CN112675261A - Traditional Chinese medicine mouth wash capable of diminishing inflammation and promoting fluid production and preparation method thereof - Google Patents

Abstract

A traditional Chinese medicine mouth wash for diminishing inflammation and promoting the secretion of saliva and a preparation method thereof belong to the technical field of oral care products. The effective components of the traditional Chinese medicine are prepared from 14 traditional Chinese medicine raw materials of dwarf lilyturf tuber, asparagus, dark plum fruit, boat-fruited sterculia seed, grosvenor momordica fruit, coastal glehnia root, dendrobium, cogongrass rhizome, tangerine peel, mint, chrysanthemum, honeysuckle, bletilla and dragon's blood. The traditional Chinese medicine mouthwash for diminishing inflammation and promoting the secretion of saliva is obtained by extracting the traditional Chinese medicine to obtain a traditional Chinese medicine extract, adding citric acid, xylitol and domiphen bromide and uniformly mixing. The compatibility of the prescription is characterized in that: sweet-cold is compatible with pungent-warm, and sweet-cold is the main reason; the evacuation is matched with the clearing, and the clearing is considered; has the effects of clearing away heat and toxic materials, promoting salivation, quenching thirst, relieving inflammation, and inhibiting bacteria. The traditional Chinese medicine mouthwash for diminishing inflammation and promoting the secretion of saliva has the functions of clearing away heat and toxic materials, promoting the secretion of saliva to quench thirst, diminishing inflammation and inhibiting bacteria, has no irritation, does not generate drug resistance, and has no toxic or side effect on a human body. Can effectively inhibit oral bacteria, remove oral odor, has good effects of cleaning and caring oral cavity, and simultaneously prevents occurrence and development of oral diseases.

Description

Traditional Chinese medicine mouth wash capable of diminishing inflammation and promoting fluid production and preparation method thereof

Technical Field

The invention belongs to the technical field of oral care products, and particularly relates to an anti-inflammatory and saliva-promoting traditional Chinese medicine mouthwash and a preparation method thereof.

Background

Oral diseases are one of the major public health problems at present due to their particularly high prevalence and incidence. Oral microorganisms are the leading cause of oral disease. The surface area of the teeth is only 25% of the surface area of the oral cavity, and conventional tooth brushing has been the main means for preventing and treating oral diseases, but is not enough for cleaning. Therefore, the product of the mouthwash is produced at the same time.

Gargling is the most common self-care method, and is generally gargled with clean water or brackish water. Some mouthwashes are combined with certain drugs to make mouth washes, which have the effect of assisting in preventing and controlling oral diseases. Rinsing the mouth can remove food residues in the oral cavity and keep the oral cavity clean. However, some mouthwash products have some adverse effects on human bodies in the using process, for example, the mouthwash taking hydrogen peroxide as the main component can cause demineralization of tooth surfaces and side effects such as black hair and tongue and the like after being used for a long time, and the mouthwash containing chlorhexidine can increase blood pressure after being used twice a day, so that the probability of heart disease and stroke is increased.

At present, most of products on the market can not take the taste and the irritation of the mouthwash into consideration while keeping the sterilizing effect and the breath freshening capability. Most of the mouthwash products in the market have stronger sterilizing effect and breath freshening capability but do not pay attention to the experience of consumers; or the user is seriously paid with attention to the experience and loses due efficacy, and most of the two can not be considered at the same time. Most products in the market contain alcohol, and the alcohol has great harm to oral mucosa, causes xerostomia simultaneously, reduces the comfort of consumers after using the mouthwash. The australian national cancer institute reports that a mouthwash having an alcohol content of 25% or greater is associated with canceration of the mouth, tongue and throat, requiring prolonged residence in the mouth and the tendency of the alcohol to become acetaldehyde when used. If mouth wash is used as well as alcohol, the chance of oral cancer increases. In addition, some mouthwashes contain an alcoholic component that helps break down plaque, but at the same time it may cause dryness in the mouth. The products commonly found on the market contain various chemical additives, with more or less toxic side effects. Most of the common mouthwash products in the market are prepared by mixing various chemical additives, and have more or less harm to human bodies.

Chinese patent application CN 108186441A discloses a hemostatic and antiallergic composite herbal mouthwash and a preparation method thereof, wherein the main components of the mouthwash are a sweetener, an acidity agent, a humectant, essence, an active agent, a solubilizer, a bacteriostatic agent, a preservative and deionized water, and the main propaganda effects of the mouthwash are repairing the oral cavity, removing the oral cavity and stopping bleeding and resisting allergy in one place. However, the components of the mouthwash are low in traditional Chinese medicine component ratio, so that the propaganda effect cannot be effectively achieved, and most of the components of the mouthwash are conventional raw material components of traditional mouthwashes.

Chinese patent application CN 108685835A discloses a multifunctional mouthwash, which mainly comprises water, glycerol, xylitol, grape seed extract, citric acid, malic acid, menthol and saccharin sodium, and also comprises Chinese medicinal components such as gallnut extract, hairyvein agrimony extract, liquorice extract, levant incense, honeysuckle extract and the like. The mouthwash product has the defects of complex preparation process and the like, and partial raw materials are difficult to obtain or process, so that the manufacturing cost of the final product is too high, and the final product is difficult to popularize and apply to the market quickly.

At present, no relevant literature report is found on a traditional Chinese medicine mouthwash product which can realize the function of mouthwash and can also achieve the effects of diminishing inflammation and promoting the secretion of saliva.

Disclosure of Invention

The technical problem to be solved by the invention is to provide the traditional Chinese medicine mouthwash with the functions of clearing away heat and toxic materials, promoting the production of body fluid to quench thirst, diminishing inflammation and inhibiting bacteria, and no irritation; meanwhile, the invention also provides a preparation method of the traditional Chinese medicine mouthwash for diminishing inflammation and promoting the secretion of saliva.

In order to achieve the purpose, the technical scheme adopted by the invention is as follows: a traditional Chinese medicine mouth wash for diminishing inflammation and promoting the secretion of saliva contains traditional Chinese medicine extracts, wherein the traditional Chinese medicine extracts are prepared from the following traditional Chinese medicine raw materials in parts by weight:

as a preferred technical scheme of the anti-inflammation and saliva-promoting traditional Chinese medicine mouthwash, the traditional Chinese medicine extract is prepared from the following traditional Chinese medicine raw materials in parts by weight:

as a further preferable technical scheme of the anti-inflammation and saliva secretion promoting traditional Chinese medicine mouthwash, the traditional Chinese medicine extract is prepared from the following traditional Chinese medicine raw materials in parts by weight:

the traditional Chinese medicine mouthwash for diminishing inflammation and promoting the secretion of saliva is prepared from the following components in parts by weight, based on 100 g:

preferably, the traditional Chinese medicine mouthwash for diminishing inflammation and promoting the secretion of saliva is prepared from the following components in parts by weight, based on 100 g:

the preparation method of the traditional Chinese medicine mouthwash for diminishing inflammation and promoting the secretion of saliva comprises the following steps:

1) preparation of Chinese medicine extract

Decocting radix Ophiopogonis, radix asparagi, mume fructus, semen Scaphii Lychnophori, fructus Siraitiae Grosvenorii, radix Glehniae, herba Dendrobii, lalang grass rhizome, pericarpium Citri Tangerinae, herba Menthae, flos Chrysanthemi, flos Lonicerae, rhizoma Bletillae and sanguis Draxonis with water for three times, the first time with 10 times of water for 1.5 hr, and the second and third times with 8 times of water for 1 hr; mixing extractive solutions, filtering, standing for 48 hr, collecting supernatant, and concentrating under reduced pressure to specific gravity of 1.10;

2) preparation of traditional Chinese medicine mouth wash for diminishing inflammation and promoting fluid production

Adding the traditional Chinese medicine extract, citric acid, xylitol and domiphen bromide into a mixing container, adding part of deionized water, mixing, filtering, adding the rest of deionized water, filling, inspecting, and warehousing.

According to the invention, a plurality of traditional Chinese medicine components which are effective in treating oral diseases are screened out through a large amount of literature investigation, the formula of the mouthwash is determined to be radix ophiopogonis, radix asparagi, dark plum fruit, scaphium scaphigerum, momordica grosvenori, radix glehniae, dendrobe, lalang grass rhizome, dried orange peel, mint, chrysanthemum, honeysuckle, bletilla and dragon's blood, traditional Chinese medicines are extracted to obtain a traditional Chinese medicine extract, citric acid, xylitol and domiphen bromide are added, and the traditional Chinese medicine mouthwash for diminishing inflammation and promoting the secretion of saliva or body fluid is obtained.

The traditional Chinese medicine prescription for diminishing inflammation and promoting the secretion of saliva has the compatibility characteristics that: sweet-cold is compatible with pungent-warm, and sweet-cold is the main reason; the evacuation is matched with the clearing, and the clearing is considered; has the effects of clearing away heat and toxic materials, promoting salivation, quenching thirst, relieving inflammation, and inhibiting bacteria. The prescription comprises the following components:

the honeysuckle flower is sweet in taste and cold in nature, is good at clearing away heat and toxic materials and treating sores, clears and disperses pathogenic factors, can avoid dirt and remove turbidity, and has the characteristics of easily accumulated warm pathogenic factors to become toxic and often accompanied with foul and turbid qi while dispersing and defending exterior pathogenic factors. It is the principal herb for sores and ulcers. The dried orange peel is bitter in taste and cold in nature, and can eliminate dampness and phlegm, relieve asthma and eliminate phlegm; the chrysanthemum is pungent, sweet and cold in nature, and can dispel wind-heat, clear head and eyes and descend lung; the mint is pungent in flavor and cool in nature, is good at dispelling wind heat in upper jiao and inducing sweating, and can clear heat and improve eyesight, detoxify and relieve sore throat, and help monarch drugs to dispel wind heat; the two drugs mutually reinforce, directly go to the upper energizer, are used cooperatively to disperse lung stroke heat and are used as ministerial drugs. The cogongrass rhizome, sweet in taste and cold in nature, has the functions of cooling blood and stopping bleeding, promoting the production of body fluid and quenching thirst as an adjuvant, reduces the fire of inflammation, removes the heat of blood system, and eliminates the heat toxin internally and thoroughly, thereby preventing the ministerial drugs from sweating too much to cause body fluid consumption. The asparagus root and the dwarf lilyturf tuber are matched to nourish yin and promote the production of body fluid, clear away the lung-heat and moisten dryness. Dark plum is sour in flavor, can astringe floating heat and can inhale qi to return to original, so it is indicated for dry mouth due to saliva, flaring up of deficient fire and insufficiency of body fluid. Boat-fruited sterculia seed has the effects of clearing heat, moistening lung, relieving sore throat and detoxifying. Fructus Siraitiae Grosvenorii has effects of relieving sore throat, killing bacteria, and relieving inflammation; bei Sha Shen is sweet and slightly bitter in taste and slightly cold in nature; entering lung and stomach meridians; has the effects of nourishing yin, clearing away lung-heat, benefiting stomach and promoting fluid production. Herba Dendrobii has effects of benefiting stomach, promoting fluid production, nourishing yin and clearing heat. Rhizoma Bletillae has effects of astringing, stopping bleeding, relieving swelling and promoting granulation. Sanguis Draxonis has effects of promoting blood circulation, relieving pain, removing blood stasis, stopping bleeding, promoting granulation, and healing sore.

The main component of the anti-inflammatory and salivation promoting Chinese medicinal mouthwash product is a Chinese medicinal extract, has the effects of clearing away heat and toxic materials, promoting salivation to quench thirst, diminishing inflammation and inhibiting bacteria, has no irritation, does not generate medicament resistance, and has no toxic or side effect on a human body. Can effectively inhibit oral bacteria, remove oral odor, has good effects of cleaning and caring oral cavity, and simultaneously prevents occurrence and development of oral diseases. More importantly, the basic thinking of the traditional Chinese medicine is used for the compatibility application of the natural herbs, and the traditional Chinese medicine has the advantages of rich and easily obtained raw materials, low cost, simple preparation method and suitability for industrial production.

Compared with the mouthwash products on the current market, the mouthwash products have the advantages that:

1. the traditional Chinese medicine mouthwash as a novel mouthwash has the effects of clearing away heat and toxic materials, promoting the production of body fluid to quench thirst, diminishing inflammation and inhibiting bacteria besides the effects of refreshing breath and cleaning teeth of the conventional mouthwash.

2. No toxic and side effects: the main component of the product is traditional Chinese medicine extract, and the product does not generate drug resistance and has no toxic or side effect on human bodies.

3. Antibacterial and anti-inflammatory effects: the traditional Chinese medicine components in the product have the effects of resisting bacteria and diminishing inflammation, can effectively prevent bacteria in the oral cavity from breeding, and creates a healthy environment for the oral cavity.

4. The safety is high: when consumers take the mouthwash, a small amount of mouthwash can be swallowed inevitably, and the prescription medicines of the product are all medicine-food homologous traditional Chinese medicines and are harmless to human bodies when being swallowed into the stomach. And the herbal medicine is used for refreshing breath, so that the medicine is safer and more effective.

5. And (3) injury reduction: the product does not contain ethanol, and has low harm to oral mucosa compared with most of mouth washes in the market.

Detailed Description

The following embodiments are used to further describe the anti-inflammatory and fluid-engendering traditional Chinese medicine mouthwash of the present invention.

The anti-inflammatory and salivation promoting traditional Chinese medicine mouth wash prepared in the embodiment 1-5 is characterized in that the ingredients of the traditional Chinese medicine extract are shown in Table 1

TABLE 1 ingredient table of Chinese medicine extract

The preparation method of the traditional Chinese medicine extract comprises the following specific steps:

decocting radix Ophiopogonis, radix asparagi, mume fructus, semen Scaphii Lychnophori, fructus Siraitiae Grosvenorii, radix Glehniae, herba Dendrobii, lalang grass rhizome, pericarpium Citri Tangerinae, herba Menthae, flos Chrysanthemi, flos Lonicerae, rhizoma Bletillae and sanguis Draxonis with water for three times, the first time with 10 times of water for 1.5 hr, and the second and third times with 8 times of water for 1 hr; mixing extractive solutions, filtering, standing for 48 hr, collecting supernatant, and concentrating under reduced pressure until the specific gravity is 1.10 to obtain Chinese medicinal extract.

The contents of the anti-inflammatory and salivation promoting traditional Chinese medicine mouth wash prepared in the embodiments 1 to 5 are shown in Table 2

TABLE 2 anti-inflammatory and salivation promoting Chinese medicinal mouthwash component content

The preparation method of the traditional Chinese medicine mouthwash for diminishing inflammation and promoting the secretion of saliva comprises the following specific steps:

adding the traditional Chinese medicine extract, citric acid, xylitol and domiphen bromide into a mixing container, adding part of deionized water, mixing, filtering, adding the rest of deionized water, filling, inspecting, and warehousing.

Example 1-5 efficacy tests of the anti-inflammatory and salivation-promoting Chinese medicinal mouthwash product.

Examples of clinical or pharmacological effects:

1. inhibitory effect on ulcerative stomatitis

The patients with oral ulcer had 100 persons in total, and were randomly divided into 10 groups of 10 persons each. The mouthwashes obtained in the above mouthwashes of examples 1 to 5 and 5 kinds of commercially available mouthwashes were treated separately, and were used 5 times a day, and were treated by rinsing with 10ml of the mouthwashes for 3 days. The results are shown in Table 3:

TABLE 310 mouthwash products have an inhibitory effect on ulcerative stomatitis

Group of	Recovery (recovery rate)	Effective (effective rate)	Ineffectiveness (inefficiency)
				Example 1	9(90％)	1(10％)	0(0)
Example 2	8(80％)	2(20％)	0(0)
				Example 3	8(80％)	2(20％)	0(0)
Example 4	7(70％)	3(30％)	0(0)
				Example 5	7(70％)	2(20％)	1(10％)
Lischdelin	1(10％)	3(30％)	6(60％)
				Black man	3(30％)	5(50％)	2(20％)
Happy tooth	0(0)	2(20％)	8(80％)
				Shuke (medicine for curing diabetes)	2(20％)	6(60％)	2(20％)
Oule B	1(10％)	4(40％)	5(50％)

The evaluation criteria of the curative effect are as follows:

and (3) healing: the oral ulcer wound surface is healed, the pain disappears, and the food intake is not influenced.

The method has the following advantages: the ulcer area of the oral cavity is reduced, the number of ulcers is reduced, the pain is obviously improved, and the oral cavity can be fed with liquid food.

And (4) invalidation: the ulcer is not reduced, the pain symptom is not obviously improved, and the food intake is influenced.

The test result shows that: the traditional Chinese medicine mouthwash for diminishing inflammation and promoting the secretion of saliva has a very good effect on dental ulcer, can effectively treat conventional dental ulcer, can keep the healing and effective rates at 90% or above, and is obviously higher than the curative effects of 5 commercially available mouthwash products.

2. Promoting effect on promoting production of body fluid to quench thirst

The patients with long-term dry mouth and tongue had 100 persons, and were randomly divided into 10 groups of 10 persons each. The mouthwashes obtained in the above mouthwashes of examples 1 to 5 and 5 kinds of commercially available mouthwashes were taken and subjected to mouth rinsing treatment 5 times a day, and 10ml of the mouthwashes were subjected to mouth rinsing treatment for 3 days. The results are shown in Table 4:

table 410 promoting effects of mouth wash products on promoting production of body fluid to quench thirst

The evaluation standard of the promoting effect of promoting the secretion of saliva and slaking thirst is as follows:

the effect is shown: the mouth is not dry, and the tongue is moist and fine.

The method has the following advantages: the dry mouth and tongue phenomenon is a certain environment.

And (4) invalidation: the symptoms are not obviously improved after treatment.

The test result shows that: the traditional Chinese medicine mouthwash for diminishing inflammation and promoting the secretion of saliva or body fluid has very good promotion effect on promoting the secretion of saliva or body fluid to quench thirst, can effectively treat the conventional symptoms of dry mouth and tongue, has obvious effect and effective rate of basically reaching 100% level in total, and is obviously higher than the curative effect of 5 commercially available mouthwash products.

3. Heat-clearing and detoxifying effect on swelling and aching of gum

The patients with swelling and aching gum had 100 persons in total, and were randomly divided into 10 groups of 10 persons each. The mouthwashes obtained in the above mouthwashes of examples 1 to 5 and 5 kinds of commercially available mouthwashes were taken and subjected to mouth rinsing treatment 5 times a day, and 10ml of the mouthwashes were subjected to mouth rinsing treatment for 3 days. The results are shown in Table 5:

table 510 collutory products with heat-clearing and detoxifying effects on gingival swelling and pain

Group of	Recovery (recovery rate)	Effective (effective rate)	Ineffectiveness (inefficiency)
				Example 1	10(100％)	0(0)	0(0)
Example 2	8(80％)	2(20％)	0(0)
				Example 3	8(80％)	2(20％)	0(0)
Example 4	9(90％)	1(10％)	0(0)
				Example 5	9(90％)	1(10％)	0(0)
Lischdelin	1(10％)	3(30％)	6(60％)
				Black man	3(30％)	1(10％)	6(60％)
Happy tooth	3(30％)	4(40％)	3(30％)
				Shuke (medicine for curing diabetes)	2(20％)	3(30％)	5(50％)
Oule B	2(20％)	4(40％)	4(40％)

The evaluation standard of the heat-clearing and detoxifying effects of the swelling and aching gum is as follows:

and (3) healing: the swelling and aching symptoms of the gum disappear.

The method has the following advantages: swelling and pain symptoms are significantly reduced.

And (4) invalidation: the symptoms of swelling and aching of gum are not obviously improved.

The test result shows that: the traditional Chinese medicine mouthwash for diminishing inflammation and promoting the secretion of saliva or body fluid has a very good treatment effect on the swelling and aching of gum, can effectively treat the conventional swelling and aching of gum, and has the recovery and effective rate of more than 90 percent, which is obviously higher than the curative effect of 5 commercially available mouthwash products.

In conclusion, the anti-inflammation and saliva-engendering traditional Chinese medicine mouthwash product has the effects of clearing heat and removing toxicity, engendering liquid and quenching thirst, diminishing inflammation and inhibiting bacteria, is nonirritant, and does not generate drug resistance and has no toxic or side effect on a human body. Can effectively inhibit oral bacteria, remove oral odor, has good effects of cleaning and caring oral cavity, and simultaneously prevents occurrence and development of oral diseases.

The foregoing is merely exemplary and illustrative of the principles of the present invention and various modifications, additions and substitutions of the specific embodiments described herein may be made by those skilled in the art without departing from the principles of the present invention or exceeding the scope of the claims set forth herein.

Claims (6)

1. The traditional Chinese medicine mouth wash for diminishing inflammation and promoting secretion of saliva contains traditional Chinese medicine extracts, and is characterized in that the traditional Chinese medicine extracts are prepared from the following traditional Chinese medicine raw materials in parts by weight:

2. the anti-inflammatory and salivation promoting traditional Chinese medicine mouth wash of claim 1, wherein the traditional Chinese medicine extract is prepared from the following traditional Chinese medicine raw materials in parts by weight:

3. the anti-inflammatory and salivation promoting traditional Chinese medicine mouth wash of claim 2, wherein the traditional Chinese medicine extract is prepared from the following traditional Chinese medicine raw materials in parts by weight:

4. the anti-inflammatory and salivation promoting traditional Chinese medicine mouth wash as claimed in any one of claims 1 to 3, which is characterized by comprising the following components in parts by weight, calculated as 100 g:

5. the anti-inflammatory and salivation promoting traditional Chinese medicine mouth wash as claimed in claim 4, which comprises the following components in parts by weight, calculated as 100 g:

6. a method for preparing the anti-inflammatory and salivation promoting traditional Chinese medicine mouthwash according to claim 4 or 5, comprising the following steps:

1) preparation of Chinese medicine extract

Decocting radix Ophiopogonis, radix asparagi, mume fructus, semen Scaphii Lychnophori, fructus Siraitiae Grosvenorii, radix Glehniae, herba Dendrobii, lalang grass rhizome, pericarpium Citri Tangerinae, herba Menthae, flos Chrysanthemi, flos Lonicerae, rhizoma Bletillae and sanguis Draxonis with water for three times, the first time with 10 times of water for 1.5 hr, and the second and third times with 8 times of water for 1 hr; mixing extractive solutions, filtering, standing for 48 hr, collecting supernatant, and concentrating under reduced pressure to specific gravity of 1.10;

2) preparation of traditional Chinese medicine mouth wash for diminishing inflammation and promoting fluid production

Adding the traditional Chinese medicine extract, citric acid, xylitol and domiphen bromide into a mixing container, adding part of deionized water, mixing, filtering, adding the rest of deionized water, filling, inspecting, and warehousing.