CN103263609B - Traditional Chinese medicine for treating ureteral calculus and preparation method thereof - Google Patents
Traditional Chinese medicine for treating ureteral calculus and preparation method thereof Download PDFInfo
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- CN103263609B CN103263609B CN201310237257.4A CN201310237257A CN103263609B CN 103263609 B CN103263609 B CN 103263609B CN 201310237257 A CN201310237257 A CN 201310237257A CN 103263609 B CN103263609 B CN 103263609B
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Abstract
The invention discloses a traditional Chinese medicine for treating ureteral calculus and belongs to medical preparations. The traditional Chinese medicine is prepared from nine main medicines and seven adjuvant medicines, wherein the main medicines comprise the following medical materials in parts by weight: 15-20 parts of lysimachia christinae hance, 15-20 parts of gizzard pepsin, 15-20 parts of semen plantaginis, 15-20 parts of radix achyranthis bidentatae, 15-20 parts of Chinese wax gourd peel, 15-20 parts of scouring rush, 8-10 parts of fructus aurantii, 10-15 parts of pyrrosia lingua and 8-10 parts of frankincense; and the adjuvant medicines comprise the following medical materials in parts by weight: 8-10 parts of safflower carthamus, 8-10 parts of semen coicis, 10-15 parts of poria cocos, 10-15 parts of caulis akebiae, 8-10 parts of preapred monkshood, 8-10 parts of radix ophiopogonis and 8-10 parts of root of rehmannia. The preparation method comprises the following steps of: washing the medical materials, drying, processing the medical materials to be fragments, disinfecting, putting the medical materials into a vessel, and adding water to repeatedly decoct for three times; after filtering, processing the liquid medicine to be extract, then drying the extract by moderate heat, crushing and grinding; and at last, pressing into tablets or encapsulating to obtain the traditional Chinese medicine for treating ureteral calculus. The traditional Chinese medicine is obvious in treatment effect and is suitable for treating male and female patients of ureteral calculus.
Description
Technical field
The present invention is relevant with medicinal preparation, in particular to the medicine for the treatment of ureteral calculus, also relates to the preparation method of this Chinese medicine.
Background technology
Ureteral calculus be generally renal calculus in discharge process, being temporarily obstructed causes in ureteral stenosis.As ureteral calculus is not discharged, may grow up gradually at stop position.Ureteral calculus conventionally, with obvious renal colic, hematuria symptom, also often causes and blocks and hydronephrosis.
With the Chinese patent application part of Chinese crude drug treatment ureteral calculus, only there is at present No. 200810133143.4 < < Chinese medicine composition > > who treats kidney and ureteral calculus, 200910180929.6 the Chinese medicine preparation > > of number < < treatment ureteral calculus, the Chinese medicine preparation > > of the Chinese medicine preparation > > of No. 200910211288.6 < < treatment ureteral calculus and No. 200910180929.6 < < treatment ureteral calculus.These patent applications all disclose some and have utilized the Drug therapy ureteral calculus of Chinese crude drug preparation, but its curative effect there is no report.Therefore people are still at exploitation renewal, more effective medicine.
Summary of the invention
Object of the present invention is just to provide a kind of Chinese medicine for the treatment of ureteral calculus, to increase the types of drugs for the treatment of ureteral calculus, enables the health service into people.
Another object of the present invention is to provide the preparation method of this Chinese medicine.
The Chinese medicine for the treatment of ureteral calculus of the present invention is formulated by 9 taste principal agents and 7 taste accessory drugss, and the quality of medicinal material proportioning of principal agent and accessory drugs is:
Principal agent: Herba Lysimachiae 15～20, Endothelium Corneum Gigeriae Galli 15～20, Semen Plantaginis 15～20, Radix Achyranthis Bidentatae 15～20, Exocarpium Benincasae 15～20, Herba Equiseti Hiemalis 15～20, Fructus Aurantii 8～10, Folium Pyrrosiae 10～15, Olibanum 8～10;
Accessory drugs: Flos Carthami 8～10, Semen Coicis 8～10, Poria 10～15, Caulis Akebiae 10～15, Radix Aconiti Lateralis Preparata 8～10, Radix Ophiopogonis 8～10, the Radix Rehmanniae 8～10.
The optimization formula of this Chinese medicine is:
Principal agent: Herba Lysimachiae 18, Endothelium Corneum Gigeriae Galli 18, Semen Plantaginis 18, Radix Achyranthis Bidentatae 18, Exocarpium Benincasae 18, Herba Equiseti Hiemalis 16, Fructus Aurantii 9, Folium Pyrrosiae 13, Olibanum 9
Accessory drugs: Flos Carthami 8, Semen Coicis 10, Poria 14, Caulis Akebiae 14, Radix Aconiti Lateralis Preparata 9, Radix Ophiopogonis 9, the Radix Rehmanniae 9.
In above-mentioned principal agent medical material:
Herba Lysimachiae is the whole herb with root of labiate HUOXUEDAN (Glechoma longituba), bitter but sweet flavor, cool in nature, has heat clearing away, diuresis, antitussive, detumescence, detoxicating functions (seeing Jiangsu new medical college volume < < Chinese medicine voluminous dictionary > > 1399-1400 page); Endothelium Corneum Gigeriae Galli is the dry gizzard tunica intima of Phasianidae animal man chicken (Gallus gallus domesticus), sweet in the mouth, property flat, can removing food stagnancy stagnant, strengthening the spleen and stomach (seeing 1203 pages of < < Chinese medicine voluminous dictionary > >); The herb of thing Herba Polygoni Avicularis (Polygonum aviculare) is planted by Herba Polygoni Avicularis Wei Liao section, bitter in the mouth, cold in nature, has diuresis, heat clearing away effect (seeing 2329 pages of < < Chinese medicine voluminous dictionary > >); Semen Plantaginis is (Plantago asiatica), and sweet in the mouth is cold in nature, can clearing away heat to improve acuity of vision, can control conjunctival congestion hide from view (seeing < < Chinese medicine voluminous dictionary > > P403); Radix Achyranthis Bidentatae, root for amaranthaceous plant Radix Achyranthis Bidentatae (Achyranthes bidentata), sweet in the mouth picric acid, property is put down, and has the effect (seeing 417 pages of Zhejiang new medical college volume < < Chinese medicine voluminous dictionary > >) of dissipating blood stasis blood, subduing inflammation; Exocarpium Benincasae is the outer peel of cucurbitaceous plant Fructus Benincasae (Benincasa hispida), sweet in the mouth, cool in nature, there is inducing diuresis to remove edema effect (seeing 2329 pages of < < Chinese crude drug voluminous dictionary > >); Herba Equiseti Hiemalis, herb for Equisetaceae plant Herba Equiseti Hiemalis (Equisetum hiemale), sweet-bitter flavor, property is put down, and has wind-dispelling heat-dissipating, expelling pathogenic factors from muscles nebula removing effect (seeing 356 pages of < < Chinese crude drug voluminous dictionary > >); Fructus Aurantii, for rutaceae Fructus Ponciri Trifoliatae (Fructus Ponciri Trifoliatae Immaturus) (Poncirus trifoliata) mellow fruit nearly, cool in nature, bitter in the mouth is pungent, energy dispelling the stagnated QI, removing food stagnancy (seeing 1507 pages of < < Chinese medicine voluminous dictionary > >); Olibanum, gum resin for olive subject plant Boswellia carterii Birdw (Boswellia carterii), bitter in the mouth is pungent, warm in nature, there is regulating qi and activating blood, analgesic therapy, chases after malicious effect (seeing 1379 pages of < < Chinese crude drug voluminous dictionary > >).
In above-mentioned accessory drugs medical material:
Flos Carthami is top and the stigma of irides Stigma Croci (Crocus sativus) style, sweet in the mouth, property is put down, energy blood circulation promoting and blood stasis dispelling, dispersing stagnation and relieving accumulation of pathogens (seeing 2671 pages of < < Chinese medicine voluminous dictionary > >); The kernel of Semen Coicis Wei He Ordering-the section plant Semen Coicis (Coix lachrymal-jobi), slightly sweet flavor, cool in nature, there are spleen invigorating, tonifying the lung, heat clearing away, dampness removing effect (seeing 2645 pages of < < Chinese crude drug voluminous dictionary > >); Poria is the dry sclerotia of Polyporaceae plant Poria (Poria cocos), slightly sweet flavor, property is put down, and has the effect (seeing 1596 pages of < < Chinese medicine voluminous dictionary > >) of eliminating dampness and diuresis, happy Fructus Alpiniae Oxyphyllae; Folium Pyrrosiae is the leaf of Plants of Polypodiaceae Folium Pyrrosiae (Pyrrosia lingua), bitter but sweet flavor, cool in nature, there is relieving stranguria by diuresis, the lung heat clearing effect (seeing 579 pages of < < Chinese crude drug voluminous dictionary > >) that expels the heat-evil; Caulis Akebiae is the woody stems of plants of Lardizabalaceae Caulis Akebiae (Akebia trifoliata), bitter in the mouth, cool in nature, there is pathogenic fire purging row water, promoting blood circulation effect (seeing 357 pages of < < Chinese crude drug voluminous dictionary > >); Radix Aconiti Lateralis Preparata, concoct the Radix Aconiti Lateralis Preparata that after-ripening is used, daughter root (other raw tuber) for ranunculaceae plant Aconitum carmichjaelii Debx. (Aconitum carmichaeli), acrid-sweet flavor, hot in nature, poisonous, can mend fire, cold expelling wet down (seeing 1191 pages of < < Chinese crude drug voluminous dictionary > >) by recuperating depleted YANG; Radix Ophiopogonis, it is Radix Ophiopogonis, tuber for liliaceous plant dwarf lilyturf (Ophiopogon japonicus), sweet and slightly bitter taste, property flat, can nourishing YIN and moistening the lung, the liver benefiting that clears away heart-fire (seeing 1024 pages of < < Chinese medicine voluminous dictionary > >); The Radix Rehmanniae, it is Radix Rehmanniae, fresh rhizome for scrophulariaceae rehmannia glutinosa plant (Rehmannia glutinosa), sweet-bitter flavor, cold in nature, has heat clearing away, removing heat from blood, an effect of promoting the production of body fluid (seeing 2568 pages of < < Chinese medicine voluminous dictionary > >).
Above-mentioned medical material should meet the regulation under each medical material item in one of < < Chinese Pharmacopoeia > > nineteen ninety-five version.
The preparation method of the Chinese medicine of the treatment ureteral calculus that inventor provides is that above-mentioned 16 taste medical materials are cleaned respectively, with hot-air seasoning, be processed into fragment, use again disinfection by ultraviolet light, putting into pottery or copper tank or copper utensil (should not with iron pan) adds water and repeatedly decocts 3 times, 1～2 hour for the first time, 0.5～1 hour for the second time, 0.5 hour for the third time; After filtering, medicinal liquid is made extractum; Fire drying in using again, pulverizes, grinds to form 60 order powder; Finally pharmaceutical technology routinely, is pressed into tablet or incapsulates, and every 1g or every 1g, obtain tablet or capsule.
The above-mentioned pharmaceutical technology that is pressed into tablet comprises: 1. the 60 order powder that make are added to adjuvant, main adjuvant is adhesive modified starch, mix homogeneously; 2. in mixed powder, add water as wetting agent, make soft material; 3. soft material extruding is sieved, granulation; 4. granule is through super-dry, make its moisture be applicable to and evenly, grain graininess is suitable; 5. dried particles, through check, confirms to meet the requirement of tablet; 6. with Chong Yashi or rotary tablet machine, extrude tablet, what be up to the standards is finished product.
The pharmaceutical technology of above-mentioned capsule comprises: 1. prepare or buy and take the capsulae vacuus that gelatin is primary raw material; 2. the 60 order powder that make are crossed to sieve No. 6, the fine powder obtaining is standby; 3. with the artificial medicated powder of loading, enter soft capsule, or pack medicated powder into automatic filling machine; 4. the effective ingredient of medicated powder and quality are tested, the qualified rear glue with gelatin, in the sealing of capsule capping place, obtains finished product.
Inventor points out: this Chinese medicine also can be prepared into any conventional peroral dosage form by conventional method of Chinese medicinal.No matter which kind of dosage form, all must deposit according to the relevant regulations of drug stock control.
The Chinese medicine using method for the treatment of ureteral calculus of the present invention is oral, and boiled water takes, every day 2 times, each 3～4 slices/.
The Chinese medicine for the treatment of ureteral calculus of the present invention is tested application clinical, treatment ureteral calculus patient 27 examples, and 23 people achieve good results, and 3 people are effective, and 1 people is invalid.Model case has:
Case one: Nie, female, 43 years old.Between in April, 2005, patient feels that suddenly right lumbar region pain feels bad, cold extremities, and vomiting, is ureteral calculus through examination in hospital, there is 0.4 * 0.6 centimetre of calculus shade ureter lower end, left side.On August 20th, 2005 start to take our bright medicine, August 30, discharged a calculus as large in Semen Phaseoli, continue to take medicine continuously, successively get rid of calculus not of uniform size 3 times, rear pain disappears, and through hospital's film making, checks that intra-ureteral calculus shade disappears.
Case two: to certain, in March, 2007, find flank pain, but without dysurea, urgent micturition phenomenon, pain is aggravated gradually, take tablet for alleviating pain invalid, through examination in hospital, find that ureter has one piece of 0.3 * 0.5 ㎝ calculus shape, through taking medicine of the present invention after 8 days, X-ray examination is shown in that calculus drops to bladder, take continuously this medicine after 15 days, 1 piece of the thunder egg that in urethra, discharge Semen Glycines is large, rest a period of time health recovers substantially.
Case three: Nie, man, in January, 2009, the unexpected left lower quadrant angor of patient is unbearably, frequent micturition frequent micturition, after by emergency tender, send city's examination in hospital, left side is equivalent to the aobvious high shade of 0.5 * 0.7 ㎝ density of fourth lumbar vertebra, transverse process external series gap place, is diagnosed as: left side ureteral calculus, after take this medicine 5 days, calculus is discharged, and pain disappears, and follows up a case by regular visits to not recurrence.
The Chinese medicine for the treatment of ureteral calculus of the present invention is easy to process, and curative effect is obvious, is applicable to treat the patient of men and women's ureteral calculus.
The specific embodiment
Embodiment treats the Chinese medicine of ureteral calculus according to the following step preparation:
Get principal agent: Herba Lysimachiae 18g, Endothelium Corneum Gigeriae Galli 18g, Semen Plantaginis 18g, Radix Achyranthis Bidentatae 18g, Exocarpium Benincasae 18g, Herba Equiseti Hiemalis 16g, Fructus Aurantii 9g, Folium Pyrrosiae 13g, Olibanum 9g, get again accessory drugs: Flos Carthami 8g, Semen Coicis 10g, Poria 14g, Caulis Akebiae 14g, Radix Aconiti Lateralis Preparata 9g, Radix Ophiopogonis 9g, Radix Rehmanniae 9g.
Above-mentioned medical material is cleaned respectively in advance, with hot-air seasoning, be processed into fragment, then use disinfection by ultraviolet light, put into terrine add water and repeatedly decoct 3 times according to formula, 2 hours for the first time, 1 hour for the second time, 0.5 hour for the third time, after filtering, medicinal liquid was made extractum; Fire drying in using again, pulverizes, grinds to form 60 order powder; Finally pharmaceutical technology routinely, is pressed into tablet or incapsulates, and every 1g or every 1g, obtain tablet.Must treat 210 of the pills of ureteral calculus.
Claims (3)
1. treat a Chinese medicine for ureteral calculus, it is characterized in that this Chinese medicine is formulated by 9 taste principal agents and 7 taste accessory drugss, the quality of medicinal material proportioning of principal agent and accessory drugs is:
Principal agent: Herba Lysimachiae 15～20, Endothelium Corneum Gigeriae Galli 15～20, Semen Plantaginis 15～20, Radix Achyranthis Bidentatae 15～20, Exocarpium Benincasae 15～20, Herba Equiseti Hiemalis 15～20, Fructus Aurantii 8～10, Folium Pyrrosiae 10～15, Olibanum 8～10;
Accessory drugs: Flos Carthami 8～10, Semen Coicis 8～10, Poria 10～15, Caulis Akebiae 10～15, Radix Aconiti Lateralis Preparata 8～10, Radix Ophiopogonis 8～10, the Radix Rehmanniae 8～10.
2. Chinese medicine as claimed in claim 1, is characterized in that this Chinese medicine is formulated by 9 taste principal agents and 7 taste accessory drugss, and the quality of medicinal material proportioning of principal agent and accessory drugs is:
Principal agent: Herba Lysimachiae 18, Endothelium Corneum Gigeriae Galli 18, Semen Plantaginis 18, Radix Achyranthis Bidentatae 18, Exocarpium Benincasae 18, Herba Equiseti Hiemalis 16, Fructus Aurantii 9, Folium Pyrrosiae 13, Olibanum 9;
Accessory drugs: Flos Carthami 8, Semen Coicis 10, Poria 14, Caulis Akebiae 14, Radix Aconiti Lateralis Preparata 9, Radix Ophiopogonis 9, the Radix Rehmanniae 9.
3. described in preparation claim 1 or 2, treat the method for the Chinese medicine of ureteral calculus, it is characterized in that above-mentioned 16 taste Chinese medicines to clean respectively, with hot-air seasoning, be processed into fragment, use again disinfection by ultraviolet light, put into pottery or copper utensil and add water and repeatedly decoct 3 times, 1～2 hour for the first time, 0.5～1 hour for the second time, 0.5 hour for the third time; After filtering, medicinal liquid is made extractum; Fire drying in using again, pulverizes, grinds to form 60 order powder; Finally pharmaceutical technology routinely, is pressed into tablet or incapsulates, and every 1g or every 1g, obtain tablet or capsule.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1720945A (en) * | 2005-06-28 | 2006-01-18 | 郑阿权 | Medicine for treating calculus in urinary system |
| CN101810790A (en) * | 2009-11-09 | 2010-08-25 | 景玲 | Chinese medicinal preparation for curing ureteral calculi |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1720945A (en) * | 2005-06-28 | 2006-01-18 | 郑阿权 | Medicine for treating calculus in urinary system |
| CN101810790A (en) * | 2009-11-09 | 2010-08-25 | 景玲 | Chinese medicinal preparation for curing ureteral calculi |
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