JP4587673B2 - Cleaning composition - Google Patents

Description

The present invention relates to a detergent composition not containing a preservative specified by the Pharmaceutical Affairs Law. More specifically, the present invention relates to a detergent composition using a specific fragrance and containing no preservative specified by the Pharmaceutical Affairs Law.

  In general, cleaning agents are often stored in warehouses or storefronts for a relatively long period of time from production to the start of use, and since they are used in small amounts after the start of use, the quality is long-term from the start of production to the end of use. It needs to be stable. Therefore, prevention of deterioration due to the decay of cosmetics is extremely important in order not to impair the commercial value.

  For this reason, various chemically synthesized preservatives have been used in conventional cosmetics for the purpose of preventing quality deterioration. Examples of such preservatives of chemically synthesized products include benzoic acid and its salt, isopropylmethylphenol, paraoxybenzoic acid ester (paraben), phenoxyethanol, sorbic acid and its salt, dehydroacetic acid and its salt, benzalkonium chloride, chloride Examples include alkyltrimethylammonium, chlorhexidine gluconate, and photosensitizer. Of these, paraoxybenzoic acid esters and phenoxyethanol are widely used as preservatives for cosmetics. (Non-Patent Document 1)

  In general, these chemically synthesized preservatives are not yet sufficient to prevent the generation of mold and yeast when the specified amount is added, and the addition amount is set so that the generation of mold and yeast can be sufficiently prevented. Increasing or using something that exhibits significant effects can cause skin irritation problems. In addition, since Escherichia coli, Pseudomonas aeruginosa, and the like that are easily grown in cosmetics are easily resistant to bacteria, they may be spoiled even when added in a prescribed amount.

  In addition, development of food preservatives and cosmetic preservatives containing natural products, particularly plant-derived extracts as active ingredients, is underway. For example, Arnica, Aloe, Fennel, Ages, Awaku, Auren, Hypericum, Camellia, Chamomile, Ginseng, Pepper, Salvia, Hawthorn, Salamander, Sicon, Perilla, Peonies, Birch, Honeysuckle, Horsetail, Prunus, Pepper , Tea, clove, touki, dokudami, garlic, hamamelis, loquat, hops, mukuroji, melissa, eucalyptus, lavender, lemon, rosemary and the like extracted with water or an organic solvent. (Patent Document 1)

  However, although the above plant extract is clear in terms of safety, it is effective only for certain specific fungi, and its antibacterial properties are relatively weak. No antiseptic effect is obtained. In addition, many plant extracts have unique odors, and exhibit a strong antiseptic effect by using two or more kinds of plant extracts together or using a combination of plant extracts and chemically synthesized preservatives. However, there is a problem that when blended into cosmetics, the commercial value is lowered due to its odor and the like, so that an amount showing effective antibacterial activity cannot be blended.

In addition, as a method to enhance the shelf life of cosmetics, a technology that makes antibacterial zeolite by exchanging antibacterial metal ions such as silver, copper, and zinc with zeolite, and uses this for hair cosmetics as an alternative to organic preservatives. Is known (Patent Document 2). In addition, the antibacterial zeolite is re-agglomerated and precipitated with essential components of fine-particle antibacterial zeolite, a polyhydric alcohol or saccharide having a valence of 2 or more, a mixture of both, an organic acid or a salt thereof, a mixture of both, and water. Antibacterial cosmetics that have been made difficult have also been proposed. (Patent Document 3)
However, although antibacterial zeolite is excellent in terms of antibacterial properties, when used as a preservative for cosmetics, there is a problem that skin irritation is strong and practicality is poor.

  Also, specific antibacterial phosphates containing antibacterial metal ions have been proposed as cosmetic preservatives. (Patent Document 4)

In addition, it is known that there are several kinds of fragrances that have strong antibacterial activity among many fragrances that make up the blended fragrances used to impart fragrances to products. It is known to be an active fragrance. (Non-Patent Document 2)
However, a perfume having a strong antibacterial activity has a very strong fragrance that is not suitable for cosmetics, and there is a problem that if an effective concentration that exhibits efficacy as a preservative is blended in cosmetics, it is odorless and does not become a product.

JP 2002-241217 A JP 60-174707 A JP 2000-7520 A JP-A-5-155733 Actual knowledge of cosmetics Toyo Keizai Shinposha published in 1987 Jon J.KABARA, perfume-based preservatives Essential oils and perfume substances as antibacterial agents, cosmetics / pharmaceuticals Antiseptic / disinfectant science (189-220), published by Fragrance Journal, 1990

  The problem to be solved by the present invention is that it does not use various chemically synthesized preservatives that may cause other problems such as skin irritation, but contains a fragrance having strong antibacterial activity as a preservative. Then, the odor is too strong, and it is difficult to obtain a cleaning composition that can be actually used.

  As a result of repeated investigations to solve the above problems, the present inventors combine natural essential oil with a special fragrance and cinnamic aldehyde, so that the fragrance becomes mild as a whole, and cinnamaldehyde is effective as a preservative. The present inventors have found that a detergent composition having a mellow fragrance can be obtained even when a certain concentration is used.

  The present invention is characterized in that it contains one or more essential oils selected from the group consisting of chamomile oil, dabana oil, galvanum oil, violet leaf oil and cinnamic aldehyde, and does not contain a preservative specified by the Pharmaceutical Affairs Law. In particular, the cleaning composition is characterized in that the content of the synamic aldehyde is 0.01 to 0.5%.

  The cleaning composition of the present invention comprises benzoic acid, benzoates, alkyldiaminoethylglycine hydrochloride, photosensitizer, chlorcresol, chlorobutanol, salicylic acid, salicylates, sorbic acid and salts thereof, dehydroacetic acid and salts thereof, trichlorohydroxy Diphenyl ether (also known as triclosan), p-hydroxybenzoate and its sodium salt, phenoxyethanol, phenol, sodium lauryldiaminoethylglycine, resorcin, zinc / ammonia / silver composite substituted zeolite, benzoic acid pantothenyl ethyl ether, isopropylmethylphenol, cetyl chloride Pyridinium, benzalkonium chloride, benzethonium chloride, chlorhexidine hydrochloride, orthophenylphenol, sodium orthophenylphenol, glucone Chlorhexidine, cresol, chloramine T, chlorxylenol, chlorphenesin, chlorhexidine, 1,3-dimethylol-5,5-dimethylhydantoin, alkylisoquinolinium bromide, thianthol, thymol, trichlorocarbanilide, parachlorophenol, Halocarban, hinokitiol, zinc pyrithione, methylchloroisothiazolinone / methylisothiazolinone solution, N, N-methylenebis [N- (3-hydroxymethyl-2,5-dioxo-4-imidazolidinyl) urea], para-iodide Even without the use of preservatives such as dimethylaminostyryl heptylmethylthiazolium listed in the Pharmaceutical Affairs Law (Heisei 13 Thick Labor 158, partially amended), there is an advantage that the quality is not deteriorated by bacteria, mold, yeast or the like.

  The chamomile oil used in the present invention is obtained by steam distillation of dried flowers of Matricaria chamomilla L. or Anthemis nobilis L .. Davana oil is obtained by steam distillation of the dried whole plant of Artemisia pallens. Galvanum oil is obtained by steam-distilling the exudates of Ferula galbaniflua and related plants. Violet leaf oil is obtained by re-extracting the concrete obtained by extracting fresh leaves of Viola odorate L. with petroleum ether with alcohol. The amount of these essential oils to be added to the cleaning composition is important, and 0.0001 to 3 times the amount of the synthetic aldehyde contained in the cleaning composition is suitable, and more preferably 0.001 to 0.001. 2.5 times the amount. If it is out of the above range, the scent of the cleaning composition is uncomfortable.

  The amount of the synthetic aldehyde contained in the cleaning composition of the present invention is 0.01 to 0.5%, more preferably 0.03 to 0.1% with respect to the cleaning composition. The proportion of the synthic aldehyde of the present invention is important, and if it falls outside the lower limit range, a sufficient antiseptic effect cannot be obtained, and if it exceeds the upper limit range, the scent of the cleaning composition becomes uncomfortable.

  In addition to the above-described essential components, the cleaning composition of the present invention has other components that are used in ordinary cosmetics within a range that does not impair the effects of the present invention, such as powder components, liquid fats, solid fats, waxes, Hydrocarbon, higher fatty acid, higher alcohol, ester, silicone, anionic surfactant, cationic surfactant, amphoteric surfactant, nonionic surfactant, moisturizer, water-soluble polymer, thickener, film agent, ultraviolet ray Absorbents, sequestering agents, sugars, amino acids, organic amines, polymer emulsions, pH adjusters, skin nutrients, vitamins, antioxidants, antioxidant aids, fragrances, water, etc. are added as necessary. Depending on the intended dosage form, it can be produced by a conventional method.

  EXAMPLES Hereinafter, the present invention will be described more specifically with reference to examples. However, the present invention is not limited to these examples.

[Formulation Example 1]
Fragrance 1 in which chamomile oil: cinnamic aldehyde was blended at a ratio of 70:30 was prepared.

[Formulation Example 2]
Fragrance 2 containing 70% of Davana oil: Cynamic aldehyde was prepared.

[Composition Example 3]
Fragrance 3 was prepared by blending galvanum oil: cinnamic aldehyde in a ratio of 70:30.

[Formulation Example 4]
The fragrance | flavor 4 which mix | blended violet leaf oil: cinnamic aldehyde in the ratio of 70:30 was created.

[Formulation Example 5]
Fragrance 5 was prepared by blending lavender oil: cinnamaldehyde in a ratio of 70:30.

[Composition Example 6]
Fragrance 6 was prepared by blending chamomile oil: thymol in a ratio of 70:30.

[Formulation Example 7]
Chamomile oil: A fragrance 7 was prepared by blending Yugenol in a ratio of 70:30.

[Test Example 1]
Growth inhibition tests against Bacillus subtilis, Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa were conducted using the blended fragrances of fragrance 1 to fragrance 7.

The microorganisms used in the test are as follows.
Scientific name Japanese name IFO number ATCC number
Bacillus subtilis Bacillus subtilis 3134 6633
Escherichia coli 3972 8739
Staphylococcus aureus Staphylococcus aureus 12732 6538P
Pseudomonas aeruginosa Pseudomonas aeruginosa 13275 9027

  The medium used was a solution obtained by dissolving 22 g of Meuler-Hinton Broth Medium “Becton Dickinson and Company” (hereinafter referred to as MH) in 1000 ml of purified water and autoclaving at 121 ° C. for 10 minutes.

  The sample was prepared by mixing and stirring the same amount of the blended fragrance and Tween 80 (polyoxyethylene (20) sorbitan monooleate), and then diluting to 0.5% (V / V) in a liquid medium. Create a double dilution column. Paraoxybenzoic acids were dissolved in dimethyl sulfoxide (hereinafter DMSO) and used in the same manner as a sample solution.

For the preparation of the bacterial solution, each bacterium was prepared to 1 × 10 ⁷ CFU / ml.

The culture test was performed by taking 100 μl of a sample and 5 μl of a bacterial solution on a microplate, stirring, sealing, and culturing at 37 ° C. for 16 to 18 hours to determine minimum inhibitory concentration (MIC).
The test results are shown in Table 1.

  From the results of Table 1, the fragrances 1 to 7 are usually used as preservatives for detergent compositions, and have the same growth inhibitory effect against Bacillus subtilis, Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa compared to parabens. You can see that

[Test Example 2]
A growth inhibition test for Candida and black mold was performed using the blended fragrances of fragrances 1 to 7.

The microorganisms used in the test are as follows Scientific name Japanese name IFO number ATCC number
Candida albicans Candida 1594 10231
Aspergillus niger black mold 9455 16404

  The medium used is RPMI-1640 Medium “SIGMA” (hereinafter RPMI-1640) 10.4 g and 3- [N-morpholino] propanesulfonic acid “SIGMA” (hereinafter MOPS) 34.53 g dissolved in purified water, 0.1 N. The pH was adjusted to 7 with NaOH to make the total volume 1000 ml, and then sterilized with a filter.

  The sample is prepared by mixing and stirring the same amount of the blended fragrance and Tween 80, and then diluting to 0.5% (V / V) in a liquid medium, and then creating a 2-fold dilution series. Paraoxybenzoic acids were dissolved in DMSO and used in the same manner as a sample solution.

As for the preparation of the bacterial solution, Candida was prepared at 2.5 × 10 ³ CFU / ml, and Black mold was prepared at 2.0 × 10 ⁴ CFU / ml.

  The test was carried out by taking 50 μl each of the specimen and the bacterial solution on a microplate, stirring, sealing, and culturing at 37 ° C. for 46-50 hours to determine the minimum inhibitory concentration. The results are shown in Table 2.

  From the results in Table 2, it can be seen that fragrances 1 to 7 show the same growth inhibitory effect against Candida and black mold compared to parabens, which are usually used as preservatives in detergent compositions.

[Formulation Example 8]
Shampoo base 1 was prepared according to the following prescription.
[Shampoo base 1]
Polyoxyethylene (2) sodium lauryl ether sulfate 9.0
Sodium lauryl sulfate 4.0
Palm oil fatty acid amidopropyl betaine 3.0
Highly polymerized methylpolysiloxane 2.0
Methyl polysiloxane 1.0
Palm oil fatty acid monoethanolamide 1.0
Propylene glycol 2.0
O- [2-hydroxy-3-trimethylammoniopropyl] hydroxyethylcellulose chloride 0.5
Ethylene glycol distearate 2.0
Purified water 75.3
Total 99.8

[Example 1]
Fragrance 1 was scented to 0.2% shampoo base 1 to obtain shampoo composition 1 of the present invention.

[Example 2]
Fragrance 2 was added to 0.2% shampoo base 1 to obtain shampoo composition 2 of the present invention.

Example 3
Fragrance 3 was scented to 0.2% shampoo base 1 to obtain shampoo composition 3 of the present invention.

Example 4
Fragrance 4 was added to 0.2% shampoo base 1 to obtain shampoo composition 4 of the present invention.

[Comparative Example 1]
Fragrance 5 was added to 0.2% shampoo base 1 to obtain shampoo composition 5.

[Comparative Example 2]
Fragrance 6 was aromatized to 0.2% shampoo base 1 to obtain shampoo composition 6.

[Comparative Example 3]
Fragrance 7 was added to 0.2% shampoo base 1 to obtain shampoo composition 7.

[Comparative Example 4]
Shampoo composition 8 was obtained by perfume 0.2% shampoo base 1 with methyl paraoxybenzoate.

[Test Example 3]
The shampoo compositions 1 to 4 of Examples 1 to 4 and the shampoo compositions 5 to 8 of Comparative Examples 1 to 4 were tested for antiseptic efficacy against mold and fungi.

  The test method is to take 29.7 g of the specimen into a 50 ml sample bottle, add 0.3 ml of the group 1 or 2 fungus / spore suspension, mix well, and then place in a 25 ° C. incubator. Bacterial inoculation 3 (G1 only), 7,14,21 (G2 only), 28 days later, 1g of each sample was serially diluted and prepared by a pour method. Bacteria were fungi at 30 ° C for 48 hours. Cultivated at 25 ° C for 3-7 days, count the number of growing colonies, and multiply this by the dilution factor to calculate the number of surviving bacteria per gram of specimen (CFU / g). The behavior of the number of bacteria for each specimen was determined.

Each strain used in the test is as follows.
Group 1: Staphylococcus aureus ATCC # 6538
Escherichia coli ATCC # 8739
Pseudomonas aeruginosa ATCC # 9027
Group 2: Candida albicans ATCC # 10231
Aspergillus niger ATCC # 16404
Penicillium sp.

  The test period is from July 26 to August 27, 2002.

The determination of efficacy was accepted when the following criteria were satisfied.
Group 1 bacteria (bacteria)
By the 28th day of inoculation, the number of surviving bacteria decreased to below the detection limit (<10 CFU / g / ml) Group 2 bacteria group (fungi)
Tables 3 and 4 show the results of reduction of the number of living bacteria to less than 0.1% of the number of inoculated fungi by the 28th day of inoculation.

  From the results of Table 3 and Table 4, the shampoo compositions 1 to 4 of the present invention are products that do not cause product deterioration due to molds and bacteria that are inferior to those of the shampoo composition 8 that contains paraben as a preservative. I understand that.

[Test Example 4]
The shampoo compositions 1 to 4 of Examples 1 to 4 and the shampoo compositions 5 to 7 of Comparative Examples 1 to 3 were functionally analyzed using the general panel (n = 9) by using the general panel (n = 9). Evaluation was performed.

The evaluation standard of fragrance is as follows.
3: A fragrance with no discomfort.
2: Fragrant fragrance without discomfort.
1: Unpleasant fragrance
0: Very uncomfortable and bad scent.
The results are shown in Table 5.

  From the results in Table 5, it can be seen that the shampoo compositions 1 to 4 of the present invention have a very fragrant fragrance without any discomfort.

Example 5
A body soap 1 of the present invention was prepared according to the following formulation.
[Body soap 1]
Polyoxyethylene (2) sodium lauryl ether sulfate 15.0
Lauryl sulfate triethanolamine 5.0
Palm oil fatty acid amidopropyl betaine 5.0
Ethylene glycol distearate 2.0
Glycerol monopalmitate 1.0
Adsorbed purified lanolin 2.0
Glycerin 2.0
Propylene glycol 3.0
Fragrance 1 0.2
Purified water 64.8
Total 100.0

Example 6
A face wash 1 of the present invention was prepared according to the following formulation.
[Face wash 1]
Stearic acid 10.0
Lauric acid 10.0
Stearyl alcohol 6.0
Hydrogenated lanolin 4.0
Squalane 9.0
Octyldodecanol 3.0
1,3-butylene glycol 6.0
Polyethylene glycol 1500 4.0
Polyoxyethylene (25) cetyl ether 3.0
Glycerol monostearate 2.0
Potassium hydroxide proper amount fragrance 2 0.1
Purified water balance <br/> Total 100.0

  According to the present invention, it is possible to provide a scented detergent composition that does not deteriorate in quality due to bacteria, fungi, yeast, and the like, without using various chemically synthesized preservatives such as benzoic acid and benzoates.

Claims (1)

1 type or 2 types or more essential oil chosen from the group which consists of dabana oil, galvanum oil, violet leaf oil, and cinnamic aldehyde, content of cinnamic aldehyde is 0.01-0.5%, said essential oil And the content ratio of cinnamic aldehyde is 70:30, and benzoic acid, benzoates, alkyldiaminoethylglycine hydrochloride, photosensitizer, chlorcresol, chlorobutanol, salicylic acid, salicylates, sorbic acid and salts thereof , Dehydroacetic acid and its salts, trichlorohydroxydiphenyl ether (also known as triclosan), paraoxybenzoic acid ester and its sodium salt, phenoxyethanol, phenol, sodium lauryldiaminoethylglycine, resorcin, zinc / ammonia / silver complex substituted type Olite, benzoic acid pantothenyl ethyl ether, isopropylmethylphenol, cetylpyridinium chloride, benzalkonium chloride, benzethonium chloride, chlorhexidine hydrochloride, orthophenylphenol, sodium orthophenylphenol, chlorhexidine gluconate, cresol, chloramine T, chloroxylenol, chloro Phenesin, chlorhexidine, 1,3-dimethylol-5,5-dimethylhydantoin, alkylisoquinolinium bromide, thianthol, thymol, trichlorocarbanilide, parachlorophenol, halocarban, hinokitiol, zinc pyrithione, methylchloroisothi Azolinone / methylisothiazolinone solution, N, N-methylenebis [N- (3-hydroxymethyl-2,5-dioxo-4-imida Zoridinyl) urea], a detergent composition characterized by not containing paradimethylaminostyryl heptylmethylthiazolium iodide .