CN106491414A - A kind of collutory without preservative - Google Patents
A kind of collutory without preservative Download PDFInfo
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- CN106491414A CN106491414A CN201610925011.XA CN201610925011A CN106491414A CN 106491414 A CN106491414 A CN 106491414A CN 201610925011 A CN201610925011 A CN 201610925011A CN 106491414 A CN106491414 A CN 106491414A
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- Prior art keywords
- collutory
- agent
- preservative
- preservative according
- acid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/20—Halogens; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/20—Halogens; Compounds thereof
- A61K8/21—Fluorides; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/30—Characterized by the absence of a particular group of ingredients
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
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- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Cosmetics (AREA)
Abstract
The present invention relates to a kind of collutory without preservative, in the mouthwash formula, each raw materials by weight is composed of the following components：Electrolyte 10%～80%, surfactant 0%～10%, emulsifying agent 0.01%～10%, wetting agent 0.01%～50%, desensitizer 0%～20%, sweeting agent 0.01%～15%, anti-caries agent 0%～1%, essence 0.01%～3%, pigment 0%～3%, pH adjusting agent 0.01%～0.5%, functional components 0%～60%, balance of water.The present invention provides a kind of collutory without preservative and with natural disinfection, antiinflammatory, implication of dispelling effect.
Description
Technical field
The present invention relates to a kind of collutory without preservative, belongs to cosmetics of everyday use technical field.
Background technology
Under conditions of high concentration electrolyte is present, the osmotic pressure of the intracellular protein solution of microorganism and antibacterial is far little
In the osmotic pressure of extracellular electrolyte, now, the intracellular hydrone of microorganism and antibacterial can then pass through cell membrane from infiltration
The little side of pressure penetrates into the big side of osmotic pressure, that is, penetrates into outside cell membrane from cell membrane, so that cell dehydration
Lethal, so as to reach antiseptical purpose.Our common Sal meat curings are exactly that the sodium chloride that make use of high concentration can press down
The effect of antibacterial processed.
With the improvement of people's living standards, to personal cleanliness and the requirement more and more higher of nursing, and oral cavity is used as human body
Gate, the quality of life of people will be had a strong impact in the event of the disease such as hemodia, dental caries, periodontitis, therefore people couple
The safety of oral cavity cleaning and nursing is especially paid close attention to, and increasing people can also use collutory after mouth has been gargled with toothpaste, but
Currently preservative is all added in almost all of collutory.The effect of preservative is to prevent growing for microorganism, reasonably prolongs
The storage life of long products, it is ensured that product will not go bad because of germ contamination during use.A lot of battalion in mouthwash formula
Form point, probably belong to natural organic substance such as aminoacid, protein, saccharide, vitamin etc., none is not antibacterial, micro- life
The excellent environment that thing grows, so in this kind of mouthwash formula, the addition of preservative also must increase therewith.But preservative
Why antibacterial can be killed, be because that preservative can occur chemical reaction with some of microorganism, bacterial cell composition, so as to
Make microorganism and bacterial cell death.Numerous it is demonstrated experimentally that more or less there are zest, or even some to human body in preservative
There are carcinogenesis also, if human body is entered by oral cavity, directly absorbed by the body, its harm will be bigger.
The electrolyte of high concentration is added in collutory, can effectively prevent growing for microorganism and antibacterial, so as to no longer
Need to add preservative, completely eliminate the negative effect brought by preservative.Meanwhile, these electrolyte can also suppress in oral cavity
Antibacterial grow, for auxiliary treatment stomatitis, pharyngolaryngitis, dispel implication etc. and have preferable effect, recommend with doctor
The light salt brine method of gargling have identical effect.
Content of the invention
It is an object of the present invention to provide a kind of collutory without preservative.
Technical scheme：In a kind of mouthwash formula without preservative, by weight percentage by following components
Composition：
Electrolyte 10%～80%,
Surfactant 0%～10%,
Emulsifying agent 0.01%～10%,
Wetting agent 0.01%～50%,
Desensitizer 0%～20%,
Sweeting agent 0.01%～15%,
Anti-caries agent 0%～1%,
Essence 0.01%～3%,
Pigment 0%～3%,
PH adjusting agent 0.01%～0.5%,
Functional components 0%～60%,
Balance of water.
Electrolyte of the present invention is in ionic compound soluble in water.
Further, described surfactant is by anion surfactant, cationic surfactant and nonionic
One or more composition in surfactant.
Further, the emulsifying agent is O/W type emulsifying agents.
Further, the wetting agent includes glycerol, Propylene Glycol, butanediol, pentanediol, Sorbitol, xylitol, Tremella
Hyaluronic acid, hyaluronic acid, trehalose, ceramide, Polyethylene Glycol, polyglycereol, polyamino acid, carbamide, sodium lactate, pyrrolidine
One or more in keto carboxylic acid.
Further, the desensitizer by potassium salt, pink salt, strontium salt, zinc salt, oxalic acid, arginine, pyrophosphate, Calcium Carbonate,
One or more composition in synthetic resin.
Further, the sweeting agent is made up of one or more in saccharin sodium, sweetener, acesulfame potassium, xylitol.
Further, the anti-caries agent is fluorochemical.
Further, described pH adjusting agent be citric acid, citrate, lactic acid, sodium lactate, hydrochloric acid, disodium hydrogen phosphate,
One or more in the aqueous solution of sodium dihydrogen phosphate, sodium hydroxide, potassium hydroxide or triethanolamine.
Further, the functional components are killed comprising plant extract, vitamin and its derivant, menthol, oral cavity
One or more composition in microbial inoculum.
Beneficial effects of the present invention：Preservative be instead of with the electrolyte of high concentration, it is therefore prevented that using with the addition of preservative
The negative effect to health that brought of collutory, simultaneously for auxiliary treatment stomatitis, pharyngolaryngitis, dispel implication
Deng there is preferable effect.
Specific experiment mode
Further detailed description, but embodiments of the present invention not limited to this are done to the present invention in conjunction with the embodiments.
Embodiment 1：
A kind of fresh breath collutory without preservative, composed of the following components：
Sodium chloride 24%,
Polyoxyethylene hydrogenated Oleum Ricini 2%,
Glycerol 10%,
Potassium nitrate 6%,
Saccharin sodium 1%,
Sodium fluoride 0.02%,
Essence 0.2%,
Pigment 0.02%,
PH adjusting agent 0.12%,
Menthol 0.3%,
Balance of water.
Embodiment 2：
A kind of antiallergic collutory without preservative, composed of the following components：
Sodium chloride 24%,
Polyoxyethylene hydrogenated Oleum Ricini 2%,
Glycerol 7%,
Potassium nitrate 8%,
Strontium chloride 4%,
Zinc citrate 2%,
Saccharin sodium 1%,
Essence 0.2%,
Pigment 0.02%,
PH adjusting agent 0.1%,
Balance of water.
Embodiment 3：
A kind of herbal mouthwash without preservative, composed of the following components：
Sodium chloride 24%,
Polysorbate -20 3%,
Glycerol 8%,
Sorbose 6%,
Essence 0.2%,
Pigment 0.03%,
PH adjusting agent 0.1%,
Folium Menthae extract 2%,
Green tea extract 1%,
Grapefruit abstract 1%,
Balance of water.
In order to verify the preservative efficacy of high concentration electrolyte, we adopt American Pharmacopeia USP32<51>To embodiment 1,2 and
3 have carried out antimicrobial preservation efficacy test, and acquired results are as shown in table 1.
Table 1
American Pharmacopeia USP32<51>Judgment criteria be：1）Total number of bacteria from the bacterial population log reduction of initial to 14 days not
2.0 can be less than, and from 14 days to 28 days, bacterial population can not increase；2）Mycete is with yeast sum from initial by 14 days and 28
My god, mycete can not increase with yeast.
According to American Pharmacopeia USP32<51>Judgment criteria, the experimental result in table 1 confirms the electrolyte of high concentration
Can effectively kill and suppress all kinds of antibacterials, can be used to substitute the preservative in collutory.
Claims (10)
1. a kind of collutory without preservative, it is characterised in that composed of the following components by weight percentage：
Electrolyte 10%～80%,
Surfactant 0%～10%,
Emulsifying agent 0.01%～10%,
Wetting agent 0.01%～50%,
Desensitizer 0%～20%,
Sweeting agent 0.01%～15%,
Anti-caries agent 0%～1%,
Essence 0.01%～3%,
Pigment 0%～3%,
PH adjusting agent 0.01%～0.5%,
Functional components 0%～60%,
Balance of water.
2. a kind of collutory without preservative according to claim 1, it is characterised in that the electrolyte is for being soluble in
In the ionic compound of water.
3. a kind of collutory without preservative according to claim 1, it is characterised in that the surfactant is by the moon
One or more composition in ionic surface active agent, cationic surfactant and nonionic surfactant.
4. a kind of collutory without preservative according to claim 1, it is characterised in that the emulsifying agent is O/W types
Emulsifying agent.
5. a kind of collutory without preservative according to claim 1, it is characterised in that the wetting agent is comprising sweet
Oil, Propylene Glycol, butanediol, pentanediol, Sorbitol, xylitol, Tremella hyaluronic acid, hyaluronic acid, trehalose, neural acyl
Amine, Polyethylene Glycol, polyglycereol, polyamino acid, carbamide, sodium lactate, one or more in 2-pyrrolidone-5-carboxylic acid.
6. a kind of collutory without preservative according to claim 1, it is characterised in that the desensitizer by potassium salt,
One or more composition in pink salt, strontium salt, zinc salt, oxalic acid, aminoacid, pyrophosphate, Calcium Carbonate, synthetic resin.
7. a kind of collutory without preservative according to claim 1, it is characterised in that the sweeting agent is by saccharin
One or more composition in sodium, sweetener, acesulfame potassium, xylitol.
8. a kind of collutory without preservative according to claim 1, it is characterised in that the anti-caries agent is fluorine-containing
Compound.
9. a kind of collutory without preservative according to claim 1, it is characterised in that described pH adjusting agent is lemon
Lemon acid, citrate, lactic acid, sodium lactate, hydrochloric acid, disodium hydrogen phosphate, sodium dihydrogen phosphate, sodium hydroxide, potassium hydroxide or three second
One or more in the aqueous solution of hydramine.
10. a kind of collutory without preservative according to claim 1, it is characterised in that the functional components bag
Containing one or more composition in plant extract, vitamin and its derivant, menthol, sterilizing oral agent.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610925011.XA CN106491414A (en) | 2016-10-30 | 2016-10-30 | A kind of collutory without preservative |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610925011.XA CN106491414A (en) | 2016-10-30 | 2016-10-30 | A kind of collutory without preservative |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106491414A true CN106491414A (en) | 2017-03-15 |
Family
ID=58318570
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610925011.XA Pending CN106491414A (en) | 2016-10-30 | 2016-10-30 | A kind of collutory without preservative |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106491414A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110974724A (en) * | 2019-12-30 | 2020-04-10 | 重庆登康口腔护理用品股份有限公司 | Composition containing hyaluronic acid and preparation method and application thereof |
| CN111888303A (en) * | 2020-09-15 | 2020-11-06 | 福建医科大学 | Mouthwash for treating chronic pharyngitis and preparation method thereof |
Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1533761A (en) * | 2003-03-28 | 2004-10-06 | 政 徐 | Salt poris cocos saline taste toothpaste |
| CN1899261A (en) * | 2006-07-26 | 2007-01-24 | 广州立白企业集团有限公司 | Composition and its use in oral nursing |
| CN101011327A (en) * | 2006-12-14 | 2007-08-08 | 成都死海盐疗健康馆服务有限公司 | Mineral salt toothpaste |
| CN101627965A (en) * | 2009-07-21 | 2010-01-20 | 清华大学 | Multifunctional pure natural mouthwash and preparation method thereof |
| CN103249391A (en) * | 2010-12-07 | 2013-08-14 | 荷兰联合利华有限公司 | An antimicrobial microemulsion mouthwash composition |
| CN103263375A (en) * | 2013-05-30 | 2013-08-28 | 云南七丹药业股份有限公司 | Mouthrinse containing extract and preparation method of mouthrinse |
| CN104510664A (en) * | 2013-12-21 | 2015-04-15 | 莫治玲 | Traditional Chinese medicinal mouthwash for inflammation preventing and pain easing |
| CN105412345A (en) * | 2014-09-19 | 2016-03-23 | 王永妍 | Traditional Chinese medicine mouth wash for treating mouth ulcers |
-
2016
- 2016-10-30 CN CN201610925011.XA patent/CN106491414A/en active Pending
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1533761A (en) * | 2003-03-28 | 2004-10-06 | 政 徐 | Salt poris cocos saline taste toothpaste |
| CN1899261A (en) * | 2006-07-26 | 2007-01-24 | 广州立白企业集团有限公司 | Composition and its use in oral nursing |
| CN101011327A (en) * | 2006-12-14 | 2007-08-08 | 成都死海盐疗健康馆服务有限公司 | Mineral salt toothpaste |
| CN101627965A (en) * | 2009-07-21 | 2010-01-20 | 清华大学 | Multifunctional pure natural mouthwash and preparation method thereof |
| CN103249391A (en) * | 2010-12-07 | 2013-08-14 | 荷兰联合利华有限公司 | An antimicrobial microemulsion mouthwash composition |
| CN103263375A (en) * | 2013-05-30 | 2013-08-28 | 云南七丹药业股份有限公司 | Mouthrinse containing extract and preparation method of mouthrinse |
| CN104510664A (en) * | 2013-12-21 | 2015-04-15 | 莫治玲 | Traditional Chinese medicinal mouthwash for inflammation preventing and pain easing |
| CN105412345A (en) * | 2014-09-19 | 2016-03-23 | 王永妍 | Traditional Chinese medicine mouth wash for treating mouth ulcers |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110974724A (en) * | 2019-12-30 | 2020-04-10 | 重庆登康口腔护理用品股份有限公司 | Composition containing hyaluronic acid and preparation method and application thereof |
| CN111888303A (en) * | 2020-09-15 | 2020-11-06 | 福建医科大学 | Mouthwash for treating chronic pharyngitis and preparation method thereof |
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| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| CB03 | Change of inventor or designer information | ||
| CB03 | Change of inventor or designer information |
Inventor after: Wu Huabing Inventor after: Liang Yao Inventor after: Zhan Kai Inventor after: Zhao Yingxiang Inventor after: Yu Qi Inventor before: Dai Ying |
|
| TA01 | Transfer of patent application right | ||
| TA01 | Transfer of patent application right |
Effective date of registration: 20180224 Address after: 410000 Changsha City, Hunan province high tech Development Zone, Yuelu Avenue West, No. 588, Changsha core city science and Technology Park, building 6, building 6 Applicant after: China Polytron Technologies Inc Address before: 410000 Hunan, Yuelu District orange Chau Street Xiaoxiang Road, the middle part of the University of science and Technology Park, Pegasus Village Building Applicant before: Changsha Huachen Biotechnology Co., Ltd. |
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| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| TA01 | Transfer of patent application right | ||
| TA01 | Transfer of patent application right |
Effective date of registration: 20180720 Address after: 410000 Xiaoxiang Road, Tianma Road, Tianma Road, Hunan, Changsha, Yuelu District, B4088 Applicant after: Changsha Huachen Biotechnology Co., Ltd. Address before: 410000 6, 6 Changsha road core technology park, 588 Yuelu Avenue West, Changsha high tech Development Zone, Hunan. Applicant before: China Polytron Technologies Inc |
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| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20170315 |