CN100490854C

CN100490854C - Chinese-western medicine composition containing licorzinci

Info

Publication number: CN100490854C
Application number: CNB2007100033984A
Authority: CN
Inventors: 华丽特; 李帮发; 王延泽; 陈炜
Original assignee: Individual
Current assignee: Individual
Priority date: 2007-02-07
Filing date: 2007-02-07
Publication date: 2009-05-27
Anticipated expiration: 2027-02-07
Also published as: CN101007103A

Abstract

The present invention discloses a synergic medicinal composition containing zinc methacrylate and Chinese medicinal extracts, and the use of the composition in preparing medicament for the treatment of acne.

Description

A kind of Chinese and western medicinal composition that contains zinc glycyrrhizate

The present invention relates to a kind of Chinese and western medicinal composition for the treatment of acne.It belongs to field of medicaments.

At present, be used for treating the medicine of acne clinically, Western medicine mainly contains: Ascorbyl B6 paste or erythromycin ointment.Though these medicines are embrocated in the affected part. can solve partial and problem for the moment, curative effect can not be lasting.Its reason just is not solve the basic reason that acne takes place.Theory according to the traditional Chinese medical science: various macules, treat skin ulcer and amass in interior many being accumulate by evil poison, the smooth or wet impatency of pathogenic wind-warm of QI-blood circulation forms in the corrupt blood in skin.Therefore when this class disease of treatment, work as and consider heat-clearing and toxic substances removing, removing heat from blood blood stasis expelling, dispeiling pathogenic wind and removing dampness.Start with from solving the cause of disease that produces acne, reach the purpose of treatment acne.But administration time is long, and onset is slow, and the patient is difficult to long-time medication.

The object of the invention is to provide a kind of Chinese and western medicinal composition of the treatment acne that can address the above problem, and can better treat acne.Chinese medicine used in this application is disclosed Chinese medicine extract among the CN 1071841.

The objective of the invention is to realize by the following method.

A kind of Chinese medicine and western medicine extract, calculating 1:73 by weight by zinc glycyrrhizate and Chinese medicine extract forms, wherein Chinese medicine extract prepares by the following method: Radix Et Rhizoma Rhei 10g, Radix Angelicae Sinensis 15g, Flos Sophorae 15g, Fructus Forsythiae 15g, Radix Achyranthis Bidentatae 15g, Radix Clematidis 15g, Radix Rehmanniae 15g, Flos Lonicerae 15g, Cacumen Platycladi 15g, Radix Sanguisorbae 15g, Radix Paeoniae Rubra 15g, Rhizoma Atractylodis 15g are cleaned, decoct with water twice, each 2 hours, collecting decoction, filter, filtrate decompression is concentrated into the clear paste of relative density 1.15-1.25 (50 ℃ of heat are surveyed), put cold, add ethanol and make and contain alcohol amount and reach 65-75%, stir.Left standstill 24 hours, extraction supernatant, decompression recycling ethanol extremely do not have the alcohol flavor, get thick paste, with thick paste 70-80 ℃ bake drying, get Chinese medicine extract.

Wherein Chinese medicine extract adopts above-mentioned preparation and process, can extract the effective ingredient in the raw material and improve yield, thereby reduce dosage, reduces the cost of this medicine, and this effective elements of the medicine content is improved.This extract has the effect that heat reliving and toxin-eliminating, removing heat from blood blood stasis expelling, dispeiling pathogenic wind and removing dampness and detumescence are only caught.By conditioning, eliminate the cause of disease that produces acne, reach the purpose of treatment acne.And metronidazole has the synthetic effect of the Testosterone of inhibition.Metronidazole and described Chinese medicine extract are used in combination, produce synergism, significantly improve the remedy of acne effect.

To further specify below by following examples:

Embodiment 1: the best preparation and the production technology of Chinese medicine extract.

Radix Et Rhizoma Rhei 10g Radix Angelicae Sinensis 15g Flos Sophorae 15g

Fructus Forsythiae 15g Radix Achyranthis Bidentatae 15g Radix Clematidis 15g

Radix Rehmanniae 15g Flos Lonicerae 15g Cacumen Platycladi 15g

Radix Sanguisorbae 15g Radix Paeoniae Rubra 15g Rhizoma Atractylodis 15g

Above-mentioned raw materials is cleaned, decocted with water twice, each 2 hours, collecting decoction filtered.Filtrate subtracts the village and is concentrated into the clear paste that relative density is 1.20 (50 ℃ of heat are surveyed), puts cold.Add ethanol and make and contain alcohol amount and reach 70%, whisk evenly.Left standstill 24 hours, the extraction supernatant, decompression recycling ethanol gets thick paste to there not being the alcohol flavor.With 80 ℃ of bake dryings of thick paste, get Chinese medicine extract.

Experimental example 2: the pharmacodynamic study of compositions.

Extracorporeal bacteria inhibitor test:

Use the Chinese and western medicinal composition of aforementioned preparation, by China Microbial Culture Preservation Commission medical mycology center on behalf of carrying out extracorporeal bacteria inhibitor test.Check that by bacterium base method three kinds of the Prprionbacerium acnes counts (NO.P.37), the P.acnes ATCC 6919 that are provided by kind university in the Britain and P.aches Su 969 U.S.A are provided bacterial strain uses therefor.Gained is the result point out: present composition 1.0mg is above to have antibacterial action to three strain bacterium.

Experimental example 2: clinical verification

Illustrate:

1. clinical verification material therefor and method:

(1) medicine: the Pharmaceutical composition that uses aforementioned formula and production technology to manufacture

(2) observational technique: select homeliness type acne patient by the diagnosis of " clinical dermatology " required standard.Every day 3 times.Each 0.6g, serveing on for 4 weeks is a course of treatment.Advise the experimenter weekly further consultation once, observed and recorded skin lesion situation of change and and relevant symptom, the Signs of taking medicine.

(3) curative effect determinate standard:

Clinical cure: skin fully and disappear.No New Development skin lesion;

Produce effects: 70% above skin lesion disappears.No New Development skin lesion;

Effectively: 50% left and right sides skin lesion disappears.No New Development skin lesion;

Invalid: period in a medicine only has a small amount of skin lesion to disappear, and the New Development skin lesion is arranged.

2. side effect: all experimenters then ask and apparent side effect all do not occur taking medicine.

Claims

1 one kinds of compositionss for the treatment of acne, it is calculated 1:73 by weight by zinc glycyrrhizate and Chinese medicine extract and forms, wherein Chinese medicine extract prepares by the following method: with Radix Et Rhizoma Rhei 10g, Radix Angelicae Sinensis 15g, Flos Sophorae 15g, Fructus Forsythiae 15g, Radix Achyranthis Bidentatae 15g, Radix Clematidis 15g, Radix Rehmanniae 15g, Flos Lonicerae 15g, Cacumen Platycladi 15g, Radix Sanguisorbae 15g, Radix Paeoniae Rubra 15g, Rhizoma Atractylodis 15g cleans, decoct with water twice, each 2 hours, collecting decoction, filter, relative density was 1.20 clear paste when filtrate decompression was concentrated into 50 ℃ of heat surveys, put coldly, add ethanol and make and contain alcohol amount and reach 70%, stir, left standstill 24 hours, the extraction supernatant, decompression recycling ethanol gets thick paste to there not being the alcohol flavor, with thick paste 70-80 ℃ bake drying, get Chinese medicine extract.

2 purposes of compositions in the medicine of preparation treatment acne according to claim 1.