CN109172475A - A kind of antibacterial whitening mouthwash and preparation method thereof - Google Patents
A kind of antibacterial whitening mouthwash and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a kind of antibacterial whitening mouthwashes and preparation method thereof, antibacterial whitening mouthwash is made of antibacterial components and mouthwash matrix components, and antibacterial components are made of 0.05~0.5 part of lysozyme, 0.01~0.5 part of lauroyl arginine ethyl ester hydrochloride, 0.01~1 part of dextranase and 1~10 part of sunset abelmoschus root extract.Mouthwash matrix components include one of emulsifier, moisturizer, flavoring agent, acid-base modifier and essence or a variety of, and surplus is deionized water.Lysozyme and lauroyl arginine ethyl ester hydrochloride are dissolved in citric acid solution, stirred evenly；Prepared component is uniformly mixed with emulsifier, moisturizer, flavoring agent and essence, adjusts pH, sunset abelmoschus root extract and dextranase is added.The present invention makes there is mutually synergistic effect between natural antibacterial agent and chemical antibacterial agent, and the mouthwash produced is highly-safe, and antibacterial activity is good, can effectively prevent the generation of plaque and oral inflammation.
Description
Technical field
The invention belongs to daily chemical products technical field, a kind of antibacterial whitening mouthwash and its preparation side are particularly related to
Method.
Background technique
Chemical bactericide dichloro is all added in most of mouthrinse products with stronger bacteria resistance function currently on the market
Benzene oxygen chlorophenol etc. also known as triclosan.American researcher in 2012 delivers report on " state academy of sciences journal " and claims, for old
It is that mouse and fish muscle cell carry out the experimental results showed that, triclosan disturb an important ion channel two protein it
Between communication, weaken muscle power.The researcher of the New York State University and Arizona State University is once to New York cloth
The urine and umbilical-cord blood-sample of 184, Luke forest zone pregnant woman is chemically examined.They have found, all contain triclosan in all urine samples, surpass
It crosses in 85% urine sample and contains triclocarban.More it is a concern that more than triclosan is also contained in the umbilical-cord blood-sample of half,
This shows that the chemical component can cause to directly affect to fetus.Food and drug administration will then deliver sound in the end of the year 2010
It is bright, it is desirable that forbid antibacterial soap and shower cream containing triclosan and triclocarban to sell in shop shelf, European Union, Association of South-east Asian Nations, South Korea
Successively part disabling triclosan.
Therefore, to sum up, in order to find a kind of antibacterial material safe and free of toxic and side effects that can replace triclosan, study
Personnel have done many trials.It, can not since the antimicrobial spectrum of the one pack system antibacterial agent found in currently available technology has his own strong points
It plays to the overall protected effect of tooth, if it is possible to develop a kind of enhancing antibacterial effect, effectively inhibition plaque shape
At broad spectrum antimicrobial agent for saprodontia daily prevention and treatment have very big application value.
Summary of the invention
The present invention provides a kind of antibacterial whitening mouthwash and preparation method thereof to overcome the shortcomings of the prior art.
The present invention is achieved by the following technical solutions: a kind of antibacterial whitening mouthwash, by antibacterial components and gargles
Water-based group is grouped as, the raw material composition of antibacterial components following weight parts: 0.05~0.5 part of lysozyme, lauroyl arginine second
0.01~0.5 part of ester hydrochloride, 0.01~1 part of dextranase and 1~10 part of sunset abelmoschus root extract.
As the preferred embodiment of the present invention, the raw material of antibacterial components following weight parts is formed: lysozyme 0.05~0.1
Part, 0.05~0.1 part of lauroyl arginine ethyl ester hydrochloride, 0.06~0.4 part of dextranase and sunset abelmoschus root extract 2~4
Part.
Mouthwash matrix components include one of emulsifier, moisturizer, flavoring agent, acid-base modifier and essence or more
Kind, surplus is deionized water.
Emulsifier is rilanit special or sucrose laurate.Moisturizer is one of glycerol and propylene glycol or its group
It closes.Flavoring agent is one or more combinations of D-sorbite, xylitol, steviol glycoside and menthol.
Acid-base modifier is one or both of citric acid, malic acid, sodium citrate, natrium malicum and sodium hydroxide group
It closes.Essence is to come lemon oil or lemon extract.
A kind of preparation method of antibacterial whitening mouthwash: lysozyme and lauroyl arginine ethyl ester hydrochloride are dissolved in 8
In the citric acid solution of~12 g/L, 1~4 h is kept the temperature under conditions of temperature is 45~55 DEG C, is stirred evenly；Then it will prepare
Good component is uniformly mixed with emulsifier, moisturizer, flavoring agent and essence, and adjusting pH is 5-6.5, is eventually adding sunset abelmoschus root extraction
Object and dextranase.
The preparation method of antibacterial whitening mouthwash of the present invention specifically comprise the following steps: (1) by parts by weight be 0.05~0.5
The lysozyme and 0.05~0.5 part of lauroyl arginine ethyl ester hydrochloride of part are slowly dissolve into 10 g/L citric acid solutions,
1~2.5 h is kept the temperature under conditions of temperature is 50 DEG C, is stirred evenly, and mixed liquor is made；(2) moisturizer is added to step (1)
In in the mixed liquor for preparing, stirring and dissolving；(3) emulsifier, essence and flavoring agent are added in purified water, are dispersed with stirring molten
Solution；(4) solution obtained in above-mentioned steps (3) is added in solution made from step (2), is stirred evenly；(5) hydroxide is used
Sodium adjusts pH to 5.5-6.5 as acid-base modifier；It (6) is 1~10 part of sunset abelmoschus root extract and 0.01~1 part by parts by weight
Dextranase be added in pure water, be added after dissolution into step (4) in liquid obtained, be uniformly mixing to obtain and gargle
Water.
The present invention also provides a kind of application of antibacterial whitening mouthwash in oral cleaning and periodontosis protection.
The beneficial effects of the present invention are: the antibacterial whitening mouthwash in the present invention is using natural antibacterial agent and chemical antibacterial
Agent makes there is mutually synergistic effect between natural antibacterial agent and chemical antibacterial agent, and the mouthwash produced is highly-safe,
Antibacterial activity is good, can effectively prevent the generation of plaque and oral inflammation, and the antibacterial whitening mouthwash in the present invention has pole
The effect of good sterilization whitening effect and treatment canker sore.Mouthwash of the invention passes through antibacterial agent therein and dextran
Synergistic effect between enzyme can effectively remove intrinsic plaque, according to CIE table colour standard, after mouthwash of the present invention
Tooth L value be higher by control 12.5%, antibacterial, tooth-whitening can be played, permanent tooth, total care oral cavity, keep dental health
Effect, sunset abelmoschus root extract have the function of that alleviation canker sore symptom, the present invention are gargled using what safe antibacterial agent was prepared
Water has no toxic side effect, and can effectively inhibit the breeding of the microorganisms such as bacterium and the fungi in oral cavity.
Specific embodiment
Below in conjunction with specific embodiment, the present invention is described in detail.
The invention discloses a kind of antibacterial whitening mouthwashes, are made of antibacterial components and mouthwash matrix components, antibacterial
The raw materials of component following weight parts forms: 0.05~0.5 part of lysozyme, 0.01~0.5 part of lauroyl arginine ethyl ester hydrochloride,
0.01~1 part and 1~10 part of sunset abelmoschus root extract of dextranase.As the preferred embodiment of the present invention, under antibacterial components
State the raw material composition of parts by weight: 0.05~0.1 part of lysozyme, 0.05~0.1 part of lauroyl arginine ethyl ester hydrochloride, dextrose
0.06~0.4 part and 2~4 parts of sunset abelmoschus root extract of acid anhydride enzyme.
Mouthwash matrix components include one of emulsifier, moisturizer, flavoring agent, acid-base modifier and essence or more
Kind, surplus is deionized water.Emulsifier is rilanit special or sucrose laurate.Moisturizer is one in glycerol and propylene glycol
Kind or combinations thereof.Flavoring agent is one or more combinations of D-sorbite, xylitol, steviol glycoside and menthol.Acid-base accommodation
Agent is the combination of one or both of citric acid, malic acid, sodium citrate, natrium malicum and sodium hydroxide.Essence is to carry out lemon oil
Or lemon extract.
The preparation method of antibacterial whitening mouthwash of the present invention specifically comprise the following steps: (1) by parts by weight be 0.05~0.5
The lysozyme and 0.05~0.5 part of lauroyl arginine ethyl ester hydrochloride of part are slowly dissolve into 10 g/L citric acid solutions,
1~2.5 h is kept the temperature under conditions of temperature is 50 DEG C, is stirred evenly, and mixed liquor is made；(2) moisturizer is added to step (1)
In in the mixed liquor for preparing, stirring and dissolving；(3) emulsifier, essence and flavoring agent are added in purified water, are dispersed with stirring molten
Solution；(4) solution obtained in above-mentioned steps (3) is added in solution made from step (2), is stirred evenly；(5) hydroxide is used
Sodium adjusts pH to 5.5-6.5 as acid-base modifier；It (6) is 1~10 part of sunset abelmoschus root extract and 0.01~1 part by parts by weight
Dextranase be added in pure water, be added after dissolution into step (4) in liquid obtained, be uniformly mixing to obtain and gargle
Water.
It is that antibacterial whitening mouthwash of the present invention uses evaluation method is as follows:
(1) evaluation method of minimal inhibitory concentration MIC:
The streptococcus mutans ATCC25135 of oral cavity common pathogen, Leuconostoc mesenteroides, staphylococcus aureus are placed in meat soup
It cultivates on culture medium for 24 hours, with oese picking representative configuration for trying bacterium colony, is inoculated in 5mL LB fluid nutrient medium, 37
DEG C, 200r/min, 12~16h of culture to logarithmic growth phase.Appropriate bacterium solution is taken, extremely with LB fluid nutrient medium adjustment bacteria concentration
105CFU/mL.Minimal inhibitory concentration MIC is measured.Under aseptic condition, successively by step 1 component of each embodiment press than
Dilution.The 1st column of sterile 96 orifice plate are added sequentially to from low to high by dilution to the 11st column, every 50 μ L of hole, the 12nd is classified as sun
Property control, add equivalent sterile water.Subsequent every hole adds 50 μ L bacterium solutions, and sealing mixes.At this point, the 1st hole to the 11st hole is gargled
The whole mass concentration of water is respectively that 3200,1600,800,400,200,100,50,25,12.5,6.25 and 3.125 μ g/mL(are pressed
Lotion quality).OD when 0h is measured with microplate reader630 nm96 orifice plates, are then placed in 37 DEG C of incubators and cultivate for 24 hours by value, then
Secondary measurement OD630 nmValue.By comparison 0 h with for 24 hours when bacterium solution OD630 nm Value, determines that different embodiments cause each main oral
The MIC of germ measures fungistatic effect with this.
(2) bacteriostasis rate:
By the common indicator bacteria Candida albicans ATCC10231 of daily chemical products, escherichia coli CMCC(B) 44103 and golden yellow
Color staphylococcus CMCC(B) 26003 bacterium are placed on potato dextrose medium or broth bouillon and cultivate for 24 hours, use oese
Picking representative configuration for try bacterium colony, be inoculated in 5mL PDB or LB liquid medium, 37 DEG C, 200r/min, culture 12~
16h is to logarithmic growth phase.9mL mouthwash is added in sterile test tube, using 9mL physiological saline as control；In above-mentioned test tube
Be added 1mL activation after bacteria suspension, make its final concentration of 1 × 104~106cfu/mL；20 min of timing, pour plate measure bacterium
Fall number；The culture medium of solidification is placed in incubator culture, bacterium is cultivated for 24 hours at 37 DEG C, and fungi cultivates 72 h at 28 DEG C；Meter
Calculate bacteriostasis rate:X- bacteriostasis rate %；X=(A-B)/A×100%；A- control sample average colony number；B- subject sample average bacterium
Fall number；Bacteriostasis rate >=50%~90%, product have bacteriostasis, bacteriostasis rate >=90%, and product has stronger bacteriostasis.
Embodiment 1: according to following quality proportioning prepare raw material: glycerol 3%, propylene glycol 2%, essence 0.35%, citric acid 1%,
Sodium hydroxide 0.5%, sucrose laurate 0.015%, Cremophor RH40 0.1%, xylitol 0.2%, D-sorbite
0.2%, menthol 0.045%, lysozyme 0.08%, lauroyl arginine ethyl ester hydrochloride 0.1%, dextranase 0.1%, yellow another name for Sichuan Province
Certain herbaceous plants with big flowers extract 3% and purified water 89.31%.
Mouthwash is prepared according to the following steps in the present invention: (1) preparing antibacterial component: by 0.08 part of lysozyme and 0.1 part month
Osmanthus acyl arginine ethyl ester hydrochloride is dissolved in acid-base modifier, and 1 part of citric acid, which is dissolved in, to be prepared in 20 parts of purified waters
Acidolysis regulator, 50 DEG C of heat preservation 2h, stirs evenly；(2) by 0.1 part of rilanit special, 0.015 part of sucrose laurate and 0.05
Part menthol is added in the solution being made of 3 parts of glycerol, 2 parts of propylene glycol, and 50 DEG C of heat preservation 2h are stirred evenly；(3) by 0.35 part
Essence, 0.2 part of xylitol and 0.2 part of D-sorbite are added in 20 parts of purified waters, are dispersed with stirring dissolution；(4) by above-mentioned steps (3)
In solution be added step (2) solution in, stir evenly；(5) solution of above-mentioned steps (1) is added to the liquid of step (4)
In, it stirs evenly；0.5 part of sodium hydroxide is used to adjust pH to 5.5-6.5 as acid-base modifier；(6) by 0.1 part of dextran
Enzyme and 3 parts of sunset abelmoschus root extracts are added in 49.41 parts of pure water, are added after dissolution into the liquid of step (5), are stirred evenly
To mouthwash.
Reference examples 1: specific embodiment is to be added without lysozyme in step (1), not be added with embodiment 1, difference
Lysozyme ratio is in step (1) by purified water polishing.
Reference examples 2: specific embodiment is to be added without lauroyl arginine ethyl ester in step (1) with embodiment 1, difference
Hydrochloride, the lauroyl arginine ethyl ester hydrochloride ratio not being added is in step (1) by purified water polishing.
Reference examples 3: with embodiment 1, difference is to be added without dextranase in step (6) specific embodiment, not plus
The dextranase ratio entered is in step (6) by purified water polishing.
Reference examples 4: specific embodiment is distinguished with embodiment 1 and is to be added without sunset abelmoschus root extract in step (6), not
The sunset abelmoschus root extract ratio of addition is in step (6) by purified water polishing.
Reference examples 5: with embodiment 1, difference is to be added without lysozyme and lauroyl essence in step (1) specific embodiment
Propylhomoserin carbethoxy hydrochloride adds 0.3 part of potassium sorbate, and the said components ratio not being added is by purified water polishing.
Table 1: the formula rate of mouthwash by mass
| Mouthwash formula (%) | Embodiment 1 | Reference examples 1 | Reference examples 2 | Reference examples 3 | Reference examples 4 | Reference examples 5 |
| Lysozyme | 0.08 | 0 | 0.08 | 0.08 | 0.08 | 0 |
| Lauroyl arginine ethyl ester hydrochloride | 0.1 | 0.1 | 0 | 0.1 | 0.1 | 0 |
| Sunset abelmoschus root extract | 3 | 3 | 3 | 3 | 0 | 3 |
| Dextranase | 0.1 | 0.1 | 0.1 | 0 | 0.1 | 0.1 |
| Potassium sorbate | 0 | 0 | 0 | 0 | 0 | 0.3 |
| Propylene glycol | 2 | 2 | 2 | 2 | 2 | 2 |
| Glycerol | 3 | 3 | 3 | 3 | 3 | 3 |
| Rilanit special | 0.1 | 0.1 | 0.1 | 0.1 | 0.1 | 0.1 |
| Sucrose laurate | 0.015 | 0.015 | 0.015 | 0.015 | 0.015 | 0.015 |
| D-sorbite | 0.2 | 0.2 | 0.2 | 0.2 | 0.2 | 0.2 |
| Xylitol | 0.2 | 0.2 | 0.2 | 0.2 | 0.2 | 0.2 |
| Menthol | 0.045 | 0.045 | 0.045 | 0.045 | 0.045 | 0.045 |
| Essence | 0.35 | 0.35 | 0.35 | 0.35 | 0.35 | 0.35 |
| Citric acid | 1 | 1 | 1 | 1 | 1 | 1 |
| Sodium hydroxide | 0.5 | 0.5 | 0.5 | 0.5 | 0.5 | 0.5 |
| Purified water | 89.31 | 89.39 | 89.41 | 89.41 | 92.31 | 89.19 |
Table 2: minimal inhibitory concentration MIC ※ (ppm) experimental result
The weight of fungicide is in ※ minimal inhibitory concentration with the calculating of solid powder weight.
Table 3: bacteriostasis rate experimental result
| Microorganism | Embodiment 1 | Reference examples 1 | Reference examples 2 | Reference examples 3 | Reference examples 4 | Reference examples 5 |
| Escherichia coli | >90 | 80.3 | 45.9 | >90 | >90 | 45.3 |
| Staphylococcus aureus | >90 | 75.4 | 70 | >90 | >90 | 46.7 |
| Candida albicans | >90 | 75 | 50 | >90 | >90 | 56.8 |
The embodiment of the present invention 1 is shown compared with reference examples 1-5 by table 2 as the result is shown, antibacterial system is by lysozyme, lauroyl
The antibacterial whitening mouthwash of arginine ethyl ester hydrochloride composition can significantly reduce minimal inhibitory concentration, compared with exclusive use,
Synergistic effect can be played, for bactericidal effect compared with commercially available common antibacterial agent potassium sorbate, effect is more excellent.
Finally it should be noted that the above content is merely illustrative of the technical solution of the present invention, rather than the present invention is protected
The limitation of range, the simple modification or equivalent replacement that those skilled in the art carry out technical solution of the present invention,
All without departing from the spirit and scope of technical solution of the present invention.
Claims (10)
1. a kind of antibacterial whitening mouthwash, it is characterised in that: the antibacterial whitening mouthwash is by antibacterial components and water-based of gargling
Group is grouped as, the raw material composition of the antibacterial components following weight parts: 0.05~0.5 part of lysozyme, lauroyl arginine ethyl ester
0.01~0.5 part of hydrochloride, 0.01~1 part of dextranase and 1~10 part of sunset abelmoschus root extract.
2. a kind of antibacterial whitening mouthwash according to claim 1, it is characterised in that: the antibacterial components following weight parts
Raw material composition: 0.05~0.1 part of lysozyme, 0.05~0.1 part of lauroyl arginine ethyl ester hydrochloride, dextranase 0.06
~0.4 part and 2~4 parts of sunset abelmoschus root extract.
3. a kind of antibacterial whitening mouthwash according to claim 1, it is characterised in that: the mouthwash matrix components include
One of emulsifier, moisturizer, flavoring agent, acid-base modifier and essence are a variety of, and surplus is deionized water.
4. a kind of antibacterial whitening mouthwash according to claim 1,2 or 3, it is characterised in that: the emulsifier is hydrogenation
Castor oil or sucrose laurate.
5. a kind of antibacterial whitening mouthwash according to claim 1,2 or 3, it is characterised in that: the moisturizer is glycerol
With one of propylene glycol or combinations thereof.
6. a kind of antibacterial whitening mouthwash according to claim 1,2 or 3, it is characterised in that: the flavoring agent is sorb
One or more combinations of sugar alcohol, xylitol, steviol glycoside and menthol.
7. a kind of antibacterial whitening mouthwash according to claim 1,2 or 3, it is characterised in that: the acid-base modifier is
The combination of one or both of citric acid, malic acid, sodium citrate, natrium malicum and sodium hydroxide.
8. a kind of antibacterial whitening mouthwash according to claim 1,2 or 3, it is characterised in that: the essence is to carry out lemon oil
Or lemon extract.
9. a kind of preparation method of antibacterial whitening mouthwash, it is characterised in that: the preparation method of the antibacterial whitening mouthwash
Are as follows: lysozyme and lauroyl arginine ethyl ester hydrochloride are dissolved in the citric acid solution of 8~12 g/L, temperature be 45~
1~4 h is kept the temperature under conditions of 55 DEG C, is stirred evenly；Then by prepared component and emulsifier, moisturizer, flavoring agent and perfume (or spice)
Essence is uniformly mixed, and adjusting pH is 5-6.5, is eventually adding sunset abelmoschus root extract and dextranase.
10. a kind of preparation method of antibacterial whitening mouthwash according to claim 9, it is characterised in that: the antibacterial beauty
The preparation method of white mouthwash specifically comprises the following steps:
It (1) is that 0.05~0.5 part of lysozyme and 0.05~0.5 part of lauroyl arginine ethyl ester hydrochloride are slow by parts by weight
It is dissolved in 10 g/L citric acid solutions, 1~2.5 h is kept the temperature under conditions of temperature is 50 DEG C, is stirred evenly, mixing is made
Liquid；
(2) moisturizer is added in the mixed liquor prepared into step (1), stirring and dissolving；
(3) emulsifier, essence and flavoring agent are added in purified water, are dispersed with stirring dissolution；
(4) solution obtained in above-mentioned steps (3) is added in solution made from step (2), is stirred evenly；
(5) sodium hydroxide is used to adjust pH to 5.5-6.5 as acid-base modifier；
It (6) is that 1~10 part of sunset abelmoschus root extract and 0.01~1 part of dextranase are added in pure water by parts by weight, it is molten
It is added after solution into step (4) in liquid obtained, is uniformly mixing to obtain mouthwash.
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112274445A (en) * | 2020-12-21 | 2021-01-29 | 广东微笑科技有限公司 | Gingiva protecting mouthwash containing arginine and preparation method thereof |
| CN112972661A (en) * | 2021-04-26 | 2021-06-18 | 立康荣健(北京)生物医药科技有限公司 | Antibacterial composition, preparation and application thereof |
| CN113317327A (en) * | 2020-02-28 | 2021-08-31 | 中粮营养健康研究院有限公司 | Bactericidal virucidal enzyme preparation composition and application thereof |
| CN114306166A (en) * | 2022-01-13 | 2022-04-12 | 南京昂谷医药科技有限公司 | Preparation and application of wogonin mouthwash |
| CN114848803A (en) * | 2021-01-20 | 2022-08-05 | 中粮营养健康研究院有限公司 | Bio-based disinfectant and application thereof |
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| EP3348253A1 (en) * | 2017-01-11 | 2018-07-18 | Lacer, S.A. | Low-alcohol oral care compositions comprising ethyl lauroyl arginate |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN113317327A (en) * | 2020-02-28 | 2021-08-31 | 中粮营养健康研究院有限公司 | Bactericidal virucidal enzyme preparation composition and application thereof |
| CN112274445A (en) * | 2020-12-21 | 2021-01-29 | 广东微笑科技有限公司 | Gingiva protecting mouthwash containing arginine and preparation method thereof |
| CN114848803A (en) * | 2021-01-20 | 2022-08-05 | 中粮营养健康研究院有限公司 | Bio-based disinfectant and application thereof |
| CN112972661A (en) * | 2021-04-26 | 2021-06-18 | 立康荣健(北京)生物医药科技有限公司 | Antibacterial composition, preparation and application thereof |
| CN114306166A (en) * | 2022-01-13 | 2022-04-12 | 南京昂谷医药科技有限公司 | Preparation and application of wogonin mouthwash |
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