CN104784395A - Orally taken medicine for treating rhinitis and preparation method thereof - Google Patents
Orally taken medicine for treating rhinitis and preparation method thereof Download PDFInfo
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- CN104784395A CN104784395A CN201510214652.XA CN201510214652A CN104784395A CN 104784395 A CN104784395 A CN 104784395A CN 201510214652 A CN201510214652 A CN 201510214652A CN 104784395 A CN104784395 A CN 104784395A
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Abstract
The invention discloses an orally taken medicine for treating rhinitis. The orally taken medicine is prepared from the following medicinal materials in parts by mass: 8-10 parts of pre-fried cocklebur fruit, 12-15 parts of rhizoma acori graminei, 10-15 parts of ligusticum wallichii, 10-15 parts of schizonepeta, 10-15 parts of divaricate saposhnikovia root, 12-15 parts of tribulusterrestris, 10-15 parts of burdock, 10-12 parts of ligusticum sinense oliver, 15-20 parts of radix paeoniae alba, 10-12 parts of fructus viticis, 3-5 parts of asarum, 20-30 parts of astragalus, 12-15 parts of bighead atractylodes rhizome, 10-12 parts of magnolia flower, 12-15 parts of radix angelicae, 10-12 parts of mint, 20-25 parts of parasitic loranthus, 14-16 parts of radix clematidis and 8-10 parts of beautiful sweetgum fruit. The preparation method comprises the following steps: respectively washing, drying and sterilizing 18 medicinal materials except for the cocklebur fruit, adding the pre-fried cocklebur fruit, mixing according to the formula ratio, adding water and soaking, heating, and extracting the active ingredients to prepare extract; and drying, grinding, tabletting or filling in capsules. The medicine is obvious in curative effect and convenient to take and is suitable for treating patients suffering from rhinitis.
Description
Technical field
The present invention is relevant with medicinal preparation, in particular to the medicine for the treatment of rhinitis, also relates to the preparation method of this medicine.
Background technology
The inflammation of the bronchia mucosal that rhinitis (rhinitis) i.e. nasal cavity inflammatory diseases is virus, antibacterial, allergen, various physical and chemical factor and some systemic disease cause.The main pathological change of rhinitis is bronchia mucosal hyperemia, swelling, ooze out, hypertrophy, atrophy or necrosis etc.Doctor trained in Western medicine commonly uses intranasal administration and oral drugs are treated.
In recent years, the achievement in research for the treatment of rhinitis increases very fast, with nearly 500 of the Chinese patent application part of Chinese medicinal herbs treatment rhinitis, applies for nearly all in recent years.Such as No. ZL201210588037.1 " a kind of Chinese medicine for outer use for the treatment of rhinitis ", No. ZL201310261169.8 " a kind of Chinese medicine composition for the treatment of chronic rhinitis ", No. ZL201310340438.X " a kind of Chinese medicine composition for the treatment of rhinitis ", No. ZL201310015809.7 " Chinese medicine composition of a kind for the treatment of of allergic rhinitis and preparation method thereof ", No. ZL201310727584.8 " a kind of Chinese medicine composition for the treatment of rhinitis and preparation method thereof " etc.These patent applications all disclose some Drug therapy rhinitis utilizing Chinese medicinal herbs to prepare, but its curative effect there is no report.Therefore people are still at exploitation renewal, more effective medicine.
Summary of the invention
The present invention aims to provide a kind of endo-medicine for the treatment of rhinitis, to increase the types of drugs for the treatment of rhinitis, enables the health service into people.
Another object of the present invention is to provide the preparation method of this medicine, makes it be able to practical application.
The endo-medicine for the treatment of rhinitis of the present invention is formulated by the medical material of following quality proportioning:
Fructus Xanthii 8 ~ 10, Rhizoma Acori Graminei 12 ~ 15, Rhizoma Chuanxiong 10 ~ 15, Herba Schizonepetae 10 ~ 15, Radix Saposhnikoviae 10 ~ 15, Fructus Atriplicis Sibiricae 12 ~ 15, Fructus Arctii 10 ~ 15, Rhizoma Ligustici 10 ~ 12, Radix Paeoniae Alba 15 ~ 20, Fructus Viticis 10 ~ 12, Herba Asari 3 ~ 5, the Radix Astragali 20 ~ 30, the Rhizoma Atractylodis Macrocephalae 12 ~ 15, Flos Magnoliae 10 ~ 12, the Radix Angelicae Dahuricae 12 ~ 15, Herba Menthae 10 ~ 12, Herba Taxilli 20 ~ 25, Radix Clematidis 14 ~ 16, Fructus Liquidambaris 8 ~ 10;
Described Fructus Xanthii is the medical material of parch in advance.
In above-mentioned medical material:
fructus Xanthiifor feverfew Herba Xanthii (
xanthium sibiricum) fruit of band involucre, sweet in the mouth, warm in nature, poisonous, the wind that can fall apart, pain relieving, damp eliminating, parasite killing (see the new medical college in Jiangsu volume " Chinese medicine voluminous dictionary " 1071 pages);
rhizoma Acori Gramineifor acorus gramineus araceae plant (
acorus gramineus) rhizome, acrid in the mouth, slightly warm in nature, can have one's ideas straightened out, eliminating phlegm, regulate the flow of vital energy, invigorate blood circulation, loose wind, damp eliminating (see " Chinese medicine voluminous dictionary " 612 pages);
rhizoma Chuanxiongfor umbrella section plant Rhizoma Chuanxiong (
ligusticum chuanxiong) rhizome, acrid in the mouth, warm in nature, can activating QI to alleviate the depression, dispeiling pathogenic wind and removing dampness.Promoting blood circulation and stopping pain (see " Chinese medicine voluminous dictionary " 220 pages);
herba Schizonepetaefor labiate Herba Schizonepetae (
schizonepeta tenuifolia) herb, acrid in the mouth, warm in nature, deliver, dispel the wind, treating blood disorders effect (see " Chinese medicine voluminous dictionary " 1553 pages);
radix Saposhnikoviaefor umbelliferae Saposhnikovia divaricata (
saposhnikovia divaricata) root, acrid-sweet flavor, warm in nature, can deliver, dispel the wind, victory is wet, pain relieving (see " Chinese medicine voluminous dictionary " 985 pages);
fructus Atriplicis Sibiricae, i.e. Fructus Tribuli, for zygophyllaceae plant Fructus Tribuli (
tribulus terrestris) fruit, bitter in the mouth is pungent, warm in nature, has loose wind, improving eyesight, the therapeutic method to keep the adverse QI flowing downwards, promoting the circulation of blood effect (see " Chinese medicine voluminous dictionary " 1274 pages);
fructus Arctiifor feverfew Fructus Arctii (
arctium lappa) fruit, bitter in the mouth is pungent, cool in nature, can dispelling wind and heat pathogens, lung qi dispersing rash, subduing swelling and detoxicating (see " Chinese medicine voluminous dictionary " 429 pages);
rhizoma Ligustici, for samphire Rhizoma Ligustici (
ligusticum sinensis) rhizome, acrid in the mouth, warm in nature, can expelling wind and cold, removing dampness to relieve pain (Baidupedia www.baidu.com);
radix Paeoniae Albafor ranunculaceae plant Radix Paeoniae (
paeonia lactiflora) root, bitter in the mouth acid, cool in nature, have nourish blood, the effect of easing the affected liver, the diseases such as conjunctival congestion (see " Chinese medicine voluminous dictionary " 706 pages) can be controlled;
fructus Viticisfor Verbenaceae wild pepper (
vitex rotundifolia) fruit, bitter in the mouth is pungent, cool in nature, can dispelling wind and heat pathogens, the clear sharp head (see " Chinese medicine voluminous dictionary " 2541 pages);
herba Asarifor Fructus Aristolochiae plant Herba Asari (
asarum sieboldii) whole herb with root, acrid in the mouth, warm in nature, can dispel the wind, cold expelling, Hang Shui, have one's ideas straightened out (see " Chinese medicine voluminous dictionary " 1477 pages);
the Radix Astragalifor leguminous plant Radix Astragali (
astragalus membranaceus) root, sweet in the mouth, slightly warm in nature, can stomach reinforcing consolidating superficial resistance, inducing diuresis to remove edema, invigorating the spleen and replenishing QI (see " Chinese medicine voluminous dictionary " 2036 pages);
the Rhizoma Atractylodis Macrocephalaefor the feverfew Rhizoma Atractylodis Macrocephalae (
atractylodes macrocephala) rhizome, bitter but sweet flavor, warm in nature, can spleen reinforcing, stomach reinforcing, dampness and in (see " Chinese medicine voluminous dictionary " 670 pages);
flos Magnoliaefor Magnoliacea plant Flos Magnoliae (
magnolia liliflora) alabastrum, acrid in the mouth, warm in nature, to dispel the wind, sensible (see " Chinese medicine voluminous dictionary " 1157 pages);
the Radix Angelicae Dahuricaefor umbellate form section plant (
angelica dahurica) dry root, acrid in the mouth, warm in nature, can induce sweat cold expelling, wind-expelling pain-stopping, a surname clearing the nasal passage, dampness leukorrhagia stopping, detumescence and apocenosis (see the Pharmacopoeia of the People's Republic of China 2010 editions 97 pages);
herba Menthae, for labiate Herba Menthae (
mentha haplocalyx) herb or leaf, acrid in the mouth, cool in nature, can dispelling wind, heat radiation, wards off dirty, removing toxic substances (see " Chinese medicine dictionary " 2648 pages);
herba Taxillifor Loranthaceae plant Herba Taxilli (
loranthus parasiticus) branch and leaf, bitter but sweet flavor, property put down, can invigorating the liver and kidney, bone and muscle strengthening, except rheumatism, the meridian dredging (see " Chinese medicine voluminous dictionary " 1917 pages);
radix Clematidisfor ranunculaceae plant Radix Clematidis (
clematis chinensis) root, acrid in the mouth is salty, warm in nature, poisonous, can curing rheumatism, the meridian dredging, expectorant saliva, the loose hypochondriac lump (see " Chinese medicine voluminous dictionary " 1632 pages);
fructus Liquidambarisfor Hamamelidaceae Plants sweetgum (
liquidambar formoana) fruit, bitter in the mouth, property is put down, and can dispel the wind, dredging collateral, diuretic, dehumidifying (see " Chinese medicine voluminous dictionary " 2485 pages).
Above-mentioned medical material should meet the regulation in " Chinese Pharmacopoeia " nineteen ninety-five version one under each medical material item.
The preparation method of the endo-medicine of the treatment rhinitis that inventor provides is cleaned respectively by 18 taste medical materials except Fructus Xanthii, dry, sterilize, add the Fructus Xanthii of parch in advance, soak according to putting into wooden barrel after formula proportion mixing, and by steam heated, effective component extracting, makes extractum; Ovendry power is broken into powder again, and pharmaceutical technology is pressed into tablet or incapsulates routinely, and every 1g or every sheet 1g, obtains tablet or capsule.
The above-mentioned pharmaceutical technology being pressed into tablet comprises: 1. 60 obtained order powder are added adjuvant, main adjuvant is adhesive modified starch, mix homogeneously; 2. add water in mixed powder as wetting agent, make soft material; 3. soft material extruding is sieved, make granule; 4. granule is through super-dry, make its moisture be applicable to and evenly, grain graininess is suitable; 5. dried particles is through inspection, confirms the requirement meeting tablet; 6. extrude tablet with Chong Yashi or rotary tablet machine, what be up to the standards is finished product.
The pharmaceutical technology of above-mentioned capsule comprises: 1. preparing or buying with gelatin is the capsulae vacuus of primary raw material; 2. 60 obtained order powder are crossed No. 6 sieves, the fine powder obtained is for subsequent use; 3. enter soft capsule with artificial medicated powder of loading, or load medicated powder with automatic filling machine; 4. test to the effective ingredient of medicated powder and quality, the glue of qualified rear gelatin, in the sealing of capsule capping place, obtains finished product.
Inventor points out: this medicine also can be prepared into any one by conventional method of Chinese medicinal and commonly use peroral dosage form.No matter which kind of dosage form, all must deposit according to the relevant regulations of drug stock control.
The endo-medicine using method for the treatment of of allergic rhinitis of the present invention is oral, warm water delivery service, every day 2 times, each 5 ~ 8/sheet.
Our through clinical application for many years, successful, effective percentage more than 90%.In application process, inventor once first utilized Fructus Xanthii, Rhizoma Acori Graminei, Rhizoma Chuanxiong, Herba Schizonepetae, Radix Saposhnikoviae, Cortex Acanthopanacis Radicis Fructus Tribuli, Fructus Arctii, Rhizoma Ligustici, white peony root, wild pepper, Herba Asari, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Flos Magnoliae 14 taste Chinese medicine constitute formula, 67 patients with rhinitis are treated, result shows, have 30 people's radical cures, 37 people are invalid; Inventor adds the Radix Angelicae Dahuricae, Herba Menthae, Radix Clematidis, Fructus Liquidambaris, Herba Taxilli 5 taste Chinese medicine again in above-mentioned 14 taste Chinese medicines, to above-mentioned 37 invalid human therapies, creates unexpected effect, and result shows, and 34 people's radical cures, 3 people are invalid.Model case has:
Case one: Lin, man, Bijie City, Guizhou Province seven-star close people from district, and in October, 2007, the patient of 13 years old feels nose discomfort, with headache.Be diagnosed as sinusitis through hospital, once took multi-medicament, poor effect, upon somebody's introduction, after taking medicine one week of the present invention, nose discomfort disappears, and headache is also clearly better, and after serveing on one month, all diseases disappear.
Case two: Xiong, man, Guan Tun people from town, Bijie City, 2012 14 years old, in July then, patient, because suffering from sinusitis, had a headache and discontinues one's studies, seeking medical advice everywhere, all without improvement, after being introduced, takes medicine of the present invention, fully recovers after January, goes back to school and attends class.
Case three: Zhu, female, 49 years old, lake street people from town, Bijie City, suffered from sinusitis for many years, frequent flu, headache, household once bought multiple drug for treating rhinitis thing and took poor effect, after change and take medicine first quarter moon of the present invention after, sinusitis has been got well, flu phenomenon also disappears, and follows up a case by regular visits to, half a year, no recurrence.
Case four, thanks certain, man, 51 years old, and Bijie City eight people from stockaded village suffers from nasopharyngitis for many years, headache, nasal obstruction, frequent rhinorrhea, and agony, seeks medical advice everywhere, all to no effect, upon somebody's introduction, takes medicine of the present invention, within 7 days, retires due to illness, takes one month continuously, all disease recoveries from illness.
The endo-medicine curative effect for the treatment of rhinitis of the present invention is obvious, easy to process, is applicable to treat patients with rhinitis.
Detailed description of the invention
embodiment 1endo-medicine tablet according to the following step preparation treatment rhinitis:
Above-mentioned 18 taste medical materials except Fructus Xanthii are cleaned respectively, dry, sterilize, get the Fructus Xanthii 9g of parch in advance afterwards, and Rhizoma Acori Graminei 13g, Rhizoma Chuanxiong 13g, Herba Schizonepetae 13g, Radix Saposhnikoviae 13g, Fructus Atriplicis Sibiricae 13g, Fructus Arctii 13g, Rhizoma Ligustici 11g, Radix Paeoniae Alba 17g, Fructus Viticis 11g, Herba Asari 4g, Radix Astragali 25g, Rhizoma Atractylodis Macrocephalae 14g, Flos Magnoliae 11g, Radix Angelicae Dahuricae 14g, Herba Menthae 11g, Herba Taxilli 22g, Radix Clematidis 15g, Fructus Liquidambaris 9g, after mixing, put into wooden barrel and soak, and by steam heated, effective component extracting, makes extractum; Dry again, be ground into 60 order powder, mix homogeneously; Last pharmaceutical technology routinely, is pressed into tablet, every sheet drug containing 1g, obtained tablet.
Embodiment 2 is according to the endo-medicine capsule of the following step preparation treatment rhinitis
The pretreatment of above-mentioned 19 taste medical materials, with embodiment 1, is dried, is ground into 60 order powder, mix homogeneously; Last pharmaceutical technology routinely, incapsulates, every 1g, obtained capsule.
Claims (2)
1. treat an endo-medicine for rhinitis, it is characterized in that the medical material of this medicine following quality proportioning is formulated:
Fructus Xanthii 8 ~ 10, Rhizoma Acori Graminei 12 ~ 15, Rhizoma Chuanxiong 10 ~ 15, Herba Schizonepetae 10 ~ 15, Radix Saposhnikoviae 10 ~ 15, Fructus Atriplicis Sibiricae 12 ~ 15, Fructus Arctii 10 ~ 15, Rhizoma Ligustici 10 ~ 12, Radix Paeoniae Alba 15 ~ 20, Fructus Viticis 10 ~ 12, Herba Asari 3 ~ 5, the Radix Astragali 20 ~ 30, the Rhizoma Atractylodis Macrocephalae 12 ~ 15, Flos Magnoliae 10 ~ 12, the Radix Angelicae Dahuricae 12 ~ 15, Herba Menthae 10 ~ 12, Herba Taxilli 20 ~ 25, Radix Clematidis 14 ~ 16, Fructus Liquidambaris 8 ~ 10;
Described Fructus Xanthii is the medical material of parch in advance.
2. prepare the method for medicine described in claim 1, it is characterized in that 18 taste medical materials except Fructus Xanthii to clean respectively, dry, sterilize, add the Fructus Xanthii of parch in advance, put into wooden barrel soak according to after formula proportion mixing, and by steam heated, effective component extracting, makes extractum; Ovendry power is broken into powder again, and pharmaceutical technology is pressed into tablet or incapsulates routinely, and every 1g or every sheet 1g, obtains tablet or capsule.
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| CN201510214652.XA CN104784395A (en) | 2015-04-30 | 2015-04-30 | Orally taken medicine for treating rhinitis and preparation method thereof |
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| CN201510214652.XA CN104784395A (en) | 2015-04-30 | 2015-04-30 | Orally taken medicine for treating rhinitis and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105560750A (en) * | 2016-02-22 | 2016-05-11 | 广西梧州制药（集团）股份有限公司 | Traditional Chinese medicine composition for treating rhinitis and preparation method thereof |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1122237A (en) * | 1995-07-08 | 1996-05-15 | 杨伟明 | Nose drops for rhinallergosis |
| CN1672703A (en) * | 2004-03-23 | 2005-09-28 | 胡小兵 | Medicine xinqin tablet for treating allergic rhintis and its prepn |
| CN102512502A (en) * | 2011-12-23 | 2012-06-27 | 荣成市崖头美全口腔诊所 | Traditional Chinese medicinal composition for treating rhinitis |
| CN103948675A (en) * | 2014-05-29 | 2014-07-30 | 张玉芳 | Traditional Chinese medicine for treating chronic rhinitis |
-
2015
- 2015-04-30 CN CN201510214652.XA patent/CN104784395A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1122237A (en) * | 1995-07-08 | 1996-05-15 | 杨伟明 | Nose drops for rhinallergosis |
| CN1672703A (en) * | 2004-03-23 | 2005-09-28 | 胡小兵 | Medicine xinqin tablet for treating allergic rhintis and its prepn |
| CN102512502A (en) * | 2011-12-23 | 2012-06-27 | 荣成市崖头美全口腔诊所 | Traditional Chinese medicinal composition for treating rhinitis |
| CN103948675A (en) * | 2014-05-29 | 2014-07-30 | 张玉芳 | Traditional Chinese medicine for treating chronic rhinitis |
Non-Patent Citations (1)
| Title |
|---|
| 林玉珍等: "温阳益气通窍汤治疗支气管哮喘合并过敏性鼻炎疗效观察", 《新中医》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105560750A (en) * | 2016-02-22 | 2016-05-11 | 广西梧州制药（集团）股份有限公司 | Traditional Chinese medicine composition for treating rhinitis and preparation method thereof |
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Application publication date: 20150722 |