CN107970359A - A kind of medicine for treating diarrhea and preparation method thereof - Google Patents
A kind of medicine for treating diarrhea and preparation method thereof Download PDFInfo
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- CN107970359A CN107970359A CN201610918826.5A CN201610918826A CN107970359A CN 107970359 A CN107970359 A CN 107970359A CN 201610918826 A CN201610918826 A CN 201610918826A CN 107970359 A CN107970359 A CN 107970359A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
- A61K36/815—Lycium (desert-thorn)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8968—Ophiopogon (Lilyturf)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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Abstract
The invention discloses a kind of medicine for treating diarrhea and preparation method thereof, the medicine is mainly made by catechu, japanese white birch bark, radish seed, centella, Turczaninowia fastigiata, ophiopogon, the fruit of Chinese wolfberry, radix glycyrrhizae and Mesona chinensis Benth.Each raw material has synergistic effect well in prescription, and manufactured medicine can be used for treating diarrhea;Evident in efficacy, treatment cycle is short, and safety is without side-effects.
Description
Technical field
The present invention relates to a kind of medicine for treating diarrhea and preparation method thereof, belong to the field of medicine technology.
Background technology
Diarrhea (diarrhea) is clinically common symptom, can be caused because of a variety of diseases.The daily defecation 1 of normal person
It is secondary, discharge amount about 200~400g of excrement.Though also there is a few peoples' defecation 2~3 times daily, fecal character is normal, then cannot claim
For diarrhea.Diarrhea generally refers to daily times of defecation increase or defecation frequency is frequent, and excrement is thin or containing mucus purulence blood, or
Also contain indigestible food and other pathologic contents.Diarrhea is generally divided into acute diarrhea and two class of chronic diarrhea, it is preceding
Person refers to that diarrhea is in acute onset, lasts of short duration, and the latter generally refers to more than 2 months persons of diarrhea.
For above-mentioned disease, although currently used for treat diarrhea medicine have very much, most drugs just for
Drug effect is slow, treatment cycle length.
The content of the invention
It is an object of the present invention to provide a kind of medicine for treating diarrhea and preparation method thereof.The medicine can be used for treating
Diarrhea;Evident in efficacy, treatment cycle is short, and safety is without side-effects.
In order to solve the above technical problems, the present invention is realized using following technical scheme:A kind of medicine for treating diarrhea, by weight
Measure part to calculate, mainly by 1-20 parts of catechu, 1-20 parts of japanese white birch bark, 10-30 parts of radish seed, 20-40 parts of centella, Turczaninowia fastigiata 1-20
20-40 parts of part, ophiopogon 10-30 part, 1-20 parts of the fruit of Chinese wolfberry, 20-40 parts of radix glycyrrhizae and Mesona chinensis Benth are made.
The medicine of foregoing treatment diarrhea, calculates by weight, mainly by 5-15 parts of catechu, 5-15 parts of japanese white birch bark, radish
15-25 parts sub-, 25-35 parts of accumulated snow, 5-15 parts of Turczaninowia fastigiata, ophiopogon 15-25 part, 5-15 parts of the fruit of Chinese wolfberry, 25-35 parts of radix glycyrrhizae and Mesona chinensis Benth
25-35 parts are made.
The medicine of foregoing treatment diarrhea, calculates by weight, mainly by 10 parts of catechu, 10 parts of japanese white birch bark, radish seed 20
30 parts of part, 30 parts of accumulated snow, 10 parts of Turczaninowia fastigiata, 20 parts of ophiopogon, 10 parts of the fruit of Chinese wolfberry, 30 parts of radix glycyrrhizae and Mesona chinensis Benth are made.
A kind of production method of the medicine of foregoing treatment diarrhea, takes said medicine, can add auxiliary material, can also be not added with auxiliary
Material, is made oral formulations.
The production method of the medicine of foregoing treatment diarrhea, the oral formulations for granule, capsule, tablet, pill,
Powder or creme.
The production method of the medicine of foregoing treatment diarrhea, the granule so make:Said medicine is taken, adds 10 times of amounts
Water decocts 3 times, each 1.5h, and filtering, merges decoction liquor, and relative density is the medicinal extract of 1.15-1.20 when being condensed into 50-60 DEG C,
Medicinal extract and the starch and 20% dextrine powder mixing granulation of medicinal extract amount 20%, it is dry, to obtain the final product.
The production method of the medicine of foregoing treatment diarrhea, the production method of the capsule are:Said medicine is taken, with 6
The alcohol reflux of times amount 70% extracts 2 times, every time 1 it is small when, extracting solution filtering, filtrate recycling ethanol is simultaneously condensed into 50-60 DEG C of phase
To the medicinal extract that density is 1.20-1.25, the starch and 0.7% magnesium stearate for separately taking medicinal extract amount 30% are mixed with medicinal extract, with 60%
Alcohol granulation, dry, pulverize, and fill capsule, to obtain the final product.
The production method of the medicine of foregoing treatment diarrhea, the production method of the tablet are:Said medicine is taken, adds 10 times
Measure water to decoct 3 times, each 1.5h, filtering, merges decoction liquor, and relative density is the leaching of 1.15-1.20 when being condensed into 50-60 DEG C
Cream, medicinal extract are mixed with above-mentioned mixed powder and the starch of medicinal extract amount 20%, tabletting, film coating, to obtain the final product.
Compared with prior art, medicine of the present invention is mainly by catechu, japanese white birch bark, radish seed, centella, Turczaninowia fastigiata, wheat
Winter, the fruit of Chinese wolfberry, radix glycyrrhizae and Mesona chinensis Benth are made.Each raw material has in prescription acts synergistically well, and manufactured medicine can use
In treatment diarrhea;Evident in efficacy, treatment cycle is short, and safety is without side-effects.
Embodiment:
Embodiment 1.
Formula:Catechu 10kg, japanese white birch bark 10kg, radish seed 20kg, accumulated snow 30kg, Turczaninowia fastigiata 10kg, ophiopogon 20kg, the fruit of Chinese wolfberry
10kg, radix glycyrrhizae 30kg and Mesona chinensis Benth 30kg.
Technique:10 times of amount water are added to decoct 3 times, each 1.5h, filtering, merges decoction liquor, be condensed into relatively close at 50-60 DEG C
The medicinal extract for 1.15-1.20, medicinal extract and the starch and 20% dextrine powder mixing granulation of medicinal extract amount 20% are spent, it is dry, up to particle
Agent.
Specification:5g/ bags.
Usage and dosage:Each 5-10g, it is 2-3 times daily.
Embodiment 2.
Formula:Catechu 10kg, japanese white birch bark 10kg, radish seed 20kg, accumulated snow 30kg, Turczaninowia fastigiata 10kg, ophiopogon 20kg, the fruit of Chinese wolfberry
10kg, radix glycyrrhizae 30kg and Mesona chinensis Benth 30kg.
Technique:Take said medicine, with 6 times amount 70% alcohol reflux extract 2 times, every time 1 it is small when, extracting solution filtering, filtrate
The medicinal extract that relative density is 1.20-1.25 when recycling ethanol and being condensed into 50-60 DEG C, separately takes the starch and 0.7% of medicinal extract amount 30%
Magnesium stearate and medicinal extract mix, with 60% alcohol granulation, dry, pulverize, capsule filled, up to capsule.
Specification:0.3g/.
Usage and dosage:Each 5-10g, it is 2-3 times daily.
Embodiment 3.
Formula:Catechu 10kg, japanese white birch bark 10kg, radish seed 20kg, accumulated snow 30kg, Turczaninowia fastigiata 10kg, ophiopogon 20kg, the fruit of Chinese wolfberry
10kg, radix glycyrrhizae 30kg and Mesona chinensis Benth 30kg.
Technique:Said medicine is taken, adds 10 times of amount water to decoct 3 times, each 1.5h, filtering, merges decoction liquor, be condensed into 50-
Relative density is the medicinal extract of 1.15-1.20 at 60 DEG C, and medicinal extract is mixed with above-mentioned mixed powder and the starch of medicinal extract amount 20%, tabletting, bag
Film-coating, up to tablet.
Specification:0.3g/ pieces.
Usage and dosage:Each 5-10g, it is 2-3 times daily.
Claims (8)
- A kind of 1. medicine for treating diarrhea, it is characterised in that:Calculate by weight, mainly by 1-20 parts of catechu, japanese white birch bark 1-20 Part, 10-30 parts of radish seed, 20-40 parts of centella, 1-20 parts of Turczaninowia fastigiata, ophiopogon 10-30 part, 1-20 parts of the fruit of Chinese wolfberry, radix glycyrrhizae 20-40 20-40 parts of part and Mesona chinensis Benth are made.
- 2. the medicine for the treatment of diarrhea as claimed in claim 1, it is characterised in that:Calculate by weight, mainly by catechu 5-15 Part, 5-15 parts of japanese white birch bark, 15-25 parts of radish seed, 25-35 parts of accumulated snow, 5-15 parts of Turczaninowia fastigiata, ophiopogon 15-25 part, fruit of Chinese wolfberry 5-15 25-35 parts of part, 25-35 parts of radix glycyrrhizae and Mesona chinensis Benth are made.
- 3. the medicine for the treatment of diarrhea as claimed in claim 2, it is characterised in that:Calculate by weight, mainly by 10 parts of catechu, 10 parts of japanese white birch bark, 20 parts of radish seed, 30 parts of accumulated snow, 10 parts of Turczaninowia fastigiata, 20 parts of ophiopogon, 10 parts of the fruit of Chinese wolfberry, 30 parts of radix glycyrrhizae and Mesona chinensis Benth 30 parts are made.
- A kind of 4. production method of the medicine for the treatment of diarrhea as any one of claim 1-3, it is characterised in that:Take Medicine is stated, auxiliary material can be added, auxiliary material can also be not added with, oral formulations are made.
- 5. the production method of the medicine for the treatment of diarrhea as claimed in claim 4, it is characterised in that:The oral formulations are particle Agent, capsule, tablet, pill, powder or creme.
- 6. the production method of the medicine for the treatment of diarrhea as claimed in claim 5, it is characterised in that:The granule is so made Make:Said medicine is taken, adds 10 times of amount water to decoct 3 times, each 1.5h, filtering, merges decoction liquor, be condensed into opposite at 50-60 DEG C Density is the starch and 20% dextrine powder mixing granulation of the medicinal extract of 1.15-1.20, medicinal extract and medicinal extract amount 20%, dry, to obtain the final product.
- 7. the production method of the medicine for the treatment of diarrhea as claimed in claim 5, it is characterised in that:The making side of the capsule Method is:Take said medicine, with 6 times amount 70% alcohol reflux extract 2 times, every time 1 it is small when, extracting solution filtering, filtrate recycling ethanol And relative density is the medicinal extract of 1.20-1.25 when being condensed into 50-60 DEG C, separately takes the starch of medicinal extract amount 30% and 0.7% stearic acid Magnesium is mixed with medicinal extract, with 60% alcohol granulation, dry, pulverize, and fills capsule, to obtain the final product.
- 8. the production method of the medicine for the treatment of diarrhea as claimed in claim 5, it is characterised in that:The production method of the tablet For:Said medicine is taken, adds 10 times of amount water to decoct 3 times, each 1.5h, filtering, merges decoction liquor, be condensed into opposite at 50-60 DEG C Density is the medicinal extract of 1.15-1.20, and medicinal extract is mixed with above-mentioned mixed powder and the starch of medicinal extract amount 20%, tabletting, film coating, i.e., .
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CN201610918826.5A CN107970359A (en) | 2016-10-21 | 2016-10-21 | A kind of medicine for treating diarrhea and preparation method thereof |
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CN201610918826.5A CN107970359A (en) | 2016-10-21 | 2016-10-21 | A kind of medicine for treating diarrhea and preparation method thereof |
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CN107970359A true CN107970359A (en) | 2018-05-01 |
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
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WO2022202748A1 (en) * | 2021-03-23 | 2022-09-29 | 一丸ファルコス株式会社 | Powdery preparation and method for manufacturing same |
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2016
- 2016-10-21 CN CN201610918826.5A patent/CN107970359A/en active Pending
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2022202748A1 (en) * | 2021-03-23 | 2022-09-29 | 一丸ファルコス株式会社 | Powdery preparation and method for manufacturing same |
JP7160299B1 (en) * | 2021-03-23 | 2022-10-25 | 一丸ファルコス株式会社 | Powder formulation and its manufacturing method |
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Application publication date: 20180501 |