CN109453044A - A kind of multiple-effect type polishing of teeth cream - Google Patents
A kind of multiple-effect type polishing of teeth cream Download PDFInfo
- Publication number
- CN109453044A CN109453044A CN201811480320.6A CN201811480320A CN109453044A CN 109453044 A CN109453044 A CN 109453044A CN 201811480320 A CN201811480320 A CN 201811480320A CN 109453044 A CN109453044 A CN 109453044A
- Authority
- CN
- China
- Prior art keywords
- factor
- teeth
- effect type
- type polishing
- teeth cream
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/20—Halogens; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/24—Phosphorous; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/25—Silicon; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/35—Ketones, e.g. benzophenone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
- A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/55—Phosphorus compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/63—Steroids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/66—Enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/987—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/28—Rubbing or scrubbing compositions; Peeling or abrasive compositions; Containing exfoliants
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Emergency Medicine (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Zoology (AREA)
- Cosmetics (AREA)
Abstract
Present invention relates particularly to a kind of field of oral care, a kind of multiple-effect type polishing of teeth cream is disclosed, polishing of teeth cream is made of following component: rubbing agent, D-sorbite, surfactant, menthol, anti-inflammatory factors, hemostatic factor, the antiallergic factor, the whitening factor, Sucralose, bacteriostatic agent, food-grade essence, plant extracts and water.Compared with prior art, the present invention is using biological enzyme formulation and polysaccharide compound as bacteriostatic agent, and with other components matchings, the polishing of teeth cream product of multiple-effect is combined with anti-inflammatory, whitening, antiallergic, hemostasis, simultaneously, primary raw material of the present invention has the advantages that safe and pollution-free, small to enamel lesions, the main component of antiscuffing paste is using mild spherical friction material, plant extracts, with certain antiphlogistic antibacterial ability, the present invention has the characteristics that comprehensive anti-inflammatory, antibacterial, whitening, antiallergic, hemostasis multiple effect.
Description
Technical field
The present invention relates to field of oral care more particularly to one kind to have anti-inflammatory, antibacterial, whitening, antiallergic, hemostasis multiple-effect type
Polishing of teeth cream.
Background technique
The substances such as cigarette, tea, coffee, coloured food in daily life, residue easily pass through the saliva egg of dental surface
White organic film deposition is not cleaned timely and effectively such as in facing, by accumulating for a long time, can lead to tooth and gradually become
Yellow even blackening, forms dental exogenous mottle and spot, not only influences oral hygiene, but also influence beautiful teeth.Three or four time
It flows adjusting data and shows that Chinese calculus dentalis recall rate is high, currently, medical circle of oral cavity clinical test proof periodically cleans one's teeth
It is the important means to take care of one's teeth, and the common people clean one's teeth, idea is not strong, for the Rational Solutions mistaken ideas that clean one's teeth, it is believed that clean one's teeth and hurt tooth, bring
Sense of discomfort, such as: tooth be easy it is sensitive, feel to ache, bleeding the case where, unclean tooth causes numerous oral healths to ask for a long time
Topic.In view of the feature that China oral cavity status and the cognition of consumer's oral health are weak, and lack the behavior periodically to clean one's teeth, leads
The malaise symptoms occurred when cleaning one's teeth are caused, a kind of pair of tooth is developed on existing market and clean one's teeth the antiscuffing paste of subsequent polishing.Mesh
Before, the common polishing of teeth cream of dental clinic is calcium carbonate matrix, since its calcium carbonate matrix granule is big, be will cause to enamel
Certain damage.Invention CN106539697A also discloses a kind of preventing decayed tooth antiallergic antiscuffing paste and preparation method thereof, including following heavy
Measure the component of percentage: 0.5% quaternary ammonium salt, 2% non-ionic surface active, 0.25% sodium pyrophosphate, 0.85%
CMC, 0.5% sodium benzoate, 5% precipitating carbamic acid calcium, 45% dibastic sodium phosphate dihydrate, 22% glycerol,
The edible essence of 0.1-0.3%, the food antiseptics of 0.1-0.3%, 0.2% sweetener, 0.08-0.2% freshener and
The pigment of 0.0001-0.0002%.Foregoing invention is added to ammonium hexafluorosilicate as functional material in antiscuffing paste, and existing
Antiallergic toothpaste compare, the effect of antiallergic sense, is more significant；It is in good taste；And not spirituosity, reduce the carcinogenic danger of alcohol, more
Safety；The side effects such as tooth discoloration are not generated；Also have the function of preventing decayed tooth and sterilization simultaneously, can preferably safeguard oral health.
But it has a single function, and can not effectively prevent and treat other oral health issues, and the crowd for being unable to satisfy different oral problems needs
It asks.
Summary of the invention
In view of this, the present invention is directed to the demand of common oral problem and tooth whitening, design is a to reach anti-inflammatory, suppression
Bacterium, whitening, antiallergic, hemostasis multiple-effect type polishing of teeth cream.
To solve the above-mentioned problems, the technical scheme is that
A kind of multiple-effect type polishing of teeth cream, is made of the material of following proportion: rubbing agent, D-sorbite, surfactant,
Menthol, anti-inflammatory factors, hemostatic factor, the antiallergic factor, the whitening factor, thickener, Sucralose, bacteriostatic agent, food-grade essence, plant
Object extract, pure water.
Further, a kind of multiple-effect type polishing of teeth cream, is made of the component of following weight ratio: rubbing agent 20-40%, mountain
Pears sugar alcohol 30-50%, surfactant 2.0-3.0%, menthol 0.1-0.3%, anti-inflammatory factors 0.01-0.03%, hemostasis because
Sub- 0.05-0.2%, antiallergic factor 0.1-0.3%, whitening factor 0.5-2%, thickener 0.8-1.3%, Sucralose 0.1-
0.4%, bacteriostatic agent 0.0002%-0.001%, food-grade essence 0.8-2.0%, plant extracts 0.05-0.2%, pure water
Surplus.
Further, the rubbing agent is silica, and the silica is preparing spherical SiO 2, relative friction value
It is 280；It is described to be made of friction-type silica, thickening type silica and high friction-type silica, compound proportion 4:
2:1。
Further, the surfactant is sodium cocoyl glutamate, and the anti-inflammatory factors are Paeonols, the hemostasis
The factor is tranexamic acid, and the antiallergic factor is potassium nitrate or strontium chloride；The whitening factor is sodium phytate or hydroxyapatite, institute
Stating food-grade essence is one or both of caryophyllus oil, lemon sesame oil, peppermint oil dementholized, Thymol, fruit perfume (or spice) phenol.
Further, the plant extracts is that dipotassium glycyrrhizinate, nutgall extractive, grape fruit extract, the bletilla striata mention
Take one or both of object, magnolol, tea polyphenols, Anoectochilus.
Further, total dosage of the Sucralose and menthol is 2-7 ‰, and total amount is excessively high, will increase to oral stimulation.
Further, the bacteriostatic agent is superoxide dismutase (superoxidedismutase, SOD), and concentration is
30000U/mg.I.e. are as follows: every milligram of superoxide dismutase contains 30000 unit vigor；With SOD inhibiting rate in every mg reaction solution
Corresponding SOD amount is defined as a unit of activity when up to 50%.
Further, the bacteriostatic agent is the compound of superoxide dismutase and ganoderma lucidum polysaccharide, superoxide dismutase
It is 1:2-1:6 with ganoderma lucidum polysaccharide compositely proportional.
Ganoderma lucidum (Ganoderma lucidum) also known as seocho, sesame grass, is the health care product of the traditional dual-purpose of drug and food in China.Spirit
Sesame is Basidiomycetes Polyporaceae Ganoderma fungi, with a long history as drug.The application of modern science and technology makes ganoderma lucidum
Research it is more deep.Ganoderma lucidum and its effective component have extensive pharmacological action, can prevent and treat chronic bronchitis, neurasthenia,
The diseases such as hyperlipemia, coronary heart disease, hepatitis, oligoleukocythemia, tumour.Ganoderma lucidum polysaccharide is the important component of ganoderma lucidum, have it is antitumor,
Immunological enhancement, studies have shown that the medicinal ingredient of ganoderma lucidum is very rich, it is separated to effective component have as many as tens of kinds,
Ganoderma lucidum polysaccharide Ganoderma lucidum polysaccharides therein) have multiple pharmacological effect, such as it is antitumor, mention
High immunity of organisms, resist oxygen lack, elimination interior free yl, anti-radiation, heat-clearing etc..
Superoxide dismutase (SOD) is considered as enzyme most magical in Life Science, the intracorporal rubbish street cleaner of people, is machine
The number one killer of internal oxygen radical is life and health sheet.The presence meeting of the intracorporal excessive ultra-oxygen anion free radical of biology
Influence the vital movement of human normal.SOD mainly pass through anti-DNA damnification, anti peroxidation of lipid, prevent internal dehydratase inactivation,
The destruction to mitochondrial oxy-reduction enzyme element is prevented to prevent the damage of free radical.
Beneficial effects of the present invention: the present invention uses high cleaning, low abrasion type silica for abrasive material, mainly passes through machinery
Friction effect removes tooth spot, and the friction value (RDA) of antiscuffing paste is 120~150, and cleaning value (PCR) is 90~100, and is sieved
Suitable additive amount is selected, even particle size, hardness are moderate, cleaning capacity is strong, physicochemical properties are stable, with other compositions
Compatibility is good, smaller to the abrasion of dental hard tissue；The present invention uses biological enzyme to be coupled compound with polysaccharide as bacteriostatic agent,
While reaching removal tooth exogenous tooth stain effect, inhibit bacteria breed, reduce plaque, mitigate calculus dentalis, improves facing
Finish, effectively reduce pigment and spot in the formation again of facing, to enhance toothpaste whitening function, and can alleviate
Sensitivity of tooth after cleaning one's teeth slows down bleeding gums, and meet demand is without side-effects simultaneously.The product has anti-inflammatory, antibacterial, whitening, resists
Quick, hemostasis multiple-effect type polishing of teeth cream, meets the needs of the majority of consumers protect the health of one's mouth comprehensively.
Detailed description of the invention
Fig. 1 is the polishing of various concentration superoxide dismutase monomer and superoxide dismutase and ganoderma lucidum polysaccharide compound
The fungistatic effect of cream compares map.
Fig. 2 is the antiscuffing paste fungistatic effect figure of not bacteriostatic agent.
Fig. 3 is the antiscuffing paste fungistatic effect figure of the monomer containing superoxide dismutase.
Fig. 4 is the antiscuffing paste fungistatic effect figure containing superoxide dismutase Yu ganoderma lucidum polysaccharide compound 0.0002%.
Fig. 5 is the antiscuffing paste fungistatic effect figure containing superoxide dismutase Yu ganoderma lucidum polysaccharide compound 0.0005%.
Fig. 6 is the antiscuffing paste fungistatic effect figure containing superoxide dismutase Yu ganoderma lucidum polysaccharide compound 0.001%.
Fig. 7 is the antiscuffing paste of superoxide dismutase containing various concentration and ganoderma lucidum polysaccharide compound to plaque reduced rate
Compare figure.
Specific implementation method
Embodiment 1
A kind of polishing of teeth cream, the antiscuffing paste contain the composition of following weight ratio: 40 parts of D-sorbite, 20 parts of rubbing agent,
2.4 parts of surfactant, 0.1 part of menthol, 0.01 part of anti-inflammatory factors, 0.05 part of hemostatic factor, 0.1 part of the antiallergic factor, whitening
0.5 part of the factor, 0.8 part of thickener, 0.1 part of Sucralose, 0.8 part of food-grade essence, 0.05 part of plant extracts, superoxides discrimination
Change 0.0002 part of enzyme, pure water surplus.
Preparation method, comprising the following steps:
(1) rubbing agent, thickener, surfactant are added in powder tank and are stirred evenly for use.
(2) by anti-inflammatory factors, hemostatic factor, the antiallergic factor, the whitening factor, plant extracts, superoxide dismutase, sugarcane
Sugared element is uniformly dissolved in deionized water, is pumped into cream pot and is stirred together with D-sorbite.
(3) cream pot processed is vacuumized, then powder stand-by in the powder tank is pumped into the cream pot processed, high vacuum mixing
Food-grade essence, menthol, preservative are added after uniformly to stir evenly, deaerate.
Embodiment 2
A kind of multiple-effect type polishing of teeth cream, the antiscuffing paste contain the composition of following weight ratio: 40 parts of D-sorbite, rubbing agent
20 parts, 2.4 parts of surfactant, 0.1 part of menthol, 0.01 part of anti-inflammatory factors, 0.05 part of hemostatic factor, 0.1 part of the antiallergic factor,
0.5 part of the whitening factor, 0.8 part of thickener, 0.1 part of Sucralose, 0.8 part of food-grade essence, 0.05 part of plant extracts, super oxygen
Object mutase with 0.0002 part of ganoderma lucidum polysaccharide compound, pure water surplus.
Preparation method, comprising the following steps:
Rubbing agent, thickener, surfactant are added in powder tank and stirred evenly for use.
By anti-inflammatory factors, hemostatic factor, the antiallergic factor, the whitening factor, plant extracts, superoxide dismutase and ganoderma lucidum
Compound, Sucralose are uniformly dissolved in deionized water, are pumped into cream pot and are stirred together with D-sorbite.
Cream pot processed is vacuumized, then powder stand-by in the powder tank is pumped into the cream pot processed, high vacuum mixing is equal
Food-grade essence, menthol, preservative are added after even to stir evenly, deaerate.
Embodiment 3
A kind of multiple-effect type polishing of teeth cream, the composition containing following weight ratio: 30 parts of rubbing agent, 40 parts of D-sorbite, table
2.5 parts of face activating agent, 0.2 part of menthol, 0.02 part of anti-inflammatory factors, 0.1 part of hemostatic factor, 0.2 part of the antiallergic factor, the whitening factor
0.1 part, 1.0 parts of thickener, 0.2 part of Sucralose, 1.2 parts of food-grade essence, 1.0 parts of plant extracts, superoxide dismutase
With 0.0005 part of ganoderma lucidum polysaccharide compound, pure water surplus.
Preparation method is same as above.
Embodiment 4
A kind of multiple-effect type polishing of teeth cream, the composition containing following weight ratio: 40 parts of rubbing agent, 30 parts of D-sorbite, table
2.5 parts of face activating agent, 0.25 part of menthol, 0.03 part of anti-inflammatory factors, 0.2 part of hemostatic factor, 0.3 part of the antiallergic factor, whitening because
Sub 2.0 parts, 1.3 parts of thickener, 0.4 part of Sucralose, 2.0 parts of food-grade essence, 0.2 part of plant extracts, superoxide dismutase
Enzyme with 0.001 part of ganoderma lucidum polysaccharide compound, pure water surplus.
Preparation method is same as above.
Comparative example:
Common antiscuffing paste, the composition containing following weight ratio: 40.0 parts of glycerol, 20 parts of calcium carbonate, surfactant 2.4
Part, 0.1 part of menthol, 0.8 part of thickener, 0.1 part of Sucralose, 0.8 part of essence, pure water surplus.
Preparation method:
(1) calcium carbonate, thickener, surfactant are added in powder tank and are stirred evenly for use.
(2) Sucralose is uniformly dissolved in deionized water, is pumped into cream pot and stirs together with glycerol.
(3) cream pot processed is vacuumized, then powder stand-by in the powder tank is pumped into the cream pot processed, high vacuum mixing
Essence, menthol, preservative are added after uniformly to stir evenly, deaerate.
Experimental example 1:
It is compound with ganoderma lucidum polysaccharide using various concentration superoxide dismutase monomer and superoxide dismutase in experimental example 1
The fungistatic effect of the antiscuffing paste of object compares:
With reference to " disinfection technology standard " 2002 editions Ministry of Health of the People's Republic of China's 2.1.8.2 antibacterial ring size experiments, with golden yellow
Color staphylococcus A TCC6538 is experimental strain, according to malicious technical specification " 2.1.8.2.4 evaluation regulation, bacteriostasis judgement: sample
Product inhibition zone diameter > 7mm, being judged as has bacteriostasis.Sample inhibition zone diameter≤7mm, is judged as no bacteriostasis.
As a result as shown in Fig. 1, with the increase of superoxide dismutase and ganoderma lucidum polysaccharide complex concentration, inhibition zone is in
Existing widened trend, it can be deduced that superoxide dismutase and ganoderma lucidum polysaccharide complex concentration and inhibition zone have dose-dependant pass
System, and the bacteriostasis of compound is greater than the bacteriostasis of superoxide dismutase monomer.
Experimental example 2:
Bacteriostatic test containing different bacteriostatic agents with the when antiscuffing paste of concentration:
1) preparation of bacterial suspension: appropriate bacterial cultures is inoculated into the trypsinized soybean broth of 9mL, at 30 DEG C
Under environment culture 18~for 24 hours, then bacterium solution is inoculated on trypsinized soy agar, under 30 DEG C of environment cultivate 18~
24h.After culture, by the bacterium of purity check qualification, the concentration of bacterium colony is adjusted to 0.5 Maxwell with sterile saline
Turbidity makes bacterial concentration 2 × 108Cfu/mL or so also can carry out bacteria quantified with spectrophotometer.
2) culture of bacterial suspension: the bacterium solution quantitatively modulated uses the physiological saline of sterilizing to dilute bacterium solution as dilution
2 parts are taken at 105,106,107 each concentration, every part of each 1mL is inoculated on MTCA agar plate, and 30 DEG C are cultivated 4 days, and culture terminates
All bacterium colonies on each plate are counted afterwards and are recorded as a result, finally calculating the bacterial concentration of bacteria suspension.
Average × extension rate of bacterial concentration=two flat-plate bacterial colony sum
3) preparation of samples: the sample for being prepared into antiscuffing paste described in embodiment 1,2,3,4 and comparative example under aseptic condition point
Be not fitted into 5 sterilized oz glass vessel, original bacterium solution be modulated to 0.5 Maxwell turbidity (bacterial concentration 2 ×
108cfu/mL or so) bacteria suspension, be inoculated with and be uniformly mixed by 0.2mL/ container, sample seal and at normal temperature complete test.
4) sample culturing: the inoculated sample mixture of 1.0mL is successively taken out, is respectively diluted mixture with 9mLTMLB
After be inoculated in MCTA plate, cultivated 4 days under 30 DEG C of environment, count and keep a record after culture, as first time testing result.
The experiment being repeated once when from on-test by the 7th, 14,21,28 day, then detect 4 times, respectively as second to the 5th time
Testing result.
As a result as shown in attached drawing 2-6, the display of attached drawing 2 does not contain the antiscuffing paste comparative example of bacteriostatic agent and antibacterial compound, right
Staphylococcus aureus, streptococcus mutans, Escherichia coli are without bacteriostasis；Attached drawing 3 shows that embodiment 1 contains superoxide dismutase
Antiscuffing paste have preferable fungistatic effect；Attached drawing 4-6 shows that embodiment 2-4 is compound containing superoxide dismutase and ganoderma lucidum polysaccharide
The antiscuffing paste fungistatic effect of object 0.0002%-0.001% is significant, and concentration dependant effect, superoxide dismutase and spirit is presented
Sesame polysaccharide compound concentration is higher, and fungistatic effect is better.By the comparison of attached drawing 3 and attached drawing 4-6, containing superoxide dismutase with
The antiscuffing paste fungistatic effect of ganoderma lucidum polysaccharide compound is substantially better than the fungistatic effect of the antiscuffing paste containing only superoxide dismutase.
Experimental example 3:
Plaque reduced rate compares:
Subject, which first dips appropriate plaque with sterilized cotton swabs and shows that liquid is gently coated in, is carried out plaque dye by inspection facing
Color stops 30s, is then gargled 3 times with clear water, according to the Q-H plaque index scoring criteria of Tureskey improvement to Ramfjord
Index tooth bacterial plaque of tooth surface area carries out the score of plaque index value；6 Ramfjord index teeth 16 of each subject, 21,24,
36, the first plaque index of 41,44 buccal labial surface is A1, is then acted on using the antiscuffing paste.3 are gargled with clear water again after use
It is secondary, using plaque index A2 after same procedure inspection and record.The knots modification of plaque is A1-A2, and the reduced rate of plaque is
(A1-A2)/A1, the plaque index value score of every subject are the sum of score of 6 teeth divided by 6.After every single experiment
Restore daily cleaning measure, eliminate residual action existing for former antiscuffing paste and influences.After 3 days using another antiscuffing paste into
Row experiment, method is the same, and test antiscuffing paste is containing superoxide dismutase and ganoderma lucidum polysaccharide compound 0.00001%-0.002%
Antiscuffing paste.
As a result as shown in Fig. 7, from attached drawing it can be concluded that containing superoxide dismutase and ganoderma lucidum polysaccharide compound
The antiscuffing paste of 0.00001%-0.002% is to plaque inhibiting rate as superoxide dismutase and ganoderma lucidum polysaccharide complex group add
Amount increases, and bacterial plaque effect is inhibited to gradually increase, when superoxide dismutase and ganoderma lucidum polysaccharide compound additive amount are in 0.0015%-
Inhibit amount of bacterial plaque to be maintained at 90% when 0.002%, there is preferable inhibition bacterial plaque effect.
Experimental example 4:
Experimental subjects: choosing 50 backteeth sensitive patients that clean one's teeth, and be divided into 5 groups, and every group of 10 people choose one group of use
As a control group, other the four groups toothpaste for using the embodiment of the present invention 1,2,3,4 to prepare are as experimental group for comparative example toothpaste.
Requirement of experiment: five groups use antiscuffing paste after cleaning one's teeth.
Table 1 is acquisition information acquired results after experimental subjects test
Conclusion: the display of table 1 uses the antiscuffing paste of the embodiment of the present invention 1,2,3,4 after cleaning one's teeth, and to tooth-whitening and alleviates tooth
Tooth sensitivity is substantially better than the effect of the prior art in comparative example.
Experimental example 5:
Experimental subjects: bleeding gums patient after selection 50 cleans one's teeth, and 5 groups are divided into, every group of 10 people, choosing one group makes
As a control group with comparative example toothpaste, other the four groups toothpaste for using the embodiment of the present invention 1,2,3,4 to prepare are as experimental group.
Requirement of experiment: five groups use antiscuffing paste after cleaning one's teeth.
Table 2 is acquisition information acquired results after experimental subjects test
Conclusion: the display of table 2 is existing compared to comparative example using the polishing of teeth cream of the embodiment of the present invention 2,3,4 after cleaning one's teeth
The antiscuffing paste of technology, stimulates small, and alleviates gingivitis and bleeding gums effect is more more significant.
Beneficial effects of the present invention: the present invention uses high cleaning low abrasion type silica for abrasive material, mainly passes through machinery
Friction effect removes tooth spot, and the friction value (RDA) of antiscuffing paste is 120~150, and cleaning value (PCR) is 90~100, and is sieved
Suitable additive amount is selected, even particle size, hardness are moderate, cleaning capacity is strong, physicochemical properties are stable, with other compositions
Compatibility is good, smaller to the abrasion of dental hard tissue；The present invention uses biological enzyme to be coupled compound with polysaccharide as bacteriostatic agent,
While reaching removal tooth exogenous tooth stain effect, inhibit bacteria breed, reduce plaque, mitigate calculus dentalis, improves facing
Finish, effectively reduce pigment and spot in the formation again of facing, to enhance toothpaste whitening function, and can alleviate
Sensitivity of tooth after cleaning one's teeth slows down bleeding gums, and meet demand is without side-effects simultaneously.The product has anti-inflammatory, antibacterial, whitening, resists
Quick, hemostasis multiple-effect type polishing of teeth cream, meets the needs of the majority of consumers protect the health of one's mouth comprehensively.
Typical case column: there are the symptoms such as hemodia, jaundice, oral inflammation, bleeding in Lee, 18 years old boy, and use is a plurality of
Polishing of teeth cream effect is bad, and feel toothpaste mouthfeel it is bad, be unwilling using；It is more using one kind of the invention upon somebody's introduction
After acting type polishing of teeth cream, daily using twice, tooth is cleaned, to eliminate the discomfort of tooth, after one month, hemodia, hair
The symptoms such as Huang, oral inflammation, bleeding disappear, and tooth is also more and more whiter, are adhered to daily using seldom there is the above mouth disease.
The above description is merely a specific embodiment, but scope of protection of the present invention is not limited thereto, any
The change or replacement expected without creative work, should be covered by the scope of protection of the present invention.
Claims (10)
1. a kind of multiple-effect type polishing of teeth cream, which is characterized in that be made of the material of following proportion: rubbing agent, D-sorbite, table
Face activating agent, menthol, anti-inflammatory factors, hemostatic factor, the antiallergic factor, the whitening factor, thickener, Sucralose, bacteriostatic agent, food
Grade essence, plant extracts, pure water.
2. a kind of multiple-effect type polishing of teeth cream according to claim 1, which is characterized in that by the component system of following weight ratio
At: rubbing agent 20-40%, D-sorbite 30-50%, surfactant 2.0-3.0%, menthol 0.1-0.3%, anti-inflammatory factors
0.01-0.03%, hemostatic factor 0.05-0.2%, antiallergic factor 0.1-0.3%, whitening factor 0.5-2%, thickener 0.8-
1.3%, Sucralose 0.1-0.4%, bacteriostatic agent 0.0002%-0.001%, food-grade essence 0.8.0-2.0%, plant extracts
0.05-0.2%, pure water surplus.
3. a kind of multiple-effect type polishing of teeth cream according to claim 1 or 2, which is characterized in that the rubbing agent is dioxy
SiClx, the silica are preparing spherical SiO 2, and relative friction value is 280.
4. a kind of multiple-effect type polishing of teeth cream according to claim 3, which is characterized in that the silica is by friction-type
Silica, thickening type silica and high friction-type silica composition, three's compound proportion are 4:2:1.
5. a kind of multiple-effect type polishing of teeth cream according to claim 1 or 2, which is characterized in that the surfactant is
Sodium cocoyl glutamate, the anti-inflammatory factors are Paeonols, and the hemostatic factor is tranexamic acid, and the antiallergic factor is potassium nitrate
Or strontium chloride, the whitening factor are sodium phytate or hydroxyapatite, the food-grade essence is caryophyllus oil, lemon sesame oil, thin
One or both of lotus vegetable oil, Thymol, fruit perfume (or spice) phenol.
6. a kind of multiple-effect type polishing of teeth cream according to claim 1 or claim 2, which is characterized in that the plant extracts is sweet
Oxalic acid dipotassium, nutgall extractive, grape fruit extract, bletilla striata extract, magnolol, tea polyphenols, in Anoectochilus
It is one or two kinds of.
7. a kind of multiple-effect type polishing of teeth cream according to claim 1 or claim 2, which is characterized in that the Sucralose and menthol
Total dosage be 2-7 ‰.
8. a kind of multiple-effect type polishing of teeth cream according to claim 1 or claim 2, which is characterized in that the bacteriostatic agent is super oxygen
Object mutase, concentration 30000U/mg.
9. a kind of multiple-effect type polishing of teeth cream according to claim 1 or claim 2, which is characterized in that the bacteriostatic agent is super oxygen
The compound of object mutase and ganoderma lucidum polysaccharide.
10. a kind of multiple-effect type polishing of teeth cream according to claim 9, which is characterized in that the superoxide dismutase with
Ganoderma lucidum polysaccharide compositely proportional is 1:2-1:6.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811480320.6A CN109453044B (en) | 2018-12-05 | 2018-12-05 | Multi-effect tooth polishing paste |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811480320.6A CN109453044B (en) | 2018-12-05 | 2018-12-05 | Multi-effect tooth polishing paste |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN109453044A true CN109453044A (en) | 2019-03-12 |
| CN109453044B CN109453044B (en) | 2021-12-31 |
Family
ID=65612497
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201811480320.6A Active CN109453044B (en) | 2018-12-05 | 2018-12-05 | Multi-effect tooth polishing paste |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN109453044B (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111135127A (en) * | 2020-01-19 | 2020-05-12 | 广东立爽生物科技有限公司 | Allergy-relieving and bleeding-stopping toothpaste and preparation method thereof |
| CN111904922A (en) * | 2020-08-04 | 2020-11-10 | 山东华素健康护理品有限公司 | Mild stain-removing whitening toothpaste and preparation process thereof |
| CN112641646A (en) * | 2019-10-12 | 2021-04-13 | 福建爱洁丽日化有限公司 | Toothpaste with whitening complexing agent and preparation method thereof |
| CN112999100A (en) * | 2021-02-26 | 2021-06-22 | 佛山市诺晟生物科技有限公司 | Anti-allergy polishing paste containing calcium potassium phosphosilicate bioglass |
| CN118178232A (en) * | 2024-03-19 | 2024-06-14 | 广州若鸿健康科技有限公司 | Novel tooth grinding and polishing preparation and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH01250304A (en) * | 1988-03-31 | 1989-10-05 | Kanebo Ltd | Skin cosmetic |
| CN102895147A (en) * | 2012-09-25 | 2013-01-30 | 广州中汉口腔用品有限公司 | Toothpaste with anti-inflammation and anti-allergic effects and making technology thereof |
| CN104188855A (en) * | 2014-08-20 | 2014-12-10 | 广州立白企业集团有限公司 | Traditional Chinese medicine toothpaste with effects of preventing and relieving tooth sensitivity |
-
2018
- 2018-12-05 CN CN201811480320.6A patent/CN109453044B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH01250304A (en) * | 1988-03-31 | 1989-10-05 | Kanebo Ltd | Skin cosmetic |
| CN102895147A (en) * | 2012-09-25 | 2013-01-30 | 广州中汉口腔用品有限公司 | Toothpaste with anti-inflammation and anti-allergic effects and making technology thereof |
| CN104188855A (en) * | 2014-08-20 | 2014-12-10 | 广州立白企业集团有限公司 | Traditional Chinese medicine toothpaste with effects of preventing and relieving tooth sensitivity |
Non-Patent Citations (2)
| Title |
|---|
| 贾少杰: "微博辅助法提取灵芝多糖工艺的优化及抑菌活性", 《北方园艺》 * |
| 韦世秀: "从海洋生物鲎血中提取超氧化物歧化酶及其抗菌作用的研究", 《蛇志》 * |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112641646A (en) * | 2019-10-12 | 2021-04-13 | 福建爱洁丽日化有限公司 | Toothpaste with whitening complexing agent and preparation method thereof |
| CN111135127A (en) * | 2020-01-19 | 2020-05-12 | 广东立爽生物科技有限公司 | Allergy-relieving and bleeding-stopping toothpaste and preparation method thereof |
| CN111904922A (en) * | 2020-08-04 | 2020-11-10 | 山东华素健康护理品有限公司 | Mild stain-removing whitening toothpaste and preparation process thereof |
| CN111904922B (en) * | 2020-08-04 | 2022-10-18 | 山东华素健康护理品有限公司 | Mild stain-removing whitening toothpaste and preparation process thereof |
| CN112999100A (en) * | 2021-02-26 | 2021-06-22 | 佛山市诺晟生物科技有限公司 | Anti-allergy polishing paste containing calcium potassium phosphosilicate bioglass |
| CN118178232A (en) * | 2024-03-19 | 2024-06-14 | 广州若鸿健康科技有限公司 | Novel tooth grinding and polishing preparation and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN109453044B (en) | 2021-12-31 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN109453044A (en) | A kind of multiple-effect type polishing of teeth cream | |
| TWI355945B (en) | ||
| TW201124173A (en) | Oral care composition | |
| CN107595750B (en) | Active anti-inflammation toothpaste | |
| CN109528601B (en) | Compound traditional Chinese medicine mouth wash and preparation method thereof | |
| US20200179258A1 (en) | Compositions, uses and methods for treating or preventing dental caries | |
| CN107811890A (en) | A kind of oral cavity caring toothpaste composition | |
| Ariamanesh et al. | The effectiveness of Nigella sativa alcoholic extract on the inhibition of Candida albicans colonization and formation of plaque on acrylic denture plates: An in vitro study | |
| CN105963237B (en) | A kind of Novel mouthwash and its preparation method and application | |
| CN105534827A (en) | Toothpaste containing lysozyme | |
| KR101778058B1 (en) | Composition for sanitation promotion of oral cavity comprising natural medicinal ingredient extract as effective component for halitosis inducing microoranism and infectious disease of mucous membrane | |
| CN109010098A (en) | Antimicrobial mouthwash and preparation method thereof | |
| CN1144579C (en) | Composition for enhancing oral hygiene | |
| Teke et al. | In vitro antimicrobial activity of some commercial toothpastes | |
| CN113197830B (en) | Toothpaste and preparation method thereof | |
| CN107073061A (en) | The prevention of dental caries and treatment oral cavity composition containing the mulberry bark extract as active component and winged euonymus extract | |
| KR20110088978A (en) | Oral composition containing herbal extract | |
| KR100519477B1 (en) | Periodontal disease prevention and treatment composition containing trichromic acid, urodessoxycholine acid derivative and milky skin extract | |
| CN107485584A (en) | A kind of oral care composition | |
| CN107362112B (en) | Gum-protecting and healing toothpaste | |
| Nair et al. | Effect of Pomegranate Juice Extract on Streptococcus mutans--An In Vitro Study. | |
| WO2024180883A1 (en) | Antifungal composition | |
| CN114681350B (en) | Detergent composition containing lysozyme | |
| RO126742B1 (en) | Toothpaste composition | |
| Goldstep | Oral rinses for a proactive intervention approach to periodontal health |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |