CN103830535B - Pharmaceutical composition for the treatment of rhinitis and its production and use - Google Patents
Pharmaceutical composition for the treatment of rhinitis and its production and use Download PDFInfo
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- CN103830535B CN103830535B CN201410069112.2A CN201410069112A CN103830535B CN 103830535 B CN103830535 B CN 103830535B CN 201410069112 A CN201410069112 A CN 201410069112A CN 103830535 B CN103830535 B CN 103830535B
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Abstract
nullThe invention provides a kind of pharmaceutical composition treating rhinitis，It is to include the preparation that the crude drug of following weight proportion is prepared from: Herba Pogostemonis 12 18 parts、Radix Scrophulariae 15 25 parts、Flos Magnoliae 6 12 parts、7 13 parts of Radix Rubiae、Bulbus Fritillariae Thunbergii 9 15 parts、Radix Bupleuri 6 12 parts、Radix Angelicae Sinensis 7 13 parts、Ramulus Uncariae Cum Uncis 12 18 parts、Herba Menthae 12 18 parts、Retinervus Luffae Fructus 12 18 parts、Caulis Lonicerae 12 18 parts、5 11 parts of Radix Glycyrrhizae、The Radix Angelicae Dahuricae 7 13 parts、Pheretima 7 13 parts、Pericarpium Granati 7 13 parts、Fructus Chebulae 7 13 parts、Periostracum Cicadae 48 parts、The Radix Astragali 7 13 parts、Herba Schizonepetae charcoal 7 13 parts、Fructus Mume 7 13 parts、Radix Cynanchi Paniculati 7 13 parts、Ramulus Cinnamomi 25 parts、The Radix Paeoniae Alba 9 15 parts、Nidus Vespae 48 parts、Radix Arnebiae (Radix Lithospermi) 7 13 parts、Flos Chrysanthemi Indici 7 13 parts、Concha Ostreae 15 25 parts、Fructus Schisandrae Chinensis 9 15 parts、12 18 parts of Herba Spirodelae、Herba Ecliptae 7 13 parts、Fructus Momordicae 15 25 parts、Radix Platycodonis 7 13 parts.Pharmaceutical composition of the present invention can effectively treat chronic allergic rhinitis, the symptom such as the nasal obstruction caused by rhinitis, rhinocnesmus, many tears, thin nasal discharge, olfactory sensation decline, headache or giddy there are the effects such as elimination or alleviation, and treatment total effective rate is high, provides new selection for clinical application.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition treating rhinitis and its production and use.
Background technology
Rhinitis i.e. nasal cavity inflammatory diseases, be virus, antibacterial, allergen, various physical and chemical factor and some
The inflammation of the bronchia mucosal that systemic disease causes.Chronic allergic rhinitis i.e. allergic rhinitis, refer to spy
Medium (mainly histamine) release mainly mediated by IgE after answering property individuality contact allergen, and have many
Plant the nasal mucosa non-infectious inflammatory disease that immunologically competent cell and cytokine etc. participate in.What it occurred must
Condition is wanted to have 3: 1. specific antigen i.e. causes the material of organism immune response.2. atopic individuals is i.e.
So-called individual variation, allergic constitution.3. specific antigen and spy answer both type individualities to meet.Allergia nose
Inflammation is a global health problem, may result in numerous disease and disability.The allusion quotation of allergic rhinitis
Type symptom is mainly paroxysmal sneeze, clear water sample nasal mucus, nasal obstruction and rhinocnesmus, and part is with hyposmia.
At present for the treatment of allergic rhinitis, the following means of main employing: (1) avoids contact with anaphylactogen；
(2) Drug therapy；(3) immunization therapy；(4) surgical intervention.Wherein, Drug therapy is the most often
Critical treatment means, its common drug mostly is Western medicine, such as antihistaminic, glucocorticoid, anti-white
Triolefin medicine etc..But these medicines have certain toxic and side effects to human body, and still cannot thoroughly treat.The traditional Chinese medical science
Also having longer history in treatment allergic rhinitis, the traditional Chinese medical science is so-called " allergic rhinitis ", is chronic anaphylaxis nose
Inflammation, common with the one that unexpected and the rhinocnesmus of recurrent exerbation, sneeze, stream thin nasal discharge, nasal obstruction etc. are characterized,
Multiple cacorhinia.Therefore, from Chinese medicine, the compound medicines of chronic allergic rhinitis can be effectively treated in research and development
Thing, has been referred to as the focus of research.
Summary of the invention
It is an object of the invention to provide a kind of pharmaceutical composition treating rhinitis and preparation method thereof and use
On the way.
The invention provides the pharmaceutical composition for the treatment of rhinitis, it is the crude drug including following weight proportion
The preparation being prepared from:
Herba Pogostemonis 12-18 part, Radix Scrophulariae 15-25 part, Flos Magnoliae 6-12 part, Radix Rubiae 7-13 part, Bulbus Fritillariae Thunbergii
9-15 part, Radix Bupleuri 6-12 part, Radix Angelicae Sinensis 7-13 part, Ramulus Uncariae Cum Uncis 12-18 part, Herba Menthae 12-18 part, Fructus Luffae
Network 12-18 part, Caulis Lonicerae 12-18 part, Radix Glycyrrhizae 5-11 part, Radix Angelicae Dahuricae 7-13 part, Pheretima 7-13 part,
Pericarpium Granati 7-13 part, Fructus Chebulae's 7-13 part, Periostracum Cicadae 4-8 part, Radix Astragali 7-13 part, Herba Schizonepetae charcoal 7-13 part,
Fructus Mume 7-13 part, Radix Cynanchi Paniculati 7-13 part, Ramulus Cinnamomi 2-5 part, Radix Paeoniae Alba 9-15 part, Nidus Vespae 4-8 part,
Radix Arnebiae (Radix Lithospermi) 7-13 part, Flos Chrysanthemi Indici 7-13 part, Concha Ostreae 15-25 part, Fructus Schisandrae Chinensis 9-15 part, Herba Spirodelae 12-18
Part, Herba Ecliptae 7-13 part, Fructus Momordicae 15-25 part, Radix Platycodonis 7-13 part.
Further, it is to include the preparation that the crude drug of following weight proportion is prepared from:
Herba Pogostemonis 15 parts, Radix Scrophulariae 20 parts, Flos Magnoliae 9 parts, 10 parts of Radix Rubiae, Bulbus Fritillariae Thunbergii 12 parts, Radix Bupleuri
9 parts, Radix Angelicae Sinensis 10 parts, Ramulus Uncariae Cum Uncis 15 parts, Herba Menthae 15 parts, Retinervus Luffae Fructus 15 parts, Caulis Lonicerae 15 parts, sweet
Grass 8 parts, the Radix Angelicae Dahuricae 10 parts, Pheretima 10 parts, Pericarpium Granati 10 parts, Fructus Chebulae 10 parts, Periostracum Cicadae 6 parts, Huang
Stilbene 10 parts, Herba Schizonepetae charcoal 10 parts, Fructus Mume 10 parts, Radix Cynanchi Paniculati 10 parts, Ramulus Cinnamomi 3 parts, the Radix Paeoniae Alba 12 parts,
Nidus Vespae 6 parts, Radix Arnebiae (Radix Lithospermi) 10 parts, Flos Chrysanthemi Indici 10 parts, Concha Ostreae 20 parts, Fructus Schisandrae Chinensis 12 parts, Herba Spirodelae 15
Part, Herba Ecliptae 10 parts, Fructus Momordicae 20 parts, Radix Platycodonis 10 parts.
Further, it is the preparation being prepared from by the crude drug of following weight proportion:
Herba Pogostemonis 12-18 part, Radix Scrophulariae 15-25 part, Flos Magnoliae 6-12 part, Radix Rubiae 7-13 part, Bulbus Fritillariae Thunbergii
9-15 part, Radix Bupleuri 6-12 part, Radix Angelicae Sinensis 7-13 part, Ramulus Uncariae Cum Uncis 12-18 part, Herba Menthae 12-18 part, Fructus Luffae
Network 12-18 part, Caulis Lonicerae 12-18 part, Radix Glycyrrhizae 5-11 part, Radix Angelicae Dahuricae 7-13 part, Pheretima 7-13 part,
Pericarpium Granati 7-13 part, Fructus Chebulae's 7-13 part, Periostracum Cicadae 4-8 part, Radix Astragali 7-13 part, Herba Schizonepetae charcoal 7-13 part,
Fructus Mume 7-13 part, Radix Cynanchi Paniculati 7-13 part, Ramulus Cinnamomi 2-5 part, Radix Paeoniae Alba 9-15 part, Nidus Vespae 4-8 part,
Radix Arnebiae (Radix Lithospermi) 7-13 part, Flos Chrysanthemi Indici 7-13 part, Concha Ostreae 15-25 part, Fructus Schisandrae Chinensis 9-15 part, Herba Spirodelae 12-18
Part, Herba Ecliptae 7-13 part, Fructus Momordicae 15-25 part, Radix Platycodonis 7-13 part.
Preferably, it is the preparation being prepared from by the crude drug of following weight proportion:
Herba Pogostemonis 15 parts, Radix Scrophulariae 20 parts, Flos Magnoliae 9 parts, 10 parts of Radix Rubiae, Bulbus Fritillariae Thunbergii 12 parts, Radix Bupleuri
9 parts, Radix Angelicae Sinensis 10 parts, Ramulus Uncariae Cum Uncis 15 parts, Herba Menthae 15 parts, Retinervus Luffae Fructus 15 parts, Caulis Lonicerae 15 parts, sweet
Grass 8 parts, the Radix Angelicae Dahuricae 10 parts, Pheretima 10 parts, Pericarpium Granati 10 parts, Fructus Chebulae 10 parts, Periostracum Cicadae 6 parts, Huang
Stilbene 10 parts, Herba Schizonepetae charcoal 10 parts, Fructus Mume 10 parts, Radix Cynanchi Paniculati 10 parts, Ramulus Cinnamomi 3 parts, the Radix Paeoniae Alba 12 parts,
Nidus Vespae 6 parts, Radix Arnebiae (Radix Lithospermi) 10 parts, Flos Chrysanthemi Indici 10 parts, Concha Ostreae 20 parts, Fructus Schisandrae Chinensis 12 parts, Herba Spirodelae 15
Part, Herba Ecliptae 10 parts, Fructus Momordicae 20 parts, Radix Platycodonis 10 parts.
Wherein, it is the medicated powder of the crude drug by described proportioning or the water of crude drug or/and ethanol extraction
For active component, add the preparation that pharmaceutically conventional adjuvant or complementary composition are prepared from.
Wherein, described preparation is through gastrointestinal absorption preparation or nasal cavity administrated preparation.
Described through gastrointestinal absorption preparation be oral liquid, capsule, powder, tablet, pill, unguentum or
Granule.
Present invention also offers the preparation method of aforementioned pharmaceutical compositions, it includes following operating procedure:
(1) by proportioning weighting raw materials；
(2) take the medicated powder of crude drug or the water of crude drug or/and ethanol extraction, add the most normal
Adjuvant or complementary composition be prepared as preparation.
Present invention also offers aforementioned pharmaceutical compositions purposes in the medicine of preparation treatment rhinitis.
Further, described rhinitis is chronic allergic rhinitis.
Further, described medicine be eliminate or alleviate the caused nasal obstruction of rhinitis, rhinocnesmus, many tears, thin nasal discharge,
Olfactory sensation declines, headache is or/and the medicine of dizzy symptom.
Pharmaceutical composition of the present invention is by Ramulus Cinnamomi, Herba Spirodelae, Periostracum Cicadae, Flos Magnoliae, Herba Menthae dispelling wind；The Radix Angelicae Dahuricae, the leaves of pulse plants
Fragrant, Radix Cynanchi Paniculati removing dampness；Radix Scrophulariae, Radix Rubiae, Caulis Lonicerae, Radix Arnebiae (Radix Lithospermi), Flos Chrysanthemi Indici heat clearing away, common dispeling disease and evil
For monarch drug.Ramulus Uncariae Cum Uncis, Concha Ostreae, Nidus Vespae, Pheretima, Radix Paeoniae Alba town liver hold back liver in case producing endogenous wind；Radix Bupleuri,
Retinervus Luffae Fructus evacuates irritability dredging collateral in case producing interior-heat；Radix Astragali replenishing QI to invigorate the spleen, in case producing endogenous dampness, prevents jointly
Continue raw wind, wet, hot and be ministerial drug.Bulbus Fritillariae Thunbergii, Radix Platycodonis reduce phlegm with except nasal meatus secretions；Fructus Mume, the five tastes
Son, Pericarpium Granati, Fructus Chebulae is sour and astringent convergence produce to reduce nasal secretion；Radix Angelicae Sinensis nourishing blood and promoting blood circulation is to help nose viscous
Film healing；Herba Schizonepetae charcoal dispels the wind hemostasis to alleviate nasal bleeding；Herba Ecliptae YIN nourishing is dried to alleviate nasal mucosa,
Above medicine is jointly helped and is helped treatment rhinitis to be adjuvant drug.Radix Glycyrrhizae, Fructus Momordicae coordinating the actions of various ingredients in a prescription are altogether for making medicine.
Pharmaceutical composition of the present invention can effectively treat chronic allergic rhinitis, to the nasal obstruction caused by rhinitis,
The symptom such as rhinocnesmus, many tears, thin nasal discharge, olfactory sensation decline, headache or giddy has the effects such as elimination or alleviation, and
Treatment total effective rate is high, provides new selection for clinical application.
Detailed description of the invention
The preparation method of embodiment 1 present composition
Prescription:
Herba Pogostemonis 15g, Radix Scrophulariae 20g, Flos Magnoliae 9g, Radix Rubiae 10g, Bulbus Fritillariae Thunbergii 12g, Radix Bupleuri 9g, Radix Angelicae Sinensis
10g, Ramulus Uncariae Cum Uncis 15g, Herba Menthae 15g, Retinervus Luffae Fructus 15g, Caulis Lonicerae 15g, Radix Glycyrrhizae 8g, Radix Angelicae Dahuricae 10g,
Dragon 10g, Pericarpium Granati 10g, Fructus Chebulae 10g, Periostracum Cicadae 6g, Radix Astragali 10g, Herba Schizonepetae charcoal 10g, Fructus Mume 10g,
Radix Cynanchi Paniculati 10g, Ramulus Cinnamomi 3g, Radix Paeoniae Alba 12g, Nidus Vespae 6g, Radix Arnebiae (Radix Lithospermi) 10g, Flos Chrysanthemi Indici 10g, Concha Ostreae
20g, Fructus Schisandrae Chinensis 12g, Herba Spirodelae 15g, Herba Ecliptae 10g, Fructus Momordicae 20g, Radix Platycodonis 10g.
Preparation method:
Take above-mentioned raw materials medicine, boiling 3 times, merge decocting liquid, filter, obtain decoction.
The preparation method of embodiment 2 present composition
Prescription:
Herba Pogostemonis 12g, Radix Scrophulariae 25g, Flos Magnoliae 12g, Radix Rubiae 13g, Bulbus Fritillariae Thunbergii 15g, Radix Bupleuri 12g, when
Return 13g, Ramulus Uncariae Cum Uncis 18g, Herba Menthae 18g, Retinervus Luffae Fructus 18g, Caulis Lonicerae 18g, Radix Glycyrrhizae 11g, Radix Angelicae Dahuricae 13g,
Pheretima 13g, Pericarpium Granati 13g, Fructus Chebulae 13g, Periostracum Cicadae 8g, Radix Astragali 13g, Herba Schizonepetae charcoal 13g, Fructus Mume 13g,
Radix Cynanchi Paniculati 13g, Ramulus Cinnamomi 5g, Radix Paeoniae Alba 15g, Nidus Vespae 8g, Radix Arnebiae (Radix Lithospermi) 13g, Flos Chrysanthemi Indici 13g, Concha Ostreae
25g, Fructus Schisandrae Chinensis 15g, Herba Spirodelae 18g, Herba Ecliptae 13g, Fructus Momordicae 25g, Radix Platycodonis 13g.
Preparation method:
Take above-mentioned raw materials medicine, with 50～55%v/v ethanol extraction 3 times, merge alcohol extract, filter, reclaim
After ethanol, concentrate, add appropriate dextrin, pelletize, obtain granule.
The preparation method of embodiment 3 present composition
Prescription:
Herba Pogostemonis 18g, Radix Scrophulariae 15g, Flos Magnoliae 6g, Radix Rubiae 7g, Bulbus Fritillariae Thunbergii 9g, Radix Bupleuri 6g, Radix Angelicae Sinensis
7g, Ramulus Uncariae Cum Uncis 12g, Herba Menthae 12g, Retinervus Luffae Fructus 12g, Caulis Lonicerae 12g, Radix Glycyrrhizae 5g, Radix Angelicae Dahuricae 7g, Pheretima
7g, Pericarpium Granati 7g, Fructus Chebulae 7g, Periostracum Cicadae 4g, Radix Astragali 7g, Herba Schizonepetae charcoal 7g, Fructus Mume 7g, Radix Cynanchi Paniculati
7g, Ramulus Cinnamomi 2g, Radix Paeoniae Alba 9g, Nidus Vespae 4g, Radix Arnebiae (Radix Lithospermi) 7g, Flos Chrysanthemi Indici 7g, Concha Ostreae 15g, Fructus Schisandrae Chinensis
9g, Herba Spirodelae 12g, Herba Ecliptae 7g, Fructus Momordicae 15g, Radix Platycodonis 7g.
Preparation method:
Take above-mentioned raw materials medicine, with 80～85%v/v ethanol extraction 2 times, merge alcohol extract；Medicinal residues add decocting
Boil 2 times, merge decocting liquid；Take alcohol extract, after reclaiming ethanol, merge with decocting liquid, concentrate, add
Appropriate amount of starch, mixing, it is dried, pelletizes, encapsulated, obtain capsule.
The preparation method of embodiment 3 present composition
Prescription:
Herba Pogostemonis 15g, Radix Scrophulariae 20g, Flos Magnoliae 9g, Radix Rubiae 10g, Bulbus Fritillariae Thunbergii 12g, Radix Bupleuri 9g, Radix Angelicae Sinensis
10g, Ramulus Uncariae Cum Uncis 15g, Herba Menthae 15g, Retinervus Luffae Fructus 15g, Caulis Lonicerae 15g, Radix Glycyrrhizae 8g, Radix Angelicae Dahuricae 10g,
Dragon 10g, Pericarpium Granati 10g, Fructus Chebulae 10g, Periostracum Cicadae 6g, Radix Astragali 10g, Herba Schizonepetae charcoal 10g, Fructus Mume 10g,
Radix Cynanchi Paniculati 10g, Ramulus Cinnamomi 3g, Radix Paeoniae Alba 12g, Nidus Vespae 6g, Radix Arnebiae (Radix Lithospermi) 10g, Flos Chrysanthemi Indici 10g, Concha Ostreae
20g, Fructus Schisandrae Chinensis 12g, Herba Spirodelae 15g, Herba Ecliptae 10g, Fructus Momordicae 20g, Radix Platycodonis 10g.
Preparation method:
Take above-mentioned raw materials medicine, boiling 3 times, merge decocting liquid, filter, be concentrated into thick paste, add
Appropriate amount of auxiliary materials, is prepared as unguentum.
Beneficial effects of the present invention is illustrated below by way of test example.
Test example 1 Clinical practice is added up
Chronic allergic rhinitis accepts standard for medical treatment: accepts patient 563 example for medical treatment, is chronic allergic through hospital diagnosis
Property rhinitis, the symptom of the many appearance of patient include intermittence and alternately nasal obstruction, rhinocnesmus, many tears, thin nasal discharge,
Olfactory sensation declines, headache or dizzy.
Therapeutic Method: the decoction of the use embodiment of the present invention 1 preparation, daily 2 times, each 20ml
Concentrated solution, every ml concentrated solution is equivalent to 1.6g raw medicinal herbs, treatment time 7～15 days.
Therapeutic outcome (following table is classified with same symptoms):
Table 1
Table 2
Table 3
Table 4
From above-mentioned experimental result, pharmaceutical composition of the present invention can effectively treat chronic anaphylaxis nose
Inflammation, to the symptom such as the nasal obstruction caused by rhinitis, rhinocnesmus, many tears, thin nasal discharge, olfactory sensation decline, headache or giddy
There are the effects such as elimination or alleviation, and treatment total effective rate is high.
Claims (8)
1. treat the pharmaceutical composition of rhinitis, it is characterised in that: it is by the crude drug of following weight proportion
The preparation being prepared from:
Herba Pogostemonis 12-18 part, Radix Scrophulariae 15-25 part, Flos Magnoliae 6-12 part, Radix Rubiae 7-13 part, Bulbus Fritillariae Thunbergii
9-15 part, Radix Bupleuri 6-12 part, Radix Angelicae Sinensis 7-13 part, Ramulus Uncariae Cum Uncis 12-18 part, Herba Menthae 12-18 part, Fructus Luffae
Network 12-18 part, Caulis Lonicerae 12-18 part, Radix Glycyrrhizae 5-11 part, Radix Angelicae Dahuricae 7-13 part, Pheretima 7-13 part,
Pericarpium Granati 7-13 part, Fructus Chebulae's 7-13 part, Periostracum Cicadae 4-8 part, Radix Astragali 7-13 part, Herba Schizonepetae charcoal 7-13 part,
Fructus Mume 7-13 part, Radix Cynanchi Paniculati 7-13 part, Ramulus Cinnamomi 2-5 part, Radix Paeoniae Alba 9-15 part, Nidus Vespae 4-8 part,
Radix Arnebiae (Radix Lithospermi) 7-13 part, Flos Chrysanthemi Indici 7-13 part, Concha Ostreae 15-25 part, Fructus Schisandrae Chinensis 9-15 part, Herba Spirodelae 12-18
Part, Herba Ecliptae 7-13 part, Fructus Momordicae 15-25 part, Radix Platycodonis 7-13 part.
Pharmaceutical composition the most according to claim 1, it is characterised in that: it is to be joined by following weight
The preparation that the crude drug of ratio is prepared from:
Herba Pogostemonis 15 parts, Radix Scrophulariae 20 parts, Flos Magnoliae 9 parts, 10 parts of Radix Rubiae, Bulbus Fritillariae Thunbergii 12 parts, Radix Bupleuri
9 parts, Radix Angelicae Sinensis 10 parts, Ramulus Uncariae Cum Uncis 15 parts, Herba Menthae 15 parts, Retinervus Luffae Fructus 15 parts, Caulis Lonicerae 15 parts, sweet
Grass 8 parts, the Radix Angelicae Dahuricae 10 parts, Pheretima 10 parts, Pericarpium Granati 10 parts, Fructus Chebulae 10 parts, Periostracum Cicadae 6 parts, Huang
Stilbene 10 parts, Herba Schizonepetae charcoal 10 parts, Fructus Mume 10 parts, Radix Cynanchi Paniculati 10 parts, Ramulus Cinnamomi 3 parts, the Radix Paeoniae Alba 12 parts,
Nidus Vespae 6 parts, Radix Arnebiae (Radix Lithospermi) 10 parts, Flos Chrysanthemi Indici 10 parts, Concha Ostreae 20 parts, Fructus Schisandrae Chinensis 12 parts, Herba Spirodelae 15
Part, Herba Ecliptae 10 parts, Fructus Momordicae 20 parts, Radix Platycodonis 10 parts.
Pharmaceutical composition the most according to claim 1 and 2, it is characterised in that: described preparation is warp
Gastrointestinal absorption preparation or nasal cavity administrated preparation.
Pharmaceutical composition the most according to claim 3, it is characterised in that: described through gastrointestinal absorption
Preparation is oral liquid, capsule, powder, tablet, pill, unguentum or granule.
5. the preparation method of pharmaceutical composition described in Claims 1 to 4 any one, it is characterised in that:
It includes following operating procedure:
(1) by proportioning weighting raw materials；
(2) take the medicated powder of crude drug or the water of crude drug or/and ethanol extraction, add the most normal
Adjuvant or complementary composition be prepared as preparation.
6. pharmaceutical composition described in Claims 1 to 4 any one is in the medicine of preparation treatment rhinitis
Purposes.
Purposes the most according to claim 6, it is characterised in that: described rhinitis is chronic anaphylaxis nose
Scorching.
8. according to the purposes described in claim 6 or 7, it is characterised in that: described medicine is to eliminate or slow
Solve the caused nasal obstruction of rhinitis, rhinocnesmus, many tears, thin nasal discharge, olfactory sensation decline, headache is or/and the medicine of giddy symptom.
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| CN104474332A (en) * | 2014-11-29 | 2015-04-01 | 全椒贡菊园茶厂 | Traditional Chinese medicine formula for treating rhinitis |
| CN104706944A (en) * | 2015-03-31 | 2015-06-17 | 佘延英 | Medicine for treating chronic rhinitis |
| CN105055983B (en) * | 2015-04-26 | 2016-09-21 | 张�林 | Compositions purposes in the medicine of preparation treatment rhinitis |
| CN105168654A (en) * | 2015-09-21 | 2015-12-23 | 江志鑫 | Medicine composition for treating chronic simple rhinitis |
| CN105748777A (en) * | 2016-05-16 | 2016-07-13 | 郎宝英 | Nasal drop for treating dysosmia |
| CN106728346A (en) * | 2016-12-27 | 2017-05-31 | 广州医科大学附属第医院 | A kind of Chinese medicine preparation for treating respiratory disorder |
| AU2018237807B2 (en) | 2017-03-21 | 2023-03-09 | Well Stone Co. | Production method of nasal drop composition, and nasal drop composition |
| CN107714820B (en) * | 2017-09-26 | 2021-06-18 | 成都中医药大学附属医院 | Pharmaceutical composition for treating allergic rhinitis and preparation method and application thereof |
| CN115645489B (en) * | 2022-11-10 | 2023-07-04 | 成都大学 | Nasal drop for treating chronic naso-nasosinusitis and preparation method thereof |
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| CN1994400A (en) * | 2006-10-27 | 2007-07-11 | 边瑞宏 | Medicament for treating nasosinusitis |
| CN101524497A (en) * | 2008-03-07 | 2009-09-09 | 天科仁祥技术（北京）有限责任公司 | Chinese medicinal preparation for treating pharyngitis |
| CN102688384A (en) * | 2012-03-28 | 2012-09-26 | 卢爱萍 | Traditional Chinese medicine decoction for treating chronic pharyngitis |
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| CN103007096A (en) * | 2012-12-25 | 2013-04-03 | 臧金文 | Preparation raw materials of dropping liquid for treating rhinitis and tympanitis and production process thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1994400A (en) * | 2006-10-27 | 2007-07-11 | 边瑞宏 | Medicament for treating nasosinusitis |
| CN101524497A (en) * | 2008-03-07 | 2009-09-09 | 天科仁祥技术（北京）有限责任公司 | Chinese medicinal preparation for treating pharyngitis |
| CN102688384A (en) * | 2012-03-28 | 2012-09-26 | 卢爱萍 | Traditional Chinese medicine decoction for treating chronic pharyngitis |
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