CN114886791A - Bubble type sterilization and bacteriostasis mouth wash and preparation method thereof - Google Patents
Bubble type sterilization and bacteriostasis mouth wash and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a gasThe bubble type sterilization and bacteriostasis mouthwash and the preparation method thereof comprise the following components in percentage by weight: water, the balance; 2-5% of glycerin, 0.01-0.05% of pH regulator, 2-11% of flavoring agent, 0.01-0.1% of mint extract, 1-10% of hydrogenated castor oil and 0.01-0.1% of domiphen bromide; introducing CO into collutory 2 ,CO 2 The filling volume of the mouth wash is 1 to 4 times of the volume of the mouth wash. The mouthwash provided by the invention has high sterilization and bacteriostasis efficiency, is cool and comfortable, freshes the oral cavity, has the mouthfeel of soda water, and is novel and unique; meanwhile, the preparation method is simple, the operation is simple and convenient, and the industrialization is easy to realize.
Description
Technical Field
The invention relates to the technical field of oral care products, in particular to a bubble type sterilization and bacteriostasis mouthwash and a preparation method thereof.
Background
Oral cleaning in addition to the conventional use of toothpastes and toothbrushes for brushing teeth, more and more oral cleaning products have been developed, such as toothpowders, mouthwashes, chewing gums, and the like. Of these, mouthwashes are a relatively popular product. The mouthwash is liquid, and is generally filled with components for sterilization and bacteriostasis, and also contains a surfactant, a flavoring agent, a pH regulator, a preservative or other functional components. The mouthwash is convenient to use and is very suitable for being used outdoors. The mouth wash on the market has the effects of refreshing breath, relieving halitosis, diminishing inflammation, relieving pain, treating canker sores and the like besides the basic bactericidal and bacteriostatic effects, but the increased effects are not particularly good. In addition, the existing mouthwash is only a conventional liquid product, has no unique using mouthfeel, and is difficult to stand out from a plurality of products. Therefore, the mouthwash which has a unique taste, and is good in sterilization and bacteriostasis effects, and can remove halitosis and cure the dental ulcer has a good market prospect.
Disclosure of Invention
In order to overcome the defects of the prior art, the invention aims to provide the bubble type sterilization and bacteriostasis mouthwash which has high sterilization and bacteriostasis efficiency, is cool and comfortable and freshes the oral cavity; also has the taste of soda water, and is novel and unique.
The invention also aims to provide a preparation method of the bubble type sterilizing and bacteriostatic mouth wash, which is simple in process.
One of the purposes of the invention is realized by adopting the following technical scheme:
a bubble type sterilization and bacteriostasis mouthwash comprises the following components in percentage by weight: water, the rest; 2-5% of glycerin, 0.01-0.05% of pH regulator, 2-11% of flavoring agent, 0.01-0.1% of mint extract, 1-10% of hydrogenated castor oil and 0.01-0.1% of domiphen bromide; the mouthwash is filled with CO 2 ,CO 2 The filling volume of (a) is 1-4 times of the volume of the mouthwash.
The bubble type mouthwash provided by the invention has the main sterilization and bacteriostasis component of domiphen bromide, the bacteriostasis rates of the mouthwash on Escherichia coli, staphylococcus aureus and Candida albicans reach more than 99%, the bacteriostasis rate on Escherichia coli reaches more than 45%,The sterilization rate of the antibacterial agent on staphylococcus aureus reaches more than 30 percent, and the sterilization rate of the antibacterial agent on candida albicans reaches more than 99 percent. The main component of the mint extract is menthol, which can refresh the mouth, cool and relieve itching, and can also diminish inflammation and ease pain, and promote the healing of oral mucosa inflammation, oral ulcer and the like. The flavoring agent can adjust the mouth feel of the mouthwash, so that the mouth feel of the mouthwash is better. The glycerin and the hydrogenated castor oil play a role in solubilization and can promote the dissolution and mixing of the rest components in the formula; the glycerin also has the function of moisturizing, and the hydrogenated castor oil can also enhance the stability of the formula and avoid the phenomena of layering, precipitation, scum and the like. In addition, the mouthwash is greatly highlighted by CO filling 2 When in use, the mouth wash has the taste of soda water in the oral cavity, the package is opened, and the mouth wash, CO in the mouth wash and the mouth wash are poured into the oral cavity 2 The oral carbonated drink is unique and novel due to the separation and the taste; and, CO 2 The release, the bubble movement drives the domiphen bromide, the mint extract and other components to move in the cavity, the contact and the penetration between the domiphen bromide, the mint extract and other components and the oral mucosa and the teeth are promoted, the antibacterial and bactericidal rate is improved, and the oral cavity is refreshed; CO2 2 The heat in the oral cavity can be taken away by releasing, so that the oral cavity is cool and comfortable; at the same time, CO 2 The release can set off the mint flavor of the mint extract, so that the mint is more cool.
To prevent CO in mouthwash before use 2 The separation is realized, when the discharge tank is filled, the small tank is preferably adopted, the tank capacity is the best disposable dosage, thus ensuring that a user has the best soda water taste and can also use CO when the mouthwash is used 2 The above-mentioned effects brought by precipitation are best exerted. The mouthwash of the invention is filled with CO 2 The product is acidic, and can be used for rinsing with clear water after the mouthwash is used for avoiding the corrosion to teeth. But the gargle can be used without rinsing with clear water, and the use amount is small, the use time is not long, and the teeth can not be damaged.
Furthermore, the bubble type bactericidal and bacteriostatic mouth wash also comprises 0.05-0.2% of scutellaria baicalensis extract and/or 0.01-0.1% of dragon's blood extract. The astragalus extract can clear stagnated fire, improve halitosis, and simultaneously improve the bacteriostatic effect of the mouthwash, especially the inhibitory effect on candida albicans, and the astragalus extract is also beneficial to regulating the balance of oral flora. The sanguis Draxonis extract has effects of relieving pain, stopping bleeding, promoting skin mucosa repair, and accelerating oral ulcer, and has inhibiting and killing common pathogenic bacteria in oral cavity such as Staphylococcus aureus and Staphylococcus albus.
Further, the weight ratio of the mint extract, the scutellaria baicalensis extract and the dragon's blood extract is 1: (1-3): (0.5-1.5), more preferably 1: 2: 1, in the proportion range, the mouth wash has better taste, can also improve halitosis and promote the healing of oral ulcer and the like.
Furthermore, the bubble type sterilizing and bacteriostatic mouth wash also comprises 0.1-0.5% of essence, 0.01-0.2% of first preservative and 0.1-0.8% of second preservative.
Further, the pH adjusting agent includes citric acid; the flavoring agent comprises one or any combination of sorbitol, saccharin sodium and xylitol; the first preservative comprises methylparaben; the second preservative comprises potassium sorbate.
Further, the bubble type sterilizing and bacteriostatic mouth wash comprises the following components in percentage by weight: water, the balance; 2-5% of glycerol, 0.01-0.05% of citric acid, 2-10% of sorbitol, 0.01-0.1% of saccharin sodium, 0.1-0.5% of xylitol and 0.01-0.2% of methylparaben; 0.01-0.1% of mint extract, 0.05-0.2% of scutellaria baicalensis extract, 0.01-0.1% of dragon's blood extract, 1-10% of hydrogenated castor oil, 0.01-0.1% of domiphen bromide, 0.1-0.5% of essence and 0.1-0.8% of potassium sorbate; the mouthwash is filled with CO 2 ,CO 2 Is 2-3 times of the mouthwash volume.
Further, the bubble type sterilizing and bacteriostatic mouth wash comprises the following components in percentage by weight: water, the balance; 3-4% of glycerin, 0.02-0.04% of citric acid, 3-8% of sorbitol, 0.05-0.1% of saccharin sodium, 0.2-0.4% of xylitol and 0.1-0.2% of methyl hydroxybenzoate; 0.05-0.1% of mint extract, 0.1-0.2% of scutellaria baicalensis extract, 0.05-0.1% of dragon's blood extract, 3-8% of hydrogenated castor oil, 0.03-0.1% of domiphen bromide, 0.1-0.3% of essence and 0.1-0.5% of potassium sorbate; the mouthwashIs filled with CO 2 ,CO 2 Is 2-3 times of the mouthwash volume.
The second purpose of the invention is realized by adopting the following technical scheme:
a preparation method of bubble type sterilizing and bacteriostatic mouth wash comprises the following steps:
a first mixing step: mixing water, glycerol, a pH regulator and a flavoring agent according to a formula amount, adding the first preservative if the formula also comprises the first preservative, heating, stirring at constant temperature until the materials are completely dissolved, and cooling to obtain a first mixture;
a second mixing step: adding the formula amount of mint extract, hydrogenated castor oil and domiphen bromide into the first mixture, if the formula also comprises scutellaria baicalensis extract, dragon's blood extract, essence and a second preservative, adding the mixture together, and then uniformly stirring to obtain a second mixture;
and (3) inflating: charging CO into the second mixture 2 ,CO 2 The filling volume of the mouth wash is 1-4 times of the volume of the mouth wash, and the mouth wash is detected and discharged.
Compared with the prior art, the invention has the beneficial effects that:
(1) the bubble type sterilization and bacteriostasis mouth wash provided by the invention has the bacteriostasis rates of over 99 percent on Escherichia coli, staphylococcus aureus and Candida albicans, over 45 percent on Escherichia coli, over 30 percent on Staphylococcus aureus and over 99 percent on Candida albicans. Meanwhile, the oral liquid can cool, relieve itching, refresh the oral cavity, resist inflammation and pain, and promote the healing of oral mucosa inflammation, oral ulcer and the like. The product has the taste of soda water when in use, and is unique and novel; and, CO 2 The release and bubble movement drives the domiphen bromide, the mint extract and other components to move in the cavity, so that the contact and the penetration between the domiphen bromide, the mint extract and other components and the oral mucosa and teeth are promoted, the antibacterial and bactericidal rate is improved, and the oral cavity is refreshed.
(2) The preparation method of the bubble type sterilization and bacteriostasis mouth wash provided by the invention has the advantages of simple process and convenient operation, and is beneficial to realizing industrial production.
Detailed Description
The present invention is further described below with reference to specific embodiments, and it should be noted that, without conflict, any combination between the embodiments or technical features described below may form a new embodiment.
Examples 1 to 3
The embodiment of the invention provides bubble type sterilization and bacteriostasis mouth wash which is prepared by water, glycerin, citric acid, sorbitol, saccharin sodium, xylitol, methyl hydroxybenzoate, mint extract, scutellaria baicalensis extract, dragon's blood extract, CO-40 hydrogenated castor oil, domiphen bromide, essence and potassium sorbate, and is filled with CO 1-4 times of the volume of the mouth wash 2 . In an embodiment of the invention, the mint extract is menthol. The specific components are shown in Table 1.
TABLE 1 bubble mouthwash formulations of examples 1-3
The bubble-type mouthwashes provided in examples 1-3 were prepared as follows:
adding water, glycerol, citric acid, sorbitol, saccharin sodium, xylitol and methyl hydroxybenzoate in a formula ratio into a vacuum emulsifying pot, heating to 90 ℃, stirring at constant temperature for 1 hour until the materials are completely dissolved, and cooling to 45 ℃ to obtain a first mixture;
adding the mint extract, the scutellaria baicalensis extract, the dragon's blood extract, the CO-40 hydrogenated castor oil, the domiphen bromide, the essence and the potassium sorbate into the first mixture according to the formula ratio, and then uniformly stirring to obtain a second mixture;
charging CO into the second mixture 2 ,CO 2 The filling volume of (1) or (2) or (4) times of the mouthwash volume of (3), and then the detection and discharge are carried out.
Comparative example 1
Comparative example 1 differs from example 1 in that no CO charge was applied 2 The gas was the same as in example 1.
Comparative example 2
Comparative example 2 is different from example 1 in that no astragalus extract was added, and the rest is the same as example 1.
Comparative example 3
Comparative example 3 is different from example 1 in that the dragon's blood extract is not added, and is otherwise the same as example 1.
Comparative example 4
Comparative example 4 is different from example 1 in that the mint extract, the scutellaria extract and the dragon's blood extract were used in amounts of 0.1%, 0.05% and 0.2%, respectively, in a weight ratio of 1: 0.5: 2, exceeding 1: (1-5): (0.5-1.5).
Effect testing
First, bacteriostasis test
The samples of the mouthwashes of examples 1-3 were tested for bacteriostasis according to the test and analytical method of GB15979-2002, and the results are shown in Table 2 below.
Table 2 bacteriostatic test result recording table
As can be seen from the records in Table 2, the mouthwash of examples 1-3 all showed 99% or more of inhibition of Escherichia coli, Staphylococcus aureus, and Candida albicans.
Second, sterilization test
Samples of the mouthwashes of examples 1-3 were subjected to a bactericidal test according to GB15979-2002 and the results are shown in Table 3 below.
TABLE 3 antibacterial experiment test results recording table
As can be seen from the records in table 3, the mouthwash according to the embodiment of the present invention has a sterilization rate of 45% or more for escherichia coli, 30% or more for staphylococcus aureus, and 99% or more for candida albicans.
Third, test on volunteers
70 volunteers with halitosis and canker sore were recruited, divided into 7 groups on average, 10 persons per group were tried with the mouthwashes of examples 1-3 and comparative examples 1-4, respectively, and all mouthwashes were packaged in small bottles of 100ml before use. The volunteers were started in the morning, opened with mouthwash, tried immediately, held in the mouth for 2 minutes and then spitted out for 10 consecutive days, and were not using any product with similar efficacy during the trial of mouthwash. The trial effect of the volunteers was recorded as shown in table 4 below.
Halitosis
And (3) curing: after the oral liquid is used, the halitosis completely disappears, and the halitosis does not relapse after continuous observation for 7 days;
the effect is shown: after the oral liquid is used, the halitosis symptom is obviously relieved;
and (4) invalidation: after the oral liquid is used, the symptoms of halitosis are not reduced or are aggravated.
Oral ulcer
And (3) curing: after the oral ulcer powder is used, the oral ulcer symptoms completely disappear, and the oral ulcer powder does not relapse after continuous observation for 7 days;
the effect is shown: the oral ulcer symptom is obviously relieved after the oral ulcer medicament is used;
and (4) invalidation: the oral ulcer symptoms are not reduced or aggravated after the oral ulcer is used.
Mouthfeel feedback (score system, full score 10, higher score, higher evaluation, result of reorganization mean)
Index 1: the soft drink has obvious soda feeling, and is unique and novel;
index 2: good effect, high taste acceptance and continuous use.
Table 4 trial result recording table
As can be seen from the record in table 4, the bubble-type mouthwash provided by the present invention provided by the embodiment of the present invention has the effects of refreshing, relieving itching, removing halitosis, freshening oral cavity, resisting inflammation, alleviating pain, and promoting healing of oral mucosa inflammation, oral ulcer and the like, and the carbonated drink has a distinct, unique and novel taste.
The mouth wash provided by the embodiment of the invention is filled with CO2, when the mouth wash is used, the mouth wash has the mouth feel of soda water in the oral cavity, the mouth wash is poured into the oral cavity after the package is opened, and CO2 in the mouth wash is separated out, so that the mouth wash is unique and novel; and CO2 is released, and the bubble movement drives the domiphen bromide, the mint extract, the astragalus extract, the dragon's blood extract and other components to move in the cavity, so that the contact and the penetration between the domiphen bromide, the mint extract, the astragalus extract, the dragon's blood extract and the like are promoted, the antibacterial and bactericidal rate is improved, the oral cavity is refreshed, the oral mucosa is repaired, and the healing of the oral ulcer is promoted; meanwhile, CO2 is released, so that the heat of the oral cavity can be taken away, and the oral cavity is cool and comfortable; and CO2 releases a mint flavor that can support mint extracts, making mint cooling more pleasant.
Comparative example 1 no carbon dioxide was introduced, the mouth wash did not have the unique taste of carbonated drink, and the effective rate for halitosis and oral ulcer was reduced compared to the examples.
Compared with the prior art, the astragalus extract is not added, so that the effect of clearing stagnated fire cannot be achieved, the effective rate on halitosis is greatly reduced, the healing time of oral ulcer is relatively prolonged, and the effective rate is reduced.
Comparative example 3 no dragon's blood extract is added, the effective rate of halitosis is reduced, the repair effect on skin mucosa is greatly reduced, and the effective rate of oral ulcer is greatly reduced.
Comparative example 4 the amount of mint extract, scutellaria extract and dragon's blood extract exceeded 1: (1-5): (0.5-1.5), the taste was poor and the acceptance by the test subjects was low.
During the trial period, part of oral ulcer volunteers react, and when the oral cavity is just contacted with the mouthwash, the part of the oral ulcer has a prick pain feeling, but the prick pain feeling disappears quickly and is within an acceptable range. Since the canker sore portion itself is sensitive, it may feel a bit painful even when it is exposed to fresh water.
The above embodiments are only preferred embodiments of the present invention, and the protection scope of the present invention is not limited thereby, and any insubstantial changes and substitutions made by those skilled in the art based on the present invention are within the protection scope of the present invention.
Claims (10)
1. The bubble type sterilizing and bacteriostatic mouth wash is characterized by comprising the following components in percentage by weight: water, the balance; 2-5% of glycerin, 0.01-0.05% of pH regulator, 2-11% of flavoring agent, 0.01-0.1% of mint extract, 1-10% of hydrogenated castor oil and 0.01-0.1% of domiphen bromide; the mouthwash is filled with CO 2 ,CO 2 The filling volume of (a) is 1-4 times of the volume of the mouthwash.
2. The bubble type mouthwash for sterilization and bacteriostasis according to claim 1, further comprising 0.05-0.2% of scutellaria baicalensis extract and/or 0.01-0.1% of dragon's blood extract.
3. The bubble type bactericidal bacteriostatic mouth wash according to claim 2, wherein the weight ratio of the mint extract, the scutellaria baicalensis extract and the dragon's blood extract is 1: (1-5): (0.5-1.5).
4. The bubble type bactericidal bacteriostatic mouth wash according to claim 1, further comprising 0.1-0.5% of essence, 0.01-0.2% of first preservative and 0.1-0.8% of second preservative.
5. The bubble-type mouthwash according to claim 4, wherein the pH adjuster comprises citric acid; the flavoring agent comprises one or any combination of sorbitol, saccharin sodium and xylitol; the first preservative comprises methylparaben; the second preservative comprises potassium sorbate.
6. The bubble type sterilizing and bacteriostatic mouth wash as claimed in claim 1, which comprises the following components in percentage by weight: water, the balance; 2-5% of glycerin, 0.01-0.05% of citric acid, 2-10% of sorbitol, 0.01-0.1% of saccharin sodium, 0.1-0.5% of xylitol and 0.01-0.2% of methyl hydroxybenzoate; 0.01-0.1% of mint extract, 0.05-0.2% of scutellaria baicalensis extract, 0.01-0.1% of dragon's blood extract, 1-10% of hydrogenated castor oil, 0.01-0.1% of domiphen bromide, 0.1-0.5% of essence and 0.1-0.8% of potassium sorbate; the mouthwash is filled with CO 2 ,CO 2 The filling volume of (a) is 2-3 times of the volume of the mouthwash.
7. The bubble type sterilizing and bacteriostatic mouth wash according to claim 1, which comprises the following components in percentage by weight: water, the balance; 3-4% of glycerin, 0.02-0.04% of citric acid, 3-8% of sorbitol, 0.05-0.1% of saccharin sodium, 0.2-0.4% of xylitol and 0.1-0.2% of methyl hydroxybenzoate; 0.05-0.1% of mint extract, 0.1-0.2% of scutellaria baicalensis extract, 0.05-0.1% of dragon's blood extract, 3-8% of hydrogenated castor oil, 0.03-0.1% of domiphen bromide, 0.1-0.3% of essence and 0.1-0.5% of potassium sorbate; the mouthwash is filled with CO 2 ,CO 2 The filling volume of (a) is 2-3 times of the volume of the mouthwash.
8. The bubble type sterilizing and bacteriostatic mouth wash as claimed in claim 1, which comprises the following components in percentage by weight: water, the balance; 3% of glycerin, 0.03% of citric acid, 6% of sorbitol, 0.05% of saccharin sodium, 0.3% of xylitol and 0.1% of methyl hydroxybenzoate; 0.05% of mint extract, 0.1% of scutellaria extract, 0.05% of dragon's blood extract, 6% of hydrogenated castor oil, 0.05% of domiphen bromide, 0.3% of essence and 0.5% of potassium sorbate; the mouthwash is filled with CO 2 ,CO 2 Is 2.5 times the volume of the mouthwash.
9. A method for preparing the bubble type bactericidal bacteriostatic mouth wash according to any one of claims 1 to 8, which comprises the following steps:
a first mixing step: mixing water, glycerol, a pH regulator and a flavoring agent according to a formula amount, adding the first preservative if the formula also comprises the first preservative, heating, stirring at constant temperature until the materials are completely dissolved, and cooling to obtain a first mixture;
a second mixing step: adding the formula amount of mint extract, hydrogenated castor oil and domiphen bromide into the first mixture, if the formula also comprises scutellaria baicalensis extract, dragon's blood extract, essence and a second preservative, adding the mixture together, and then uniformly stirring to obtain a second mixture;
and (3) inflating: charging CO into the second mixture 2 ,CO 2 The filling volume of the mouth wash is 1-4 times of the volume of the mouth wash, and the mouth wash is detected and discharged.
10. The preparation method of the bubble type sterilizing and bacteriostatic mouth wash according to claim 9, which comprises the following steps:
a first mixing step: mixing water, glycerol, pH regulator and flavoring agent according to formula amount, adding first antiseptic if the formula also comprises, heating to 85-95 deg.C, stirring at constant temperature for 0.8-1.5 hr until the materials are completely dissolved, and cooling to 50-40 deg.C to obtain first mixture;
a second mixing step: adding the mint extract, the hydrogenated castor oil and the domiphen bromide in the formula amount into the first mixture, if the formula also comprises the scutellaria baicalensis extract, the dragon's blood extract, the essence and the second preservative, then adding the two together, and uniformly stirring to obtain a second mixture;
and (3) inflating: charging CO into the second mixture 2 ,CO 2 The filling volume of the mouth wash is 2-3 times of the volume of the mouth wash, and the mouth wash is detected and discharged.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115804747A (en) * | 2022-12-14 | 2023-03-17 | 吉林省富生医疗器械有限公司 | Antibacterial mouth wash and preparation method thereof |
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| EP2111841A2 (en) * | 2008-04-25 | 2009-10-28 | Henkel AG & Co. KGaA | Effervescent mouthwash preparations |
| CN101647768A (en) * | 2009-09-08 | 2010-02-17 | 上海大学 | Process for preparing Chinese herbal medicine toothpaste containing dragon's blood extract |
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| CN1650989A (en) * | 2004-12-15 | 2005-08-10 | 胡少勇 | Chinese medicine oral cavity adherent emplastrum and its preparation method |
| EP2111841A2 (en) * | 2008-04-25 | 2009-10-28 | Henkel AG & Co. KGaA | Effervescent mouthwash preparations |
| CN101647768A (en) * | 2009-09-08 | 2010-02-17 | 上海大学 | Process for preparing Chinese herbal medicine toothpaste containing dragon's blood extract |
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