CN105748583A - An encapsulated vagina cleaning liquid and a preparing process thereof - Google Patents
An encapsulated vagina cleaning liquid and a preparing process thereof Download PDFInfo
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Abstract
An encapsulated vagina cleaning liquid is disclosed. The encapsulated vagina cleaning liquid comprises 3-5 parts by weight of alkannin prepared through CO2 supercritical extraction, 1-2 parts by weight of fibralactone prepared through CO2 supercritical extraction, 4-5 parts by weight of propolis prepared through CO2 supercritical extraction, 83-88 parts by weight of purple perilla seed oil prepared through CO2 supercritical extraction, 1-2 parts by weight of egg yolk lecithin and 2-4 parts by weight of Chinese angelica ligustilide, with the encapsulated vagina cleaning liquid being 100 parts by weight. A preparing process includes heating the purple perilla seed oil prepared through CO2 supercritical extraction to 55-65 DEG C, adding 1 part of the weighed fibralactone, 4 parts of the alkannin, 5 parts of the propolis, 2 parts of the egg yolk lecithin and 3 parts of the Chinese angelica ligustilide in order, stirring for 20-40 min with a speed being 20-25 r/min to form jelly, allowing the jelly to stand for 7-9 h, sieving with a sieve having a size of 70-90 meshes, and forming through compression through a soft capsule production line. A prescription is formed through researching the encapsulated vagina cleaning liquid. The encapsulated vagina cleaning liquid is simple in formula, has good treating functions for viral infection of female genital tracts and has a good healthcare function for improving functions of female genital cavities.
Description
Technical field
Female reproductive system of the present invention treatment and healthcare field, refer in particular to a kind of encapsulated liquid for cleaning private part and preparation technology thereof.
Background technology
Due to the special tectonic of female reproductive system, and the own physiological feature of women, the problem of female reproductive system is always up an important component part of medical research.After western industrial revolution, western medicine is day by day ripe, and the department of obstetrics and gynecology of doctor trained in Western medicine become the important subject in clinical medicine, and western medicine achieves great successes at the clinical treatment of the upper development in science and technology also department of obstetrics and gynecology of operative treatment and Drug therapy.And the traditional Chinese medical science is produced for women's band tire and is called female section ancient times, a lot of documents is also being had to record on the middle Biography of Medical Figures of thousands of years and clinical effect.Motherland's medical science and modern medicine all have passed through long-term practice for the healthy reproduction of women in human health history development procedure and also achieve more experience.
Along with the development of industrial civilization, there is very big change in natural environment and social environment therewith, and human diseases spectrum also there occurs certain change, and along with the raising day by day of people's living standard, women in own health it is also proposed that higher demand.The healthy reproduction health care of women has developed into the reply of the spectrum change that is faced with a new disease and to the multi-level demands such as self daily health caring demand from simple Treatment need.Therefore, just there is certain realistic meaning for the technology of these demands and formulating.
Women is due to the open architecture of reproductive system, genital infection disease is occurred frequently, also it is the part that in female reproduction Treatment need, weight is maximum, especially the opening of economic opening and idea, people lived and exchange convenient while also make female reproduction transmissible disease in rapid rising；Female reproductive system catch spectrum also from single reproductive system pathogenic bacterial infection to special pathogenic bacteria, viral infection shifting type, according to domestic epidemiology examination add up, the disease that HPV infection causes makes the sickness rate of women at rapid increase；Current scientific research is it has been shown that the high-risk HPV persistent infection of cervix uteri can cause cervical cancer.So, how to remove the infection of cervix uteri, women's health is extremely important by the generation preventing cervical cancer early.The generation of this class disease, except the factor of circulation way, patient's autoimmune is also lowly main pathogenic factors.Modern medicine is mainly antagonism treatment for the Therapeutic Principle of female reproduction infectious disease, mainly has operation method, pharmaceutical methods, immunization method, and clinical treatment has certain effect, there is also the deficiency of the aspects such as also wound, side effect and immune effect difference.Excellent culture based on motherland's medical science, utilize the broad-spectrum curing effect of natural drug, adopt the purification of tcm means of modern biotechnology, make in the treatment that female reproductive system infects so that in the thorny disease of HPV infection, open wide treatment prospect.The more ecosystem cure theory of the traditional Chinese medical science is still embodied in: kills pathogen, suppress viral growth, protection profitable strain, recovers immune function.
The dysfunction of female reproductive system is also FAQs urgently to be resolved hurrily, middle and aged women changes along with health degeneration, the reduction of human body estrogen, gradually the metabolism of vaginal mucosa cell can be made to weaken, secreting less, it is less that this kind of middle and aged women often shows as vaginal secretions, feels vaginal dryness, senile vaginitis is much a kind of aseptic inflammation, and Symptoms is also vaginal dryness.This kind of female reproductive system problem is actually caused by hypofunction, adjust female incretion, recover local mucous membrane cell function be solve such issues that basic method.
Along with expanding economy, health of people life it is also proposed new requirement, except sexual desire, function improves demand, and operational maintenance liquid becomes the demand of women gradually, when vagina mucosa is dry and astringent, dyspareunia is exactly recurrent problem, there is the sterilization gellike agent of lubrication, although can the of short duration dry and astringent discomfort alleviating contact, but life-time service be unfavorable for intravaginal rings border.It therefore meets what both can alleviate in short-term is dry and astringent, again can life-time service, simultaneously by life-time service to vaginal mucosa function in protection with improvement result, be only the direction of female reproduction health preparation exploitation.
Summary of the invention
The technical problem to be solved in the present invention is for above-mentioned the deficiencies in the prior art, it is provided that a kind of encapsulated liquid for cleaning private part and preparation technology thereof.
The technical scheme that the present invention takes is as follows: a kind of encapsulated liquid for cleaning private part, every 100 weight portions include following raw material: carbon dioxide supercritical fluid extraction shikonin 3-5 part, carbon dioxide supercritical fluid extraction Caulis Fibraureae ester 1-2 part, carbon dioxide supercritical fluid extraction propolis 4-5 part, carbon dioxide supercritical fluid extraction Oleum Perillae 83-88, Ovum Gallus domesticus Flavus lecithin 1-2 part, angelica ligustilide 2-4 part.
Preferably, weight is divided preferably, carbon dioxide supercritical fluid extraction shikonin 4 parts, carbon dioxide supercritical fluid extraction propolis 5 parts, carbon dioxide supercritical fluid extraction Caulis Fibraureae ester 1 part, Ovum Gallus domesticus Flavus lecithin 2 parts, angelica ligustilide 3 parts, carbon dioxide supercritical fluid extraction Oleum Perillae 85 parts.
The preparation technology of a kind of encapsulated liquid for cleaning private part, comprises the following steps,
S1, prepare carbon dioxide supercritical fluid extraction shikonin, carbon dioxide supercritical fluid extraction propolis, carbon dioxide supercritical fluid extraction Caulis Fibraureae ester, Ovum Gallus domesticus Flavus lecithin, angelica ligustilide and carbon dioxide supercritical fluid extraction Oleum Perillae respectively；
S2, take the carbon dioxide supercritical fluid extraction shikonin 4 parts of weight portion, carbon dioxide supercritical fluid extraction propolis 5 parts, carbon dioxide supercritical fluid extraction Caulis Fibraureae ester 1 part, Ovum Gallus domesticus Flavus lecithin 2 parts, angelica ligustilide 3 parts and carbon dioxide supercritical fluid extraction Oleum Perillae 85 parts respectively；
S3, take weight portion in step S2 carbon dioxide supercritical fluid extraction Oleum Perillae heat to 55-65 DEG C, then the Caulis Fibraureae ester, shikonin, propolis, Ovum Gallus domesticus Flavus lecithin and the angelica ligustilide that weigh it are sequentially added into, in 20-25r/min when, stir 20-40min, form jelly；
S4, the jelly in step S3 is stood after 7-9h, cross 70-90 eye mesh screen, and compressing through soft capsule production line.
Preferably, in step S3, heating-up temperature is preferably 60 DEG C, and stirring condition is preferably preferred 20r/min, the preferred 30min of mixing time；In above-mentioned steps S4, the time of repose of jelly is preferably 8h, and screen cloth is preferably 80 eye mesh screens.
Preferably, in step S1, the preparation technology of carbon dioxide supercritical fluid extraction propolis is, propolis virgin rubber is loaded in carbon dioxide supercritical fluid extraction still, add the dehydrated alcohol of virgin rubber weight 60% as entrainer, circulation adds carbon dioxide liquid cycling extraction, extraction temperature is set as 30 DEG C, extraction pressure setting is 11MPa, extraction time is 2.5 hours, rear decompression Distillation recovery ethanol, extraction and recovery obtains the mixture that flavone is master of the terpenes containing 3% and 95%, and the weight of total mixture is the 6% of virgin rubber.
Preferably, in step S1, the preparation technology of carbon dioxide supercritical fluid extraction shikonin is, the dry coarse powder of Radix Arnebiae (Radix Lithospermi) is added in carbon dioxide supercritical fluid extraction still, add the dehydrated alcohol of Radix Arnebiae (Radix Lithospermi) weight 60% as entrainer, circulation adds carbon dioxide liquid cycling extraction, extraction temperature is set as 23 DEG C, extraction pressure setting is 10MPa, extraction time is 2 hours, rear decompression Distillation recovery ethanol, extraction and recovery obtains containing the mixture being main component with acetylshikonin, and the weight of mixture is add Radix Arnebiae (Radix Lithospermi) 7%.
Preferably, in step S1, the preparation technology of carbon dioxide supercritical fluid extraction Caulis Fibraureae ester is, Caulis Fibraureae root powder become coarse powder add in carbon dioxide supercritical fluid extraction still, add the dehydrated alcohol of Caulis Fibraureae raw material weight 60% as entrainer, circulation adds carbon dioxide liquid cycling extraction, extraction temperature is set as 28 DEG C, extraction pressure setting is 13MPa, extraction time is 3 hours, rear decompression Distillation recovery ethanol, it is the mixture of main component that extraction and recovery obtains containing fibralactone and Caulis Fibraureae A prime, and the weight of mixture is add Caulis Fibraureae raw material 4%.
Preferably, in step S1, the preparation technology of carbon dioxide supercritical fluid extraction lecithin is, yolk powder is added in carbon dioxide supercritical fluid extraction still, add the dehydrated alcohol of yolk powder weight 40% as entrainer, circulation adds carbon dioxide liquid cycling extraction, extraction temperature is set as 28 DEG C, extraction pressure setting is 12MPa, extraction time is 2 hours, rear decompression Distillation recovery ethanol, extraction and recovery obtains the mixture containing Ovum Gallus domesticus Flavus lecithin and neutral fat, and the weight of mixture is add yolk powder 20%.
Preferably, in step S1, the preparation technology of carbon dioxide supercritical fluid extraction Oleum Perillae is, to add in carbon dioxide supercritical fluid extraction still after Fructus Perillae coarse crushing, add the dehydrated alcohol of Fructus Perillae coarse crushing raw material weight 50% as entrainer, circulation adds carbon dioxide liquid cycling extraction, extraction temperature is set as 28 DEG C, extraction pressure setting is 11MPa, extraction time is 1 hour, rear decompression Distillation recovery ethanol, extraction and recovery obtains Oleum Perillae, and the weight of Oleum Perillae is add Fructus Perillae coarse crushing weight 40%.
Preferably, in step S1, the preparation technology of angelica ligustilide is, angelica sinensis being ground into 30 orders, puts in carbon dioxide supercritical fluid extraction still, extraction kettle pressure setting is 15MPa, extraction temperature is set as 40 DEG C, carbon dioxide flow is 15kg/ hour, and extraction time is 2 hours, extract volatile oil is crude drug weight 3%；Drying with anhydrous sodium sulfate, separated by silicagel column on volatile oil, with the mixture eluting of normal butane Yu acetone, fling to solvent after being merged by the component of ligustilide, the mixture received is 68% containing ligustilide.
The beneficial effects of the present invention is:
The technical problem to be solved is to provide a kind of natural drug composition that female reproduction tract has extensively treatment and health-care effect.Said composition has good therapeutical effect in the cervicitis treatment that female reproduction tract HPV infection causes, and the dry and astringent disease of vagina mucosa is had good health effect of conditioning, and the operational maintenance for female reproduction tract is also a kind of excellent day used additives.Use through experimentation and concept clinical and prove, the invention have the advantages that
1, the formula of present invention natural material composition has good effect in the cervicitis treatment that clinical gynecological is caused by HPV infection, clinical observation shows: coordinate this pharmaceutical formulation in the chronic cervicitis treatment merge HPV infection, slight rotten to the corn face healing, redness can be made to disappear, and cure rate reaches 80%.Merging simple this pharmaceutical formulation of use in the chronic cervicitis treatment of HPV infection in gynecological, cure rate reaches 60%, and this pharmaceutical formulation can use the long period, and have no drug resistance generation；In the treatment of chronic chronic cervicitis, twice on the one, one time one, within 10th, be a course for the treatment of.
2, inventive formulation preparation effect in the health therapy of middle and aged women colpoxerosis is notable; the vaginal secretions of middle and aged women vaginal dryness and climacteric women reduce be women estrogen level lowly caused by; the propolis flavone of this pharmaceutical formulation has anthropoid flavone sample effect; itself has mucosa; coordinate the application of ligustilide, lecithin; improve local microcirculation; add the tissue adherence absorption for flavonoid substances; therefore improve the Secretion of local mucous membrane, decrease and guide dry and astringent symptom to occur；Therapeutic Method is: once a day, each one, within 7th, is a course for the treatment of.
3, the daily reproductive health care of normal female is being used function well by inventive formulation preparation, uses one before couple's sexual life, increases the generation of smooth and easy, the prevention genital infection disease of sexual intercourse；When female mental is nervous, operating pressure strengthens and there will be increasing or reducing of certain vaginal secretions, but clinical diagnosis still can not qualitative for disease time, as health care use every three days one, leucorrhea secretion situation can be improved, improve the resistance against diseases of female reproduction tract, improve Reproductive Performance health degree, inventive formulation belong to natural material composition, can life-time service, have no side effect and drug resistance produce.
Detailed description of the invention
The invention will be further described below:
The technical scheme that the present invention takes is as follows: a kind of encapsulated liquid for cleaning private part, every 100 weight portions include following raw material: carbon dioxide supercritical fluid extraction shikonin 3-5 part, carbon dioxide supercritical fluid extraction Caulis Fibraureae ester 1-2 part, carbon dioxide supercritical fluid extraction propolis 4-5 part, carbon dioxide supercritical fluid extraction Oleum Perillae 83-88, Ovum Gallus domesticus Flavus lecithin 1-2 part, angelica ligustilide 2-4 part.
Weight is divided preferably, carbon dioxide supercritical fluid extraction shikonin 4 parts, carbon dioxide supercritical fluid extraction propolis 5 parts, carbon dioxide supercritical fluid extraction Caulis Fibraureae ester 1 part, Ovum Gallus domesticus Flavus lecithin 2 parts, angelica ligustilide 3 parts, carbon dioxide supercritical fluid extraction Oleum Perillae 85 parts.
The preparation technology of a kind of encapsulated liquid for cleaning private part, comprises the following steps,
S1, prepare carbon dioxide supercritical fluid extraction shikonin, carbon dioxide supercritical fluid extraction propolis, carbon dioxide supercritical fluid extraction Caulis Fibraureae ester, Ovum Gallus domesticus Flavus lecithin, angelica ligustilide and carbon dioxide supercritical fluid extraction Oleum Perillae respectively；
S2, take the carbon dioxide supercritical fluid extraction shikonin 4 parts of weight portion, carbon dioxide supercritical fluid extraction propolis 5 parts, carbon dioxide supercritical fluid extraction Caulis Fibraureae ester 1 part, Ovum Gallus domesticus Flavus lecithin 2 parts, angelica ligustilide 3 parts and carbon dioxide supercritical fluid extraction Oleum Perillae 85 parts respectively；
S3, take weight portion in step S2 carbon dioxide supercritical fluid extraction Oleum Perillae heat to 55-65 DEG C, then the Caulis Fibraureae ester, shikonin, propolis, Ovum Gallus domesticus Flavus lecithin and the angelica ligustilide that weigh it are sequentially added into, in 20-25r/min when, stir 20-40min, form jelly；
S4, the jelly in step S3 is stood after 7-9h, cross 70-90 eye mesh screen, and compressing through soft capsule production line.
In step S3, heating-up temperature is preferably 60 DEG C, and stirring condition is preferably preferred 20r/min, the preferred 30min of mixing time；In above-mentioned steps S4, the time of repose of jelly is preferably 8h, and screen cloth is preferably 80 eye mesh screens.
In step S1, the preparation technology of carbon dioxide supercritical fluid extraction propolis is, being loaded by propolis virgin rubber in carbon dioxide supercritical fluid extraction still, add the dehydrated alcohol of virgin rubber weight 60% as entrainer, circulation adds carbon dioxide liquid cycling extraction, extraction temperature is set as 30 DEG C, extraction pressure setting is 11MPa, and extraction time is 2.5 hours, rear decompression Distillation recovery ethanol, extraction and recovery obtains the mixture that flavone is master of the terpenes containing 3% and 95%, and the weight of total mixture is the 6% of virgin rubber.
In step S1, the preparation technology of carbon dioxide supercritical fluid extraction shikonin is, the dry coarse powder of Radix Arnebiae (Radix Lithospermi) is added in carbon dioxide supercritical fluid extraction still, add the dehydrated alcohol of Radix Arnebiae (Radix Lithospermi) weight 60% as entrainer, circulation adds carbon dioxide liquid cycling extraction, extraction temperature is set as 23 DEG C, extraction pressure setting is 10MPa, extraction time is 2 hours, rear decompression Distillation recovery ethanol, extraction and recovery obtains containing the mixture being main component with acetylshikonin, and the weight of mixture is add Radix Arnebiae (Radix Lithospermi) 7%.
In step S1, the preparation technology of carbon dioxide supercritical fluid extraction Caulis Fibraureae ester is, Caulis Fibraureae root powder become coarse powder add in carbon dioxide supercritical fluid extraction still, add the dehydrated alcohol of Caulis Fibraureae raw material weight 60% as entrainer, circulation adds carbon dioxide liquid cycling extraction, extraction temperature is set as 28 DEG C, extraction pressure setting is 13MPa, extraction time is 3 hours, rear decompression Distillation recovery ethanol, it is the mixture of main component that extraction and recovery obtains containing fibralactone and Caulis Fibraureae A prime, and the weight of mixture is add Caulis Fibraureae raw material 4%.
In step S1, the preparation technology of carbon dioxide supercritical fluid extraction lecithin is, being added by yolk powder in carbon dioxide supercritical fluid extraction still, add the dehydrated alcohol of yolk powder weight 40% as entrainer, circulation adds carbon dioxide liquid cycling extraction, extraction temperature is set as 28 DEG C, extraction pressure setting is 12MPa, and extraction time is 2 hours, rear decompression Distillation recovery ethanol, extraction and recovery obtains the mixture containing Ovum Gallus domesticus Flavus lecithin and neutral fat, and the weight of mixture is add yolk powder 20%.
In step S1, the preparation technology of carbon dioxide supercritical fluid extraction Oleum Perillae is, to add in carbon dioxide supercritical fluid extraction still after Fructus Perillae coarse crushing, add the dehydrated alcohol of Fructus Perillae coarse crushing raw material weight 50% as entrainer, circulation adds carbon dioxide liquid cycling extraction, extraction temperature is set as 28 DEG C, extraction pressure setting is 11MPa, and extraction time is 1 hour, rear decompression Distillation recovery ethanol, extraction and recovery obtains Oleum Perillae, and the weight of Oleum Perillae is add Fructus Perillae coarse crushing weight 40%.
In step S1, the preparation technology of angelica ligustilide is, angelica sinensis is ground into 30 orders, put in carbon dioxide supercritical fluid extraction still, extraction kettle pressure setting is 15MPa, and extraction temperature is set as 40 DEG C, and carbon dioxide flow is 15kg/ hour, extraction time is 2 hours, extract volatile oil is crude drug weight 3%；Drying with anhydrous sodium sulfate, separated by silicagel column on volatile oil, with the mixture eluting of normal butane Yu acetone, fling to solvent after being merged by the component of ligustilide, the mixture received is 68% containing ligustilide.
Further, the present invention is made up of the raw material of following weight portion: carbon dioxide supercritical fluid extraction shikonin 4 parts, carbon dioxide supercritical fluid extraction propolis 5 parts, carbon dioxide supercritical fluid extraction Caulis Fibraureae ester 1 part, Ovum Gallus domesticus Flavus lecithin 2 parts, angelica ligustilide 3 parts, carbon dioxide supercritical fluid extraction Oleum Perillae 85 parts.
Comprise the following steps: weigh each component raw material by following weight: shikonin 4 parts, propolis 5 parts, Caulis Fibraureae ester 1 part, 2 parts of angelica ligustilides of lecithin 3 parts, Oleum Perillae 85 parts；First the Oleum Perillae weighed is heated to 60 DEG C, be then sequentially added into weigh Caulis Fibraureae ester, propolis, shikonin, lecithin, angelica ligustilide, in 20r/min when stir 30min；After standing 8 hours, cross 80 eye mesh screens, compressing through soft capsule production line.
Further, the present invention is according to based on motherland's theory of medicine, new discovery is composed for research direction with new period female genital disorders, new results in conjunction with the new treatment concept of Clinical Science, application modern biotechnology, grope to form prescription through long-term research, formula is brief, compatibility is reasonable, and the viral infection of female reproduction tract is had good therapeutical effect by this formula, and the functional change for female reproduction chamber has good health-care effect.There is substantial amounts of effect to record in clinical practice, be a kind of collection female reproductive system infectious disease treatment, especially with HPV infection treatment, function conditioning, routine servicing in the external preparation formula of one.This formula takes on a red color liquid oil preparation, and after gelatin inclusion, form is soft capsule.
The pharmacological action of shikonin: shikonin be the natural plants lithospermum euchromum Royle ethanol of 60% do entrainer by carbon dioxide sub critical abstraction technique prepare, oil-soluble shikonin is one group of naphthalene Quinone Pigments, including shikonin, deoxyshikonin, acetylshikonin etc., effect that the natural Radix Arnebiae (Radix Lithospermi) classic of TCM is recorded is removing heat from blood rash, heat-clearing and toxic substances removing, and multi-component oil-soluble shikonin pharmacological evaluation proves: have antiinflammatory, antipyretic, anti-multiple pathogenic microorganisms and antineoplastic action, clinical prove for scald and skin mucosa chronic injury and chronic persistent inflammation curative effect better.
The pharmacological action of Caulis Fibraureae ester: Caulis Fibraureae ester is a kind of plant mixture adopting the root of menispermaceous plants fibraurea recisa to extract through carbon dioxide supercritical fluid extraction technology, is mainly composed of fibralactone and fibranine.The classic of TCM is recorded fibraurea recisa and is had effect of heat-clearing and toxic substances removing, diuresis relieving constipation；Modern pharmacological research finds that it has broad-spectrum antibacterial antiviral effect, it will be apparent that increase phagocytic activity of leukocytes, the effect of good antiinflammatory and increase immunity.Obtaining Caulis Fibraureae ester through carbon dioxide supercritical fluid extraction, biological purity is higher, and zest and side effect are extremely low, is especially suitable for external purposes.
The pharmacological action of propolis: the propolis of nature is called virgin rubber, and composition mixes, it is impossible to use directly as medicine and raw material, necessary extraction purification, propolis virgin rubber mainly contain substantial amounts of propolis flavone, and containing some terpene compounds, be all the main functional component of propolis；Preparing propolis terpenes flavone by carbon dioxide sub critical equipment, eliminate the multiple foreign material such as waxiness, main component is refined and purification.Propolis flavone mainly has antioxidation, protection mucosa and trace parahormone effect, and terpene compound just has the effect of broad-spectrum antibacterial antiviral, and normal flora has good protective effect.
The pharmacological action of Ovum Gallus domesticus Flavus lecithin: lecithin and protein and vitamin also claim " the 3rd nutrient ", are the main components constituting cell membrane, are the important substance safeguarding cell with mucosal function.The lecithin adopting carbon dioxide supercritical fluid extraction technology to extract from yolk powder, to splendid with cell and mucosa maintenance effect, also has fabulous moisturizing lubrication.
The pharmacological action of angelica ligustilide: another name ligustilide, it it is the main active of Radix Angelicae Sinensis oil, with artificial growth when being classified as material, steam distillation is adopted to prepare through purification after extracting, ligustilide can improve microcirculation, antibacterial, raising immunity of organisms, confirms to treat bronchitis and various gynecological diseases in clinical practice.
The pharmacological action of Oleum Perillae: Oleum Perillae does the use of solvent in this natural drug composition, Oleum Perillae is vegetable oil the highest containing alpha linolenic acid in crude vegetal, the content of alpha linolenic acid is about 70%, alpha linolenic acid is as the part that growth, cellular metabolism and muscular movement energy supply are its function, they are more is as structural material and metabolic regulation material, plays structure function and adjusting function.Folium Perillae is recorded at the classic of TCM just antiabortive effect, and modern pharmacological research proves, Oleum Perillae has certain antiinflammatory, suppresses the effect of allergy.
The development of the natural drug composition of the present embodiment, conception is in that based on treatment, reinforced immunological function, being aided with health care conditioning, life maintenance, the reasonable recipe of compositions, prepare consummate, using dosage is little, application crowd only needs natural drug composition 0.5g-1g namely to have effect every day.
The present invention experienced by the research of decade-long pharmaceutical preparation technology and long-term clinical observation experiment, hygiene inspection, antibacterial inspection, cutaneous safety inspection are repeatedly carried out, clinical observation shows: coordinate this pharmaceutical formulation to treat in the chronic cervicitis treatment merge HPV infection, curative effect is conclusive, cure rate 80%；And the relapse rate of cervicitis can be substantially reduced.Simple this pharmaceutical formulation of use in the chronic cervicitis treatment merge HPV infection, cure rate reaches 60%, respond well, and this pharmaceutical formulation can use by longer-term, and have no drug resistance generation；Inventive formulation preparation effect in the health therapy of middle and aged women colpoxerosis is notable；Inventive formulation preparation, in the daily reproductive health care to normal female, improves leucorrhea secretion situation, improves the resistance against diseases of female reproduction tract, improve the aspect function well such as Reproductive Performance.
December in May, 2005 to 2013 carried out long-term clinical observation:
A uses this pharmaceutical formulation in merging the partner treatment of chronic cervicitis of HPV infection, clinical observation number 257
Example, wherein cures 176 examples, effective 69 examples, invalid 12 examples, follows the tracks of to observe to cure accounting for 75% without recidivist.
B uses merely this pharmaceutical formulation clinical observation 187 example in merging the individually treatment of chronic cervicitis of HPV infection, wherein cures 112 examples, effective 65 examples, invalid 10 examples.Follow the tracks of to observe to cure and account for 60% without recidivist.
C uses merely this pharmaceutical formulation in old aseptic vaginitis, vaginal dryness health care maintenance, and clinical observation 334 example, wherein effective percentage is 98%.
D uses merely the clinical observation that infertility is treated by this pharmaceutical formulation, applies patient 9 example, and treatment is 30 180 days, and wherein becoming pregnant is 6 examples.
This pharmaceutical formulation of E uses as female life health care and love life auxiliary agent, throws in as hygienic article is existing in market, and market reaction is extensively good.
Embodiments of the invention simply introduce its detailed description of the invention, do not lie in and limit its protection domain.The technical staff of the industry may be made that some is revised under the inspiration of the present embodiment, therefore all equivalences done according to the scope of the claims of the present invention change or modify, and belong within the scope of Patent right requirement of the present invention.
Claims (10)
1. an encapsulated liquid for cleaning private part, it is characterised in that: every 100 weight portions include following raw material: carbon dioxide supercritical fluid extraction shikonin 3-5 part, carbon dioxide supercritical fluid extraction Caulis Fibraureae ester 1-2 part, carbon dioxide supercritical fluid extraction propolis 4-5 part, carbon dioxide supercritical fluid extraction Oleum Perillae 83-88, Ovum Gallus domesticus Flavus lecithin 1-2 part, angelica ligustilide 2-4 part.
2. a kind of encapsulated liquid for cleaning private part according to claim 1, it is characterized in that: described weight is divided preferably, carbon dioxide supercritical fluid extraction shikonin 4 parts, carbon dioxide supercritical fluid extraction propolis 5 parts, carbon dioxide supercritical fluid extraction Caulis Fibraureae ester 1 part, Ovum Gallus domesticus Flavus lecithin 2 parts, angelica ligustilide 3 parts, carbon dioxide supercritical fluid extraction Oleum Perillae 85 parts.
3. the preparation technology of an encapsulated liquid for cleaning private part as claimed in claim 1, it is characterised in that: comprise the following steps,
S1, prepare carbon dioxide supercritical fluid extraction shikonin, carbon dioxide supercritical fluid extraction propolis, carbon dioxide supercritical fluid extraction Caulis Fibraureae ester, Ovum Gallus domesticus Flavus lecithin, angelica ligustilide and carbon dioxide supercritical fluid extraction Oleum Perillae respectively；
S2, take the carbon dioxide supercritical fluid extraction shikonin 4 parts of weight portion, carbon dioxide supercritical fluid extraction propolis 5 parts, carbon dioxide supercritical fluid extraction Caulis Fibraureae ester 1 part, Ovum Gallus domesticus Flavus lecithin 2 parts, angelica ligustilide 3 parts and carbon dioxide supercritical fluid extraction Oleum Perillae 85 parts respectively；
S3, take weight portion in step S2 carbon dioxide supercritical fluid extraction Oleum Perillae heat to 55-65 DEG C, then the Caulis Fibraureae ester, shikonin, propolis, Ovum Gallus domesticus Flavus lecithin and the angelica ligustilide that weigh it are sequentially added into, in 20-25r/min when, stir 20-40min, form jelly；
S4, the jelly in step S3 is stood after 7-9h, cross 70-90 eye mesh screen, and compressing through soft capsule production line.
4. the preparation technology of a kind of encapsulated liquid for cleaning private part according to claim 3, it is characterised in that: in described step S3, heating-up temperature is preferably 60 DEG C, and stirring condition is preferably preferred 20r/min, the preferred 30min of mixing time；In above-mentioned steps S4, the time of repose of jelly is preferably 8h, and screen cloth is preferably 80 eye mesh screens.
5. the preparation technology of a kind of encapsulated liquid for cleaning private part according to claim 4, it is characterized in that: in described step S1, the preparation technology of carbon dioxide supercritical fluid extraction propolis is, propolis virgin rubber is loaded in carbon dioxide supercritical fluid extraction still, add the dehydrated alcohol of virgin rubber weight 60% as entrainer, circulation adds carbon dioxide liquid cycling extraction, extraction temperature is set as 30 DEG C, extraction pressure setting is 11MPa, extraction time is 2.5 hours, rear decompression Distillation recovery ethanol, extraction and recovery obtains the mixture that flavone is master of the terpenes containing 3% and 95%, the weight of total mixture is the 6% of virgin rubber.
6. the preparation technology of a kind of encapsulated liquid for cleaning private part according to claim 4, it is characterized in that: in described step S1, the preparation technology of carbon dioxide supercritical fluid extraction shikonin is, the dry coarse powder of Radix Arnebiae (Radix Lithospermi) is added in carbon dioxide supercritical fluid extraction still, add the dehydrated alcohol of Radix Arnebiae (Radix Lithospermi) weight 60% as entrainer, circulation adds carbon dioxide liquid cycling extraction, extraction temperature is set as 23 DEG C, extraction pressure setting is 10MPa, extraction time is 2 hours, rear decompression Distillation recovery ethanol, extraction and recovery obtains containing the mixture being main component with acetylshikonin, the weight of mixture is add Radix Arnebiae (Radix Lithospermi) 7%.
7. the preparation technology of a kind of encapsulated liquid for cleaning private part according to claim 4, it is characterized in that: in described step S1, the preparation technology of carbon dioxide supercritical fluid extraction Caulis Fibraureae ester is, Caulis Fibraureae root powder become coarse powder add in carbon dioxide supercritical fluid extraction still, add the dehydrated alcohol of Caulis Fibraureae raw material weight 60% as entrainer, circulation adds carbon dioxide liquid cycling extraction, extraction temperature is set as 28 DEG C, extraction pressure setting is 13MPa, extraction time is 3 hours, rear decompression Distillation recovery ethanol, it is the mixture of main component that extraction and recovery obtains containing fibralactone and Caulis Fibraureae A prime, the weight of mixture is add Caulis Fibraureae raw material 4%.
8. the preparation technology of a kind of encapsulated liquid for cleaning private part according to claim 4, it is characterized in that: in described step S1, the preparation technology of carbon dioxide supercritical fluid extraction lecithin is, yolk powder is added in carbon dioxide supercritical fluid extraction still, add the dehydrated alcohol of yolk powder weight 40% as entrainer, circulation adds carbon dioxide liquid cycling extraction, extraction temperature is set as 28 DEG C, extraction pressure setting is 12MPa, extraction time is 2 hours, rear decompression Distillation recovery ethanol, extraction and recovery obtains the mixture containing Ovum Gallus domesticus Flavus lecithin and neutral fat, the weight of mixture is add yolk powder 20%.
9. the preparation technology of a kind of encapsulated liquid for cleaning private part according to claim 4, it is characterized in that: in described step S1, the preparation technology of carbon dioxide supercritical fluid extraction Oleum Perillae is, to add in carbon dioxide supercritical fluid extraction still after Fructus Perillae coarse crushing, add the dehydrated alcohol of Fructus Perillae coarse crushing raw material weight 50% as entrainer, circulation adds carbon dioxide liquid cycling extraction, extraction temperature is set as 28 DEG C, extraction pressure setting is 11MPa, extraction time is 1 hour, rear decompression Distillation recovery ethanol, extraction and recovery obtains Oleum Perillae, the weight of Oleum Perillae is add Fructus Perillae coarse crushing weight 40%.
10. the preparation technology of a kind of encapsulated liquid for cleaning private part according to claim 4, it is characterized in that: in described step S1, the preparation technology of angelica ligustilide is, angelica sinensis being ground into 30 orders, puts in carbon dioxide supercritical fluid extraction still, extraction kettle pressure setting is 15MPa, extraction temperature is set as 40 DEG C, carbon dioxide flow is 15kg/ hour, and extraction time is 2 hours, extract volatile oil is crude drug weight 3%；Drying with anhydrous sodium sulfate, separated by silicagel column on volatile oil, with the mixture eluting of normal butane Yu acetone, fling to solvent after being merged by the component of ligustilide, the mixture received is 68% containing ligustilide.
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| CN201410791947.9A CN105748583A (en) | 2014-12-19 | 2014-12-19 | An encapsulated vagina cleaning liquid and a preparing process thereof |
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| CN201410791947.9A CN105748583A (en) | 2014-12-19 | 2014-12-19 | An encapsulated vagina cleaning liquid and a preparing process thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107961356A (en) * | 2018-01-23 | 2018-04-27 | 陕西靓帝生物科技有限责任公司 | Keep a public place clean for anus, clearly, maintenance, the external nursing product of Mucous rehabilitation |
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| CN101095895A (en) * | 2007-07-06 | 2008-01-02 | 韦建学 | Externally-used medicament for the sanitation and health-care of female vagina and for treating gynecology vagina diseases and method for making the same |
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| CN101095895A (en) * | 2007-07-06 | 2008-01-02 | 韦建学 | Externally-used medicament for the sanitation and health-care of female vagina and for treating gynecology vagina diseases and method for making the same |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107961356A (en) * | 2018-01-23 | 2018-04-27 | 陕西靓帝生物科技有限责任公司 | Keep a public place clean for anus, clearly, maintenance, the external nursing product of Mucous rehabilitation |
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