CN109512933A - A kind of drug and preparation method thereof for treating diarrhea - Google Patents

A kind of drug and preparation method thereof for treating diarrhea Download PDF

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Publication number
CN109512933A
CN109512933A CN201710847111.XA CN201710847111A CN109512933A CN 109512933 A CN109512933 A CN 109512933A CN 201710847111 A CN201710847111 A CN 201710847111A CN 109512933 A CN109512933 A CN 109512933A
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China
Prior art keywords
parts
drug
diarrhea
medicinal extract
treatment
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Pending
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CN201710847111.XA
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Chinese (zh)
Inventor
龙凤荣
李珂
王瑶
孙敏
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GUIZHOU HONGKANG PHARMACEUTICAL CO Ltd
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GUIZHOU HONGKANG PHARMACEUTICAL CO Ltd
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Priority to CN201710847111.XA priority Critical patent/CN109512933A/en
Publication of CN109512933A publication Critical patent/CN109512933A/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484—Glycyrrhiza (licorice)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/64—Orobanchaceae (Broom-rape family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
    • A61K36/815—Lycium (desert-thorn)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8968—Ophiopogon (Lilyturf)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Mycology (AREA)
  • Medical Informatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

The invention discloses a kind of drug and preparation method thereof for treating diarrhea, the drug is mainly made by Herba Cistanches, Fructus Fici Beecheyanae, tremella, folium panacis japonici cum caule, agaric, Radix Ophiopogonis, fructus lycii, Radix Glycyrrhizae and Mesona chinensis Benth.Each raw material has in prescription acts synergistically well, and manufactured drug can be used for treating diarrhea；Significant in efficacy, treatment cycle is short, and safety is without side-effects.

Description

A kind of drug and preparation method thereof for treating diarrhea
Technical field
The present invention relates to a kind of drugs and preparation method thereof for treating diarrhea, belong to the field of drug technology.
Technical background
Diarrhea (diarrhea) is clinically common symptom, can be caused because of a variety of diseases.The daily defecation 1 of normal person It is secondary, amount about 200~400g of excrement is discharged.Though also having a few peoples defecation 2~3 times daily, fecal character is normal, then cannot claim For diarrhea.Diarrhea generally refers to daily times of defecation increase or defecation frequency is frequent, and excrement is thin or contains mucus purulence blood, or Also contain indigestible food and other pathologic contents.Diarrhea is generally divided into acute diarrhea and two class of chronic diarrhea, it is preceding Person refers to diarrhea in acute onset, lasts of short duration, and it is more than 2 months persons that the latter, which generally refers to diarrhea,.
For above-mentioned disease, although currently used for treat diarrhea drug have very much, most drugs just for Drug effect is slow, and treatment cycle is long.
Summary of the invention:
The object of the present invention is to provide a kind of drugs and preparation method thereof for treating diarrhea.The medicine can be used for treating diarrhea； Significant in efficacy, treatment cycle is short, and safety is without side-effects.
In order to solve the above technical problems, the present invention is implemented with the following technical solutions: a kind of drug for treating diarrhea, by weight It measures part to calculate, mainly by 1-20 parts of Herba Cistanches, 1-20 parts of Fructus Fici Beecheyanae, 10-30 parts of tremella, 20-40 parts of folium panacis japonici cum caule, agaric 1-20 Part, Radix Ophiopogonis 10-30 part, 1-20 parts of fructus lycii, 20-40 parts of Radix Glycyrrhizae and 20-40 parts of Mesona chinensis Benth are made.
The drug for the treatment of diarrhea above-mentioned, calculates by weight, mainly by 5-15 parts of Herba Cistanches, 5-15 parts of Fructus Fici Beecheyanae, silver 15-25 parts of ear, 25-35 parts of accumulated snow, 5-15 parts of agaric, Radix Ophiopogonis 15-25 part, 5-15 parts of fructus lycii, 25-35 parts of Radix Glycyrrhizae and Mesona chinensis Benth 25-35 parts are made.
The drug for the treatment of diarrhea above-mentioned, calculates, by weight mainly by 10 parts of Herba Cistanches, 10 parts of Fructus Fici Beecheyanae, tremella 20 Part, 30 parts of accumulated snow, 10 parts of agaric, 20 parts of Radix Ophiopogonis, 10 parts of fructus lycii, 30 parts of Radix Glycyrrhizae and 30 parts of Mesona chinensis Benth are made.
A kind of production method of the drug for the treatment of diarrhea above-mentioned, takes said medicine, can add auxiliary material, can also be not added auxiliary Material, is made oral preparation.
It is above-mentioned treatment diarrhea drug production method, the oral preparation be granule, capsule, tablet, pill, Powder or creme.
The production method of the drug for the treatment of diarrhea above-mentioned, the granule make in this way: taking said medicine, add 10 times of amounts Water decocts 3 times, each 1.5h, and filtering merges decoction liquor, and relative density is the medicinal extract of 1.15-1.20 when being condensed into 50-60 DEG C, The starch of medicinal extract and medicinal extract amount 20% and 20% dextrine powder mixing granulation, it is dry to get.
The production method of the drug for the treatment of diarrhea above-mentioned, the production method of the capsule are as follows: said medicine is taken, with 6 The alcohol reflux of amount 70% extracts 2 times again, and 1 hour every time, extracting solution filtering, filtrate recycling ethanol was simultaneously condensed into 50-60 DEG C of phase The medicinal extract for being 1.20-1.25 to density separately takes the starch of medicinal extract amount 30% and 0.7% magnesium stearate and medicinal extract to mix, with 60% Alcohol granulation dry, pulverize, fill capsule to get.
The production method of the drug for the treatment of diarrhea above-mentioned, the production method of the tablet are as follows: take said medicine, add 10 times It measures water to decoct 3 times, each 1.5h, filtering merges decoction liquor, and relative density is the leaching of 1.15-1.20 when being condensed into 50-60 DEG C The starch of cream, medicinal extract and above-mentioned mixed powder and medicinal extract amount 20% mixes, tabletting, film coating to get.
Compared with prior art, drug of the present invention is mainly by Herba Cistanches, Fructus Fici Beecheyanae, tremella, folium panacis japonici cum caule, agaric, wheat Winter, fructus lycii, Radix Glycyrrhizae and Mesona chinensis Benth are made.Each raw material has synergistic effect well in prescription, and manufactured drug is available In treatment diarrhea；Significant in efficacy, treatment cycle is short, and safety is without side-effects.
Specific embodiment:
Embodiment 1.
Formula: Herba Cistanches 10kg, Fructus Fici Beecheyanae 10kg, tremella 20kg, accumulated snow 30kg, agaric 10kg, Radix Ophiopogonis 20kg, fructus lycii 10kg, Radix Glycyrrhizae 30kg and Mesona chinensis Benth 30kg.
Technique: adding 10 times of amount water to decoct 3 times, each 1.5h, and filtering merges decoction liquor, is condensed into relatively close at 50-60 DEG C Degree is the medicinal extract of 1.15-1.20, the starch of medicinal extract and medicinal extract amount 20% and 20% dextrine powder mixing granulation, it is dry to get particle Agent.
Specification: 5g/ bags.
Usage and dosage: each 5-10g, it is 2-3 times daily.
Embodiment 2.
Formula: Herba Cistanches 10kg, Fructus Fici Beecheyanae 10kg, tremella 20kg, accumulated snow 30kg, agaric 10kg, Radix Ophiopogonis 20kg, fructus lycii 10kg, Radix Glycyrrhizae 30kg and Mesona chinensis Benth 30kg.
Technique: taking said medicine, is extracted 2 times with the alcohol reflux of 6 times of amounts 70%, 1 hour every time, extracting solution filtered, filtrate The medicinal extract that relative density is 1.20-1.25 when recycling ethyl alcohol and being condensed into 50-60 DEG C, separately takes the starch and 0.7% of medicinal extract amount 30% Magnesium stearate and medicinal extract mix, with 60% alcohol granulation, dry, pulverize, fill capsule to get capsule.
Specification: 0.3g/.
Usage and dosage: each 5-10g, it is 2-3 times daily.
Embodiment 3.
Formula: Herba Cistanches 10kg, Fructus Fici Beecheyanae 10kg, tremella 20kg, accumulated snow 30kg, agaric 10kg, Radix Ophiopogonis 20kg, fructus lycii 10kg, Radix Glycyrrhizae 30kg and Mesona chinensis Benth 30kg.
Technique: taking said medicine, and 10 times of amount water is added to decoct 3 times, each 1.5h, and filtering merges decoction liquor, is condensed into 50- Relative density is the starch mixing of the medicinal extract of 1.15-1.20, medicinal extract and above-mentioned mixed powder and medicinal extract amount 20%, tabletting, packet at 60 DEG C Film-coating is to get tablet.
Specification: 0.3g/ piece.
Usage and dosage: each 5-10g, it is 2-3 times daily.

Claims (8)

1. a kind of drug for treating diarrhea, it is characterised in that: calculate by weight, mainly by 1-20 parts of Herba Cistanches, Fructus Fici Beecheyanae 1- 20 parts, 10-30 parts of tremella, 20-40 parts of folium panacis japonici cum caule, 1-20 parts of agaric, Radix Ophiopogonis 10-30 part, 1-20 parts of fructus lycii, Radix Glycyrrhizae 20-40 Part is made with Mesona chinensis Benth 20-40 parts.
2. the drug for the treatment of diarrhea as described in claim 1, it is characterised in that: calculate by weight, mainly by Herba Cistanches 5- 15 parts, 5-15 parts of Fructus Fici Beecheyanae, 15-25 parts of tremella, 25-35 parts of accumulated snow, 5-15 parts of agaric, Radix Ophiopogonis 15-25 part, fructus lycii 5-15 Part, 25-35 parts of Radix Glycyrrhizae and 25-35 parts of Mesona chinensis Benth are made.
3. the drug for the treatment of diarrhea as claimed in claim 2, it is characterised in that: calculate by weight, mainly by Herba Cistanches 10 Part, 10 parts of Fructus Fici Beecheyanae, 20 parts of tremella, 30 parts of accumulated snow, 10 parts of agaric, 20 parts of Radix Ophiopogonis, 10 parts of fructus lycii, 30 parts of Radix Glycyrrhizae and Mesona chinensis Benth 30 parts are made.
4. a kind of production method of the drug for the treatment of diarrhea as claimed in any one of claims 1-3, it is characterised in that: take Drug is stated, auxiliary material can be added, auxiliary material can also be not added, oral preparation is made.
5. the production method of the drug for the treatment of diarrhea as claimed in claim 4, it is characterised in that: the oral preparation is particle Agent, capsule, tablet, pill, powder or creme.
6. the production method of the drug for the treatment of diarrhea as claimed in claim 5, it is characterised in that: the granule is made in this way Make: taking said medicine, 10 times of amount water is added to decoct 3 times, each 1.5h, filtering merges decoction liquor, is condensed into opposite at 50-60 DEG C Density is the medicinal extract of 1.15-1.20, the starch of medicinal extract and medicinal extract amount 20% and 20% dextrine powder mixing granulation, it is dry to get.
7. the production method of the drug for the treatment of diarrhea as claimed in claim 5, it is characterised in that: the production side of the capsule Method are as follows: take said medicine, extracted 2 times with the alcohol reflux of 6 times of amounts 70%, 1 hour every time, extracting solution filtered, filtrate recycling ethanol And relative density is the medicinal extract of 1.20-1.25 when being condensed into 50-60 DEG C, separately takes the starch of medicinal extract amount 30% and 0.7% stearic acid Magnesium and medicinal extract mix, and with 60% alcohol granulation, dry, pulverize, fill capsule to get.
8. the production method of the drug for the treatment of diarrhea as claimed in claim 5, it is characterised in that: the production method of the tablet Are as follows: said medicine is taken, 10 times of amount water is added to decoct 3 times, each 1.5h, filtering merges decoction liquor, is condensed into opposite at 50-60 DEG C Density is the medicinal extract of 1.15-1.20, and medicinal extract is mixed with above-mentioned mixed powder and the starch of medicinal extract amount 20%, tabletting, film coating, i.e., ?.
CN201710847111.XA 2017-09-19 2017-09-19 A kind of drug and preparation method thereof for treating diarrhea Pending CN109512933A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201710847111.XA CN109512933A (en) 2017-09-19 2017-09-19 A kind of drug and preparation method thereof for treating diarrhea

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201710847111.XA CN109512933A (en) 2017-09-19 2017-09-19 A kind of drug and preparation method thereof for treating diarrhea

Publications (1)

Publication Number Publication Date
CN109512933A true CN109512933A (en) 2019-03-26

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Family Applications (1)

Application Number Title Priority Date Filing Date
CN201710847111.XA Pending CN109512933A (en) 2017-09-19 2017-09-19 A kind of drug and preparation method thereof for treating diarrhea

Country Status (1)

Country Link
CN (1) CN109512933A (en)

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Application publication date: 20190326

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