CN105878710A - Traditional Chinese medicine composition for nourishing yin and blood, tranquilizing and tonifying heart and preparation method thereof - Google Patents
Traditional Chinese medicine composition for nourishing yin and blood, tranquilizing and tonifying heart and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composition for nourishing yin and blood, tranquilizing and tonifying heart and a preparation method thereof, and belongs to the field of traditional Chinese medicine modernization. The active ingredient of the composition is prepared from the following raw materials in parts by weight: 200 parts of radices rehmanniae, 50 parts of radix ophiopogonis, 25 parts of poria cocos, 25 parts of radix scrophulariae, 50 parts of asparagus cochinchinensis, 25 parts of codonopsis pilosula, 50 parts of schisandra chinensis, 50 parts of angelica sinensis, 25 parts of polygala tenuifolia (processed), 25 parts of platycodon grandiflorum, 50 parts of spina date seeds (fried), 50 parts of semen boitae, 25 parts of salvia miltiorrhiza, 25 parts of rhizoma acori graminei and 10 parts of cinnabar. The traditional Chinese medicine composition has the characteristic that a reasonable and stable active ingredient preparation method is obtained according to the study result on physicochemical property and pharmacologic action of ingredients of the medicinal materials. By adopting the technical scheme, the prepared medicine has stable and controllable quality, the curative effect is remarkably improved in comparison with preparations sold on the market, and the patient taking dosage is reduced. The traditional Chinese medicine has remarkable economic and social benefits.
Description
Technical field
The present invention relates to a kind of yin and blood nourishing calm the nerves the Chinese medicine composition and preparation method thereof of reinforcing the heart, in belonging to
Medicine modernization field.
Background technology
Reinforcing the heart sheet nourishing YIN and benefiting blood, heart tonifying and tranquilizing.For cardiopalmus Mental fatigue, the insomnia forgetfulness of deficiency of YIN insufficiency of blood,
Constipation with dry stool, aphtha of the mouth and tongue, the few tongue of red tongue, thready and rapid pulse.It is clinically used for the chronic disease of insomnia forgetfulness
Disease patient.
When running into the disease of the mind uneasinesses such as nervous cardiopalmus, insomnia forgetfulness, doctor trained in Western medicine is many with tranquilizer
Treat with sleeping pill etc.；But the untoward reaction of these medicines is the biggest, and may produce
Dependence effect.And the traditional Chinese medical science thinks that the pathogenic factor of insomnia is a lot, but nothing more than deficiency and excess two kinds.Wherein
Deficiency syndrome many genus deficiency of YIN-blood, the moon declines the excess of YANG and has difficulty in going to sleep.Prescription be often also adopted by effect substantially and
The medicine that untoward reaction is less.Reinforcing the heart sheet is exactly to treat the Chinese patent medicine that cardiopalmus is had palpitation, insomnia is slept less.
Mainly form with the medicine of nourishing YIN and benefiting blood, it is adaptable to insomnia and dreamful sleep, dysphoria, severe palpitation,
The treatment of the diseases such as hypomnesis.Treatment the deficiency of YIN and uneasy method.Disease sees palpitation and being susceptible to fright,
Forgetful insomnia, absentminded, many nocturnal emissions, aphtha of the mouth and tongue, constipation due to dry stool, the few tongue of red tongue, arteries and veins
Count accurately.
The prescription of reinforcing the heart sheet and preparation method be: Radix Rehmanniae 200g, 50g Radix Ophiopogonis, Poria 25g, Radix Scrophulariae
25g, Radix Asparagi 50g, Radix Codonopsis 25g, Fructus Schisandrae Chinensis 50g, Radix Angelicae Sinensis 50g, Radix Polygalae (system) 25g, Fructus Citri tangerinae
Stalk 25g, Semen Ziziphi Spinosae (stir-fry) 50g, Semen Platycladi 50g, Radix Salviae Miltiorrhizae 25g, Radix Glycyrrhizae (processed with honey) 25g, stone
Rhizoma Acori Graminei 25g, Cinnabaris 10g.Above ten Six-elements, Cinnabaris water flies or is ground into impalpable powder；Poria,
Radix Platycodonis, Radix Glycyrrhizae powder are broken into fine powder, sieve；Radix Rehmanniae, Radix Codonopsis, Radix Asparagi, boiling Radix Ophiopogonis secondary,
2 hours for the first time, 1.5 hours for the second time, collecting decoction, filter, filtrate is concentrated into paste；
Eight tastes such as remaining Semen Platycladi, are ground into coarse powder, (attached with the percolation under extractum item according to fluid extract
Record page 17), use 60% ethanol as solvent, after impregnating 24 hours, carry out percolation, collect liquid of filtering,
Reclaim ethanol, and be concentrated into paste；Take above-mentioned fine powder to mix with thick paste, make granule, be dried,
Tabletted, sugar coating, to obtain final product.
Summary of the invention
First technical problem that the invention solves the problems that is to provide a kind of yin and blood nourishing and calms the nerves the Chinese medicine of reinforcing the heart
Compositions.
Another technical problem that the invention solves the problems that is to provide the preparation method of above-mentioned Chinese medicine composition.
For achieving the above object, the present invention is by the following technical solutions；
A kind of yin and blood nourishing is calmed the nerves the Chinese medicine composition of reinforcing the heart, and its active component is former by following parts by weight
Material is made: Radix Rehmanniae 200 parts, Radix Ophiopogonis 50 parts, 25 parts of Poria, Radix Scrophulariae 25 parts, Radix Asparagi 50 parts,
Radix Codonopsis 25 parts, Fructus Schisandrae Chinensis 50 parts, Radix Angelicae Sinensis 50 parts, Radix Polygalae (system) 25 parts, Radix Platycodonis 25 parts, Ziziphi Spinosae
Core (stir-fry) 50 parts, Semen Platycladi 50 parts, Radix Salviae Miltiorrhizae 25 parts, Rhizoma Acori Graminei 25 parts, 10 parts of Cinnabaris.
Described active component uses following method to prepare:
1, each raw material is weighed by proportioning raw materials；；Poria, balloonflower powder are broken into fine powder, sieve；Radix Rehmanniae,
Radix Codonopsis, Radix Asparagi, boiling Radix Ophiopogonis secondary, 2 hours for the first time, 1.5 hours for the second time, merge and decoct
Liquid, filters, and filtrate is concentrated into paste；Eight tastes such as remaining Semen Platycladi, are ground into coarse powder, use 60% second
Solvent made by alcohol, carries out percolation after impregnating 24 hours, collects liquid of filtering, and reclaims ethanol, and is concentrated into thick paste
Shape；Take above-mentioned fine powder to mix with thick paste, make granule, be dried, obtain dried object A.
2, each raw material is weighed by proportioning raw materials；Cinnabaris water flies or is ground into impalpable powder；Poria, balloonflower powder
It is broken into fine powder, sieves；Radix Rehmanniae, Radix Codonopsis, Radix Asparagi, boiling Radix Ophiopogonis secondary, for the first time with 10 times
Amount soak by water 2 hours, second time 8 times amount soak by water 1.5 hours, collecting decoction, filtration, filtrate
It is concentrated into the thick paste of relative density 1.20-1.30 (55 DEG C)；Eight tastes such as remaining Semen Platycladi, are ground into coarse powder,
It is 60% ethanol as solvent with the concentration of volume percent of 8 times amount, after impregnating 24 hours, carries out percolation,
Collection is filtered liquid, reclaims ethanol, and is concentrated into the thick paste of relative density 1.20-1.30 (55 DEG C)；Take above-mentioned
Fine powder mixes with thick paste, makes granule, is dried, obtains dried object A.
Described pharmaceutical composition is possibly together with the acceptable adjuvant of pharmaceutics.
The acceptable adjuvant of described pharmaceutics is selected from starch, microcrystalline Cellulose, sucrose, aspartame, paste
Essence, lactose, Icing Sugar, glucose, sodium chloride, Carboxymethyl cellulose sodium, crospolyvinylpyrrolidone,
Any one in magnesium stearate, micropowder silica gel, vitamin C, cysteine, citric acid and sodium sulfite
Plant or several.
The dosage form of described Chinese medicine composition is peroral dosage form, include but not limited to pill, tablet, capsule or
Oral liquid.The selection of dosage form and the consumption of adjuvant belong to prior art.
A kind of yin and blood nourishing is calmed the nerves the preparation method of Chinese medicine composition of reinforcing the heart:
Weigh Radix Rehmanniae 200 parts, Radix Ophiopogonis 50 parts, 25 parts of Poria, Radix Scrophulariae 25 parts, Radix Asparagi 50 parts,
Radix Codonopsis 25 parts, Fructus Schisandrae Chinensis 50 parts, Radix Angelicae Sinensis 50 parts, Radix Polygalae (system) 25 parts, Radix Platycodonis 25 parts, Ziziphi Spinosae
Core (stir-fry) 50 parts, Semen Platycladi 50 parts, Radix Salviae Miltiorrhizae 25 parts, Rhizoma Acori Graminei 25 parts, 10 parts of Cinnabaris.Cinnabaris
Water flies or is ground into impalpable powder；Poria, balloonflower powder are broken into fine powder, sieve；Radix Rehmanniae, Radix Codonopsis, Radix Asparagi,
Boiling Radix Ophiopogonis secondary, 2 hours for the first time, 1.5 hours for the second time, collecting decoction, filter, filter
Liquid is concentrated into paste；Eight tastes such as remaining Semen Platycladi, are ground into coarse powder, use 60% ethanol as solvent, leaching
Stain carries out percolation after 24 hours, collect liquid of filtering, and reclaims ethanol, and is concentrated into paste；Take above-mentioned carefully
Powder mixes with thick paste, makes granule, is dried, obtains dried object A.
Preferably preparation method is: weigh each raw material by proportioning raw materials；Cinnabaris water flies or is ground into impalpable powder；
Poria, balloonflower powder are broken into fine powder, sieve；Radix Rehmanniae, Radix Codonopsis, Radix Asparagi, boiling Radix Ophiopogonis secondary, the
Once with 10 times amount soak by water 2 hours, second time 8 times amount soak by water 1.5 hours, collecting decoction,
Filtering, filtrate is concentrated into the thick paste of relative density 1.20-1.30 (55 DEG C)；Eight tastes such as remaining Semen Platycladi,
It is ground into coarse powder, is 60% ethanol as solvent with the concentration of volume percent of 8 times amount, impregnate 24 hours
After carry out percolation, collect liquid of filtering, reclaim ethanol, and be concentrated into relative density 1.20-1.30 (55 DEG C)
Thick paste；Take above-mentioned fine powder to mix with thick paste, make granule, be dried, obtain dried object A.
A kind of yin and blood nourishing is calmed the nerves the preparation of Chinese medicine composition of reinforcing the heart, and said preparation becomes with above-mentioned pharmaceutically active
Divide and add the acceptable adjuvant of pharmaceutics, make the acceptable dosage form of pharmaceutics.The present invention is utilized to obtain
When the active component of Chinese medicine composition prepares the various dosage form of required medicine, can be according to art of pharmacy
Prepared by conventional production process.As this active component is mixed with one or more carriers, then make corresponding
Dosage form.
The invention have the advantage that the present invention uses theory of Chinese medical science to analyze prescription composition, contained by each flavour of a drug
The physicochemical property of composition and pharmacological action, research has obtained the preparation method of reasonable, stable active component.
Use technical scheme, on duty go out stable and controllable for quality, curative effect compared with the existing commercial dosage forms
Significantly improve, patient's taking dose reduce pharmaceutical preparation, there is significant economic and social benefit.
Describe technical solution of the present invention by the following examples in detail, do not limit the enforcement of the present invention with this
Scope.
Detailed description of the invention
Embodiment 1: prepare Chinese medicine extract
One, prescription: Radix Rehmanniae 200g, 50g Radix Ophiopogonis, Poria 25g, Radix Scrophulariae 25g, Radix Asparagi 50g,
Radix Codonopsis 25g, Fructus Schisandrae Chinensis 50g, Radix Angelicae Sinensis 50g, Radix Polygalae (system) 25g, Radix Platycodonis 25g, Semen Ziziphi Spinosae (stir-fry) 50g,
Semen Platycladi 50g, Radix Salviae Miltiorrhizae 25g, Rhizoma Acori Graminei 25g, Cinnabaris 10g.
Two, preparation method:
Cinnabaris water flies or is ground into impalpable powder；Poria, balloonflower powder are broken into fine powder, sieve；Radix Rehmanniae, Radix Codonopsis,
Radix Asparagi, boiling Radix Ophiopogonis secondary, for the first time with 10 times amount soak by water 2 hours, for the second time with 8 times
Amount soak by water 1.5 hours, collecting decoction, filter, filtrate is concentrated into relative density 1.20-1.30 (55 DEG C)
Thick paste；Eight tastes such as remaining Semen Platycladi, are ground into coarse powder, are 60% with the concentration of volume percent of 8 times amount
Ethanol as solvent, carries out percolation after impregnating 24 hours, collect liquid of filtering, and reclaims ethanol, and is concentrated into phase
Thick paste to density 1.20-1.30 (55 DEG C)；Take above-mentioned fine powder to mix with thick paste, make granule, be dried,
Obtain dried object A and amount to 267g.
Embodiment 2: prepare Chinese medicine extract
One, prescription: Radix Rehmanniae 130kg, 32.5kg Radix Ophiopogonis, Poria 16.25kg, Radix Scrophulariae 16.25kg,
Radix Asparagi 32.5kg, Radix Codonopsis 16.25kg, Fructus Schisandrae Chinensis 32.5kg, Radix Angelicae Sinensis 32.5kg, Radix Polygalae (system) 16.25kg,
Radix Platycodonis 16.25kg, Semen Ziziphi Spinosae (stir-fry) 32.5kg, Semen Platycladi 32.5kg, Radix Salviae Miltiorrhizae 16.25g, Rhizoma Acori Graminei
16.25kg, Cinnabaris 6.5kg.
Two, preparation method:
Cinnabaris water flies or is ground into impalpable powder；Poria, balloonflower powder are broken into fine powder, sieve；Radix Rehmanniae, Radix Codonopsis,
Radix Asparagi, boiling Radix Ophiopogonis secondary, for the first time with 10 times amount soak by water 2 hours, for the second time with 8 times
Amount soak by water 1.5 hours, collecting decoction, filter, filtrate is concentrated into relative density 1.20-1.30 (55 DEG C)
Thick paste；Eight tastes such as remaining Semen Platycladi, are ground into coarse powder, are 60% with the concentration of volume percent of 8 times amount
Ethanol as solvent, carries out percolation after impregnating 24 hours, collect liquid of filtering, and reclaims ethanol, and is concentrated into phase
Thick paste to density 1.20-1.30 (55 DEG C)；Take above-mentioned fine powder to mix with thick paste, make granule, be dried,
Obtain dried object A and amount to 173.6kg.
Embodiment 3: prepare tablet
The active component 100g that embodiment 1 obtains, adds microcrystalline Cellulose 40g, cross-linked pvp 7g, tabletting,
Obtain tablet, every tablet weight 0.35g.
Embodiment 4: prepare capsule
The active component 1000g that embodiment 1 obtains, adds starch 250g, encapsulating capsule, obtains capsule, often
Grain weight 0.50g.
Embodiment 5: zoopery
One, materials and methods:
ANSHEN BUXIN WAN (lot number 100807), Pingshan, Foochow pharmaceutical factory provides.
Sedative jujube kernel capsule (lot number 110427), the Chongqing pharmaceutical factory of traditional Chinese medicine provides.
Reinforcing the heart sheet (lot number 110816), Longshunrong Pharmaceutical Factory, Tianjin Zhongxin Pharmaceutical Group Co., Ltd
Product.
Animal: ICR mice, 18-22g, is provided by Beijing Vital River Experimental Animals Technology Co., Ltd.,
Credit number: SCXK (capital) 2002-2003.
Take healthy ICR mice 60, random point 6 groups, often organize 10.Test sets: matched group (is given
Normal saline 20ml/kg)；Extract high and low dose group, reinforcing the heart sheet high and low dose group；Positive right
According to group sedative jujube kernel capsule 0.4g/kg.All it is made into 20ml suspension, by body weight with normal saline
0.2ml/10g is to mice ig.After being administered 50 minutes, mice puts the mice that the multiplex instrument of pharmacology physiology connects
In activity inventory box, after adapting to 3 minutes, start mice activity number of times in record 5 pulmonary abscess.
Two, the results are shown in Table 1.
Table 1
| Group | Dosage (g/kg) | 5 minutes movable number of times |
| Matched group | 105.3±39.5 | |
| Extract high dose group | 7.2 | 48.7±21.7*** |
| Extract low dose group | 1.8 | 88.3±31.8 |
| Reinforcing the heart sheet | 7.2 | 62.2±24.3** |
| Reinforcing the heart sheet | 1.8 | 91.0±23.4 |
| Sedative jujube kernel capsule group | 0.4 | 60.1±16.9** |
T checks: * * p ＜ 0.01, * * * p ＜ 0.001 compared with matched group, and extract and tablet height agent are described
Amount and sedative jujube kernel capsule all have sedation, and sedation is better than reinforcing the heart sheet.
Claims (8)
1. yin and blood nourishing is calmed the nerves a Chinese medicine composition for reinforcing the heart, and its active component is by following heavy
The raw material of amount number is made: Radix Rehmanniae 200 parts, Radix Ophiopogonis 50 parts, 25 parts of Poria, Radix Scrophulariae 25
Part, Radix Asparagi 50 parts, Radix Codonopsis 25 parts, Fructus Schisandrae Chinensis 50 parts, Radix Angelicae Sinensis 50 parts, Radix Polygalae (system)
25 parts, Radix Platycodonis 25 parts, Semen Ziziphi Spinosae (stir-fry) 50 parts, Semen Platycladi 50 parts, Radix Salviae Miltiorrhizae 25 parts,
Rhizoma Acori Graminei 25 parts, 10 parts of Cinnabaris.
A kind of yin and blood nourishing for the treatment of the most according to claim 1 is calmed the nerves the Chinese drug-treated group of reinforcing the heart
Compound, it is characterised in that described active component use following method prepare: Cinnabaris water fly or
It is ground into impalpable powder；Poria, balloonflower powder are broken into fine powder, sieve；Radix Rehmanniae, Radix Codonopsis, Radix Asparagi,
Boiling Radix Ophiopogonis secondary, 2 hours for the first time, 1.5 hours for the second time, collecting decoction, filter
Crossing, filtrate is concentrated into paste；Eight tastes such as remaining Semen Platycladi, are ground into coarse powder, with 60%
Ethanol as solvent, carries out percolation after impregnating 24 hours, collect liquid of filtering, and reclaims ethanol, and dense
It is reduced to paste；Take above-mentioned fine powder to mix with thick paste, make granule, be dried, obtain dried object
A。
A kind of yin and blood nourishing for the treatment of the most according to claim 2 is calmed the nerves the Chinese drug-treated group of reinforcing the heart
Compound, it is characterised in that: Cinnabaris water flies or is ground into impalpable powder；Poria, balloonflower powder are broken into carefully
Powder, sieves；Radix Rehmanniae, Radix Codonopsis, Radix Asparagi, boiling Radix Ophiopogonis secondary, for the first time with 10 times
Amount soak by water 2 hours, second time 8 times amount soak by water 1.5 hours, collecting decoction, filtration,
Filtrate is concentrated into the thick paste of relative density 1.20-1.30 (55 DEG C)；Eight tastes such as remaining Semen Platycladi,
It is ground into coarse powder, is 60% ethanol as solvent with the concentration of volume percent of 8 times amount, dipping
Carry out percolation after 24 hours, collect liquid of filtering, reclaim ethanol, and be concentrated into relative density 1.20-1.30
The thick paste of (55 DEG C)；Take above-mentioned fine powder to mix with thick paste, make granule, be dried, done
Dry thing A.
4. treat yin and blood nourishing peace according to the one in any of the one of claims 1 to 3
The Chinese medicine composition of god's reinforcing the heart, it is characterised in that: affiliated medicine is acceptable possibly together with pharmaceutics
Adjuvant.
A kind of yin and blood nourishing for the treatment of the most according to claim 4 is calmed the nerves the Chinese drug-treated group of reinforcing the heart
Compound, it is characterised in that: the acceptable adjuvant of described pharmaceutics selected from starch, microcrystalline Cellulose,
Sucrose, aspartame, dextrin, lactose, Icing Sugar, glucose, sodium chloride, hydroxylmethyl cellulose
Element sodium, crospolyvinylpyrrolidone, magnesium stearate, micropowder silica gel, vitamin C, half Guang
Any one or a few in propylhomoserin, citric acid and sodium sulfite.
A kind of yin and blood nourishing for the treatment of the most according to claim 4 is calmed the nerves the Chinese drug-treated group of reinforcing the heart
Compound, it is characterised in that: the dosage form of described Chinese medicine composition is peroral dosage form, including pill,
Tablet, capsule or oral liquid.
7. treating yin and blood nourishing to calm the nerves the preparation method of Chinese medicine composition of reinforcing the heart, it is special
Levy and be: weigh Radix Rehmanniae 200 parts, Radix Ophiopogonis 50 parts, 25 parts of Poria, Radix Scrophulariae 25 parts,
Radix Asparagi 50 parts, Radix Codonopsis 25 parts, Fructus Schisandrae Chinensis 50 parts, Radix Angelicae Sinensis 50 parts, Radix Polygalae (system) 25
Part, Radix Platycodonis 25 parts, Semen Ziziphi Spinosae (stir-fry) 50 parts, Semen Platycladi 50 parts, Radix Salviae Miltiorrhizae 25 parts, stone
Rhizoma Acori Graminei 25 parts, 10 parts of Cinnabaris.Cinnabaris water flies or is ground into impalpable powder；Poria, balloonflower powder
It is broken into fine powder, sieves；Radix Rehmanniae, Radix Codonopsis, Radix Asparagi, boiling Radix Ophiopogonis secondary, for the first time 2
Hour, 1.5 hours for the second time, collecting decoction, filter, filtrate is concentrated into paste；Remaining
Semen Platycladi etc. eight taste, is ground into coarse powder, uses 60% ethanol as solvent, impregnate 24 hours laggard
Row percolation, collects liquid of filtering, and reclaims ethanol, and is concentrated into paste；Take above-mentioned fine powder and thick paste
Mixing, makes granule, is dried, obtains dried object A.
One according to claim 1 the most according to claim 7 treats nourishing
The Chinese medicine composition of cloudy blood and tranquilizing mind reinforcing the heart, it is characterised in that: weigh Radix Rehmanniae 200 parts, Radix Ophiopogonis 50
Part, 25 parts of Poria, Radix Scrophulariae 25 parts, Radix Asparagi 50 parts, Radix Codonopsis 25 parts, Fructus Schisandrae Chinensis 50
Part, Radix Angelicae Sinensis 50 parts, Radix Polygalae (system) 25 parts, Radix Platycodonis 25 parts, Semen Ziziphi Spinosae (stir-fry) 50 parts, cypress
Sub-core 50 parts, Radix Salviae Miltiorrhizae 25 parts, Rhizoma Acori Graminei 25 parts, 10 parts of Cinnabaris.Cinnabaris water flies or powder
It is broken into impalpable powder；Poria, balloonflower powder are broken into fine powder, sieve；Radix Rehmanniae, Radix Codonopsis, Radix Asparagi, wheat
Winter boiling secondary, for the first time with 10 times amount soak by water 2 hours, uses 8 times amount for the second time
Soak by water 1.5 hours, collecting decoction, filter, filtrate is concentrated into relative density 1.20-1.30
The thick paste of (55 DEG C)；Eight tastes such as remaining Semen Platycladi, are ground into coarse powder, with the volume of 8 times amount
Percent concentration is 60% ethanol as solvent, carries out percolation after impregnating 24 hours, collects liquid of filtering,
Reclaim ethanol, and be concentrated into the thick paste of relative density 1.20-1.30 (55 DEG C)；Take above-mentioned fine powder
Mix with thick paste, make granule, be dried, obtain dried object A.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109078148A (en) * | 2018-09-21 | 2018-12-25 | 武汉黄家医圈生物医药有限公司 | One seed ginseng Siberian cocklebur mind easing and its preparation process |
| CN110638912A (en) * | 2018-06-26 | 2020-01-03 | 李华杰 | Traditional Chinese medicine preparation for treating arrhythmia |
-
2014
- 2014-12-03 CN CN201410724328.8A patent/CN105878710A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110638912A (en) * | 2018-06-26 | 2020-01-03 | 李华杰 | Traditional Chinese medicine preparation for treating arrhythmia |
| CN109078148A (en) * | 2018-09-21 | 2018-12-25 | 武汉黄家医圈生物医药有限公司 | One seed ginseng Siberian cocklebur mind easing and its preparation process |
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Application publication date: 20160824 |