CN109044933A - It is a kind of with preventing and treating Resina Draconis toothpaste of diseases such as canker sore and preparation method thereof - Google Patents
It is a kind of with preventing and treating Resina Draconis toothpaste of diseases such as canker sore and preparation method thereof Download PDFInfo
- Publication number
- CN109044933A CN109044933A CN201811213975.7A CN201811213975A CN109044933A CN 109044933 A CN109044933 A CN 109044933A CN 201811213975 A CN201811213975 A CN 201811213975A CN 109044933 A CN109044933 A CN 109044933A
- Authority
- CN
- China
- Prior art keywords
- parts
- essence
- toothpaste
- mentioned
- dragon
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/04—Drugs for disorders of the respiratory system for throat disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Pulmonology (AREA)
- Communicable Diseases (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Diabetes (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Otolaryngology (AREA)
- Hematology (AREA)
- Cosmetics (AREA)
Abstract
The present invention is a kind of with Resina Draconis toothpaste of diseases such as prevention and treatment canker sore and preparation method thereof, it is to be dissolved or dispersed in dragon's blood extract in certain matrix, is prepared into the toothpaste for having good therapeutic effect to canker sore, various focusing depths represented, periodontitis, chronic pharyngitis, mouth syndrome of burning.
Description
Technical field
The present invention is a kind of functional toothpaste, belongs to oral cavity medicine object research and development technology field, and in particular to one kind has pre-
Resina Draconis toothpaste of diseases such as anti-and treatment canker sore and preparation method thereof.
Background technique
Necessity of the toothpaste as daily life, most basic function mainly clean tooth, keep oral health etc.,
And mouth disease includes oral mucosa, decayed tooth, oral cavity anabrosis, bleeding gums, gingivitis, periodontitis, gingival atrophy and cementum
Be lost etc..The health of tooth, it is extremely important to the whole body health of people.According to the report, oral health is bad and general disease, such as heart
There are closely related for popular name for, diabetes and some respiratory diseases.
In recent years, various functional form toothpaste had become the favorite of toothpaste, he is with people's living standard and scientific and technological water
Flat development, people also pursue healthy and simple life style while pursuing high-quality life.
Resina Draconis, Latin literary fame RESINA DRACONIS. are the resin of Liliaceae swordleaf dragon tree.Can activating microcirculation and removing stasis medicinal,
Energy astringing to arrest bleeding again has dual regulation.It is antimycotic, in terms of effect it is stronger, treatment fungal disease, inflammation
Disease etc. curative effect is more excellent.Modern research shows that Resina Draconis other than with function of promoting blood circulation to disperse blood clots, can also improve, body is micro- to be followed
Ring adjusts endocrine, increases internal coagulation factor, have significant anastalsis to bleeding patients, he or a kind of plant defense element,
Has the function of putrefaction-removing granulation-promoting.Resina Draconis is for treatment canker sore, various focusing depths represented, periodontitis, chronic pharyngitis, mouth syndrome of burning
It is significant etc. effective in cure.
Summary of the invention
The present invention provides a kind of with preventing and treating Resina Draconis toothpaste of diseases such as canker sore and preparation method thereof,
It can be used for improving oral hygiene, prevention and treat mouth disease.
Technical solution of the present invention is as follows:
Formula
Each component is by weight: 0.01-2 parts of dragon's blood extract, 10-60 parts of sorb (sugar) alcohol, hydrated silica 4-35
Part, 5-30 parts of glycerol, 0.3-3 parts of laruyl alcohol sodium sulfovinate, 0.01-2 parts of essence, 0.1-2 parts of carragheen, cellulose gum 0.1-2
Part, 0.1-2 parts of titanium dioxide, 0.5-5 parts of dipotassium glycyrrhizinate, 0.1-3 parts of sodium benzoate, 0.2-4 parts of disodium ethylene diamine tetraacetate,
Appropriate amount of water composition.
The essence, it is characterised in that can be orange essence or banana banana or flavoring apple essence or hawthorn essence it is a kind of or
It is several.
Preparation method: taking each component described in formula,
1, titanium dioxide, dipotassium glycyrrhizinate, sodium benzoate, disodium ethylene diamine tetraacetate, dragon's blood extract is taken to set cleaning
Container in, add a small amount of water to stir, make it dissolve, obtain lysate, it is spare；
2, weigh carragheen, cellulose gum is set in clean container, sequentially add glycerol, the pure and mild a small amount of water of sorb (sugar)
Solution, stirring makes it be swelled into glue, obtains glue, spare；
3, it takes above-mentioned glue to set in above-mentioned lysate, stirs evenly, obtain mixed solution, it is spare；
4, above-mentioned mixed solution is taken, hydrated silica, laruyl alcohol sodium sulfovinate, essence are added under stirring, adds water to
Prepare total amount, be uniformly mixed, vacuum outgas 10-60min, it is filling to get.
It is of the present invention a kind of with the Resina Draconis toothpaste for preventing and treating the diseases such as canker sore, mainly for oral cavity
The prevention and treatment of ulcer, various focusing depths represented, periodontitis, chronic pharyngitis, mouth syndrome of burning.
It realizes and treats or prevents effect effective dose scope of the invention in about 0.001-100mg/ kg body weight/day.Weekly,
Every two weeks or the dosage range of every three weeks application medicaments can be about 0.01-1000mg/ subject's kg body weight, more be often
0.1-10000mg/ subject's kg body weight.Administration dosage can be prevention or therapeutic purposes with processing and change.It is preventative to answer
With the relatively low dosage of middle application.Relatively high dosage is needed in therapeutic application, shows part preferably of up to subject
Or complete disease symptoms improve.
Beneficial effect
The present invention is a kind of with Resina Draconis toothpaste of diseases such as canker sore and preparation method thereof are prevented and treated, and being will be imperial
Sanguis Draxonis extract is dissolved or dispersed in certain matrix, and being prepared into has to canker sore, various focusing depths represented, periodontitis, chronic
Pharyngitis, mouth syndrome of burning have the toothpaste of good therapeutic effect.
Specific embodiment
Embodiment 1 (investigates dragon's blood extract and inhibits or fight oral bacteria growth, to prove its effectively pre- anti-caries
)
Test method:
The oral bacteria sample for being derived from diastema is collected with dental toothpick, sample comes from 16 normal subjects (8 male 8
Female).Sample toothpick is distinguished into sterile streak inoculation on sweet dew alkoxide agar (MSA) plate.The plate of the culture inoculation at 37 DEG C.
MSA plate containing only 0.2% Chlorhexidine, 0.2% benzoic acid, 0.4% p-hydroxybenzoate, 0.3% triclosan,
One of 0.15% potassium sorbate preservative is used as positive control.For each culture study subject, measure in batch culture
The maximum suppression dilution (MID) of dragon's blood extract.Object of this investigation be by this five kinds of commercialized preservatives with not
Dragon's blood extract with concentration is compared, and compares them to the oral cavity to play an important role in the generation of saprodontia and gingivitis
The inhibiting effect of bacterial growth.
The culture sample culture in 37 DEG C of incubators, reaches the bacterial density of culture between 0.5x109To 1x109Carefully
When born of the same parents/ml density, for being inoculated with the secondary culture containing various preservatives or multiple concentration dragon's blood extracts.Pass through difference
The bacterial clump on culture plate is counted, to determine existing 5 kinds of preservatives and dragon's blood extract for from different subjects
The growth inhibition effect of the oral bacteria of acquisition.
As shown in table 1, it the results show that the concentration in dragon's blood extract is 0.03%, is observed in the culture of processing
To bacteria colony count and the clump count phase observed in the oral bacteria culture of above-mentioned common 5 preservatives processing
When.However, the clump count of processed sample reduces about 50% when dragon's blood extract concentration reaches 0.1%.When with
When 0.5% dragon's blood extract handles culture, it is barely perceivable bacterial clump.And containing above-mentioned 5 kinds of preservatives
On culture plate, oral bacteria bacterium colony has been paved in the full visual field.We further test dragon's blood extract in liquid bacterial
In culture, to the oral bacteria growth inhibition effect obtained from the subject for suffering from stomatitis.
Table 1
| Active constituent content | Clump count (a) | |
| Chlorhexidine (a) | 0.2% | 89 |
| P-hydroxybenzoate (b) | 0.4% | 72 |
| Benzoic acid (c) | 0.2% | 90 |
| Potassium sorbate (d) | 0.15% | 75 |
| Triclosan (e) | 0.3% | 101 |
| Dragon's blood extract (1) | 0.03% | 78 |
| Dragon's blood extract (2) | 0.1% | 32 |
| Dragon's blood extract (3) | 0.5% | 0 |
Shown in table 1, it is shown that inhibiting effect of the dragon's blood extract to Human Oral Cavity bacterial growth.A-e is recommended density
Five kinds selected by preservative, test sample is (1), (2), (3) 3 various concentrations dragon's blood extract culture medium, display dragon
Sanguis Draxonis extract has stronger dose-dependent inhibition effect to oral cavity bacterial growth, when dragon's blood extract concentration reaches
When 0.1%, the clump count of processed sample is only 32.When handling culture with 0.5% dragon's blood extract, do not have
Observe bacterial clump.And on the culture plate containing above-mentioned 5 kinds of preservatives, oral bacteria bacterium colony has been paved in the full visual field.
We further test dragon's blood extract in liquid bacterial culture, to from the oral cavity that the subject for suffering from stomatitis obtains
Bacterial growth inhibiting effect.
Embodiment 2 (dragon's blood extract inhibits the plaque in oral cavity to be formed)
Human experimenter's (n=10, age are 20-60 years old) of subject group is brushed teeth using dragon's blood extract toothpaste (3%),
And subject's (n=10, age are 20-60 years old) of control group is brushed teeth using identical but without dragon's blood extract toothpaste, often
Day once in the morning and once at night, brushes teeth at least 2 minutes every time.The PLI that two groups of all subjects are evaluated before application is tested toothpaste, as a result shows
Show, PLI is averagely respectively about 2.92 ± 1.23 (subject groups) and 2.88 ± 1.25 (control groups) (referring to table 2).As the result is shown with
Use dragon's blood extract toothpaste, the PLI of subject group score progressive decline (after use the 1st week be the 1.60 ± 0.67, the 2nd week
It is the 0.77 ± 0.32, the 4th week for 0.32 ± 0.10) (p < 0.001).In contrast to this, the PLI of control group scores without significantly changing
(be within the 1st week after application control toothpaste the 2.40 ± 1.14, the 2nd week be the 2.33 ± 1.29, the 4th week be 2.35 ± 1.11).It is more significant
, after the application toothpaste 2 weeks, when being checked before two groups of subjects brush teeth in the morning, the dental surface of subject group
Keep smooth, no obvious mycoderm is formed, and PLI is about 1.09 ± 0.43.The dental surface of control group subject covers thin and thick
Rough mycoderm, PLI are about 4.09 ± 1.88 (p < 0.001).
Table 2
| Dragon's blood extract toothpaste (3%) PLI | Control group PLI | |
| 0 week | 2.92±1.23 | 2.88±1.25 |
| 1 week | 1.60±0.67 | 2.40±1.14 |
| 2 weeks | 0.77±0.32 | 2.33±1.29 |
| 4 weeks | 0.32±0.10 | 2.35±1.11 |
| BT | 1.40±0.58 | 2.49±1.20 |
Shown in table 2, dragon's blood extract is inhibited to bacterial growth, therefore plaque is formed in tooth surface
Inhibiting effect can be effectively protected tooth, avoid halitosis, saprodontia and oral inflammation.
Embodiment 3 (investigates effect of the dragon's blood extract to bleeding gums)
3% dragon's blood extract toothpaste is used for subject (20 people, the age 20- of acute or chronic bleeding gums
75).It was found that brushed teeth 2 minutes with dragon's blood extract, it is each primary daily morning and evening, after 1-3 days, the gum of all subjects can be made to go out
Blood all significantly improves, or stops bleeding gums completely.According to bleeding gums severity, stop needed for bleeding gums
Number of days is 1-3 days.Wherein in 12, bleeding gums disappear after being brushed teeth 1 day with dragon's blood extract.In other 8, dragon's blood is used
Bleeding gums stop after draconis extract is treated 3 days.And 20 bleeding gums patients of control group, using without dragon's blood extract
Control toothpaste during, only 2 stop bleeding gums after brushing teeth 1 week.
With following several embodiments, illustrate the preparation process of Resina Draconis toothpaste
Embodiment 4 (prepares 50 parts of Resina Draconis toothpaste)
1,1.0 parts of above-mentioned titanium dioxide, 1.0 parts of dipotassium glycyrrhizinate, 0.4 part of sodium benzoate, disodium ethylene diamine tetraacetate are taken
0.25 part, 1.0 parts of dragon's blood extract is set in clean container, is added a small amount of water to stir, is made it dissolve, obtain lysate, spare；
2, weigh 0.5 part of above-mentioned carragheen, 0.5 part of cellulose gum set in clean container, sequentially add 10 parts of glycerol, mountain
20 parts of pears (sugar) alcohol and a small amount of aqueous solution, stirring makes it be swelled into glue, obtains glue, spare；
3, it takes above-mentioned glue to set in above-mentioned lysate, stirs evenly, obtain mixed solution, it is spare；
4, above-mentioned mixed solution is taken, 5.0 parts of above-mentioned hydrated silica, laruyl alcohol sodium sulfovinate 0.3 are added under stirring
Part, 0.05 part of essence, add water to prepare 50 parts of total amount, be uniformly mixed, vacuum outgas 10-60min, it is filling to get.
Embodiment 5 (prepares 100 parts of Resina Draconis toothpaste)
1,2.0 parts of above-mentioned titanium dioxide, 2.0 parts of dipotassium glycyrrhizinate, 0.5 part of sodium benzoate, disodium ethylene diamine tetraacetate are taken
0.5 part, 2.0 parts of dragon's blood extract is set in clean container, is added a small amount of water to stir, is made it dissolve, obtain lysate, spare；
2, weigh 2.0 parts of above-mentioned carragheen, 2.0 parts of cellulose gum set in clean container, sequentially add 40 parts of glycerol, mountain
20 parts of pears (sugar) alcohol and a small amount of aqueous solution, stirring makes it be swelled into glue, obtains glue, spare；
3, it takes above-mentioned glue to set in above-mentioned lysate, stirs evenly, obtain mixed solution, it is spare；
4, above-mentioned mixed solution is taken, 20 parts of above-mentioned hydrated silica, laruyl alcohol sodium sulfovinate 3.0 are added under stirring
Part, 2.0 parts of essence, add water to prepare 100 parts of total amount, be uniformly mixed, vacuum outgas 10-60min, it is filling to get.
Embodiment 6 (prepares 100 parts of Resina Draconis toothpaste)
1,1.0 parts of above-mentioned titanium dioxide, 3.0 parts of dipotassium glycyrrhizinate, 2.0 parts of sodium benzoate, disodium ethylene diamine tetraacetate are taken
2.0 parts, 1.0 parts of dragon's blood extract are set in clean container, are added a small amount of purified water to stir, are made it dissolve, obtain lysate, standby
With；
2, weigh 1.0 parts of above-mentioned carragheen, 1.0 parts of cellulose gum set in clean container, sequentially add 30.0 parts of glycerol,
30.0 parts of sorb (sugar) alcohol and a small amount of purified water, stirring makes it be swelled into glue, obtains glue, spare；
3, it takes above-mentioned glue to set in above-mentioned lysate, stirs evenly, obtain mixed solution, it is spare；
4, above-mentioned mixed solution is taken, 20.0 parts of above-mentioned hydrated silica, laruyl alcohol sodium sulfovinate 2.0 are added under stirring
Part, 1.0 parts of essence, add purified water to prepare 100 parts of total amount, be uniformly mixed, vacuum outgas 10-60min, it is filling to get.
Above-mentioned to prepare in Resina Draconis toothpaste Examples, embodiment 6 is best, no matter because in prepare glue and last filling
In dress, forming process, it is easy to get compared to other embodiments.
Claims (5)
1. a kind of with Resina Draconis toothpaste of diseases such as prevention and treatment canker sore and preparation method thereof, it is characterised in that each group
Divide by weight, is by 0.01-2 parts of dragon's blood extract, 10-60 parts of sorb (sugar) alcohol, 4-35 parts of hydrated silica, glycerol 5-
30 parts, 0.3-3 parts of laruyl alcohol sodium sulfovinate, 0.01-2 parts of essence, 0.1-2 parts of carragheen, 0.1-2 parts of cellulose gum, titanium dioxide
0.1-2 parts of titanium, 0.5-5 parts of dipotassium glycyrrhizinate, 0.1-3 parts of sodium benzoate, 0.2-4 parts of disodium ethylene diamine tetraacetate, appropriate amount of water group
At.
2. essence as described in claim 1, it is characterised in that can be orange essence or flavoring banana essence or flavoring apple essence or hawthorn
Essence is one or more of.
3. preparation method as described in claim 1 takes each component described in claim 1, it is characterised in that the preparation method is as follows:
3.1, titanium dioxide, dipotassium glycyrrhizinate, sodium benzoate, disodium ethylene diamine tetraacetate, dragon's blood extract are weighed and sets clean appearance
In device, adds a small amount of water to stir, make it dissolve, obtain lysate, it is spare；
3.2, weigh carragheen, cellulose gum is set in clean container, sequentially add pure and mild on a small quantity water-soluble of glycerol, sorb (sugar)
Liquid, stirring makes it be swelled into glue, obtains glue, spare；
3.3, it takes above-mentioned glue to set in above-mentioned lysate, stirs evenly, obtain mixed solution, it is spare；
3.4, above-mentioned mixed solution is taken, hydrated silica, laruyl alcohol sodium sulfovinate, essence are added under stirring, adds water to and matches
Total amount processed is uniformly mixed, vacuum outgas 10-60min, it is filling to get.
4. preparation method as claimed in claim 1 or 3, it is characterised in that it is preferred the preparation method is as follows:
4.1, take 1.0 parts of titanium dioxide, 3.0 parts of dipotassium glycyrrhizinate, 2.0 parts of sodium benzoate, 2.0 parts of disodium ethylene diamine tetraacetate,
1.0 parts of dragon's blood extract are set in clean container, are added a small amount of purified water to stir, are made it dissolve, obtain lysate, spare；
4.2, weigh 1.0 parts of carragheen, 1.0 parts of cellulose gum set in clean container, sequentially add 30.0 parts of glycerol, sorb
30.0 parts of (sugar) alcohol and a small amount of purified water, stirring makes it be swelled into glue, obtains glue, spare；
4.3, it takes above-mentioned glue to set in above-mentioned lysate, stirs evenly, obtain mixed solution, it is spare；
4.4, above-mentioned mixed solution is taken, 20.0 parts of above-mentioned hydrated silica, laruyl alcohol sodium sulfovinate 2.0 are added under stirring
Part, 1.0 parts of essence, add purified water to prepare 100 parts of total amount, be uniformly mixed, vacuum outgas 10-60min, it is filling to get.
5. a kind of with the Resina Draconis toothpaste for preventing and treating the diseases such as canker sore as described in claim 1, it is characterised in that
Prevention and treatment of the toothpaste mainly for canker sore, various focusing depths represented, periodontitis, chronic pharyngitis, mouth syndrome of burning.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811213975.7A CN109044933B (en) | 2018-10-18 | 2018-10-18 | Application of dragon's blood extract in preparing toothpaste for inhibiting dental plaque |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811213975.7A CN109044933B (en) | 2018-10-18 | 2018-10-18 | Application of dragon's blood extract in preparing toothpaste for inhibiting dental plaque |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN109044933A true CN109044933A (en) | 2018-12-21 |
| CN109044933B CN109044933B (en) | 2020-01-21 |
Family
ID=64764152
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201811213975.7A Active CN109044933B (en) | 2018-10-18 | 2018-10-18 | Application of dragon's blood extract in preparing toothpaste for inhibiting dental plaque |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN109044933B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114949105A (en) * | 2022-06-09 | 2022-08-30 | 云南大唐汉方制药股份有限公司 | Medicinal toothpaste for preventing and treating oral mucositis caused by radiotherapy and chemotherapy |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101647768A (en) * | 2009-09-08 | 2010-02-17 | 上海大学 | Process for preparing Chinese herbal medicine toothpaste containing dragon's blood extract |
| CN107184481A (en) * | 2017-06-21 | 2017-09-22 | 广州市博真电子科技有限公司 | A kind of ginseng toothpaste and preparation method thereof |
| CN108096133A (en) * | 2016-11-24 | 2018-06-01 | 云南民族大学 | Mobyneb Resina Draconis toothpaste |
-
2018
- 2018-10-18 CN CN201811213975.7A patent/CN109044933B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101647768A (en) * | 2009-09-08 | 2010-02-17 | 上海大学 | Process for preparing Chinese herbal medicine toothpaste containing dragon's blood extract |
| CN108096133A (en) * | 2016-11-24 | 2018-06-01 | 云南民族大学 | Mobyneb Resina Draconis toothpaste |
| CN107184481A (en) * | 2017-06-21 | 2017-09-22 | 广州市博真电子科技有限公司 | A kind of ginseng toothpaste and preparation method thereof |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114949105A (en) * | 2022-06-09 | 2022-08-30 | 云南大唐汉方制药股份有限公司 | Medicinal toothpaste for preventing and treating oral mucositis caused by radiotherapy and chemotherapy |
Also Published As
| Publication number | Publication date |
|---|---|
| CN109044933B (en) | 2020-01-21 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN105310960B (en) | A kind of novel polysaccharide antimicrobial mouthwash and preparation method thereof | |
| CN1927160A (en) | Gargle and its preparing process | |
| KR20080025330A (en) | Oral cavity cleaning composition | |
| US20120288454A1 (en) | Dental protection toothpaste composition | |
| CN107811890A (en) | A kind of oral cavity caring toothpaste composition | |
| CN109223663A (en) | A kind of Chinese herbal toothpaste and preparation method thereof for gingivitis | |
| CN112263606A (en) | Traditional Chinese medicine gargle and preparation method thereof | |
| CN106176315B (en) | A kind of mouthwash and preparation method thereof | |
| CN109044933A (en) | It is a kind of with preventing and treating Resina Draconis toothpaste of diseases such as canker sore and preparation method thereof | |
| CN107397805B (en) | Improve oral hygiene, prevention and the composition and preparation method for the treatment of mouth disease | |
| Prakash et al. | Effect of punica granatum extract gel on gingival crevicular fluid levels of interleukin-1β, interleukin-8 and CCL28 levels: randomised controlled clinical trial | |
| CN112076221B (en) | Desensitizing paste and preparation method and application thereof | |
| RU2751810C1 (en) | Method for treatment of chronic periodontitis | |
| CN109846786B (en) | Traditional Chinese medicine mouth wash and preparation method and application thereof | |
| CN105213216B (en) | A kind of natural disaccharide antibacterial shield tooth gargle and preparation method thereof | |
| RU2708615C1 (en) | Method of treating chronic periodontitis | |
| CN1038935A (en) | Jiekouye gargle | |
| CN113577098A (en) | Application of magnesium hydride in preparation of composition for preventing and treating chronic periodontitis and magnesium hydride toothpaste | |
| WO2009029434A2 (en) | Anti-microbial fluoride rinses, and methods of use thereof | |
| RU2355379C1 (en) | Therapeutic-preventive dentifrice water and method for making thereof | |
| RU2618889C1 (en) | Mouthwash agent having antiinflammatory, antimicrobial, wound-healing effect | |
| CN110496165A (en) | A kind of Chinese medicine composition for treating periodontitis | |
| Pasiga et al. | Clinical effects of alkaline ionization water (AIW) as a mouthwash against the reduction of dental plaque | |
| Shafiei Bafti et al. | An in vivo evaluation of antimicrobial effects of Persica herbal mouthwash on Candida albicans and Enterococcus faecalis | |
| RU2810419C1 (en) | Method of chronic periodontitis treatment |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: Application of Dragon's Blood Extract in the Preparation of Toothpaste for Inhibiting Dental Plaque Effective date of registration: 20230421 Granted publication date: 20200121 Pledgee: Industrial and Commercial Bank of China Limited Pu'er Branch Pledgor: YUNNAN DATANG HANFANG PHARMACEUTICAL CO.,LTD. Registration number: Y2023980038716 |
|
| PE01 | Entry into force of the registration of the contract for pledge of patent right |