CN103386090B - Miao medicine for treating neurasthenia, and preparation method thereof - Google Patents
Miao medicine for treating neurasthenia, and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a Miao medicine for treating neurasthenia. The Miao medicine comprises the following medicinal materials in parts by mass: 20-25 parts of radix polygoni multiflori, 20-25 parts of polygala tenuifolia, 30-35 parts of lily, 15-20 parts of tuber fleeceflower stem,15-20 parts of concha haliotidis, 10-15 parts of cortex cinnamomi, 10-15 parts of radix scrophulariae, 20-25 parts of dried rehmannia root, 15-20 parts of radix curcumae, 10-15 parts of rhizoma coptidis, 10-15 parts of safflowers, 20-25 parts of angelica sinensis, and 20-25 parts of selfheal spike. A preparation method of the Miao medicine comprises the steps of processing the radix polygoni multiflori to form prepared radix polygoni multiflori; cleaning and drying other medicinal materials, drying, and crushing the prepared radix polygoni multiflori and the dried medicinal materials; disinfecting, mixing according to the formula proportion, adding water for steeping, introducing steam for heating, and extracting effective components from the medicinal materials; filtering to prepare an extract; drying, crushing, grinding the extract into powder, and evenly mixing; and finally tabletting the mixture powder or filling the mixture powder into capsules to obtain the Miao medicine. The Miao medicine has the effects of calming the liver, suppressing yang, nourishing yin to lessen fire, and tranquilizing by nourishing the heart, and is obvious in curative effect, and applicable to treating patients with nervous prostration.
Description
Technical field
The present invention is relevant with medicinal preparation, in particular to the neurasthenic medicine for the treatment of, also relates to the preparation method of this medicine.
Background technology
Neurasthenia refers to that brain is due to long-term nervous and stress, thus produce weakening of ergasia ability, its principal character is spirit easily excitement and mental fatiguability, sleep disorder, hypomnesis, headache etc., with symptoms such as various Somatic discomfort.The course of disease is delayed, heavy time light during symptom, and state of an illness fluctuation is normal relevant with socio-psychological factors.Most of case fall ill in 16-40 year between, both sexes morbidity number no significant difference.The person of being engaged in mental work occupies the majority.Even primary disease can be delayed as dealt with improperly reach several years many decades.As new Nervous and Mental Factors or deficiency of having a rest, symptom can be reappeared or aggravate.
In recent years, treat neurasthenic Chinese patent application part with Chinese medicinal herbs and increase very fast, application part nearly up to a hundred, recent years, applications increased severely.According to incompletely statistics, within 2004, there are 3, within 2005, have 6, within 2006, have 6, within 2007, have 10, within 2008, have 16, within 2009, have 13, within 2010, be increased to 14, within 2011, have 11, within 2012, be increased to 19.Nearest application part has: No. 201310054109.9 " one treats neurasthenic Chinese medicine composition ", No. 201310052482.0 " one treats neurasthenic Chinese medicine preparation ", No. 201310108405.2 " one treats neurasthenic medicament ", No. 201310027379.0 " a kind of coordinating YIN and YANG, benefiting vital QI for tranquillizing, for neurasthenic medicine and preparation method thereof " and No. 201310080438.0 " one treats neurasthenic pharmaceutical preparation " etc.These patent applications all disclose the neurasthenic Chinese herbal medicine for the treatment of, but its curative effect there is no report.Therefore people are still at exploitation renewal, more effective medicine.
Summary of the invention
Object of the present invention is just to provide a kind of Miao Ethnomedicine for the treatment of neurasthenia, to increase the types of drugs for the treatment of neurasthenia, enables the health service into people.
Another object of the present invention is to provide the preparation method of this Miao Ethnomedicine.
The Miao Ethnomedicine for the treatment of neurasthenia of the present invention is made up of the medical material of following quality proportioning:
The Radix Polygoni Multiflori 20 ~ 25, Radix Polygalae 20 ~ 25, Bulbus Lilii 30 ~ 35, Caulis Polygoni Multiflori 15 ~ 20, Concha Haliotidis 15 ~ 20, Cortex Cinnamomi 10 ~ 15, Radix Scrophulariae 10 ~ 15, Radix Rehmanniae 20 ~ 25, Radix Curcumae 15 ~ 20, Rhizoma Coptidis 10 ~ 15, Flos Carthami 10 ~ 15, Radix Angelicae Sinensis 20 ~ 25, Spica Prunellae 20 ~ 25;
Wherein the Radix Polygoni Multiflori must be concocted in advance.
In above-mentioned medical material:
the Radix Polygoni Multiflorifor polygonum multiflorum thunb (
polygonum multiflorum) tuber, sweet-puckery flavor, slightly warm in nature, can tonifying liver, kidney tonifying, nourish blood, dispel the wind (compiling " Chinese medicine voluminous dictionary " 1135 pages see the new medical college in Jiangsu);
radix Polygalaefor milk wort Roots of Polygala tenuifolia (
polygala tenuifolia) root, warm in nature, acrid in the mouth is bitter, Fructus Alpiniae Oxyphyllae of calming the nerves, eliminate the phlegm, resolving depression (see " Chinese medicine voluminous dictionary " 1028 pages);
bulbus Lilii, for liliaceous plant Bulbus Lilii (
lilium brownii) scale leaf of bulb, sweet and slightly bitter taste, property is put down, and has the effect (see " Chinese medicine voluminous dictionary " 856 pages) of nourishing the lung to arrest cough, clearing away heart-fire for tranquillization;
caulis Polygoni Multiflorifor polygonum multiflorum thunb (
polygonum multiflorum) rattan or leaf bine stem, sweet and slightly bitter taste, property is put down, and tranquilizing by nourishing the heart, dredging collateral can dispel the wind (see " Chinese medicine voluminous dictionary " 1443 pages);
semen Cassiae, for leguminous plant Semen Cassiae (
cassia tora) mature seed, bitter but sweet flavor, cool in nature, can liver heat removing, improving eyesight, diuretic, relieving constipation (see " Chinese medicine voluminous dictionary " 949 pages);
cortex Cinnamomi, for canella Cortex Cinnamomi (
cinnamomum cassia) dried bark and branch skin, acrid-sweet flavor, hot in nature, can complement sun, warming the spleen and stomach, removing accumulated cold, promoting blood circulation (see " Chinese medicine voluminous dictionary " 890 pages);
radix Scrophulariaefor goatweed Radix Scrophulariae (
scrophularia ningpoensis) root, bitter in the mouth is salty, cool in nature, has the effect (see " Chinese medicine voluminous dictionary " 769 pages) of YIN nourishing, pathogenic fire reducing, relieving restlessness, removing toxic substances;
radix Rehmanniaefor scrophulariaceae rehmannia glutinosa plant (
rehmannia glutinosa) fresh rhizome, sweet-bitter flavor, cold in nature, have heat clearing away, removing heat from blood, effect of promoting the production of body fluid (see " Chinese medicine voluminous dictionary " 2568 pages);
radix Curcumaefor zingiberaceous plant Radix Curcumae (
curcuma arom) tuber, acrid in the mouth is bitter, cool in nature, can promoting QI circulation for relieving depression, removing heat from blood removing blood stasis with potent drugs (see " Chinese medicine voluminous dictionary " 1316 pages);
rhizoma Coptidisfor ranunculaceae plant Rhizoma Coptidis (
coptis chinensis) rhizome, bitter in the mouth, cold in nature, have pathogenic fire purging, dampness, effect (compiling " Chinese medicine voluminous dictionary " 2022 pages see the new medical college in Jiangsu) of removing toxic substances, parasite killing;
flos Carthami, for irides Stigma Croci (
crocus sativus) top of style and stigma, sweet in the mouth, property is put down, can blood circulation promoting and blood stasis dispelling, dispersing stagnation and relieving accumulation of pathogens (see " Chinese medicine voluminous dictionary " 2671 pages);
radix Angelicae Sinensis,for umbelliferae angelica (
angelica sinensis) root, sweet in the mouth is pungent, warm in nature, has benefiting blood and regulating blood circulation, menstruction regulating and pain relieving, moisturizes the effect of laxation, can control menoxenia, headache due to deficiency of blood, dizzy, numbness of withering (see " Chinese medicine voluminous dictionary " 876 pages);
spica Prunellaefor labiate Spica Prunellae
(Prunella vuigaris) herb, acrid in the mouth is bitter, cold in nature, can liver heat removing heat radiation (see " Chinese medicine voluminous dictionary " 1827 pages).
Above-mentioned medical material should meet the regulation in " Chinese Pharmacopoeia " nineteen ninety-five version one under each medical material item.
The preparation method of the neurasthenic Miao Ethnomedicine of the treatment that inventor provides first conventionally is concocted by the Radix Polygoni Multiflori as Radix Polygoni Multiflori Preparata, for subsequent use; Again all the other 12 taste medical materials are cleaned respectively, with hot-air seasoning, be processed into fragment together with Radix Polygoni Multiflori Preparata; With disinfection by ultraviolet light, after formula proportion mixing, put into the pond that pottery or copper tank or wooden barrel or cement be built into and add water retting, and pass into steam 3 heating, till wherein active ingredient proposes substantially; Extractum is made in filtration; Fire drying in using again, pulverizes, grinds to form 60 order powder, mix homogeneously; Last pharmaceutical technology routinely, is pressed into tablet or incapsulates, and every 1g or every sheet 1g, obtains tablet or capsule.
The above-mentioned pharmaceutical technology being pressed into tablet comprises: 1. 60 obtained order powder are added adjuvant, main adjuvant is adhesive modified starch, mix homogeneously; 2. add water in mixed powder as wetting agent, make soft material; 3. soft material extruding is sieved, make granule; 4. granule is through super-dry, make its moisture be applicable to and evenly, grain graininess is suitable; 5. dried particles is through inspection, confirms the requirement meeting tablet; 6. extrude tablet with Chong Yashi or rotary tablet machine, what be up to the standards is finished product.
The pharmaceutical technology of above-mentioned capsule comprises: 1. preparing or buying with gelatin is the capsulae vacuus of primary raw material; 2. 60 obtained order powder are crossed No. 6 sieves, the fine powder obtained is for subsequent use; 3. enter soft capsule with artificial medicated powder of loading, or load medicated powder with automatic filling machine; 4. test to the effective ingredient of medicated powder and quality, the glue of qualified rear gelatin, in the sealing of capsule capping place, obtains finished product.
Inventor points out: this Miao Ethnomedicine also can be prepared into any one by conventional method of Chinese medicinal and commonly use peroral dosage form.No matter which kind of dosage form, all must deposit according to the relevant regulations of drug stock control.
Treatment of the present invention neurasthenic Miao Ethnomedicine using method is oral, warm water delivery service, every day 2 times, each 4 ~ 5/sheet.
The Miao Ethnomedicine for the treatment of neurasthenia of the present invention is used for accepting neurastheniac 37 people for medical treatment, wherein male 17 people, women 20 people, case history is many more than 2 years, within 2 years, thinks 11 people, and 30 ~ 60 days persons that take medicine are 27 people, more than 60 ~ 100 days persons that take medicine are 10 people, healing person 27 people, responder is 5 people, nonresponder 5 people.Model case has:
Case one: Nie Cui, female, 47 years old, Ya Chi people from town, Bijie City, Guizhou Province.Patient started dizzy insomnia in 2003, and 2004 start to increase the weight of, and can only sleep 2-3 hour every night, and with dreaminess, after getting up morning, feel fatigue, yellow urine, yellow fur, confirm as neurasthenia through Duo Jia hospital, once multiple Chinese medicine and western medicine was taken, poor effect, after being introduced, take medicine of the present invention 30 days, spirit takes a turn for the better, and time for falling asleep extends, serve on 40 days, all diseases are all removed, and sleep is better, as normal person.
Case two: Liu Baogui, man, 37 years old, Guizhou Province's Bijie hospital personnel.Patient feels vexed, forgetful, uncomfortable in chest, poor sleep from January, 2008, is diagnosed as neurasthenia through hospital, and through taking medicine of the present invention one month, disease takes a turn for the better to some extent, serve on two months, and all diseases of patient are healed entirely.
Case three: Pan Aiping, female, 39 years old.Patient started from 2005, had dizziness, insomnia, and with sore waist and aching in the waist and the back, thirsty with bitter taste, total urination time is many, constipation with dry stool, once the Chinese medicine such as chlorphenamine and chlorpromazine was taken, poor effect, upon somebody's introduction, take this use invention medicine, two months 10 days, can sleep peacefully, diet increases, spirit expires, and all diseases are eliminated, as normal person.
The Miao Ethnomedicine for the treatment of neurasthenia of the present invention has suppressing the hyperactive liver and subsiding YANG, nourishing YIN to lower pathogenic fire, tranquilizing by nourishing the heart effect, and curative effect is obvious, is applicable to the patient treating neurasthenia.
Detailed description of the invention
Embodiment is according to the neurasthenic Miao Ethnomedicine of the following step preparation treatment:
First the Radix Polygoni Multiflori is conventionally concocted into Radix Polygoni Multiflori Preparata, for subsequent use; Again all the other 12 taste medical materials are cleaned respectively, with hot-air seasoning, be processed into fragment together with Radix Polygoni Multiflori Preparata; With disinfection by ultraviolet light, get Radix Polygoni Multiflori Preparata 22g, Radix Polygalae 22g, Bulbus Lilii 32g, Caulis Polygoni Multiflori 18g, Concha Haliotidis 18g, Cortex Cinnamomi 14g, Radix Scrophulariae 12g, Radix Rehmanniae 22g, Radix Curcumae 18g, Rhizoma Coptidis 13g, Flos Carthami 13g, Radix Angelicae Sinensis 22g, Spica Prunellae 22g; After mixing, put into wooden barrel and add water retting, and pass into steam 3 heating, determine that wherein active ingredient proposes substantially after chemical examination till; Extractum is made in filtration; Fire drying in using again, pulverizes, grinds to form 60 order powder, mix homogeneously; Last pharmaceutical technology routinely, is pressed into tablet or incapsulates, and every 1g or every sheet 1g, obtains tablet or capsule.
Claims (1)
1. treat a Miao Ethnomedicine for neurasthenia, it is characterized in that the medical material of this Miao Ethnomedicine by following quality proportioning: the Radix Polygoni Multiflori 20 ~ 25, Radix Polygalae 20 ~ 25, Bulbus Lilii 30 ~ 35, Caulis Polygoni Multiflori 15 ~ 20, Concha Haliotidis 15 ~ 20, Cortex Cinnamomi 10 ~ 15, Radix Scrophulariae 10 ~ 15, Radix Rehmanniae 20 ~ 25, Radix Curcumae 15 ~ 20, Rhizoma Coptidis 10 ~ 15, Flos Carthami 10 ~ 15, Radix Angelicae Sinensis 20 ~ 25, Spica Prunellae 20 ~ 25; The described Radix Polygoni Multiflori must be concocted in advance;
Make as follows: first the Radix Polygoni Multiflori is conventionally concocted into Radix Polygoni Multiflori Preparata, for subsequent use; Again all the other 12 taste medical materials are cleaned respectively, with hot-air seasoning, be processed into fragment together with Radix Polygoni Multiflori Preparata; With disinfection by ultraviolet light, after formula proportion mixing, put into the pond that pottery or copper tank or wooden barrel or cement be built into and add water retting, and pass into steam 3 heating, till wherein active ingredient proposes substantially; Extractum is made in filtration; Fire drying in using again, pulverizes, grinds to form 60 order powder, mix homogeneously; Last pharmaceutical technology routinely, is pressed into tablet or incapsulates, and every 1g or every sheet 1g, obtains tablet or capsule.
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| 中医治疗失眠的研究近况;石春明等;《陕西中医学院学报》;20080331;第31卷(第2期);60-62 * |
| 更年期综合征中医用药特点、症状及证型分布的现代文献分析;刘雁峰等;《北京中医药大学学报》;20080228;第31卷(第2期);125-130 * |
| 近十年来中医治疗妇女更年期综合征概述;李晓丽等;《山东中医学院学报》;19931231;第17卷(第6期);59-62 * |
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