodiment 1:

Get ciprofloxacin powder 300 grams, Borneolum Syntheticum 200 grams, red phosphorus 150 grams, Crinis Carbonisatus 300 grams, Radix Notoginseng 150 grams, Margarita 200 grams, Borneolum Syntheticum, red phosphorus, Crinis Carbonisatus, Radix Notoginseng, five kinds of equal pulverizes of raw material of Margarita are also crossed 120 mesh sieves, in proportion after the weighing, earlier that Crinis Carbonisatus, red phosphorus, Borneolum Syntheticum, four kinds of powder mixes of Margarita is even, sterilize through high-temperature sterilization, again with Radix Notoginseng through ozonization, add the mixed packaging applications that gets final product of ciprofloxacin powder at last again.

Embodiment 2:

Get ciprofloxacin 250 grams, Borneolum Syntheticum 300 grams, red phosphorus 200 grams, Crinis Carbonisatus 400 grams, Radix Notoginseng 200 grams, Margarita 100 grams, processing technique is identical with embodiment 1.

Claims

1, a kind of medicine for external use that is used for the treatment of the body surface chronic ulcer, it is characterized in that forming by ciprofloxacin, red phosphorus, Radix Notoginseng, Borneolum Syntheticum, Crinis Carbonisatus, Margarita, the parts by weight of each composition are: ciprofloxacin 25-30, Borneolum Syntheticum 20-30, red phosphorus 15-20, Crinis Carbonisatus 30-40, Radix Notoginseng 15-20, Margarita 10-20.