CN104248741A - Traditional Chinese medicinal composition for treating cancers, and preparation method thereof - Google Patents
Traditional Chinese medicinal composition for treating cancers, and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicinal composition for treating cancers, and a preparation method thereof, and belongs to the field of traditional Chinese medicine modernization. Active components of the traditional Chinese medicinal composition for treating cancers are prepared by using the following raw materials, by weight, 678 parts of Radix Astragali, 226 parts of Chinese angelica, 678 parts of Solanum lyratum Thunb, 678 parts of Black Nightshade, 226 parts of Salvia miltiorrhiza, 678 parts of Barbed Skullcap Herb, 339 parts of Indian Mockstrawberry Herb and 226 parts of Radix Curcumae Aromaticae. The reasonable and stable active components are obtained through the preparation method according to research results of the physical and chemical properties and pharmacological effects of components contained in all the raw materials. By adopting the above technical scheme, the quality of the above prepared medicine is stable and controllable, the curative effect of the medicine is substantially stronger than that of dosage forms sold in the present market, and the administration dosage of a patient is reduced. The preparation method has substantial economic and social benefits.
Description
Technical field
The present invention relates to Chinese medicine composition of a kind of Therapeutic cancer and preparation method thereof, belong to modern Chinese traditional medicine field.
Background technology
Cancer (Cancer), also known as malignant tumor (Malignant neoplasm), for by controlling the not normal and disease that causes of growth and proliferation of cell mechanism.Cancerous cell except grow out of control except, arround also locally invading, normal structure even transfers to other parts of health via body-internal-circulation system or lymphsystem.Cancer is the main lethal cause of disease in a whole world, and within 2004, number of cancer deaths reaches 7,400,000 (accounting for 13% of all death tolls).Pulmonary carcinoma, gastric cancer, colon cancer, hepatocarcinoma and breast carcinoma are the arch-criminals of annual most of cancer mortality.But the cancer mortality more than 30% is avoidable.Cancer is caused by a unicellular variation.This variation can be caused by extrinsicfactor and genetic factor.The whole world number of cancer deaths increase continuation, and the year two thousand thirty death toll expectation will reach 1,200 ten thousand.
The common method for the treatment of tumor has surgical operation, radiotherapy, chemotherapy, biotherapy, TCM Therapy etc. both at home and abroad at present, but therapeutic effect is not significantly improved recent decades, and total cure rate is about 10%.Along with development and the utilization of cancer therapy drug, its therapeutic effect is better, but often with larger toxic and side effects for cost, the quality of life of patient obviously declines.
Although also there is the Chinese patent medicine of some treatment tumors, effect is obvious not mostly.Purple imperial gold plaque is applied to deficiency of both QI and blood Patients With Primary Lung Cancer especially, and disease sees spiritlessness and weakness, deficiency of QI with disinclination to talk, feels dizzy, inappetence, spontaneous perspiration of breathing hard, and cough, the patient of pain, its curative effect is obviously better than same veriety.Purple imperial gold plaque also has obvious Attenuation for tumor patients such as hepatocarcinoma, gastric cancer, rectal cancer, colon cancer.
Summary of the invention
First technical problem that the present invention will solve is to provide a kind of Chinese medicine composition of Therapeutic cancer.
Another technical problem that the present invention will solve is to provide the preparation method of above-mentioned Chinese medicine composition.
For achieving the above object, the present invention by the following technical solutions;
A Chinese medicine composition for Therapeutic cancer, its active component is made up of the raw material of following parts by weight: the Radix Astragali 678 parts, Radix Angelicae Sinensis 226 parts, Herba Solani Lyrati 678 parts, Herba Solani Nigri 678 parts, Radix Salviae Miltiorrhizae 226 parts, Herba Scutellariae Barbatae 678 parts, Herba Duchesneae Indicae 339 parts, Radix Curcumae 226 parts.
Described active component adopts following method to prepare:
1, each raw material is taken by proportioning raw materials; Radix Angelicae Sinensis, the Radix Astragali, Radix Curcumae, Herba Scutellariae Barbatae, Herba Duchesneae Indicae, Herba Solani Lyrati, Herba Solani Nigri decoct with water secondary, and first time decocts 2 hours, and second time decocts 1 hour, merge extractive liquid, and filter, filtrate is concentrated into relative density 1.00-1.18 (55 DEG C); Radix Salviae Miltiorrhizae extracts three times, and first time adds alcohol reflux 1.5 hours, filters, and reclaims ethanol; Second time adds ethanol, reflux, extract, 1.5 hours, filters, and reclaims ethanol; Third time adds water, and decoct 2 hours, filtrate and alcohol concentrated solution merge, and are concentrated into relative density 1.01-1.15 (55 DEG C); Above-mentioned water, alcohol concentrated solution are merged, is spray dried to dried cream powder, obtains dry thing A.
2, the Chinese medicine composition of a kind of Therapeutic cancer according to claim 2, it is characterized in that: Radix Angelicae Sinensis, the Radix Astragali, Radix Curcumae, Herba Scutellariae Barbatae, Herba Duchesneae Indicae, Herba Solani Lyrati, Herba Solani Nigri decoct with water secondary, first time adds water by 15 times of medical material weight, decoct 2 hours, second time adds water by 10 times of medical material weight, decocts 1 hour, merge extractive liquid, filter, filtrate is concentrated into relative density 1.00-1.18 (55 DEG C); Radix Salviae Miltiorrhizae extracts three times, and first time press 8 extraordinarily ethanol of medical material weight, and reflux, extract, 1.5 hours, filters, recovery ethanol; Second time press 8 extraordinarily 50% ethanol of medical material weight, and reflux, extract, 1.5 hours filters, recovery ethanol; Third time adds water by 10 times of medical material weight, and decoct 2 hours, filtrate and alcohol concentrated solution merge, and are concentrated into relative density 1.01-1.15 (55 DEG C); Above-mentioned water, alcohol concentrated solution are merged, is spray dried to dried cream powder; Obtain dry thing A.
Described pharmaceutical composition is also containing the acceptable adjuvant of pharmaceutics.
The acceptable adjuvant of described pharmaceutics be selected from starch, microcrystalline Cellulose, sucrose, aspartame, dextrin, lactose, Icing Sugar, glucose, sodium chloride, Carboxymethyl cellulose sodium, crospolyvinylpyrrolidone, magnesium stearate, micropowder silica gel, vitamin C, cysteine, citric acid and sodium sulfite any one or a few.
The dosage form of described Chinese medicine composition is peroral dosage form, includes but not limited to pill, tablet, capsule or oral liquid.The selection of dosage form and the consumption of adjuvant all belong to prior art.
A kind of preparation method of Chinese medicine composition of Therapeutic cancer:
Take the Radix Astragali 678 parts, Radix Angelicae Sinensis 226 parts, Herba Solani Lyrati 678 parts, Herba Solani Nigri 678 parts, Radix Salviae Miltiorrhizae 226 parts, Herba Scutellariae Barbatae 678 parts, Herba Duchesneae Indicae 339 parts, Radix Curcumae 226 parts.Radix Angelicae Sinensis, the Radix Astragali, Radix Curcumae, Herba Scutellariae Barbatae, Herba Duchesneae Indicae, Herba Solani Lyrati, Herba Solani Nigri decoct with water secondary, and first time decocts 2 hours, and second time decocts 1 hour, merge extractive liquid, and filter, filtrate is concentrated into relative density 1.00-1.18 (55 DEG C); Radix Salviae Miltiorrhizae extracts three times, and first time adds alcohol reflux 1.5 hours, filters, and reclaims ethanol; Second time adds ethanol, reflux, extract, 1.5 hours, filters, and reclaims ethanol; Third time adds water, and decoct 2 hours, filtrate and alcohol concentrated solution merge, and are concentrated into relative density 1.01-1.15 (55 DEG C); Above-mentioned water, alcohol concentrated solution are merged, is spray dried to dried cream powder, obtains dry thing A.
Preferred preparation method is:
Each raw material is taken by proportioning raw materials; Radix Angelicae Sinensis, the Radix Astragali, Radix Curcumae, Herba Scutellariae Barbatae, Herba Duchesneae Indicae, Herba Solani Lyrati, Herba Solani Nigri decoct with water secondary, first time adds water by 15 times of medical material weight, decoct 2 hours, second time adds water by 10 times of medical material weight, decoct 1 hour, merge extractive liquid, filter, filtrate is concentrated into relative density 1.00-1.18 (55 DEG C); Radix Salviae Miltiorrhizae extracts three times, and first time press 8 extraordinarily ethanol of medical material weight, and reflux, extract, 1.5 hours, filters, recovery ethanol; Second time press 8 extraordinarily 50% ethanol of medical material weight, and reflux, extract, 1.5 hours filters, recovery ethanol; Third time adds water by 10 times of medical material weight, and decoct 2 hours, filtrate and alcohol concentrated solution merge, and are concentrated into relative density 1.01-1.15 (55 DEG C); Above-mentioned water, alcohol concentrated solution are merged, is spray dried to dried cream powder, obtains dry thing A.
A preparation for the Chinese medicine composition of Therapeutic cancer, said preparation adds the acceptable adjuvant of pharmaceutics with above-mentioned active constituents of medicine, makes the acceptable dosage form of pharmaceutics.During the various dosage form of medicine needed for the active fraction preparation of the Chinese medicine composition utilizing the present invention to obtain, can prepare according to the conventional production process of art of pharmacy.As mixed with one or more carriers by this active component, then make corresponding dosage form.
Advantage of the present invention is: the present invention uses theory of Chinese medical science to analyze prescription composition, and according to physicochemical property and the pharmacological action of each flavour of a drug ingredient, research obtains the preparation method of reasonable, stable active component.Adopt technical scheme of the present invention, on duty go out stable and controllable for quality, curative effect significantly improves compared with existing commercial dosage forms, patient's taking dose reduces pharmaceutical preparation, there is significant economic and social benefit.
Describe technical solution of the present invention in detail by the following examples, do not limit practical range of the present invention with this.
Detailed description of the invention
Embodiment 1: prepare Chinese medicine extract
One, prescription: Radix Astragali 678g, Radix Angelicae Sinensis 226g, Herba Solani Lyrati 678g, Herba Solani Nigri 678g, Radix Salviae Miltiorrhizae 226g, Herba Scutellariae Barbatae 678g, Herba Duchesneae Indicae 339g, Radix Curcumae 226g.
Two, method for making:
Radix Angelicae Sinensis, the Radix Astragali, Radix Curcumae, Herba Scutellariae Barbatae, Herba Duchesneae Indicae, Herba Solani Lyrati, Herba Solani Nigri decoct with water secondary, first time adds water by 15 times of medical material weight, decoct 2 hours, second time adds water by 10 times of medical material weight, decoct 1 hour, merge extractive liquid, filter, filtrate is concentrated into relative density 1.00-1.18 (55 DEG C); Radix Salviae Miltiorrhizae extracts three times, and first time press 8 extraordinarily ethanol of medical material weight, and reflux, extract, 1.5 hours, filters, recovery ethanol; Second time press 8 extraordinarily 50% ethanol of medical material weight, and reflux, extract, 1.5 hours filters, recovery ethanol; Third time adds water by 10 times of medical material weight, and decoct 2 hours, filtrate and alcohol concentrated solution merge, and are concentrated into relative density 1.01-1.15 (55 DEG C); Above-mentioned water, alcohol concentrated solution are merged, is spray dried to dried cream powder, obtains dry thing A and amount to 640g.
Embodiment 2: prepare Chinese medicine extract
One, prescription: Radix Astragali 678g, Radix Angelicae Sinensis 226g, Herba Solani Lyrati 678g, Herba Solani Nigri 678g, Radix Salviae Miltiorrhizae 226g, Herba Scutellariae Barbatae 678g, Herba Duchesneae Indicae 339g, Radix Curcumae 226g.
Two, method for making:
Radix Angelicae Sinensis, the Radix Astragali, Radix Curcumae, Herba Scutellariae Barbatae, Herba Duchesneae Indicae, Herba Solani Lyrati, Herba Solani Nigri decoct with water secondary, first time adds water by 15 times of medical material weight, decoct 2 hours, second time adds water by 10 times of medical material weight, decoct 1 hour, merge extractive liquid, filter, filtrate is concentrated into relative density 1.00-1.18 (55 DEG C); Radix Salviae Miltiorrhizae extracts three times, and first time press 8 extraordinarily ethanol of medical material weight, and reflux, extract, 1.5 hours, filters, recovery ethanol; Second time press 8 extraordinarily 50% ethanol of medical material weight, and reflux, extract, 1.5 hours filters, recovery ethanol; Third time adds water by 10 times of medical material weight, and decoct 2 hours, filtrate and alcohol concentrated solution merge, and are concentrated into relative density 1.01-1.15 (55 DEG C); Above-mentioned water, alcohol concentrated solution are merged, is spray dried to dried cream powder, obtains dry thing A and amount to 640kg.
Embodiment 3: prepare tablet
The active component 100g that embodiment 1 obtains, adds microcrystalline Cellulose 10g, cross-linked pvp 5g, and tabletting, obtains tablet, the heavy 0.65g of every sheet.
Embodiment 4: prepare capsule
The active component 1000g that embodiment 1 obtains, adds starch 250g, and encapsulating capsule, obtains capsule, every heavy 0.50g.
Claims (8)
1. a Chinese medicine composition for Therapeutic cancer, is characterized in that: its active component is made up of the raw material of following parts by weight: the Radix Astragali 678 parts, Radix Angelicae Sinensis 226 parts, Herba Solani Lyrati 678 parts, Herba Solani Nigri 678 parts, Radix Salviae Miltiorrhizae 226 parts, Herba Scutellariae Barbatae 678 parts, Herba Duchesneae Indicae 339 parts, Radix Curcumae 226 parts.
2. the Chinese medicine composition of a kind of Therapeutic cancer according to claim 1, is characterized in that old point of described activity adopts following method to prepare: take each raw material by proportioning raw materials; Radix Angelicae Sinensis, the Radix Astragali, Radix Curcumae, Herba Scutellariae Barbatae, Herba Duchesneae Indicae, Herba Solani Lyrati, Herba Solani Nigri decoct with water secondary, and first time decocts 2 hours, and second time decocts 1 hour, merge extractive liquid, and filter, filtrate is concentrated into relative density 1.00-1.18 (55 DEG C); Radix Salviae Miltiorrhizae extracts three times, and first time adds alcohol reflux 1.5 hours, filters, and reclaims ethanol; Second time adds ethanol, reflux, extract, 1.5 hours, filters, and reclaims ethanol; Third time adds water, and decoct 2 hours, filtrate and alcohol concentrated solution merge, and are concentrated into relative density 1.01-1.15 (55 DEG C); Above-mentioned water, alcohol concentrated solution are merged, is spray dried to dried cream powder, obtains dry thing A.
3. the Chinese medicine composition of a kind of Therapeutic cancer according to claim 2, it is characterized in that: Radix Angelicae Sinensis, the Radix Astragali, Radix Curcumae, Herba Scutellariae Barbatae, Herba Duchesneae Indicae, Herba Solani Lyrati, Herba Solani Nigri decoct with water secondary, first time adds water by 15 times of medical material weight, decoct 2 hours, second time adds water by 10 times of medical material weight, decocts 1 hour, merge extractive liquid, filter, filtrate is concentrated into relative density 1.00-1.18 (55 DEG C); Radix Salviae Miltiorrhizae extracts three times, and first time press 8 extraordinarily ethanol of medical material weight, and reflux, extract, 1.5 hours, filters, recovery ethanol; Second time press 8 extraordinarily 50% ethanol of medical material weight, and reflux, extract, 1.5 hours filters, recovery ethanol; Third time adds water by 10 times of medical material weight, and decoct 2 hours, filtrate and alcohol concentrated solution merge, and are concentrated into relative density 1.01-1.15 (55 DEG C); Above-mentioned water, alcohol concentrated solution are merged, is spray dried to dried cream powder; Obtain dry thing A.
4. according to the Chinese medicine composition of a kind of Therapeutic cancer in claims 1 to 3 described in any one, it is characterized in that: affiliated medicine is also containing the acceptable adjuvant of pharmaceutics.
5. the Chinese medicine composition of a kind of Therapeutic cancer according to claim 4, is characterized in that: the acceptable adjuvant of described pharmaceutics be selected from starch, microcrystalline Cellulose, sucrose, aspartame, dextrin, lactose, Icing Sugar, glucose, sodium chloride, Carboxymethyl cellulose sodium, crospolyvinylpyrrolidone, magnesium stearate, micropowder silica gel, vitamin C, cysteine, citric acid and sodium sulfite any one or a few.
6. the Chinese medicine composition of a kind of Therapeutic cancer according to claim 4, is characterized in that: the dosage form of described Chinese medicine composition is peroral dosage form, comprises pill, tablet, capsule or oral liquid.
7. a preparation method for the Chinese medicine composition of Therapeutic cancer, takes the Radix Astragali 678 parts, Radix Angelicae Sinensis 226 parts, Herba Solani Lyrati 678 parts, Herba Solani Nigri 678 parts, Radix Salviae Miltiorrhizae 226 parts, Herba Scutellariae Barbatae 678 parts, Herba Duchesneae Indicae 339 parts, Radix Curcumae 226 parts.Radix Angelicae Sinensis, the Radix Astragali, Radix Curcumae, Herba Scutellariae Barbatae, Herba Duchesneae Indicae, Herba Solani Lyrati, Herba Solani Nigri decoct with water secondary, and first time decocts 2 hours, and second time decocts 1 hour, merge extractive liquid, and filter, filtrate is concentrated into relative density 1.00-1.18 (55 DEG C); Radix Salviae Miltiorrhizae extracts three times, and first time adds alcohol reflux 1.5 hours, filters, and reclaims ethanol; Second time adds ethanol, reflux, extract, 1.5 hours, filters, and reclaims ethanol; Third time adds water, and decoct 2 hours, filtrate and alcohol concentrated solution merge, and are concentrated into relative density 1.01-1.15 (55 DEG C); Above-mentioned water, alcohol concentrated solution are merged, is spray dried to dried cream powder, obtains dry thing A.
8. the preparation method of the Chinese medicine composition of a kind of Therapeutic cancer according to claim 7, it is characterized in that: Radix Angelicae Sinensis, the Radix Astragali, Radix Curcumae, Herba Scutellariae Barbatae, Herba Duchesneae Indicae, Herba Solani Lyrati, Herba Solani Nigri decoct with water secondary, first time adds water by 15 times of medical material weight, decoct 2 hours, second time adds water by 10 times of medical material weight, decocts 1 hour, merge extractive liquid, filter, filtrate is concentrated into relative density 1.00-1.18 (55 DEG C); Radix Salviae Miltiorrhizae extracts three times, and first time press 8 extraordinarily ethanol of medical material weight, and reflux, extract, 1.5 hours, filters, recovery ethanol; Second time press 8 extraordinarily 50% ethanol of medical material weight, and reflux, extract, 1.5 hours filters, recovery ethanol; Third time adds water by 10 times of medical material weight, and decoct 2 hours, filtrate and alcohol concentrated solution merge, and are concentrated into relative density 1.01.1.15 (55 DEG C); Above-mentioned water, alcohol concentrated solution are merged, is spray dried to dried cream powder, obtains dry thing A.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104888149A (en) * | 2015-06-27 | 2015-09-09 | 刘今方 | Drug for treating cervical cancer and preparation method for drug |
| CN105641200A (en) * | 2016-01-13 | 2016-06-08 | 朱立良 | Selenium-enriched anti-cancer composition oral liquid and preparation method and application thereof |
| CN107519329A (en) * | 2016-06-20 | 2017-12-29 | 邓泽潭 | A kind of traditional Chinese medicine for oral administration for treating the cancer of the esophagus |
| CN113640434A (en) * | 2020-11-30 | 2021-11-12 | 天津中新药业集团股份有限公司隆顺榕制药厂 | Construction method and application of high performance liquid chromatography fingerprint of Zilongjin tablets |
-
2013
- 2013-06-26 CN CN201310259543.0A patent/CN104248741A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104888149A (en) * | 2015-06-27 | 2015-09-09 | 刘今方 | Drug for treating cervical cancer and preparation method for drug |
| CN104888149B (en) * | 2015-06-27 | 2019-01-22 | 刘今方 | The drug and its preparation process for treating cervical carcinoma |
| CN105641200A (en) * | 2016-01-13 | 2016-06-08 | 朱立良 | Selenium-enriched anti-cancer composition oral liquid and preparation method and application thereof |
| CN107519329A (en) * | 2016-06-20 | 2017-12-29 | 邓泽潭 | A kind of traditional Chinese medicine for oral administration for treating the cancer of the esophagus |
| CN113640434A (en) * | 2020-11-30 | 2021-11-12 | 天津中新药业集团股份有限公司隆顺榕制药厂 | Construction method and application of high performance liquid chromatography fingerprint of Zilongjin tablets |
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Application publication date: 20141231 |