CN104147229A - Traditional Chinese medicine compound preparation for treating female climacteric syndrome kidney yin-yang deficiency type - Google Patents
Traditional Chinese medicine compound preparation for treating female climacteric syndrome kidney yin-yang deficiency type Download PDFInfo
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- CN104147229A CN104147229A CN201410422183.6A CN201410422183A CN104147229A CN 104147229 A CN104147229 A CN 104147229A CN 201410422183 A CN201410422183 A CN 201410422183A CN 104147229 A CN104147229 A CN 104147229A
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- climacteric syndrome
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Abstract
The invention relates to a traditional Chinese medicine composition and a compound preparation for treating female climacteric syndrome kidney yin-yang deficiency type. The traditional Chinese medicine composition and the compound preparation are composed of 333g of epimedium, 333g of radix rehmanniae praeparata, 333g of prepared polygonum multiflorum, 333g of angelica sinensis, 166.5g of armeniaca mume, 166.5g of canavalia sericea, 166.5g of albizzia julibrissin, 166.5g of herba leonuri and 166.5g of schisandra chinensis. A preparation method includes following steps: employing the epimedium, the prepared polygonum multiflorum, the schisandra chinensis and the angelica sinensis; adding 6 times amount of 70% ethanol; performing reflux extraction for 2 times with each reflux extraction lasting for 1.5 hours; mixing filtrates to obtain an ethanol extract; decocting medicine residues and other five medicines for 2 times with addition of water, wherein each decocting operation lasts for 2 hours; mixing filtrates; concentrating the mixed filtrates to form a clear paste of which a relative density is 1.15 at 60 DEG C; adding ethanol to enable the content of the ethanol to be 60%; allowing the clear paste to stand for precipitating; mixing a supernate and the ethanol extract; performing reduced pressure concentration to form a thick paste of which the relative density is 1.30 at 60 DEG C; performing a reduced pressure drying process and a crushing process; adding auxiliary materials with mixing uniformly; carrying out a granulating process; and filling capsules with prepared granules to obtain the traditional Chinese medicine composition and the compound preparation. The composition and the compound preparation have effects of nourishing yin and tonifying yang, and regulating chong meridian and ren meridian.
Description
Technical field
The present invention relates to a kind of compositions and compound Chinese medicinal preparation for the treatment of female climacteric syndrome kidney yin and yang deficiency type, for female climacteric syndrome kidney yin and yang deficiency type disease, see: dizziness and tinnitus, forgetful, how cold how hot, face is warmed, perspiration and aversion to wind, soreness of the waist and knees, red tongue with thin fur, arteries and veins cone number.
Background technology
Climacteric syndrome claims again " perimenopausal syndrome ", it is hypo-ovaria before and after postmenopausal women, sexual hormone disturbance or decline due to neuroendocrine imbalance, thereby occur that reproductive system changes and a series of autonomic nervous dysfunction of take is main syndrome group, belong to traditional Chinese medical science menopausal syndrome, also claim " all cards before and after cracked ends ".How because madam is in year of seventy-seven, kidney qi degradation, the conception vessel void that declines, taichong channel declines few, menses will exhaust, asthenia of essence and blood, imbalance of YIN and YANG and the function that causes is not normal, conventionally can show as and warm that sweating, flushing hectic fever, irritated irritability, feelings will are indefinite, palpitation and insomnia, dizziness and tinnitus, puffiness of the face and limbs, back are miserable etc.According to statistics, China's climacteric women number approximately 1.3 hundred million of living in now, and at climacteric, there is related symptoms in 100,000,000 more than, 85% the women of reaching who wherein suffers from climacteric syndrome, part even has influence on its quality of life.We take from Wuxue City clinical practice for many years through proved recipe, take Herba Epimedii as monarch drug, adopt multi-medicament composition of prescription, Bing Jing Yaogu Sci-Tech Development Co., Ltd., Wuhan is by existing new drug requirements of customs declaration, preferred formulation moulding process, develop Chinese medicine, natural drug new drug six class Herba Leonuri climacteric recovering capsules, Fang Zhongshi simply medical material has been imperial medical material, not containing drug toxicity and eighteen incompatible medicaments, the medicine of the incompatibilitys such as nineteen medicaments of mutual restraint, its reasonable recipe, there is treating both the principal and secondary aspects of a disease, easy to use, quality controllable, drug effect is definite, safe and reliable advantage, can meet the demand of extensive patients.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of compositions and compound Chinese medicinal preparation for the treatment of female climacteric syndrome kidney yin and yang deficiency type, and this medicine has nourishing YIN and invigorating YANG, Chong and Ren Meridians regulating.For before and after menopause, dizziness and tinnitus, forgetful, how cold how hot, face is warmed, perspiration and aversion to wind, soreness of the waist and knees, red tongue with thin fur, arteries and veins cone number.
Medicine of the present invention is made by the raw material of Chinese medicine of following weight proportioning:
Herba Epimedii 166.5 ~ 499.5g FLOS MUME 55.5 ~ 277.5g Radix Rehmanniae Preparata 166.5 ~ 499.5g
Fructus Schisandrae Chinensis 55.5 ~ 277.5g Radix Polygoni Multiflori Preparata 166.5 ~ 499.5g Sword Jackbean Seed 55.5 ~ 277.5g
Radix Angelicae Sinensis 166.5 ~ 499.5g Flos Albiziae 55.5 ~ 277.5g Herba Leonuri 55.5 ~ 277.5g
The preferred weight proportioning of each raw material of the present invention is:
Herba Epimedii 277.5 ~ 388.5g FLOS MUME 111 ~ 222g Radix Rehmanniae Preparata 277.5 ~ 388.5g
Fructus Schisandrae Chinensis 111 ~ 222g Radix Polygoni Multiflori Preparata 277.5 ~ 388.5g Sword Jackbean Seed 111 ~ 222g
Radix Angelicae Sinensis 277.5 ~ 388.5g Flos Albiziae 111 ~ 222g Herba Leonuri 111 ~ 222g
The optimum weight proportioning of each raw material of the present invention is:
Herba Epimedii 333g FLOS MUME 166.5g Radix Rehmanniae Preparata 333g
Fructus Schisandrae Chinensis 166.5g Radix Polygoni Multiflori Preparata 333g Sword Jackbean Seed 166.5g
Radix Angelicae Sinensis 333g Flos Albiziae 166.5g Herba Leonuri 166.5g
Preparation method of the present invention is: above ten simply, gets Herba Epimedii, Radix Polygoni Multiflori Preparata, Fructus Schisandrae Chinensis, Radix Angelicae Sinensis, adds 6 times of amounts of 70% ethanol, reflux, extract, 2 times, and each 1.5 hours, merging filtrate, filtered, and obtains alcohol extract; Medicinal residues and all the other 5 taste medicines decoct with water twice, and each 2 hours, decocting liquid filtered, merging filtrate, the clear paste that while being concentrated into 60 ℃, relative density is 1.15, adds ethanol and makes to reach 60% containing alcohol amount, the standing precipitation that makes, gets supernatant and above-mentioned alcohol extract and merges, the thick paste that when reclaiming ethanol and being evaporated to 60 ℃, relative density is 1.30,80 ℃ of drying under reduced pressure, pulverize, and add appropriate amount of auxiliary materials, mix, granulate, incapsulate, obtain.
Medicine of the present invention can add one or more pharmaceutic adjuvants as required, pharmaceutic adjuvant can be diluent, binding agent, correctives, excipient, as sucrose, dextrin, starch, lactose, xylitol, mannitol, sorbitol, soluble starch, microcrystalline Cellulose, aspartame, steviosin, magnesium stearate, micropowder silica gel.
The present invention can make any clinical pharmaceutical preparation that is applicable to according to existing process of Chinese medicine preparation, comprises solid preparation (hard capsule, granule, tablet, dispersible tablet, soft capsule, drop pill, pill), liquid preparation (syrup, soft extract, oral liquid, mixture) etc.The preferred dosage form of the present invention is capsule, tablet.
The present invention is formed by ten a herb prescriptions, and Herba Epimedii acrid, sweet, warm in side, return liver, kidney channel, have kidney-replenishing effect, are to be monarch drug; Radix Rehmanniae Preparata is sweet, and tepor is returned liver, kidney channel, has the YIN nourishing of enriching blood and Herba Epimedii is all monarch drug, together brings into play the effect of nourishing YIN and invigorating YANG; Radix Polygoni Multiflori Preparata is bitter, sweet, puckery, and tepor is returned liver, the heart, kidney channel, has the ministerial drug that act as of nourishing the liver and kidney, the nourishing the liver of principal drug assistance kidney tonifying; Sword Jackbean Seed is sweet, and temperature is returned stomach, kidney channel, the effect of tool kidney tonifying complement; Schizandronic acid, sweet, temperature, returns lung, the heart, kidney channel, the effect of tool kidney calming; Flos Albiziae is sweet, flat, GUIXIN, Liver Channel, and energy nourishing kidney-yin, is all adjuvant drug with Sword Jackbean Seed, Radix Schisandrae Bicoloris, altogether the merit of principal drug assistance performance the kidney invigorating; Radix Angelicae Sinensis sweet, acrid, warm, returns liver, the heart, spleen channel, has the effectiveness of menstruction regulating and pain relieving, except helping the monarch and his subjects will bring into play the effect of the liver benefiting, also by nourishing " the foundation of acquired constitution ", reaches the object of YIN nourishing; FLOS MUME acid, puckery, flat, return liver, spleen, lung, large intestine channel, energy dispersing the stagnated live-QI to relieve the stagnation of QI; Radix Angelicae Sinensis and FLOS MUME are all adjuvant drug, together reach that tonifying liver is soothing the liver, the effect of kidney tonifying YIN nourishing in side; Herba Leonuri is bitter, pungent, is slightly cold, and returns liver, pericardium, urinary bladder channel, has promoting blood flow to regulate menstruation effect, and its property is cold, can anti-side in other property of medicine excessively dry, in itself and the Radix Cynanchi Atrati side of being all, make medicine.Full side plays nourishing YIN and invigorating YANG, the merit of Chong and Ren Meridians regulating altogether.For before and after menopause, dizziness and tinnitus, forgetful, how cold how hot, face is warmed, perspiration and aversion to wind, soreness of the waist and knees, red tongue with thin fur, arteries and veins cone number.
The climacteric syndrome model that pharmacodynamic experiment is set up by extracing rat both sides ovary, take diethylstilbestrol tablet, GENGNIANAN PIAN is contrast, and gavage is after 30 days, and result shows that Herba Leonuri climacteric recovering capsule can increase rat uterus weight, improve estrogen (SE
2) level, luteotropic hormone (LH) level that reduces, prompting Herba Leonuri climacteric recovering capsule can improve climacteric syndrome symptom.And the application of facing by hospital to kidney yin and yang deficiency type climacteric syndrome 158 routine patients, serum SE after discovery patient medication
2level significantly improves, and FSH level obviously declines (P<0.5), has statistical significance; And the total effective rate that the symptoms such as patient's soreness of the waist and knees, dry mouth and throat, headache and dizziness, Hiccough and deaf are improved is 87.6%, illustrates that this capsule clinical effectiveness is satisfactory.
An important feature of the present invention is pure Chinese medicinal preparation, and determined curative effect, toxic and side effects are little, forms the place of the through disease of drug effect by motherland's traditional medicine prescription.Meanwhile, after preparations shaping, facilitated carrying and taking of patient, and quality controllable, safety good.
The specific embodiment
By the following specific embodiment, realize and further illustrating of the present invention, but should not be understood to any limitation of the invention.
Press column weight amount and take raw material:
Herba Epimedii 333g FLOS MUME 166.5g Radix Rehmanniae Preparata 333g
Fructus Schisandrae Chinensis 166.5g Radix Polygoni Multiflori Preparata 333g Sword Jackbean Seed 166.5g
Radix Angelicae Sinensis 333g Flos Albiziae 166.5g Herba Leonuri 166.5g
Preparation method: above ten simply, gets Herba Epimedii, Radix Polygoni Multiflori Preparata, Fructus Schisandrae Chinensis, Radix Angelicae Sinensis, adds 6 times of amounts of 70% ethanol, reflux, extract, 2 times, and each 1.5 hours, filter, merging filtrate, obtains alcohol extract; Medicinal residues and all the other 5 taste medicines decoct with water twice, and each 2 hours, decocting liquid filtered, merging filtrate, the clear paste that while being concentrated into 60 ℃, relative density is 1.15, adds ethanol and makes to reach 60% containing alcohol amount, the standing precipitation that makes, gets supernatant and above-mentioned alcohol extract and merges, the thick paste that when reclaiming ethanol and being evaporated to 60 ℃, relative density is 1.30,80 ℃ of drying under reduced pressure, pulverize, and add appropriate amount of auxiliary materials, mix, granulate, incapsulate, obtain.
Claims (5)
1. treat compositions and the compound Chinese medicinal preparation of female climacteric syndrome kidney yin and yang deficiency type, it is characterized in that it is to be made by the raw material of Chinese medicine of following weight proportion:
Herba Epimedii 333g FLOS MUME 166.5g Radix Rehmanniae Preparata 333g
Fructus Schisandrae Chinensis 166.5g Radix Polygoni Multiflori Preparata 333g Sword Jackbean Seed 166.5g
Radix Angelicae Sinensis 333g Flos Albiziae 166.5g Herba Leonuri 166.5g.
2. compositions and the compound Chinese medicinal preparation for the treatment of female climacteric syndrome kidney yin and yang deficiency type according to claim 1, it is characterized in that preparation method is: above ten simply, get Herba Epimedii, Radix Polygoni Multiflori Preparata, Fructus Schisandrae Chinensis, Radix Angelicae Sinensis, add 6 times of amounts of 70% ethanol, reflux, extract, 2 times, each 1.5 hours, merging filtrate, filter, obtain alcohol extract; Medicinal residues and all the other 5 taste medicines decoct with water twice, and each 2 hours, decocting liquid filtered, merging filtrate, the clear paste that while being concentrated into 60 ℃, relative density is 1.15, adds ethanol and makes to reach 60% containing alcohol amount, the standing precipitation that makes, gets supernatant and above-mentioned alcohol extract and merges, the thick paste that when reclaiming ethanol and being evaporated to 60 ℃, relative density is 1.30,80 ℃ of drying under reduced pressure, pulverize, and add appropriate amount of auxiliary materials, mix, granulate, incapsulate, obtain.
3. a kind of compositions and compound Chinese medicinal preparation for the treatment of female climacteric syndrome kidney yin and yang deficiency type according to claim 2, wherein appropriate amount of auxiliary materials is diluent, binding agent, correctives, excipient.
4. a kind of compositions and compound Chinese medicinal preparation for the treatment of female climacteric syndrome kidney yin and yang deficiency type according to claim 2, wherein adjuvant is one or more in sucrose, dextrin, starch, lactose, xylitol, mannitol, sorbitol, soluble starch, microcrystalline Cellulose, aspartame, steviosin, magnesium stearate, micropowder silica gel.
5. a kind of compositions and compound Chinese medicinal preparation for the treatment of female climacteric syndrome kidney yin and yang deficiency type according to claim 2, wherein preparation is a kind of in granule, tablet, soft extract, capsule, mixture, syrup, pill.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105477264A (en) * | 2015-12-16 | 2016-04-13 | 青岛麦瑞特医药技术有限公司 | Medicinal preparation for treating urethral syndrome |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102908539A (en) * | 2011-08-04 | 2013-02-06 | 苏吉永 | Traditional Chinese medicine for treating menopausal night sweats and preparation method of same |
| CN103169881A (en) * | 2012-12-28 | 2013-06-26 | 青岛华仁信息技术开发有限公司 | Chinese medicament health product for supplementing female hormone for women during menopause and preparation method thereof |
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- 2014-08-26 CN CN201410422183.6A patent/CN104147229B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102908539A (en) * | 2011-08-04 | 2013-02-06 | 苏吉永 | Traditional Chinese medicine for treating menopausal night sweats and preparation method of same |
| CN103169881A (en) * | 2012-12-28 | 2013-06-26 | 青岛华仁信息技术开发有限公司 | Chinese medicament health product for supplementing female hormone for women during menopause and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 王昃睿等: "王治强治疗更年期综合征经验", 《中医杂志》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105477264A (en) * | 2015-12-16 | 2016-04-13 | 青岛麦瑞特医药技术有限公司 | Medicinal preparation for treating urethral syndrome |
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