CN108403983A - Treat the stagnation resolvation Cyclandelate of cerebral infarction sequela - Google Patents

Treat the stagnation resolvation Cyclandelate of cerebral infarction sequela Download PDF

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CN108403983A
CN108403983A CN201810613929.XA CN201810613929A CN108403983A CN 108403983 A CN108403983 A CN 108403983A CN 201810613929 A CN201810613929 A CN 201810613929A CN 108403983 A CN108403983 A CN 108403983A
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rhizoma
radix
pueraria lobata
cerebral infarction
time
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CN108403983B (en
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刘秋艳
辛桉燃
张成儒
邓重启
邓靖
杨惠杰
李雪梅
张朝辉
辛宝民
邓蔚
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Abstract

The present invention relates to the stagnation resolvation Cyclandelates for the treatment of cerebral infarction sequela, the treatment medication of cerebral infarction sequela and at low cost, eutherapeutic problem can be effectively solved, by weight meter:55 65g of ginseng,280 320g of Radix Astragali,280 320g of grass-leaved sweetflag,130 170g of earthworm,130 170g of ground bettle,130 170g of Rhizoma Chuanxiong,130 170g of Radix Salviae Miltiorrhizae,130 170g of stir-baked SEMEN PERSICAE,90 110g of safflower,130 170g of radix paeoniae rubra,370 430g of pueraria lobata,110 130g of tabasheer,110 130g of Rhizoma Arisaematis (processed),Raw 130 170g of rhizoma typhonii is He 280 320g of Common St.Paulswort Herb is made,Abundant raw material of the present invention,Preparation method is simple,It is easy to produce,It is at low cost,It is convenient to take,Good effect,With inrigorating qi and promoting blood circulation,Disperse blood stasis and dredge collateral,The effect of waking up the patient from unconsciousness by clearing away phlegm,Efficiently solve the problems, such as cerebral infarction sequelae patient treatment medication for a long time,There is significant economic and social benefit.

Description

Treat the stagnation resolvation Cyclandelate of cerebral infarction sequela
Technical field
The present invention relates to medicine, especially a kind of stagnation resolvation Cyclandelate for treating cerebral infarction sequela(The also known as anti-bolt of stagnation resolvation Spirit).
Background technology
Cerebral infarction is current one of the three big diseases for threatening human health, and incidence is high, and disability rate is high, and the death rate is high, sternly The health and life security of the middle-aged and the old are threatened again.After Cerebral Infarction Treatment, though having kept life, lost after often leaving Disease is referred to as cerebral infarction sequela, and stroke patient occupies significant proportion, and clinical manifestation is after cerebral infarction is fallen ill 1 year, if also There are the symptoms such as hemiplegia or aphasis or facial paralysis, are just called cerebral infarction sequelae, after which is also referred to as cerebral infarction The disease phase is lost, compared with convalescence, resume speed and degree are slower.Cerebral infarction sequelae mainly has hemiplegia(Hemiplegia), half side limb Body obstacle, extremity numbness, hemianopsia, aphasia, extremity numbness, language caused by highly viscous mass formed by blood stasis, artery sclerosis, apoplexy, coronary heart disease etc. Say unfavorable, hemiplegia, vascular dementia, palpitaition, pectoralgia, uncomfortable in chest etc..Drastically influence the health and life peace of patient Entirely.
Although there are a variety of drugs for the treatment of cerebral infarction sequela at present, for various reasons, use and unsatisfactory, These Case treatment recovery times are long, many patients because occur the digestive tract reactions such as gastral cavilty turgor, anorexia or some because Decoction of medicinal ingredients economic expenditure is larger, it is difficult to bear, or decocting herb is disliked to bother the reasons such as bothersome, affect continuity and the treatment for the treatment of Effect.Therefore, the treatment medication for how effectively solving cerebral infarction sequela patient is the technical issues of needing conscientiously to solve.
Invention content
For the above situation, to overcome the defect of the prior art, the purpose of the present invention, which is just to provide, a kind for the treatment of cerebral infarction The stagnation resolvation Cyclandelate of sequelae can effectively solve the treatment medication of cerebral infarction sequela and at low cost, eutherapeutic problem.
The technical solution that the present invention solves is, cerebral infarction sequela be mostly because of insufficiency of vital energy and blood, phlegm-blood stasis, blockage of main and collateral channels and draw It rises, therefore, when treatment should be with inrigorating qi and promoting blood circulation, and disperse blood stasis and dredge collateral, waking up the patient from unconsciousness by clearing away phlegm is the rules for the treatment of, and accordingly, the present invention loses after treating cerebral infarction The technical solution that the stagnation resolvation Cyclandelate of disease solves is, by weight meter:Ginseng 55-65g, Radix Astragali 280-320g, grass-leaved sweetflag 280- It is 320g, earthworm 130-170g, ground bettle 130-170g, Rhizoma Chuanxiong 130-170g, Radix Salviae Miltiorrhizae 130-170g, stir-baked SEMEN PERSICAE 130-170g, red Flower 90-110g, radix paeoniae rubra 130-170g, pueraria lobata 370-430g, tabasheer 110-130g, Rhizoma Arisaematis (processed) 110-130g, raw rhizoma typhonii 130-170g and Common St.Paulswort Herb 280-320g are made, wherein crush ginseng, grass-leaved sweetflag, earthworm, ground bettle, Rhizoma Chuanxiong and 1/2 pueraria lobata At the fine powder for crossing 80-100 mesh sieve;Again by remaining pueraria lobata and Radix Astragali, Common St.Paulswort Herb, rhizoma typhonii, peach kernel, safflower, tabasheer, Tian Nan Star, Radix Salviae Miltiorrhizae, radix paeoniae rubra add water to submerge decoction three times every time, 1.5 hours for the first time, and each 1 hour of second and third time merges decocting liquid three times, Filtration, filtrate are concentrated into the thick paste that 80 DEG C of relative density is 1.30~1.35;By fine powder and thick paste mixing, pill, low temperature drying, Polishing to get.
Abundant raw material of the present invention, preparation method is simple, easy to produce, at low cost, convenient to take, good effect, and there is tonifying Qi to live The effect of blood, disperse blood stasis and dredge collateral, waking up the patient from unconsciousness by clearing away phlegm, efficiently solves the problems, such as cerebral infarction sequelae patient treatment medication for a long time, has significantly Economic and social benefit.
Specific implementation mode
It elaborates with reference to embodiments to the specific implementation mode of the present invention.
The present invention in specific implementation, can be provided by following embodiment.
Embodiment 1
The present invention in specific implementation, a kind of stagnation resolvation Cyclandelate for treating cerebral infarction sequela, by weight meter:Ginseng 58- 62g, Radix Astragali 285-315g, grass-leaved sweetflag 285-315g, earthworm 140-160g, ground bettle 140-160g, Rhizoma Chuanxiong 140-160g, Radix Salviae Miltiorrhizae 140-160g, stir-baked SEMEN PERSICAE 140-160g, safflower 95-105g, radix paeoniae rubra 140-160g, pueraria lobata 380-420g, tabasheer 115-125g, Rhizoma Arisaematis (processed) 115-125g, raw rhizoma typhonii 140-160g are He Common St.Paulswort Herb 285-315g is made, wherein by ginseng, grass-leaved sweetflag, Dragon, ground bettle, Rhizoma Chuanxiong and 1/2 pueraria lobata were ground into the fine powder of 80-100 mesh sieve;Again by remaining pueraria lobata and Radix Astragali, Common St.Paulswort Herbs, white Monkshood, peach kernel, safflower, tabasheer, rhizoma arisaematis, Radix Salviae Miltiorrhizae, radix paeoniae rubra add water to submerge decoction three times every time, 1.5 hours for the first time, the Two, three times each 1 hour, merge decocting liquid three times, filtration, filtrate is concentrated into the thick paste that 80 DEG C of relative density is 1.30~1.35;It will Fine powder and thick paste mixing, pill, low temperature drying, polishing to get.
Embodiment 2
The present invention in specific implementation, a kind of stagnation resolvation Cyclandelate for treating cerebral infarction sequela, by weight meter:Ginseng 60g, Huang Stilbene 300g, grass-leaved sweetflag 300g, earthworm 150g, ground bettle 150g, Rhizoma Chuanxiong 150g, Radix Salviae Miltiorrhizae 150g, stir-baked SEMEN PERSICAE 150g, safflower 100g, Radix paeoniae rubra 150g, pueraria lobata 400g, tabasheer 120g, Rhizoma Arisaematis (processed) 120g, raw rhizoma typhonii 150g are He Common St.Paulswort Herb 300g is made, wherein Ginseng, grass-leaved sweetflag, earthworm, ground bettle, Rhizoma Chuanxiong and 1/2 pueraria lobata were ground into the fine powder of 80-100 mesh sieve;Again by remaining pueraria lobata And Radix Astragali, Common St.Paulswort Herbs, rhizoma typhonii, peach kernel, safflower, tabasheer, rhizoma arisaematis, Radix Salviae Miltiorrhizae, radix paeoniae rubra add water to submerge decoction three times every time, the One time 1.5 hours, second and third time each 1 hour, merge decocting liquid three times, filtration, filtrate be concentrated into 80 DEG C of relative density for 1.30~ 1.35 thick paste;By fine powder and thick paste mixing, pill, low temperature drying, polishing to get.
Embodiment 3
The present invention in specific implementation, a kind of stagnation resolvation Cyclandelate for treating cerebral infarction sequela, by weight meter:Ginseng 60g, Huang It is stilbene 310g, grass-leaved sweetflag 290g, earthworm 160g, ground bettle 140g, Rhizoma Chuanxiong 160g, Radix Salviae Miltiorrhizae 140g, stir-baked SEMEN PERSICAE 160g, safflower 92g, red Chinese herbaceous peony 160g, pueraria lobata 380g, tabasheer 120g, Rhizoma Arisaematis (processed) 115g, raw rhizoma typhonii 160g are He Common St.Paulswort Herb 290g is made, wherein will Ginseng, grass-leaved sweetflag, earthworm, ground bettle, Rhizoma Chuanxiong and 1/2 pueraria lobata were ground into the fine powder of 80-100 mesh sieve;Again by remaining pueraria lobata and Radix Astragali, Common St.Paulswort Herbs, rhizoma typhonii, peach kernel, safflower, tabasheer, rhizoma arisaematis, Radix Salviae Miltiorrhizae, radix paeoniae rubra add water to submerge decoction three times every time, and first Secondary 1.5 hours, second and third time each 1 hour, merge decocting liquid three times, filtration, filtrate be concentrated into 80 DEG C of relative density for 1.30~ 1.35 thick paste;By fine powder and thick paste mixing, pill, low temperature drying, polishing to get.
In said medicine, ginseng, Radix Astragali QI invigorating are monarch drug in a prescription, earthworm, ground bettle, Rhizoma Chuanxiong, peach kernel, safflower, Radix Salviae Miltiorrhizae, radix paeoniae rubra Promoting blood circulation and removing obstruction in channels is ministerial drug, and grass-leaved sweetflag, raw rhizoma typhonii, tabasheer, rhizoma arisaematis dissipating phlegm for resuscitation are adjutant, and uncommon Xian grass, pueraria lobata wind-dispelling are logical Network is to make medicine.All medicines share amounts to qi and activate blood circulation, dispelling wind and removing obstruction in the meridians, the function of dissipating phlegm for resuscitation, effective for being lost after treatment cerebral infarction Disease, including hemiplegia(Hemiplegia), half side physical handicaps, extremity numbness, hemianopsia, aphasia, highly viscous mass formed by blood stasis, artery sclerosis, in Extremity numbness, dysphonia, hemiplegia, vascular dementia, palpitaition, pectoralgia, uncomfortable in chest etc. caused by wind, coronary heart disease etc..And it passes through Experiment and clinical application, achieve extraordinary advantageous effects, and related testing data is as follows:
One, the standard of case is selected
It is all with after cerebral infarction, there is hemiplegia(Hemiplegia), half side physical handicaps, extremity numbness, hemianopsia, aphasia, it is highly viscous Extremity numbness caused by mass formed by blood stasis, artery sclerosis, apoplexy, coronary heart disease etc., dysphonia, hemiplegia, vascular dementia, palpitaition, Pectoralgia, uncomfortable in chest etc. can be used as the standard of selection case.
Two, diagnostic criteria
After suffering from cerebral infarction, there is hemiplegia(Hemiplegia), half side physical handicaps, extremity numbness, hemianopsia, aphasia, highly viscous blood Extremity numbness, dysphonia, hemiplegia, vascular dementia, palpitaition, chest caused by disease, artery sclerosis, apoplexy, coronary heart disease etc. Bitterly, the symptoms such as uncomfortable in chest, and diagnosed through brain CT examination, you can it makes a definite diagnosis with cerebral infarction sequela.
Three, therapeutic scheme
The cerebral infarction sequela patient made a definite diagnosis is treated using traditional Chinese medicine pill of the present invention, is taken orally, 2 times every time, each 6g, after meal It takes, 1 month as a treatment course, and curative effect is counted after 2 courses for the treatment of.During treatment, the merging such as hypertension, diabetes are strictly controlled Disease, and reinforce physical rehabilitation exercise.
Four, efficacy assessment standard
According to Tai'an meeting in 1986《Stroke Chinese Medicine diagnosis, efficacy assessment standard》It is divided into Pyatyi.(One)It is almost recovered:Integral Up to 24 points or more persons(I.e. symptom disappears substantially, and life is normal).(Two)It is effective:Integral increases above 10 points of persons(Symptom has significantly Improve, quality of life increases).(Three)Effectively:Integral increases above 4 points of persons(Symptom is mitigated, and quality of life is changed It is kind).(Four)In vain:Integral increases less than 4 persons of dividing(Symptom is not obviously improved, but is not also deteriorated further).(Five)Deteriorate: Aggravation or died.
Five, statistical procedures
Through being treated to 30 people of cerebral infarction sequela patient made a definite diagnosis, wherein 18 people of male, 12 people of women, the oldest 79 It is year, 46 years old minimum, it is 59 years old average;The course of disease is most 7 days short, longest 30 days, 18 days average;All cases are made a definite diagnosis through brain CT.Wherein Cerebral thrombosis 6, cerebral embolism 2, lacunar infarction 22, complicated hypertension 19, diabetes 8,2, the wind heart.
It by above-mentioned therapeutic scheme, is treated using traditional Chinese medicine pill of the present invention, statistical procedures result:It is almost recovered 11, Account for 36.7%;Effective 13, account for 43.3%;Effective 4, account for 13.3%;Invalid 2, account for 6.7%;Deteriorate 0.Total effective rate 93.3%。
Six, model case
1, Lee, man 56 years old, trike right hemiplegia, aphasia before half a month, and brain CT shows " lacunar infarction ", through infusion Treatment, stabilization are examined later.Card is shown in:Right hemiplegia, speech undercurrent profit, complexion is grey floating, and sound is low, dark tongue quality, and tongue is white thick greasy.It gives Stagnation resolvation Cyclandelate of the present invention, one time 6 grams, 2 times a day, spirit improves after half a month, and right side limbs vigor has improvement.Medication February Remaining, right side limb function obviously improves, and takes care of oneself.
2, Liu, female 65 years old, are chief complaint and are admitted to hospital with " aphasia, unfavorable 1 day of left limb activity ", card of being admitted to hospital is shown in: Mind is clear, and spirit is poor, and headache, aphasia, left limb activity is unfavorable, and cough of choking of drinking water, irritated, nausea, food of receiving is not good enough, sleep Difference, stool is dry, a line on the 2nd, indwelling catheter.Physical examination:Purplish tongue, white thick greasy, the intermittent pulse of tongue.Neurological examination:Speech is not Profit, bicker right avertence, loll left avertence, has no lingualis atrophy and fasciculation.0 grade of left limb upper and lower extremities muscular strength, muscular hypotonus. 5 grades of upper right myodynamia, Muscle tensility is normal.Superficial reflex:Abdominal reflexes are normal, and limbs superficial sensibility is normal, deep reflex:The bilateral upper arm two Head flesh, triceps muscle of arm tendon reflex, bilateral knee jerk, Achilles jerk are symmetrically without hyperfunction, left babinski's sign(+), palm-chin reflex (+).Meningeal irritation sign:It is negative.Auxiliary examination:Head CT is unenhanced to be shown:Right hemisphere and left side hemisphaerium cerebelli low-density shadow, Consider that multiple cerebral infarction, part softening stove are formed, arteria basilaris atherosis.Previously:Atrial fibrillation medical history 13 years.Giving The anti-bolt spirit of the stasis of blood is oral, one time 6 grams, 2 times a day.After half a month, patient's mind is clear, spirit can, speech is clear earlier above, and drinking-water cough of choking is bright Aobvious to improve, bicker right avertence, loll left avertence, has no lingualis atrophy and fasciculation.3 grades of left limb muscular strength, muscular hypotonus.It is right 5 grades of upper limb body flesh, Muscle tensility is normal.After 2 months.Patient's mind is clear, spiritual good, artistomia, and no drinking-water is choked cough, left limb flesh 4 grades of strong, muscular hypotonus of power.5 grades of upper right limbs flesh, Muscle tensility is normal.It takes care of oneself.
3, health so-and-so, female, 68 years old, with " it is dizzy, left limb is 4 days powerless, aggravate to choke cough 1 day with drinking-water." be chief complaint into Institute.Be admitted to hospital symptoms include:Mind is clear, and spirit is poor, dizzy, muddled, blurred vision, and cough of choking of drinking water, left limb is numb powerless, have palpitation, Uncomfortable in chest, slow in reacting, decrease of memory receives difference, and it is poor that night sleeps, and stool does, is small.Dimly red tongue, tongue is white, veins string.Physical examination: BP:178/89mmHg, neurological examination:Dextro manuality, memory and calculating power decline, positioning, capacity of orientation are fine, comprehension Still.Aphasia.Dicoria etc. waits greatly circle, pupil diameter about 3mm sensitive to light reflection.Bilateral volume line is symmetrical, and bicker is right Partially, loll left avertence, and the non-atrophy of lingualis has no fasciculation.2 grades of left upper extremity, lower-limb muscular strength, muscular hypotonus, the upper and lower limb in right side 5 grades of muscular strength, Muscle tensility is normal.Examination of coordinate movement can not be completed, and the depth feels left side decline, and right side is shown no obvious abnormalities.It is right Side Hoffmann sign and Babinski sign(+).Neck is soft, passivity, meningeal irritation sign(-).Auxiliary examination:Head B-sonography+MRA:1. carrying Show the subacute early stage cerebral infarction of the right part of brain stem;2. multiple white matter of brain disentwining angle velocity;3. slight encephalatrophy;4. brain MRA shows that brain is dynamic Arteries and veins hardens;Section tube chamber many places right side arteria cerebri posterior P1, P3 are narrow.Previously:Hypertension history 20 years, maximal blood pressure 200/ 100mmHg;Coronary heart disease, unstable angina medical history 5 years.It is oral to give the anti-bolt spirit of stagnation resolvation, one time 6 grams, 2 times a day.Half a month Afterwards, patient's mind is clear, spirit can, speech is clear earlier above, and drinking-water cough of choking is clearly better, and bicker right avertence, loll left avertence, has no lingualis Atrophy and fasciculation.3 grades of left limb muscular strength, muscular hypotonus.5 grades of upper right limbs flesh, Muscle tensility is normal.After 2 months.Patient Mind is clear, spiritual good, artistomia, and no drinking-water is choked cough, and left side upper limb proximal end muscular strength is 4 grades strong, and 4 grades of distal end muscular strength, Muscle tensility is slightly By force.5 grades of right side upper and lower extremities muscular strength, Muscle tensility is normal.It takes care of oneself.
Seven, conclusion
Clinical practice treatment observation for many years proves that apoplexy is the card of asthenia in origin and asthenia in superficiality, is originally insufficiency of primordial QI, liver-kidney deficiency;Mark It is wind, phlegm, stagnation of blood stasis, especially in convalescence, wind, phlegm, hemostasis flee channels and collaterals, and the resistance of blood vessels numbness, through then obstructed, gas cannot Row, blood cannot moisten, and show as that limbs are weak and feeble etc., and it is treatment original preferably use inrigorating qi and promoting blood circulation, disperse blood stasis and dredge collateral, waking up the patient from unconsciousness by clearing away phlegm more Then, therefore, according to the principles of formulating prescriptions of Chinese pharmacology principle and monarch, the traditional Chinese medicinal components and dosage provided using the present invention are all The effect of medicine shares, and amounts to inrigorating qi and promoting blood circulation, disperse blood stasis and dredge collateral, waking up the patient from unconsciousness by clearing away phlegm, effective for including hemiplegia caused by cerebral infarction(Half body It is unsuccessful), half side physical handicaps, extremity numbness, hemianopsia, aphasia, caused by highly viscous mass formed by blood stasis, artery sclerosis, apoplexy, coronary heart disease etc. The sequelae such as extremity numbness, dysphonia, hemiplegia, vascular dementia, palpitaition, pectoralgia, uncomfortable in chest, convenient to take, good effect, Curative effect is up to 93% or more, and drug safety can take for long periods of time, have no adverse reaction, and is the wound treated on cerebral infarction sequela drug Newly, there is significant economic and social benefit.

Claims (4)

1. a kind of stagnation resolvation Cyclandelate for treating cerebral infarction sequela, which is characterized in that by weight meter:Ginseng 55-65g, Radix Astragali 280-320g, grass-leaved sweetflag 280-320g, earthworm 130-170g, ground bettle 130-170g, Rhizoma Chuanxiong 130-170g, Radix Salviae Miltiorrhizae 130- 170g, stir-baked SEMEN PERSICAE 130-170g, safflower 90-110g, radix paeoniae rubra 130-170g, pueraria lobata 370-430g, tabasheer 110-130g, day processed Southern Star 110-130g, raw rhizoma typhonii 130-170g are He Common St.Paulswort Herb 280-320g is made, wherein by ginseng, grass-leaved sweetflag, earthworm, soil Soft-shelled turtle worm, Rhizoma Chuanxiong and 1/2 pueraria lobata were ground into the fine powder of 80-100 mesh sieve;Again by remaining pueraria lobata and Radix Astragali, Common St.Paulswort Herbs, rhizoma typhonii, Peach kernel, safflower, tabasheer, rhizoma arisaematis, Radix Salviae Miltiorrhizae, radix paeoniae rubra add water to submerge decoction three times every time, 1.5 hours for the first time, second and third time Each 1 hour, merge decocting liquid three times, filtration, filtrate is concentrated into the thick paste that 80 DEG C of relative density is 1.30~1.35;By fine powder and thick Cream mixing, pill, low temperature drying, polishing to get.
2. the stagnation resolvation Cyclandelate for the treatment of cerebral infarction sequela according to claim 1, which is characterized in that by weight meter: Ginseng 58-62g, Radix Astragali 285-315g, grass-leaved sweetflag 285-315g, earthworm 140-160g, ground bettle 140-160g, Rhizoma Chuanxiong 140- 160g, Radix Salviae Miltiorrhizae 140-160g, stir-baked SEMEN PERSICAE 140-160g, safflower 95-105g, radix paeoniae rubra 140-160g, pueraria lobata 380-420g, tabasheer 115-125g, Rhizoma Arisaematis (processed) 115-125g, raw rhizoma typhonii 140-160g are He Common St.Paulswort Herb 285-315g is made, wherein by ginseng, stone Calamus, earthworm, ground bettle, Rhizoma Chuanxiong and 1/2 pueraria lobata were ground into the fine powder of 80-100 mesh sieve;Again by remaining pueraria lobata and Radix Astragali, pig Xian grass, rhizoma typhonii, peach kernel, safflower, tabasheer, rhizoma arisaematis, Radix Salviae Miltiorrhizae, radix paeoniae rubra add water to submerge decoction three times every time, and 1.5 is small for the first time When, second and third time each 1 hour, merge decocting liquid three times, filtration, filtrate be concentrated into 80 DEG C of relative density for 1.30~1.35 it is thick Cream;By fine powder and thick paste mixing, pill, low temperature drying, polishing to get.
3. the stagnation resolvation Cyclandelate for the treatment of cerebral infarction sequela according to claim 1, which is characterized in that by weight meter: Ginseng 60g, Radix Astragali 300g, grass-leaved sweetflag 300g, earthworm 150g, ground bettle 150g, Rhizoma Chuanxiong 150g, Radix Salviae Miltiorrhizae 150g, stir-baked SEMEN PERSICAE 150g, Safflower 100g, radix paeoniae rubra 150g, pueraria lobata 400g, tabasheer 120g, Rhizoma Arisaematis (processed) 120g, raw rhizoma typhonii 150g are He Common St.Paulswort Herb 300g systems At, wherein ginseng, grass-leaved sweetflag, earthworm, ground bettle, Rhizoma Chuanxiong and 1/2 pueraria lobata were ground into the fine powder of 80-100 mesh sieve;Again will Remaining pueraria lobata and Radix Astragali, Common St.Paulswort Herbs, rhizoma typhonii, peach kernel, safflower, tabasheer, rhizoma arisaematis, Radix Salviae Miltiorrhizae, radix paeoniae rubra add water to submerge pan-fried every time It boils three times, 1.5 hours for the first time, each 1 hour of second and third time merges decocting liquid three times, filtration, and filtrate is concentrated into relative density 80 DEG C be 1.30~1.35 thick paste;By fine powder and thick paste mixing, pill, low temperature drying, polishing to get.
4. the stagnation resolvation Cyclandelate for the treatment of cerebral infarction sequela according to claim 1, which is characterized in that by weight meter: Ginseng 60g, Radix Astragali 310g, grass-leaved sweetflag 290g, earthworm 160g, ground bettle 140g, Rhizoma Chuanxiong 160g, Radix Salviae Miltiorrhizae 140g, stir-baked SEMEN PERSICAE 160g, Safflower 92g, radix paeoniae rubra 160g, pueraria lobata 380g, tabasheer 120g, Rhizoma Arisaematis (processed) 115g, raw rhizoma typhonii 160g are He Common St.Paulswort Herb 290g systems At, wherein ginseng, grass-leaved sweetflag, earthworm, ground bettle, Rhizoma Chuanxiong and 1/2 pueraria lobata were ground into the fine powder of 80-100 mesh sieve;Again will Remaining pueraria lobata and Radix Astragali, Common St.Paulswort Herbs, rhizoma typhonii, peach kernel, safflower, tabasheer, rhizoma arisaematis, Radix Salviae Miltiorrhizae, radix paeoniae rubra add water to submerge pan-fried every time It boils three times, 1.5 hours for the first time, each 1 hour of second and third time merges decocting liquid three times, filtration, and filtrate is concentrated into relative density 80 DEG C be 1.30~1.35 thick paste;By fine powder and thick paste mixing, pill, low temperature drying, polishing to get.
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115518140A (en) * 2022-10-22 2022-12-27 王可兴 Traditional Chinese medicine composition for treating apoplexy sequela and preparation method thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101612274A (en) * 2008-06-27 2009-12-30 赵爱红 A kind of health promoting decoction for the treatment of myocardial infarction
CN102512521A (en) * 2011-12-16 2012-06-27 商洛学院 Traditional Chinese medicine composition for treating apoplexy sequela
CN107115428A (en) * 2017-05-15 2017-09-01 玉林市中医医院 It is a kind of to treat Chinese medicine composition of apoplexy and preparation method thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101612274A (en) * 2008-06-27 2009-12-30 赵爱红 A kind of health promoting decoction for the treatment of myocardial infarction
CN102512521A (en) * 2011-12-16 2012-06-27 商洛学院 Traditional Chinese medicine composition for treating apoplexy sequela
CN107115428A (en) * 2017-05-15 2017-09-01 玉林市中医医院 It is a kind of to treat Chinese medicine composition of apoplexy and preparation method thereof

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
刘典功: "《中.日名老中(汉)医临床谴方心得荟萃》", 28 February 2011, 科学技术文献出版社 *
周晓慧: "补阳还五汤加减治疗中风后遗症临床观察", 《中医临床研究》 *
朱昌华: "基于数据挖掘的中风后遗症方药运用规律研究", 《中国优秀硕士学位论文全文数据库医药卫生科技辑》 *
王爱雨: "补阳还五汤加减治疗中风后遗症", 《山东中医杂志》 *
董征亮: "补阳还五汤及其加减方治疗脑梗死的临床研究进展", 《中国当代医药》 *
董秀文: "《当代心脑肾肝胆病医方集成》", 30 September 2002, 中国医药科技出版社 *
陈大舜: "《最好的中医名著公开课:名师解读历代名医临床必读医论》", 31 August 2014, 湖南科学技术出版社 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115518140A (en) * 2022-10-22 2022-12-27 王可兴 Traditional Chinese medicine composition for treating apoplexy sequela and preparation method thereof

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