CN108042383A - A kind of anti-inflammatory, antibacterial Domiphen bromide mouthwash and preparation method thereof - Google Patents
A kind of anti-inflammatory, antibacterial Domiphen bromide mouthwash and preparation method thereof Download PDFInfo
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- CN108042383A CN108042383A CN201810137158.1A CN201810137158A CN108042383A CN 108042383 A CN108042383 A CN 108042383A CN 201810137158 A CN201810137158 A CN 201810137158A CN 108042383 A CN108042383 A CN 108042383A
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- mouthwash
- acid
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- inflammatory
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/41—Amines
- A61K8/416—Quaternary ammonium compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
Abstract
The invention discloses a kind of anti-inflammatory, antibacterial Domiphen bromide mouthwash, compositions：Sweetener 0.003% ~ 0.1%；Acid 0.01%~0.3%；Moisturizer 2%~15%；Essence 0.05%~0.5%；Solubilizer 0.5%~2.5%；Coolant agent 0.02%~0.05%；Bacteriostatic agent 0.02% ~ 0.05%；Preservative 0.1%~0.4%；Deionized water surplus；The PH of the mouthrinse product is 3~5.Method includes：Sweetener and acid are added in into stirring and dissolving in water deionization, then moisturizer is added in aqueous solution, is stirred evenly；Solubilizer, essence and coolant agent are stirred to form uniform oily solution；In the state of stirring, oily solution is slowly added into water-soluble clarified solution, is uniformly mixed；Bacteriostatic agent, preservative are added in aqueous solution, are mixed evenly；Stop stirring, when standing 24 is small, filter, the mouthwash finished product that PH is 3~5 is obtained after aseptic process.The present invention can to oral cleaning, dispel implication and bacteria resistance function while, also have to throat anti-inflammatory, it is antibacterial, repair and other effects.
Description
Technical field
The present invention relates to oral care product technical field more particularly to a kind of anti-inflammatory, antibacterial Domiphen bromide mouthwash and
Its preparation method.
Background technology
With the improvement of living standards, people increasingly improve the attention rate of oral health, common oral care is also no longer
It is confined to brush teeth twice sooner or later, the species and form demand to oral care product tend to diversification and fashion-orientation.Mouthwash is
Through into the necessity in for people's lives, it is easy to use, and effect can be equal to toothpaste, and use is more convenient than toothpaste, but mesh
The mouthwash of preceding market often act on it is single, and for a long time use protective effect is not had to tooth.It is also, existing at present
The acid-base value of mouthwash be generally neutrality, main function include antibacterial bacteriostatic, improve oral peculiar smell, anti-inflammatory, cleaning oral cavity it is thin
Bacterium and tartar etc., species include Chinese medicine draft class, natural plant extracts class and drug ingedient composite class.
105769718 A of CN disclose it is a kind of for cleaning the Chinese medicine mouth wash in oral cavity, in the Chinese medicine mouth wash be by with
The Chinese medicine material composition of lower weight：40~60 parts of kuh-seng, 80~110 parts of Radix Isatidis, 20~40 parts of honeysuckle, rhizoma atractylodis 30
~50 parts, 30~40 parts of Verbena officinalis, 30~40 parts of Schisandra chinensis, 15~25 parts of peppermint.This Chinese medicine mouth wash has clearing heat and cooling blood solution
It the benefits of poison, antibacterial anti-inflammatory analgesia, is cleaned suitable for mouth cavity daily, while suitable for that can lack of proper care because of bacterium, oral cavity, throat, tonsillotome
Positions is waited by bacterium, virogenetic infection and swelling and aching of gum, canker sore, halitosis etc. oral cavity can be made thoroughly fragrant, clean refreshing, easypro
It fits, naturally, can long-time service.
104688629 A of CN disclose a kind of anti-oral cavity and burst scorching mouthwash, are made of the component of volumes below percentage
：It is lemon juice 0.5~1%, Tomato juice 1~5%, vitamin C 0.1~0.5%, vinegar 8~15%, Chinese medicine extract 5~14%, remaining
It measures as deionized water；Wherein described Chinese medicine extract is made of the raw material of following parts by weight：15~30 parts of the leaf of bamboo, oldenlandia
1~10 part of grass, 5~12 parts of radix ampelopsis, 3~10 parts of smalt, 8~17 parts of the sterculia seed, 5~15 parts of rush, rose 10~20
Part, 1~8 part of garlic, 5~12 parts of cottonrose hibiscus leaf, 7~15 parts of mulberry leaf.Mouthwash produced by the present invention has unique antibacterial
Anti-inflammatory, analgesic promoting muscle growth functions, can effectively inhibit the formation of oral inflammation, maintain Oral Bacteria state balance, moment cleaning oral cavity, prevention
Effect is good, and environmentally protective, low production cost.
104887569 A of CN disclose a kind of mouthwash, belong to daily chemical product technical field.The present invention is by following heavy
The raw material of amount number is prepared：20 parts~25 parts of Radix zanthoxyli, 10 parts~12 parts of sanchi leaf, 10 parts~12 parts of Siraitia grosvenorii, lotus
15 parts~20 parts, 5 parts~8 parts of green tea, 0.5 part~1 part of vine polyphenol, 1 part~5 parts of sodium chloride and deionized water 100
Part.The present invention from each middle medicinal herbs of natural material by extracting active ingredient, and combination collocation uses, so that obtained gargle
Water not only has cleaning, mothproof, hemostasis, whitening effect, due also to what it used is natural plant material, therefore is free of
The chemical substances such as triclosan or metronidazole, Tinidazole, hydrogen peroxide, iodine solution, alcohol can act on common oral care use, with
And since its is sweet, faint scent, so as to be easier to be accepted by people.
Various mouthwashes described in above-mentioned patent, although play the antibacterial anti-inflammatory to tooth and oral cavity, cleaning oral cavity and
Tooth and the effect for being effectively improved oral peculiar smell, but it is substantially neutrality, cleans the effect of tartar and oral foreign body
Be not obvious, and can not to throat carry out anti-inflammatory, it is antibacterial, repair therefore, how effectively, quickly, thoroughly realize tooth
Adhesion and staining removing, while throat is carried out anti-inflammatory, it is antibacterial, repair, be to restrict current mouth cavity daily shield
A problem of industry is managed, and the mouthwash of pure Chinese medicine ingredient primarily serves the effect of reparation, anti-inflammatory, and act on outside
Chinese medicine effect it is often slow, be not obvious for the effect of bacteriostasis antibiosis.
The content of the invention
In view of the deficienciess of the prior art, the technical problem to be solved by the invention is to provide it is a kind of to oral cleaning,
While dispelling implication and bacteria resistance function, also there are the anti-inflammatory of anti-inflammatory, antibacterial, reparation and other effects, antibacterial Domiphen bromide to gargle to throat
Saliva and preparation method thereof.
In order to solve the above technical problems, the technical solution used in the present invention is：A kind of anti-inflammatory, antibacterial Domiphen bromide are gargled
Water, by forming following weight percentage components：
Sweetener 0.003% ~ 0.1%；
Acid 0.01%~0.3%；
Moisturizer 2%~15%；
Essence 0.05%~0.5%；
Solubilizer 0.5%~2.5%；
Coolant agent 0.02%~0.05%；
Bacteriostatic agent 0.02% ~ 0.05%；
Preservative 0.1%~0.4%；
Deionized water surplus；
The PH of the mouthrinse product is 3~5.
Above-mentioned anti-inflammatory, antibacterial Domiphen bromide mouthwash, by forming following weight percentage components：
Sweetener 0.05%；
Acid 0.15%；
Moisturizer 8%；
Essence 0.3%；
Solubilizer 1.5%；
Coolant agent 0.035%；
Bacteriostatic agent 0.035%；
Preservative 0.25%；
Deionized water surplus；
The PH of the mouthrinse product is 4.
Above-mentioned anti-inflammatory, antibacterial Domiphen bromide mouthwash, the sweetener for saccharin sodium, D-sorbite, Sucralose, Ah
One or more of this Ba Tian, honey element, acid are citric acid or malic acid, and moisturizer is glycerine, sorbierite, propylene glycol
One or more of, essence is the fruit such as green tea, spearmint, honey peach perfume or the fragrance of a flower, and solubilizer is polysorbas20 or PEG-40
Rilanit special, coolant agent are menthol, and preservative is one or more of potassium sorbate, sodium benzoate, methyl hydroxybenzoate, is pressed down
Microbial inoculum is Domiphen bromide.
It is a kind of to prepare anti-inflammatory, the method for antibacterial Domiphen bromide mouthwash, include the following steps：
（1）, sweetener and acid are added in stirring and dissolving in water deionization, then moisturizer is added in aqueous solution, stirring is equal
It is even and form finely dispersed water-soluble clarified solution；
（2）, solubilizer, essence and coolant agent stirred to form uniform oily solution；
（3）, in the state of stirring, oily solution is slowly added into water-soluble clarified solution, be uniformly mixed；
（4）, by bacteriostatic agent, preservative add in step（3）In the aqueous solution of acquisition, it is mixed evenly；
（5）, stop stirring, stand 24 it is small when, filtering, after aseptic process PH be 3~5 mouthwash finished product.
Above-mentioned anti-inflammatory, the preparation method of antibacterial Domiphen bromide mouthwash, the sweetener is saccharin sodium, D-sorbite,
One or more of Sucralose, Aspartame, honey element, acid are citric acid or malic acid, and moisturizer is glycerine, mountain
One or more of pears alcohol, propylene glycol, essence are tween for the fruit such as green tea, spearmint, honey peach perfume or the fragrance of a flower, solubilizer
20 or Cremophor RH40, coolant agent is menthol, and preservative is potassium sorbate, one in sodium benzoate, methyl hydroxybenzoate
Kind is several, and bacteriostatic agent is Domiphen bromide.
The advantages of anti-inflammatory of the present invention, antibacterial Domiphen bromide mouthwash and preparation method thereof is：Domiphen bromide is added, it can be with deep layer
It cleans tartar, inhibit oral bacteria growth, removal implication, tooth-whitening, inhibition dental plaque generation, while to treatment gingivitis, tooth
The oral inflammations such as Zhou Yan, canker sore have effects that certain alleviation, cure.And to oral cleaning, dispel implication and antibacterial
While function, acid environment, it is easier to the adhesion of tooth and staining is made to have clean more thorough effect, it is cool
Taste agent, solubilizer can play throat anti-inflammatory, antibacterial and reparation effect.
Specific embodiment
The present invention is described in further details with reference to specific embodiment；
Embodiment 1：
A kind of anti-inflammatory, antibacterial Domiphen bromide mouthwash, by forming following weight percentage components：Sweetener 0.003%；Tart flavour
Agent 0.01%；Moisturizer 2%；Essence 0.05%；Solubilizer 0.5%；Coolant agent 0.02%；Bacteriostatic agent 0.02%；Preservative 0.1%；It goes
Ion water surplus；The PH of the mouthrinse product is 5.The sweetener is saccharin sodium, D-sorbite, and acid is citric acid,
Moisturizer is glycerine, sorbierite, and essence is the green tea fragrance of a flower, and solubilizer is polysorbas20, and coolant agent is menthol, and preservative is sorb
Sour potassium, sodium benzoate, bacteriostatic agent are Domiphen bromide.
It is a kind of to prepare anti-inflammatory, the method for antibacterial Domiphen bromide mouthwash, include the following steps：
（1）, sweetener and acid are added in stirring and dissolving in water deionization, then moisturizer is added in aqueous solution, stirring is equal
It is even and form finely dispersed water-soluble clarified solution；
（2）, solubilizer, essence and coolant agent stirred to form uniform oily solution；
（3）, in the state of stirring, oily solution is slowly added into water-soluble clarified solution, be uniformly mixed；
（4）, by bacteriostatic agent, preservative add in step（3）In the aqueous solution of acquisition, it is mixed evenly；
（5）, stop stirring, stand 24 it is small when, filtering, after aseptic process PH be 5 mouthwash finished product.
The sweetener is saccharin sodium, D-sorbite, and acid is citric acid, and moisturizer is glycerine, sorbierite, and essence is
The green tea fragrance of a flower, solubilizer are polysorbas20, and coolant agent is menthol, and preservative is potassium sorbate, sodium benzoate, and bacteriostatic agent is degree rice
It is fragrant.
Embodiment 2：
A kind of anti-inflammatory, antibacterial Domiphen bromide mouthwash, by forming following weight percentage components：Sweetener 0.05%；Acid
0.15%；Moisturizer 8%；Essence 0.3%；Solubilizer 1.5%；Coolant agent 0.035%；Bacteriostatic agent 0.035%；Preservative 0.25%；It goes
Ion water surplus；The PH of the mouthrinse product is 4.The sweetener is Sucralose, Aspartame, honey element, acid
For malic acid, moisturizer is sorbierite, propylene glycol, and essence is the spearmint fragrance of a flower, and solubilizer is Cremophor RH40, cool taste
Agent is menthol, and preservative is sodium benzoate, methyl hydroxybenzoate, and bacteriostatic agent is Domiphen bromide.
It is a kind of to prepare anti-inflammatory, the method for antibacterial Domiphen bromide mouthwash, include the following steps：
（1）, sweetener and acid are added in stirring and dissolving in water deionization, then moisturizer is added in aqueous solution, stirring is equal
It is even and form finely dispersed water-soluble clarified solution；
（2）, solubilizer, essence and coolant agent stirred to form uniform oily solution；
（3）, in the state of stirring, oily solution is slowly added into water-soluble clarified solution, be uniformly mixed；
（4）, by bacteriostatic agent, preservative add in step（3）In the aqueous solution of acquisition, it is mixed evenly；
（5）, stop stirring, stand 24 it is small when, filtering, after aseptic process PH be 4 mouthwash finished product.
The sweetener is Sucralose, Aspartame, honey element, and acid is malic acid, and moisturizer is sorbierite, third
Glycol, essence are the spearmint fragrance of a flower, and solubilizer is Cremophor RH40, and coolant agent is menthol, and preservative is benzoic acid
Sodium, methyl hydroxybenzoate, bacteriostatic agent are Domiphen bromide.
Embodiment 3：
A kind of anti-inflammatory, antibacterial Domiphen bromide mouthwash, by forming following weight percentage components：Sweetener 0.1%；Acid
0.3%；Moisturizer 15%；Essence 0.5%；Solubilizer 2.5%；Coolant agent 0.05%；Bacteriostatic agent 0.05%；Preservative 0.4%；Deionization
Water surplus；The PH of the mouthrinse product is 3.Sweetener is saccharin sodium, Aspartame, honey element, and acid is citric acid, is protected
Humectant is glycerine, propylene glycol, and essence is fragrant for honey peach fruit, and solubilizer is polysorbas20, and coolant agent is menthol, and preservative is mountain
Potassium sorbate, methyl hydroxybenzoate, bacteriostatic agent are Domiphen bromide.
It is a kind of to prepare anti-inflammatory, the method for antibacterial Domiphen bromide mouthwash, include the following steps：
（1）, sweetener and acid are added in stirring and dissolving in water deionization, then moisturizer is added in aqueous solution, stirring is equal
It is even and form finely dispersed water-soluble clarified solution；
（2）, solubilizer, essence and coolant agent stirred to form uniform oily solution；
（3）, in the state of stirring, oily solution is slowly added into water-soluble clarified solution, be uniformly mixed；
（4）, by bacteriostatic agent, preservative add in step（3）In the aqueous solution of acquisition, it is mixed evenly；
（5）, stop stirring, stand 24 it is small when, filtering, after aseptic process PH be 3 mouthwash finished product.
Sweetener is saccharin sodium, Aspartame, honey element, and acid is citric acid, and moisturizer is glycerine, propylene glycol, fragrant
Essence is fragrant for honey peach fruit, and solubilizer is polysorbas20, and coolant agent is menthol, and preservative is potassium sorbate, methyl hydroxybenzoate, antibacterial
Agent is Domiphen bromide.
Certainly, it is limitation of the present invention that above description, which is not, and the present invention is also not limited to the example above, the art
Those of ordinary skill, in the essential scope of the present invention, the variations, modifications, additions or substitutions made should all belong to the present invention
Protection domain.
Claims (5)
1. a kind of anti-inflammatory, antibacterial Domiphen bromide mouthwash, which is characterized in that by forming following weight percentage components：
Sweetener 0.003% ~ 0.1%；
Acid 0.01%~0.3%；
Moisturizer 2%~15%；
Essence 0.05%~0.5%；
Solubilizer 0.5%~2.5%；
Coolant agent 0.02%~0.05%；
Bacteriostatic agent 0.02% ~ 0.05%；
Preservative 0.1%~0.4%；
Deionized water surplus；
The PH of the mouthrinse product is 3~5.
2. anti-inflammatory according to claim 1, antibacterial Domiphen bromide mouthwash, it is characterized in that, by following weight percent
Component forms：
Sweetener 0.05%；
Acid 0.15%；
Moisturizer 8%；
Essence 0.3%；
Solubilizer 1.5%；
Coolant agent 0.035%；
Bacteriostatic agent 0.035%；
Preservative 0.25%；
Deionized water surplus；
The PH of the mouthrinse product is 4.
3. anti-inflammatory according to claim 1, antibacterial Domiphen bromide mouthwash, it is characterized in that：The sweetener for saccharin sodium,
One or more of D-sorbite, Sucralose, Aspartame, honey element, acid be citric acid or malic acid, moisturizer
For one or more of glycerine, sorbierite, propylene glycol, essence is the fruit such as green tea, spearmint, honey peach perfume or the fragrance of a flower, is increased
Solvent is polysorbas20 or Cremophor RH40, and coolant agent is menthol, and preservative is potassium sorbate, sodium benzoate, oxybenzene
One or more of methyl esters, bacteriostatic agent are Domiphen bromide.
4. a kind of prepare anti-inflammatory, the method for antibacterial Domiphen bromide mouthwash, which is characterized in that includes the following steps：
（1）, sweetener and acid are added in stirring and dissolving in water deionization, then moisturizer is added in aqueous solution, stirring is equal
It is even and form finely dispersed water-soluble clarified solution；
（2）, solubilizer, essence and coolant agent stirred to form uniform oily solution；
（3）, in the state of stirring, oily solution is slowly added into water-soluble clarified solution, be uniformly mixed；
（4）, by bacteriostatic agent, preservative add in step（3）In the aqueous solution of acquisition, it is mixed evenly；
（5）, stop stirring, stand 24 it is small when, filtering, after aseptic process PH be 3~5 mouthwash finished product.
5. anti-inflammatory according to claim 4, the preparation method of antibacterial Domiphen bromide mouthwash, it is characterized in that：The sweet taste
Agent is one or more of saccharin sodium, D-sorbite, Sucralose, Aspartame, honey element, and acid is citric acid or apple
Tartaric acid, moisturizer are one or more of glycerine, sorbierite, propylene glycol, and essence is the fruit such as green tea, spearmint, honey peach
The fragrant or fragrance of a flower, solubilizer are polysorbas20 or Cremophor RH40, and coolant agent is menthol, and preservative is potassium sorbate, benzene
One or more of sodium formate, methyl hydroxybenzoate, bacteriostatic agent are Domiphen bromide.
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| CN201810137158.1A CN108042383A (en) | 2018-02-10 | 2018-02-10 | A kind of anti-inflammatory, antibacterial Domiphen bromide mouthwash and preparation method thereof |
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| CN201810137158.1A CN108042383A (en) | 2018-02-10 | 2018-02-10 | A kind of anti-inflammatory, antibacterial Domiphen bromide mouthwash and preparation method thereof |
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Cited By (8)
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| CN108685835A (en) * | 2018-08-01 | 2018-10-23 | 金心国际商贸（深圳）有限公司 | A kind of multifunctional gargle |
| WO2020021483A1 (en) * | 2018-07-27 | 2020-01-30 | Grzegorz Kalbarczyk Arkona Laboratorium Farmakologii | Composition for the treatment of oral cavity inflammations |
| CN111265556A (en) * | 2019-11-11 | 2020-06-12 | 五赫兹（厦门）医疗用品有限公司 | Medical oral bacteriostatic composition and preparation method and application thereof |
| CN111728905A (en) * | 2020-06-02 | 2020-10-02 | 福州安得尔卫生技术开发有限公司 | Plant gargle |
| CN112245317A (en) * | 2020-09-07 | 2021-01-22 | 广州雨晓生物制品有限公司 | Mouthwash |
| CN112402278A (en) * | 2020-11-16 | 2021-02-26 | 北京华素制药股份有限公司 | Sodium azulene sulfonate compound gargle and preparation method thereof |
| CN112675261A (en) * | 2021-01-05 | 2021-04-20 | 安徽中医药大学第一附属医院(安徽省中医院) | Traditional Chinese medicine mouth wash capable of diminishing inflammation and promoting fluid production and preparation method thereof |
| CN114886791A (en) * | 2022-05-09 | 2022-08-12 | 广州市白云区大荣精细化工有限公司 | Bubble type sterilization and bacteriostasis mouth wash and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2020021483A1 (en) * | 2018-07-27 | 2020-01-30 | Grzegorz Kalbarczyk Arkona Laboratorium Farmakologii | Composition for the treatment of oral cavity inflammations |
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| CN112402278B (en) * | 2020-11-16 | 2022-09-06 | 北京华素制药股份有限公司 | Sodium azulene sulfonate compound gargle and preparation method thereof |
| CN112675261A (en) * | 2021-01-05 | 2021-04-20 | 安徽中医药大学第一附属医院(安徽省中医院) | Traditional Chinese medicine mouth wash capable of diminishing inflammation and promoting fluid production and preparation method thereof |
| CN114886791A (en) * | 2022-05-09 | 2022-08-12 | 广州市白云区大荣精细化工有限公司 | Bubble type sterilization and bacteriostasis mouth wash and preparation method thereof |
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Application publication date: 20180518 |
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