CN107158120A - Oral cavity anti-inflammatory spray, preparation method and application - Google Patents
Oral cavity anti-inflammatory spray, preparation method and application Download PDFInfo
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- CN107158120A CN107158120A CN201710466717.9A CN201710466717A CN107158120A CN 107158120 A CN107158120 A CN 107158120A CN 201710466717 A CN201710466717 A CN 201710466717A CN 107158120 A CN107158120 A CN 107158120A
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
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- A61K31/19—Carboxylic acids, e.g. valproic acid
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/194—Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
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- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/534—Mentha (mint)
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- A61K36/57—Magnoliaceae (Magnolia family)
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- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
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Abstract
The present invention relates to oral care techniques field, and in particular to a kind of oral cavity anti-inflammatory spray, preparation method and application.The oral cavity anti-inflammatory spray that the present invention is provided, contain Magnolia cortex P.E and Honegsukle flower P.E, growing for oral cavity bacterium can be suppressed, eliminate oral peculiar smell, reduce dental plaque, gingivitis, periodontitis, canker sore, carious tooth or halitosis can be prevented and treated, there is instant effect, good effect, safety non-toxic and uneasy to recur.The preparation method for the oral cavity anti-inflammatory spray that the present invention is provided, rational technology is effectively extracted the active ingredient in the bark of official magnolia and honeysuckle, and retains complete, and spray is made together with other components, is conducive to the absorption of medicine, medicine is preferably played a role.
Description
Technical field
The present invention relates to oral care techniques field, and in particular to a kind of oral cavity anti-inflammatory spray, preparation method and application.
Background technology
Mouth disease refers to oral cavity in the infringement of extraneous physical and chemical factor, the intrusion of cause of disease, jaw dysplasia and complete
The pathological phenomenon occurred when body disease, as periodontitis, pharyngitis, lip chamber ulcer and due to indigestion caused by halitosis
Deng.
Mouth disease can cause some to influence whole body health and quality of life, as halitosis peculiar smell may influence us
Image, tooth mobility comes off, chronic oral pain etc. can influence our intakes to food, causes the unbalanced of nutrition intake,
Severe patient even can cause the diseases such as carcinoma of mouth, septicemia, diabetes and other angiocarpy.
For a long time, the treatment to mouth disease uses chemistry, antibiotics mostly, although playing at that time certain
Effect, but with the Reusability of medicine, a series of adverse effect is brought, such as develop immunity to drugs bacterial strain, secondary to the poison of body
Effect.
By in consideration of it, proposing the present invention.
The content of the invention
, can containing Magnolia cortex P.E and Honegsukle flower P.E it is an object of the invention to provide a kind of oral cavity anti-inflammatory spray
Suppress growing for oral cavity bacterium, eliminate oral peculiar smell, reduce dental plaque, gingivitis, periodontitis, mouth can be prevented and treated
Chamber ulcer, carious tooth or halitosis, are a kind of instant effect, good effect, safety non-toxic, anti-inflammatory spray in oral cavity uneasy to recur.
Another object of the present invention is to provide a kind of preparation method of oral cavity anti-inflammatory spray, rational technology can be effective
The active ingredient in the bark of official magnolia and honeysuckle is extracted, and retains complete, and spray is made together with other components, is conducive to medicine
Absorption, medicine is preferably played a role.
To achieve the above object, the technical solution adopted by the present invention is：
A kind of oral cavity anti-inflammatory spray, including the following raw material counted by weight：20-100 parts of Magnolia cortex P.E, gold and silver
20-100 parts of flower extract, 5-15 parts of Radix Notoginseng powder, 3-6 parts of natural plant essential oils, 100-150 parts of sodium citrate, citric acid
1800-2200 parts of 2-6 parts, 5-10 parts of sodium chloride, 50-100 parts of sodium acetate, 10-30 parts of potassium acetate and water.
Further, the oral cavity anti-inflammatory spray includes the following raw material counted by weight：Magnolia cortex P.E 40-80
Part, 40-80 parts of Honegsukle flower P.E, 8-12 parts of Radix Notoginseng powder, 2-5 parts of natural plant essential oils, 110-140 parts of sodium citrate,
1900-2100 parts of 3-5 parts of citric acid, 6-9 parts of sodium chloride, 60-80 parts of sodium acetate, 15-25 parts of potassium acetate and water.
Further, the oral cavity anti-inflammatory spray includes the following raw material counted by weight：60 parts of Magnolia cortex P.E,
60 parts of Honegsukle flower P.E, 10 parts of Radix Notoginseng powder, 4 parts of natural plant essential oils, 125 parts of sodium citrate, 4 parts of citric acid, sodium chloride 7
Part, 70 parts of sodium acetate, 20 parts of potassium acetate and 2000 parts of water.
Further, the natural plant essential oils are lemon or Peppermint essential oil.
The preparation method of above-mentioned oral cavity anti-inflammatory spray, comprises the following steps：
(a) Magnolia cortex P.E, Honegsukle flower P.E, Radix Notoginseng powder and natural plant essential oils are weighed by weight, are dissolved in portion
Divide in water, obtain solution A, it is standby；
(b) weigh by weight and sodium citrate, citric acid, sodium chloride, sodium acetate, potassium acetate are dissolved in remainder water
In, solution B is obtained, is heated to after 55-65 DEG C, the solution A that step (a) is obtained is added, normal temperature is cooled to after being well mixed,
Obtain oral cavity anti-inflammatory spray.
Further, the Magnolia cortex P.E is prepared as follows：The bark of official magnolia is crushed to 10-100 mesh, used
30-90% ethanol solutions extract the bark of official magnolia 2-4 times, merge extract solution, are concentrated；Macroporous resin adsorption is used again, uses 50-
99% ethanol solution is eluted, and is collected eluent, is concentrated under reduced pressure to give Magnolia cortex P.E.
Further, the Honegsukle flower P.E is prepared as follows：Honeysuckle powder is broken to 10-100
Mesh, honeysuckle is extracted 2-4 times with 30-90% ethanol solutions, is merged extract solution, is concentrated；Macroporous resin adsorption is used again, is used
50-99% ethanol solutions are eluted, and are collected eluent, are concentrated under reduced pressure to give Honegsukle flower P.E.
Further, the temperature for the bark of official magnolia being extracted with 30-90% ethanol solutions is 30-100 DEG C, and each extraction time is
1-3h.
Further, the temperature for honeysuckle being extracted with 30-90% ethanol solutions is 30-100 DEG C, each extraction time
For 1-3h.
Above-mentioned oral cavity anti-inflammatory spray treat mouth disease in terms of application, for treat carious tooth, gingivitis, periodontitis or
Halitosis.
Compared with prior art, the beneficial effects of the present invention are：
1. the oral cavity anti-inflammatory spray that the present invention is provided, containing Magnolia cortex P.E and Honegsukle flower P.E, can suppress in oral cavity
Growing for bacterium, eliminates oral peculiar smell, reduces dental plaque, can prevent and treat gingivitis, periodontitis, canker sore, dental caries
Tooth or halitosis, have the advantages that instant effect, good effect, safety non-toxic and uneasy to recur.
2. the preparation method for the oral cavity anti-inflammatory spray that the present invention is provided, rational technology is effectively extracted the bark of official magnolia and honeysuckle
In active ingredient, and retain complete, and spray is made together with other components, be conducive to the absorption of medicine, make medicine more
Play a role well.
Embodiment
Technical scheme is clearly and completely described below in conjunction with embodiment, it is clear that described reality
It is a part of embodiment of the invention to apply example, rather than whole embodiments.Based on the embodiment in the present invention, the common skill in this area
The every other embodiment that art personnel are obtained under the premise of creative work is not made, belongs to the model that the present invention is protected
Enclose.
A kind of oral cavity anti-inflammatory spray, including the following raw material counted by weight：20-100 parts of Magnolia cortex P.E, gold and silver
20-100 parts of flower extract, 5-15 parts of Radix Notoginseng powder, 3-6 parts of natural plant essential oils, 100-150 parts of sodium citrate, citric acid
1800-2200 parts of 2-6 parts, 5-10 parts of sodium chloride, 50-100 parts of sodium acetate, 10-30 parts of potassium acetate and water.
Magnolia cortex P.E is to extract active ingredient from Cortex Magnoliae Officinalis skin.The bark of official magnolia is that the Magnoliacea plant bark of official magnolia and recessed leaf are thick
Dry bark, root skin and the branch skin of Piao；Its is warm-natured, bitterly；Returns spleen, stomach, lung, large intestine channel, with anti-inflammatory sterilization and analgesic
Effect, there is stronger antibacterial or bactericidal action to cariogenic bacteria.Active ingredient in Magnolia cortex P.E is honokiol, magnolol and
Magnolia bark total-phenol.Active deformation streptococcus, streptococcus sobrinus, actinomyces viscosus, lactobacillus are considered as most important cariogenic bacteria, it
By the adhesion to facing, form bacterial plaque, tooth is produced dental caries bad, therefore suppress and kill cariogenic bacteria to have pre- anti-caries
Play the role of important.Magnolol in the bark of official magnolia has significant antibacterial activity to grampostive bacteria, acid resistance bacterium, filamentous fungi,
Particularly there is more significant antibacterial to streptococcus mutans.
In the present invention, Magnolia cortex P.E is typical but non-limiting content is：20 parts, 25 parts, 30 parts, 35 parts, 40 parts, 45
Part, 50 parts, 55 parts, 60 parts, 65 parts, 70 parts, 75 parts, 80 parts, 85 parts, 90 parts, 95 parts or 100 parts.
Honegsukle flower P.E is the active ingredient extracted from natural honeysuckle.Honeysuckle is caprifoliaceae plant honeysuckle
Dry flower；It is sweet, cold in nature；Return lung, the heart, stomach；It is thin with clearing heat and detoxicating, suppression epidermis with certain bacteriostasis
The functions such as bacterium infection.Active ingredient in Honegsukle flower P.E is chlorogenic acid, and chlorogenic acid has the effect of anti-inflammation.Honeysuckle
For streptococcus, staphylococcus, typhoid bacillus, shigella dysenteriae, large intestine and Pseudomonas aeruginosa, Diplococcus pneumopniae, Bordetella pertussis, brain
Meningococcus etc., there is stronger inhibitory action.Flos Lonicerae extractive solution is to causing the streptococcus mutans and unwrapping wire Bacillus adhaerens of dental caries
And cause the bacteroides melanogenicus of periodontosis, gingivitis bacillus and stronger bacteriostatic activity is shown with unwrapping wire haemophilic bacterium.
In the present invention, Honegsukle flower P.E is typical but non-limiting content is：20 parts, 25 parts, 30 parts, 35 parts, 40 parts, 45
Part, 50 parts, 55 parts, 60 parts, 65 parts, 70 parts, 75 parts, 80 parts, 85 parts, 90 parts, 95 parts or 100 parts.
Radix Notoginseng powder is the powder that Chinese medicine pseudo-ginseng breaks into, and has effects that hemostasis, dissipates the stasis of blood, analgesic therapy.Pseudo-ginseng is Araliaceae three
Seven dry root；Sweet, slight bitter, it is warm-natured；Return liver, stomach；There is dissipate stasis of blood hemostasis, detumescence ding-tong.Radix Notoginseng powder can be prevented
All kinds of bleeding gums, have good therapeutic effect to chronic gingivitis, chronic periodontitis, canker sore etc..
In the present invention, Radix Notoginseng powder is typical but non-limiting content is：5 parts, 6 parts, 7 parts, 8 parts, 9 parts, 10 parts, 11 parts, 12
Part, 13 parts, 14 parts or 15 parts.
Natural plant essential oils are the oily liquids with high volatility and special aromatic odor extracted from plant, tool
There are antibacterial, anti-inflammatory, the anti-oxidant, function such as calm and antitumor of calming the nerves.Natural plant essential oils to a variety of main oral cavity pathogens,
Such as streptococcus sobrinus, Streptococcus mutans, porphyromonas gingivalis, candida albicans bacterium have inhibitory action, and have special
Aromatic odor, in dentistry field, the preventing and treating of such as dental caries, the preventing and treating of periodontosis, the preventing and treating of oral mucosal disease have well
Application prospect.
In the present invention, natural plant essential oils are typical but non-limiting content is：2 parts, 2.5 parts, 3 parts, 3.5 parts, 4 parts, 4.5
Part or 5 parts.
As the preferred embodiment of the present invention, the natural plant essential oils are lemon or Peppermint essential oil.
Sodium citrate and citric acid are used for the pH for adjusting oral cavity anti-inflammatory spray, while removing removing abnormal flavor in oral cavity, eliminate halitosis.
In the present invention, sodium citrate is typical but non-limiting content is：100 parts, 105 parts, 110 parts, 115 parts, 120 parts,
125 parts, 130 parts, 135 parts, 140 parts, 145 parts or 150 parts.
In the present invention, citric acid is typical but non-limiting content is 2 parts, 2.5 parts, 3 parts, 3.5 parts, 4 parts, 4.5 parts or 5
Part.
Sodium chloride has bactericidal action, is conducive to eliminating the bacterium in oral cavity, plays a part of anti-inflammatory analgetic, contribute to more
Take good care of oral cavity and throat well.
In the present invention, sodium chloride is typical but non-limiting content is 5 parts, 6 parts, 7 parts, 8 parts, 9 parts or 10 parts.
Sodium acetate and potassium acetate are used for the pH for adjusting oral cavity anti-inflammatory spray, while being conducive to removing tartar.
In the present invention, sodium acetate is typical but non-limiting content is 50 parts, 55 parts, 60 parts, 65 parts, 70 parts, 75 parts, 80
Part, 85 parts, 90 parts, 95 parts or 100 parts.
In the present invention, potassium acetate is typical but non-limiting content is 10 parts, 12 parts, 15 parts, 18 parts, 20 parts, 22 parts, 25
Part, 28 parts or 30 parts.
Magnolia cortex P.E and Honegsukle flower P.E in the oral cavity anti-inflammatory spray that the present invention is provided, have to oral cavity malignant bacteria
Stronger antibacterial or bactericidal action, Radix Notoginseng powder can prevent all kinds of bleeding gums, and there is natural plant essential oils bactericidal action also to contain
Aromatic odor, sodium chloride has antiinflammation, and sodium citrate, citric acid, sodium acetate and potassium acetate are used for the pH for adjusting spray, led to
The coordinated effect of each component is crossed, growing for oral cavity bacterium can be suppressed, oral peculiar smell is eliminated, dental plaque is reduced.
It should be noted that the beneficial effect of the oral cavity anti-inflammatory spray of the present invention is by its specific raw material components and proportioning
Determined, if component and its not mutually coordinated, the beneficial effect that single component is brought of proportioning, it is likely that can be by other components
Abatement is even eliminated, and does not have whole synthesis effect.The present invention is by substantial amounts of research and verifies repeatedly, has obtained oral cavity anti-inflammatory
The optimum combination and proportioning of spray so that multiple components combine, mutually coordinated, the positive synergy of generation, suppress mouth
Growing for intracavitary bacterium, eliminates oral peculiar smell, can prevent and treat gingivitis, periodontitis, canker sore, carious tooth or halitosis.
As the optional embodiment of the present invention, the oral cavity anti-inflammatory spray includes the following raw material counted by weight：
40-80 parts of Magnolia cortex P.E, 40-80 parts of Honegsukle flower P.E, 8-12 parts of Radix Notoginseng powder, 2-5 parts of natural plant essential oils, lemon
Sour sodium 110-140 parts, 3-5 parts of citric acid, 6-9 parts of sodium chloride, 60-80 parts of sodium acetate, 15-25 parts of potassium acetate and water
1900-2100 parts.
As the preferred embodiment of the present invention, the oral cavity anti-inflammatory spray includes the following raw material counted by weight：
60 parts of Magnolia cortex P.E, 60 parts of Honegsukle flower P.E, 10 parts of Radix Notoginseng powder, 4 parts of natural plant essential oils, 125 parts of sodium citrate, lemon
2000 parts of 4 parts of acid, 7 parts of sodium chloride, 70 parts of sodium acetate, 20 parts of potassium acetate and water.
Present invention also offers the preparation method of oral cavity anti-inflammatory spray, comprise the following steps：
(a) Magnolia cortex P.E, Honegsukle flower P.E, Radix Notoginseng powder and natural plant essential oils are weighed by weight, are dissolved in portion
Divide in water, obtain solution A, it is standby；
(b) weigh by weight and sodium citrate, citric acid, sodium chloride, sodium acetate, potassium acetate are dissolved in remainder water
In, solution B is obtained, is heated to after 55-65 DEG C, the solution A that step (a) is obtained is added, normal temperature is cooled to after being well mixed,
Obtain oral cavity anti-inflammatory spray.
In the present invention, the Magnolia cortex P.E is prepared as follows：The bark of official magnolia is crushed to 10-100 mesh, used
30-90% ethanol solutions extract the bark of official magnolia 2-4 times, merge extract solution, are concentrated, obtain crude extract；Then to coarse extraction
Thing is further purified, specifically, uses macroporous resin adsorption crude extract, is eluted with 50-99% ethanol solutions, is received
Collect eluent, be concentrated under reduced pressure to give Magnolia cortex P.E.
As the optional embodiment of the present invention, the temperature that the bark of official magnolia is extracted with 30-90% ethanol solutions is 30-100 DEG C,
Each extraction time is 1-3h.
In the present invention, the Honegsukle flower P.E is prepared as follows：Honeysuckle powder is broken to 10-100
Mesh, honeysuckle is extracted 2-4 times with 30-90% ethanol solutions, is merged extract solution, is concentrated, obtain crude extract；Then it is right
Crude extract is further purified, specifically, with macroporous resin adsorption, is eluted with 50-99% ethanol solutions, is collected
Eluent, is concentrated under reduced pressure to give Honegsukle flower P.E.
As the optional embodiment of the present invention, the temperature that honeysuckle is extracted with 30-90% ethanol solutions is 30-100
DEG C, each extraction time is 1-3h.
The preparation method for the mouth sprays that the present invention is provided, can effectively extract the active ingredient in the bark of official magnolia and honeysuckle,
And spray is made together with other components, be conducive to the absorption of medicine, medicine is preferably played a role, preparation technology rationally has
Effect.
Above-mentioned oral cavity anti-inflammatory spray treat mouth disease in terms of application, for treat carious tooth, gingivitis, periodontitis or
Halitosis.
The oral cavity anti-inflammatory spray provided with reference to specific embodiment the present invention is further expalined.
Embodiment 1
The oral cavity anti-inflammatory spray that embodiment 1 is provided, including the following raw material counted by weight：60 parts of Magnolia cortex P.E,
60 parts of Honegsukle flower P.E, 10 parts of Radix Notoginseng powder, 4 parts of natural plant essential oils, 125 parts of sodium citrate, 4 parts of citric acid, sodium chloride 7
Part, 70 parts of sodium acetate, 20 parts of potassium acetate and 2000 parts of water.
Prepared in accordance with the following steps：
(a) Magnolia cortex P.E, Honegsukle flower P.E, Radix Notoginseng powder and natural plant essential oils are weighed by weight, are dissolved in
In 1000 parts of water, solution A is obtained, it is standby；
(b) weigh by weight and sodium citrate, citric acid, sodium chloride, sodium acetate, potassium acetate are dissolved in 1000 parts of water
In, solution B is obtained, is heated to after 60 DEG C, the solution A that step (a) is obtained is added, normal temperature is cooled to after being well mixed, obtains
Oral cavity anti-inflammatory spray.
Wherein, Magnolia cortex P.E is prepared as follows：The bark of official magnolia is crushed to 10-100 mesh, respectively with 50%,
70% and 90% ethanol solution extracts the bark of official magnolia, and the temperature for extracting the bark of official magnolia is 70 DEG C, and each extraction time is 2h, merges and extracts
Liquid, is concentrated, and obtains crude extract；Then macroporous resin adsorption crude extract is used, is eluted with 70% ethanol solution, is received
Collect eluent, be concentrated under reduced pressure to give Magnolia cortex P.E.
Honegsukle flower P.E is prepared as follows：Honeysuckle powder is broken to 10-100 mesh, respectively with 30%,
60% and 90% ethanol solution extracts honeysuckle, and the temperature for extracting honeysuckle is 70 DEG C, and each extraction time is 2h, and merging is carried
Liquid is taken, is concentrated, crude extract is obtained；Then macroporous resin adsorption crude extract is used, is eluted with 75% ethanol solution,
Eluent is collected, Honegsukle flower P.E is concentrated under reduced pressure to give.
Embodiment 2
The oral cavity anti-inflammatory spray that embodiment 2 is provided, including the following raw material counted by weight：40 parts of Magnolia cortex P.E,
80 parts of Honegsukle flower P.E, 8 parts of Radix Notoginseng powder, 5 parts of natural plant essential oils, 110 parts of sodium citrate, 5 parts of citric acid, 6 parts of sodium chloride,
2100 parts of 80 parts of sodium acetate, 15 parts of potassium acetate and water.
Prepared in accordance with the following steps：
(a) Magnolia cortex P.E, Honegsukle flower P.E, Radix Notoginseng powder and natural plant essential oils are weighed by weight, are dissolved in
In 1300 parts of water, solution A is obtained, it is standby；
(b) weigh by weight and sodium citrate, citric acid, sodium chloride, sodium acetate, potassium acetate be dissolved in 800 parts of water,
Solution B is obtained, is heated to after 58 DEG C, the solution A that step (a) is obtained is added, normal temperature is cooled to after being well mixed, obtains oral cavity
Anti-inflammatory spray.
Wherein, Magnolia cortex P.E is prepared as follows：The bark of official magnolia is crushed to 10-100 mesh, respectively with 30%,
50%th, 70% and 90% ethanol solution extracts the bark of official magnolia, and the temperature for extracting the bark of official magnolia is 50 DEG C, and each extraction time is 3h, is merged
Extract solution, is concentrated, and obtains crude extract；Then macroporous resin adsorption crude extract is used, is washed with 60% ethanol solution
It is de-, eluent is collected, Magnolia cortex P.E is concentrated under reduced pressure to give.
Honegsukle flower P.E is prepared as follows：Honeysuckle powder is broken to 10-100 mesh, respectively with 45% He
85% ethanol solution extracts honeysuckle, and the temperature for extracting honeysuckle is 90 DEG C, and each extraction time is 1h, merges extract solution, enters
Row concentration, obtains crude extract；Then macroporous resin adsorption crude extract is used, is eluted with 80% ethanol solution, collection is washed
De- liquid, is concentrated under reduced pressure to give Honegsukle flower P.E.
Embodiment 3
The oral cavity anti-inflammatory spray that embodiment 3 is provided, including the following raw material counted by weight：80 parts of Magnolia cortex P.E,
40 parts of Honegsukle flower P.E, 12 parts of Radix Notoginseng powder, 2 parts of natural plant essential oils, 140 parts of sodium citrate, 3 parts of citric acid, sodium chloride 9
Part, 60 parts of sodium acetate, 25 parts of potassium acetate and 1900 parts of water.
Prepared in accordance with the following steps：
(a) Magnolia cortex P.E, Honegsukle flower P.E, Radix Notoginseng powder and natural plant essential oils are weighed by weight, are dissolved in
In 1050 parts of water, solution A is obtained, it is standby；
(b) weigh by weight and sodium citrate, citric acid, sodium chloride, sodium acetate, potassium acetate be dissolved in 850 parts of water,
Solution B is obtained, is heated to after 62 DEG C, the solution A that step (a) is obtained is added, normal temperature is cooled to after being well mixed, obtains oral cavity
Anti-inflammatory spray.
Wherein, Magnolia cortex P.E is prepared as follows：The bark of official magnolia is crushed to 10-100 mesh, respectively with 40%
Ethanol solution with 80% extracts the bark of official magnolia, and the temperature for extracting the bark of official magnolia is 80 DEG C, and each extraction time is 1.5h, merges extract solution,
Concentrated, obtain crude extract；Then macroporous resin adsorption crude extract is used, is eluted with 85% ethanol solution, is collected
Eluent, is concentrated under reduced pressure to give Magnolia cortex P.E.
Honegsukle flower P.E is prepared as follows：Honeysuckle powder is broken to 10-100 mesh, respectively with 30%,
50%th, 70% and 90% ethanol solution extracts honeysuckle 4 times, and the temperature for extracting honeysuckle is 40 DEG C, and each extraction time is
2.5h, merges extract solution, is concentrated, obtain crude extract；Then macroporous resin adsorption crude extract is used, it is molten with 75% ethanol
Liquid is eluted, and is collected eluent, is concentrated under reduced pressure to give Honegsukle flower P.E.
Embodiment 4
The oral cavity anti-inflammatory spray that embodiment 4 is provided, including the following raw material counted by weight：20 parts of Magnolia cortex P.E,
100 parts of Honegsukle flower P.E, 5 parts of Radix Notoginseng powder, 6 parts of natural plant essential oils, 100 parts of sodium citrate, 6 parts of citric acid, sodium chloride 5
Part, 100 parts of sodium acetate, 10 parts of potassium acetate and 2200 parts of water.
Prepared in accordance with the following steps：
(a) Magnolia cortex P.E, Honegsukle flower P.E, Radix Notoginseng powder and natural plant essential oils are weighed by weight, are dissolved in
In 1600 parts of water, solution A is obtained, it is standby；
(b) weigh by weight and sodium citrate, citric acid, sodium chloride, sodium acetate, potassium acetate be dissolved in 600 parts of water,
Solution B is obtained, is heated to after 55 DEG C, the solution A that step (a) is obtained is added, normal temperature is cooled to after being well mixed, obtains oral cavity
Anti-inflammatory spray.
Wherein, Magnolia cortex P.E is prepared as follows：The bark of official magnolia is crushed to 10-100 mesh, respectively with 40%,
60% and 80% ethanol solution extracts the bark of official magnolia, and the temperature for extracting the bark of official magnolia is 60 DEG C, and each extraction time is 2h, merges and extracts
Liquid, is concentrated, and obtains crude extract；Then macroporous resin adsorption crude extract is used, is eluted with 55% ethanol solution, is received
Collect eluent, be concentrated under reduced pressure to give Magnolia cortex P.E.
Honegsukle flower P.E is prepared as follows：Honeysuckle powder is broken to 10-100 mesh, respectively with 40%,
65% and 90% ethanol solution extracts honeysuckle, and the temperature for extracting honeysuckle is 70 DEG C, and each extraction time is 2.5h, is merged
Extract solution, is concentrated, and obtains crude extract；Then macroporous resin adsorption crude extract is used, is washed with 80% ethanol solution
It is de-, eluent is collected, Honegsukle flower P.E is concentrated under reduced pressure to give.
Embodiment 5
The oral cavity anti-inflammatory spray that embodiment 5 is provided, including the following raw material counted by weight：100 parts of Magnolia cortex P.E,
20 parts of Honegsukle flower P.E, 15 parts of Radix Notoginseng powder, 3 parts of natural plant essential oils, 150 parts of sodium citrate, 2 parts of citric acid, sodium chloride 10
Part, 50 parts of sodium acetate, 30 parts of potassium acetate and 1800 parts of water.
Prepared in accordance with the following steps：
(a) Magnolia cortex P.E, Honegsukle flower P.E, Radix Notoginseng powder and natural plant essential oils are weighed by weight, are dissolved in 700
In part water, solution A is obtained, it is standby；
(b) weigh by weight and sodium citrate, citric acid, sodium chloride, sodium acetate, potassium acetate are dissolved in 1100 parts of water
In, solution B is obtained, is heated to after 65 DEG C, the solution A that step (a) is obtained is added, normal temperature is cooled to after being well mixed, obtains
Oral cavity anti-inflammatory spray.
Wherein, Magnolia cortex P.E is prepared as follows：The bark of official magnolia is crushed to 10-100 mesh, respectively with 45%,
65% and 85% ethanol solution extracts the bark of official magnolia, and the temperature for extracting the bark of official magnolia is 30 DEG C, and each extraction time is 3h, merges and extracts
Liquid, is concentrated, and obtains crude extract；Then macroporous resin adsorption crude extract is used, is eluted with 95% ethanol solution, is received
Collect eluent, be concentrated under reduced pressure to give Magnolia cortex P.E.
Honegsukle flower P.E is prepared as follows：Honeysuckle powder is broken to 10-100 mesh, respectively with 55% He
85% ethanol solution extracts honeysuckle, and the temperature for extracting honeysuckle is 100 DEG C, and each extraction time is 1h, merges extract solution,
Concentrated, obtain crude extract；Then macroporous resin adsorption crude extract is used, is eluted with 65% ethanol solution, is collected
Eluent, is concentrated under reduced pressure to give Honegsukle flower P.E.
Comparative example 1
The oral cavity anti-inflammatory spray that comparative example 1 is provided includes the following raw material counted by weight：10 parts of Magnolia cortex P.E, gold
10 parts of honeysuckle flower extract, 25 parts of Radix Notoginseng powder, 10 parts of natural plant essential oils, 200 parts of sodium citrate, 10 parts of citric acid, sodium chloride 20
Part, 110 parts of sodium acetate, 40 parts of potassium acetate and 2000 parts of water.
Preparation method be the same as Example 1.
Comparative example 2
The oral cavity anti-inflammatory spray that comparative example 2 is provided includes the following raw material counted by weight：110 parts of Magnolia cortex P.E,
120 parts of Honegsukle flower P.E, 2 parts of Radix Notoginseng powder, 2 parts of natural plant essential oils, 50 parts of sodium citrate, 1 part of citric acid, 1 part of sodium chloride,
2000 parts of 30 parts of sodium acetate, 5 parts of potassium acetate and water.
Preparation method be the same as Example 1.
Comparative example 3
The oral cavity anti-inflammatory spray that comparative example 3 is provided and the difference of embodiment 1 are not containing Magnolia cortex P.E.
The clinical test of effect example 1
Mouth disease (including gingivitis, periodontitis, canker sore, carious tooth or halitosis) patient 450 is collected, wherein man
238, female 212, age 26-61 Sui, the course of disease -3 months 2 days.It is randomly divided between 8 groups, every group 50, every group in property
Not, there was no significant difference on age, the course of disease and severity extent, with comparativity.Test group 1-5 uses 1- of the embodiment of the present invention
The 5 oral cavity anti-inflammatory sprays provided, the oral cavity anti-inflammatory spray that control group 1-3 is provided using comparative example 1-3 of the present invention, control group 4
Using commercial oral anti-inflammatory spray, controlled 3 times per spray, continuous spray is controlled one month.
Treatment standard：
It is effective：Symptom disappears substantially；
Effectively：Symptom is clearly better；
It is invalid：Symptom is without improvement or but more serious.
Total effective rate=(effective example+effective percentage)/total case
Therapeutic effect of the table 1 to mouth disease
| Total case | Effective example | Effective example | Total effective rate | |
| Test group 1 | 50 | 27 | 22 | 98 |
| Test group 2 | 50 | 22 | 24 | 92 |
| Test group 3 | 50 | 23 | 24 | 94 |
| Test group 4 | 50 | 19 | 26 | 90 |
| Test group 5 | 50 | 21 | 26 | 94 |
| Control group 1 | 50 | 14 | 25 | 78 |
| Control group 2 | 50 | 18 | 24 | 84 |
| Control group 3 | 50 | 11 | 26 | 74 |
| Control group 4 | 50 | 12 | 23 | 70 |
From table 1 it follows that the test group 1-5 of the oral cavity anti-inflammatory spray provided using the present invention, to mouth disease
Therapeutic effect is up to more than 90%, and later stage follow-up, no recurrence.And the therapeutic effect of commercial oral anti-inflammatory spray only has 70%, after
Phase follow-up, there is 3 recurrences.
The oral cavity anti-inflammatory spray that comparative example 1 and comparative example 2 are provided, it constitutes and matched not in protection scope of the present invention
Interior, its therapeutic effect to mouth disease is not so good as test group 1-5, illustrate the composition of oral cavity anti-inflammatory spray and is imitated with treatment is compared
Fruit has a significant impact, and the oral cavity anti-inflammatory spray that the present invention is provided is good to the therapeutic effect of mouth disease, and without recurrence.
The effect of the oral cavity anti-inflammatory spray provided with reference to model case the present invention is illustrated.
Case 1
Lee, female, 24 years old, tooth made swelling hypodynia, and bleeding gums are serious when brushing teeth on ordinary days, gum when feeding hard food
Also can bleeding, the oral cavity anti-inflammatory spray provided using the embodiment of the present invention 1 is daily 3-4 times, and two weeks is controlled in continuous spray, and gum goes out
Blood problem is effectively alleviated, and continues spray and controls two weeks, bleeding gums problem is resolved, the later stage carries out follow-up, no relapse.
Case 2
Mr. Ji, female, 41 years old, with stomatitis, in gums, lip, each position mucous membrane of mouth such as cheek mucous membrane occur it is single or into
The exanthema vesiculosum of cluster, there is the covering of yellow-white cellulosic secretion, and multiple ulcer can be fused into irregular big ulcer, use this hair
The Traditional Chinese medicinal spray of bright embodiment 2, daily 4-5 times, continuous spray is controlled five days, and effect substantially, continues spray and controlled ten days, symptom is delayed completely
Solution, does not recur so far.
Case 3
Wei, man 32 years old, because operating pressure is big and often stays up late, causes each position oral cavities such as lip interior, tongue, cheek mucous membrane
Single or cluster the exanthema vesiculosum of mucous membrane appearance, gum hurt like hell, it is impossible to feed, patient's complexion is sent out red, bitter taste deficiency of food, and stool is dry
Knot, red tongue body, yellow tongue fur is thick, and the oral cavity anti-inflammatory spray provided using the embodiment of the present invention 3 is daily 4-6 times, and three days symptoms are controlled in spray
It is relieved, two weeks is controlled in continuous spray, and symptom is wholly absent.
Case 4
Certain is closed, man 49 years old, smokes and drink, have halitosis on ordinary days, the oral cavity anti-inflammatory provided using the embodiment of the present invention 4 is sprayed
Agent, daily 3-4 times, continuous spray is controlled one week, and halitosis is relieved, and two weeks is controlled in continuous spray, and halitosis disappears substantially.
Case 5
Certain, male together, 36 years old, on ordinary days because teeth brushing way is incorrect, and bacterial plaque is serious, is provided using the embodiment of the present invention 5
Oral cavity anti-inflammatory spray, daily 3-4 times, continuous spray is controlled 1 month, and bacterial plaque substantially mitigates.
Case 6
Song, female, 52 years old, frequent breaking-out canker sore in this year, gnawing pains take no rest, oral vitamin C and multiple during breaking-out
Closing vitamin B etc. can alleviate, but long-term taking effect is not good, the oral cavity anti-inflammatory spray provided using the embodiment of the present invention 1, daily
3-4 times, continuous spray is controlled 1 week, and canker sore disappears substantially, is continued spray and is controlled two weeks, canker sore is wholly absent, the later stage is carried out
Follow-up, no relapse.
As can be seen that the oral cavity anti-inflammatory spray that the present invention is provided can prevent and treat gum from above-mentioned model case
Inflammation, periodontitis, canker sore, carious tooth or halitosis, have the advantages that instant effect, good effect, safety non-toxic and uneasy to recur.
Finally it should be noted that：Various embodiments above is merely illustrative of the technical solution of the present invention, rather than its limitations；To the greatest extent
The present invention is described in detail with reference to foregoing embodiments for pipe, it will be understood by those within the art that：Its according to
The technical scheme described in foregoing embodiments can so be modified, or which part or all technical characteristic are entered
Row equivalent substitution；And these modifications or replacement, the essence of appropriate technical solution is departed from various embodiments of the present invention technology
The scope of scheme.
Claims (10)
1. a kind of oral cavity anti-inflammatory spray, it is characterised in that including the following raw material counted by weight：Magnolia cortex P.E 20-
100 parts, 20-100 parts of Honegsukle flower P.E, 5-15 parts of Radix Notoginseng powder, 3-6 parts of natural plant essential oils, sodium citrate 100-150
Part, 2-6 parts of citric acid, 5-10 parts of sodium chloride, 50-100 parts of sodium acetate, 10-30 parts of potassium acetate and 1800-2200 parts of water.
2. anti-inflammatory spray in oral cavity according to claim 1, it is characterised in that including the following raw material counted by weight：
40-80 parts of Magnolia cortex P.E, 40-80 parts of Honegsukle flower P.E, 8-12 parts of Radix Notoginseng powder, 2-5 parts of natural plant essential oils, lemon
Sour sodium 110-140 parts, 3-5 parts of citric acid, 6-9 parts of sodium chloride, 60-80 parts of sodium acetate, 15-25 parts of potassium acetate and water
1900-2100 parts.
3. anti-inflammatory spray in oral cavity according to claim 2, it is characterised in that including the following raw material counted by weight：
60 parts of Magnolia cortex P.E, 60 parts of Honegsukle flower P.E, 10 parts of Radix Notoginseng powder, 4 parts of natural plant essential oils, 125 parts of sodium citrate, lemon
2000 parts of 4 parts of acid, 7 parts of sodium chloride, 70 parts of sodium acetate, 20 parts of potassium acetate and water.
4. the oral cavity anti-inflammatory spray according to claim any one of 1-3, it is characterised in that the natural plant essential oils are
Lemon or Peppermint essential oil.
5. a kind of preparation method of the oral cavity anti-inflammatory spray as any one of claim 1-4, it is characterised in that including such as
Lower step：
(a) Magnolia cortex P.E, Honegsukle flower P.E, Radix Notoginseng powder and natural plant essential oils are weighed by weight, are dissolved in part water
In, solution A is obtained, it is standby；
(b) weigh by weight and sodium citrate, citric acid, sodium chloride, sodium acetate, potassium acetate be dissolved in remainder water,
Solution B is obtained, is heated to after 55-65 DEG C, the solution A that step (a) is obtained is added, normal temperature is cooled to after being well mixed, obtains
Oral cavity anti-inflammatory spray.
6. preparation method according to claim 5, it is characterised in that the Magnolia cortex P.E is made as follows
It is standby：The bark of official magnolia is crushed to 10-100 mesh, the bark of official magnolia is extracted 2-4 times with 30-90% ethanol solutions, merges extract solution, carries out dense
Contracting；Macroporous resin adsorption is used again, is eluted with 50-99% ethanol solutions, is collected eluent, is concentrated under reduced pressure to give the bark of official magnolia and carries
Take thing.
7. preparation method according to claim 5, it is characterised in that the Honegsukle flower P.E is carried out as follows
Prepare：Honeysuckle powder is broken to 10-100 mesh, honeysuckle is extracted 2-4 times with 30-90% ethanol solutions, merges extract solution, enters
Row concentration；Macroporous resin adsorption is used again, is eluted with 50-99% ethanol solutions, is collected eluent, is concentrated under reduced pressure to give gold
Honeysuckle flower extract.
8. preparation method according to claim 6, it is characterised in that the temperature of the bark of official magnolia is extracted with 30-90% ethanol solutions
For 30-100 DEG C, each extraction time is 1-3h.
9. preparation method according to claim 7, it is characterised in that the temperature of honeysuckle is extracted with 30-90% ethanol solutions
Spend for 30-100 DEG C, each extraction time is 1-3h.
10. application of the anti-inflammatory spray in oral cavity in terms of mouth disease is treated described in claim any one of 1-4.
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| CN201710466717.9A CN107158120A (en) | 2017-06-19 | 2017-06-19 | Oral cavity anti-inflammatory spray, preparation method and application |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201710466717.9A CN107158120A (en) | 2017-06-19 | 2017-06-19 | Oral cavity anti-inflammatory spray, preparation method and application |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111358739A (en) * | 2020-04-30 | 2020-07-03 | 云南风联科技有限公司 | Plant apple-flavored oral atomized liquid and preparation method thereof |
| CN111587939A (en) * | 2020-06-10 | 2020-08-28 | 陈滢钰 | Preparation method of compound cajeput health-care tea beverage |
| CN114522191A (en) * | 2022-01-10 | 2022-05-24 | 湖北恩施州山源道实业有限公司 | Composition containing pteris multifida essential oil as well as preparation method and application thereof |
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| CN101181548A (en) * | 2007-12-07 | 2008-05-21 | 北京未名宝生物科技有限公司 | Medicinal or health care composition containing natural antimicrobials |
| CN103271859A (en) * | 2013-06-09 | 2013-09-04 | 广西奥奇丽股份有限公司 | Chinese herbal medicine toothpaste containing pseudo-ginseng saponin and honeysuckle extract |
| CN105125690A (en) * | 2015-09-23 | 2015-12-09 | 北京水木中天植物科学研究院 | Oral anti-inflammation spray |
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- 2017-06-19 CN CN201710466717.9A patent/CN107158120A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101181548A (en) * | 2007-12-07 | 2008-05-21 | 北京未名宝生物科技有限公司 | Medicinal or health care composition containing natural antimicrobials |
| CN103271859A (en) * | 2013-06-09 | 2013-09-04 | 广西奥奇丽股份有限公司 | Chinese herbal medicine toothpaste containing pseudo-ginseng saponin and honeysuckle extract |
| CN105125690A (en) * | 2015-09-23 | 2015-12-09 | 北京水木中天植物科学研究院 | Oral anti-inflammation spray |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN111358739A (en) * | 2020-04-30 | 2020-07-03 | 云南风联科技有限公司 | Plant apple-flavored oral atomized liquid and preparation method thereof |
| CN111587939A (en) * | 2020-06-10 | 2020-08-28 | 陈滢钰 | Preparation method of compound cajeput health-care tea beverage |
| CN114522191A (en) * | 2022-01-10 | 2022-05-24 | 湖北恩施州山源道实业有限公司 | Composition containing pteris multifida essential oil as well as preparation method and application thereof |
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Application publication date: 20170915 |