CN102836296A - Medicine for treating vascular endothelial injury, stenosis and occlusion of heart, brain and kidney mainly - Google Patents

Abstract

The invention provides a medicine for treating the vascular endothelial injury, the stenosis and the occlusion of the heart, the brain and the kidney mainly, which relates to a medicine of traditional Chinese medicines for treating diseases in the aspect of blood vessels. The medicine for treating the vascular endothelial injury, the stenosis and the occlusion of the heart, the brain and the kidney mainly is prepared by the following raw materials: 1 to 3 parts of radix salviae miltiorrhizae, 0.5 to 2 parts of radix notoginseng, 0.5 to 2 parts of leech, 0.5 to 2 parts of land tortoise plastron, 0.5 to 2 parts of crude turtle shell, 0.5 to 2 parts of scorpio, 0.5 to 2 parts of rhizoma alismatis, 0.5 to 2 parts of sea cucumber, 0.4 to 1.2 parts of ginseng and 0.1 to 0.4 parts of bear gall powder; when the medicine for treating the vascular endothelial injury, the stenosis and the occlusion of the heart, the brain and the kidney mainly is prepared, liquor is obtained after the operations of conventional alcohol extraction and water extraction are carried out on the raw materials except for the radix notoginseng, the sea cucumber and the bear gall; and the liquor is concentrated to clear paste of which the relative density is 1.32 to 1.40 (50 DEG C), then the clear paste is stirred with the pulverized matters of the radix notoginseng, the sea cucumber and the bear gall, and the mixture is dried so as to prepare particulate matters containing 17.4 percent of total sugar, 13.8 percent of protein, 180mg/100g of total flavone and 559mg/100g of total saponin. The medicine for treating the vascular endothelial injury, the stenosis and the occlusion of the heart, the brain and the kidney mainly has the following beneficial effects that the medicine for treating the vascular endothelial injury, the stenosis and the occlusion of the heart, the brain and the kidney mainly has a high curative effect, and no toxic or side effect, and is low in cost, and the phenomenon of relapse does not occur after healing; and by 69 cases of clinical trial, the effective rate is 99 percent, and the cure rate is 65 percent.

Description

A kind of heart and brain kidney of treating is main vascular endothelial injury, narrow, inaccessible medicine

Technical field

The present invention relates to the Chinese medicine technical field; Further be a kind of Chinese medicine medicine of treating blood vessel aspect disease, especially treat angiostenosis due to the factors such as swollen blood vessels, inflammation, endothelial injury, blood vessel elasticity reduce, the blood vessel endothelium attachment increases, inaccessible Chinese medicine medicine.

Background technology

Raising along with the reform and opening-up living standards of the people; Because the affluenza that angiostenosis causes, metabolism syndrome get more and more; The heart, brain, kidney, angiopathy, diabetes straight line rise; Sub-health population presses for good measure and Drug therapy intervention and improves people's holistic health also increasing.These sick medicines of treatment are medicinal in having at present: troxerutin, and Western medicine is used: these medicines of beniol, therapeutic effect is not obvious, and treatment time is long, and these medicine costs are high, high price is expensive, side effect is big.

Summary of the invention

The purpose of this invention is to provide a kind of heart and brain kidney of treating is main vascular endothelial injury, narrow, inaccessible medicine, and curative effect of the present invention is high, cost is low, have no side effect.

The objective of the invention is to realize through following scheme:

A kind of heart and brain kidney of treating is main vascular endothelial injury, narrow, inaccessible medicine, it is characterized in that it being to be processed by following raw material: Radix Salviae Miltiorrhizae 1-3 part, Radix Notoginseng 0.5-2 part, Hirudo 0.5-2 part, non-irrigated Carapax et Plastrum Testudinis 0.5-2 part, living Carapax Trionycis 0.5-2 part, Scorpio 0.5-2 part, Rhizoma Alismatis 0.5-2 part, Stichopus japonicus 0.5-2 part, Radix Ginseng 0.4-1.2 part, Fel Ursi powder 0.1-0.4 part.

Preferably: 2 parts of Radix Salviae Miltiorrhizaes, 1 part of Radix Notoginseng, 1 part of Hirudo, 1 part of non-irrigated Carapax et Plastrum Testudinis, 1 part of living Carapax Trionycis, 1 part of Scorpio, 1 part of Rhizoma Alismatis, 1 part of Stichopus japonicus, 0.8 part of Radix Ginseng, 0.2 part of Fel Ursi powder.

Processing technology of the present invention: above raw material except that Radix Notoginseng, Stichopus japonicus, Fel Ursi, by drawing medicinal liquid behind conventional alcohol extraction and the water extraction; Medicinal liquid is concentrated into relative density 1.32-1.40 (50 ℃) clear paste; Stir with the ground product (mixing or mix the back after 3 kinds of raw material pulverizing pulverizes) of Radix Notoginseng, Stichopus japonicus, Fel Ursi again; Drying is prepared the particulate matter that contains total sugar 17.4%, protein 13.8%, total flavones 180mg/100g, total Saponin 559mg/100g.Also can process other dosage forms such as capsule, tablet, oral liquid etc. by conventional method.

The present invention adopts following principle to realize: the present invention adopts: the A modern medicine: act on the heart, brain, kidney, skin, blood vessel, fatty nerve, a plurality of internal organs, accelerate the body metabolism, recover to strengthen blood vessel elasticity, thrombus is regulated blood component; B Chinese medicine: blood circulation promoting and blood stasis dispelling, dampness removing the turbid descending, logical heart and brain, relaxing muscles and tendons and activating QI and blood in the collateral, sending up the lucid YANG, the bright principle effect of refreshment realizes.

The invention has the beneficial effects as follows: curative effect of the present invention is high, have no side effect, cost is low, do not recur after more, through 69 routine clinical trial effective percentage 99%, and cure rate 65%.

Concrete manifestation is:

1, cardiovascular aspect, myocardial ischemia, coronary heart disease, cardiovascular are narrow, arrhythmia 2-5 all symptom and signs take a favorable turn, like chest pain, uncomfortable in chest, tachypnea three big sxs.Abnormal cardiac rate progressively takes a turn for the better, and pulse pressure difference slowly recovers normally, and conscious sb.'s illness took a favorable turn, effective percentage 99%, cure rate 65%.

2, cerebrovascular aspect: these article can be through improving blood parameters; Reduce plasma viscosity, reduce the blood plasma lipide peroxide; Blood vessel endothelium improves, angiostenosis is improved, and antiplatelet aggregation suppresses thromboxane and thrombin; Make thrombosis be difficult in cardiovascular and cerebrovascular vessel, assembling, can recover to create environment in the good brain for Cerebral Infarction Patients; Eliminate rotating ring joint of pathogenetic beginning of cardiovascular and cerebrovascular vessel, and have calcium channel blocking action, expansion of cerebral vascular, assurance cerebral tissue blood supply oxygen-supplying amount recover the neural effect of cerebral tissue, make neurological symptom and sign be able to comprehensively improve and rehabilitation.Using this product effective percentage 99% overwhelming majority through lots of clinical can cure fully.

3, these article of nephropathy have special result to many types of nephropathy, and such as hypertensive nephropathy, renal atrophy is June approximately, and the kidney of atrophy can progressively increase, reinstatement in about about 1 year.Kidney angiostenosis, edema all exist in all nephropathy, have improved this pass topic of kidney angiostenosis, and these article bring the light of improvement rehabilitation for all nephropathy, and albuminuria, occult blood, renal function can progressively take a turn for the better.The Patients with Chronic Renal Disease kidney vascular smooth muscle that when using these article, can relax, releasing vasospasm improves blood flow; Improve body to antigenic removing power, the damage of GBM is had repair, can make cell impaired, distortion swelling dwindle reinstatement; Can improve renal blood flow in addition; The serum creatinine discharge is accelerated, and promotes fibrous tissue to absorb, and makes the glomerule of useless usefulness be able to reparation and reach the elimination urine protein.Length according to the data of auxiliary examination, state of an illness weight, Time of Administration is different, and it is normal gradually to see the auxiliary examination data respectively, and sx, urine protein gradually reduce or disappearance, foam urine reduce, renal function improves until recovery from illness.

4, type-II diabetes is the extension of angiopathy, and the two is mutually promoted and increases the weight of the state of an illness, and angiopathy, dyslipidemia, blood constituent change short numerous type-II diabetes of having given birth to.Diabetes are not fearful; It is many organs and tissues angiostenosis of master with the heart, brain, kidney that diabetes that fearful is are quickened to form serious; Cause tissue ischemia, dyslipidemia, thrombosis, hypoinsulinism, opposing cause the dysbolismus property disease of disturbance of carbohydrate metabolism.And the regular treatment that diabetes and angiopathy can not get working along both lines causes the multisystem infringement.New clinical research is found: type-II diabetes is a microcirculation disturbance, and angiopathy morbidity takes place formerly, does not have clinical symptoms to get the brush-off and have, and progressively forms type-II diabetes." irritating plumbous lower limb " symptom of prediabetes and glycosuria stadium, this is the skelasthenia that causes owing to leg muscle hypoglycemia, leads to the little angiostenosis thickening of muscle; The vasodilation function reduces, and insulin can't be oozed out from blood vessel arrive in the muscle, and the sugar that obtains in the muscle reduces half the; Containing sugar level in the blood simultaneously increases; At this moment using " these article " a period of time does not add and use antidiabetic drug, and blood glucose target descends through chemical examination in various degree, can reduce to normally.

Below further prove effect of the present invention through clinical testing data:

1, cure mainly: the complication that coronary heart disease, cardiomyopathy, pulmonary heart disease, myocardial ischemia, type-II diabetes and type-II diabetes cause, nephropathy, renal insufficiency, albuminuria, uremia, cerebral infarction, apoplexy sequela, hypertension, optical fundus blood vessel disease, erythematous gastritis, superficial gastritis, colitis, intractable tubal occlusion are obstructed, and infertility, amenorrhea etc. are various because the disease that angiostenosis causes.

2, take angiopathy prescription and TONGXINLUO JIAONANG, routine is taken the contrast that Western medicine is kept method:

" name of ischemic heart desease and the diagnostic criteria " that diagnostic criteria for coronary heart disease is formulated with reference to WHO, the obstruction of qi in the chest and cardialgia diagnostic criteria is with reference to " the clinical research guideline of the new Chinese medicine treatment thoracic obstruction (angina pectoris) " of Ministry of Public Health formulation in 1993.Selection of clinical meets the patients with coronary heart disease of above-mentioned Chinese and western medicine diagnostic criteria.

Adopt dual analog randomized controlled method to observe the clinical efficacy of angiopathy prescription treatment coronary heart disease.Method: be divided into angiopathy prescription group, Tongxinluo group and keep group; The angiopathy prescription is organized 69 examples, and Tongxinluo group 67 examples are kept group 67 examples; Efficacy determination is a standard with " angina pectoris efficacy assessment standard ", divide recovery from illness, produce effects, effective, invalid, increase the weight of five grades.24 weeks of the course of treatment.The result is following:

The angiopathy prescription is kept method and is compared with TONGXINLUO JIAONANG, Western medicine:

Kind

Method

First month

March

June

One week of drug withdrawal

Drug withdrawal is followed up a case by regular visits to half a year

We

We add conventional medicine

94.6% effective controlling symptoms

80% can gradually reduce or inactive Western medicine

62% recovery from illness all medicines of can stopping using fully

38% symptom of being left alleviates in various degree

62% cured person does not have recurrence, 34% improvement in various degree of being left

TONGXINLUO JIAONANG

TONGXINLUO JIAONANG adds conventional medicine

96.67% effective controlling symptoms

Can reduce the Western medicine consumption

Any medicine of can not stopping using

All symptoms are all returned

No drug withdrawal patient

Routine is kept medicine

List is kept with conventional medicine

79.27% effective controlling symptoms

Can't reduce the Western medicine consumption

Any medicine of can not stopping using

All symptoms are all returned

No drug withdrawal patient

Ultrasonic Comparison of therapeutic after the drug withdrawal:

Group

Recovery from illness

Produce effects

Effectively

Invalid

Increase the weight of

Total effective rate

Angiopathy prescription group

17 examples

43 examples

7 examples

2 examples

0 example

96.25%

The Tongxinluo group

0 example

32 examples

17 examples

11 examples

7 examples

59.23%

Conventional group

0 example

0 example

8 examples

39 examples

20 examples

13.46%

ECG curative effect contrast after the drug withdrawal:

Group	Recovery from illness	Produce effects	Effectively	Invalid	Increase the weight of	Total effective rate
							Angiopathy prescription group	19	28	16	5	1	91.43%
The Tongxinluo group	0	29	18	13	7	64.2%
							Conventional group	0	5	18	33	11	40.58%

3, model case:

Case 1: Lu so-and-so, the man, 72 years old, retirement senior teacher in school, Hua County, Henan Province suffered from coronary heart disease for many years, tachypnea uncomfortable in chest is bad during the long-term fashion of symptom, meets the heavy obstinate of cold rnning.The winter state of an illness increased the weight of in 2002, was unable to leave the bed.Introduce through others, ask with not using any Western medicine, symptom took a favorable turn in 70 days, in the time of 2 months, had not had the cardiovascular symptom, continued with 1 course of treatment.The no abnormal index of repeatedly healthy experience.

Case 2: the king so-and-so, the man, 54 years old, Hua County, Henan Province cadre of local police station suffered from the concurrent for many years cerebral infarction sequela of diabetes, dull-witted, forgetful, slurred speech, dizzy companion's myocardial ischemia symptom.Through Duo Jia economize, city-level hospital obstinate, the chance of a chance is through taking, through with these article after 2 weeks, all disease improvements, when using to 50 days the cerebral infarction sequela symptom completely without, one the course of treatment heart and brain return to one's perfect health.

Case 3: the king so-and-so, the man, 76 years old, Hua County, Henan Province village cadre suffered from coronary heart disease, many places myocardial ischemia more than 20 year is suffered from tracheitis for many years, often outbreak.It is countless that the invalid hospital of living of emergency medicine is taken in angina pectoris, and walking is difficult, is famous old prolonged illness people, tachypnea when seeing and treating patients; Asthma, opening mouth and lifting shoulder due to dyspnea, the rhythm of the heart is being taken peace iodine ketolysis in addition 120 times/minute down; The arteria coronaria many places are narrow more than 90%, in these article of taking, take the isosorbide mononitrate sheet, and symptom is clearly better after 4 weeks; The Western medicine of stopping using for one course of treatment, heavier because of the oversize angiostenosis of its course of disease, take care of oneself like ordinary person 2 courses of treatment.After taking for 3 courses of treatment, asymptomatic.

Case 4: Lee so-and-so, man, 48 years old, area just outside a city gate town, Hua County, Henan Province peasant; Suffer from hypertensive nephropathy for many years, serum creatinine more than 300, the soreness of waist, dim eyesight; At Duo Jia province, city-level hospital obstinate, take through others' introduction, take 3 months serum creatinines and be reduced to 110umol/L.Four recoveries from illness course of treatment.

Case 5: the king so-and-so, the man, 61 years old, area just outside a city gate people from town, Hua County, Henan Province suffered from coronary heart disease, hypertension for many years, card see palpitation and restlessness, sensation of oppression over the chest with shortness of breath, the time dizzy, the face lip is livid purple slightly, enlarged tongue is dark, white, slippery and moist fur.Take these article upon somebody's introduction cured in three months.

Case 6: the king so-and-so, the man, 59 years old, road junction people from town, Hua County, Henan Province suffered from the concurrent for many years apoplexy sequela of hypertension, dull-witted, forgetful, slurred speech, dizziness.These article of taking are cured three courses of treatment.

Case 7: soup so-and-so, the man, 64 years old, people from Hua County, Henan Province, suffer from the hypertension and cerebral infraction card and see that dizziness, slurred speech walking are unfavorable, take two healings courses of treatment of these article.

Case 8: Jiang so-and-so, the woman, 56 years old, people from Hua County, Henan Province suffered from nephropathy for many years, creatinine is high, albuminuria is arranged, take 5 healings courses of treatment of these article.

The specific embodiment

In order to make those skilled in the art person understand the present invention program better, and make above-mentioned purpose of the present invention, feature and advantage can be more obviously understandable, below in conjunction with embodiment the present invention done further detailed explanation.

Embodiment 1:

A kind of heart and brain kidney of treating is main vascular endothelial injury, narrow, inaccessible medicine, chooses following raw material: 1 part of Radix Salviae Miltiorrhizae, 0.5 part of Radix Notoginseng, 0.5 part of Hirudo, 0.5 part of non-irrigated Carapax et Plastrum Testudinis, 0.5 part of living Carapax Trionycis, 0.5 part of Scorpio, 0.5 part of Rhizoma Alismatis, 0.5 part of Stichopus japonicus, 0.4 part of Radix Ginseng, 0.1 part of Fel Ursi powder.

During making, above raw material except that Radix Notoginseng, Stichopus japonicus, Fel Ursi, by drawing medicinal liquid behind conventional alcohol extraction and the water extraction; Medicinal liquid is concentrated into relative density 1.32-1.40 (50 ℃) clear paste, and the ground product with Radix Notoginseng, Stichopus japonicus, Fel Ursi stirs again, and drying is prepared the particulate matter that contains total sugar 17.4%, protein 13.8%, total flavones 180mg/100g, total Saponin 559mg/100g.Also can process other dosage forms such as capsule, tablet, oral liquid etc. by conventional method.

Embodiment 2:

A kind of heart and brain kidney of treating is main vascular endothelial injury, narrow, inaccessible medicine, chooses following raw material: 3 parts of Radix Salviae Miltiorrhizaes, 2 parts of Radix Notoginseng, 2 parts of Hirudos, 2 parts of non-irrigated Carapax et Plastrum Testudiniss, 2 parts of living Carapax Trionycis, 2 parts of Scorpios, 2 parts of Rhizoma Alismatis, 2 parts of Stichopus japonicuss, 1.2 parts of Radix Ginsengs, 0.4 part of Fel Ursi powder.

During making, above raw material except that Radix Notoginseng, Stichopus japonicus, Fel Ursi, by drawing medicinal liquid behind conventional alcohol extraction and the water extraction; Medicinal liquid is concentrated into relative density 1.32-1.40 (50 ℃) clear paste, and the ground product with Radix Notoginseng, Stichopus japonicus, Fel Ursi stirs again, and drying is prepared the particulate matter that contains total sugar 17.4%, protein 13.8%, total flavones 180mg/100g, total Saponin 559mg/100g.Also can process other dosage forms such as capsule, tablet, oral liquid etc. by conventional method.

Embodiment 3:

A kind of heart and brain kidney of treating is main vascular endothelial injury, narrow, inaccessible medicine, chooses following raw material: 2 parts of Radix Salviae Miltiorrhizaes, 1 part of Radix Notoginseng, 1 part of Hirudo, 1 part of non-irrigated Carapax et Plastrum Testudinis, 1 part of living Carapax Trionycis, 1 part of Scorpio, 1 part of Rhizoma Alismatis, 1 part of Stichopus japonicus, 0.8 part of Radix Ginseng, 0.2 part of Fel Ursi powder.

During making, above raw material except that Radix Notoginseng, Stichopus japonicus, Fel Ursi, by drawing medicinal liquid behind conventional alcohol extraction and the water extraction; Medicinal liquid is concentrated into relative density 1.32-1.40 (50 ℃) clear paste, and the ground product with Radix Notoginseng, Stichopus japonicus, Fel Ursi stirs again, and drying is prepared the particulate matter that contains total sugar 17.4%, protein 13.8%, total flavones 180mg/100g, total Saponin 559mg/100g.Also can process other dosage forms such as capsule, tablet, oral liquid etc. by conventional method.

The above; Be merely the specific embodiment of the present invention, but protection scope of the present invention is not limited thereto, any technical staff who is familiar with the present technique field is in the technical scope that the present invention discloses; The variation that can expect easily or replacement all should be encompassed within protection scope of the present invention.

Claims (3)

1. treat the vascular endothelial injury that the heart and brain kidney is the master, narrow, inaccessible medicine for one kind, it is characterized in that it being to process: Radix Salviae Miltiorrhizae 1-3 part, Radix Notoginseng 0.5-2 part, Hirudo 0.5-2 part, non-irrigated Carapax et Plastrum Testudinis 0.5-2 part, living Carapax Trionycis 0.5-2 part, Scorpio 0.5-2 part, Rhizoma Alismatis 0.5-2 part, Stichopus japonicus 0.5-2 part, Radix Ginseng 0.4-1.2 part, Fel Ursi powder 0.1-0.4 part by following raw material; During making, above raw material except that Radix Notoginseng, Stichopus japonicus, Fel Ursi, by drawing medicinal liquid behind conventional alcohol extraction and the water extraction; Medicinal liquid is concentrated into relative density 1.32-1.40 clear paste, and the ground product with Radix Notoginseng, Stichopus japonicus, Fel Ursi stirs again, and drying is prepared the particulate matter that contains total sugar 17.4%, protein 13.8%, total flavones 180mg/100g, total Saponin 559mg/100g.

2. treatment heart and brain kidney according to claim 1 is main vascular endothelial injury, narrow, inaccessible medicine, and it is characterized in that: the component of said raw material is: 2 parts of Radix Salviae Miltiorrhizaes, 1 part of Radix Notoginseng, 1 part of Hirudo, 1 part of non-irrigated Carapax et Plastrum Testudinis, 1 part of living Carapax Trionycis, 1 part of Scorpio, 1 part of Rhizoma Alismatis, 1 part of Stichopus japonicus, 0.8 part of Radix Ginseng, 0.2 part of Fel Ursi powder.

3. treatment heart and brain kidney according to claim 1 and 2 is main vascular endothelial injury, narrow, inaccessible medicine, it is characterized in that: manufacture method is to adopt conventional method to be made into capsule or tablet or oral liquid.