CN107961317A - A kind of medicine of reducing blood lipid and preparation method thereof - Google Patents

A kind of medicine of reducing blood lipid and preparation method thereof Download PDF

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Publication number
CN107961317A
CN107961317A CN201610914397.4A CN201610914397A CN107961317A CN 107961317 A CN107961317 A CN 107961317A CN 201610914397 A CN201610914397 A CN 201610914397A CN 107961317 A CN107961317 A CN 107961317A
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China
Prior art keywords
parts
medicine
reducing blood
blood lipid
medicinal extract
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Pending
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CN201610914397.4A
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Chinese (zh)
Inventor
陈修仕
陈才献
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GUIZHOU RUNSHENG PHARMACEUTICAL Co Ltd
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GUIZHOU RUNSHENG PHARMACEUTICAL Co Ltd
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Priority to CN201610914397.4A priority Critical patent/CN107961317A/en
Publication of CN107961317A publication Critical patent/CN107961317A/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/40—Cornaceae (Dogwood family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/481—Astragalus (milkvetch)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/482—Cassia, e.g. golden shower tree
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484—Glycyrrhiza (licorice)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/488—Pueraria (kudzu)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/80—Scrophulariaceae (Figwort family)
    • A61K36/804—Rehmannia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
    • A61K36/815—Lycium (desert-thorn)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8969—Polygonatum (Solomon's seal)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Botany (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

The invention discloses a kind of medicine of reducing blood lipid and preparation method thereof, the medicine is mainly made by Fructus Corni, radix polygonati officinalis, cassia seed, glutinous rehmannia, matrimony vine, pueraria lobata, radix glycyrrhizae, radix astragali and Mesona chinensis Benth.Each raw material has synergistic effect well in prescription, and play has the function that reduction blood fat altogether, available for treating hypertension；Evident in efficacy, treatment cycle is short, and safety is without side-effects.

Description

A kind of medicine of reducing blood lipid and preparation method thereof
Technical field
The present invention relates to a kind of medicine of reducing blood lipid and preparation method thereof, belong to the field of medicine technology.
Background technology
Present hypertension, hyperlipidemia have been a kind of common diseases occurred frequently, as the improvement of people's living standards, people Diet it is increasingly abundanter, the nutrition of people's intake is also increasingly abundanter, but the amount of exercise of opposite people is less and less, from And cause hypertension, hyperlipidemia it is occurred frequently.Harm of the hyperlipidemia to human body is very large, and is often accompanied by hypertension, Treatment can cause the malignant diseases such as cerebral apoplexy, coronary heart disease, cerebral infarction, kidney failure not in time, seriously affect the health of people.
For above-mentioned disease, although the medicine currently used for reducing blood lipid has very much, most drugs are just for medicine Effect is slow, treatment cycle length.
The content of the invention
It is an object of the present invention to provide a kind of medicine of reducing blood lipid and preparation method thereof.The medicine has reduction blood The effect of fat, available for treating hypertension；Evident in efficacy, treatment cycle is short, and safety is without side-effects.
In order to solve the above technical problems, the present invention is realized using following technical scheme：
A kind of medicine of reducing blood lipid, calculates by weight, mainly by 10-40 parts of Fructus Corni, 20-40 parts of radix polygonati officinalis, cassia seed 10-30 20-40 parts of part, 10-30 parts of glutinous rehmannia, 20-30 parts of matrimony vine, 10-30 parts of pueraria lobata, 20-40 parts of radix glycyrrhizae, 30-50 parts of radix astragali and Mesona chinensis Benth It is made.
The medicine of foregoing reducing blood lipid, calculates by weight, mainly by 15-35 parts of Fructus Corni, 25-35 parts of radix polygonati officinalis, Cassia 15-25 parts sub-, 15-25 parts of glutinous rehmannia, 23-27 parts of matrimony vine, 15-25 parts of pueraria lobata, 25-35 parts of radix glycyrrhizae, 35-45 parts of radix astragali and Mesona chinensis Benth 25-35 parts are made.
The medicine of foregoing reducing blood lipid, calculates by weight, mainly by 20 parts of Fructus Corni, 30 parts of radix polygonati officinalis, 20 parts of cassia seed, 30 parts of 20 parts of glutinous rehmannia, 25 parts of matrimony vine, 20 parts of pueraria lobata, 30 parts of radix glycyrrhizae, 40 parts of radix astragali and Mesona chinensis Benth are made.
A kind of production method of the medicine of foregoing reducing blood lipid, takes said medicine, can add auxiliary material, can also be not added with auxiliary Material, is made oral formulations.
The production method of the medicine of foregoing reducing blood lipid, the oral formulations for granule, capsule, tablet, pill, dissipate Agent or creme.
The production method of the medicine of foregoing reducing blood lipid, the granule so make：Said medicine is taken, adds 10 times of amount water Decoct 3 times, each 1.5h, filtering, merges decoction liquor, and relative density is the medicinal extract of 1.15-1.20 when being condensed into 50-60 DEG C, is soaked Cream and the starch and 20% dextrine powder mixing granulation of medicinal extract amount 20%, it is dry, to obtain the final product.
The production method of the medicine of foregoing reducing blood lipid, the production method of the capsule are：Said medicine is taken, with 6 times The alcohol reflux of amount 70% extracts 2 times, every time 1 it is small when, extracting solution filtering, filtrate recycling ethanol is simultaneously condensed into opposite at 50-60 DEG C Density is the medicinal extract of 1.20-1.25, and the starch and 0.7% magnesium stearate for separately taking medicinal extract amount 30% are mixed with medicinal extract, with 60% second Alcohol is pelletized, and dry, pulverize, and fills capsule, to obtain the final product.
The production method of the medicine of foregoing reducing blood lipid, the production method of the tablet are：Said medicine is taken, adds 10 times of amounts Water decocts 3 times, each 1.5h, and filtering, merges decoction liquor, and relative density is the medicinal extract of 1.15-1.20 when being condensed into 50-60 DEG C, Medicinal extract is mixed with above-mentioned mixed powder and the starch of medicinal extract amount 20%, tabletting, film coating, to obtain the final product.
Compared with prior art, medicine of the present invention mainly by Fructus Corni, radix polygonati officinalis, cassia seed, glutinous rehmannia, matrimony vine, pueraria lobata, Radix glycyrrhizae, radix astragali and Mesona chinensis Benth are made.Each raw material has synergistic effect well in prescription, plays altogether with the work for reducing blood fat With available for treating hypertension；Evident in efficacy, treatment cycle is short, and safety is without side-effects.
Embodiment：
Embodiment 1.
Formula：Fructus Corni 20kg, radix polygonati officinalis 30kg, cassia seed 20kg, glutinous rehmannia 20kg, matrimony vine 25kg, pueraria lobata 20kg, radix glycyrrhizae 30kg, Radix astragali 40kg and Mesona chinensis Benth 30kg.
Technique：Said medicine is taken, adds 10 times of amount water to decoct 3 times, each 1.5h, filtering, merges decoction liquor, be condensed into 50- Relative density is the medicinal extract of 1.15-1.20, medicinal extract and the starch and 20% dextrine powder mixing granulation of medicinal extract amount 20% at 60 DEG C, is done It is dry, up to granule.
Specification：5g/ bags.
Usage and dosage：Each 5-10g, it is 2-3 times daily.

Claims (8)

  1. A kind of 1. medicine of reducing blood lipid, it is characterised in that：Calculate by weight, mainly by 10-40 parts of Fructus Corni, radix polygonati officinalis 20-40 Part, 10-30 parts of cassia seed, 10-30 parts of glutinous rehmannia, 20-30 parts of matrimony vine, 10-30 parts of pueraria lobata, 20-40 parts of radix glycyrrhizae, 30-50 parts of radix astragali It is made for 20-40 parts with Mesona chinensis Benth.
  2. 2. the medicine of reducing blood lipid as claimed in claim 1, it is characterised in that：Calculate by weight, mainly by Fructus Corni 15-35 Part, 25-35 parts of radix polygonati officinalis, 15-25 parts of cassia seed, 15-25 parts of glutinous rehmannia, 23-27 parts of matrimony vine, 15-25 parts of pueraria lobata, 25-35 parts of radix glycyrrhizae, 25-35 parts of 35-45 parts of radix astragali and Mesona chinensis Benth are made.
  3. 3. the medicine of reducing blood lipid as claimed in claim 2, it is characterised in that：Calculate by weight, mainly by 20 parts of Fructus Corni, 30 parts of 30 parts of radix polygonati officinalis, 20 parts of cassia seed, 20 parts of glutinous rehmannia, 25 parts of matrimony vine, 20 parts of pueraria lobata, 30 parts of radix glycyrrhizae, 40 parts of radix astragali and Mesona chinensis Benth It is made.
  4. A kind of 4. production method of the medicine of reducing blood lipid as any one of claim 1-3, it is characterised in that：Take above-mentioned Medicine, can add auxiliary material, can also be not added with auxiliary material, oral formulations are made.
  5. 5. the production method of the medicine of reducing blood lipid as claimed in claim 4, it is characterised in that：The oral formulations are particle Agent, capsule, tablet, pill, powder or creme.
  6. 6. the production method of the medicine of reducing blood lipid as claimed in claim 5, it is characterised in that：The granule so makes： Said medicine is taken, adds 10 times of amount water to decoct 3 times, each 1.5h, filtering, merges decoction liquor, relative density when being condensed into 50-60 DEG C For the medicinal extract of 1.15-1.20, medicinal extract and the starch and 20% dextrine powder mixing granulation of medicinal extract amount 20% are dry, to obtain the final product.
  7. 7. the production method of the medicine of reducing blood lipid as claimed in claim 5, it is characterised in that：The production method of the capsule For：Take said medicine, with 6 times amount 70% alcohol reflux extract 2 times, every time 1 it is small when, extracting solution filtering, filtrate recycling ethanol is simultaneously Relative density is the medicinal extract of 1.20-1.25 when being condensed into 50-60 DEG C, separately takes the starch of medicinal extract amount 30% and 0.7% magnesium stearate Mix with medicinal extract, with 60% alcohol granulation, dry, pulverize, fill capsule, to obtain the final product.
  8. 8. the production method of the medicine of reducing blood lipid as claimed in claim 5, it is characterised in that：The production method of the tablet For：Said medicine is taken, adds 10 times of amount water to decoct 3 times, each 1.5h, filtering, merges decoction liquor, be condensed into opposite at 50-60 DEG C Density is the medicinal extract of 1.15-1.20, and medicinal extract is mixed with above-mentioned mixed powder and the starch of medicinal extract amount 20%, tabletting, film coating, i.e., .
CN201610914397.4A 2016-10-20 2016-10-20 A kind of medicine of reducing blood lipid and preparation method thereof Pending CN107961317A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201610914397.4A CN107961317A (en) 2016-10-20 2016-10-20 A kind of medicine of reducing blood lipid and preparation method thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201610914397.4A CN107961317A (en) 2016-10-20 2016-10-20 A kind of medicine of reducing blood lipid and preparation method thereof

Publications (1)

Publication Number Publication Date
CN107961317A true CN107961317A (en) 2018-04-27

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ID=61997192

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201610914397.4A Pending CN107961317A (en) 2016-10-20 2016-10-20 A kind of medicine of reducing blood lipid and preparation method thereof

Country Status (1)

Country Link
CN (1) CN107961317A (en)

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Application publication date: 20180427