CN100998696A - Traditional Chinese medicine composition for treating throat disease and its preparing method - Google Patents
Traditional Chinese medicine composition for treating throat disease and its preparing method Download PDFInfo
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Abstract
A Chinese medicine for treating throat diseases is prepared from 12 Chinese-medicinal materials including bezoar, isatis root, platycodon root, forysythia fruit, etc. Its preparing process is also disclosed.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, particularly be used for the treatment of the Chinese medicine composition of laryngopharyngeal diseases, the invention still further relates to the preparation method of this Chinese medicine composition.
Technical background
The tradition traditional Chinese medical science is thought " all diseases of throat all belong to fire ", and modern medicine thinks that tonsillitis, laryngopharyngeal diseasess such as acute and chronic pharyngitis are the microbial infection of cause of disease such as antibacterial, virus.The sickness rate height of laryngopharyngeal diseases, the patient is very painful, does not still have good Therapeutic Method and medicine both at home and abroad.
Compositions of the present invention show by various experimentatioies have analgesic, analgesia, the effect of antiinflammatory and broad-spectrum antiseptic, the throat common disease is had good curative effect.
Summary of the invention
The objective of the invention is to disclose and a kind ofly can effectively treat Chinese medicine composition of laryngopharyngeal diseases and preparation method thereof.The present invention is through lot of experiments, investigation by to every pharmacy indexs such as pharmaceutical chemistry, pharmaceutics, Pharmaceutical Analysis has made creative prescription and production technology, under the condition that has guaranteed quality, the needs that met big production more have very strong industrial applicibility.
The present invention can be achieved through the following technical solutions:
The Chinese medicine composition of treatment laryngopharyngeal diseases of the present invention comprises following parts by weight of raw materials:
180～280 parts of 220～330 parts of terminalia flesh of 13～20 parts of Radix Isatidis of Calculus Bovis
37～55 parts of Fructus Forsythiaes 180～280 of 220～330 parts of Fructus Gleditsiae Abnormalis of Radix Platycodonis
220～330 parts of 13～20 parts of Radix Eupatorii Chinensiss of 370～550 parts of Margarita layer powder of Radix Trichosanthis
370～550 parts of 370～550 parts of Radix Wikstroemae of 13～20 parts of Radix Sophorae Tonkinensiss of Borneolum Syntheticum
Preferred weight part proportioning of raw material of Chinese medicine of the present invention is:
231 parts of 277 parts of terminalia flesh of 16.8 parts of Radix Isatidis of Calculus Bovis
231 parts of 46 parts of Fructus Forsythiaes of 277 parts of Fructus Gleditsiae Abnormalis of Radix Platycodonis
277 parts of 16.8 parts of Radix Eupatorii Chinensiss of 462 parts of Margarita layer powder of Radix Trichosanthis
462 parts of 462 parts of Radix Wikstroemae of 16.8 parts of Radix Sophorae Tonkinensiss of Borneolum Syntheticum
The present invention also provides this Chinese medicine composition, can be again mixes with acceptable adjuvant pharmaceutically, makes the pharmaceutical dosage form of various treatment laryngopharyngeal diseasess:
The present invention also provides this Chinese medicine composition to make a kind of medicament capsule for the treatment of laryngopharyngeal diseases.
The present invention also provides this Chinese medicine composition to make a kind of drug port buccal tablet for the treatment of laryngopharyngeal diseases.
The preferred filler of said composition buccal tablet provided by the present invention is an Icing Sugar, and correctives is an Oleum menthae, and lubricant is a magnesium stearate.
The present invention also provides the weight portion of the preferred adjuvant of buccal tablet of said composition: Icing Sugar is that 700～1300 parts, Oleum menthae are that 6～10 parts, magnesium stearate are 12～30 parts.
The best adjuvant preferred weight of said composition buccal tablet provided by the present invention part is: Icing Sugar is that 1000 parts, Oleum menthae are that 7.68 parts, magnesium stearate are 15 parts.
The present invention also provides the preparation method of described medicament capsule:
A. terminalia flesh is ground into fine powder.
B. Borneolum Syntheticum porphyrize, with Calculus Bovis and Margarita layer powder mixing, as after go into medicated powder.
C. Radix Isatidis, Radix Platycodonis, Fructus Gleditsiae Abnormalis, Fructus Forsythiae, Radix Trichosanthis, Radix Eupatorii Chinensis, Radix Sophorae Tonkinensis and Radix Wikstroemae add the water of 5～8 times of amounts, decoct twice, and each 2 hours, merge extractive liquid, filtered.Filtrate is condensed into extractum, gets 75%～95% ethanol and adds in right amount in the extractum, stirs evenly, and after leaving standstill, gets supernatant concentration and becomes thick paste, adds the terminalia flesh fine powder that step a makes, mixing, and vacuum drying is ground into fine powder.
D. two kinds of powder mixings that step b, c are made incapsulate, promptly.
The present invention also provides the preparation method of described drug port buccal tablet:
A. terminalia flesh water concentration shortens thick paste A into.
B. Radix Isatidis, Radix Platycodonis, Fructus Gleditsiae Abnormalis, Fructus Forsythiae, Radix Trichosanthis, Radix Eupatorii Chinensis, Radix Sophorae Tonkinensis and Radix Wikstroemae add the water of 5～8 times of amounts, decoct twice, and each 2 hours, merge extractive liquid, filtered.Filtrate is condensed into extractum, gets 75%～95% ethanol and adds in right amount in the extractum, stirs evenly, and after leaving standstill, gets supernatant concentration and becomes thick paste B.
C. with thick paste A and B mixing, and add artificial Calculus Bovis and Margarita layer powder, mixing, vacuum drying is ground into fine powder.
D. the Borneolum Syntheticum cyclodextrin inclusion compound is crossed 120 mesh sieves.
E. the fine powder that step c and d are made adds the filler mix homogeneously, adds 80% ethanol and makes soft material in right amount, sieves, and granulates vacuum drying.
F. drying is the good granule granulate that sieves adds correctives, lubricant, mixing, and compacting is in flakes.
Preferred filler is an Icing Sugar in the above-mentioned preparation method, and correctives is that Oleum menthae, lubricant are magnesium stearate.
The further preferred version of adjuvant is Icing Sugar 700～1300 weight portions, Oleum menthae 6～10 weight portions, magnesium stearate 12～30 weight portions in the above-mentioned preparation method.
Best adjuvant preferred weight part is in the above-mentioned preparation method: 1000 parts of Icing Sugar, 7.68 parts of Oleum menthae, magnesium stearate weight portion are 15 parts.
Said medicine buccal tablet preparation method, wherein the independent water of terminalia flesh is carried, and following advantage is arranged:
1. the main effective ingredient of terminalia flesh has promptly been preserved in the medical material generation chemical reaction that can not carry with other water of compositions such as tannin in the terminalia flesh and gallic acid and a large amount of loss, and curative effect is more remarkable.
2. the whole pulverizing of the terminalia flesh dose that is used as medicine is big, extracts the back effective ingredient and still is kept in the extracting solution, but be used as medicine behind the extract dry after concentrating, and dose reduces.
The concrete extracting method of terminalia flesh is: add the water of 5～15 times of amounts, boiled 0.5～2 hour, extract 1～5 time.
The further preferred version of above-mentioned preparation method is: add the water of 12 times of amounts, soaked 0.5 hour, boiled 0.5 hour, leach extracting solution; Medicinal residues add 10 times of water gagings and boiled 0.5 hour again, leach extracting solution; Medicinal residues add 10 times of water gagings again and boiled 0.5 hour, and merge extractive liquid, is condensed into thick paste.
Among the preparation technology of this Chinese medicine composition buccal tablet provided by the invention with the Borneolum Syntheticum cyclodextrin inclusion compound.
Borneolum Syntheticum of the present invention with the cyclodextrin inclusion compound selection process is: the Borneolum Syntheticum beta-cyclodextrin inclusion compound; Press following weight portion proportioning: pure water: beta-schardinger dextrin-: Borneolum Syntheticum=60～95: 5～7.5: 1, get pure water, beta-schardinger dextrin-is put in the container, be heated to 55～65 ℃ and stir and to make dissolving fully, under agitation add Borneolum Syntheticum alcoholic solution (95% ethanol: Borneolum Syntheticum=1～3: 1), stirred 1～3 hour fast, leave standstill and made to room temperature in 2～4 hours, sucking filtration, filtering residue is drained filtering residue with an amount of washing of 95% ethanol 2 times, 50 ℃ of dryings 3～5 hours were pulverized 120 mesh sieves.
Beneficial effect
Four kinds of diseases such as the acute throat of traditional Chinese medicine composition for treating provided by the present invention are all effective.Acute pharyngitis, tonsillitis, parotitic clinical cure rate are 30.1%, and total effective rate is 92.2%; Obvious effective rate to treatment chronic pharyngitis or acute attack stage is 40.4%, and total effective rate is 85.1%.
In above technical scheme, we have verified that by experiment said composition is with respect to WS in the 5th of the ministry standard
3The prescription and the method for making of-B-1039-91 larynx disease curing capsule have marked improvement:
Larynx disease curing capsule prescription and preparation method:
231 parts of 277 parts of Fructus Chebulaes of 16.8 parts of Radix Isatidis of Calculus Bovis
231 parts of 46 parts of Fructus Forsythiaes of 277 parts of Fructus Gleditsiae Abnormalis of Radix Platycodonis
277 parts of 16.8 parts of Radix Eupatorii Chinensiss of 462 parts of Margarita layer powder of Radix Trichosanthis
462 parts of 462 parts of Radix Wikstroemae of 16.8 parts of Radix Sophorae Tonkinensiss of Borneolum Syntheticum
More than 12 the flavor, the Borneolum Syntheticum porphyrize is with Calculus Bovis and Margarita layer powder mixing; Terminalia flesh is ground into fine powder; Semen Chebulae and all the other eight flavors decoct with water secondary, and collecting decoction filters, and is condensed into thick paste, add the ethanol qdx after cold, stir evenly, standing over night is drawn supernatant, filter, filtering residue 75% washing with alcohol filters merging filtrate, reclaim ethanol, be condensed into thick paste after, add Fructus Chebulae powder, mixing, drying is pulverized, sieve, add all the other powder, mixing.Incapsulate, promptly.
Compositions of the present invention, change the Fructus Chebulae into terminalia flesh, originally " Semen Chebulae and all the other eight flavors decoct with water secondary " changes " Radix Isatidis, Radix Platycodonis, Fructus Gleditsiae Abnormalis, Fructus Forsythiae, Radix Trichosanthis, Radix Eupatorii Chinensis, Radix Sophorae Tonkinensis and Radix Wikstroemae decoct with water secondary " into, removed the water of Semen Chebulae and carried, according to as follows:
(1) variation of effective ingredient
Main component is a tannin in the Semen Chebulae, and content is up to 23%～37%, and modern pharmacology research simultaneously illustrates that one of main effective ingredient is a gallic acid among the Fructus Chebulae.Radix Sophorae Tonkinensis mainly contains alkaloid in the prescription, medical material main component such as Radix Platycodonis, Fructus Gleditsiae Abnormalis, Fructus Forsythiae, Radix Trichosanthis, Radix Eupatorii Chinensis and Semen Chebulae the water effective ingredient of carrying the various medical materials in back simultaneously have loss, generate precipitation as trichosanthin and tannin reaction, be removed behind the water extract-alcohol precipitation; Radix Sophorae Tonkinensis mainly contains alkaloid and Semen Chebulae also can partly generate precipitation with after carrying, and content reduces.
(2) change of character
The powder that incapsulates is loose with character, good fluidity, and it is good being difficult for the moisture absorption.The present invention uses terminalia flesh complete wear powder to be used as medicine, and becomes good absorbent, and has reduced the extractum amount relatively, and character, flowability, moisture absorption etc. all have improvement, is fit to actual big production needs more.By contrast, experimental data sees Table one:
Table one character pair ratio
| Testing index | Compositions of the present invention | Larynx disease curing capsule |
| Mobile (angle of repose) | 43.5° | 47.4° |
| Moisture absorption | Reveal after empty 2 hours and still loosen, easily incapsulate | Reveal empty 30 minutes rear section bonding in bulk, be difficult to incapsulate |
Prepared medicament capsule is with respect to WS in the 5th of the ministry standard
3-B-1039-91 larynx disease curing capsule has and keeps effective ingredient, medicine implant good fluidity, advantage such as nonhygroscopic, is applicable to the preservation of medicine.
The drug port buccal tablet of said composition is the advantage of Borneolum Syntheticum enclose and adding Oleum menthae: the abnormal smells from the patient of Borneolum Syntheticum is not good, and its mouthfeel of back of being used as medicine is difficult to be accepted by the patient, now by the technology of Borneolum Syntheticum enclose, has covered the bad smell of Borneolum Syntheticum.In addition, medical material taste bitternesses such as Radix Sophorae Tonkinensis, Radix Trichosanthis, the present invention has covered all bad mouthfeels to greatest extent by adding adjuvants such as Oleum menthae, Icing Sugar, success first made the buccal tablet that mouthfeel can be accepted by masses, curative effect is rapid, acts on more directly, and has made things convenient for taking of patient.
Specific embodiment
Below further specify the present invention by specific embodiment, but do not limit the present invention in any form.
Embodiment 1
231 parts of 277 parts of terminalia flesh of 16.8 parts of Radix Isatidis of Calculus Bovis
231 parts of 46 parts of Fructus Forsythiaes of 277 parts of Fructus Gleditsiae Abnormalis of Radix Platycodonis
277 parts of 16.8 parts of Radix Eupatorii Chinensiss of 462 parts of Margarita layer powder of Radix Trichosanthis
462 parts of 462 parts of Radix Wikstroemae of 16.8 parts of Radix Sophorae Tonkinensiss of Borneolum Syntheticum
Terminalia flesh is ground into fine powder.The Borneolum Syntheticum porphyrize, with Calculus Bovis and Margarita layer powder mixing, as after go into medicated powder.Radix Isatidis, Radix Platycodonis, Fructus Gleditsiae Abnormalis, Fructus Forsythiae, Radix Trichosanthis, Radix Eupatorii Chinensis, Radix Sophorae Tonkinensis and Radix Wikstroemae add the water of 8 times of amounts, decoct twice, and each 2 hours, merge extractive liquid, filtered.Filtrate is condensed into extractum, gets 75% ethanol and adds in right amount in the extractum, stirs evenly, and after leaving standstill, gets supernatant concentration and becomes thick paste, adds the terminalia flesh fine powder, mixing, and vacuum drying is ground into fine powder, goes into medicated powder after adding again, and mixing incapsulates, promptly.
Embodiment 2
180 parts of 220 parts of terminalia flesh of 13 parts of Radix Isatidis of Calculus Bovis
180 parts of 37 parts of Fructus Forsythiaes of 220 parts of Fructus Gleditsiae Abnormalis of Radix Platycodonis
220 parts of 13 parts of Radix Eupatorii Chinensiss of 370 parts of Margarita layer powder of Radix Trichosanthis
370 parts of 370 parts of Radix Wikstroemae of 13 parts of Radix Sophorae Tonkinensiss of Borneolum Syntheticum
Terminalia flesh is ground into fine powder.The Borneolum Syntheticum porphyrize, with Calculus Bovis and Margarita layer powder mixing, as after go into medicated powder.Radix Isatidis, Radix Platycodonis, Fructus Gleditsiae Abnormalis, Fructus Forsythiae, Radix Trichosanthis, Radix Eupatorii Chinensis, Radix Sophorae Tonkinensis and Radix Wikstroemae add the water of 5 times of amounts, decoct twice, and each 2 hours, merge extractive liquid, filtered.Filtrate is condensed into extractum, gets 85% ethanol and adds in right amount in the extractum, stirs evenly, and after leaving standstill, gets supernatant concentration and becomes thick paste, adds the terminalia flesh fine powder, mixing, and vacuum drying is ground into fine powder, goes into medicated powder after adding again, and mixing incapsulates, promptly.
Embodiment 3
280 parts of 330 parts of terminalia flesh of 20 parts of Radix Isatidis of Calculus Bovis
280 parts of 55 parts of Fructus Forsythiaes of 330 parts of Fructus Gleditsiae Abnormalis of Radix Platycodonis
330 parts of 20 parts of Radix Eupatorii Chinensiss of 550 parts of Margarita layer powder of Radix Trichosanthis
550 parts of 550 parts of Radix Wikstroemae of 20 parts of Radix Sophorae Tonkinensiss of Borneolum Syntheticum
Radix Isatidis, Radix Platycodonis, Fructus Gleditsiae Abnormalis, Fructus Forsythiae, Radix Trichosanthis, Radix Eupatorii Chinensis, Radix Sophorae Tonkinensis and Radix Wikstroemae add the water of 8 times of amounts, decoct twice, and each 2 hours, merge extractive liquid, filtered.Filtrate is condensed into extractum, gets 75% ethanol and adds in right amount in the extractum, stirs evenly, and after leaving standstill, gets supernatant concentration and becomes thick paste A.
Terminalia flesh adds the water of 12 times of amounts, soaks 0.5 hour, boils 45 minutes, leaches extracting solution; Medicinal residues add 10 times of water gagings again, boil 45 minutes, and merge extractive liquid, is condensed into thick paste B.With thick paste A and B mixing, add artificial Calculus Bovis, Margarita layer powder, mix homogeneously, vacuum drying is ground into fine powder.
The Borneolum Syntheticum beta-cyclodextrin inclusion compound, by following weight portion proportioning: pure water: beta-schardinger dextrin-: Borneolum Syntheticum=80: 6: 1, get pure water, beta-schardinger dextrin-is put in the container, be heated to 55～65 ℃ and stir and make dissolving fully, under agitation add Borneolum Syntheticum alcoholic solution (95% ethanol: Borneolum Syntheticum=2: 1) fast, stirred 2 hours, and left standstill and made to room temperature sucking filtration in 3 hours, filtering residue washs 2 times with 95% ethanol is an amount of, drain filtering residue, 50 ℃ of dryings 4 hours were pulverized 120 mesh sieves.
Get the dried cream fine powder of 11 flavor medical materials (removing Borneolum Syntheticum), Borneolum Syntheticum clathrate, 1300 parts of mix homogeneously of Icing Sugar in the above prescription, add 80% ethanol and make soft material in right amount, 16 mesh sieves are granulated, dry 2.5 hours, granulate adds 10 parts of Oleum menthae mixings of particle weight, adds 25 parts of magnesium stearate mix homogeneously again, tabletting, promptly.
Embodiment 4
231 parts of 277 parts of terminalia flesh of 16.8 parts of Radix Isatidis of Calculus Bovis
231 parts of 46 parts of Fructus Forsythiaes of 277 parts of Fructus Gleditsiae Abnormalis of Radix Platycodonis
277 parts of 16.8 parts of Radix Eupatorii Chinensiss of 462 parts of Margarita layer powder of Radix Trichosanthis
462 parts of 462 parts of Radix Wikstroemae of 16.8 parts of Radix Sophorae Tonkinensiss of Borneolum Syntheticum
Radix Isatidis, Radix Platycodonis, Fructus Gleditsiae Abnormalis, Fructus Forsythiae, Radix Trichosanthis, Radix Eupatorii Chinensis, Radix Sophorae Tonkinensis and Radix Wikstroemae add the water of 8 times of amounts, decoct twice, and each 2 hours, merge extractive liquid, filtered.Filtrate is condensed into extractum, gets 75% ethanol and adds in right amount in the extractum, stirs evenly, and after leaving standstill, gets supernatant concentration and becomes thick paste A.
Terminalia flesh adds the water of 12 times of amounts, soaks 0.5 hour, boils 0.5 hour, leaches extracting solution; Medicinal residues extract twice again, add 10 times of water gagings at every turn, boil 0.5 hour, leach extracting solution.Extracting solution is condensed into thick paste B,, adds artificial Calculus Bovis, Margarita layer powder thick paste A and B mixing, mix homogeneously, vacuum drying is ground into fine powder.
The Borneolum Syntheticum beta-cyclodextrin inclusion compound, by following weight portion proportioning: pure water: beta-schardinger dextrin-: Borneolum Syntheticum=85: 6.25: 1, get pure water, beta-schardinger dextrin-is put in the container, be heated to 55～65 ℃ and stir and make dissolving fully, under agitation add Borneolum Syntheticum alcoholic solution (95% ethanol: Borneolum Syntheticum=1.5: 1) fast, stirred 2 hours, and left standstill and made to room temperature sucking filtration in 2～4 hours, filtering residue washs 2 times with 95% ethanol is an amount of, drain filtering residue, 50 ℃ of dryings 3.5 hours were pulverized 120 mesh sieves.
Get the dried cream fine powder of 11 flavor medical materials (removing Borneolum Syntheticum), Borneolum Syntheticum clathrate, 1000 parts of mix homogeneously of Icing Sugar in the above prescription, add 80% ethanol and make soft material in right amount, 16 mesh sieves are granulated, dry 2 hours, granulate adds 7.68 parts of Oleum menthae mixings of particle weight, adds 15 parts of magnesium stearate mix homogeneously again, tabletting, promptly.
Clinical drug efficacy study
Below be after specific embodiments of the invention 1 make capsule 320 routine cases to have been carried out clinical verification, the result is as follows:
One, case data
320 cases that we observe, out-patient's 282 examples wherein, inpatient 38 examples.Gender's ratio is 1: 1.2, and its distribution sees Table two.At minimum 2 years old of age, maximum 74 years old, age cohorts saw Table three.The course of disease is the shortest 1 day, and is the longest 10 years, and the course of disease distributes and sees Table four.
Table two gender distribute (routine number)
Table three age cohorts (routine number)
Table four course of disease distribution (routine number)
Two, administrated method
Adult: oral, one time 4, three times on the one.
The child: below 2 years old each 1～1.5, three times on the one.
2～6 years old children: each 1.5～3, three times on the one.
More than 7 years old: each 3～4, three times on the one.
After mixing thoroughly, puts on the skin the desirable capsule 's content water of parotitis patient in the affected part, and for oral administration simultaneously.
7 days courses of treatment.But two courses of treatment of chronic pharyngitis medication, promptly 14 days.The average natural law of the medication of acute pharyngitis is 5.7 days, and tonsillitis is 5.6 days, and mumps is 5.4 days, and chronic or acute attack is 8.8 days.
Three, efficacy assessment standard
Acute pharyngitis, tonsillitis, parotitis:
1. clinical cure: medication 3 days, body temperature is normal.Disease and shape sign disappear in 5 days.
2. produce effects: medication 3 days, body temperature obviously descends, and symptom and sign disappear substantially in 7 days.
3. effective: medication 3 days, body temperature descends, and symptom and sign partly disappear in 7 days.
4. invalid: medication 3 days, body temperature does not descend, and symptom and sign alleviate not obvious in 7 days.Chronic pharyngitis or acute attack stage:
1. produce effects: symptom obviously alleviates in the medication 7 days.
2. effective: sx in the medication 7 days.
3. invalid: 14 days symptoms of medication and sign do not have obviously and alleviate.
Four, clinical observation result
Curative effect acute pharyngitis, tonsillitis, the parotitic clinical cure rate of four kinds of diseases such as treatment acute pharyngitis are 30.1%, and total effective rate is 92.2%; Obvious effective rate to treatment chronic pharyngitis or acute attack stage is 40.4%, and total effective rate is 85.1%.See table five for details:
Table five clinical efficacy
Claims (16)
1. Chinese medicine composition for the treatment of laryngopharyngeal diseases is characterized in that comprising following parts by weight of raw materials:
180～280 parts of 220～330 parts of terminalia flesh of 13～20 parts of Radix Isatidis of Calculus Bovis
180～280 parts of 37～55 parts of Fructus Forsythiaes of 220～330 parts of Fructus Gleditsiae Abnormalis of Radix Platycodonis
220～330 parts of 13～20 parts of Radix Eupatorii Chinensiss of 370～550 parts of Margarita layer powder of Radix Trichosanthis
370～550 parts of 370～550 parts of Radix Wikstroemae of 13～20 parts of Radix Sophorae Tonkinensiss of Borneolum Syntheticum.
2. Chinese medicine composition according to claim 1 is characterized in that comprising following parts by weight of raw materials:
231 parts of 277 parts of terminalia flesh of 16.8 parts of Radix Isatidis of Calculus Bovis
231 parts of 46 parts of Fructus Forsythiaes of 277 parts of Fructus Gleditsiae Abnormalis of Radix Platycodonis
277 parts of 16.8 parts of Radix Eupatorii Chinensiss of 462 parts of Margarita layer powder of Radix Trichosanthis
462 parts of 462 parts of Radix Wikstroemae of 16.8 parts of Radix Sophorae Tonkinensiss of Borneolum Syntheticum.
3. Chinese medicine composition according to claim 1 and 2 is characterized in that: this Chinese medicine composition, can be again and mixing acceptable accessories, and make the pharmaceutical dosage form of various treatment laryngopharyngeal diseasess.
4. Chinese medicine composition according to claim 3 is characterized in that: this Chinese medicine composition dosage form is a capsule.
5. Chinese medicine composition according to claim 3 is characterized in that: this Chinese medicine composition and filler, correctives, lubricant make the drug port buccal tablet.
6. Chinese medicine composition according to claim 5 is characterized in that, to add filler be Icing Sugar, correctives is an Oleum menthae, lubricant is a magnesium stearate.
7. Chinese medicine composition according to claim 6 is characterized in that, the Icing Sugar weight portion that is added is that 700～1300 parts, Oleum menthae weight portion are that 6～10 parts, magnesium stearate weight portion are 12～30 parts.
8. Chinese medicine composition according to claim 7 is characterized in that, to add the Icing Sugar weight portion be that 1000 parts, Oleum menthae weight portion are that 7.68 parts, magnesium stearate weight portion are 15 parts.
9. the preparation method of the described Chinese medicine composition of claim 4 is characterized in that may further comprise the steps:
A. terminalia flesh is ground into fine powder;
B. Borneolum Syntheticum porphyrize, with Calculus Bovis and Margarita layer powder mixing, as after go into medicated powder;
C. Radix Isatidis, Radix Platycodonis, Fructus Gleditsiae Abnormalis, Fructus Forsythiae, Radix Trichosanthis, Radix Eupatorii Chinensis, Radix Sophorae Tonkinensis and Radix Wikstroemae add the water of 5～8 times of amounts, decoct twice, and each 2 hours, merge extractive liquid, filtered.Filtrate is condensed into extractum, gets 75%～95% ethanol and adds in right amount in the extractum, stirs evenly, and after leaving standstill, gets supernatant concentration and becomes thick paste, adds the terminalia flesh fine powder that step a makes, mixing, and vacuum drying is ground into fine powder;
D. two kinds of powder mixings that step b, c are made incapsulate, promptly.
10. the thing preparation method of the described Chinese medicine composition of claim 5 is characterized in that may further comprise the steps:
A. terminalia flesh water concentration shortens thick paste A into;
B. Radix Isatidis, Radix Platycodonis, Fructus Gleditsiae Abnormalis, Fructus Forsythiae, Radix Trichosanthis, Radix Eupatorii Chinensis, Radix Sophorae Tonkinensis and Radix Wikstroemae add the water of 5～8 times of amounts, decoct twice, and each 2 hours, merge extractive liquid, filtered.Filtrate is condensed into extractum, gets 75%～95% ethanol and adds in right amount in the extractum, stirs evenly, and after leaving standstill, gets supernatant concentration and becomes thick paste B;
C. with thick paste A and B mixing, and add artificial Calculus Bovis and Margarita layer powder, mixing, vacuum drying is ground into fine powder;
D. the Borneolum Syntheticum cyclodextrin inclusion compound is crossed 120 mesh sieves;
E. the fine powder that step c and d are made adds the filler mix homogeneously, adds 80% ethanol and makes soft material in right amount, sieves, and granulates vacuum drying;
F. drying is the good granule granulate that sieves adds correctives, lubricant, mixing, and compacting is in flakes.
11. preparation method according to claim 10 is characterized in that, to add filler be Icing Sugar, correctives is an Oleum menthae, lubricant is a magnesium stearate.
12. preparation method according to claim 11 is characterized in that, the Icing Sugar weight portion that is added is that 700～1300 parts, Oleum menthae weight portion are that 6～10 parts, magnesium stearate weight portion are 12～30 parts.
13. preparation method according to claim 12 is characterized in that, to add the Icing Sugar weight portion be that 1000 parts, Oleum menthae weight portion are that 7.68 parts, magnesium stearate weight portion are 15 parts.
14. preparation method according to claim 10 is characterized in that, among the step a, the extraction process of terminalia flesh is: add the water of 5～15 times of amounts, soaked 0.5～2 hour, boiled 0.5～2 hour, extract 1～5 time.
15. preparation method according to claim 14 is characterized in that, the preferred extraction process of terminalia flesh is: add the water of 12 times of amounts, soaked 0.5 hour, boiled 0.5 hour, leach extracting solution; Medicinal residues extract twice again, add 10 times of water gagings at every turn, boil 0.5 hour, and merge extractive liquid, is condensed into thick paste.
16. preparation method according to claim 10, it is characterized in that, among the step b: the Borneolum Syntheticum beta-cyclodextrin inclusion compound, press following weight portion proportioning: pure water: beta-schardinger dextrin-: Borneolum Syntheticum=60～95: 5～7.5: 1, get pure water, beta-schardinger dextrin-is put in the container, be heated to 55～65 ℃ and stir and to make dissolving fully, under agitation add Borneolum Syntheticum alcoholic solution (95% ethanol: Borneolum Syntheticum=1～3: 1) fast, stirred 1～3 hour, and left standstill and made to room temperature sucking filtration in 2～4 hours, filtering residue washs 2 times with 95% ethanol is an amount of, drain filtering residue, 50 ℃ of dryings 3～5 hours were pulverized 120 mesh sieves.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101623391B (en) * | 2009-08-11 | 2012-06-06 | 朱林 | Medicine for treating acute and chronic tonsillitis and preparation method thereof |
| CN104435373A (en) * | 2014-10-29 | 2015-03-25 | 广东新峰药业股份有限公司 | Preparation method of Houjiling oral solution |
| CN110946929A (en) * | 2019-12-31 | 2020-04-03 | 广东罗浮山国药股份有限公司 | Application of Houjiling preparation in preparing medicament for treating furunculosis |
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2007
- 2007-01-05 CN CNA2007100262080A patent/CN100998696A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101623391B (en) * | 2009-08-11 | 2012-06-06 | 朱林 | Medicine for treating acute and chronic tonsillitis and preparation method thereof |
| CN104435373A (en) * | 2014-10-29 | 2015-03-25 | 广东新峰药业股份有限公司 | Preparation method of Houjiling oral solution |
| CN110946929A (en) * | 2019-12-31 | 2020-04-03 | 广东罗浮山国药股份有限公司 | Application of Houjiling preparation in preparing medicament for treating furunculosis |
| CN110946929B (en) * | 2019-12-31 | 2023-04-07 | 广东罗浮山国药股份有限公司 | Application of Houjiling preparation in preparing medicament for treating furunculosis |
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