CN103784579A - Traditional Chinese medicinal composition for inflammation diminishing, eyesight improving and pain relieving, and preparation method thereof - Google Patents
Traditional Chinese medicinal composition for inflammation diminishing, eyesight improving and pain relieving, and preparation method thereof Download PDFInfo
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- CN103784579A CN103784579A CN201210430549.5A CN201210430549A CN103784579A CN 103784579 A CN103784579 A CN 103784579A CN 201210430549 A CN201210430549 A CN 201210430549A CN 103784579 A CN103784579 A CN 103784579A
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Abstract
The invention discloses a traditional Chinese medicinal composition for inflammation diminishing, eyesight improving and pain relieving, and a preparation method thereof, and belongs to the traditional Chinese medicine modernization field. The active components of the traditional Chinese medicinal composition for inflammation diminishing, eyesight improving and pain relieving are prepared by using the following raw materials, by weight, 80 parts of Abalone shell, 64 parts of Fructus Tribuli, 40 parts of Gentiana scabra Bunge, 40 parts of Fructus Leonuri, 320 parts of fresh lamb liver, 80 parts of radix bupleuri, 40 parts of Rhizoma Coptidis, 80 parts of Figwortflower Picrorhiza Rhizome, 80 parts of Radix Scutellariae, 40 parts of Amur Corktree Bark, 80 parts of cassia seed, 80 parts of Faeces Vespertilionum, 40 parts of green tangerine peel, 40 pars of Flos Buddlejae and 40 parts of Herb of Ramose Scouring Rush. The preparation method of reasonable and stable active components is obtained according to research results of the physical and chemical properties and the pharmacological effects of components contained in the raw materials. By adopting the above technical scheme, the quality of the prepared medicine is stable and controllable, the curative effect of the medicine is substantially stronger than that of dosage forms sold in the present market, and the administration dosage of a patient is reduced. The preparation method has substantial economic and social benefits.
Description
Technical field
The present invention relates to Chinese medicine composition of a kind of inflammation-dimishing and eye brightening pain relieving and preparation method thereof, belong to modern Chinese traditional medicine field.
Background technology
Show according to health ministry statistical data, China's adolescent myopia sickness rate is global the 1st, and sickness rate is 50%, and the blind causing due to myopia has according to statistics been only second to cataract, glaucoma and occupy the 3rd.Oneself is listed in one of three large diseases myopia.Myopia is positive, and serious harm is teen-age grows up healthy and sound.
Theory of Chinese medical science is thought, liver opening at eye, and impairment of blood by looking for a long time, eyes and whole body relationship between Zang-Fu and channels-collaterals are close, and the health care of eyes, except focusing on part, also will have whole body idea.Rhizoma Coptidis Hepar Caprae seu ovis sheet is the Chinese medicine of a kind of inflammation-dimishing and eye brightening pain relieving of selling in the market.Vigorous for liver-fire, unseeing, photophobia, bulbar conjunctiva polyp is climbed fine, epiphora induced by wind.There is purging liver-fire, removing toxic substances function of improving eyesight, tissue, the structure of protection eyes, maintain the normal usefulness of eyes rhodopsin, can prevent and treat myopia, nyctalopia, xerophthalmia, maintain twenty-twenty vision, prevent optic nerve degeneration.
Prescription and the method for making of Rhizoma Coptidis Hepar Caprae seu ovis sheet are: Concha Haliotidis 80g, puncture multitude 64g, Radix Gentianae 40g, Fructus Leonuri 40g, fresh sheep liver 320g, Radix Bupleuri 80g, Rhizoma Coptidis 40g, Rhizoma Picrorhizae 80g, Radix Scutellariae 80g, Cortex Phellodendri 40g, Semen Cassiae 80g, Faeces Vespertilionis 80g, Pericarpium Citri Reticulatae Viride 40g, Flos Buddlejae 40g, Herba Equiseti Hiemalis 40g.Concha Haliotidis is ground into fine powder, sieves.Fructus Tribuli, Radix Gentianae, Fructus Leonuri decoct with water secondary, and collecting decoction filters, and Herba Equiseti Hiemalis decocts with water once, filters.Radix Bupleuri adds warm macerating secondary after water boil, each 3 hours, filters.Merge above each liquid and be condensed into cream.Fresh sheep liver infusion process is extracted secondary, each 7 days, uses for the first time ethanol (O.05% adding hydrochloric acid by solvent) to extract, use for the second time 60% ethanol extraction, eight tastes, 60% ethanol percolate extraction such as all the other Rhizoma Picrorhizae, merge above ethanol extract, reclaim ethanol, be condensed into cream.Water, alcohol condensed cream are merged and add Concha Haliotidis powder and adjuvant, mix.Granulate, dry, tabletting 101O sheet, to obtain final product.
Summary of the invention
First technical problem that the present invention will solve is to provide a kind of Chinese medicine composition of inflammation-dimishing and eye brightening pain relieving.
Another technical problem that the present invention will solve is to provide the preparation method of above-mentioned Chinese medicine composition.
For achieving the above object, the present invention by the following technical solutions;
A Chinese medicine composition for inflammation-dimishing and eye brightening pain relieving, its active component is made up of the raw material of following parts by weight: 80 parts of Concha Haliotidis, 64 parts of puncture multitudes, 40 parts of Radix Gentianae, 40 parts of Fructus Leonuris, 320 parts of fresh sheep livers, 80 parts of Radix Bupleuri, 40 parts of Rhizoma Coptidis, 80 parts of Rhizoma Picrorhizae, 80 parts of Radix Scutellariaes, 40 parts of Cortex Phellodendris, 80 parts of Semen Cassiaes, 80 parts of Faeces Vespertilioniss, 40 parts, Pericarpium Citri Reticulatae Viride, 40 parts of Flos Buddlejaes, 40 parts of Herba Equiseties Hiemalis.
Described active component adopts following method to prepare:
1, Concha Haliotidis is ground into fine powder, sieves.Fructus Tribuli, Radix Gentianae, Fructus Leonuri decoct with water secondary, and collecting decoction filters, and Herba Equiseti Hiemalis decocts with water once, filters.Radix Bupleuri adds warm macerating secondary after water boil, each 3 hours, filters.Merge above each liquid and be condensed into cream.Fresh sheep liver infusion process is extracted secondary, uses for the first time ethanol (adding hydrochloric acid by solvent 0.05%) to extract, and uses for the second time 60% ethanol extraction, eight tastes, 60% ethanol percolate extraction such as all the other Rhizoma Picrorhizae, merge above ethanol extract, reclaim ethanol, be condensed into cream.Water, alcohol condensed cream are merged and add Concha Haliotidis powder and adjuvant, mix, obtain dry thing A.
2, take each raw material by proportioning raw materials; Concha Haliotidis is ground into fine powder, sieves, and Fructus Tribuli, Radix Gentianae, Fructus Leonuri decoct with water secondary, adds for the first time 10 times of water, decocts 2 hours, adds for the second time 8 times of water, decocts 1 hour, and collecting decoction, filters; Herba Equiseti Hiemalis adds 10 times of water, decocts 2 hours, filters; Radix Bupleuri adds warm macerating secondary after water boil, adds for the first time 10 times of water, adds for the second time 8 times of water, and each warm macerating 3 hours, filters; Merge above each liquid and be concentrated into relative density 1.20-1.30 (55 ℃); Fresh sheep liver infusion process is extracted secondary, use for the first time 3.5 times of 95% ethanol (adding hydrochloric acid by solvent 0.05%) to extract, use for the second time 2.5 times of 60% ethanol extraction, 7 times of 60% ethanol percolate extraction for eight tastes such as all the other Rhizoma Picrorhizae, merge above ethanol extract, reclaim ethanol, be concentrated into relative density 1.20-1.30 (55 ℃); Water, alcohol condensed cream are merged to adjuvants such as adding Concha Haliotidis powder and starch, dextrin, obtain dry thing A.
Described pharmaceutical composition also contains the acceptable adjuvant of pharmaceutics.
The acceptable adjuvant of described pharmaceutics is selected from any one or a few in starch, microcrystalline Cellulose, sucrose, aspartame, dextrin, lactose, Icing Sugar, glucose, sodium chloride, Carboxymethyl cellulose sodium, crospolyvinylpyrrolidone, magnesium stearate, micropowder silica gel, vitamin C, cysteine, citric acid and sodium sulfite.
The dosage form of described Chinese medicine composition is peroral dosage form, includes but not limited to pill, tablet, capsule or oral liquid.The selection of dosage form and the consumption of adjuvant all belong to prior art.
A kind of preparation method of Chinese medicine composition of inflammation-dimishing and eye brightening pain relieving:
Take 80 parts of Concha Haliotidis, 64 parts of puncture multitudes, 40 parts of Radix Gentianae, 40 parts of Fructus Leonuris, 320 parts of fresh sheep livers, 80 parts of Radix Bupleuri, 40 parts of Rhizoma Coptidis, 80 parts of Rhizoma Picrorhizae, 80 parts of Radix Scutellariaes, 40 parts of Cortex Phellodendris, 80 parts of Semen Cassiaes, 80 parts of Faeces Vespertilioniss, 40 parts, Pericarpium Citri Reticulatae Viride, 40 parts of Flos Buddlejaes, 40 parts of Herba Equiseties Hiemalis.Concha Haliotidis is ground into fine powder, sieves.Fructus Tribuli, Radix Gentianae, Fructus Leonuri decoct with water secondary, and collecting decoction filters, and Herba Equiseti Hiemalis decocts with water once, filters.Radix Bupleuri adds warm macerating secondary after water boil, each 3 hours, filters.Merge above each liquid and be condensed into cream.Fresh sheep liver infusion process is extracted secondary, uses for the first time ethanol (adding hydrochloric acid by solvent 0.05%) to extract, and uses for the second time 60% ethanol extraction, eight tastes, 60% ethanol percolate extraction such as all the other Rhizoma Picrorhizae, merge above ethanol extract, reclaim ethanol, be condensed into cream.Water, alcohol condensed cream are merged and add Concha Haliotidis powder and adjuvant, mix, obtain dry thing A.
Preferred preparation method is: take each raw material by proportioning raw materials; Concha Haliotidis is ground into fine powder, sieves, and Fructus Tribuli, Radix Gentianae, Fructus Leonuri decoct with water secondary, adds for the first time 10 times of water, decocts 2 hours, adds for the second time 8 times of water, decocts 1 hour, and collecting decoction, filters; Herba Equiseti Hiemalis adds 10 times of water, decocts 2 hours, filters; Radix Bupleuri adds warm macerating secondary after water boil, adds for the first time 10 times of water, adds for the second time 8 times of water, and each warm macerating 3 hours, filters; Merge above each liquid and be concentrated into relative density 1.20-1.30 (55 ℃); Fresh sheep liver infusion process is extracted secondary, use for the first time 3.5 times of 95% ethanol (adding hydrochloric acid by solvent 0.05%) to extract, use for the second time 2.5 times of 60% ethanol extraction, 7 times of 60% ethanol percolate extraction for eight tastes such as all the other Rhizoma Picrorhizae, merge above ethanol extract, reclaim ethanol, be concentrated into relative density 1.20-1.30 (55 ℃); Water, alcohol condensed cream are merged to adjuvants such as adding Concha Haliotidis powder and starch, dextrin, obtain dry thing A.
A preparation for the Chinese medicine composition of inflammation-dimishing and eye brightening pain relieving, said preparation adds the acceptable adjuvant of pharmaceutics with above-mentioned active constituents of medicine, makes the acceptable dosage form of pharmaceutics.While utilizing the various dosage form of the required medicine of active fraction preparation of the Chinese medicine composition that the present invention obtains, can be according to the conventional production method preparation in pharmaceutics field.As this active component is mixed with one or more carriers, then make corresponding dosage form.
Advantage of the present invention is: the present invention uses theory of Chinese medical science analysis prescription composition, and according to the physicochemical property of each flavour of a drug ingredient and pharmacological action, research has obtained the preparation method of reasonable, stable active component.Adopt technical scheme of the present invention, on duty go out stable and controllable for quality, curative effect significantly improves compared with existing commercially available dosage form, patient's taking dose reduce pharmaceutical preparation, there is significant economic and social benefit.
Describe by the following examples technical solution of the present invention in detail, do not limit practical range of the present invention with this.
The specific embodiment
Embodiment 1: prepare Chinese medicine extract
One, prescription: Concha Haliotidis 80g, puncture multitude 64g, Radix Gentianae 40g, Fructus Leonuri 40g, fresh sheep liver 320g, Radix Bupleuri 80g, Rhizoma Coptidis 40g, Rhizoma Picrorhizae 80g, Radix Scutellariae 80g, Cortex Phellodendri 40g, Semen Cassiae 80g, Faeces Vespertilionis 80g, Pericarpium Citri Reticulatae Viride 40g, Flos Buddlejae 40g, Herba Equiseti Hiemalis 40g.
Two, method for making:
Concha Haliotidis is ground into fine powder, sieves, and Fructus Tribuli, Radix Gentianae, Fructus Leonuri decoct with water secondary, adds for the first time 10 times of water, decocts 2 hours, adds for the second time 8 times of water, decocts 1 hour, and collecting decoction, filters; Herba Equiseti Hiemalis adds 10 times of water, decocts 2 hours, filters; Radix Bupleuri adds warm macerating secondary after water boil, adds for the first time 10 times of water, adds for the second time 8 times of water, and each warm macerating 3 hours, filters; Merge above each liquid and be concentrated into relative density 1.20-1.30 (55 ℃); Fresh sheep liver infusion process is extracted secondary, use for the first time 3.5 times of 95% ethanol (adding hydrochloric acid by solvent 0.05%) to extract, use for the second time 2.5 times of 60% ethanol extraction, 7 times of 60% ethanol percolate extraction for eight tastes such as all the other Rhizoma Picrorhizae, merge above ethanol extract, reclaim ethanol, be concentrated into relative density 1.20-1.30 (55 ℃); Water, alcohol condensed cream are merged to adjuvants such as adding Concha Haliotidis powder and starch, dextrin, obtain dry thing A and amount to 606g.
Embodiment 2: prepare tablet
The active component 100g that embodiment 1 obtains, adds microcrystalline Cellulose 40g, cross-linked pvp 7g, and tabletting, obtains tablet, every heavy 0.6g.
Embodiment 3: prepare capsule
The active component 1000g that embodiment 1 obtains, adds starch 250g, and encapsulating capsule, obtains capsule, every heavy 0.50g.
Claims (8)
1. a Chinese medicine composition for inflammation-dimishing and eye brightening pain relieving, its active component is made up of the raw material of following parts by weight: 80 parts of Concha Haliotidis, 64 parts of puncture multitudes, 40 parts of Radix Gentianae, 40 parts of Fructus Leonuris, 320 parts of fresh sheep livers, 80 parts of Radix Bupleuri, 40 parts of Rhizoma Coptidis, 80 parts of Rhizoma Picrorhizae, 80 parts of Radix Scutellariaes, 40 parts of Cortex Phellodendris, 80 parts of Semen Cassiaes, 80 parts of Faeces Vespertilioniss, 40 parts, Pericarpium Citri Reticulatae Viride, 40 parts of Flos Buddlejaes, 40 parts of Herba Equiseties Hiemalis.
2. according to the Chinese medicine composition of a kind of inflammation-dimishing and eye brightening pain relieving described in claim l, it is characterized in that described active component adopts following method to prepare: Concha Haliotidis is ground into fine powder, sieves.Fructus Tribuli, Radix Gentianae, Fructus Leonuri decoct with water secondary, and collecting decoction filters, and Herba Equiseti Hiemalis decocts with water once, filters.Radix Bupleuri adds warm macerating secondary after water boil, each 3 hours, filters.Merge above each liquid and be condensed into cream.Fresh sheep liver infusion process is extracted secondary, uses for the first time ethanol (adding hydrochloric acid by solvent 0.05%) to extract, and uses for the second time 60% ethanol extraction, eight tastes, 60% ethanol percolate extraction such as all the other Rhizoma Picrorhizae, merge above ethanol extract, reclaim ethanol, be condensed into cream.Water, alcohol condensed cream are merged and add Concha Haliotidis powder and adjuvant, mix, obtain dry thing A.
3. the Chinese medicine composition of a kind of inflammation-dimishing and eye brightening pain relieving according to claim 2, is characterized in that: Concha Haliotidis is ground into fine powder, sieves, and Fructus Tribuli, Radix Gentianae, Fructus Leonuri decoct with water secondary, add for the first time 10 times of water, decoct 2 hours, add for the second time 8 times of water, decoct 1 hour, collecting decoction, filters; Herba Equiseti Hiemalis adds 10 times of water, decocts 2 hours, filters; Radix Bupleuri adds warm macerating secondary after water boil, adds for the first time 10 times of water, adds for the second time 8 times of water, and each warm macerating 3 hours, filters; Merge above each liquid and be concentrated into relative density 1.20-1.30 (55 ℃); Fresh sheep liver infusion process is extracted secondary, use for the first time 3.5 times of 95% ethanol (adding hydrochloric acid by solvent 0.05%) to extract, use for the second time 2.5 times of 60% ethanol extraction, 7 times of 60% ethanol percolate extraction for eight tastes such as all the other Rhizoma Picrorhizae, merge above ethanol extract, reclaim ethanol, be concentrated into relative density 1.20-1.30 (55 ℃); Water, alcohol condensed cream are merged to adjuvants such as adding Concha Haliotidis powder and starch, dextrin, obtain dry thing A.
4. according to the Chinese medicine composition of a kind of inflammation-dimishing and eye brightening pain relieving described in any one in claims 1 to 3, it is characterized in that: affiliated medicine also contains the acceptable adjuvant of pharmaceutics.
5. the Chinese medicine composition of a kind of antiinflammatory pain relieving tomorrow according to claim 4, is characterized in that: the acceptable adjuvant of described pharmaceutics is selected from any one or a few in starch, microcrystalline Cellulose, sucrose, aspartame, dextrin, lactose, Icing Sugar, glucose, sodium chloride, Carboxymethyl cellulose sodium, crospolyvinylpyrrolidone, magnesium stearate, micropowder silica gel, vitamin C, cysteine, citric acid and sodium sulfite.
6. the Chinese medicine composition of a kind of inflammation-dimishing and eye brightening pain relieving according to claim 4, is characterized in that: the dosage form of described Chinese medicine composition is peroral dosage form, comprises pill, tablet, capsule or oral liquid.
7. a preparation method for the Chinese medicine composition of inflammation-dimishing and eye brightening pain relieving, is characterized in that: take 80 parts of Concha Haliotidis, 64 parts of puncture multitudes, 40 parts of Radix Gentianae, 40 parts of Fructus Leonuris, 320 parts of fresh sheep livers, 80 parts of Radix Bupleuri, 40 parts of Rhizoma Coptidis, 80 parts of Rhizoma Picrorhizae, 80 parts of Radix Scutellariaes, 40 parts of Cortex Phellodendris, 80 parts of Semen Cassiaes, 80 parts of Faeces Vespertilioniss, 40 parts, Pericarpium Citri Reticulatae Viride, 40 parts of Flos Buddlejaes, 40 parts of Herba Equiseties Hiemalis.Concha Haliotidis is ground into fine powder, sieves.Fructus Tribuli, Radix Gentianae, Fructus Leonuri decoct with water secondary, and collecting decoction filters, and Herba Equiseti Hiemalis decocts with water once, filters.Radix Bupleuri adds warm macerating secondary after water boil, each 3 hours, filters.Merge above each liquid and be condensed into cream.Fresh sheep liver infusion process is extracted secondary, uses for the first time ethanol (adding hydrochloric acid by solvent 0.05%) to extract, and uses for the second time 60% ethanol extraction, eight tastes, 60% ethanol percolate extraction such as all the other Rhizoma Picrorhizae, merge above ethanol extract, reclaim ethanol, be condensed into cream.Water, alcohol condensed cream are merged and add Concha Haliotidis powder and adjuvant, mix, obtain dry thing A.
8. the Chinese medicine composition of a kind of inflammation-dimishing and eye brightening pain relieving according to claim 1 according to claim 7, is characterized in that: take 80 parts of Concha Haliotidis, 64 parts of puncture multitudes, 40 parts of Radix Gentianae, 40 parts of Fructus Leonuris, 320 parts of fresh sheep livers, 80 parts of Radix Bupleuri, 40 parts of Rhizoma Coptidis, 80 parts of Rhizoma Picrorhizae, 80 parts of Radix Scutellariaes, 40 parts of Cortex Phellodendris, 80 parts of Semen Cassiaes, 80 parts of Faeces Vespertilioniss, 40 parts, Pericarpium Citri Reticulatae Viride, 40 parts of Flos Buddlejaes, 40 parts of Herba Equiseties Hiemalis.Concha Haliotidis is ground into fine powder, sieves, and Fructus Tribuli, Radix Gentianae, Fructus Leonuri decoct with water secondary, adds for the first time 10 times of water, decocts 2 hours, adds for the second time 8 times of water, decocts 1 hour, and collecting decoction, filters; Herba Equiseti Hiemalis adds 10 times of water, decocts 2 hours, filters; Radix Bupleuri adds warm macerating secondary after water boil, adds for the first time 10 times of water, adds for the second time 8 times of water, and each warm macerating 3 hours, filters; Merge above each liquid and be concentrated into relative density 1.20-1.30 (55 ℃); Fresh sheep liver infusion process is extracted secondary, use for the first time 3.5 times of 95% ethanol (adding hydrochloric acid by solvent 0.05%) to extract, use for the second time 2.5 times of 60% ethanol extraction, 7 times of 60% ethanol percolate extraction for eight tastes such as all the other Rhizoma Picrorhizae, merge above ethanol extract, reclaim ethanol, be concentrated into relative density 1.20-1.30 (55 ℃): water, alcohol condensed cream are merged to adjuvants such as adding Concha Haliotidis powder and starch, dextrin, obtain dry thing A.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105311568A (en) * | 2015-11-19 | 2016-02-10 | 郝艳 | Traditional Chinese medicinal liquor for relieving swelling |
| CN105311521A (en) * | 2015-11-19 | 2016-02-10 | 郝艳 | Traditional Chinese medicine with efficacies of diminishing inflammation and relieving pain |
| CN115337352A (en) * | 2022-08-23 | 2022-11-15 | 张传福 | Traditional Chinese medicine composition for eye patch and preparation method thereof |
-
2012
- 2012-11-02 CN CN201210430549.5A patent/CN103784579A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105311568A (en) * | 2015-11-19 | 2016-02-10 | 郝艳 | Traditional Chinese medicinal liquor for relieving swelling |
| CN105311521A (en) * | 2015-11-19 | 2016-02-10 | 郝艳 | Traditional Chinese medicine with efficacies of diminishing inflammation and relieving pain |
| CN115337352A (en) * | 2022-08-23 | 2022-11-15 | 张传福 | Traditional Chinese medicine composition for eye patch and preparation method thereof |
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Addressee: Longshunrong Pharmaceutical Factory, Tianjin, Zhongxin, Pharmaceutical Group Co. Document name: Notification of before Expiration of Request of Examination as to Substance |
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Application publication date: 20140514 |