CN101647768A - Process for preparing Chinese herbal medicine toothpaste containing dragon's blood extract - Google Patents
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- CN101647768A CN101647768A CN200910195306A CN200910195306A CN101647768A CN 101647768 A CN101647768 A CN 101647768A CN 200910195306 A CN200910195306 A CN 200910195306A CN 200910195306 A CN200910195306 A CN 200910195306A CN 101647768 A CN101647768 A CN 101647768A
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Abstract
The invention relates to Chinese herbal medicine toothpaste containing a dragon's blood extract and a preparation method thereof, belonging to the technical field of preparation processes of Chinese herbal medicine toothpaste of articles for daily life. The Chinese herbal medicine toothpaste containing the dragon's blood extract is characterized by comprising the following components in percentageby weight: 40-46 percent of calcium carbonate, 6-10 percent of sodium bicarbonate, 0.7-0.8 percent of carrageenan, 0.7-0.8 percent of sodium carboxymethylcellulose, 12-14 percent of glycerol, 14-16 percent of sorbitol, 2-3 percent of sldium lauryl sulfate, 0.1-0.3 percent of saccharin, 0-0.2 percent of potassium sorbate, 1-1.5 percent of strawberry essence, 0.25-0.5 percent of dragon's blood extract and the balance of water. Because the toothpaste contains a dragon's blood active component, the toothpaste has the effects of preventing oral ulcer, preventing oral diseases caused by candida albicans infection besides the function of cleaning teeth.
Description
Technical field
The present invention relates to a kind of Chinese herbal toothpaste that contains Sanguis Draxonis extract and preparation method thereof, belong to daily living article Chinese herbal toothpaste fabricating technology field.
Background technology
In recent years, the wind of " healthy harmonious, back to nature " in vogue on the market, people more and more value the medical care effect of " natural component " in the commodity.In the toothpaste industry, people more and more like Chinese herbal toothpaste.
" panacea of invigorating blood circulation "--Sanguis Draxonis contains various active effective ingredient such as flavonoid, plant defense element, phenols and cardiac glycoside, has that blood circulation promoting and blood stasis dispelling, Repercusion analgesia, hemostasis are enriched blood, the effect of blood sugar lowering.Modern medicine study proves, Sanguis Draxonis also has very strong antibacterium, antifungal, antioxidation, anti-inflammatory, antiulcer, promoting healing, short convergence, improve the body microcirculation, adjust the body metabolism, improve multidirectional regulating action such as immunity of organisms.Therefore, can be used as a kind of effective ingredient adds in the toothpaste.
Dental caries is a kind of in the world the most common oral disease, and it is almost ubiquitous.The mankind drop into a huge sum of money aspect this treatment of diseases and the prevention.International medical circle of oral cavity has proved that fluoride can effectively prevent decayed tooth, and still, it is excessive that fluorine uses, and will cause fluorosis, gently then forms dental fluorosis, and is heavy then cause skeletal fluorosis, so the potential hazard of fluorine can not be ignored.Therefore, seek a kind of suitable safe, can effectively nurse one's health the emphasis that the equilibrated anticariogenic agent of oral cavity flora becomes dental caries research.
Dental caries is one of human modal infectious disease.From ecological angle, dental caries is that normal flora becomes due to the conditioned pathogen owing to the oral cavity disturbed ecological balance.
Candida albicans claims saccharomyces albicans again, is to parasitize intraoral a kind of yeast-like fungi, has the physiological feature of cariogenic bacteria: can attach to facing with other antibacterial copolymerization and have very strong product acidity and acid resistance.For a long time, main cariogenic bacteria such as Streptococcus mutans is occupied an leading position in the research of dental caries.Have a lot of reports to show in recent years, Candida albicans is also relevant with dental caries.
Samaranayake cultivates 48h to the Candida albicans aerobic in the culture fluid that has added saccharide, its pH curve is " S " deformationization, and pH value drops to 3.5 from 7; When anaerobism is cultivated, there is not the variation of pH.Measure the main acid ingredient in the culture fluid, acetate, formates, pyruvate and propionate are wherein arranged.Candida albicans can cause hydroxyapatite (hydroxyapatite, HA) demineralization, and approximately be 20 times of Streptococcus mutans to the solvability of HA.Candida albicans and Streptococcus mutans almost all do not have the demineralization ability to HA at the cultivation initial stage (in the 24h), all need abundant growth just can cause the demineralization of HA.
Kaminishi etc. think that Candida albicans utilizes its a kind of Proteolytic enzyme enzymatic degradation dentin collagen structure that produces, thereby participate in developing of carious dentin.
Except that dental caries, oral ulcer also is one of recurrent oral problem.Oral ulcer claims ulcerative stomatitis again, is a kind of common oral disease, due to virus or antibacterial.General normal have streptococcus, staphylococcus aureus, bacillus pyocyaneus and escherichia coli to cause.When reducing, Abwehrkraft des Koepers can cause the generation of oral ulcer.Research toothpaste has considerable meaning to staphylococcus aureus, colibacillary inhibitory action.
Summary of the invention
The purpose of this invention is to provide a kind of Chinese herbal toothpaste that contains Sanguis Draxonis extract and preparation method thereof.
A kind of Chinese herbal toothpaste that contains Sanguis Draxonis extract of the present invention is characterized in that having following constituent and weight percentage thereof:
Calcium carbonate 40%～46% sodium laurylsulfate 2%～3%
Sodium bicarbonate 6%～10% glucide 0.1%～0.3%
Carrageenan 0.7%～0.8% potassium sorbate 0%～0.2%
Sodium carboxymethyl cellulose 0.7%～0.8% strawberry essence 1%～1.5%
Glycerol 12%～14% Sanguis Draxonis extract 0.25%～0.5%
Sorbitol 14%～16% water surplus
A kind of preparation method that contains the Chinese herbal toothpaste of Sanguis Draxonis extract of the present invention is characterized in that having following process and step:
A. carry out weigh batching by above-mentioned prescription: at first sodium carboxymethyl cellulose, carrageenan are put in moistening dispersion in glycerol, the sorbitol; Add glucide water then and stir; Its ageing after 24 hours, is added sodium laurylsulfate and potassium sorbate, stir;
B. add then and use the dissolved Sanguis Draxonis extract of essence in advance; Sanguis Draxonis extract is got by prepared beforehand, includes: Sanguis Draxonis petroleum ether raffinate and Sanguis Draxonis ethyl acetate cold extraction thing, optional a kind of among both;
C. continue to stir, make its mix homogeneously, and then add sodium bicarbonate, calcium carbonate, stir; After the ageing 12 hours, it is fully ground, and vacuum outgas, tubulature then promptly gets the product Chinese herbal toothpaste.
Described prepared beforehand and Sanguis Draxonis extract, promptly the preparation process of Sanguis Draxonis petroleum ether raffinate and Sanguis Draxonis ethyl acetate cold extraction thing is as follows:
A. the preparation of Sanguis Draxonis petroleum ether raffinate: the petroleum ether of the former powder of Sanguis Draxonis and its 10 times of weight is placed in the Soxhlet extractor,, raffinate is taken out, volatilize behind the solvent promptly 50 degrees centigrade of drying and crushing 60 to 70 degrees centigrade of following extractings 2 to 4 hours;
B. the preparation of Sanguis Draxonis ethyl acetate cold extraction thing: the ethyl acetate solution of above-mentioned gained petroleum ether raffinate and its 5 times of weight at room temperature leached spend the night, leaching liquid at 40 to 50 degrees centigrade of following rotary evaporations, is volatilized behind the solvent 50 degrees centigrade of drying and crushing promptly.
Among the present invention, calcium carbonate is a lotion of toothpaste substrate, and the sodium bicarbonate of adding can increase the dissolubility of Sanguis Draxonis extract in substrate on the one hand; On the other hand, because the effective cleaning oral cavity of sodium bicarbonate itself, counteract oral malodour can more effectively be nursed the oral cavity.
The antisepsis that Sanguis Draxonis itself has in the formulation of tooth-paste of the present invention, is added with Sanguis Draxonis extract, owing to can not add or few adding preservative agent potassium sorbate.
The Chinese herbal toothpaste that the inventive method makes, owing to contain the Chinese herbal medicine dragon's blood active component of hemostasis and anti-inflammation, antibacterium, antifungal, antiulcer, blood circulation promoting and blood stasis dispelling, Repercusion analgesia, so have certain medical care effect to preventing and treating dental caries with oral diseases such as preventing oral ulcer, can improve people's oral health level.
The specific embodiment
After now specific embodiments of the invention being described in.
The percentage ratio of each ingredients constitute toothpaste total composition weight of embodiment one described toothpaste is:
Calcium carbonate 40 sodium laurylsulfates 2
Sodium bicarbonate 10 glucide 0.1
Carrageenan 0.8 potassium sorbate 0.2
Carboxymethyl cellulose sodium 0.8 strawberry essence 1.4
Glycerol 12 Sanguis Draxonis petroleum ether raffinate 0.25
Sorbitol 14 water surplus
Its step of preparation process is:
1. carboxymethyl cellulose sodium, carrageenan are put in moistening dispersion in glycerol, the sorbitol;
2. adding glucide water stirs;
3. ageing is 24 hours;
4. add sodium laurylsulfate, potassium sorbate stirs;
5. add and use the dissolved Sanguis Draxonis petroleum ether of essence raffinate in advance, stir;
6. add sodium bicarbonate, calcium carbonate stirs;
7. ageing is 12 hours;
8. grind fully;
9. vacuum outgas;
10. tubulature.
The percentage ratio of each ingredients constitute toothpaste total composition weight of embodiment two described toothpaste is:
Calcium carbonate 40 sodium laurylsulfates 2
Sodium bicarbonate 10 glucide 0.1
Carrageenan 0.8 potassium sorbate 0.2
Carboxymethyl cellulose sodium 0.8 strawberry essence 1.4
Glycerol 12 Sanguis Draxonis ethyl acetate cold extraction things 0.25
Sorbitol 14 water surplus
Among its preparation technology, remove step 5 and use the dissolved Sanguis Draxonis ethyl acetate of essence cold extraction thing in advance for adding, outside stirring, all the other are with embodiment one.
The percentage ratio of each ingredients constitute toothpaste total composition weight of embodiment three described toothpaste is:
Calcium carbonate 40 sodium laurylsulfates 2
Sodium bicarbonate 10 glucide 0.1
Carrageenan 0.8 strawberry essence 1.4
Carboxymethyl cellulose sodium 0.8 Sanguis Draxonis petroleum ether raffinate 0.25
Glycerol 12 water surplus
Sorbitol 14
Its step of preparation process is:
1. carboxymethyl cellulose sodium, carrageenan are put in moistening dispersion in glycerol, the sorbitol;
2. adding glucide water stirs;
3. ageing is 24 hours;
4. adding sodium laurylsulfate stirs;
5. add and use the dissolved Sanguis Draxonis petroleum ether of essence raffinate in advance, stir;
6. add sodium bicarbonate, calcium carbonate stirs;
7. ageing is 12 hours;
8. grind fully;
9. vacuum outgas;
10. tubulature.
The percentage ratio of each ingredients constitute toothpaste total composition weight of embodiment four described toothpaste is:
Calcium carbonate 40 sodium laurylsulfates 2
Sodium bicarbonate 10 glucide 0.1
Carrageenan 0.8 strawberry essence 1.4
Carboxymethyl cellulose sodium 0.8 Sanguis Draxonis ethyl acetate cold extraction thing 0.25
Glycerol 12 water surplus
Sorbitol 14
Among its preparation technology, remove step 5 and use the dissolved Sanguis Draxonis ethyl acetate of essence cold extraction thing in advance for adding, outside stirring, all the other are with embodiment three.
In the foregoing description, the preparation process of described Sanguis Draxonis petroleum ether raffinate and Sanguis Draxonis ethyl acetate cold extraction thing is as described below:
(1) preparation of Sanguis Draxonis petroleum ether raffinate places the petroleum ether of the former powder of Sanguis Draxonis and its 10 times of weight in the Soxhlet extractor, 60 to 70 degrees centigrade of following extractings 2 to 4 hours, raffinate is taken out, and volatilizes behind the solvent 50 degrees centigrade of drying and crushing promptly;
(2) preparation of Sanguis Draxonis ethyl acetate cold extraction thing is at room temperature leached the ethyl acetate solution of above-mentioned gained petroleum ether raffinate and its 5 times of weight and is spent the night, leaching liquid at 40 to 50 degrees centigrade of following rotary evaporations, is volatilized behind the solvent 50 degrees centigrade of drying and crushing promptly.
Chinese herbal toothpaste of the present invention compares with the contrast of " blank toothpaste " and commercially available each Chinese herbal toothpaste.
It is 1.25mg/ml to the oidiomycetic minimal inhibitory concentration of white that the present invention records Sanguis Draxonis by " tube dilution method ".The present invention is to making blank toothpaste by oneself, the Chinese herbal toothpaste that contains Sanguis Draxonis extract (is compared with blank toothpaste, added the petroleum ether raffinate), Radix Notoginseng special effect Chinese toothpaste, the Colgate-Palmolive bee glue tooth paste, China's Chinese herbal toothpaste, the Colgate-Palmolive herbaceous toothpaste, the Crest herbaceous toothpaste, find in the bacteriostatic experiment of Black people's tea times toothpaste that each toothpaste sorts from big to small to the oidiomycetic inhibition strength of white and is respectively: the Colgate-Palmolive bee glue tooth paste, the Chinese herbal toothpaste that contains Sanguis Draxonis extract, the Crest herbaceous toothpaste, China's Chinese herbal toothpaste, make blank toothpaste by oneself, Black people's tea times toothpaste, the Colgate-Palmolive herbaceous toothpaste, Radix Notoginseng special effect Chinese toothpaste.The Chinese herbal toothpaste that contains Sanguis Draxonis extract is only second to the Colgate-Palmolive bee glue tooth paste for the inhibitory action of Candida albicans, illustrates that it is expected to for caries prevention provides new thinking, and becomes a kind of novel anticarious tooth paste; For staphylococcus aureus, contain Sanguis Draxonis extract Chinese herbal toothpaste, to make blank toothpaste, Chinese Chinese herbal toothpaste, Colgate-Palmolive herbaceous toothpaste effect by oneself approaching, slightly be worse than Crest herbaceous toothpaste, Black people's tea times toothpaste, Radix Notoginseng special effect Chinese toothpaste, and the Colgate-Palmolive bee glue tooth paste is the most weak to the staphylococcus aureus inhibitory action in each toothpaste; For escherichia coli, the inhibition effect of each toothpaste is approaching, does not have significant difference on the statistics.In a word, experimental results show that: the Chinese herbal toothpaste that contains Sanguis Draxonis extract all has good inhibitory effect to Candida albicans, staphylococcus aureus and escherichia coli, can be used as antibacterial toothpaste and uses, particularly a kind of novel preventing decayed tooth, anti-oral ulcer toothpaste.
Claims (3)
1. Chinese herbal toothpaste that contains Sanguis Draxonis extract is characterized in that having following constituent and weight percentage thereof:
Calcium carbonate 40%～46% sodium laurylsulfate 2%～3%
Sodium bicarbonate 6%～10% glucide 0.1%～0.3%
Carrageenan 0.7%～0.8% potassium sorbate 0%～0.2%
Sodium carboxymethyl cellulose 0.7%～0.8% strawberry essence 1%～1.5%
Glycerol 12%～14% Sanguis Draxonis extract 0.25%～0.5%
Sorbitol 14%～16% water surplus.
2. preparation method that contains the Chinese herbal toothpaste of Sanguis Draxonis extract is characterized in that having following process and step:
A. carry out weigh batching by above-mentioned prescription: at first sodium carboxymethyl cellulose, carrageenan are put in moistening dispersion in glycerol, the sorbitol; Add glucide water then and stir; Its ageing after 24 hours, is added sodium laurylsulfate and potassium sorbate, stir;
B. add then and use the dissolved Sanguis Draxonis extract of essence in advance; Sanguis Draxonis extract is got by prepared beforehand, includes: Sanguis Draxonis petroleum ether raffinate and Sanguis Draxonis ethyl acetate cold extraction thing, optional a kind of among both;
C. continue to stir, make its mix homogeneously, and then add sodium bicarbonate, calcium carbonate, stir; After the ageing 12 hours, it is fully ground, and vacuum outgas, tubulature then promptly gets the product Chinese herbal toothpaste.
3. a kind of preparation method that contains the Chinese herbal toothpaste of Sanguis Draxonis extract as claimed in claim 2, the Sanguis Draxonis extract that it is characterized in that described prepared beforehand and get, promptly the preparation process of Sanguis Draxonis petroleum ether raffinate and Sanguis Draxonis ethyl acetate cold extraction thing is as follows:
A. the preparation of Sanguis Draxonis petroleum ether raffinate: the petroleum ether of the former powder of Sanguis Draxonis and its 10 times of weight is placed in the Soxhlet extractor,, raffinate is taken out, volatilize behind the solvent promptly 50 degrees centigrade of drying and crushing 60 to 70 degrees centigrade of following extractings 2 to 4 hours;
B. the preparation of Sanguis Draxonis ethyl acetate cold extraction thing: the ethyl acetate solution of above-mentioned gained petroleum ether raffinate and its 5 times of weight at room temperature leached spend the night, leaching liquid at 40 to 50 degrees centigrade of following rotary evaporations, is volatilized behind the solvent 50 degrees centigrade of drying and crushing promptly.
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| CN2009101953066A CN101647768B (en) | 2009-09-08 | 2009-09-08 | Process for preparing Chinese herbal medicine toothpaste containing dragon's blood extract |
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Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102895150A (en) * | 2012-09-29 | 2013-01-30 | 浙江师范大学 | Trichosanthes kirilowii maxim toothpaste |
| CN104382767A (en) * | 2014-10-27 | 2015-03-04 | 周时敏 | Red-medicine toothpaste and making method thereof |
| CN107280982A (en) * | 2017-06-19 | 2017-10-24 | 何家平 | A kind of toothpaste technique |
| CN108096133A (en) * | 2016-11-24 | 2018-06-01 | 云南民族大学 | Mobyneb Resina Draconis toothpaste |
| CN109044933A (en) * | 2018-10-18 | 2018-12-21 | 云南大唐汉方制药股份有限公司 | It is a kind of with preventing and treating Resina Draconis toothpaste of diseases such as canker sore and preparation method thereof |
| CN109758392A (en) * | 2019-01-30 | 2019-05-17 | 河南中医药大学 | A kind of women oral-cavity article that cooperation toothpaste uses |
| CN110559382A (en) * | 2019-10-25 | 2019-12-13 | 北京中医药大学 | preparation method and application of dragon's blood extract |
| US11304888B2 (en) | 2019-04-29 | 2022-04-19 | Sunstar Americas, Inc. | Oral care composition |
| CN114886791A (en) * | 2022-05-09 | 2022-08-12 | 广州市白云区大荣精细化工有限公司 | Bubble type sterilization and bacteriostasis mouth wash and preparation method thereof |
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| CN100384407C (en) * | 2004-12-15 | 2008-04-30 | 胡少勇 | Chinese medicine oral cavity adherent emplastrum and its preparation method |
| CN1872279B (en) * | 2005-06-01 | 2010-05-12 | 江苏中康药物科技有限公司 | Composition of medication for treating ulcer in the oral cavity, and preparation method |
| CN100509029C (en) * | 2006-03-30 | 2009-07-08 | 上海大学 | Preparing process of Chinese medicine dragon's blood flavone extract |
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2009
- 2009-09-08 CN CN2009101953066A patent/CN101647768B/en not_active Expired - Fee Related
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102895150A (en) * | 2012-09-29 | 2013-01-30 | 浙江师范大学 | Trichosanthes kirilowii maxim toothpaste |
| CN104382767A (en) * | 2014-10-27 | 2015-03-04 | 周时敏 | Red-medicine toothpaste and making method thereof |
| CN108096133A (en) * | 2016-11-24 | 2018-06-01 | 云南民族大学 | Mobyneb Resina Draconis toothpaste |
| CN107280982A (en) * | 2017-06-19 | 2017-10-24 | 何家平 | A kind of toothpaste technique |
| CN109044933A (en) * | 2018-10-18 | 2018-12-21 | 云南大唐汉方制药股份有限公司 | It is a kind of with preventing and treating Resina Draconis toothpaste of diseases such as canker sore and preparation method thereof |
| CN109044933B (en) * | 2018-10-18 | 2020-01-21 | 云南大唐汉方制药股份有限公司 | Application of dragon's blood extract in preparing toothpaste for inhibiting dental plaque |
| CN109758392A (en) * | 2019-01-30 | 2019-05-17 | 河南中医药大学 | A kind of women oral-cavity article that cooperation toothpaste uses |
| US11304888B2 (en) | 2019-04-29 | 2022-04-19 | Sunstar Americas, Inc. | Oral care composition |
| CN110559382A (en) * | 2019-10-25 | 2019-12-13 | 北京中医药大学 | preparation method and application of dragon's blood extract |
| CN110559382B (en) * | 2019-10-25 | 2022-04-01 | 北京中医药大学 | Preparation method and application of dragon's blood extract |
| CN114886791A (en) * | 2022-05-09 | 2022-08-12 | 广州市白云区大荣精细化工有限公司 | Bubble type sterilization and bacteriostasis mouth wash and preparation method thereof |
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