CN1961928A - Blood circulation-activating stasis-removing medicament for treating blood stasis syndrome and preparation process thereof - Google Patents
Blood circulation-activating stasis-removing medicament for treating blood stasis syndrome and preparation process thereof Download PDFInfo
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- CN1961928A CN1961928A CN 200510022052 CN200510022052A CN1961928A CN 1961928 A CN1961928 A CN 1961928A CN 200510022052 CN200510022052 CN 200510022052 CN 200510022052 A CN200510022052 A CN 200510022052A CN 1961928 A CN1961928 A CN 1961928A
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Abstract
The present invention provides a medicament for activating blood circulation and removing stasis, and its preparing process, wherein the raw materials include achyranthes and cyathula root, Bupleurum root, root of ballon flower, bitter orange, Chinese angelica root and dried rehmannia root. The medicament can be used for treating ischemic heart disease, acute myocardiac infarction, cardiomyopathy, cerebral thrombus, cerebral arteriosclerosis, transient cerebral ischemia, rheumatic heart disease, coronary heart disease, brain damage sequelae, epilepsy and dementia preaecox.
Description
Technical field the present invention relates to a kind of activating blood and removing stasis drug for the treatment of syndrome of blood stasis and preparation method thereof.Belong to pharmaceutical sanitary field.
The blood that the background technology a variety of causes causes follows that row is unusual, blood constituent changes, the pathological changes of venation own and blood oozing from the body openings or subcuta neous tissue be for outside the arteries and veins, all can cause blood flow retardance cohesion, accumulates inside and outside sering, and forms syndrome of blood stasis.Blood stasis is that human body is subjected to after the paathogenic factor effect formed pathological product in lysis, can directly act on a certain internal organs of human body again after it forms and multiple disease takes place.Clinically, syndrome of blood stasis is found in the dissimilar of multiple disease and different onset among the stage.The liver pulmonary congestion of common clinically ischemic heart desease, acute myocardial infarction, cardiomyopathy, myocarditis, cerebral thrombosis, cerebral arteriosclerosis, transient ischemic attack, rheumatic heart disease and heart failure, pulmonary heart disease, cerebral concussion sequela, epilepsy, schizophrenia etc. are belonged to blood stasis internal resistance person.
Treating cardiovascular and cerebrovascular disease, nephropathy, hepatopathy, nerve and psychotic disorder person in the Chinese patent medicine at present for oral administration has over one hundred kind, but its curative effect is not obvious.
Summary of the invention the object of the invention first purpose is to provide the medicine of the treatment syndrome of blood stasis with blood circulation promoting and blood stasis dispelling function.Another object of the present invention is to the activating blood and removing stasis drug of treatment syndrome of blood stasis is prepared into acceptable oral capsule, soft capsule, granule, sheet, fuse, chewable tablet, dispersible tablet, pill, oral liquid, syrup on the pharmaceutics.
The present invention uses the activating blood and resolving stasis and treating rule, forms through the screening prescription according to the theory of Chinese medicine.This medicine has been selected Radix Cyathulae, Radix Bupleuri, Radix Platycodonis, Fructus Aurantii and Radix Angelicae Sinensis, the Radix Rehmanniae for use on the basis of blood circulation promoting and blood stasis dispelling, regulating QI to relieve pain, given prominence to the lifting mechanism of qi, a surname's venting QI-blood has not been hindered blood with conditioning viscera function and blood stasis dispelling, and reaches the purpose of treatment syndrome of blood stasis.
First purpose of the present invention realizes by following steps.
Each flavour of a drug is formed with following weight part ratio:
Semen Persicae 38-58 Flos Carthami 30-42 Radix Angelicae Sinensis 30-42 Rhizoma Chuanxiong 14-22
Radix Rehmanniae 30-42 Radix Paeoniae Rubra 20-28 Radix Achyranthis Bidentatae 30-42 Radix Bupleuri 8-16
Fructus Aurantii 20-28 Radix Platycodonis 14-22 Radix Glycyrrhizae 8-16
The better weight part ratio of each flavour of a drug is:
Semen Persicae 43-53 Flos Carthami 33-39 Radix Angelicae Sinensis 33-39 Rhizoma Chuanxiong 16-20
Radix Rehmanniae 33-39 Radix Paeoniae Rubra 22-26 Radix Achyranthis Bidentatae 33-39 Radix Bupleuri 10-14
Fructus Aurantii 22-26 Radix Platycodonis 16-20 Radix Glycyrrhizae 10-14
Optimum weight part ratio of each flavour of a drug is:
Semen Persicae 48 Flos Carthamis 36 Radix Angelicae Sinensis 36 Rhizoma Chuanxiongs 18
The Radix Rehmanniae 36 Radix Paeoniae Rubra 24 Radix Achyranthis Bidentataes 36 Radix Bupleuri 12
Fructus Aurantii 24 Radix Platycodoniss 18 Radix Glycyrrhizaes 12
The preparation method of medicine of the present invention is
A, get Radix Angelicae Sinensis, Rhizoma Chuanxiong, Radix Bupleuri, Radix Paeoniae Rubra, Fructus Aurantii and be ground into coarse granule, add 10 times of water gagings, steam distillation extracts volatile oil, the volatile oil that extraction obtains adds beta-schardinger dextrin-and 10 times of water gagings of 4 times of amounts, and colloid mill grinds, make the Benexate Hydrochloride of volatile oil, drying, standby; Aqueous solution filters, and device is collected in addition, and is standby;
B, medicinal residues and Semen Persicae, Flos Carthami, the Radix Rehmanniae, Radix Achyranthis Bidentatae, Radix Platycodonis, Radix Glycyrrhizae decoct with water three times, add 7 times of water gagings respectively and decoct 3 hours; Adding 7 times of water gagings decocted 2 hours; Add 6 times of water gagings and decocted 1 hour, filter filtrate for later use;
C, B filtrate and the aqueous solution that extracts behind the volatile oil are merged, being concentrated into relative density is the clear paste of 1.10～1.14 (60 ℃), takes out, put coldly, add ethanol and make and contain the alcohol amount and reach 70%, leave standstill, filter, filtrate recycling ethanol, concentrate, dry, to obtain dried cream powder standby;
F, get the Benexate Hydrochloride of C gained dried cream powder, A gained volatile oil, according to medicine conventional formulation method, make acceptable oral capsule, soft capsule, granule, sheet, fuse, chewable tablet, dispersible tablet, pill, oral liquid, syrup on the pharmaceutics.
The present invention be directed to syndrome of blood stasis and carry out the activating blood and removing stasis drug of symptomatic treatment, have blood circulation promoting and blood stasis dispelling, the promoting the circulation of QI to relieve pain effect.Be applicable to blood-stasis internal-depression, headache or chest pain, interior-heat blurring of vision accompanied with oppressive feeling, insomnia and dreamful sleep, severe palpitation, impatience and irascibility.
The specific embodiment further elaborates the present invention below in conjunction with embodiment.
Embodiment one
Take by weighing raw material by following proportioning:
Semen Persicae 480g Flos Carthami 360g Radix Angelicae Sinensis 360g Rhizoma Chuanxiong 180g
Radix Rehmanniae 360g Radix Paeoniae Rubra 240g Radix Achyranthis Bidentatae 360g Radix Bupleuri 120g
Fructus Aurantii 240g Radix Platycodonis 180g Radix Glycyrrhizae 120g
Preparation method is as follows:
A, get Radix Angelicae Sinensis, Rhizoma Chuanxiong, Radix Bupleuri, Radix Paeoniae Rubra, Fructus Aurantii and be ground into coarse granule, add 10 times of water gagings, steam distillation 6 hours extracts volatile oil, extracts the volatile oil that obtains, beta-schardinger dextrin-and 10 times of water gagings of adding 4 times of amounts, colloid mill ground 30 minutes, made the Benexate Hydrochloride of volatile oil, 50 ℃ of dryings, cross 100 mesh sieves, standby; Aqueous solution filters, and device is collected in addition, and is standby;
B, medicinal residues and Semen Persicae, Flos Carthami, the Radix Rehmanniae, Radix Achyranthis Bidentatae, Radix Platycodonis, Radix Glycyrrhizae decoct with water three times, add 7 times of water gagings respectively and decoct 3 hours; Adding 7 times of water gagings decocted 2 hours; Add 6 times of water gagings and decocted 1 hour, filter filtrate for later use;
C, B filtrate and the aqueous solution that extracts behind the volatile oil are merged, being concentrated into relative density is the clear paste of 1.10～1.14 (60 ℃), takes out, put coldly, add ethanol and make and contain the alcohol amount and reach 70%, left standstill 48 hours, filter, decompression filtrate recycling ethanol, concentrating under reduced pressure, drying, to obtain dried cream powder standby;
D, get the Benexate Hydrochloride of C gained dried cream powder, A gained volatile oil, it is an amount of to add Aspartane 5g and dextrin, makes into 1000g, makes granule with 85% ethanol, 60～80 ℃ of dryings, and, promptly prepare the activating blood and removing stasis drug granule of treatment syndrome of blood stasis.
The present invention is brown granule; Feeble QI, it is sweet to distinguish the flavor of.
Embodiment two:
Take by weighing raw material by following proportioning:
Semen Persicae 480g Flos Carthami 360g Radix Angelicae Sinensis 360g Rhizoma Chuanxiong 180g
Radix Rehmanniae 360g Radix Paeoniae Rubra 240g Radix Achyranthis Bidentatae 360g Radix Bupleuri 120g
Fructus Aurantii 240g Radix Platycodonis 180g Radix Glycyrrhizae 120g
Preparation method is as follows:
A gets Radix Angelicae Sinensis, Rhizoma Chuanxiong, Radix Bupleuri, Radix Paeoniae Rubra, Fructus Aurantii and is ground into coarse granule, add 10 times of water gagings, steam distillation 6 hours extracts volatile oil, extracts the volatile oil that obtains, beta-schardinger dextrin-and 10 times of water gagings of adding 4 times of amounts, colloid mill ground 30 minutes, made the Benexate Hydrochloride of volatile oil, 50 ℃ of dryings, cross 100 mesh sieves, standby; Aqueous solution filters, and device is collected in addition, and is standby;
B medicinal residues and Semen Persicae, Flos Carthami, the Radix Rehmanniae, Radix Achyranthis Bidentatae, Radix Platycodonis, Radix Glycyrrhizae decoct with water three times, add 7 times of water gagings respectively and decoct 3 hours; Adding 7 times of water gagings decocted 2 hours; Add 6 times of water gagings and decocted 1 hour, filter filtrate for later use;
C merges B filtrate and the aqueous solution that extracts behind the volatile oil, and being concentrated into relative density is the clear paste of 1.10～1.14 (60 ℃), takes out, put coldly, add ethanol and make and contain the alcohol amount and reach 70%, left standstill 48 hours, filter, decompression filtrate recycling ethanol, concentrating under reduced pressure, drying, to obtain dried cream powder standby;
D, get the Benexate Hydrochloride of C gained dried cream powder, A gained volatile oil, add starch or dextrin is an amount of,, make granule with 85% ethanol, 60～80 ℃ of dryings are made 2000 capsules, the activating blood and removing stasis drug capsule of the syndrome of blood stasis that promptly obtains medical treatment.
Set forth below good effect of the present invention:
The present invention has promoting blood circulation and removing blood stasis and not blood trouble, liver-smoothing, qi-regulating and do not consume the characteristics of the moon, and does not have obvious side effect. Than clinical Treatment cardiovascular and cerebrovascular disease commonly used and the Chinese patent drug of Neuropsychic diseases such as coronary disease II number, pseudo-ginseng coronary disease sheet, No. 1, angina, GUANXIN DANSHEN PIAN, Danshen Root dropping ball etc., prescription are more reasonable, and therapeutic domain is more extensive. This medicine is at promoting blood circulation and removing blood stasis, regulating qi-flowing for relieving pain The basis on, selected radix cyathulae, radix bupleuri, balloonflower root, Fructus Aurantii and Radix Angelicae Sinensis, the dried rhizome of rehmannia, given prominence to the lifting mechanism of qi, a surname venting QI-blood with The conditioning viscera function and dispel the stasis of blood and do not hindered blood and reach the treatment syndrome of blood stasis purpose.
The present invention has promoting blood circulation and removing blood stasis, and the promoting qi circulation and relieving pain effect is to clinically common ischemic heart disease, acute myocardial infarction, cardiac muscle The liver pulmonary congestion of disease, myocarditis, cerebral thrombus, cerebral arteriovenous malformation, TIA, rheumatic heart disease and heart failure, the lung heart Disease, sequelae of traumatic brain injury, epilepsy, schizophrenia etc. belong to blood stasis internal resistance, depression and stagnation of QI person, and satisfied curative effect is arranged.
Claims (5)
1. activating blood and removing stasis drug for the treatment of syndrome of blood stasis is characterized in that each flavour of a drug forms with following weight part ratio:
Semen Persicae 38-58 Flos Carthami 30-42 Radix Angelicae Sinensis 30-42 Rhizoma Chuanxiong 14-22
Radix Rehmanniae 30-42 Radix Paeoniae Rubra 20-28 Radix Achyranthis Bidentatae 30-42 Radix Bupleuri 8-16
Fructus Aurantii 20-28 Radix Platycodonis 14-22 Radix Glycyrrhizae 8-16.
2. the activating blood and removing stasis drug of treatment syndrome of blood stasis as claimed in claim 1 is characterized in that the better weight part ratio of described each flavour of a drug is:
Semen Persicae 43-53 Flos Carthami 33-39 Radix Angelicae Sinensis 33-39 Rhizoma Chuanxiong 16-20
Radix Rehmanniae 33-39 Radix Paeoniae Rubra 22-26 Radix Achyranthis Bidentatae 33-39 Radix Bupleuri 10-14
Fructus Aurantii 22-26 Radix Platycodonis 16-20 Radix Glycyrrhizae 10-14.
3. the activating blood and removing stasis drug of treatment treatment syndrome of blood stasis as claimed in claim 2 is characterized in that optimum weight part ratio of described each flavour of a drug is:
Semen Persicae 48 is spent 36 Radix Angelicae Sinensis, 36 Rhizoma Chuanxiongs 18
The Radix Rehmanniae 36 Radix Paeoniae Rubra 24 Radix Achyranthis Bidentataes 36 Radix Bupleuri 12
Fructus Aurantii 24 Radix Platycodoniss 18 Radix Glycyrrhizaes 12.
4. preparation method as the activating blood and removing stasis drug of claim 1 and 2 and 3 described treatment syndrome of blood stasis is characterized in that:
A gets Radix Angelicae Sinensis, Rhizoma Chuanxiong, Radix Bupleuri, Radix Paeoniae Rubra, Fructus Aurantii and is ground into coarse granule, adds 10 times of water gagings, and steam distillation extracts volatile oil, the volatile oil that extraction obtains adds beta-schardinger dextrin-and 10 times of water gagings of 4 times of amounts, and colloid mill grinds, make the Benexate Hydrochloride of volatile oil, drying, standby; Aqueous solution filters, and device is collected in addition, and is standby;
B medicinal residues and Semen Persicae, Flos Carthami, the Radix Rehmanniae, Radix Achyranthis Bidentatae, Radix Platycodonis, Radix Glycyrrhizae decoct with water three times, add 7 times of water gagings respectively and decoct 3 hours; Adding 7 times of water gagings decocted 2 hours; Add 6 times of water gagings and decocted 1 hour, filter filtrate for later use;
C merges B filtrate and the aqueous solution that extracts behind the volatile oil, and being concentrated into relative density is the clear paste of 1.10～1.14 (60 ℃), takes out, and puts coldly, adds ethanol and makes and contain the alcohol amount and reach 70%, leaves standstill, filter, filtrate recycling ethanol, concentrate, dry, to obtain dried cream powder standby;
F gets the Benexate Hydrochloride of C gained dried cream powder, A gained volatile oil, according to medicine conventional formulation method, make acceptable oral capsule, soft capsule, granule, sheet, fuse, chewable tablet, dispersible tablet, pill, oral liquid, syrup on the pharmaceutics.
5. one kind as claim 1 and 2 and the activating blood and removing stasis drug of 3 and 4 described treatment syndrome of blood stasis and preparation method thereof, it is characterized in that blood circulation promoting and blood stasis dispelling, promoting the circulation of QI to relieve pain.Be applicable to blood-stasis internal-depression, headache or chest pain, interior-heat blurring of vision accompanied with oppressive feeling, insomnia and dreamful sleep, severe palpitation, impatience and irascibility.
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| CN102441104A (en) * | 2011-11-16 | 2012-05-09 | 淄博矿业集团有限责任公司中心医院 | Traditional Chinese medicine composition used for treating viral myocarditis, and preparation method thereof |
| CN102688337A (en) * | 2012-06-05 | 2012-09-26 | 张俊 | Medicinal liquor for regulating qi and blood |
| CN102836270A (en) * | 2012-08-29 | 2012-12-26 | 丰县时代工艺社 | Method for treating blood stasis syndrome headache |
| CN101874861B (en) * | 2009-12-08 | 2013-03-20 | 孟庆华 | Medicament for treating and preventing heart diseases |
| CN103877260A (en) * | 2014-04-01 | 2014-06-25 | 青岛市中心医院 | Traditional Chinese medicine preparation for treating congestive heart failure, and preparation method |
| CN104491194A (en) * | 2014-12-07 | 2015-04-08 | 肖玉翠 | Medicine for treating cardiopulmonary stasis blocking type rheumatic heart disease and preparation method of medicine |
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- 2005-11-10 CN CN 200510022052 patent/CN1961928A/en active Pending
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| CN102441104A (en) * | 2011-11-16 | 2012-05-09 | 淄博矿业集团有限责任公司中心医院 | Traditional Chinese medicine composition used for treating viral myocarditis, and preparation method thereof |
| CN102688337A (en) * | 2012-06-05 | 2012-09-26 | 张俊 | Medicinal liquor for regulating qi and blood |
| CN102836270A (en) * | 2012-08-29 | 2012-12-26 | 丰县时代工艺社 | Method for treating blood stasis syndrome headache |
| CN103877260A (en) * | 2014-04-01 | 2014-06-25 | 青岛市中心医院 | Traditional Chinese medicine preparation for treating congestive heart failure, and preparation method |
| CN104491194A (en) * | 2014-12-07 | 2015-04-08 | 肖玉翠 | Medicine for treating cardiopulmonary stasis blocking type rheumatic heart disease and preparation method of medicine |
| CN104623225A (en) * | 2015-01-04 | 2015-05-20 | 毕博学 | Traditional Chinese medicinepreparation for treating mental disordersassociated with craniocerebral trauma |
| CN104984038A (en) * | 2015-08-14 | 2015-10-21 | 陈双成 | Oral Chinese herb preparation treating post-traumatic brain syndrome and preparing method |
| CN105396066A (en) * | 2015-12-11 | 2016-03-16 | 钟柱林 | Pharmaceutical composition for treating schizophrenia and application thereof |
| CN105770736A (en) * | 2016-03-27 | 2016-07-20 | 王连运 | Medicament for assisting treatment of craniocerebral injuries |
| CN105833169A (en) * | 2016-03-30 | 2016-08-10 | 倪瑞云 | Medicine preparation for treating craniocerebral injury sequelae |
| CN106074842A (en) * | 2016-08-22 | 2016-11-09 | 曹蕊 | A kind of preparation method for cardiopathic Chinese medicine extract |
| CN106334164A (en) * | 2016-11-23 | 2017-01-18 | 张晓燕 | Traditional Chinese medicine composition for treating chest obstruction |
| CN108355028A (en) * | 2018-05-09 | 2018-08-03 | 陈竹涛 | A kind of Chinese medicine and preparation method thereof for treating myocardial infarction |
| CN108671105A (en) * | 2018-06-24 | 2018-10-19 | 陕西惠福药业有限公司 | A kind of solution Yu Shu god's capsules and preparation method thereof |
| CN108743883A (en) * | 2018-08-29 | 2018-11-06 | 河南中医药大学 | A kind of Chinese medicine for treating acne syndrome of blood stasis |
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Open date: 20070516 |