CN105878712A - Traditional Chinese medicinal composition with efficacy of invigorating heart to tranquilize mind and preparation method of traditional Chinese medicinal composition - Google Patents
Traditional Chinese medicinal composition with efficacy of invigorating heart to tranquilize mind and preparation method of traditional Chinese medicinal composition Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicinal composition with the efficacy of invigorating the heart to tranquilize the mind and a preparation method of the traditional Chinese medicinal composition, belonging to the field of modernization of the Chinese traditional medicine. The traditional Chinese medicinal composition is prepared from the following medicinal materials in parts by weight: 200 parts of rhizoma rehmanniae, 50 parts of radix ophiopogonis, 25 parts of poria cocos, 25 parts of radix scrophulariae, 50 parts of radix asparagi, 25 parts of radix codonopsis, 50 parts of the fruits of Chinese magnoliavine, 50 parts of radix angelica sinensis, 25 parts of processed radix polygalae, 25 parts of radix platycodi, 50 parts of stir-baked spina date seeds, 50 parts of semen boitae, 25 parts of radix salviae miltiorrhizae, 25 parts of licorice root baked with honey, and 10 parts of cinnabar. According to the research result on the physicochemical properties and pharmacological effects of the ingredients in the medicinal materials, the preparation method of the traditional Chinese medicinal composition containing the reasonable and stable medicinal materials is obtained. With the adoption of the technical scheme, the prepared medicine is stable and controllable in quality, the curative effects of the prepared medicine are obviously improved compared with those of the existing compositions sold in the market, the taking dosage of the patient is reduced, and therefore, the traditional Chinese medicinal composition has obvious economic and social benefits.
Description
Technical field
The present invention relates to Chinese medicine composition of a kind of heart tonifying and tranquilizing and preparation method thereof, belong to the modernization of Chinese medicine
Field.
Background technology
Reinforcing the heart sheet nourishing YIN and benefiting blood, heart tonifying and tranquilizing.For cardiopalmus Mental fatigue, the insomnia forgetfulness of deficiency of YIN insufficiency of blood,
Constipation with dry stool, aphtha of the mouth and tongue, the few tongue of red tongue, thready and rapid pulse.It is clinically used for the chronic disease of insomnia forgetfulness
Disease patient.
When running into the disease of the mind uneasinesses such as nervous cardiopalmus, insomnia forgetfulness, doctor trained in Western medicine is many with tranquilizer
Treat with sleeping pill etc.；But the untoward reaction of these medicines is the biggest, and may produce
Dependence effect.And the traditional Chinese medical science thinks that the pathogenic factor of insomnia is a lot, but nothing more than deficiency and excess two kinds.Wherein
Deficiency syndrome many genus deficiency of YIN-blood, the moon declines the excess of YANG and has difficulty in going to sleep.Prescription be often also adopted by effect substantially and
The medicine that untoward reaction is less.Reinforcing the heart sheet is exactly to treat the Chinese patent medicine that cardiopalmus is had palpitation, insomnia is slept less.
Mainly form with the medicine of nourishing YIN and benefiting blood, it is adaptable to insomnia and dreamful sleep, dysphoria, severe palpitation,
The treatment of the diseases such as hypomnesis.Treatment the deficiency of YIN and uneasy method.Disease sees palpitation and being susceptible to fright,
Forgetful insomnia, absentminded, many nocturnal emissions, aphtha of the mouth and tongue, constipation due to dry stool, the few tongue of red tongue, arteries and veins
Count accurately.
The prescription of reinforcing the heart sheet and preparation method be: Radix Rehmanniae 200g, 50g Radix Ophiopogonis, Poria 25g, Radix Scrophulariae
25g, Radix Asparagi 50g, Radix Codonopsis 25g, Fructus Schisandrae Chinensis 50g, Radix Angelicae Sinensis 50g, Radix Polygalae (system) 25g, Fructus Citri tangerinae
Stalk 25g, Semen Ziziphi Spinosae (stir-fry) 50g, Semen Platycladi 50g, Radix Salviae Miltiorrhizae 25g, Radix Glycyrrhizae (processed with honey) 25g, stone
Rhizoma Acori Graminei 25g, Cinnabaris 10g.Above ten Six-elements, Cinnabaris water flies or is ground into impalpable powder；Poria,
Radix Platycodonis, Radix Glycyrrhizae powder are broken into fine powder, sieve；Radix Rehmanniae, Radix Codonopsis, Radix Asparagi, boiling Radix Ophiopogonis secondary,
2 hours for the first time, 1.5 hours for the second time, collecting decoction, filter, filtrate is concentrated into paste；
Eight tastes such as remaining Semen Platycladi, are ground into coarse powder, (attached with the percolation under extractum item according to fluid extract
Record page 17), use 60% ethanol as solvent, after impregnating 24 hours, carry out percolation, collect liquid of filtering,
Reclaim ethanol, and be concentrated into paste；Take above-mentioned fine powder to mix with thick paste, make granule, be dried,
Tabletted, sugar coating, to obtain final product.
Summary of the invention
First technical problem that the invention solves the problems that is to provide the Chinese medicine composition of a kind of heart tonifying and tranquilizing.
Another technical problem that the invention solves the problems that is to provide the preparation method of above-mentioned Chinese medicine composition.
For achieving the above object, the present invention is by the following technical solutions；
A kind of Chinese medicine composition of heart tonifying and tranquilizing, its active component is made up of the raw material of following parts by weight:
Radix Rehmanniae 200 parts, Radix Ophiopogonis 50 parts, 25 parts of Poria, Radix Scrophulariae 25 parts, Radix Asparagi 50 parts, Radix Codonopsis 25
Part, Fructus Schisandrae Chinensis 50 parts, Radix Angelicae Sinensis 50 parts, Radix Polygalae (system) 25 parts, Radix Platycodonis 25 parts, Semen Ziziphi Spinosae (stir-fry) 50
Part, Semen Platycladi 50 parts, Radix Salviae Miltiorrhizae 25 parts, 25 parts of Radix Glycyrrhizae (processed with honey), 10 parts of Cinnabaris.
Described active component uses following method to prepare:
1, each raw material is weighed by proportioning raw materials；；Poria, Radix Platycodonis, Radix Glycyrrhizae powder are broken into fine powder, sieve；
Radix Rehmanniae, Radix Codonopsis, Radix Asparagi, boiling Radix Ophiopogonis secondary, 2 hours for the first time, 1.5 hours for the second time,
Collecting decoction, filters, and filtrate is concentrated into paste；Remaining Semen Platycladi etc., are ground into coarse powder, with 60%
Ethanol as solvent, carries out percolation after impregnating 24 hours, collect liquid of filtering, and reclaims ethanol, and is concentrated into thick
Paste；Take above-mentioned fine powder to mix with thick paste, make granule, be dried, obtain dried object A.
2, each raw material is weighed by proportioning raw materials；Cinnabaris water flies or is ground into impalpable powder；Poria, Radix Platycodonis,
Radix Glycyrrhizae powder is broken into fine powder, sieves；Radix Rehmanniae, Radix Codonopsis, Radix Asparagi, boiling Radix Ophiopogonis secondary, use for the first time
10 times amount soak by water 2 hours, second time 8 times amount soak by water 1.5 hours, collecting decoction, filtration,
Filtrate is concentrated into the thick paste of relative density 1.20-1.30 (55 DEG C)；Remaining Semen Platycladi etc., are ground into coarse powder,
It is 60% ethanol as solvent with the concentration of volume percent of 8 times amount, after impregnating 24 hours, carries out percolation,
Collection is filtered liquid, reclaims ethanol, and is concentrated into the thick paste of relative density 1.20-1.30 (55 DEG C)；Take above-mentioned
Fine powder mixes with thick paste, makes granule, is dried, obtains dried object A.
Described pharmaceutical composition is possibly together with the acceptable adjuvant of pharmaceutics.
The acceptable adjuvant of described pharmaceutics is selected from starch, microcrystalline Cellulose, sucrose, aspartame, paste
Essence, lactose, Icing Sugar, glucose, sodium chloride, Carboxymethyl cellulose sodium, crospolyvinylpyrrolidone,
Any one in magnesium stearate, micropowder silica gel, vitamin C, cysteine, citric acid and sodium sulfite
Plant or several.
The dosage form of described Chinese medicine composition is peroral dosage form, include but not limited to pill, tablet, capsule or
Oral liquid.The selection of dosage form and the consumption of adjuvant belong to prior art.
A kind of preparation method of the Chinese medicine composition of heart tonifying and tranquilizing:
Weigh Radix Rehmanniae 200 parts, Radix Ophiopogonis 50 parts, 25 parts of Poria, Radix Scrophulariae 25 parts, Radix Asparagi 50 parts,
Radix Codonopsis 25 parts, Fructus Schisandrae Chinensis 50 parts, Radix Angelicae Sinensis 50 parts, Radix Polygalae (system) 25 parts, Radix Platycodonis 25 parts, Ziziphi Spinosae
Core (stir-fry) 50 parts, Semen Platycladi 50 parts, Radix Salviae Miltiorrhizae 25 parts, 25 parts of Radix Glycyrrhizae (processed with honey), 10 parts of Cinnabaris.
Cinnabaris water flies or is ground into impalpable powder；Poria, Radix Platycodonis, Radix Glycyrrhizae powder are broken into fine powder, sieve；Radix Rehmanniae, party
Ginseng, Radix Asparagi, boiling Radix Ophiopogonis secondary, 2 hours for the first time, 1.5 hours for the second time, collecting decoction,
Filtering, filtrate is concentrated into paste；Remaining Semen Platycladi etc., are ground into coarse powder, use 60% ethanol as solvent,
Carry out percolation after impregnating 24 hours, collect liquid of filtering, reclaim ethanol, and be concentrated into paste；Take above-mentioned
Fine powder mixes with thick paste, makes granule, is dried, obtains dried object A.
Preferably preparation method is: weigh each raw material by proportioning raw materials；Cinnabaris water flies or is ground into impalpable powder；
Poria, Radix Platycodonis, Radix Glycyrrhizae powder are broken into fine powder, sieve；Radix Rehmanniae, Radix Codonopsis, Radix Asparagi, boiling Radix Ophiopogonis two
Secondary, for the first time with 10 times amount soak by water 2 hours, second time 8 times amount soak by water 1.5 hours, merging
Decocting liquid, filters, and filtrate is concentrated into the thick paste of relative density 1.20-1.30 (55 DEG C)；Remaining Semen Platycladi etc.,
It is ground into coarse powder, is 60% ethanol as solvent with the concentration of volume percent of 8 times amount, impregnate 24 hours
After carry out percolation, collect liquid of filtering, reclaim ethanol, and be concentrated into relative density 1.20-1.30 (55 DEG C)
Thick paste；Take above-mentioned fine powder to mix with thick paste, make granule, be dried, obtain dried object A.
The preparation of the Chinese medicine composition of a kind of heart tonifying and tranquilizing, said preparation adds with above-mentioned active constituents of medicine and is used as medicine
The acceptable adjuvant of agent, makes the acceptable dosage form of pharmaceutics.Utilize the Chinese medicine composition that the present invention obtains
When the active component of thing prepares the various dosage form of required medicine, can be according to the conventional production of art of pharmacy
Prepared by method.As mixed with one or more carriers by this active component, then make corresponding dosage form.
The invention have the advantage that the present invention uses theory of Chinese medical science to analyze prescription composition, contained by each flavour of a drug
The physicochemical property of composition and pharmacological action, research has obtained the preparation method of reasonable, stable active component.
Use technical scheme, on duty go out stable and controllable for quality, curative effect compared with the existing commercial dosage forms
Significantly improve, patient's taking dose reduce pharmaceutical preparation, there is significant economic and social benefit.
Describe technical solution of the present invention by the following examples in detail, do not limit the enforcement of the present invention with this
Scope.
Detailed description of the invention
Embodiment 1: prepare Chinese medicine extract
One, prescription: Radix Rehmanniae 200g, 50g Radix Ophiopogonis, Poria 25g, Radix Scrophulariae 25g, Radix Asparagi 50g,
Radix Codonopsis 25g, Fructus Schisandrae Chinensis 50g, Radix Angelicae Sinensis 50g, Radix Polygalae (system) 25g, Radix Platycodonis 25g, Semen Ziziphi Spinosae (stir-fry) 50g,
Semen Platycladi 50g, Radix Salviae Miltiorrhizae 25g, Radix Glycyrrhizae (processed with honey) 25g, Cinnabaris 10g.
Two, preparation method:
Cinnabaris water flies or is ground into impalpable powder；Poria, Radix Platycodonis, Radix Glycyrrhizae powder are broken into fine powder, sieve；Radix Rehmanniae,
Radix Codonopsis, Radix Asparagi, boiling Radix Ophiopogonis secondary, for the first time with 10 times amount soak by water 2 hours, for the second time
With 8 times amount soak by water 1.5 hours, collecting decoction, filtering, filtrate is concentrated into relative density 1.20-1.30
The thick paste of (55 DEG C)；Remaining Semen Platycladi etc., are ground into coarse powder, with the concentration of volume percent of 8 times amount
It is 60% ethanol as solvent, after impregnating 24 hours, carries out percolation, collect liquid of filtering, reclaim ethanol, and dense
It is reduced to the thick paste of relative density 1.20-1.30 (55 DEG C)；Take above-mentioned fine powder to mix with thick paste, make granule,
It is dried, obtains dried object A and amount to 267g.
Embodiment 2: prepare Chinese medicine extract
One, prescription: Radix Rehmanniae 130kg, 32.5kg Radix Ophiopogonis, Poria 16.25kg, Radix Scrophulariae 16.25kg,
Radix Asparagi 32.5kg, Radix Codonopsis 16.25kg, Fructus Schisandrae Chinensis 32.5kg, Radix Angelicae Sinensis 32.5kg, Radix Polygalae (system) 16.25kg,
Radix Platycodonis 16.25kg, Semen Ziziphi Spinosae (stir-fry) 32.5kg, Semen Platycladi 32.5kg, Radix Salviae Miltiorrhizae 16.25g, Radix Glycyrrhizae (processed with honey)
16.25kg, Cinnabaris 6.5kg.
Two, preparation method:
Cinnabaris water flies or is ground into impalpable powder；Poria, Radix Platycodonis, Radix Glycyrrhizae powder are broken into fine powder, sieve；Radix Rehmanniae,
Radix Codonopsis, Radix Asparagi, boiling Radix Ophiopogonis secondary, for the first time with 10 times amount soak by water 2 hours, for the second time
With 8 times amount soak by water 1.5 hours, collecting decoction, filtering, filtrate is concentrated into relative density 1.20-1.30
The thick paste of (55 DEG C)；Remaining Semen Platycladi etc., are ground into coarse powder, with the concentration of volume percent of 8 times amount
It is 60% ethanol as solvent, after impregnating 24 hours, carries out percolation, collect liquid of filtering, reclaim ethanol, and dense
It is reduced to the thick paste of relative density 1.20-1.30 (55 DEG C)；Take above-mentioned fine powder to mix with thick paste, make granule,
It is dried, obtains dried object A and amount to 173.6kg.
Embodiment 3: prepare tablet
The active component 100g that embodiment 1 obtains, adds microcrystalline Cellulose 40g, cross-linked pvp 7g, tabletting,
Obtain tablet, every tablet weight 0.35g.
Embodiment 4: prepare capsule
The active component 1000g that embodiment 1 obtains, adds starch 250g, encapsulating capsule, obtains capsule, often
Grain weight 0.50g.
Embodiment 5: zoopery
One, materials and methods:
ANSHEN BUXIN WAN (lot number 100807), Pingshan, Foochow pharmaceutical factory provides.
Sedative jujube kernel capsule (lot number 110427), the Chongqing pharmaceutical factory of traditional Chinese medicine provides.
Reinforcing the heart sheet (lot number 110816), Longshunrong Pharmaceutical Factory, Tianjin Zhongxin Pharmaceutical Group Co., Ltd
Product.
Animal: ICR mice, 18-22g, is provided by Beijing Vital River Experimental Animals Technology Co., Ltd.,
Credit number: SCXK (capital) 2002-2003.
Take healthy ICR mice 60, random point 6 groups, often organize 10.Test sets: matched group (is given
Normal saline 20ml/kg)；Extract high and low dose group, reinforcing the heart sheet high and low dose group；Positive right
According to group sedative jujube kernel capsule 0.4g/kg.All it is made into 20ml suspension, by body weight with normal saline
0.2ml/10g is to mice ig.After being administered 50 minutes, mice puts the mice that the multiplex instrument of pharmacology physiology connects
In activity inventory box, after adapting to 3 minutes, start mice activity number of times in record 5 pulmonary abscess.
Two, the results are shown in Table 1.
Table 1
| Group | Dosage (g/kg) | 5 minutes movable number of times |
| Matched group | 105.3±39.5 | |
| Extract high dose group | 7.2 | 48.7±21.7*** |
| Extract low dose group | 1.8 | 88.3±31.8 |
| Reinforcing the heart sheet | 7.2 | 62.2±24.3** |
| Reinforcing the heart sheet | 1.8 | 91.0±23.4 |
| Sedative jujube kernel capsule group | 0.4 | 60.1±16.9** |
T checks: * * p ＜ 0.01, * * * p ＜ 0.001 compared with matched group, and extract and tablet height agent are described
Amount and sedative jujube kernel capsule all have sedation, and sedation is better than reinforcing the heart sheet.
Claims (8)
1. a Chinese medicine composition for heart tonifying and tranquilizing, its active component is by following parts by weight
Raw material is made: Radix Rehmanniae 200 parts, Radix Ophiopogonis 50 parts, 25 parts of Poria, Radix Scrophulariae 25 part, day
Winter 50 parts, Radix Codonopsis 25 parts, Fructus Schisandrae Chinensis 50 parts, Radix Angelicae Sinensis 50 parts, Radix Polygalae (system) 25 parts,
Radix Platycodonis 25 parts, Semen Ziziphi Spinosae (stir-fry) 50 parts, Semen Platycladi 50 parts, Radix Salviae Miltiorrhizae 25 parts, Radix Glycyrrhizae (honey
Process) 25 parts, 10 parts of Cinnabaris.
A kind of Chinese medicine composition treating heart tonifying and tranquilizing the most according to claim 1, its
It is characterised by that described active component uses following method to prepare: Cinnabaris water flies or pulverizes poling
Fine powder；Poria, Radix Platycodonis, Radix Glycyrrhizae powder are broken into fine powder, sieve；Radix Rehmanniae, Radix Codonopsis, Radix Asparagi, wheat
Winter boiling secondary, 2 hours for the first time, 1.5 hours for the second time, collecting decoction, filter,
Filtrate is concentrated into paste；Remaining Semen Platycladi etc., are ground into coarse powder, make molten with 60% ethanol
Agent, carries out percolation after impregnating 24 hours, collect liquid of filtering, and reclaims ethanol, and is concentrated into thick paste
Shape；Take above-mentioned fine powder to mix with thick paste, make granule, be dried, obtain dried object A.
A kind of Chinese medicine composition treating heart tonifying and tranquilizing the most according to claim 2, its
It is characterised by: Cinnabaris water flies or is ground into impalpable powder；Poria, Radix Platycodonis, Radix Glycyrrhizae powder are broken into fine powder,
Sieve；Radix Rehmanniae, Radix Codonopsis, Radix Asparagi, boiling Radix Ophiopogonis secondary, for the first time with 10 times amount water
Decoct 2 hours, second time 8 times amount soak by water 1.5 hours, collecting decoction, filter, filter
Liquid is concentrated into the thick paste of relative density 1.20-1.30 (55 DEG C)；Remaining Semen Platycladi etc., are ground into
Coarse powder, is 60% ethanol as solvent with the concentration of volume percent of 8 times amount, impregnates 24 hours
After carry out percolation, collect liquid of filtering, reclaim ethanol, and be concentrated into relative density 1.20-1.30 (55 DEG C)
Thick paste；Take above-mentioned fine powder to mix with thick paste, make granule, be dried, obtain dried object A.
4. treat heart tonifying and tranquilizing according to a kind of in any of the one of claims 1 to 3
Chinese medicine composition, it is characterised in that: affiliated medicine is possibly together with the acceptable adjuvant of pharmaceutics.
A kind of Chinese medicine composition treating heart tonifying and tranquilizing the most according to claim 4, its
Be characterised by: the acceptable adjuvant of described pharmaceutics selected from starch, microcrystalline Cellulose, sucrose,
Aspartame, dextrin, lactose, Icing Sugar, glucose, sodium chloride, Carboxymethyl cellulose sodium,
Crospolyvinylpyrrolidone, magnesium stearate, micropowder silica gel, vitamin C, cysteine,
Any one or a few in citric acid and sodium sulfite.
A kind of Chinese medicine composition treating heart tonifying and tranquilizing the most according to claim 4, its
It is characterised by: the dosage form of described Chinese medicine composition is peroral dosage form, including pill, tablet, glue
Capsule or oral liquid.
7. the preparation method of the Chinese medicine composition treating heart tonifying and tranquilizing, it is characterised in that:
Weigh Radix Rehmanniae 200 parts, Radix Ophiopogonis 50 parts, 25 parts of Poria, Radix Scrophulariae 25 parts, Radix Asparagi 50
Part, Radix Codonopsis 25 parts, Fructus Schisandrae Chinensis 50 parts, Radix Angelicae Sinensis 50 parts, Radix Polygalae (system) 25 parts, Radix Platycodonis 25
Part, Semen Ziziphi Spinosae (stir-fry) 50 parts, Semen Platycladi 50 parts, Radix Salviae Miltiorrhizae 25 parts, 25 parts of Radix Glycyrrhizae (processed with honey),
10 parts of Cinnabaris.Cinnabaris water flies or is ground into impalpable powder；Poria, Radix Platycodonis, Radix Glycyrrhizae powder are broken into carefully
Powder, sieves；Radix Rehmanniae, Radix Codonopsis, Radix Asparagi, boiling Radix Ophiopogonis secondary, 2 hours for the first time,
1.5 hours for the second time, collecting decoction, filter, filtrate is concentrated into paste；Remaining Semen Platycladi
Deng, it is ground into coarse powder, uses 60% ethanol as solvent, after impregnating 24 hours, carry out percolation, receive
Collect liquid of filtering, reclaim ethanol, and be concentrated into paste；Take above-mentioned fine powder to mix with thick paste, make
Granule, is dried, obtains dried object A.
One according to claim 1 the most according to claim 7 treats reinforcing the heart
Traditional Chinese medicine for soothing nerves compositions, it is characterised in that: weigh Radix Rehmanniae 200 parts, Radix Ophiopogonis 50 parts, Fu
Siberian cocklebur 25 parts, Radix Scrophulariae 25 parts, Radix Asparagi 50 parts, Radix Codonopsis 25 parts, Fructus Schisandrae Chinensis 50 parts, when
Return 50 parts, Radix Polygalae (system) 25 parts, Radix Platycodonis 25 parts, Semen Ziziphi Spinosae (stir-fry) 50 parts, Semen Platycladi 50
Part, Radix Salviae Miltiorrhizae 25 parts, 25 parts of Radix Glycyrrhizae (processed with honey), 10 parts of Cinnabaris.Cinnabaris water flies or is ground into
Impalpable powder；Poria, Radix Platycodonis, Radix Glycyrrhizae powder are broken into fine powder, sieve；Radix Rehmanniae, Radix Codonopsis, Radix Asparagi,
Boiling Radix Ophiopogonis secondary, for the first time with 10 times amount soak by water 2 hours, for the second time with 8 times
Amount soak by water 1.5 hours, collecting decoction, filter, filtrate is concentrated into relative density 1.20-1.30
The thick paste of (55 DEG C)；Remaining Semen Platycladi etc., are ground into coarse powder, with the volume basis of 8 times amount
Specific concentration is 60% ethanol as solvent, carries out percolation after impregnating 24 hours, collects liquid of filtering, and returns
Receive ethanol, and be concentrated into the thick paste of relative density 1.20-1.30 (55 DEG C)；Take above-mentioned fine powder with
Thick paste mixes, and makes granule, is dried, obtains dried object A.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107349348A (en) * | 2017-06-20 | 2017-11-17 | 重庆壹通堂健康管理咨询有限公司 | A kind of Chinese medicine preparation of bushing |
| CN108478704A (en) * | 2018-06-28 | 2018-09-04 | 习水县中医院 | Heart spleen giving young employees remedial-courses in general knowledge and vocational skills Chinese medicine composition and preparation method thereof |
-
2014
- 2014-12-12 CN CN201410804309.6A patent/CN105878712A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107349348A (en) * | 2017-06-20 | 2017-11-17 | 重庆壹通堂健康管理咨询有限公司 | A kind of Chinese medicine preparation of bushing |
| CN108478704A (en) * | 2018-06-28 | 2018-09-04 | 习水县中医院 | Heart spleen giving young employees remedial-courses in general knowledge and vocational skills Chinese medicine composition and preparation method thereof |
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Application publication date: 20160824 |