CN110123696A - Preparation method of composite preservative for natural volcanic mud mask - Google Patents
Preparation method of composite preservative for natural volcanic mud mask Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/965—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of inanimate origin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/52—Stabilizers
- A61K2800/524—Preservatives
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Abstract
A preparation method of a compound preservative for a natural volcanic slime facial mask relates to the technical field of compound preservative preparation. The invention aims to solve the problems that the existing preservative can not effectively kill (inhibit) bacteria, mould and yeast and some components of the excessive preservative are harmful to people. The method comprises the following steps: adding 1, 3-propylene glycol, phenoxyethanol and chlorphenesin into a stirring tank 1, and stirring to obtain a mixed solution A; secondly, adding 1, 3-propylene glycol, thyme extract and elderberry extract into the stirring tank 2, and stirring to obtain a mixed solution B; and thirdly, mixing the mixed liquor A obtained in the first step with the mixed liquor B obtained in the second step, and stirring to obtain the compound preservative for the natural volcanic mud mask. The invention can obtain the preparation method of the compound preservative for the natural volcanic slime mask.
Description
Technical field
The present invention relates to compound preservative preparation technical fields.
Background technique
Natural volcanic slurry mask product, using a kind of natural volcanic slurry as primary raw material, this raw material is derived from China Dark dragon
It is that eruption through operation of nature is gathered in low-lying place, by centuries in UNESCO Geopark circle of the Wudalianchi Jiang Sheng
The immersion of table and underground water and formed, sludge is chronically in wetland peat layer enclosed environment below, internal microbe quantity
Amount is more and type is abundant, survive strain and gemma better resistance.
Previous natural volcanic slurry mask product uses single preservative in terms of aseptic technic, but in mask product
Shelf life and use process in detect a large amount of bacteriums, mould and yeast-infection, these pollutants lead to natural volcanic slurry
Mask product is off quality；And some ingredients of preservative can cause the diseases such as cosmetics type dermatitis to a certain extent
Disease is safe to the human body to have an impact.Therefore, existing preservative has been unsatisfactory for product microorganism limitation requirement.
Summary of the invention
The invention aims to solve existing preservative cannot effectively kill bacterium, mould and saccharomycete
The problem of some ingredients of (inhibition) and excessive preservative are pernicious to people, and a kind of natural volcanic slurry facial mask is provided with compound
The preparation method of preservative.
A kind of preparation method of natural volcanic slurry facial mask compound preservative is completed according to the following steps:
One, 22.5 parts~27.5 parts 1,3-PDs of addition, 1 part~3 parts Phenoxyethanols and 1 part~4 parts into agitator tank 1
Chlorphenesin stirs 60min~90min under the conditions of 75 DEG C~80 DEG C of temperature, with the revolving speed of 80r/min~90r/min, obtains
To mixed liquor A；
Two, 22.5 parts~27.5 parts 1,3-PDs, 20 parts~30 parts thyme extracts and 15 are added into agitator tank 2
Part~20 parts of elderberry extracts stir under the conditions of 75 DEG C~80 DEG C of temperature, with the revolving speed of 80r/min~90r/min
30min~60min obtains mixed liquid B；
Three, the mixed liquor A that step 1 obtains is mixed with the mixed liquid B that step 2 obtains, and at 75 DEG C~80 DEG C
60min~90min is stirred under the conditions of temperature, with the revolving speed of 80r/min~90r/min, obtains a kind of natural volcanic slurry facial mask
Use compound preservative.
Beneficial effects of the present invention:
One, a kind of natural volcanic slurry facial mask prepared by the present invention is in compound preservative ingredient, Phenoxyethanol and chlorobenzene
Sweet ether is broad spectrum antimicrobial agent, and wherein Phenoxyethanol is stronger to bacterial resistance, and Chlorphenesin is true to aspergillus niger, Candida albicans etc.
Bacterium bactericidal effect is more preferable.In biological preservative, the thyme and elder plant being related to are that Wudalianchi Volcanic dirt area is raw
Long breeding, thyme and elderberry extract are plant source suppression (killing) microbial inoculum, and thyme extract is thyme essential oil, main
Wanting ingredient is Thymol and perfume Jing Xiang phenol, and the thyme essential oil of different extracting concentrations is to staphylococcus aureus, withered grass gemma
The bacteriums such as bacillus, Escherichia coli have different degrees of inhibiting effect, and fungistatic effect is fine, and elderberry extract is mainly derived from
Leaf and stem branch, flavone compound and Berberine hydrochloride isoreactivity substance are fine to the growth inhibitory effect of hypha,hyphae.
Two, a kind of preparation method of natural volcanic slurry facial mask compound preservative of the present invention is chemical preservative and more
Kind plant source suppression (killing) bacterium ingredient is combined, and has efficient Antimicrobial preservative performance, each component is to skin in compound preservative
It is nontoxic, non-stimulated, non-corrosive, and the natural scents and skin-care effect of cosmetics can be improved.
The present invention can get a kind of preparation method of natural volcanic slurry facial mask compound preservative.
Specific embodiment
Specific embodiment 1: a kind of preparation method of natural volcanic slurry facial mask compound preservative of present embodiment,
It completes according to the following steps:
One, 22.5 parts~27.5 parts 1,3-PDs of addition, 1 part~3 parts Phenoxyethanols and 1 part~4 parts into agitator tank 1
Chlorphenesin stirs 60min~90min under the conditions of 75 DEG C~80 DEG C of temperature, with the revolving speed of 80r/min~90r/min, obtains
To mixed liquor A；
Two, 22.5 parts~27.5 parts 1,3-PDs, 20 parts~30 parts thyme extracts and 15 are added into agitator tank 2
Part~20 parts of elderberry extracts stir under the conditions of 75 DEG C~80 DEG C of temperature, with the revolving speed of 80r/min~90r/min
30min~60min obtains mixed liquid B；
Three, the mixed liquor A that step 1 obtains is mixed with the mixed liquid B that step 2 obtains, and at 75 DEG C~80 DEG C
60min~90min is stirred under the conditions of temperature, with the revolving speed of 80r/min~90r/min, obtains a kind of natural volcanic slurry facial mask
Use compound preservative.
Present embodiment the utility model has the advantages that
One, a kind of natural volcanic slurry facial mask of present embodiment preparation is in compound preservative ingredient, Phenoxyethanol with
Chlorphenesin is broad spectrum antimicrobial agent, and wherein Phenoxyethanol is stronger to bacterial resistance, and Chlorphenesin is to aspergillus niger, Candida albicans
Equal fungies bactericidal effect is more preferable.In biological preservative, the thyme and elder plant being related to are Wudalianchi Volcanic dirt
Area's growth reproduction, thyme and elderberry extract are plant source suppression (killing) microbial inoculum, and thyme extract is thyme essence
Oil, main component are Thymol and perfume Jing Xiang phenol, and the thyme essential oil of different extracting concentrations is to staphylococcus aureus, withered grass
The bacteriums such as bacillus, Escherichia coli have different degrees of inhibiting effect, and fungistatic effect is fine, and elderberry extract is main
Be derived from leaf and stem branch, flavone compound and Berberine hydrochloride isoreactivity substance to the growth inhibitory effect of hypha,hyphae very
It is good.
Two, a kind of preparation method of natural volcanic slurry facial mask compound preservative of present embodiment, is chemical preservative
It is combined with various plants source suppression (killing) bacterium ingredient, there is efficient Antimicrobial preservative performance, each component pair in compound preservative
Skin is nontoxic, non-stimulated, non-corrosive, and can improve the natural scents and skin-care effect of cosmetics.
Specific embodiment 2: the differences between this implementation mode and the specific implementation mode are that: in step 1 into agitator tank 1
25 parts of 1,3-PDs, 1.7 parts of Phenoxyethanols and 2 parts of Chlorphenesins are added.
Other steps are same as the specific embodiment one.
Specific embodiment 3: present embodiment is with specific embodiment one or two differences: at 77 DEG C in step 1
Temperature under the conditions of, 75min stirred with the revolving speed of 85r/min, obtain mixed liquor A.
Other steps are the same as one or two specific embodiments.
Specific embodiment 4: one of present embodiment and specific embodiment one to three difference are: institute in step 2
The thyme extract stated includes Thymol, perfume Jing Xiang phenol and p-cymene, and the mass fraction of other compositions is no more than 15%.
Other steps are identical as specific embodiment one to three.
Specific embodiment 5: one of present embodiment and specific embodiment one to four difference are: Thymol, perfume (or spice)
The mass ratio of Jing Xiang phenol and p-cymene is 35~55:15~30:10~20.
Other steps are identical as specific embodiment one to four.
Specific embodiment 6: one of present embodiment and specific embodiment one to five difference are: institute in step 2
The elderberry extract stated includes flavone compound, Berberine hydrochloride and polysaccharide, and the mass fraction of other compositions is no more than
18%.
Other steps are identical as specific embodiment one to five.
Specific embodiment 7: one of present embodiment and specific embodiment one to six difference are: flavonoid
The mass ratio of object, Berberine hydrochloride and polysaccharide is 35~50:15~30:25~35.
Other steps are identical as specific embodiment one to six.
Specific embodiment 8: one of present embodiment and specific embodiment one to seven difference are: in step 2 to
25 parts of 1,3-PDs, 23 parts of thyme extracts and 17 parts of elderberry extracts are added in agitator tank 2.
Other steps are identical as specific embodiment one to seven.
Specific embodiment 9: one of present embodiment and specific embodiment one to eight difference are: in step 2
45min is stirred under the conditions of 76 DEG C of temperature, with the revolving speed of 85r/min, obtains mixed liquid B.
Other steps are identical as specific embodiment one to eight.
Specific embodiment 10: one of present embodiment and specific embodiment one to nine difference are: will in step 3
The mixed liquor A that step 1 obtains is mixed with the mixed liquid B that step 2 obtains, and under the conditions of 77 DEG C of temperature, with 85r/min
Revolving speed stir 70min, obtain a kind of natural volcanic slurry facial mask compound preservative.
Other steps are identical as specific embodiment one to nine.
Beneficial effects of the present invention are verified using following embodiment:
Embodiment one: a kind of preparation method of natural volcanic slurry facial mask compound preservative is completed according to the following steps:
One, 25 parts of 1,3-PDs, 1.7 parts of Phenoxyethanols and 2 parts of Chlorphenesins are added into agitator tank 1, at 77 DEG C
75min is stirred under the conditions of temperature, with the revolving speed of 85r/min, obtains mixed liquor A；
Two, 25 parts of 1,3-PDs, 23 parts of thyme extracts and 17 parts of elderberry extracts are added into agitator tank 2,
45min is stirred under the conditions of 76 DEG C of temperature, with the revolving speed of 85r/min, obtains mixed liquid B；
Thyme extract described in step 2 includes Thymol, perfume Jing Xiang phenol and p-cymene, other compositions
Mass fraction is no more than 15%, and the mass ratio of Thymol, perfume Jing Xiang phenol and p-cymene is 50:20:15；Described in step 2
Elderberry extract include flavone compound, Berberine hydrochloride and polysaccharide, the mass fraction of other compositions is no more than 18%,
The mass ratio of flavone compound, Berberine hydrochloride and polysaccharide is 40:17:25；
Three, the mixed liquor A that step 1 obtains is mixed with the mixed liquid B that step 2 obtains, and in 77 DEG C of temperature strip
70min is stirred under part, with the revolving speed of 85r/min, obtains a kind of natural volcanic slurry facial mask compound preservative.
Embodiment two: the test of antimicrobial preservation challenge is completed according to the following steps:
One, a kind of natural volcanic slurry obtained in ingredient used in natural volcanic slurry facial mask and embodiment one will be prepared
Facial mask is added in agitator tank with compound preservative, is stirred 60min under the conditions of 75 DEG C of temperature, with the revolving speed of 85r/min, is obtained
To mask product A to be measured；
Prepared in step 1 ingredient used in natural volcanic slurry facial mask addition total amount and a kind of natural volcanic slurry facial mask
It is 9:1 with the mass ratio of compound preservative；
Two, with reference to Microbial Challenge test method in United States Pharmacopeia (USP), in the mask product to be measured that step 1 obtains
Microbial bacteria suspension is added in A, respectively at 0 day, 7 days, 14 days and 28 days, with the survival feelings of colony counting method detection microorganism
Condition, and then judge a kind of anti-corrosion effect of natural volcanic slurry facial mask compound preservative, testing result is shown in Table 1；
The ratio of the volume of the quality and microbial bacteria suspension of mask product A to be measured is 20g:0.15mL in step 2, described
Microbial bacteria suspension in be made of bacterium bacteria suspension and mould bacteria suspension, the concentration of bacterium bacteria suspension is about 1 × 108cfu/
ML, the concentration of mould bacteria suspension are about 1 × 108cfu/mL。
Comparative example two: the test of antimicrobial preservation challenge is completed according to the following steps:
One, ingredient used in natural volcanic slurry facial mask will be prepared and existing preservative is added in agitator tank, 75
DEG C temperature under the conditions of, 60min stirred with the revolving speed of 85r/min, obtain mask product B to be measured；
Existing preservative is that ethyl hydroxy benzoate, methylisothiazolinone and three kinds of methylchloroisothiazandnone are anti-in step 1
Rotten agent is used in combination, and the mass ratio of ethyl hydroxy benzoate, methylisothiazolinone and methylchloroisothiazandnone is 0.1:0.0009:
0.0001, the addition total amount of ingredient used in natural volcanic slurry facial mask is prepared in step 1 and the mass ratio of existing preservative is
100:0.101；
Two, with reference to Microbial Challenge test method in United States Pharmacopeia (USP), in the mask product to be measured that step 1 obtains
Microbial bacteria suspension is added in B, respectively at 0 day, 7 days, 14 days and 28 days, with the survival feelings of colony counting method detection microorganism
Condition, and then judge the anti-corrosion effect of existing preservative, testing result is shown in Table 1；
The ratio of the volume of the quality and microbial bacteria suspension of mask product B to be measured is 20g:0.15mL in step 2, described
Microbial bacteria suspension in be made of bacterium bacteria suspension and mould bacteria suspension, the concentration of bacterium bacteria suspension is about 1 × 108cfu/
ML, the concentration of mould bacteria suspension are about 1 × 108cfu/mL。
Test microbes strain in embodiment two and comparative example two:
Bacterium: Escherichia coli (ATCC NO.8739), staphylococcus aureus (ATCC NO.6538), pseudomonas aeruginosa
(ATCC NO.9027)；
Mould and saccharomycete: candida albicans (ATCC NO.10231), aspergillus niger (ATCC NO.16404), special aspergillus
(contamination of products object), Fusarium solani (contamination of products object), Aspergillus sojae (contamination of products object), aspergillus oryzae (contamination of products object).
Contamination of products object refers to the microorganism that the mask product of former preservative system formulation pollutes during shelf.
Table 1 be mask product A to be measured and mask product B to be measured add after microbial bacteria suspension respectively 0 day, 7 days, 14 days and
28 days, with the survival condition for the microorganism that colony counting method detects；
As shown in table 1, according to the requirement of United States Pharmacopeia (USP) detection method, initial bacteria count is compared in count of bacteria in 14 days
Reduce logarithm not less than 2.0 (log reduction > 5.11 in embodiment two；Log reduction 4.07 in comparative example two),
14 days and 28 days bacterial populations do not increase that (bacterial population does not increase in embodiment two；28 days bacterial populations increase in comparative example two), 7
It, the yeast and mold count of 14 days and 28 days be below initial count (significantly lower than initial number in embodiment two；Comparison
It is higher than initial count within 28 days in embodiment two).Experiments have shown that: existing preservative (kills the inhibition of bacterium, mould and saccharomycete
Go out) it is ineffective；A kind of natural volcanic slurry facial mask compound preservative obtained in embodiment one is to bacterium, mould and yeast
Bacterium has very strong inhibition (killing) effect.
Table 1
Embodiment three: the limit value of Cosmetics microorganism index is examined, and is completed according to the following steps:
One, a kind of natural volcanic slurry obtained in ingredient used in natural volcanic slurry facial mask and embodiment one will be prepared
Facial mask is added in agitator tank with compound preservative, is stirred 60min under the conditions of 75 DEG C of temperature, with the revolving speed of 85r/min, is obtained
To mask product to be measured；
Prepared in step 1 ingredient used in natural volcanic slurry facial mask addition total amount and a kind of natural volcanic slurry facial mask
It is 9:1 with the mass ratio of compound preservative；
Two, according to the limit value of Cosmetics microorganism index in " cosmetics safety technical specification " (2015 editions), to step 1
Obtained in mask product to be measured total plate count, yeast and mold sum, heat-resisting coliform, staphylococcus aureus with
And pseudomonas aeruginosa is tested.
Table 2 is to total plate count, yeast and mold sum, heat-resisting coliform, golden yellow Portugal in mask product to be measured
The result that grape coccus and pseudomonas aeruginosa are tested；
As shown in table 2, microorganism meets " cosmetics safety technical specification " in mask product to be measured obtained in step 1
The limit value of Cosmetics microorganism index in (2015 editions), a kind of natural volcanic slurry facial mask added in mask product to be measured is with multiple
It is fine to inhibition (killing) effect of microorganism to close preservative.
Table 2
Embodiment the utility model has the advantages that
One, in a kind of natural volcanic slurry facial mask compound preservative ingredient prepared in embodiment one, Phenoxyethanol with
Chlorphenesin is broad spectrum antimicrobial agent, and wherein Phenoxyethanol is stronger to bacterial resistance, and Chlorphenesin is to aspergillus niger, Candida albicans
Equal fungies bactericidal effect is more preferable.In biological preservative, the thyme and elder plant being related to are Wudalianchi Volcanic dirt
Area's growth reproduction, thyme and elderberry extract are plant source suppression (killing) microbial inoculum, and thyme extract is thyme essence
Oil, main component are Thymol and perfume Jing Xiang phenol, and the thyme essential oil of different extracting concentrations is to staphylococcus aureus, withered grass
The bacteriums such as bacillus, Escherichia coli have different degrees of inhibiting effect, and fungistatic effect is fine, and elderberry extract is main
Be derived from leaf and stem branch, flavone compound and Berberine hydrochloride isoreactivity substance to the growth inhibitory effect of hypha,hyphae very
It is good.
Two, a kind of preparation method of natural volcanic slurry facial mask compound preservative, is chemical preservative and various plants
Source suppression (killing) bacterium ingredient is combined, and has efficient Antimicrobial preservative performance, and each component is nontoxic to skin in compound preservative, nothing
It stimulates, is non-corrosive, and the natural scents and skin-care effect of cosmetics can be improved.
Claims (10)
1. a kind of preparation method of natural volcanic slurry facial mask compound preservative, it is characterised in that the preparation method presses following step
It is rapid to complete:
One, 22.5 parts~27.5 parts 1,3-PDs, 1 part~3 parts Phenoxyethanols and 1 part~4 parts chlorobenzenes are added into agitator tank 1
Sweet ether stirs 60min~90min under the conditions of 75 DEG C~80 DEG C of temperature, with the revolving speed of 80r/min~90r/min, is mixed
Close liquid A；
Two, be added into agitator tank 2 22.5 parts~27.5 parts 1,3-PDs, 20 parts~30 parts thyme extracts and 15 parts~
20 parts of elderberry extracts, under the conditions of 75 DEG C~80 DEG C of temperature, with the revolving speed of 80r/min~90r/min stirring 30min~
60min obtains mixed liquid B；
Three, the mixed liquor A that step 1 obtains is mixed with the mixed liquid B that step 2 obtains, and in 75 DEG C~80 DEG C of temperature
Under the conditions of, 60min~90min stirred with the revolving speed of 80r/min~90r/min, obtain a kind of natural volcanic slurry facial mask with multiple
Close preservative.
2. a kind of preparation method of natural volcanic slurry facial mask compound preservative according to claim 1, feature exist
25 parts of 1,3-PDs, 1.7 parts of Phenoxyethanols and 2 parts of Chlorphenesins are added into agitator tank 1 in step 1.
3. a kind of preparation method of natural volcanic slurry facial mask compound preservative according to claim 1, feature exist
75min is stirred under the conditions of 77 DEG C of temperature, with the revolving speed of 85r/min in step 1, obtains mixed liquor A.
4. a kind of preparation method of natural volcanic slurry facial mask compound preservative according to claim 1, feature exist
Thyme extract described in step 2 includes Thymol, perfume Jing Xiang phenol and p-cymene, the quality point of other compositions
Number is no more than 15%.
5. a kind of preparation method of natural volcanic slurry facial mask compound preservative according to claim 4, feature exist
In Thymol, perfume Jing Xiang phenol and p-cymene mass ratio be 35~55:15~30:10~20.
6. a kind of preparation method of natural volcanic slurry facial mask compound preservative according to claim 1, feature exist
Elderberry extract described in step 2 includes flavone compound, Berberine hydrochloride and polysaccharide, the quality of other compositions
Score is no more than 18%.
7. a kind of preparation method of natural volcanic slurry facial mask compound preservative according to claim 6, feature exist
In flavone compound, Berberine hydrochloride and polysaccharide mass ratio be 35~50:15~30:25~35.
8. a kind of preparation method of natural volcanic slurry facial mask compound preservative according to claim 1, feature exist
25 parts of 1,3-PDs, 23 parts of thyme extracts and 17 parts of elderberry extracts are added into agitator tank 2 in step 2.
9. a kind of preparation method of natural volcanic slurry facial mask compound preservative according to claim 1, feature exist
45min is stirred under the conditions of 76 DEG C of temperature, with the revolving speed of 85r/min in step 2, obtains mixed liquid B.
10. a kind of preparation method of natural volcanic slurry facial mask compound preservative according to claim 1, feature exist
The mixed liquor A that step 1 obtains is mixed with the mixed liquid B that step 2 obtains in step 3, and in 77 DEG C of temperature condition
Under, 70min stirred with the revolving speed of 85r/min, obtain a kind of natural volcanic slurry facial mask compound preservative.
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